Subject Index

Abetalipoproteinemia II 711 Abscesses I 282 Acatalasia 1163 Accelerated globulin deficiency I 407 Acetaldehyde II 644 Acetamide, Drug induced hemolytic ane-

mia 1170 Acetonuria in galactosemia I 167 Acetylaminofluorene metabolism II 980 Acetyl-CoA carboxylase I 60 Acetoacetyl-CoA I 54 Acetyl-CoA I 54 Acetyl-CoA carboxylase I 278 Acetyl-CoA-ACP transacylase I 62 Acetylcholine I 260 Acetylcholine receptors I 528 Acid base I 570

Acetic acid I 570 Hydronium ion, I 571 Muriatic acid I 570, 571 Natron 1570 Potash 1570 Sulfuric acid I 570

Acid phosphatase II 937 - Gaucher's disease 1193 Acidosis I 574

Albright's disease I 575 Lung 1576 Metabolic I 574 Proximal tubular I 576 Tubular 1575

Aconitase I 29 - Mechanism of action I 30 Acrodermatitis enteropathica 1252 2-Acroleyl-3-amino-fumarate I 272 Acromegaly I 426

Diabetes 1431 Glucose tolerance 1431 Gonadal function I 431 Eosinophilic adenoma I 429 Lactogenic effect I 431 Osteoporosis I 432

ACTH 1530 Corticotropin-releasing factor (CRF) 1475 Covalent structure 1472 Humoral feedback 1475 Metabolic effect I 476 - Adenosine cyclic phosphate 1476

Adenyl cyclase I 476 Corticosteroidgenesis I 476 Cyclic adenylate I 476 Lipogenesis 1476 Urea formation 1476

Properties I 471 Release 1475 - Adrenal weight, effect of hypophy­sis 1475 Secretion control, median eminence 1475

- Releasing hormones I 474 - Hypothalamic nuclei 1474 - Portal system of the hypophysis 1473

Actinomycin D II 615 Active carcinogens II 982 Adenine I 210 Adenosine triphosphatase, nucleus

183 Adenyl cyclase I 455, 529, 530 5'-Adenylic phosphatase, nucleus

183 Addison's disease I 565, 559

Azotemia I 565 Electrolyte I 565 Hyperpigmentation 1565, 566 Hypertension I 565 Ketosteroids I 566

Adiposogenital dystrophy I 433 Adrenal adenoma, virilizing I 494 Adrenal carcinoma I 494 Adrenal cortex I 458

Anatomy I 458 Embryonic development 1459 Fascicularis I 459 Glomerulosa I 459 Histophysiology I 459 - x-zone I 460 Reticularis I 459 Spongiocytes I 459 Sympathogonia I 459

Adrenal deficiency I 277 Adrenals I 282 Adrenocortical hormones I 460 - Glucocorticoid I 460 - Mineralocorticoid I 460 Adrenogenital syndrome I 493 - Hyperpigmentation I 493 - Hypertension I 493 - Virilism I 493 Afibrinogenemia I 420 Aflatoxin II 983, 994 Agammaglobulinemia 1159 Aging, cholesteryl esters in arteriosclerosis

II 683 Alanine RNA 1110 Alanine tRNA base sequence I 111 Albers-Schonberg disease 1358 Albinism I 178

Melanin I 178 - Melanocyte I 178 - Tyrosinase I 178 Albumin I 158 Alcohol I 208 - (X-aminolevulinic dehydrase II 650 - Congeners II 642 Alcohol and diet II 643 Alcohol and drugs II 650 Alcohol dehydrogenase 1311, II 642 Alcohol metabolism II 642, 646 - Acetaldehyde II 642, 644

Catalase II 643 Fatty acid shuttle II 644 Fatty acid synthesis II 646 (X-glycerophosphate shuttle II 644 Malate aspartate II 644 Malate citrate shuttle II 644 Mitochondria II 642, 646 Mixed function oxidase II 643 NADHjNAD ratios II 644 Neurological adaptation II 643 Smooth endoplasmic reticulum II 647 Transhydrogenase II 644 Triglyceride oxidation II 646

Alcoholism I 266, 382 Bronchiectasis II 648 Deteriora tion II 650 Fatty cyst II 647 Intoxication II 650 Mallory bodies II 647 Myocardial disease II 649 Myopathy II 649 Pulmonary emphysema II 648 Pulmonary fibrosis II 648 Vitamin Bl I 266

Aldolase, nucleus I 80 Aldosterone I 554

ACTH 1557 Addison's disease I 559 Atrial receptors I 556 Blood volume I 555 Cardiac failure I 555 Cirrhosis I 555 Glomerulosa cells I 554 Mode of action I 559 Potassium I 555 Receptor I 560 Secretion I 555 Stretch receptor I 556

Aldosteronism I 562 Baroreceptors I 563 Blood volume I 564 Hypematremia I 563 Hypertension I 562, 564 Hypokalemia I 563, 564 Osmoreceptors I 563 Primary I 562 Secondary I 563

Aleutian mink disease II 1009 Alkaline phosphatase 1340; II 937 Alkalosis I 581 - Metabolic I 574 - Respiratory I 582 Alkaptonuria I 177 - Articular cartilages I 178 Allergic encephalitis II 668 Allergic granulomatous, angiitis II 879 Alloisoleucine in maple syrup disease

I 181 Allopurinol I 224 Alloxan I 211 - Diabetes I 514

II

Alloxan, Diabetic rats I 513 Alloxantin I 211 Alpha-Amanitin I 120 Alzheimer cells I 160 Alzheimer's disease II 662 ~ Neurofibril densification II 662 a-Amanitine II 615 Amino acid I 149, 587

Concentration in muscle I 283 Decarboxylation I 300 Excretion I 546 Ketogenic I 589 Metabolism ~ Ammonium acetate administration II 1034 ~ Fluoroacetate administration II 1034

In hypoglycemia II 1034 Liver 1585 Mitochondrial infarct II 1034 Transport I 585 ~ Cystinuria I 585 ~ Hartnup disease I 585 ~ Pyridoxal phosphate I 585

Amino acid acetylation I 587 ~ Phenylacetylglutamine I 588 Amino acid activation I 107 Amino acid code I 115

Amber mutation I 118 Nonsense codon I 118 Ocre mutation I 118 Punctuation codons I 118 Termination co dons I 118 Tobacco mosaic virus I 107 Tryptophan synthetase I 118

D-Amino acid oxidase 136 L-Amino acid oxidase I 36 Amino acyl RNA synthetase I 108 b-amino levulinic acid I 203 b-amino levulinic acid dehydrase I 203 b-amino levulinic acid synthetase I 203, . 208 ~ Porphyria I 209 Aminopterin I 227 D-amino oxidation I 301 Aminoaciduria in galactosemia I 167 Aminopeptidase II 937 a-aminolevulinic dehydrase II 650 6-aminopurine 1210 Ammonia I 573 ~ Glutaminase I 573 ~ Glutamine I 573 ~ Secretion I 573 Amiphipatic protein II 1078 Amniocentesis 1241 Amylases 1503 ~ Calcium I 503 Amyloid fibrils II 660 Amyloidosis II 655

Diabetes II 659 Experimental II 659

Amyloid fibrils II 659 Bacteria II 658, 659 Casein diet II 659 Chondroitin sulfate 11659 y-globulin II 659

Heart II 656 Hodgkin's disease 11659 Immunoblasts 11660 Kidney II 656, 657 Leprosy II 659 Liver II 656, 658 Myxedema II 659 Pathogenesis II 658 ~ Plasmocytosis II 659 Pathological anatomy II 655

Primary 11655 Secondary II 655 Spleen II 656 TB II 659

Amyotrophic lateral sclerosis II 672 Amy tal I 50, 52 Anaphase I 87 Anaphylaxis 11834 Anderson's disease, see Glycogen storage

disease I 166 Anemia 1264 ~ Hemolytic I 391 ~ Thalassemia I 157 Anephrotensin 1478 Anesthetics I 550 Angina pectoris II 697, 705 Angiotensin, Dipeptidyl carboxypeptidase

1558 Angiotensin II

Arterioles I 558 Blood pressure I 559 Cyclic AMP I 599 Epinephrine I 558 Zona glomerulosa I 558

Angiotensinogen I 557 Aniline derivatives 11983 ~ Naphthylamine II 984 ~ 2-Naphthylhydroxylamine 11984 Antemortem 1417 Anterior poliomyelitis 11672 Antibodies II 805

Age 11816 Antigen-binding sites II 807 Blood levels II 816 Constant segment II 807 C region 11819 Cytotoxic II 833 ~ Membrane II 833 Cytotropic II 832

Bradykinin II 833 Cyclic AMP II 833 Degranulation II 833 Eosinophilia II 833 Histamine II 833 Pausnitz-Kustner reaction II 832 Reagin II 832 Serotonin II 833

Domains II 807 Fa fraction II 807 Fc fraction II 807 Fa fragment II 805 Fc fragment II 805 Gamma globulins II 805 Heavy chain II 806 Heredity II 816 Host II 816 IgA II 805 IgD II 805 IgE II 805 IgG II 805 IgM II 805 y-chain II 806

~ j-chain II 819 K chain II 806 K type II 806 L type 11806 Light chain II 806 Molecular structure II 807 Synthesis II 817 ~ Somatic mutation II 817 ~ Template theory II 817 Variable segment II 807 V region 11819

Antigens II 805, 808 Administration II 817

~ Antibody reaction II 812

~ Agglutinins 11812 ~ Hemolysins 11812 ~ Precipitins II 812 Determinants 11808

Subject Index

~ Conformational II 809 ~ Sequential II 809 Haptenes II 808

Anoxia 1542 Antimycin I 43 Antimycin A 140 a,-Antitrypsin deficiency 11633 ~ Chronic obstructive lung disease II 633 ~ Cirrhosis of the liver II 633 Apatite crystals I 336 Apoferritin synthesis I 364 Apoproteins II 688

ApoA-II 11688 ApoB II 688 ApoC II 688 ApoC-I 11688 ApoC-III 11688 Apo HCL II 688 Chylomicrons II 689

Apotranscarboxylase I 280 Arachidonic acid II 639 Arginase, nucleus I 84 Arth us reaction II 836 ~ Pathology II 836 ~ Systemic II 836 Aromatic amino acids I 173 ~ Intermediary metabolism I 173 ~ ~ Pathology I 173 Arteries II 679

Biochemistry II 679 ~ Enzymes II 680 ~ Glucose-6-phosphate dehydroge­nase II 680 ~ Glyolysis II 680 ~ Hydrolases II 680 ~ Polysaccharide II 680 Caveolae 11679 Desmosomes II 679 Endothelium II 679 Lathyrism II 679 Media II 679 Morphology II 679 Regeneration II 680 ~ Copper deficiency II 681 ~ Freezing II 681 ~ Thrombi II 681

Arteriosclerosis I 369 Blood lipids 11701 ~ HDL II 701 ~ a-lipoprotein II 701 Cholesterol levels II 697 Cortisone II 699 Cushing's syndrome II 699 Diet II 697 Disease II 697 Epidemiology II 697 Estrogen II 698 Experimental II 700 ~ Irradiation II 701 Fatty acid essential 11697 Hemodynamic factors II 702 Heredity II 697 Hormones II 697 Hypothyroidism 11698 Insulin II 699 Myocardial infarct II 701 Nicotinic acid II 698 Origin of lipids II 702 Pathogenesis II 697, 709 Pyridoxine deficiency II 698 Triac II 699

Articular cartilages in alkaptonuria I 178

Subject Index

Astrocytes II 663 Aschoff body II 869 Ascobic acid I 24, 25, 281 ~ in Phenylketonuria I 174, 175 Aspartic acid oxidase I 36 Astrocyte II 663

Blood-brain barrier II 663 Clasmatodendrosis II 663 Dendrophagia II 663 Fibrous II 663 Protoplasmic II 663 Sucker feet II 663

Astrocytosis II 663 Astro gliosis II 663 Atherosclerosis I 303, 326; II 679

Angina pectoris II 705 Brain infarct II 708 Cerebral hemorrhage II 708 Consequences II 705 Coronary occlusion II 705 Diabetes II 700 Edema II 681 Electrocardiographic findings II 707 Elemen tary lesions II 681 Embolism II 707 Encephalomalacia II 708 Endothelial injuries II 682 Esterification of cholesterol II 704 Fat metabolism II 685 Fibrosis II 683 ~ Copper deficiency II 683 H~modialysis II 700 Lipid accumulation II 683

Free cholesterol II 683 Cholesteryl esters II 683 Cholesteryl oleate II 683 Lecithin II 683 Sphingomyelin II 683

Myocardial infarct II 705 Myxedema II 700 Nephrosis II 700 Polyol metabolism II 682 Smooth muscle proliferation II 683 Smoking II 700 Sphingomyelin II 705 Stress II 700 Thrombosis II 684 Thrombus II 707

ATP-ADP exchange reaction 152 ATP lyase 161 ATP_ 32p; exchange 152 A TPase release I 52 Atrial receptor I 556 Autoimmune disease II 870

Acquired hemophilia II 870 Allergic granulomatous angiitis II 879 Fibrinoid necrosis II 879 Hemolytic anemia II 870 Hypersensitivity angiitis II 879 Immunological neutropenia II 870 Immunological thrombocytic purpura II 870 Immunologic vasculitis II 878 Lupus erythematosus II 871 Polyarteritis nodosa II 878 Polymyositis II 881 Rheumatoid arthritis II 875 Sarcoidosis II 880 Scleroderma II 881 Thyroiditis II 870 ~ Hashimoto's disease II 870 Wegener's granulomatosis II 879

Autoimmune thyroiditis, Askanazy cells II 870

Autoimmunity II 671 Autolysis 1610

Avian leukosis viruses II 1010 ~ Lymphomatosis II 1010 ~ Rous sarcoma II lOll Avidin 1278 Azaserine, purine metabolism 1214 Axon II 664 ~ Degeneration II 668 Axoplasm II 664 Azauracil I 226 Azide 152 Azo derivatives II 977

Amination II 977 Aminoazotoluene II 977 Amino-4-azobenzene II 977 Changes in liver cells II 979 ~ Basophilia II 979 ~ Hyaline bodies II 979 ~ Mitochondria II 979 Demethylation II 978 Halogenation II 977 Hydroxylation II 977 Methylation II 977 Protein binding II 978 ~ H2 5S protein II 978

Azobenzene II 977 Azonaphthalene II 977

a-a-azonaphthalene II 977 ~ p-p-azonaphthalene II 977

B cells II 824 ~ Antigen recognition II 825 ~ Receptors II 825 Bacterial transformation 194 Bacteriophage I 96; II 997 ~ Fate 196 Bacteriostatic agents II 788

Cationic proteins II 788 H 20 2 , II 788 Lactic acid II 788 Myeloperoxidase II 788 Phagocytin II 788

Balanced Polymorphism I 149 ~ Drug induced hemolytic anemia I 170 Barbi tura tes I 24 Basal cell carcinoma II 1100 Basement membranes II 861, 930 Behinic acid 1195 Benamid I 224 Bence Jones proteins II 806 Benzoquinoacetic acid and methemoglobi-

nemia I 157 Beriberi II 266, 268

Adenosine-Y-phosphatase 1270 Cerebellar ataxis I 270 Clinicopathological aspects I 267 Demyelination I 267 Edema 1266 Hyperoxaluria I 270 a-ketoglutarate decarboxylase 1270 Lactic acid I 268 Oxythiamine I 267 Pa tho genesis I 268 Polyneuritis I 266 Pyrithiamine I 267 Pyruvemia I 269 Pyruvic acid I 268, 269 Pyruvic decarboxylase I 269, 270 Thiaminase I 267 Transketolase I 270 Vitamin BI 1266

Bicarbonate absorption I 573 Biguanides I 508 Bilirubin I 385

Glucuronide I 387 ~ Glucuronyl transferase I 387

III

Direct van den Bergh reaction I 387 Excretion I 387 Hemolytic jaundice I 387 Indirect van den Bergh reaction 1387 Metabolism I 388 Transport I 385 UDP-glucuronic acid I 387

Biocytin I 279 Biotin 131

Acetyl CoA carboxylase I 278 Biocytin I 279 Biotinidase I 279 Deficiency I 278 ~ Avidin I 278 ~ Methylmalonyl 1278 Mitochondria I 278 Propionyl CoA 1278 ~ Carboxylase I 278

Biotinidase I 279 Bile acids I 596; II 685

Cholestasis I 596 Cholecystolithiasis I 596 Cholic acid formation I 596 Conjugation, Glycine I 597 ~ Taurine I 597 Disease I 597 Intestinal bypass I 599 Metabolism I 598 Primary I 596 Secondary I 596

Bile duct I 599 ~ Cholecystokinin I 599 ~ Cystic duct I 599 Bile pigment I 385

Bilirubin I 385 ~ Hemoglobin breakdown I 385 ~ Metabolism I 385 ~ Protoporphyrin breakdown I 386 Bittner virus II 1012, 1017 Bladder cancer II 1100 Blocking antibodies II 1103 Blocking antigens II 1103 Blood brain barrier I 389 Blood coagulation I 396

Antihemophilic globulin I 399 Autoprothrombin I-C 1401 Autoprothrombin III 1401 Factor V 1401 Factor VII I 400 Factor X 1401 Factor XIII deficiency I 408 Fibrin 1399, 405 Fibrinogen I 399, 404 Fibrinolysis I 413 Fibrinopenia I 408 Hageman factor I 400 ~ Deficiency I 408 Idiopathic thrombocytopenia 1412 Inactive plasma, thromboplastin compo­nent 1401 Plasma-accelerating globulin I 399 Plasma AC globulin I 399 Platelets I 409 ~ Viscous metamorphosis 1401 Prothrombin 1401 ~ Deficiencies I 408 Prothromboplastin I 399 Stuart-Prower factor 1400 Symptomatic thrombocytopenia pur­pura 1412 Theory 1399 Thrombin 1399, 401, 402 Thrombocytopenic purpura, neonatal 1413 Thromboplastin I 399, 400

IV

Blood coagulation, Thromboplastin an teceden t I 400 Thromboplastin component deficiency 1408 Thromboplastin extrinsic formation 1400 Thromboplastin intrinsic formation 1400 Tissue factors I 400 Vascular factors 1413 Vitamin K I 399 - Deficiency I 409

Blood groups II 840 A group II 841 ABO system II 841 B group II 841 Cancer II 842 Coombs' reaction II 841 Globosides II 842 H gene II 842 Incompatibility, newborn II 843 o group II 841 Rh group II 841 Rh system II 843 Transfusion II 842 Trophoblast II 842

Blood leukocyte, purine metabolism 1216 Blood lipids II 689 Blood pH I 574

Acidosis I 574 - Alkalosis 1574 - Respiration I 574 Blood platelets, viscous metamorphosis

1401 Blood pressure I 543, 559 Blood volume I 555, 557 Bloom syndrome II 732 Body fluids I 539

Donnan equilibrium I 539 - Electrolytes I 539 - Extracellular I 539 - Intracellular I 539 Bone atrophy I 351 Bone growth I 307 Bone marrow hyperplasia and thalassemia

I 157 Bone marrow, purine metabolism I 216 Bone metabolism I 334 Bone resorption I 352 Bouyant density I 66 Bradykinin 1319; II 771, 833 - Amino acid sequence II 772 - Bradykininogen II 773 - Shock II 773 Bragg's equation I 337 Brain 1514 - Tay-Sachs disease I 186, 187, 188 Branched amino acids in maple syrup dis-

ease I 181 Breast cancer 111012, 1016, 1100

Cystic hyperplasia II 961 Dialyzable inhibitor II 1012 Estrogens II 959, 961 Menopause II 961 Methylcholanthrene II 960 Nursing II 961 Precancerous lesions II 961 Prolactin II 960 Thyroid function II 961 Tumor inducing factors II 1012 Tumor inhibiting factors II 1012

Bregen-Moloney virus II 1012 Bronchiectasis II 648 Burkitt's lymphoma II 1100 Burkitt's sarcoma II 1025 Butyryl dehydrogenase I 55

Caffeine 1210 Calcitonin I 356, 562

Albers-Schonberg disease I 358 Amino acid sequence 1356 C cells I 357 Calcium, intestinal absorption I 358 Calcium, resorption I 358 Hypocalcemia 1357 Osteoporosis 1358 Receptors I 358 Thyroid carcinoma I 358 Thyrocalcitonin 1356

Calcium I 333 Excretion I 334 Hormone action I 532 Intestinal absorption I 343 Mitochondria I 532 Resorption I 358 Serum 1333 Sources I 333 - Food 1333 - Milk 1333

Calcium absorption I, 333 358 - Bile salt I 333 - Carrier protein I 333 Calcium metabolism, skeleton I 333 Cancer II 937

Adrenals II 964 - ACTH 11964 - Gonadotropins II 964 Ascites II 953 Bladder II 996 - Schistosomiasis II 996 Blood group II 842 Breast II, 949, 953, 961, 1025 Carcinogenesis, Human, Kidney II 994 Carcinoma in situ II 952 Cervix II 962

Among Jewish II 962 Among poor II 962 Among virgins II 962 Coitus II, 962 Estrogen II 962 Herpes virus II 962 Pregnancy II 962 Smegma II 962

Chromosomes II 957 - Heteroploidy II 957-959 - Philadelphia chromosome II 957 - Stem line II 959 Colon II, 950, 951, 1096 Differentiation II 954, 955 DNA contents 194; II 1039 DNA methylation II 1040 DNA physical difference II 1040 DNA synthesis 111040 Drugs 11994 Glycolysis I 9 - Lipomas II 1029 - Pasteur effect II 1029 Growth rate II 1038 - Chemotherapy II 1038 Heredity II 955

Animals II 955 Breast cancer II 956 Leukemias II 956 Lung cancer II 955, 956 Lymphosarcoma II 956 Mammary cancer II 955

Chromosomes II 957 Humans II 956

Breast cancer II 956 - Identical twins II 957 - Medullary thyroid carcinoma

II 957 - - Multiple exostosis II 957

II 957

Subject Index

Multiple polyposis II 957 Neurofibromatosis II 957 Nevoid basal cell carcinoma

- Retinoblastoma II 957 - - Xerodermapigmentosum II 957 - Polyendocrine adenomatosis II 957 High malignancy II, 1082 Hormones II 959

Adrenal II 964 Androgen II 970 Autonomous II 968 Biochemistry II 967 Bladder II 966 Blood levels II 969 Breast cancer II 959 Cervix II 962 Dependent 11968 Hypophysis II 964 17-Ketosteroids II 969 Kidney II 966 Liver II 966 Lymphatic tissue II 966 Ovary II 963 Prostate II 965 Skin II 966 Steroid levels II 969 Subcutaneous tissue II 966 Testicles II 966 Transplacental II 967 Urinary estrogens II 969 Uterus II 962

Host II, 1088 - Stroma II 1089 - Toxohormone II 1089 Host reactions II 1088 Host relationship II 1096

Anemia II 1097 Angiogenesis II 1098 Ectopic hormones II 1096

Bronchial carcinomas II 1097 Cancer pancreas II 1096 Carcinoid II 1096 Colon II 1096 Cushing's syndrome II 1096 Diabetes II 1096 Diabetes insipidis II 1096 Glucose tolerance test II 1096 Gonadotropin elaboration

II 1096 Hepatomegaly II 1097 Hypercalcemia II 1096 Hypoglycemia II 1096 Mammary glands 111096 Oat cell carcinoma II 1096 Ovary II 1096 Parathyroid II, 1096 Pheochromocytomas II 1096 Prostate II 1096 Sympatheticoblastomas II 1096 Thymus II 1096 Thyroid hormone II 1096 TSH secretion II 1096

Hyperuricemia II 1098 Immunity II 1098 Kidney enlargement II 1097 Neural degeneration 111097 Nutrition II 1097 - Cachexia II 1097 - Negative nitrogen balance

II 1097 - - Negative phosphorus balance II 1097 - - Nitrogen II 1097 - Uric acid accumulation 111097 Hypophysis II 964

Subject Index

Adrenocorticotropic II 964 Autonomous II 965 Dependent II 965 Mammotropic II 964 Thyrotropic II 964

Invasion II 951, 1088 Cancer en cuirasse II 952

- Cytotoxic substances II 1088 - Hydrolytic enzymes II 1088 - Pressure II 1088 Isozymes II 1086 - Carbamyl phosphate synthetase II 1087 - Serine dehydrase II 1097 Kidney II 994 Liver II 994, 996 - Aflatoxin II 994 - Schistosomiasis II 996 Lung II 1096 Lymph nodes II 952 Metabolic regulation II 1041 - Glycolysis II 1042 Metabolism

Amino acids II 1034 Asparaginase II 1035 A TP utilization II 1036 Azaserine II 1035 Hodgkin's disease II 1034 Leukemia II 1034 Oxygen utilization II 1036 Yoshida sarcoma II 1034

ATPase II 1033 Carrier System II 1030 Cytochrome c II 1032 Electron transport II 1034 Electron transport chain II 1031 Glycolysis II 1028, 1030 - Hepatomas II 1029 - High aerobic II 1028 - Pasteur effect II 1028 Hepatomas II 1031, 1034 Hexose monophosphate shunt

II 1030, 1031 Krebs cycle II 1030 Levels of NAD II 1033 Mitochondria II 1033 Mitochondrial DNA II 1032 Mitochondrial number II 1033 Mitochondrial permeability II 1033 NADase II 1033

- Nucleic acid, DNA synthesis, ex­ploitable differences II 1037

Nucleic acid synthesis II 1036 - - de novo pathway II 1037 - - Salvage pathway II 1037 - Oxidative phosphorylation II 1032, 1033 - - ATP catabolism II 1032 - - Number of mitochondria II 1032

Oxygen consumption II 1032 - Oxygen uptake II 1030 - Respiration II 1032 - Sugar transport II 1030 Metastasis II 951,952, 1088, 1089

Adhesiveness II 1090 Blood vessels II 1090 Cell adhesion II 1094 Cell membrane II 1093 Contact inhibition II 1094 Lymphatic invasion II 1090 Macrophages II 1095 Retrograde progression II 1092 Stroma II 1090,1091

Minimal deviation hepatomas II 1082 Ovary II 954, 963, 1096

- Carcinogen II 963 - Implantation in spleen II 963 - X-irradiation II 963 Pancreas II 1096 Prostate II 965, 1096

Castration II 965 Chinese II 965 Estrogen II 965 Japanese II 965 Testosterone II 965

Radiation II 742 RNA, Walker tumor II 1041 RNA base composition II 1041 RNA metabolism II 1040 - RNA release II 1041 Schistosomiasis II 996 Stomach II 994 Skin, squamous cells cells carcinoma II 955 Teratomas II 954 Testicles II 966

Androgen II 966 Cryptorchidism II 966 Estrogen II 966 Progesterone II 966 Zinc chloride II 966

Thyroid II 1096 Toxohormones 11953 Transplacental II 967 - Vagina II 967 Uterus II 962

Endometrial hyperplasia II 962 Estrogen II 962 Estrus II 962 Pregnancy II 962 Progesterone II 962

Vagina II 967 Virus II 996

Antigenic properties II 1017 Bittner virus II 1017

- Cross-immunity II 1017 - Shope papilloma II 1017 Biochemistry II 10 18 - Polyoma virus II 1018 - Rauscher leukemia virus II 1019 - Rous sarcoma II 1918 Bi ttner virus II 10 12 Breast carcinoma II 1025 Burkitt's sarcoma II 1025 Cervical cancer II 1026 Characteristics II 1014

Morphology II 1014 Size II 1014 Type A II 1014 Type B II 1014 Type C II 1014

Epstein-Barr virus II 1026 Herpes-like agent II 1025 Herpes virus II 1025 Hodgkin's disease II 1013, 1025 Hypothesis II 1027 Infectious myxomatosis II 996 In humans II 1024 Leukemia II 10 12, 1025 Liposarcomas II 1026 Lucke's disease II 1026 Melanomas II 1026 Modulating factors II 1015

Age II 1016 Carcinogens II 1015, 1016 Helper virus II 10 15 Heredity II lOIS Host II 1015 Tissue susceptibility II lOIS X-irradiation II 1016

Oncogenic gene theory II 1027

Papilloma II 1012, 1026 Parotid tumors II 1013 Proto virus theory II 1027 Rous sarcoma II 996 Shope papilloma virus II 1011 Transformation II 1023 Type D II 1014 Viral replication II 1019 X-irradiation II 1041

Cancer Cells, Electrophoretic mobility II 1095

Calcium II 1095

V

Fibroblast transformation II 1095 Metastasis II 1095 Neuraminidase II 1095 Ribonuclease II 1095 Sialic acid II 1096

Gene expression II 1065 Cancer immunity II 1098

Antigen loss II 110 I Antigens II 1100

Cell surface proteins II 110 I - Chemistry II 1101 - Intracellular II 1101 - Membranes II 1101 Basal cell carcinoma II 11 00 BCG II 1099 Blocking antibodies II 1103 Burkitt's lymphoma II 1100 Cancer in smokers II 1103 Cancer in young people II 1103 Carcinoembryonic antigens II 1101, 1102 Carcinoma of bladder II 1100 Carcinoma of breast II 1100 Carcinoma of colon II 1100 Carcinoma of esophagus II 1100 Carcinoma of lung II 1099, 1100 Carcinoma of pancreas II 1100 Carcinoma of parathyroid II 1100 Carcinoma of stomach II 1100 Carcinoma of thyroid II 1100 Carcinoma of urinary tract II 1099 Chemical carcinogens II 1100, 1102 Circulating antigens II 1103 Circulating lymphocytes II 1103 Colony inhibition test II 11 02 iX-fetoprotein II 11 0 I iX,-fetoprotein II 1101 Hepatomas II 1100 Hodgkin's disease II 1099 Hypernephroma II 1100 Immune RNA II 1099 Immunological enhancement II 1102 Immunosuppression II 1102 Immunosurveillance II 1103 In animals II 1100 - Antigens II 1100 - Tumor specific antigens II 1100 - Viral antigens II 1100 In spontaneous tumors II 1104 Irradiation II 1099 Leukemia II 1099, 1100 Liposarcoma II 1100 Melanoma II 1100 Neuroblastoma II 1100 Osteogenic sarcoma II 1100 Retinoblastoma II 1100 Squamous cell carcinoma II 1100 Transfer factors II 1099 Wilm's tumor II 1100

CAP factor I 119 Carbamyl aspartic acid synthetase

1226 Carbamyl phosphate I 226 Carbamyl phosphate synthetase II 1087

VI

Carbohydrate metabolism I 163 ~ Inborn errors I 163 ~ ~ Glycogen storage disease I 163 Carbohydrates, sparing effect on proteins

1589 Carbon tetrachloride intoxication II 637

ATPase II 640 A TP level II 638 Chloroform II 639 Conjugated-dienes II 639 Endoplasmic reticulum II 638 Fatty acid II 639 Free radicals II 639, 640 Glucose-6-phosphatase II 640 Heterolytic fission II 639 Homolytic cleavage II 639 Lysosomes II 638 Malonyl dialdehyde II 640 Mitochondria II 638

Mixed function oxidase II 640 Peroxidation II 640

~ Solvent theory II 638 ~ Toxic metabolites II 638 Carbonic anhydrase I 554 Carbonic hydrase I 377 ~ Zinc 1377 Carboxypeptidase I 256 ~ Procarboxypeptidase I 259 ~ Zinc 1259 Carcinogens II 970

Afla toxin II 983 Aniline derivatives II 983 Azo derivatives II 977 Cycasin II 983 1,2,5,6-dibenanthracene II 970 Electronic structure II 972 Fluorene derivatives II 979 K region II 972 L region II 972 Mixed-function oxidase II 975 Polycyclic hydrocarbons II 970

3,4,-benzene pyrene 11971 Cholanthrene II 971 1,2,5,6-dibenzanthracene 11970 1,2,7,8-dibenzanthracene II 970

Epoxide II 973 Epoxide hydrase II 976 Hydrogenation II 971 K region epoxide II 973, 974 Methylation II 971 9,10-methyldibenzanthracene 11971 Polymers II 984 ~ Free radicals II 985 Protein binding II 972 Tar II 970 Urethane II 984

Carcinogenesis II 970 Chemical II 970

DNA repair II 990 Humans II 991

Aniline II 992 Asbestos II 992 Chrome II 995 Contraceptives II 992 Creosote II 995 Dyes II 994 Insecticides II 992 Isoniazid II 995 Liver II 994 Marijuana II 993 Nickel II 995 Penicillin G II 994 Petroleum products II 994 Pionolactone II 994 Propylactone II 994 Reserpine II 995

Smoking II 993 Stomach II 995 Talc II 992 Vinyl chloride II 992

Lung cancer II 993 Mechanism II 985 ~ Activation scheme of AAF

II 986 ~ ~ Metabolism of dimethylamino­azobenzene II 986

Silicates II 992 Transformation II 988 ~ Cyclic AMP II 989 ~ Cyclic GMP II 989 Transformation in vitro II 988

Cyclic GMP II 988 Drugs, ~ Prospective approach II 995 ~ Retrospective approach II 995 Mechanism, ~ Activation II 986 ~ N-hydroxy derivatives II 985 Mutation II 990 Two-stage II 986

Croton oil II 987 Cyclic AMP II 988 Initiator II 987 Methylcholanthrene II 987 Promotors II 987

12-0-tetradecanoylphorbol-13-acetate II 987 Viral II 10 10 ~ Avian Leukosis viruses II 10 10

Carcinoembryonic antigen II 1101 Carcinoids II 1096 ~ In phenylketonuria I 174 Cardiac failure I 555 ~ Angiotensin II I 584 ~ Renin 1584 ~ Salt and water retention I 583 Cardiac Hypertrophy 11919

Cell membrane II 920 DNA synthesis II 920 Glucose uptake II 920 Glucose utilization II 920 Mitochondria II 920 Nuclear pores II 920 Nucleotide pools II 920 Polyploidy II 920 Shunt pathway II 920

Carrier mechanism II 1077 Catalase 141,272; II 643 Ca taracts I 284, 354 Cell adhesion II 1094 ~ Calcium II 1094 ~ Hepatoma II 1094 Cell communication II 1094 Cell hybridization II 1061 Cell cultures I 238

Cell lines I 238 ~ Diploid cell lines I 238 ~ Primary I 238 Cell cycle II 752 Cell membrane II 1065, 1093

Adenylcyclase II 1077 Adhesion II 1068 ~ Ionic milieu II 1068 ~ Potential barrier II 1068 Adhesive substances II 1069 Aggregation II 1069 Amphipatic protein II 1078 Binding to agglutinin II 1079 Binding to IgG II 1079 Cancer II 1081

Adhesiveness II 1081 ~ Agglutination II 1081

Subject Index

Charge II 1081 Enhanced transport II 1081 Glycoproteins II 1081 Loss of communication II 1081 Loss of contact inhibition II 1081 Sialic acid II 1081 Tumor antigens II 1081

Capping II 1079 Carrier-mediated transport II 1066 Cell periphery II 1078 Chemotactism II 1067 Concavanalin A II 1069 Contact guidance II 1067 Contact inhibition II 1067, 1068, 1079 Cross-link II 1079 Disaccharidases II 1067 Disaccharide intolerance II 1067 Enzymes II 1065, 1074

p-glactoside permease II 1074 Diglyceride kinase II 1074 Neuraminidase II 1079 Phosphohydrolases II 1075 Sodium-potassium-sensitive ATPase

II 1074 Erythrocyte ghosts II 1072 ~ Glycophorin II 1073 ~ Protein II 1073 ~ Sialic acid II 1073 Exchange diffusion II 1066 Facilitated diffusion II 1066 Feedback mechanism II 1065 Flip-flop motion II 1078 Free diffusion II 1066 Genome II 1065 Glycolipid II 1069 Glycoprotein II 1080 Glycosidic linkage II 1080 Hormones II 1078 Hydrolases II 1079 Microfibrils II 1067 Microtubules II 1079 Molecular composition II 1072 ~ Erythrocyte ghosts II 1072 Molecular organization II 1075

Carrier mechanism II 1077 Cytochrome bs II 1076 Danielli model II 1075 Gramicidin A II 1077 Iceberg model II 1076 Lipid layers II 1075 Mitochondria II 1075 Rhodopsin II 1076 Subunit theory II 1075 Valinomycin II 1077

Movements II 1065, 1067 Pinocytosis II 1066 Plasminogen II 1079 Pores II 1066 Potassium sodium ATPase II 1078 Proteins II 1078 Receptors II 1066, 1079 Ruffled edge II 1067 Sodium potassium ATPase II 1067 Synthesis II 1078 Transport II 1065 Virus II 1078

Cell periphery, ~ Actin-like microfilaments II 1078 ~ Microtubules II 1078 P Cells 1497 ~ Fibrosis I 497 ~ Hyalinization I 497 Cellular communication II 1070

Calcium II 1070 ~ Colicine II 1071

Subject Index

Desmosomes II 1070 Electric current II 1070 Electric organ II 1070 Gap junction II 1070 Permeases II 1071 Potassium concentration II 1071 Regenerating liver II 1071 Sodium pump II 1071 Tight junction II 1070

Cellular death 1470, 607; II 613 Actinomycin D II 614 Aging red cell II 619 0(1-antitrypsin deficiency II 633 Biology I 607 Cloudy swelling II 627 Conclusion II 634 Cyclic AMP II 630 D-galactosamine II 629 DNA synthesis II 613 Ethionine II 616 Hydrolases II 620 Ischemia II 616, 628 Membrane lesions II 617

Irreversibility II 618 Ischemia II 618 Lysosome II 618 Mitochondria II 618 Osmotic shock II 618 Phalloidine II 619

Membrane permeability II 617 Mitomycin II 614 Oxidative phosphorylation II 616, 617 Phosphatidylcholine level II 619 Point of no return I! 627 Provoked II 629 Red cell I 608 Rifamycin II 614 Sodium pumping II 617 Source of energy II 616 Spherocytosis II 619 Spontaneous II 629 Tannic acid I! 716 Trypsin I 630 - Pancreatitis II 630 UTP depletion II 614

Cellular life span I 607 Centromere 1234 Ceramides I 188 - Biosynthesis I 188 Cerebellar ataxia I 270 Cerebrosides I 193 - Biosynthesis I 193 Ceroids I 315 Ceruloplasmin I 159 Cervical cancer II 1026 CFU 1373 Chalone II 916

Epidermal II 916 Erythrocytes II 916 Fibroblasts II 916 Granulocyte I! 916 Lymphocytes II 916 Rat liver II 916

Chondroitin sulfates II 934 Charcot-Marie-Tooth disease II 668 Chelate I376 - Hemoglobin I379 - Peroxidase I 379 Chemiosmotic coupling I 53 Chemoreceptor I 579

Aortic 1579 Carotid bodies I 579 Low levels of oxygen I 580 Partial pressure oxygen I 580

Chemotactism II 1067 Chemotaxis II 779

Actin filamen t II 782 Acute glomerulonephritis I! 781 Bacteria II 781 Calcium II 782 Glycolysis II 782 Hodgkin's disease II 781 Immunological vasculitis II 781 Magnesium II 782 Membrane II 781 Microtubules II 782 Mononuclears II 782

-- Plants II 781 Chemotherapy II 1005 Chloride metabolism I 570 - Alkalosis I 570 Chlorosis I 363 Chlorpromazine I 52 Cholestasis 1601 - Pathogenesis I 602 Cholate synthesis I 587 Cholycystokinin I 262 Cholesterol 1271 - Cholestyramine I 599 - Formula I! 692 Cholesterol esterification II 704 Cholesterol metabolism I! 692 -- Control II 1050

- Absorption I! 1051 - HMG-CoA reductase II 1052 - - Posttranscriptional control I! 1052 - HMG-CoA synthesis II 1051 - Sterol biosynthesis II 1052 Endogenous II 693 Esterification II 692 Exogenous II 692 Mevalonic acid formation II 693 Regulation II 696 - Cyclic AMP II 696 - Squalene sterol carrier protein II 696 Sitosterol II 692 Squalene formation I! 694

Chromatin II 1056 Chromosomal anomalies I 233

Acetylaminofluorene I 240 Acquired I 238 - Viruses I 238 Autosomal transmission 1233 Cold shocks I 239 DDT 1240 Dominant transmission I 233 Hexachlorophene I 240 Ionizing radiation I 239

-- Magnetic fields I 239 Mosaicism I 236 Nondisjunction 1236 Recessive transmission I 233 Ring chromosome I 239 Sound waves I 239 Teratogens I 238 Thalidomide I 240 Translocation 1236, 240 Trisomy I234 Ultraviolet light 1239

Chromosomal trisomies 1235 Chromosomes I 104

Breaks 1241 Centromere I 234 Chemistry I 88 Chromatid 1234 Color Blindness I 85 Crossing over I 86 Dicentric I 239 DNA 1104 Genetics I 84

Hemophilia I 85 Histones I 89 Linkage 186 Morphology I 84 Nucleic acid I 88 Nuclein 188 Protamines I 88 Protein r 88 Ring 1239 Ultrastructure r 104

Chronic renal disease r 592 Chvostek's sign I354 Chymotrypsin I 256, 403 Chymotrypsinogen I 257 - Activation I 258 Cirrhosis 1321, 555 - Gross findings II 648 - Portal gross findings II 648 - Postnecrotic II 648 Citrate synthetase II 1048 Citric acid I 54 Clathrate I 550 Clefts of Schmidt-Lanterman I! 664 Cloudy swelling II 627 - Diphtheria toxin II 627, 628 - Protein synthesis I 628 CIl-cis-retinol I 305 Coenzyme A I 277 - Biosynthesis 1277 - Ovaries I 277 Coenzyme Q I 43, 317 - Reductase I 44 Colchicine I 106, 224; I! 1064 Collagen I 279,281,550; II 924

Basement membranes II 926 Biosynthesis II 931

Cross-linking II 931 Cytochalasin B II 932 Galactose II 932 Glucosylgalactose II 932 Glycine tRNA II 931

VI!

Peptidyl galactosyl hydroxylysine transferase II 932 - Peptidyl glucosyl galactosyl hydroxy­lysine transferase II 932 - Peptidyl lysine hydroxylase II 932 - Peptidyl proline hydroxylase II 932

Po Iysomes II 931 Pro 0( chains II 931 Procollagen II 931 Proline tRNA II 931 TropocolJagen II 931 Tubular system II 932

Breakdown II 932 - Collagenase II 932 0(1 Chain II 925 Cross-links II 927, 928

Allysine II 929 - fJ-mercaptoethylamine II 929 - Copper II 929 - Dehydrohydroxylysinorleucine II 929

Hydroxylysinorleucine II 929 Hydroxylysine II 929 b-hydroxylysinorleucine II 929 Lysinorleucine II 929 Penicillamine II 929 Pyridoxal deficiency II 929

Disease II 932 - Decreased proline hydroxylase activ­ity II 934

Decreased soluble collagen II 934 Dermatosparaxis II 933 Ehlers-Danlos syndrome II 934 Hydroxylysine deficiency II 933

VIII

Collagen, Disease, Increased glycosyl transferases II 934 - Increased proline hydroxylase activ­ity II 934 - Lysine oxidase II 933 - Osteogenesis imperfecta II 933 Molecule II 924

Models II 925 Sequences II 925 - Apolar II 925 - Polar II 925 Soluble II 934 Suprahelix II 926 Tripeptide II 925 Triple helical structure II 926

Collagenase II 932 Colon carcinoma II 1100 Colony inhibition test II 1102 Color blindness I 85, 86 Compensatory polycythemia in methemo­

globinemia I 155 Complement II 813

Activation II 813 - binding of C4b II 814 - C3b peptidase II 815 - splitting of C3 Activation of CI II 813 Activation of C2 II 814

Complex ion I 376 Concavanalin A 1521; II 1069 Condroitin II 934 Cones 1310 Conformational coupling I 53 Congenital anomalies I 276, 308 Contact guidance II 1067 Contact inhibition II 1068, 1094 Convulsion I 354 Coombs' reaction II 841 Copper I 42, 159 - Tyrosinase I 174 Copper metabolism I 160

Ceruloplasmin I 162 Copper and blood I 162 Copper bound I 162 Erythrocuprein I 162 Polypeptides I 162

Coproporphyrinogen I I 205 Cordycepin II 615 Coronary occlusion II 705 Corticoid hormones I 467

Metabolic effects I 467 A TP synthesis I 468 Eosinophilia 1471 Erythropoiesis 1471 Gluconeogenesis I 468 Glycogen synthesis I 468 Lipid metabolism I 469 Lipogenesis I 469 Lymphopoietic tissue I 469 Mitochondrial swelling I 468 Monocytes 1471 Nitrogen balance 1467 Nucleic acids 1470 Protein metabolism 1467 Protein synthesis 1470 Pyruvate carboxylase I 469 Receptors 1471

Corticosteroid hormones 1491 Adrenogenital syndrome I 492 - Androgens I 493 Inborn errors 1491

Adrenogenital syndrome I 492 - Cryptorchidism I 492 - 21-hydroxylase deficiency 1492 - 3 f3-hydroxysteroid dehydrogenase deficiency I 492

Inborn errors of metabolism 1491 - II f3-hydroxylase deficiency I 493 - 171X-hydroxylase deficiency 1493 - Hypospadias I 492

Councilman bodies II 1003 Countercurrent exchange I 545 Coupling factors I 51 Coupling mechanisms 147 Covalent bond, coordinated I 376 Crabtree effect II 1044, 1045 Cretinism I 457

Abnormal peroxidase I 458 - Iodine deficiency I 458 - Iodine pumping mechanism I 458 - TRH deficiency I 458 Creutzfeldt-lakob disease II 1009 Cri-du-chat syndrome I 237 Crohn's disease II 885 Cross-links II 927, 928 - f3 Aminopropionitrile II 931 - Lathyrism II 930 - Soluble collagen II 931 Crotonase I 55 - Reactions I 56 Croton oil II 987 Cryptorchidism II 966 Crypt of Lieberkiihn, Alkaline phospha-

tase I 322 - Hexose monophosphate shunt I 323 - Proliferation I 323 Cushing's syndrome 1477; II 1096

Adenocarcinoma 1477 Adenoma 1477 Anephrotensin 1478 Adrenal hyperplasia 1477 Basophilic adenoma 1477 Cortisol levels I 478 Diabetes 1479 Hypertension 1478 17-hydroxycorticosteroid 1478 Moon-faced 1478 Nitrogen balance 1478 Obesity 1478 Osteoporosis 1478 Skin 1479

Cyanosis and methemoglobinemia I 155 Cycasin II 983 Cyclic AMP 1455, 529, 559; II 988, 989,

1022, 1048, 1088 ACTH 1530 Adenyl cyclase 1529 Cell division I 532 Enzyme turnover 1531 Epinephrine I 530 Glucagon I 530 GTP 1530 Histones I 530 Insulin I 530 Metabolism I 530 Phosphodiesterase I 529, 530 Phosphofructokinase I 531 Phosphoprotein phosphatase 1531 Protein kinase I 530, 531 Psoriasis I 532 Receptor I 531 Steroid metabolism 1531 Translation I 530

Cyclic GMP 1531; II 988, 989 - Guanylate cyclase 1531 Cyanide 142 Cyclohexamide I 66 Cystathioninuria 1232 Cystine I 229 Cystinosis I 231 Cystinuria I 229, 594 - Arginine I 229

- Cystine stone I 230 - Lysine I 229 - Ornithine I 229 Cystic fibrosis I 241, 320

Atelectasis I 321 Cirrhosis I 321 Fatty liver I 321 Mucus secretion I 321 Pathogenesis I 321

Subject Index

Portal hypertension I 321 Cytochrome I 37, 40 Cytochrome bs 136; II 1076 Cytochrome c I 36, 37; II 1032 - Amino acid sequence I 38 Cytochrome oxidase 141 - Nucleus 184 Cytochrome P4S0 141 Cyto lysis II 840 Cytomegalovirus I 1003 Cytoplasmic alteration, viruses II 1001

Deamido NAD 1274 Debye units I 547 Decarboxylase in maple syrup disease

I 181 Defective leukocytic response II 791

Chediak-Higashi's disease II 791 Erythroleukemia II 791 Granulocytopenia II 791 Hodgkin's disease II 791 Lazy leukocyte syndrome II 791 Leukemia II 791 Leukotactic defects II 791 Polycythemia II 791

Dehydration I 546, 584 - Hyposmolarity I 584 Deiodination 1422 - Tetra- and triiodo-derivatives I 443 Dementia 1271 Demyelination I 267; II 668

Allergic encephalitis II 668 - Axon degeneration II 668 - Electron microscopy II 668 - Multiple sclerosis II 669 De novo pathway II 1037 De novo synthesis with isotopes I 82 Dermatosparaxis II 933 Dexamethasone receptor I 528 Diabetes I 247, 272, 277, 326, 479, 495;

II 700, 1047 Alloxan I 513, 514 Anti-insulin 1497 Fatty acid synthesis I 523 Growth hormones I 507 Insipidus 1437; II 1096 Ketosis I 522 Pathogenesis I 524 Pathology, f3 cells 1496 Phosphopyruvic carboxylase I 525 Clinicopathological correlation 1496

By increased diuresis I 496 Dehydration I 496 Electrolytes I 496 Fatty acid metabolism 1496 Glucosuria I 496 Hyperglycemia I 496 Ketone bodies I 496 Polydypsia I 496 Protein I 496 Urine nitrogen 1496

Complications I 498 Abnormal delivery I 498 Amyotrophies 1501 Arteriosclerosis I 498 Cataracts I 498, 50 I Glomerular nephrosclerosis I 498

Subject Index

Infections I 498, 501 Neuropathy I 501 Osteopathies I 501 Po Iyneuri tis I 498 Pseudoerythroblastosis I 501 Retinitis I 498 Xanthelasmas I 498

Glomerulonephrosclerosis I 499, 500 - Glycoproteins I 499 - Kimmelstiel and Wilson disease 1499 Onset 1495

Diseases I 496 Dietary habits I 496 Hemochromatosis I 496 Lithiasis I 496 Pancreas carcinoma I 496 Pancreatectomy I 496 Pancreatitis 1496 Stress 1496

Dialysis disequilibrium syndrome I 566 Diamine oxidase I 301 Diatomic molecule I 376 Dicumarol I 42 Dihydrouridine 1110 1,25-dihydroxycholecalciferol 1343 Dihydroxyphenylalanine in phenylketuno-

ria 1174 Diiodothyronine, deiodination I 442 Diiodotyrosine, Deiodination I 442 Dimers, function II 731 Diphosphopyridine nucleotide (NAD) I 33 Diphtheria toxin II 1008 - Electron transport II 1009 - Iron II 1009 - Protein synthesis II 1009 Dipole moment I 547 Direction of reading message I 128 Disaccharidases II 1067 Disaccharide intolerance II 1067 Disseminated coagulation 1419,420

Afibrinogenemia I 420 Azotemia 1421 Cor pulmonale I 420 Dypsnea 1420 Ecchymosis I 420 Endocarditis I 421 Hemorrhagic diathesis I 420 Ischemia I 420 Necrosis 1420 Oliguria 1421 Pathogenesis I 421 Petechiae I 420 Shock 1420

DNA 193 Base composition I 98 Base pairing I 99 Bouyant density 198 Cancer 194 Chemistry I 97 Content and nucleus I 93 Erythroblasts I 94 Guanine-cytosine I 98 Histones I 91 Intestinal polyps I 94 Megaloblast I 94 Nearest neighbor bases I 101 Okazaki fragments I 102 Unwinding protein I 102 Watson-Crick model I 99

DNA methylase I 114 - S-Adenosyl methionine 1114 DNA Polymerase I 101 - Nucleus 183 DNA repair II 727, 990 - Aging II 732

Bloom syndrome II 732 Chemical carcinogenesis II 990 Disease II 731 Excision repair II 728 Fanconi syndrome II 732 Hitchinson-Gilford syndrome II 733 Postreplication repair II 730 Progeria II 733 Thymine dimers II 728

DNA Replication 1100 - Enzymic mechanism I 100 - Semiconservative I 100 DNA synthesis II 1064 Donnan body fluids I 539 Donnan law I 568 Dopa decarboxylase I 174 - Phenylketonuria I 174 Dopamine-fJ-hydroxylase 1225 Down's syndrome I 236, 237 - Nondisjunction I 236 Drosophila I 85

Chromosomes I 85 - Red eye 185 - White eye I 85 Drug induced hemolytic anemia I 170

Balanced polymorphism I 170 Glutathione peroxidase I 171 Glyoxalase I 171 Heinz bodies I 170 Hyperbilirubinemia I 170 Jaundice I 170 Lifa span of the red cell I 171 Malaria I 170 Naphthalene I 170 Primaquine I 171 One gene, one enzyme theory I 171 Sulfanilamide I 170 Vitamin K 1170

dsRNA 1121 Duane equation II 717 Dumping syndrome, - Bradykinin 1319 - Pathogenesis 1319 Duodenal ulcers 1276, 314 Dwarfism I 432

Achondroplasia I 433 - Hereditary I 433 - Malnutrition I 433 - Pituitary, acquired I 433 Dwarf mice I 433

Edema I 546, 582 Central nervous system lesions I 582 Cyclic idiopathic I 584 Pulmonary I 582 - Anoxemia I 482 - Lymphatic obstruction I 582 - Pathogenesis I 582 Salt and water retention I 583 Systemic I 583 - Pathogenesis I 583

Effect of thyroid hormone I 445 Calcium I 446 Chloride I 446 Diabetes I 446 Electrolytes I 446 Electron transport I 446 Gluconeogenesis I 446 Glucose metabolism I 446 IX-glycerophosphate shuttle I 448 Iron 1446 Magnesium 1446 Mitochondria I 447 NADPH concentration 1447 Nitrogen metabolism 1445 Oxygen consumption I 448

Oxygen uptake I 446 Potassium I 446 Sodium 1446 Transhydrogenase I 448

Ehlers-Danlos syndrome II 934 Einstein-Planck equation II 717 Elastase I 256 Elastin II 929

Cross-links II 929 Desmosine II 929 Fibroblasts II 930 Smooth muscle cells II 930

Electric organ II 1070 Electron transport I 317; II 1034 - Antimycin I 44 - Chain 144; II 1009, 1031 - Oxidative phosphorylation I 45 - Mitochondrion I 45 Electrolytes I 539 Electrodialysis 1376 Electrophilic reagent I 50 Electron II 717 Emboli 1415,418

IX

Endochondral ossification I 279 Endoplasmic reticulum I 133, 587; II 646

DNA content I 135 Morphology I 133 Nuclear membrane 175 Origin 1135 Role in protein synthesis I 134 Rough 1135 Smooth 1135

Enolase, nucleus I 80 Enzyme, nucleus I 83 Enzyme turnover 1531 Eosiniphilic adenoma I 429, 430 Eosinophils II 788 - Cortisone II 788 - Granules II 788 Epinephrine I 530 - Receptors I 528 Epinine in phenylketonuria I 174 Epitheliomesenchymal interactions II 938 - Mammary gland II 938 - Pig epithelium II 938 - Salivary glands II 938 Erb's sign I 354 Ergot preparation I 208 Erythroblast, DNA content I 94 Erythroblastosis fetalis II 844 - Host-versus-graft reaction II 845 Erythrocuprein I 162 Erythrocyte ghosts II 1072 - Lipids II 1072 - Plasmalogens II 1072 Erythron I 371 Erythropoiesis 1372

Colony forming units, CFU I 373 - Erythropoietin I 373 - Polycythemia 1373 - Porphyrin I 373 Erythropoietin I 373, 557 Esophagus cancer II 110 Essential amino acids I 265 Estrogen I 247 - Cancer II 962, 966 - Leiomyoma II 963 - Ovaries I 480 Exophthalmia I 452 Eye in Gaucher's disease I 191

Fabry's disease I 233 - Pathogenesis I 198 - Telangectases I 198 Factor XIII deficiency I 408 Factor M I 119

x

Factor T 1119 Familial imino glycinuria 1232 Fanconi syndrome II 732 Famesoate II 694 Famesyl pyrophosphate II 694 Fat absorption,

Bile acid II 685 Chylomicrons II 686 Heparin II 686 Lipoprotein lipase II 686 Pinocytosis II 686

Fat metabolism, fat absorption II 685 Fattyacid II 1048

a-Oxidation 159 Acetyl-CoA-ACP transacylase 162 Acyl dehydrogenase I 55 ATP lyase 161 Avidin 161 B-hydroxyacyl-ACP dehydrase I 62 B-Ketoacyl-ACP-reductase 162 B-Oxidation pathway I 54, 55 Biotin 161 Branched oxidation I 57 Butyryl dehydrogenase I 55 Citrate 161 Crotonase I 55 Cyanide 155 Hydroxyacyl dehydrogenase I 56 Intracellular distribution I 57 Ketoacyl thiolase I 57 Ketosis 155 Malonyl CoA-ACP transacylase I 62 Maple syrup disease I 57 Methylglutaconase I 57 Minimal deviation hepatomas 161 Mitochondria I 55 Oligomycin I 55 Palmitaldehyde dehydrogenase I 55 4'-phosphopantothenic acid 162 Shuttle II 644 Synthesis I 60; II 646 - in Mitochondria I 60 Synthetase 161, 62 Thiokinase 155 w-Oxidation 159

Fatty Acid Oxidation I 54 Acetoacetyl-CoA 154

- Acetyl-CoA 154 - Citric acid 154 - Thiokinase I 54 Fatty liver 1264, 321 Ferritin I 363 - Apoferritin 1364 - Biosynthesis I 363 - Structure I 363 F errochetalase I 206 Fetal liver I 175 Fetus II 830

Bioenergetic pathway I 248 Blastocyst II 830 Carbohydrate oxidation I 248 Decidua II 830 Fat 1249 Fat Oxidation I 248 Glucose oxidation 1248 Glucose-6-phosphatase I 249 Hexokinase I 249 Lactic dehydrogenase I 249 Oxygen consumption 1248 Phosphofructokinase I 249 Phosphorylase I 249

- Protein synthesis I 250 - Trophoblast I 830 - Tryptophan pyrrolase 1248 Fibers of Remak II 664 Fibrin 1399

Cross-linking 1405 Factor LLF I 406 Factor XIII 1406 Fibrinase I 405 Hyperfibrinogenemia 1415 Polymerization I 405

Fibrinase 1405 Fibrinogen I 158, 399, 403

Amino acid sequence 1403 Conversion to fibrin I 404 Fibrin or peptides 1404 Sialidase I 403

Fibrinoid necrosis II 660, 116, 879 Fibrinolysis 1413 - Fibrinogenase 1413 - Nicotinic acid 1414 Plasma, hyperproteolytic activity 1415

Plasmin 1413, 414 Plasminogen 1414 Pseudomembranes 1414 Streptokinase 1414 Urokinase 1415

Fibrinopenia, Blood coagulation 1408 Fibroadenoma II 948 Fibroblasts 1279 Flavin adenine dinucleotide pyrophospho-

rylase I 35 Flavokinase 135 Fluorapatite I 336 Fluoride, inhibition of initiation I 129 Fluorocytes I 206 Fluorene derivatives II 980

Acetylaminofluorene II 980 Active carcinogens II 982 Chelates I 983 Effect of diet II 981 Hormones I 981 Metabolism II 982 - Deacylation II 982 - Hydroxylation II 982 N-hydroxy-2-acetylaminofluorene 11980 N-hydroxyl metabolites II 982 Other carcinogens II 981 Substitution II 980

Acetamide II 980 - Halogen II 980 - Hydroxyl II 980 - Sulfur group II 980

Fluorene derivatives II 979 - Hyperplastic nodules II 983 - Liver changes II 983 Foam cells II 711 Focal cytoplasmic degradation 11624 Folic acid 1294 - Aminopterin I 294

Anhydride of hydroxymethyl THF A 1294 Citrovorum factor I 294 Deficiency I 297 - Megaloblast I 297 - Methotrexate I 297 Deoxycytidylate hydroxymethylase 1296 Dihydrofolic acid reductase I 294 Folic acid reductase I 294 Formyltetrahydrofolate synthetase 1294 Formiminotetrahydrofolic acid cycio­deaminase I 296 Formininotransferase 1295 L-serine hydroxymethyltransferase 1296 Metabolism 1295 N-formyl, 5,6,7,8-tetrahydrofolic acid 1294

Subject Index

N 5-formyltetrahydrofolate isomerase (cyclodehydrolase) 1295 N 5, N10-methyltetrahydrofolate cyclo­hydrolase I 294 Pteroylglutamic acid I 294 Serine hydroxymethyltransferase 1296

Forbes' disease (see glycogen storage dis-ease) I 165

Formyl methionyl tRNA I 129 N-formyltetrahydrofolic acid I 294 Free radicals II 639, 640, 985 Friend virus II 10 13 Frohlich's syndrome 1432 Fructoaldolase I 170 Fructokinase I 170 Fructose diphosphatase II 1046 Fructosuria I 169

Fructoaldolase I 170 - Fructokinase I 170 - Phosphoglucomutase I 170 FSH 1487 Fumarase I 30

Galactosemia I 167 Acetonuria I 167 Aminoaciduria I 167 Bilirubin I 168 Cataracts I 169 Cerbrosides I 168 Fatty Liver I 168 Galactosuria I 167 Hepatomegaly I 167 Mental Deficiency I 168 Pathogenesis I 168, 169 Pathology I 167 Phosphoglucomutase I 168 Polyuria I 167 Transferase Deficiency I 169

Galactose metabolism, Regulation I 169 Galactose synthesis I 168 Gallbladder I 599 Gallstones I 599 - Pathogenesis I 600 Gammaglobulinopathies II 882 - Heavy-chain disease II 882 - Light-chain disease II 882 Gammopathies, Polyclonal II 885 Ganglioside and ceramides I 188 . Breakdown I 185

Sialic acid I 186 Sphingosine I 186 Structure I 189 Unsaturated fatty acid I 185

Ganglioside structure and metabolism I 185

Ganglioside tissue fractionation I 188 Gastrectomy I 286 Gastric glands I 255 Gastric juice I 255 Gastrin I 260 - Amino acid sequence 1261 Gastrin secretion I 260 - Acetylcholine I 260 - Gastrin I 260 - Gastrones I 261 Gastric section, Control I 259 Gastrones I 261 Gaucher's disease I 191

Acid phosphatase I 193 Cerebrosides I 192, 193 Eye I 191 Galactolipids I 192 Globoside I 193 Glucosidase I 193 Liver cells 1191, 192 Pathogenesis I 198

Subject Index

- Pigmentation 1191 Genes 1130 Gene expression II 1052

Activator II 1059 Cancer cell, Reversion II 1065 Cell differentiation II 1053 - Pancreas II 1053 - Predifferentiation stage II 1054 Cell division II 1062 Cell hybridization II 1061 Chromatin II 1056, 1059 Chromosomal RNA II 1058 Colchicine II 1062, 1064 Corticoid receptors II 1061 Cyclic AMP II 1056, 1058 Differentiated stage II 1054 DNA II 1059 - Reassociation II 1059 - Synthesis II 1053, 1064 Enzyme induction, Tyrosine amino­transferase II 1054 Gene batteries II 1060 Generationcycle II 1062 Hepatomas II 1055, 1059 Histones II 1059 Integrator gene II 1059 Isolated hepatocytes II 1056 Liver regeneration II 1063 Messenger RNA II 1060 Nonhistone chromosomal protein II 1057, 1059 Nuclear transplantation II 1061 Pancreas regeneration II 1063 Polyribosome II 1064 Prodifferentiation stage II 1054 Producer gene II 1059 Protein kinase II 1058 Receptors II 1055 Receptor gene II 1059 Redundant DNA II 1060 Regulatory protein II 1060 Repetitive sequences II 1060 Repressor II 1056 Sensor gene II 1058, 1059 Sodium II 1064 Spindle II 1064 Structural gene II 1060 Structural messenger II 1060 Transcription regulation II 1060 Translation II 1060 Translation control II 1060 tRNA II 1061 Vinblastine II 1062

Generalized gangliosidosis I 190 Germinal gland, histogenesis 1479 Gigantism 1430 Gilbert's disease I 393 Gliadin I 323 Globin 1145 Globoid lipoidosis (see Krabbe's disease)

1196 Globoside, Gaucher's disease 1193 Globulin 1158 Glomerular filtration, Autoregulation

1543 Glomerulonephritis II 781

Acute streptococcal II 865 Antigen-antibody complex II 861 Anti-glomerular membrane II 861 Chronic II 865, 866 Diffuse II 865 Focal II 865 Goodpasture II 863 Goodpasture's syndrome II 862, 866 Human II 861 Malignant progressive II 865

- Renal transplant II 863 - Streptococcal II 862 - Subacute II 866 Glomerulosa cells I 554 Glucagon 1326, 506, 513, 530; II 1048 - Ketosis I 507 - Receptors I 528 Gluconeogenesis 1504, 514; II 1045

ADP II 1046 ADPjATP ratio II 1048 AMP II 1046 ATP II 1046 Biotin II 1046 Citrate synthetase II 1048 Cyclic AMP II 1048 Diabetes II 1047 Diphosphatase II 1046 Fatty acids II 1048 Fatty acyl CoA II 1048 Fructose diphosphatase II 1046 Glucagon II 1048 Glucose II 1047, 1049 Glucose administration II 1049 Glucose-6-phosphatase II 1046 Glutamate oxaloacetate transaminase II 1048 Hepatocytes II 1049 Hexokinase II 1046 Malic enzyme II 1047 Mitochondria II 1048 NADHjNAD ratio II 1048 Oxaloacetate II 1046 Phosphocarboxykinase II 1046 Phosphofructokinase II 1046 Pyrophosphate II 1047 Pyruvic carboxylase II 1046, 1047 Pyruvic kinase II 1046, 1047 Regulation in vivo, Pyruvic carboxy­lase II 1047

Glucoreceptors I 326 Glucosekinase II 1084 Glucose I 545 - Carrier 1545 - Reabsorption I 545 Glucose metabolism, Hormonal control

1505 Glucose-6-phosphatase II 640, 1042, 1046 - Fetus 1249 - Infancy I 250 Glucose-6-phosphate dehydrogenase, Pen-

tose phosphate pathway I 21 Glucose tolerance I 283; II 1096 Glucose transport I 545 Glucose uptake I 514 Glucose uptake in brain 1514 Glucose uptake in lens I 514 Glucose uptake in tumor cells 1514 Glucosidase, Gaucher's disease 1193 Glucosuria, Renal I 545 Glucuronic acid cycle I 24 Glucoronic pathway I 282 - Intracellular distribution I 25 P-glucuronidase II 626, 937 Glutamic aspartic transaminase I 300 Glutamine I 588 Glutamine synthetase I 588 Glutathione reductase I 369 Glutathione synthesis 1588 Glutathione transferase II 976 Glycerokinase 1519 ex-Glycerophosphate shuttle II 644 Glycine Oxidase I 36 Glycogen metabolism 1164

Control II 1049 5'-AMP II 1049

- Anoxemia II 1050

XI

- Calcium II 1050 - Glucose-6-phosphate increase II 1050

Glycogen synthetase II 1049, 1050 Kinase-activating factor II 1049 Phosphorylase II 1049 Trypsin II 1050 UDP-glycogen glycosyl transferase

II 1049 - Von Gierke's disease II 1050 Glycogen synthetase, Phosphorylation II 1050

Glycogen storage disease I 163 Anderson's disease 1166 Branching enzymes I 166 Convulsions 1164 Forbes' disease I 165 Glucose-6-phosphatase I 164 1,6-glucosidase I 165 Glycogen in liver I 165 Hers'disease I 166 Hyperlipidemia 1164 Ketosis I 164 McArdle's disease 1166 Pathogenesis I 166 Phosphorylase I 166 Phosphorylase kinase I 166 Portocaval transposition I 165 Types 1167 Van Gierke's disease 1164

Glycogen synthesis, Control, Glycogen syn­thetase II 1050 Active II 1050 Calcium II 1050 Inactive II 10 50 Phosphorylation II 1050 Trypsin II 1050

Glycolipid II 1069 Glycolysis 1514; II 1045

Control II 1042 Allosteric regulation II 1043 Crossover II 1042 Cyclic AMP II 1043 Fluoroacetate II 1043 Glucose II 1042 Glucose phosphatase II 1042 Phosphoenolpyruvic carboxy kinase

II 1042 - Phosphofructokinase, Polymeriza­tion II 1042, 1043 - Pyruvic carboxylase II 1042 - Pyruvic kinase II 1042 Nucleus 180

Glycoproteins II 1080 Biosynthesis, Transferases II 1080

- Receptors II 1080 - Regulation of growth II 1080 - Sialyl transferase II 1080 Glycosyl transferase II 934 Golgi apparatus I 135

A TP sulfurylase I 136 Galactosyl transferase I 136 Glycoprotein biosynthesis I 136 Lysosomal enzymes 1136 Sulfation I 136 Sulfa transferase I 136

Gonadotropin, elaboration II 1096 Gout 1218, 546, 594

Allopurinol I 224 Benamide I 224 Colchicine 1224 Feedback inhibition I 223 Glutaminase I 223 Glutamine PRPP Amidotransferase 1223 Glutamine synthetase I 223

XII

Gout, Indomethacin 1224 Methylguanine 1218 I-methylguanine 1218 7-methylguanine 1218 methyl-8-hydroxyguanine 1218 I-methylhypoxanthine 1218 N, 2-methylguanine 1218 Pathogenesis 1221 Phenylbutazone 1224 Phospho ribosyl transferase I 223 Therapy 1224 Tophi 1219 Urate crystals 1220

Graffi vi rus II 1012 Graft-versus-host reaction II 840 - Cytolysis II 840 - Secondary disease II 840 - Wasting disease II 840 Gramicidin II 1077 Granulocytes II 1088 Graves' disease 1451

Diarrhea I 452 Excitability 1452 Exophthalmia I 452 Increased basal metabolism 1452 Iodine 1452 Muscle wasting 1452 Pathogenesis 1455 - LATS 1456 - Receptors I 456 Pathology 1451 Protein bound iodine 1451 Symptoms 1451 Tachycardia I 452 Thymicolymphatic state 1453 Thyroid bound globulin 1451 Thyroid bound proalbumin 1451 Thyroxine I 452 Vomiting 1452

Griseofulvin I 106 Gross virus II 1012 Ground substance II 934

Biosynthesis II 936 Chondroitin II 934 Chondroitin sulfates II 934 Heparin sulfate II 934 Hyaluronic acid II 934 Keratinosulfates II 935 Keratosulfate II 934 Marfan's syndrome II 934 Polysaccharide II 936 PPL fraction II 935 Protein-polysaccharide complexes 11935

Growth factors II 914 Epidermal growth II 914 Erythropoietin II 914 Fetuin II 915 Lymphocytic proliferation II 914 Nerve II 914 - Microfilaments II 915 - Microtubules II 915 Receptors II 914 Submaxillary gland II 914 Zeatin II 915

Growth Hormone I 425, 507 Amino acid sequence 1426 Insulin effect I 427 Metabolic effect 1427 - Amino acid and protein synthesis 1428

Anti-insulinic effect 1427 Calcium I 429 Carbohydrate metabolism 1427 Electrolytes I 429 Fatty acid synthesis 1428

Glucose uptake I 427 Glucose uptake in muscles I 427 Hexose monophosphate shunt 1428 Insulin effect I 427 Ketosis I 428 Lipid metabolism I 427 Lipid mobilization 1428 Nitrogen balance 1428 Phosphorus I 429 Potassium I 429 Sodium 1429

Receptors I 429 Releasing factor I 429 Sulfating factor I 431

Growth regulation II 1080 GTP, Purine metabolism 1214 Guanine 1210 Guanine hypoxanthine phosphoribosyl

transferase I 225 Guanylate cyclase 1531 Guarnieri's bodies II 1003 Gulonolactone oxidase I 25

H 2 '80-ATP Exchange reaction 152 H 2 '80-Pi Exchange reaction 152 H 25S protein 11978 Hageman factor deficiency I 407 Hand-Shiiller-Christian disease I 438 Haptenes II 837 Havers canal I 335 HCG 1487 Heart diaphorase I 36 Heinz bodies I 158 - Drug induced hemolytic anemia

1170 Heinz bodies in thalassemia I 158 Hematopoietic, Erythroblast I 366 Hematopoietic system I 366

Angioblast I 366 Erythron I 366 Hematopoiesis I 366 Megaloblast I 366 Megalocytes I 366 Red cells I 366

Heme 1145, 158 Iron 1206

- Myoglobin 1153 - Porphyria I 209 Heme in Thalassemia I 158 Heme synthesis I 302 Hemochromatosis I 383 - Pancreatitis I 383 - Xanthine oxidase I 383 Hemodialysis II 700 Hemoglobin I 145, 369

A 1146 C 1146 D 1146 Disease, clinical molecular correlation I 154 D punjab I 147 E 1147 Electrophoretic mobility I 147 F 1146 Fetal I 145 G 1146 G Honolulu I 147 G San Jose I 147 Georgetown I 147 Lepore I 146 M Boston 1147, 156 M Milwaukee I 147 M Saskatoon 1147, 156 Nomenclature I 145 Norfolk I 147 o Arabis 1147

Reabsorption I 546 S 1146, 147 S tactoids I 147 Structure I 153

Subject Index

Hemolytic anemia I 175, 391 Bone marrow I 391

- Hemosiderin I 391 - Urobilinogen 1391 Hemolytic Jaundice 1387 Hemophilia I 406 - Transfusion I 407 - Von Willebrand's disease 1406 Hemosiderosis I 379, 380, 381 - Alcoholism I 382 - Marchiafava-Micheli syndrome 1381 Hemosiderosis in Thalassemia I 157 Heparin II 686 Heparin sulfate II 934 Hepatic lobules I 60 I Hepatitis 11650

A II 651 B II 651 Chronic II 652 Clinical manifestation, Jaundice II 651 Drugs II 652 Viral II 650

Epidemic 11651 Experimental II 652

Heredity II 653 Immune reaction II 653 Kupffer cell II 653 Lysosomes II 653 Toxic II 654

Fulminant II 651 Serum hepatitis II 651

Hepatomas II 1031, 1059, 1082, 1100 Minimal deviation II 1031, 1082

Allosteric inhibition II 1085 Amino acid pool II 1085 Cholesterol biosynthesis II 1085 Enzyme induction II 1085 - Tryptophan pyrrolase II 1086 - Tyrosine glutaryl transaminase

II 1086 Glycolysis II 1084

Glucosekinase II 1084 Hexokinase II 1084 Ketone bodies II 1084 Velocity of growth II 1084 Histology II 1083

Isozymes, 5' -nucleotidase II 1087 Receptors II 1087

Hepatomegaly in galactosemia I 167 Hepatomegaly in thalassemia I 157 Hereditary angioneurotic edema II 858 Hereditary disease, Sickle cell anemia

I 145 Hermaphroditism 1491

Mosaicism I 491 - Ovotestis 1491 - Sex chromosomes 1491 Herpes virus II 1025 - Cancer II 962 Herpetic infection II 1008 Hers' disease (see Glycogen storage dis-

ease) I 166 Heterogeneous RNA I 121 - Cordycepin I 121 - dsRNA 1121 - snRNA 1121 Heterolytic fission II 639 Hexachlorobenzene, Porphyria I 209 Hexokinase II 1044, 1046, 1084

Conformation II 1045 Dimerization II 1045 Fetus 1249

Subject Index

Regulation II 1044 Conformation II 1045 Crabtree effect II 1045 Dimerization II 1045 Glucose-6-phosphate II 1044, 1045 Glycolysis II 1045 Lens II 1045 Muscle II 1045 Orthophosphate 111044

Hexosaminidase in Tay-Sachs disease 1190

Hexose monophosphate shunt II 1030, 1031

Hippuric acid synthesis I 587 Histamine II 768

Degranulation II 833 Metabolism II 768, 770

Diamino oxidase II 768 Histaminase II 768 Histamine AD II 769 Histidine decarboxylase II 768 Methylation II 769 Xanthine oxidase II 769

Release II 769 Cyclic AMP II 770

- Degranulation II 769 - Mast cells II 769 - Phospholipase II 770

Histidase in histidinemia II 179 Histidine deaminase I 179 Histidine decarboxylase II 768 Histidine degradation I 180 Histidine pathogenesis I 181 Histidine pyruvic transaminase in histidine­

mia 1179 Histidinemia I 179

Histidase I 179 Histidine pyruvic transaminase I 179 Imidazolone propionate hydrolase 1179 Urocanase I 179 U rocanic acid I 179

Histocompatibility II 845 - Genes II 839, 845 - Major II 845 - Minor II 845 Histones 189; II 919, 1056

After partial hepatectomy I 91 Amino acid sequence I 90 And DNA 191 Lysine 190 In simulated lymphocytes 190 Nomenclature 192 Phosphokinase I 91 Role and metabolism I 90

HL-A system II 846 Celiac disease II 848 Cross-reactions II 847 Disease II 847 Mixed-lymphocyte culture II 848 Transplantation II 847

HMG-CoA reductase II 1052 Hodgkin's disease II 781, 1025 Holotranscarboxylase I 280 Homocystinuria 1231 Homolytic cleavage II 639 Homoserine dehydrase 1301 Host-versus-graft reaction II 845 Houssay preparation 160 Hunger 1326 Hunter's syndrome II 938 Hurler's syndrome II 938 Hyalinization II 660 Hyaluronic acid II 934 Hydrocephalus I 308 Hydrogen bonds 1152, 547

Hydrolases II 620 Experimental necrosis II 623 Insect metamorphosis II 623 Necrobiosis II 622

Breast tissue II 623 - Mullerian ducts II 622 - Tadpoles II 622 _ Nucleus 183 Shock II 624 X-irradiation 11624

Hydrolases in autolysis II 621 Hydrolysine deficiency II 933 Hydronium iron I 571 Hydroxyacyl dehydrogenase I 56 B-Hydroxyacyl-ACP dehydrase 162 Hydroxyanthranilic acids I 274 3-hydroxyanthranilic acid I 272 3-hydroxyanthranilic oxidase I 272 25-hydrollycholecalciferol, formula I 343 17-hydroxycorticosteroid I 283 Hydroxyproline I 284 Hydroxylation of proline I 285 5-Hydroxymethylcytosine 196 Hydroxyphenylpyruvic hydroxylase I 283 Hydroxyprolinemia 1231 5-Hydroxytryptamine, Hypertension 11771 Hyper p-alaninemia 1231 Hyperbilirubinemia I 393 - Pernicious anemia I 393 - Drug induced hemolytic anemia I 170 Hypercalcemia 1351; II 1096 Hypercholesterolemia I 277 Hyperfibrinogenemia 1415 Hyperglobulinemia II 881 - Monoclonic II 882 - Polyclonic II 882 Hyperkalemia I 569

Heart failure I 569 - Muscular dystrophy 1569 - Myasthenia I 569 Hyperlipidemia II 710, 712

Abetalipoproteinemia II 711 Familial II 710 Foam cells II 711 Lipemic retinitis II 711 Pancreatitis 11711 Tangier disease II 711 Xanthoma II 710 Xanthomatosis tuberosa II 711

Hyperlysemia 1231 Hyperoxaluria I 270 Hyperparathyroidism 1350, 592, 594

Adenoma I 350 Bone atrophy I 351 Bone resorption I 352, 354 Carcinoma 1350, 351 Chief cell hyperplasia I 350 Hypercalcemia 1351 Hypertension I 352 Muscle excitability 1352 Nephrolithiasis 1351, 352 Nerve excitability I 352 Pancreatitis 1352 Peptic ulcer I 352 Primary I 350 Secondary I 350, 352, 592

Acidosis 1353 Bone 1352 Chronic nephritis I 352 Congenital malformation 1352 Hypocalcemia 1353 Osteoclasts I 352 Phosphorus I 353

Thrombosis 1352 Uremic osteodystrophy 1352 Von Recklinghausen's disease 1352

XIII

- Wasserhelle cell hyperplasia 1350 Hyperplasia II 898 Hypersarcosinemia 1231 Hypersensitivity II 836, 837 - Antigens II 837

Antigen-antibody complexes II 836 Cell-mediated II 837 Haptenes II 837 Macrophage inhibitory factor II 837

Hypersensitivity angiitis II 879 Hypertrophy II 898 Hyperuricemia 1218 - Heredity 1218 - Primary 1218 - Secondary 1218 Hypertension 1326, 352, 478, 493 Hypoadrenocorticism, Pituitary I 433 Hypocalcemia 1357 Hypoglycemia I 526; II 1096 - Alcohol I 527

Classification I 525 Clinicopathological correlation I 526 Gluconeogenesis I 527 In fetus I 527 In newborns I 527 Leucine I 527 5-methoxyindole-2-carboxylic acid 1527 Nonpancreatic tumors I 526 Pancreatic tumors I 526 Propranolol I 527 Quinaldinic acid I 527

Hypogonadism, Pituitary 1433 Hypoparathyroidism 1354 - Cataracts 1354

Chvostek's sign I 354 Convulsion I 354 Erb's sign I 354 Renal clearance I 354 Serum calcium 1354 Teeth 1354 Tetany 1354 Trousseau's sign 1354

Hypophysis I 425 Anterior lobe 1425 Basophilic cells I 425 Cancer 1964 Chromophobe cells I 425 Eosinophilic cells I 425 Organogenesis I 425 Pars intermedia 1425 Pars nervosa I 425 Pars tuberalis I 425 Pathology 1438 Posterior lobe I 434 - Oxytocin I 434 - Vasopressin 1434

Hypopituitarism I 432 Frohlich's syndrome 1432

- Idiopathic I 433 - Laurence-Moon-Biedl syndrome 1432 - Simmonds' cachexia I 432 Hypothalamic nuclei 1435 Hypothyroidism I 456

Anemia 1457 Carotenemia I 457 Cholesterol levels I 457 Cretinism I 456 Facies 1457 Fatty acid metabolism 1457 Hexose monophosphate shunt I 457 Mucopolysaccharide infiltration 1457 Mucopolysaccharides 1457 Myxedema 1456 Skin 1457 Steroid hormones I 457

XIV

Hypoxanthine guanine phospho ribosyl transferase I 224

Hypoxemia I 375 Hypoxia I 551

Imidazolone propionate hydrolase - Histidinemia I 179 Iminoglycinuria I 232 Immunity

Cellular II 820 Graft-versus-host reponse II 828 Hemangioblasts II 825 Lymphatic system II 820 Lymphocytes II 820, 825 Macrophages II 825, 827 Plasmoblasts II 825 T and B cell interactions II 828 Tolerance II 830

Capping II 832 Fetus II 830 High-zone II 832 Low-zone II 832

Immunodeficiency disease II 850,851,852 - Agammaglobulinemia II 853 - Third and fourth pharyngeal pouch syn-

drome II 853 Immunological disease II 854

Allergens II 854 Allergy II 854 Atopic II 854 Atopic eczema II 858

Benzylpenicillin II 855 Bronchial asthma II 856 Contact dermatitis II 858 Hereditary angioneurotic edema

11858 Pollen II 855

- Reagins II 854 - Rhinitis 11855 - Urticaria II 857 Glomerulonephritis II 860 - Antigen-antibody complex II 860 - Anti-basal membrane, II 860 Immune reaction to drugs II 859

Acetophenetidin II 859 Aminosalicylic acid II 859 Aspirin II 859 Hydantoin II 859 Methyldopa II 859 Quinidine II 859

Immunological enhancement II 1102 Immunological response to bacteria II 848 - Receptors II 849 Immunological response II 848

Parasi tes II 848 Tuberculosis II 848 Viruses II 848 Urticaria pigmentosa 11858 - Choriomeningitis virus II 849

Immunosuppression II 840 Immunosurveillance II 1103 Inborn errors of metabolism

Amino acid I 172 Albinism I 178

- Arginase I 233 - Argininuria I 233 Aromatic amino acid I 172 - Alkaptonuria I 177 - Phenylketonuria I 172 - Tyrosinosis I 177 Carbohydrate metabolism I 163

Drug induced hemolytic anemia I 170

Fructosuria I 169 Galactosemia I 167

- - - Hereditary hemolytic anemia 1231

- - - Therapy I 232 Inclusion bodies II 663, 1002

Bilirubin II 663 Ferrugination II 663 Hematin II 663 Lafora bodies II 663 Lewy bodies II 663 Negri bodies II 1003 Rabies II 1003

Indomethacin I 224 Infancy I 250

Glucose-6-phosphatase I 250 Iron 1250 Phenylalanine hydroxylase 1250 Protein intake I 250 Tyrosine transaminase I 250 Tryptophan pyrrolase 1251

Infantile Amaurotic Familia Idiocy (see Tay-Sachs-Disease) 1184

Inflammation Abscess II 795 Acute II 791 Angioneurotic edema II 774 Appendicitis II 793 Axon reflex II 766 Bacteriostatic agents II 788 Bradykinogen II 773 Capillary dilation II 766 Capillary permeability 11767, 771

Bradykinin II 771 Cement II 767 Exudine II 771 GF II 771 Kaleidin 11771 Leukotaxine II 771 Plasmin II 771 Pores II 768

Casea tion II 797 Catarrhal II 792 Cellular changes . II 778 - Leukocytic migration II 778 Chemical mediators II 768 - Histamine II 768 Chemotaxis II 779 Defective leukocytic response II 791 Diapedesis II 779 Eosinophils II 788, 789 Epitheloid cells II 796 Fibrinous II 792 Fibrosis II 795 Giant cells II 796 Granulomas II 795 Granulation tissue II 765 Gross appearance II 792 Hemorrhagic II 792 Hemorrhage II 765 5-Hydroxytryptamine II 771 Kallidin II 773 Kallikreins II 773 Leprosy II 799 Lymphocytes II 789 Macrophages II 789 Necrosis 11765, 795 Phagocytosis II 782 Plasmocytes II 789 Phlegmon II 795 PMN migration II 765 Process as a whole II 765 Prostaglandin 11775 Purulent II 792 Pus formation 11765 Pustules II 793 Repair II 765 Serous II 792

Subject Index

Syphilis II 797 Tuberculosis II 796 Vascular reaction 11766 Vasodilation II 765

Initiation Factors I 130 MzA 1130 MzB 1130 M3 1130 R 1130 S 1130 TR 1130

Initiation of translation - Eukaryotes I 129 Initiator II 987

Factors I 129 - - Fl 1129 - - Fz 1129 Inosine I 110 Insulin 1283, 495, 530

Adenylate cyclase I 521 Antibodies I 502 Binding I 520 - Adipose tissue I 521 Binding - Diaphragm I 521 Deficiency I 502 Diabetes and glucagon I 506 Effect on adipose tissue I 519 - Glycerokinase 1519 - Lipogenesis 1519 Glutathione-insulin transhydrogenase 1502 Guanylate cyclase I 521 Insulinase I 502 Metabolic effect I 510

Liver 1512 Muscle 1510 - Glycogen synthesis I 511 - Oxidation of pyruvate 1511

Mode of action ATP synthesis 1518 Carrier I 516 Effect on adipose tissue I 519 Gluconeogenesis I 513 Glucose-6-phosphatase I 513 Glucose output 1513

Mode of action (con'd) Glycogen synthesis I 513 Hexokinase theory 1516 Protein synthesis 1518 - Transcription 1519 - Translation 1519 Transport theory I 515

Receptors 1521, 528 Secretion I 506 - Islets of Langerhans I 506 - Regulation I 520 Sinalbumin I 502 Structure I 508 Transport 1510

Interferon Inducers II 1007 - Polyanionic macromolecules II 1007 Ind uction II 1006 Picronavirus II 1007 RNA-dependent RNA polymerase II 1006 Thymidine kinase II 1006

Intermediates in oxidative phosphoryla-tion 147

Interphase I 87 Intestinal, bypass I 599 - Bypass I 599 Intestinal flora I 323 Intestinal polyps II 948

Subject Index

~ DNA contents I94 Intestinal secretion I 262

Aminopeptidase I 262 Amylase I 262 Enterokinase I 262 Exopeptidase I 262 Invertase I 262 Lactase I 262 Lipase I 262 Maltase I 262

Intestine, Irradiation I 607 Intracellular Distribution I7

Fatty acids I 57 ~ Glucuronic pathway I 25 ~ Krebs Cycle I 31 ~ Pentose pathway I25 Intrinsic factor I 286

Antibodies I 287 ~ Assay I 287 ~ Gastrectomy I 286 Invertase I 503 Iodide Oxidation I 440 Iodinated tyrosine I 440 Iodine I439

metabolism I 440 ~ Thiocyanate I 440 Oxidation I 439 Pump I 439 Release I 439 Storage I 439 Trapping I 439

Ionizing radiation II 733, 746 Biological effects II 733 Effect on gastrointestinal tract II 736 Effect on gonads II 735 Effect on hematopoietic organs II 735 Effect on mammary glands II 735 Effect on ovaries II 735 Effect on skin II 733 Types of exposure II 733

Iron II 1009 Absorption I363 Atom I 377 Catalase I 379 Cytochromes I 378 Deficiency I 383, 384

Dysphagia I 383 Incidence I 363 Pathogenesis I 385 Plummer-Vinson syndrome I 383

Ferrochetalase I 206 Heme I 206 Hemoproteins I 378 Incorporation in red cells I 371 ~ Kinetics I 371 Metabolism I 363, 375

Chlorosis I 363 Control I 373 Hemolytic anemia I375 Hypoxemia I375

Orbitals 1378 Release I 364 Requirement 1363 Role in hematopoietic system I 366 Secretion I 365 Tissue distribution I 365 Transport, Intestinal I 363 Uptake in red cells I 371 Xanthine oxidase I 364

Irridation II 701, 1099 ~ Beer-Lambert law II 721 ~ Ionization II 720 Isobutyryl CoA I 58 ~ Pathway I 58 Isocitric dehydrogenase 130 Isolated hepatocytes II 1056

Isoleucine, Maple syrup disease I 181 Isopentenyl pyrophophate II 694 Isotope 182 ~ Uptake I82 Isovaleric CoA I 58 ~ Pathway I 58

Jaundice I 389 Bilirubin I 385 ~ Diglucuronide I 389 ~ Monoglucuronide I 389 Blood brain barrier I 389 Drug induced hemolytic anemia I 170 Gilbert's disease I 393 Hemolytic pathogenesis I 393 Hepatic I 392 Kernicterus I 389, 390 Neonatal I 389 ~ UDPGA transferase I 389 Nonhemolytic 1389

Congenital familial 1390 ~ Enzymes I 391 ~ Glucuronyl transferase I 390 ~ Kernicterus I 391 Pathogenesis I 394

Obstructive I 392 Pathogenesis I 389

J-chain II 819 Juxtaglomerular apparatus I 557

Blood volume I 557 Erythropoietin I 557 Lace cells I 557 Renin 1557

Kallidin II 773 Karyolysis 1610 Karyorrhexis II 611 Karyotype I 234 ~ Giemsa banding I 235 Kaschin-Beck disease 1379 Keratinization I 307 Keratinosulfates II 935 Keratosulfate II 934 Kernicterus I 389, 390 Ketoacyl thiolase I 57 B-Ketoacyl-ACP-Reductase I62 a-Ketoglutarate decarboxylase 130, 270 Ketosis I 55, 58

Acetoacetic acid I 522 Acetoacetyl CoA deacylase I 522 P-hydroxybutyric acid I 522 Diabetes I 522 Gluconeogenesis I 525 Malnutrition I 253 ~ Mechanism I 523

Kidney I539 Amino acid excretion I 546 Anatomy I 539 Arteriolae rectae I 540 Glucose reabsorption I 545 Gout 1546 Hemoglobin reabsorption I 546 Hypernephroma II 1100 Lithiasis I 546 Mutarotase I 545 Phlorhizin I 545 Renal artery I 540 Renal glucosuria I 545 Renal tubles I 540 Sodium reabsorption I 553 Transplant II 839 Uric acid reabsorption 1545

Kinins in disease II 774 Anaphylactic shock II 774 Angioneurotic edema II 774 Carcinoid II 774

Carcinoma of lung II 774 Carcinoma of thyroid II 774 Flushing II 774

XV

Retroperitoneal neuroblastoma II 774 Krabbe's disease I 196, 197 ~ Brain 1197 Krebs cycle I 27, 1030

Aconitase 129 Citric Acid synthesis 128 Distribution in tissues 131 Fate of Succinyl-CoA 128 Fumarase I 30

Isocitric dehydrogenase I 30 a-Ketoglutarate decarboxylase I 30 Lipoic acid I 30 Pyruvate metabolism 131 Succinic dehydrogenase I 30 Thiamine pyrophosphate I 30 Three-point attachment theory 128

Kuru II 1009 Kwashiorkor 1262

Anemia 1264 Brain I 264 Edema 1265 Essential amino acids I 265 Fatty liver I 264 Glucose I 265 Mental retardation I 264 Pancreas I 265 Pathogenesis 1263, 266 Pathology 1263 Potassium I 262, 265 Protein I 262 Protein turnover I 265 Water retention 1265

Kynurenase I 272 Kynurenic acid I 274 Kynurenine formamidase 1272 Kynurenine-3-hydroxylase 1272 Kynurenine transaminase I 273

Lactases I 503 Lactase intolerance I 231 Lactic dehydrogenase, ~ Fetus 1249 ~ Nucleus 180 Lactonase I 21, 25 Lafora bodies II 663 Laurence-moon-biedl syndrome I 432, 433 Lectins I 521 Leiomyoma II 963 ~ Estrogen II 963 Lens 1514 Leprosy, ~ Lepromatous cell II 799 Lesch-Nyhan syndrome 1216, 224 ~ Dopamine-p-hydroxylase I 225 ~ Hypoxanthine guanine phosphoribosyl

transferase I 224 Leucine in maple syrup disease I 181 Leukemia II 743, 1100

Viruses II 1012 Bregen-Moloney virus II 1012 Erythroleukemia II 1013 Friend virus II 1013 Graffi virus Il1012 Gross virus II 10 12 Horizontal transfer II 1012 Lymphatic leukemia II 1013 Moloney virus II 1012 Myeloid leukemia Il1013 Rauscher virus II 10 13 Schwartz virus II 1012 Thymus II 1013 Vertical transmission II 1012 X-irradiation II 1012

XVI

Leukocytic migration II 778 - Leukocytic margination II 778 - Membranes II 778 - Stickiness II 778 Leukocyte movement II 1095 Leukodystrophies I 196

Globoid lipoidosis I 196 Krabbe's Disease I 196 Metachromatic I 197 Sulfa tides I 196 Sulfatase I 196 Sulfa tide synthetase I 196

Lewy bodies II 663 L-glyceric aciduria I 232 Ligands I 376 Linoleic acid II 639 Linolenic acid II 639 Lipemia 1271 Lipemic Retinitis II 711 Lipids Blood II 689

Cerebrosides II 685 Cholesterol II 689 Cholesterol esters II 689 Diabetes II 690 Esterified fatty acids II 689 Neutral fats II 689 Nonesterified fatty acids II 689 Phospholipids II 689 Principal sources II 690 IX-triglycerides II 689 p-triglycerides II 689 Origin II 690

ApoC II 690 Chylomicrons II 690, 691 Fatty acids II 691 HDL II 690 LDL II 690 Protein lipase II 691 Triglycerides II 691 VLDL II 690

Lipogenesis I 519 Lipoic acid I 283 - Fat infiltration I 26 Lipoic Dehydrogenase I 26 Lipoidosis I 184 - Metachromatic leukodystrophy

I 197 - Tay-Sachs disease I 184 Lipoprotein,

Blood II 687 - Apoproteins II 688 - Cholesterol II 688 - Density-gradient centrifugation II 687

Flotation II 687 Low-density II 687 Micellar II 687 Mobility II 688 Pseudomolecular II 687 Sf value II 687 Solubility II 688 Very high-density II 687 Very low-density II 687

Lipoprotein lipase II 686 Liposarcomas II 1026, 1100 Lithiasis I 302, 546, 592 - Renal calculi I 593 Liver Disease 1277, 278

Endoplasmic reticulum I 587 Hepatic artery I 585 Hepatic cells I 585 Hepatic lobule I 585 Kiernan's spaces I 585 Kupffer's cells I 585 Microbodies I 587

Proteases I 587 Steroid hormones 1494 Protein turnover I 586 - Arginase I 586 - Starvation I 586

Liver regeneration II 1063 Liver steatosis II 635

Alcohol II 642 Carbon tetrachloride intoxication II 638 Cardiac insufficiency II 640 Diabetes II 640 Endoplasmic reticulum II 637 Ethionine II 640 Galactosemia II 640 Lipophanerosis II 637 Liposomes II 636 Microscopy II 635 Mitochondria II 637 Phosphorus II 640 Puromycin II 640 Starvation II 640 Triton X-IOO II 637 Ultrastructure II 635

. LSH, 1487 Lung, 1577

Alveolar wall, I 577 Cancer, II 993, 1100 Fetus, 1577 Function, - Gas exchange, I 576, 577 Passive congestion, I 577 Pneumonia, I 577 Septae, I 577

Lupus erythematosus, II 871 Afferent limb theory, II 872, 875 Am antigen, II 873 DNA antibodies, II 872 Efferent limb theory, II 875 Endocarditis of Libman-Sacks, II 873 Forbidden clones, II 872 Natural history, II 871 Onion skin arteriolar sclerosis, II 873 Vasculitis, II 873

Lymphangioma II 948 Lymphocytes II 821

B cells, II 823 - Bursa, II 823 Life span II 821 Lymphokinins, II 829 Null cells, II 826 Proliferation, II 918 - DNA synthesis, II 918 - Histones, II 919 Recircula tion, II 821 T cells, II 822 - Thymus, II 823

Lymphocytes B, II 824 - Factors, II 829 - Histones, I 91 - Interaction with T cells, II 825 Lymphokinins, II 829

Blastogenic factors, II 830 Growth inhibitory factor, II 830 Migration inhibitory factor, II 829 Mitogenic factor, II 830 Transfer factor, II 829

Lymphotoxic factors, II 829 Lyon's hypothesis, 1491 Lysine oxidase, II 933 Lysogeny, II 1008 Lysosomal disease, I 199 Lysosomes, 1316,620,653

Enzymes, II 627 A form, II 627

- B form, II 627

Subject Index

- Physiological role, II 621 - Pinocytic theory, II 621

Macroglobulinemia, Waldenstrom's dis-ease, II 882, 883

Macrophage inhibitory factor, II 837 Macrophage movement, II 1095 Macrophages, II 789, 827

Phagocytosis, II 790 - Acid hydro lases, II 790 - Electron transport, II 790 - Respiratory activity, II 790 Promonocyte, II 790

Malaria, I 149 Malaria in drug induced hemolytic ane-

mia, 1170 Malate aspartate shuttle, II 644 Malate citrate shuttle, II 644 Malatonin, I 106 Male sex hormones, leydig cells, I 483 Malnutrition, 1159

Body size, I 252 Diabetes, I 247 Fetus, 1248 General, 1247 Glucose alanine cycle, I 253 Growing child, I 252 Growth retardation, 1252 Ketosis, I 253 Lactation, 1247 Osteoporosis, I 253 Placenta, I 247 Pregnancy, 1247 Protein deficiency, I 253 Steroid hormones, I 248

Malnutrition in disease, 1318 - Disaccharidases, I 318 - Dumping syndrome, 1318 - Steatorrhea, I 318 Malonyl CoA-ACP transacylase, I 62 Maltases, I 503 Mammary cancer, II 1096 Mammary tumors, B particles, II 1014 Maple syrup disease, I 57

Alloisoleucine, I 181 Branched amino acids, I 181 Decarboxylase, I 181 Isoleucine, I 181 Leucine, I 181 Pyridoxal phosphate, I 181 Transaminase, 1181 Valine, I 181

Maple syrup urine disease, I 179 Marchiafava-Micheli syndrome, 1381 - Transferrin, 1381 - Transferrinemia, 1381 Marfan's syndrome, II 934 Mast cells, II 769, 770 McArdle's disease (see glycogen storage

disease), I 166 Megaloblast, DNA content, I 94 Megaloblastic anemia, orotic aciduria,

1229 Meiosis, I 489

Chiasmata, I 489 Chromatids, 1489 Crossover, I 489 Pachytene, I 489 Zygotene, I 489

Melanin in albinism, I 178 Melanin in phenylketonuria, I 174 Melanocyte in albinism, I 178 Melanocyte-stimulating hormones, 1472 Melanoma, II 1100 Membranes, I 542, 550 - Nuclear, 173

Subject Index

Mental retardation, I 264 Messenger RNA, II 1021, 1060 - Binding to ribosomes, I 126 - Polycistronic, I 133 Metabolic acidosis, I 580 Metachromatic leukodystrophy, 1197 - Brain, I 198 - Pathogenesis, 1198 Metaphase, 187 Metastasis, II 1089 - Liver, II 951 Methemoglobinemia, I ISS

Benzoquinoacetic acid, I 157 Compensatory polycythemia, I 155 Cyanosis, I 155 Diaphorase, 1156 Hemoglobin M, 1156 Methemoglobin reductase, I 155 NADPH-dependent methemoglobin re­ductase, I 156

Methotrexate, 1297 Methoxytyramine in phenylketonuria,

1174 Methylcholanthrene, II 987 p-methylcrotonyl CoA carboxylase, I 279 - Mode of action, I 280 Methylglutaconase, I 57 I-methylhistidine, 1160 3-methylhistidine, I 160 2-methylhydronaphthoquinone, I 36 Methylmalonate CoA-isomerase, 159 Methylmalonic aciduria, 1232 Methyl purine, I 110 Mevalonic acid, II 693, 694 Mevalonic kinase, II 694 M factor, I 119 Michaelis-Menten theory, I 503 Microbodies, I 137, 587

D amino oxidase, I 137 Half life, I 137

- Isocitrate dehydrogenase, I 137 - L-hydroxy acid oxidase, I 137 - Nucleoids, I 137 Microglia, II 664 Microsomes, 1316 Microtubules, I 105 Milk, II 1014 - B particles, II 10 14 - Composition, 1251 Mineralization, I 339

Alkaline phosphatase, 1340 Fluorine, I 340 Helmholtz double layer, I 338 Sodium, I 340 Strontium, I 340 Surface ions, I 338

Minimal deviation, II 1030 Mitochondria, I 55, 60, 316; II 646, 1033,

1048 DNA, 166 Gene expression, I 67 Ribosomes, I 67 RNA, 167 RNA polymerase, 167 Transfer RNA, I 67

Mitochondrial DNA, II 1032 Mitochondrion, I 45, 63

Cardiolipin, I 65 Chloramphenicol, I 66 Cris tae, I 63 Membranes, I 65 Movements, I 65 Origin, 165 Particles, I 45 - Antimycin, I 46

Mitomycin, II 615

Mitosis, I 87 Anaphase, 187 Aster, 187 Centromere, I 87 Centrosome, I 87 Interphase, I 87 Nuclear membrane, I 87 Nucleoli, 187 Prophase, I 87 Spindle, I 87 Telophase, I 87 X-radiation, I 87

Mitotic apparatus, I 105 And colchicine, I 106 And griseofulvin, I 106 And melatonin, I 106 And podophyllotoxin, I 106 And UV light, I 106 And vinblastine, I 106

Mixed-function oxidase, I 60; II 640, 643, 975

- Benzoflavone, II 976 - Cigarette smoking, II 976

Indole-3-acetonitrite, II 976 - Induction, II 975 - Nicotine, II 976 - Parathion, II 976 Polycyclic hydrocarbons, glutathione trans-

ferase, II 976 Mixed-lymphocyte culture, II 848 Molecular orbital, I 376 Moloney virus, II 1012 Molybdenum, I 161 Mongoloid facies and thalassemia, I 157 Monotyrosine, deiodination, 1442 Mosaicism, 1489, 491 Mucopolysaccharide, 35S-incorporation,

1284 Mucopolysaccharidosis, 1241; II 938

Corrective factors, II 939 p-galactosidase, II 939 Hunter's syndrome, II 938 Hurler's syndrome, II 938 Sanfilippo syndrome, II 938 Syndrome S, II 938

Multiple sclerosis, II 669 Astrocytosis, II 670 Autoimmunity, II 671 Charcot's triad, II 669 Demyelinization, II 670 Geography, II 669 Gliosis, II 670 Intention tremor, II 669 Lead, II 669 Measle viruses, II 672 Microglial infiltration, II 670 Nystagmus, II 669 Parasthesia, II 671 Pathology, II 670 Plaque, II 670 Scrapie, II 672 Slurred speech, II 669 Spastic paraplegia, II 671 Thrombi, II 671 Transient blindness, II 671 Virus, II 669, 672

Muscular dystrophy, I 569; II 672 Muscular injuries, 1315 Mushroom toxins, II 654 - Amanita muscaria, II 654 - Amanita phalloides, II 654

Amanitine, II 654 Muscarine II 654 Phallin, II 654 Phalloidine, II 654 RNA polymerase, II 654

Mutagens, I 94 Mutation, II 990 - Carcinogenesis, II 990 - Operator 0 mutants, I 131 - Polarity, I 131, 133 Mutarotase, I 545 Myasthenia gravis, II 824 Myelin, II 665

Birefringent, II 665 Histochemistry, II 666 Lipid, II 666 Protein, II 666

XVII

- Amino acid sequence, II 667 Proteolipids, II 667 Schmidt-Lanterman clefts, 11665 Schwann cell, II 665 X-ray diffraction, II 665

Myelination, II 667, 668 - Charcot-marie-tooth disease, II 668 Myeloma,

Clasmatosis, II 883 Flame cell, II 884

- Multiple, II 883 - Russell's bodies, II 884 - Thesaurocytes, II 884 Myeloperoxidase, deficiency, II 788 Myocardial disease, II 649 Myocardial infarct, II 697, 701, 705 - Electrocardiographic findings, II 707 - Norepinephrine, II 707 Myoglobin, 1152 - Heme, 1153 - Structure, I 152 Myopathy, II 649 Myxedema, I 433, 456; II 700 - Primary, 1456 - Secondary, I 456

NADase, 134 NADH coenzyme Q reductase, 143 NADH/NAD ratio, II 644 NAD metabolism, 1275 NAD synthetase, 1274 NADP-L-hexonate dehydrogenase, 125 Naphthalene, drug induced hemolytic ane-

mia, 1170 Natriuretic hormone, I 560, 561 Necrocytosis, dynamic changes, II 611 Necrosis, I 608

Coagulation, I 608 Fat 1609 Liquefaction I 608 Microscopic I 609 Type 1608

Negri bodies II 1003 Neonatal jaundice I 389 - Placental barrier I 390 - UDPG dehydrogenase 1389 Neo-oncogene II 1104 Nephrolithiasis 1351, 352 Nephrosis II 700 Nernst equation I 568 Nernst potential I 569 Nerolidol pyrophosphate, II 695 Nerve cells, II 661

Acetylcholine, II 662 Astrocytes, II 663 Axon flow, II 662 Betz cells, II 661 Cylindraxile, II 661 Dendrite, II 661 Inclusion bodies, II 663 Injury, nissl substance, II 662 Neurofibril injury, II 662 Neurofibrillar structure, II 661 Nissl substance, II 661

XVIII

Nervous fibers, II 664 Axon, II 664 Axoplasm, II 664 Clefts of Schmidt-Lanterman, II 664 Fibers of Remak, II 664 Myelin, II 665 Nodes of Ranvier, 11664 Schwann cell, II 664

Nervous system, II 661 Neuroblastoma, II 1100 Neurofibril, II 661

Densification, II 662 - Disintegration, II 662 - Fibrolysis, II 662 - Swelling, II 662 Neurofisin, I 436 Neurons, purine metabolism, 1216 Neurophysins, I 437 N 10-formyltetrahydrofolic acid, 1294 Niacin, I 271 Niacinogen, I 271 Nicotinic acid, 1272, 414

Deficiency, I 271 - Cholesterol, 1271 - Lipemia, 1271 Metabolism, 1271, 272

Deamido NAD, I 274 NAD synthetase, I 274 Niacin, 1271 Niacinogen, I 271 Tryptophan, I 274 Xanthurenic acid, I 272

Ribonucleotide, I 273 Tryptophan metabolism I 272

Niemann-Pick disease I 193 Behinic acid I 195 Brain I 194 Liver 1194 Pathogenesis I 196 Sphingomyelin I 195 Spingomyelinase I 196 Spleen 1194

Nissl substance II 661 - Chromatolysis II 662 - Densification II 662 Nitrogen balance 1478 Node of Ranvier II 664, 666 Nodules of Minet II 869 Nonenzymic transanimation, Schiff base

1300 Nontropical sprue - Celiac disease I 324 - Gliadin I 324 Norepinephrine in phenylketonuria 1174 Nuclear inclusion II 1003 Nuclear injuries, viruses II 1001 Nuclear membrane - And endoplasmic reticulum 175 - Annuli 174 - Permeability I 74 Nuclear transplantation II 1061 Nucleic acid 188 Nuclein 188 Nucleolus 175, 120

Chromosomes· . I 7~ Liver regeneration I 77 Regenerating liver I 78 Ribosomal RNA I 79 Starvation I 77, 78 Thioacetamide I 78 Ultraviolet light I 77 X-irradiation (nucleolus) 177

Nucleophilic reagent I 50 Nucleoside diphosphokinase 131 Nucleotide 124 Nucleotide pyrophosphatase I 34

Nucleus Adenosine triphosphatase I 83 5'-adenylic phosphatase 183 Aldolase 180 Arginase I 84 Cytochrome oxidase I 84 DNA content 193 DNA polymerase I 83 Enzymes 183 Glycolysis I 80 Hexokinase I 80 Hydrolytic enzymes I 83 Ionizing radiation I 81 Lactic dehydrogenase I 80 Membrane, pores I 73 Oxidative phosphorylation I 81 Protein synthesis I 82 Sources of energy I 80 Triose phosphate dehydrogenase I 80 Urea-forming system 184

Nutrition, infancy 1250

Obesity I 325, 326 Atherosclerosis I 326 Glucagon I 326 Glucoreceptors I 326 Hunger 1326 Hypertension I 326 Ketogenesis I 327 Metabolic regulation 1326 Psychological factors I 327 Satiety center I 326

Ocre mutation I 118 Odontoblasts I 279 Okazaki fragments I 102 Oligodendrocytes II 663 - Satellitosis II 664 - Sensitivity 11664 Oligomycin I 50, 52 One gene-one enzyme theory in drug indu­

ced hemolytic anemia 1171 Operator genes I 130 Operon theory I 130

Histidine I 130 - Lactose I 130 - Polarity I 131 Opsin 1306 Optical isomerism I 56 Orotic aciduria I 225, 228 - Aspartic transcarbamylase I 229 - Megaloblastic anemia I 229 - Ureidosuccinic acid 1229 Ossification 1334

Cancellous bone I 335 Compact bone I 335 Havers canal I 335 Osteoblast 1334 Osteoclast I 335 Osteocyte I 334

Osmotic pressure I 540 Anoxia 1542

- Membrane I 542 - Selective solvation I 542 Osteoblasts I 279, 334 Osteoclast I 335 Osteogenesis imperfecta II 933 Osteogenic sarcoma II 1100 Osteoid I 279 Osteoporosis 1355, 358, 478

Aged 1356 Calcium/PO ration I 355 Immobilization 1356 Pathogenesis I 355 Schmorl's nodules I 356

Oxalic acid metabolism I 183 Oxaluria I 182, 594

Subject Index

2,3-diketo-L-gulonic acid I 182 Glyoxylic acid I 182 Glyoxylic acid dehydrogenase I 182 N-glyoxylglutamic acid I 182 Lithiasis I 182 Oxalic acid metabolism I 183

IX-Oxidation I 59 fJ-Oxidation pathway of fatty acids I 54,

55 w-Oxidation I 59 Oxidative phosphorylation I 46

Alcohol dehydrogenase I 49 Amy tal 147, 50, 52 ATP-ADP exchange reaction 152 ATPase release I 52 ATP_32p; exchange 152 Azide 152 Chemiosmotic coupling I 53 Chlorpromazine I 52 Conformational coupling I 53 Coupling factor I 51 Coupling mechanisms 147 Cyanide 147 H2 180-ATP exchange reaction 152 H2 180-Pi exchange reaction 152 Intermediates 147,48 Oligomycin I 50, 52 Sites of phosphorylation 147 Uncoupling agents I 47

Oxythiamine I 267

Palmitaldehyde dehydrogenase I 55 Pancreas cancer II 1100 Pancreas regeneration II 1063 Pancreatic secretion I 261

Cholecystokinin I 262 Hormones I 262 Pancreozymin I 262 Secretinase I 262 Secretin I 262

Pancreatitis 1352; 11630, 711 Amylase II 632 Chronic II 631 Fatty necrosis II 631 Hypocalcemia II 632 Lipase II 632 Pancreozymin I 532 Pathogenesis II 632 Secretin II 632 Trypsin II 632 Trypsinogen II 631

Pancreozymin I 262 Pantothenic acid deficiency I 275

Diabetes I 277 Hypercholesterolemia I 277 Coenzyme A I 276 Congenital anomalies I 276 Duodenal ulcer I 276 Liver disease 1277, 278 Renal deficiency I 277

Papillomas II 1026 Paraaminoazobenzene II 977 Paraglobulinemia II 881 Paramonomethylaminoazo-benzene II 977 Parathormone I 346

Aconitase I 348 Adenylcyclase I 349 Amino acid sequence I 347 Bone resorption I 348 Citric acid I 348 Collagenolytic effect I 349 Condensing enzyme I 348 Control of secretion I 347 Cyclic AMP I 349 DNA metabolism I 349 Effect 1348

Subject Index

Effect on bone I 348 Glomerular filtration of phosphate 1349 Isocitric dehydrogenase I 348 Lacta te I 348 Mitochondrial I 349 Phosphaturic action 1349 Protein synthesis I 349 Purification I 347 RNA metabolism I 349

Parathyroid, cancer II 1100 Parathyroid glands, oxyphilic cells I 346 Partial hepatectomy, histones I 91 Partial pressures of CO 2 I 580 Passive congestion I 577 Pasteur effects II 1028, 1029, 1043

ADP II 1043 - Inorganic phosphate II 1043 - NADH II 1044 - Phosphofructokinase II 1044 Pathogenesis of nontropical sprue I 324 Pathogenesis of vitamin C deficiency I 285 Pathological calcification I 358 - Microincineration 1358 - Von Kossa staining 1358 Pellagra 1271

Black tongue I 271 Clinicopathology 1271 Dementia 1271 Dermatitis 1271 Diarrhea I 271 Nicotinic acid 1271 Pathogenesis I 274

Penicillin G II 994 Pentose pathway 121 - Intracellular distribution I 25 - Transaldolase I 22 Pentose phosphate pathway I 21

Distribution I 24 Glucose-6-phosphate dehydrogenase 121 Goal in metabolism I 22 Metabolic sequence I 23 Phosphogluconate dehydrogenase 121

Pentosuria I 24, 232 Pepsin 1256 - Inhibitor 1257 - Phosphoserine I 257 Pepsinogen 1256 Peptic ulcer I 352 Peptide bonds, polyglycine 1151 Peptide bond synthesis I 126 Peptidyl transferase I 127 Periodic paralysis I 564 Periodic table I 375 Pernicious anemia I 284, 289

Anisocytosis I 289 Bone marrow I 289 Demyelination 1289 Gastric smears I 289 Hematological changes 1289 Heredity I 288 Megaloblast I 289 Nucleated red cells I 289 Neurological degeneration 1289 Normoblast 1289 Pathogenesis 1293 Polymorphonuclears I 289 Thrombocytes I 289 Tongue 1289 Vitamin BI2 1286

Peroxisomes (see Microbodies) I 137; II 643

- Petroleum products II 994 pH 1571 - Acidosis 1571

Alkalosis I 571 Bicarbonate absorption I 573 Blood 1571 Carbonic anhydrase I 573 Cell 1572

A Phage II 1008 Phagocytin II 788 - Deficiency II 788 Phagocytosis I 24; II 782, 1000

Choline II 784 Ehrlich ascites cells II 788 Glucose II 784 Glycogen II 785 Glycolysis II 785 Histamine II 784 Macrophages II 790 Membrane II 784 Opsonin II 783 Opsonization II 784 Phospholipids II 785 Phagosome II 784 Polymorphonuclear II 786 Respiration II 785 Salt II 784

Phenylalanine hydroxylase infancy I 250 Phenylbutazone I 224 Phenylketonuria 1108, 172

Ascorbic acid I 174, 175 Biosynthesis of melanin 1174 Carcinoids I 174 Copper 1175 Dihydropteridine I 172 3,4-dihydroxyphenylalanine I 174 Dopa decarboxylase I 174 Epinine I 174 Fetalliver I 175 Glutamic acid decarboxylase I 176 Hydroxy tryptophan decarboxylase I 176 Metabolic alterations I 175 Methoxytyramine I 174 M-tyramine I 174 Neurological lesions I 176 Norepinephrine I 174 Pathogenesis I 175, 177 Pathogenesis of neurological lesions I 176 Phenylalanine hydroxylase I 172 Phenyltryptamine I 176 Pyridoxal phosphate I 174 S-adenosylmethionine transferase I 174 Serotonin I 174 Tetrahydropteridine I 172 Tyrosinase I 174 Tyrosine transaminase I 174

Pheochromocytomas II 964, 1096 Phlorhizin I 545 Phorbol II 987 Phosphocarboxykinase II 1046 Phosphodiesterase I 529 Phosphoenolpyruvate kinase 131 Phosphoenolpyruvic carboxykinase II 1042 Phosphofructokinase I 531 ; II 1043, 1046 - Fetus 1249 Phosphoglucomutase I 170 - Galactosemia I 168 6-Phosphogluconate dehydrogenase 121 Phosphoprotein phosphatase 1531 Phospho ribosyl pyrophosphate I 211 Phosphorylase 1301; II 1049

Conversion from active to inactive 1166 Fetus 1249 Nucleus 183

Photochemistry II 723 - Free radical II 723

- Nucleic acid II 723 Photosensitivity I 206 Pionolactone II 994 Picolinic acid I 273

XIX

Pigmentation in Gaucher's disease 1191 Placen ta I 247

Glutamic dehydrogenase I 248 - 17-B-hydroxysteroid dehydrogenase

1248 - Steroid hormones 1248 Placental barrier I 390 Plasma proteins I 158

Inborn errors Actalasia I 159

- Agammaglobulinemia I 159 - Wilson's disease 1159

Plasmin 1413-414 Plasminogen 1414 Platelets

Agglutination I 411 Aggregation 1410 Collagen 1410, 411 Enzyme 1409 Histamine I 409 Megakaryocytes I 409 Romanofsky staining I 409 Serotonin I 409 Thromboplastin 1401 Thrombosthenin 1410

Plummer-Vinson syndrome I 383 Podophyllotoxin I 106 Polyarteritis nodosa II 878 - Prodromic factor II 878 Polycythemia I 373 Polyglycine I 151 Polyhedroses II 1003 Polyoma virus II 1013 Polyp II 951 Polymorphonuclear II 786 - Granules II 786 - - Streptolysin A II 787 Polypeptide bonds I 149 - Hormones, Extended 1510 Polypeptide chains I 123 - Elaboration I 123 Poly ribosomes I 123, 135; II 1064 Polyuria in galactosemia I 167 Polyunsaturated fatty acids II 639 Pompe's disease I 199 Pores 173 Porphobilinogen 1202, 203 Porphyria I 200

Acquired 1209 b-amino levulinic acid synthetase I 209 Coproporphyrins I 209 Cutanea tarda I 209 Erythropoietica I 206 Fluorocytes I 206 Heme 1209 Hepatica 1207-209

Alcohol I 208 b-amino levulinic synthetase 1208 Barbiturates I 208 Ergot preparation I 208 Sulfonal I 208

Hexachlorobenzene 1209 Isomerase I 207 Photosensitivity 1206 Ultaviolet light 1209 Uroporphyrins 1209

Porphyrinogens, Conversions I 205 Porphyrins 137, 200, 201, 373

b-amino levulinic acid I 203 - Dehydrogenase I 203 - Synthetase I 203 Biosynthesis I 202

xx

Porphyrins, Chemistry 1200-201 Copper porphyrin I 201 Heme 1205 Porphobilinogen 1202 Pyridoxal I 203 Side chain 1201 Succinate-glycine cycle I 203 Uroporphyrins 1201 - Biosynthesis 1204

Portocaval transposition in glycogen sto­rage disease I 165

Posttranscriptional regulation I 1052 Potassium I 567

Acidosis I 567 Alkalosis I 567 Body fluids I 567 Carbonic anhydrase I 567 Donnan's law I 568 Cellular metabolism 1569

Acetyl kinase I 569 Fructose-I,6-diphosphate I 569 Fructose-I-phosphate I 569 Hyperkalemia I 569 Pyruvic kinase 1569

Membrane I 567 Metabolism I 567 Nernst equation I 568 Structural water I 567

Prausnitz-Kustner reaction II 834 Prematurity 1250 Primaquine, Drug induced hemolytic ane-

mia 1171 Progesterone I 247 - Cancer II 962 - Ovaries I 480 Proinsulin covalent structure I 509 Proline I 284 - Hydroxylase I 284; II 934 Promonocyte I 790 Promotor II 987 PRPP synthetase I 211 Prophage 111008 Prophase I 87 Propionic acid I 59 - Metabolism I 59 Propionyl CoA carboxylase I 278 Propylactone 11994 Prostaglandin 11775, 833

A3 II 775 E1 II 775 E3 II 775 Biosynthesis II 776 Function II 777

Aspirin II 777, 778 Carcinoma of thyroid II 777 Cholera II 777 Electrolyte transport II 777 Fertility II 777 Hyperemia II 777 Hypertension II 778 Inflammation II 777 Menstrual fluid II 777 Parturition II 777 Synaptic transmission II 777 Transport of water 11777

Metabolism 11775 Degradation II 777 Hormones II 776 Lung 11776 Phospholipase II 775 Prostaglandin dehydrogenase 11775 Prostaglandin reductase I 775 Prostaglandin synthetase II 775 Synthesis II 775

Structure II 776

Protamines I 88 Protein deficiency I 253

Amino acid imbalance I 254 - Menstruation 1254 - Nitrogen balance 1253 Protein digestion I 255

a-amylase I 255 Carboxypeptidase I 256 Chymotrypsin I 256 Elastase I 256 Gastric juice I 255 Kallikrein I 255 Lysozyme I 255 Pepsin 1256 Salivary glands I 255 Trypsin I 256 Zymogens I 256

Proteins I 149 Amino acids I 151 - Sequence I 149 Configura tion I 151

Cysteine I 151 Histidine I 151 Proline I 151 Serine I lSI

Hydrogen bonds I 152 Inborn errors I 158 Kinase 1531 Metabolism, Liver I 585 Peptide bonds I 151 Polypeptide bonds I 149 Sparing effect of carbohydrates I 589 Structure I 149 Synthesis I 106, 124; II 1009

Amino acid activation I 107 Amino acyl RNA synthetase I 108 Fetus 1250 In vitro I 107 In vivo I 106 Mitochondria I 449 Nucleus 182 Phenylketonuria I 108

Tertiary structure I 152 Turnover I 265

Prothrombin, Deficiency® 1401 - Vitamin K I 408 Proton transfer I 550 Protoporphyrin breakdown I 386 Provirus II 1021 Proximal tubule I 594 Pseudohermaphroditism 1491 Pseudohypoparathyroidism I 354 Pseudouridine I 110 Psi factor I 119 Pulmonary acidosis 1581

Emphysema I 581 Pleuritis I 581 Pneumonia I 581 Pulmonary edema 1581

Pulmonary emphysema II 648 Pulmonary fibrosis II 648 Punctation codons 1118 Purine biosynthesis 1212, 213

Control II 1052 - Amidophosphoribosyltransferase II 1052 - PRPP II 1052 Inborn errors of metabolism I 209

Purine metabolism 1210 Adenosinic kinase 1216 Adenylosuccinase 1214 AMP pyrophosphorylase 1215 5-amino-4-imidazole N-succinocarbox­amide ribotide I 213 5-amino-4-imidazole carboxamide ribo­tide 1213

Subject Index

N 5, N 1 °anhydroformyltetrahydrofolic acid 1212 Azaserine [212,214 Deaminase I 217 Formylglycinamide ribotide 212 5-formamido-4-imidazole carboxamide ribotide I 213 N 1°-for-myltetrahydrofolic acid 1213 Guanase 1217 Glutamine I 211 Glycinamide ribonucleotide synthetase 1212 Glycinamide ribotide 1212 GTP 1214 Isonicase I 213 Nucleoside Hydrolases 1217 Nucleoside phosphorylase 1215, 217 Nucleotidases 1216 5'-nucleotidase 1216 Nucleotide interconversion 1215 Origin of various atoms of purine ring 1214 Phosphatases 1216 Phospho ribosyl pyrophosphate 1211 PRPP synthetase I 211 Purine nucleotide after conversion 1214 Ribosylamine pyrophosphorylase 1211 Salvage pathway 1216 Transferases I 216 Xanthine oxidase I 217 Xanthosine-5-phosphate I 214

Pygmies I 433 Pyknosis 1610, 612 Pyridine nUcleotides I 33 Pyridoxal I 297 - Phosphate 160 - Maple syrup disease 1181 - Phenylketonuria I 174 Pyridoxamine I 297 Pyrimidine I 225

Cytosine I 225 5-hydroxymethylcytosine I 225 Inborn errors of metabolism 1209 5-methylcytosine I 225 Pseudouracil I 225 Thymine I 225 Uracil 1225 Biosynthesis I 227

Pyrimidine metabolism I 225 Aspartic acid synthetase I 226 Azauracil I 226 Carbamyl phosphate I 226 Control II 1052 - Carbamyl phosphate II 1052 - UTP II 1052 Cytosine deaminases I 228 Dehydropyrimidine dehydrogenase 1228 6-diazo-50xo-L-norleucine 1227 Dihydroorotic acid dehydrogenase 1226 Dihydrothymine hydrolase I 228 Dihydrouracil hydrolase I 228 Hypoxanthine guanine phospho ribosyl transferase 1216 5' -nucleotidases I 228 Orotidylic pyrophosphorylase I 226 5' -orotidylic acid I 226 Orotidine-5'-phosphate decarboxylase 1226 Phospha tases I 228 Phosphodiesterases I 228 Phospho ribosyl pyrophosphate I 226 Phosphotransferases I 228

Subject Index

- Thymidylate synthetase I 227 - Ureidoisobutyric acid I 228 - Ureidopropionic acid 1228 Pyridoxine I 297

Amino acid decarboxylation I 300 Cow's milk I 298 Cystathione I 30 I D-amino oxidation 1301 D-amino acid racemization I 301 Dehydrases I 301 Deoxypyridoxine I 297 Diamine oxidase 1301 Glutamic aspartic transaminase 1300 Heme synthesis I 302 Homoserine dehydrase I 301 Phosphorylase I 301 Pyridoxamine phosphate 1297 4-pyridoxic acid I 297 Pyridoxine phosphate oxidase 1297 Schiff base I 299 Serine hydroxymethyl transferase I 302 Transamination 1299 Urocanase 1301 Vitamin B6 I 297

Pyridoxine deficiency I 298 Arteriosclerosis I 298 Clinicopathological correlations I 298 Convulsions I 298 Dental caries 1298 Lithiasis I 298, 302 Magnesium I 298

Pyrithiamine I 267 Pyruvate decarboxylase 1270 Pyruvate metabolism 131 - Nucleoside diphosphokinase 131 - Phosphoenolpyruvate kinase 131 Pyruvemia I 269 Pyruvic acid I 269 Pyruvic acid decarboxylation I 26, 27 Pyruvic carboxylase II 1042, 1046, 1047 Pyruvic decarboxylase I 269 Pyruvic kinase II 1042, 1046, 1047

Quinolinic acid I 272, 273 Quinolinic-2-carboxylic acid 1272

Rabies II 997, 1005 Radiation I 391

Biochemical effects II 746 Acetic acid biosynthesis II 748 CO 2 elimination II 748 Cytoplasmic radiosensitivity II 746 DNA II 746 Enzymes II 746

Amino acid oxidase II 746 ATPase II 747 Ca talase II 746 Carboxypeptidase II 746 Chymotrypsinogen II 747 DNase II 746 Hexokinase II 747 Hydrolases II 747 Phosphoglyceraldehyde dehydro-

genase II 747 Polyphenol oxidase II 746 Ribonuclease II 747 Succinoxidase II 747 Trypsin II 747

Fructose-I,6-diphosphate II 748 Nuclear radiosensitivity II 746 Oxygen consumption II 748

Biological effect II 733 Delayed necrosis II 737 Duodenum II 737 Enzymes II 746

Jejunum II 737 Lung II 737 Nephritis II 737 Parotid II 737 Stomach II 737

Cancer II 742 Cause of death II 737 Effect on antibody formation II 751 Effect on cell population kinetics II 752 Effects on DNA synthesis II 749, 751 Effect on DNA synthesis, Regenerating liver II 749 Effect on mitosis II 751 Effects on ribosomes II 750 Leukemia II 743, 745, 746

Radiation carcinogenesis II 742 - Xeroderma pigmentosum II 742 Rauscher virus II 1013 Receptors 1288, 437, 488, 527, 528, 531,

533, 560; II 1061, 1066, 1080 Acetylcholine I 528 Clustering II 1079 Dexamethasone I 528 Epinephrine I 528 Glucagon I 528 Insulin I 528 Virus II 1000

Red cells I 566, 608 Aging II 619 Embden-Meyerhof pathway 1369 Enucleation I 608 Fate 1370 Glutathione I 369 Glutathione reductase I 369 Hemoglobin I 369 Hexose monophosphate shunt I 369 Sodium leakage I 566 Spherocytosis II 619 Stromatin 1369

Red cells life span, Drug induced hemolytic anemia I 148, 171

Refsum disease I 59 Regenerating liver II 898 - Chalone II 916 - Nucleolus I 78 Regeneration II 895

Adrenal II 920 Blood vessels II 920 Bone marrow II 920 Gonads II 920 Intestinal mucosa II 920 Kidney II 916 - DNA synthesis II 917 - Mitosis II 917 Lens II 897 Limb II 896 Miscellaneous II 920 Pancreas II 917

Amylase II 917 DNA synthesis II 917 E thionine II 917 Methionine II 918 Pancreatectomy II 918 Zymogen granules II 918

Skin II 920 Spleen II 920 Tail II 895 Liver II 898

Amino acid content II 900 Cephalin synthesis II 899 Cofactors II 914 Deoxyribonucleotides origin II 905 DNA synthesis II 907 - Regulation II 911

XXI

Enzyme activities II 901 Fatty acid synthesis II 899 Glycogen metabolism II 899 Hypertrophy II 908 Hypophysectomy II 914 Lecithin synthesis II 899 Lipid content II 899 Mitochondria II 899 Mitosis II 914 Nucleotide pools II 904 - Orotidylic pyrophosphorylase

II 904 - UMP kinase II 904 Ornithine II 914 Ornithine decarboxylase II 913 Plasma protein II 900 Polyamines II 913 Protein synthesis II 899 Putrescine II 913 Regulation of gene expression

II 908 RNA synthesis II 901, 902 - Regulation II 910 Spermidine II 913 Triggering II 914 Urea cycle II 914 Urea formation II 900

Regulator genes I 130 Releasing factor I 488, 533 Releasing hormones I 455 - LRF, CRF, GRF, PRF, MRF 1455 Renal calculi I 594

Cysteinuria I 594 Gout I 593, 594 Hyperparathyroidism I 594 Oxaluria I 594 Phosphatic calculosis I 595 Proximal tubule I 594 Silicon I 595 Tams protein I 595 Urinary protein 1594 Uromucoids 1595 Vitamin A I 594

Renin I 256, 557 Renin-angiotensin system I 558 Renin-angiotensin I I 558 Renin-angiotensin II I 558 Repressor I 132 Respiratory center I 578

Expiration I 578 Inspiration I 578 Pneumotaxic center I 578 Receptor I 579 - Chemorecepter I 579 - Pressure receptor I 579 - Stretch receptor I 579

Respiratorychain 132 Actimycin I 43 Coenzyme Q I 43 Cytochrome c I 43 NADH coenzyme Q reductase 143 Pyridine nucleotides I 33 Succinic coenzyme Q reductase I 43 Ubiquinone I 42 Vitamin E I 42 Vitamin K I 42

Respiratory quotient I 33 Retina 1309 Retinene i I 311 Retinoblastoma II 1100 Retinol, All trans 1305 Reverse transcriptase II 1021 Reye's syndrome II 654

Mitochondria II 654 Ornithine-transcarbamylase deficiency II 654

XXII

Reye's syndrome, Viruses 1654 Rh System II 843

Anti-C antibody II 843 Anti-E antibody II 843 D antigen II 843 Fisher-Race theory II 843 Weiner's theory II 844

Rheumatic fever II 866 Rheumatic heart disease II 866

Angina pectoris II 869 Aortic stenosis II 868 Aschoff body II 869 Hypostatic pneumonia II 868 Mitral stenosis II 867 Nodules of Minet II 869 Verruca II 867

Rheumatoid arthritis II 875 Amyloidosis II 877 Clinical symptoms II 876 Granulation tissue II 877 Incidence II 876 Lysosomes II 878 Membrane II 878 Pathogenesis II 876 Pathology II 877 Rheumatoid factor II 876 Subcutaneous nodules II 877

Rhodopsin II 1076 - Vision 1312 Riboflavin I 35, 302

A therosclerosis I 303 Bums 1302 Deficiency I 303 - Cheilitis I 303 - Glossitis I 303 Formula I 303 Glycogen synthesis I 302 Requirements I 302

Ribosomal RNA, Nucleolus 179 Ribosomes I 123

Proteins I 126 - - Acetylation I 125 - - Phosphorylation I 125 - RNA 1125 Ribosome binding I 126

EF-T factor I 127 EF-T, factor I 127 EF-T u factor I 127 Messenger RNA I 127 Transfer RNA I 126

Ribosome in mitochondria I 67 Ribosylamine pyrophosphorylase I 211 Ribulose-5-phosphate I 21 Rickets 1341, 345

Calcium resorption in bone I 345 - Intestinal absorption of calcium I 345 - Reabsorption of phosphate in kidney

1345 Rifampicin I 102 Rifampin II 615 dsRNA 1121 RNA methylases 1114 - S-adenosly methionine I 114 - Tumors I 115 RNA polymerase I 118; II 1020

CAP factor I 119 Initiation I 119 Y factor I 119 M factor I 119 Mammalian I 119 - IX-amanitin 1120 - Nucleolar 1120 Mitochondria I 67 Mitochondrial RNA I 449 Nucleoplasmic I 120 T factor I 119

- T4 phage 1119 - Units 1119 RNA release, Regenerating liver II 1041 RNA replicase II 1020 RNA synthetase II 1020 RNA transfer I 122 - Nuclear membrane I 122 - Nuclear pores 1122 Rods 1310 Rous sarcoma II 1016 - Virus II 1011

Saccharase I 503 Saccharase intolerance 1231 S-Adenosyl Methionine I 114 S-Adenosylmethionine Transferase in Phe-

nylketonuria I 174 Salivary Gland - DNA synthesis II 919 - Proliferation II 919 Salmonellosis and Sickle Cell Anemia

1149 Salvage pathway II 1037 Sanfilippo syndrome II 938 S antigen II 1022 Scarla tinal toxin II 1009 Sarcoidosis, Schaumann's bodies II 880 Satellite DNA 179 Satiety center I 326 Schiff base I 300 Schwann cell II 664, 665 Schwartz virus II 10 12 Scurvy II 279

Abscesses I 282 Adrenals I 282 Amino acid Concentration I 283 Cataracts I 284 Clinicopathology 1279 Collagen 1279, 281 Dentin 1279 Endochondral Ossification I 279 Fibroblasts I 279 Glucose tolerance I 283 Glucuronic pathway I 282 17-Hydroxycorticosteroid 1283 Hydroxyphenylpyruvic hydroxylase 1283 Insulin I 283 Lipoic acid I 283 Mucopolysaccharide 1284 Odontoblasts 1279 Os teo blasts I 279 Osteoid I 279 Proline hydroxylase I 284 Stress 1282 Subperiosteal hemorrhage 1281 Trummerfeld zone 1281 Wound healing 1281 X-irradiation 1283

Seborrheic dermatitis 1278 Secretinase I 262 Secretin I 262 Selenium I 317 Serine hydroxymethyl transferase I 302 Serotonin II 833 Serotonin in Phenylketonuria I 174 Serum calcium 1354 Sex chromatin I 241 Sex chromosomes I 85, 489

Anomalies I 490 Amenorrhea I 490 Deletion I 490 Ring X 1490 Sterility 1490

Lyon's hypothesis 1491

Subject Index

Sex glands - Hereditary disease I 489 - - Klinefelter's syndrome I 489 - - Turner's syndrome I 490 Sex hormones 1479

Breast 1482 Cervical gland I 482 Effect of hypophysis I 486 Effect of male sex hormones I 482 Feedback regulation 1487 Fertilization I 482 Hypophysis FSH I 486 Hypophysis ICSH I 487 Hypophysis LSH I 486 Menstrual cycle I 481 Placen ta I 482 Receptor I 488 Stein-Levanthal syndrome 1494 Vaginal epithelium 1482

Shope papilloma II 1017 Shope papilloma virus II 1011 - Carcinogens II 1011 - Hormones II 1011 Sialic acid biosynthesis I 189 Sialic acid synthesis I 185 Sialyl transferase II 1080 Sickle cell anemia I 145

Aspirin I 155 Balanced polymorphism I 149 Bone marrow pathology I 149 Cyanate I 154 Malaria 1149 Pathogenesis I 148 Pathology I 147 Radiological Picture I 149 Red cell life span I 148 Salmonellosis I 149 Urea 1154

Sickle cell trait I 149 Siderosis 1379

Cytosiderosis I 379 Kashin-Beck disease 1379 Lungs 1379 Nerves 1379

Sigma unit I 119 Simmonds' cachexia 1432 Sinalbumin I 502 Sites of phosphorylation 147 Skin cancer II 950 Slow virus diseases II 1009

Aleutian mink disease II 1009 - Creutzfeldt-lakob disease II 1009 - Heredity II 1009 - Kuru II 1009 Smallpox II 1005 Smegma cancer II 962 Smoking II 700 Smooth endoplasmic reticulum II 647 snRNA 1121 Sodium II 1064 Sodium balance I 555 Sodium inhibition of initiation I 129 Sodium leakage, glycolysis I 566 Sodium leakage, red cells I 566 Sodium load I 560 Sodium losses I 560 Sodium metabolism I 551

Sodium chloride I 551 Sodium pool I 551 Sodium potassium dependent ATPase 1552 Sodium pump I 551

Sodium potassium ATPase II 1967 Sodium potassium dependent/ATPase

1552 - Membranes I 552

Subject Index

Sodium pump 1551 - Hypoxia I 551 Sodium reabsorption I 553

Carbonic anhydrase I 554 - Congestive heart failure I 554 - Regulation I 554 - - Aldosterone 1554 Somatomedin A 1429 Somatostasin 1429 Spherocytosis II 619 Sphingolipids metabolism 1199 Spindle II 1064 Spingosine biosynthesis I 186 Splenomegaly in thalassemia 1157 Sprue I 320, 322

Crypts of lieberkuht I 322 Gliadin I 323 Idiopathic steatorrhea I 322 Intestinal flora I 323

Squalene conversion II 695, 696 - Squalene oxidocyclase II 696 Squalene formation II 695

Famesoate II 694 Famesyl pyrophosphate II 694 48--47 Isomerases II 696 Isopentenyl pyrophosphate II 694 Mevalonic kinase II 694 Nerolidol pyrophosphate II 695

Squamous cell carcinoma II 1100 Staphylococcal toxin II 1009 S tarva tion I 77, 252 Steatorrhea 1319,343 - Cystic fibrosis I 320 - Sprue 1320 Steatosis II 647 - Alcoholism II 647 Stein-Leventhal syndrome 1494

Amenorrhea I 494 Block of 3-p-oldehydrogenase I 494 Flushes I 494 Hirsutism 1 494 Obesity 1 494 Polycystic ovary I 494

Steroid hormone biosynthesis 1460 ACTH 1461 Adrenodixin reductase I 463 Aldosterone I 465 Androstendione I 463 Cholesterol I 460 Conversion of cholesterol to pregeno­lone 1461 Desmolase 1463 17-estradioldehydrogenase 1465 Estrogen I 465 Formation of cortisol 1462 Formation of progresterone 1462 20-hydroxycholesterol I 460 22-hydroxycholesterol 1460 II-hydroxylase I 463 Isomerase I 463 Pathway for estrogen 1466 Pathway for testosterone 1465 Pregnanediol I 460 Sex hormone synthesis 1464 Sex hormone testosterone I 465

Steroids 121, 24 Steroid hormone inactivation 1466

Aryl sulfate 1466 Cirrhosis I 466 Conjugation 1466 Dehydrogenase 1 467 Glucuronidase I 466 Glucuronides I 466 Hydroxysteroid dehydrogenase 1467 Hypothyroidism I 466 4-reductase 1466

- Reductases 1467 Steroid hormones 1 494

Amino acid uptake I 483 Aryl sulfatase 1466 Glucose-6-phosphate dehydrogenase 1483 Glutamic dehydrogenase 1483 Hormone gene theory I 485 Liver disease 1494 Mechanisms of action I 483 Protein biosynthesis 1484 Receptors 1 486 RNA synthesis 1485 Transhydrogenase I 483 Uptake of cx-aminoisobutyric acid 1483

Steroid metabolism I 531 Stillbirth I 250 Stomach cancer II 1100 Streptococcal toxin II 1009 Stress 1282 Stretch receptor I 556 Stromatin I 369 Structural genes I 130 Structured water II 725 Succinate-glycine cycle I 203 Succinic coenzyme Q reductase I 43 Succinic dehydrogenase 1 30, 36 Sucrase I 503 Sugar absorption I 504

Carrier I 504 - Energy I 504 - Sodium I 504 Sulfanilamide drug induced hemolytic anemia

1 170 Sulfatase I 196 Sulfatides I 196 Sulfa tide synthetase 1 196 Sulfating factor I 431 Sulfonal 1 208 Sympatheticoblastomas II 1096 Syphilis II 797 - Gumma II 797 Syndrome S II 938 Syringomyelia II 672

T Factor 1 119 Taka-diastase 1 34 T antigen II 1022 Tangier disease II 711 Tay-Sachs disease I 184

Brain I 186, 187, 188 Gangliosides 1 185 Hexosaminidase I 190 Pathogenesis I 190 Retina I 184

T cells II 822 Antigen recognition II 825

- Helper substance II 826 - Receptor II 825 - Rosette formation II 826 Telophase 1 87 Teratomas II 954 Termination codons I 118 12-0-tetradecanoyl-phorbol-13-acetate

II 987 Thalassemia 1 157

Anemia 1157 Bone marrow hyperplasia 1 157 Hair on end 1 157 Heme 1158 Hemosiderosis I 157 Heinz bodies I 158 Hepatomegaly 1157 Mongoloid facies I 157 Spenomegaly 1 157 Vicarious liver erythropoiesis I 157

XXIII

Throphylline I 210 Thiamine hydroxyethylthiamine I 269 Thiamine pyrophosphate 122 Thiamine pyrophosphokinase I 268 Thioacetamide I 78 Thiokinase 1 54, 55 Thiouracil I 441 Thiouridine 1110 Thrombi 1415,416,671

Platelets 1416 - Postmortem 1417 - Red 1417 Thrombin 1401, 403 Thromblastin component deficiency

1407 Thromblastin deficiency christmas dis-

ease 1407 Thrombocytopenia 1412 Thrombosis I 352 Thrombocytopenic purpura 1412 - Neonatal 1413 Thromboplastin I 402 Thrombosthenin 1410 Thrombus 1415

Mural 1417 - Opthalmotonometry II 708 - Steps in formation 1418 - Vegetation 1417 Thymidine methylation I 227 - Aminopterin 1 227 Thymidylate synthetase I 227 Thymine dimers II 725 Thymopoietin II 824 Thymopoietin II II 824 Thymus II 824 - Products II 824 - Myasthenia gravis II 824 Thymus tumors II 1096 Thyroglobulin 1441 Thyroglobulin synthesis 1441 Thyroid disease I 439 Thyroid adenoma hyperthyroidism 1451 Thyroid cancer II 1100 Thyroid carcinoma 1 358 Thyroid hormone 1441, 444

Binding I 443 Effect on mitochondrial RNA 1449 Effect on protein synthesis in mitochon­dria 1449 Effect on RNA polymerase I 449 Liver disease 1 444 Metabolism 1 445 Respiratory and metabolic acidosis 1444

Thyroid hormone in blood I 443 Thyroid hormone metabolism I 442

Nicotinic acid I 446 - Riboflavin 1 446 - Thiamine I 446 - Vitamin A 1446 Thyroid pathology 1450

Heterotrope factor (HTF) I 453 Long acting thyroid stimulus (LATS) 1453 Short acting thyroid stimulus (SATS) 1453 Thyrotropin 1 453 TSH 1453

Thyroid hormone secretion control 1453

Thyroxine 1 306 - Crystallization I 444 - Free 1444 Thyroxine metabohsm I 442 Tissue graft II 838 - Allograft II 838

XXIV

Tissue graft, Autograft II 838 Histocompatibility genes II 839

- Isograft II 838 - Transplantation antigens II 839 - Xenograft II 838 Tobacco mosaic virus, amino acid code

1117 Tobacco mosaic virus, organization 11998 Tolbutamide I 508 Tophi 1219 Tower skull and sickle cell anemia I 149 Toyocamycin II 615 Transaminase in maple syrup disease 1181 Transamination, nonenzymic 1299 Transcription I 122 - Nucleoli I 122 Transfer factors II 1099 Transfer RNA binding to ribosomes I 126 Transfer RNA in mitochondria 1 67 Transferrin I 365, 381 Transferrinemia 1381 Transformation II 1023

Hybridization II 1024 Morphology II 1023 Partial transcription II 1023 Phenotypic changes II 1023 Reserve transcriptase II 1024 Viral genome II 1023

Transformation in vitro II 988 Transformylase activity I 129 Transhydrogenase 1 34; II 644 Transketolase 121, 270 Translation inhibitors 11616 Transmethylation I 589 Transplantation antigens II 839 TRH structure 1455 tRNA I 109; II 1061

Alanine RNA I 110 Configuration I 112 Dihydrouridine I 110 Inosine I 110 Methyl purines I 110 Pseudouridine I 110 Sequence I 110 Synthesis tRNA I 109

TSH secretion II 1096 TSTA antigen II 1022 Tricarboxylic acid I 26 - Pyruvic acid decarboxylation I 26 - Thiamine pyrophosphate 126 Triglycerides biosynthesis II 692 3,5',3' -Triiodothyronine 1444 Triphosphopyridine nucleotide (NADP)

133 Triose phosphate dehydrogenase nucleus

180 Trisomy I 489

X 1489 XX 1490 XXY 1489 XYY 1490

Tropocollagen II 926, 927 Tropoelastin II 929 Trousseau's sign I 354 Trummerfeld zone 1281 Trypsin I 256 Trypsinogen I 257 - Amino acid sequence I 258 Tryptophan 1 274 Tryptophan metabolism 1 272, 273

2-Acroleyl-3-amino-fumarate 1272 Catalase 1 272 Diabetes I 273 3-hydroxyanthranilic acid I 272, 274 3-hydroxyanthranilic oxidase 1272 Kynurenase I 272, 274

Kynurenine formamidase 1272 Kynurenine-3-hydroxylase I 272 Kynurenine transaminase I 273 Nicotinic acid I 272 Nicotinic ribonucleotide 1 273 Picolinic acid I 273 Quinolinic acid I 272, 273 Quinolonic-2-carboxylic acid 1272 Tryptophan pyrrolase I 272 Xanthurenic acid I 272

Traptophan pyrrolase I 272 TSH secretion 1 454, 455

Control hypothalamus I 454 - Control neurohormone (TRH) I 454 - Receptors I 454 - Releasing hormones I 455 Tuberculosis II 796

Caseation II 797 Macrophages II 848 Miliary II 798 Prostate II 799

Tumors II 947 Benign II 947 - Acquired 1 947 - Congenital II 947 Cystic II 947 Malignant II 947, 948 - Cytoplasmic abnormalities II 949 - Nuclear changes II 949

Tumor cells I 514 Tumors RNA methylase I 115 Turner's syndrome 1490

Amenorrhea I 490 Breast 1490 Gonadotropins I 490 Ovaries I 490 Sterility I 490

Turnover, endoplasmic reticulum I 587 - microbodies 1 587 - proteases I 587 M-tyramine in phenylketonuria I 174 Tyrosinase in albinism 1 179 - phenylketonuria I 174 Tyrosine aminotransferase II 1054 - transaminase, infancy I 250 - - phenylketonuria 1 174, 175 Tyrosinosis I 177

Ubiquinone I 42 UDP-glucuronide pyrophosphatase 124 UDP-transglucuronylase 124 Ulcerative colitis II 885 Ultraviolet light porphyria 1209 Ultraviolet radiation in albinism I 178 Unsaturated fatty acid I 185 Unwinding protein I 102 Urea 1226 Urea cycle 1589

Arginine synthetase I 590 Carbamyl phosphate synthetase 1590 Inborn errors I 588, 591 Ornithine carbamyl transferase I 590 Rate-limiting step I 590

Urea-forming system nucleus 184 Urea metabolism I 585 Urea synthesis I 589 Uremia 1591

Chronic renal disease 1 592 Erythropoietin I 591 Glucose tolerance 1591, 592 Pericarditis I 591 Secondary hyperparathyroidism I 592 Toxin 1591, 592

Urethane 11984 - N-hydroxy derivative II 984 Uric acid I 210

Subject Index

- Reabsorption I 545 Uric acid degradation I 211 Uric acid metabolism 1 217 - Uricase 1217 Uricase I 217 Uridine diphosphoglucose dehydrogenase

124 Urine formation 1542

Antidiuretic hormones I 545 Autoregulation of glomerular filtration 1543 Blood pressure I 543 Convoluted tubules I 544 Countercurrent exchanges I 545 Glomerular filtration I 543 Loop of Henle I 544

Urobilinogens I 388 - Enterohepatic cycle I 388 - Stercobilin I 388 Urocanase 1301 - Histidinemia I 179 Urocanic acid in histidinemia I 179 Uroporphyrinogen I 1204, 205 - Uroporphyrinogen III 1204, 205 Uroporphyrin I 1204 - Uroporphyrin III 1 204 Uterus II 962

Deciduomas II 963 - Endometrial moles II 963 - Polyps II 963 UV irradiation II 724

Base alteration II 724 Biological effects II 717, 724 Effect on skin II 726 Structured water II 725 Thymine dimers II 725

UV light 1 106

Vagina, cancer II 967 Valine in maple syrup disease I 181 Valinomycin II 1077 van den Bergh reaction I 387 - Direct I 387 - Indirect I 387 Vasopressin 1434

Acenyl cyclase I 437 Alteration in functional activity I 434 Amino acid sequence I 434 Cyclic AMP 1437 Microtubules I 437 Receptors 1437 Secretion I 435

Baroreceptors I 436 - Epinephrine I 436 - Prostaglandin E I 436 - Volume receptor 1436 Synthesis I 434

Vicarious liver erythropoiesis in thalasse­mia 1157

Vinblastine I 106 Viral replication II 10 19

Catabolism II 1022 Changes in cell membrane II 1022 Cyclic AMP II 1022 DNA synthesis II 1021 Enzyme induction· II 1021 Minus strand II 1020 Murine leukosis virus II 1021 Plus strand II 1020 Provirus II 1021 Reverse transcriptase II 1021 RNA polymerase II 1020 RNA replicase II 1020 RNA synthetase II 1020 RNA virus II 1019 S antigen II 1022

Subject Index

T antigen II 1022 TST A antigen II 1022 Vaccinia II 10 19 Viral messenger RNA II 1021

Viroids II 10 10 Viruses II 996

Affectiveness of RNA II 998 Bacteriophage II 997 Capsid II 999 Chemotherapy II 1005 ~ Halogenated pyrimidines II 1005 ~ N',N'-Anhydrobis (fi-hydroxyethyl) biguanide hydrochloride II 1005 ~ N-Methylisatin 3-thiosemicarba­zone II 1005 Cytoplasmic alterations I 1001 Hepatitis II 650 Inclusion, viral II 1002 ~ Cytomegalovirus II 1003 ~ Nuclear II 1003 ~ Polyhedroses II 1003 Inclusion bodies II 1002 ~ Councilman bodies II 1003 ~ Guarnieri's bodies II 1003 Injuries II 1000 Interferons II 1006 Lysogeny II 1008

Diptheria toxin II 1008 ~ Herpetic infection II 1008 ~ .Ie phage II 1008 ~ Prophage II 1008 Molecular biology II 997 Molluscum contagiosum II 1003 Morphopoietic factors II 1000 Morphopoietic genes II 1000 Myxoviruses II 998 Nuclear injuries II 1001 Phagocytosis II 1000 Polykaryocytosis II 1004 Properties II 998

DNA II 998 RNA II 998 Shapes II 998 Size II 998

Protein II 997 Rabies II 997 Receptors II 1000 RNA II 997 Rod shape II 998 Self-assembly II 999 ~ Of tobacco mosaic virus II 999 Spherical II 998 ~ Icosahedral II 999 ~ Octahedral II 999 Structural organization II 998 Temperate II 1007 Tetrahedral II 999 Tobacco mosaic II 997, 998 Toxins II 1007 ~ Diphtheria II 1007 Turnip yellow mosaic II 999 Ultrastructural changes II 1002 Vaccinia II 998 Vaccination II 1004 ~ Rabies II 1005 ~ Smallpox II 1005 Virulent II 1007

Viscous metamorphosis, Product I 1401 Viscous metamorphosis, Product II 1401 Vision, molecular events 1312 Vitamin A (CII-cis-Retinol) 1305

Carotene I 306 Geometric isomers I 304 Kupffer cells I 306 Opsin 1306 Retinol I 305

~ Retinol binding protein I 306 ~ Sources I 305 ~ Storage I 306 Vitamin A deficiency I 304

Aureomycin 1306 Bone growth I 307 Clinical pathological correlation I 307 Hemeralopia I 304 Hydrocephalus I 308 Keratinization 1307 Keratomalacia I 304 Nyctalopia I 307 Steatorrhea 1305 Thyroxine I 306 Xerophthalmia 1304, 307

Vitamin A metabolism I 308 Alcohol dehydrogenase I 311 Chondroitin sulfate I 308 Differentiation I 309 DNA synthesis I 309 Glycolysis I 308 Kera tiniza tion I 308 Lysosomes 1309 Mucous synthesis 1308 Protein synthesis I 309 Retina 1309 Retinene 1 1311 Rhodopsin 1312 Rods and cones I 310 Vision 1312

Vitamin BI 1266 ~ Alcoholism 1266 Vitamin B6 1297 Vitamin BI2 159,286

Absorption I 286 Acetate synthesis I 291 Aminomutases I 290 Cancer 1292 Cobamide 1289 Corrin ring I 290 Cyanocobalamin I 290 Dehydrase 1291 DNA synthesis 1292 Ethanolamine deaminase 1291 Intrinsic factor 1286 Megaloblast I 292 Methionine synthesis I 292 Methotrexate 1292 Methylaspartate 1290 Methyl transfer I 291 Methylitaconate 1290 Methylmalonic aciduria I 291 Methyimaionyi CoA I 290 Receptors I 288 Releasing factor I 288 Ribose to deoxyribose conversion 1291 RNA synthesis I 292 Thioredoxin 1291 Thymidylate synthetase I 292 Werner's theory 1286

Vitamin D 1341 Absorption 1343 Calciferol I 342 Calcium binding to protein I 344 Calcium sensitive ATPase I 344 Chemistry 1341 1,25-dihydroxycholecalciferol I 343 Ergosterol I 342 Esterification I 343 Formula 1342 Formula of calciferol 1341 25-Hydroxycholecalciferol 1343 Intestinal absorption of calcium 1343 Lumisterol I 342 Precalciferol I 342 Provitamin D 1342

~ Steatorrhea I 343 ~ Tachysterol I 342 Vitamin D metabolism 1343, 344 Vitamin deficiency I 266, 284

Ascorbic acid deficiency I 279 Beriberi I 266 Biotin deficiency I 278 Nicotinic acid 1271

XXV

Pantothenic acid deficiency 1276 Pellagra I 271 Scurvy 1279 Seborrheic dermatitis 1278 Thiamine deficiency I 266

Vitamin E I 42 Antioxidant 1316 Dimers 1315 Electron transport I 317 a-Ketopheronic acid 1315 Lysosomes 1316 Microsomes 1316 Mitochondria 1316 Organic degradation 1313 Organic synthesis 1314 Tocopherols, formulas 1313 a-Tocopherol hydroquinone conjugate I 315 a-Tocopheronolactone conjugate 1315 Trimers I 315

Vitamin E deficiency 1313 Ceroid accumulation 1315 Duodenal ulcers I 314 Muscular injury 1315 Pregnancy I 315 Spermatogenesis 1315 Zenker degeneration 1315

Vitamin E metabolism 1315 Coenzyme Q I 317

~ Creatine phosphokinase I 317 ~ Hydrolases I 317 ~ Selenium I 317 Vitamin K I 42, 408 ~ Drug induced hemolytic anemia I 170 Von Gierke's disease I 164, 199 Von Recklinghausen's disease 1352 Von Willebrand's disease 1406

Water metabolism I 546 Bound water I 549 Dehydration I 546 Edema 1546 Thirst 1546 Water reabsorption I 546

Water molecule I 547 ~ Debye units I 547

Dipole moment I 547 Flickering iceberg I 548 Hydrogen bond I 547 Ice crystals I 548 Polarity I 547 Water cage I 548 Water clusters I 548

Water retention 1265 Water structure I 547

Anesthetics I 550 Clathrate I 550 Collagen I 550 Membranes I 550 Proteins I 550 Proton transfer I 549, 550 Water molecule 1547

Watson-Crick model of DNA I 99 Weber-Fechner law 1311 Wegener's granulomatosis II 879 Werner's theory 1286 Wilm's tumor II 1100

XXVI

Wilson's disease 1159 Aciduria 1160 Alzheimer cells I 160 Amino aciduria I 163 Ceruloplasmin 1159, 160 Cirrhosis I 159, 160 Copper 1159 Hepatolenticular degeneration I 159 I-Methylhistidine I 160 3-Methylhistidine 1160 Pathogenesis I 162

Wound healing 1281; 11920 p-Aminopropionitrile II 937 Amphibians II 921 Ascorbic acid deficiency II 937 Biochemistry II 924, 937

Acid phosphatase II 937 Alkaline phosphatase II 937 Aminopeptidase II 937 Cell proliferation II 924 Collagen formation II 924 p-Glucuronidase II 937

Causes II 920 Epitheliomesenchymal interactions 11938 First intention II 921 Homeostasis II 921 Inflammation II 921

Low-protein diet II 937 Mammals II 922

Collagen II 923 - Tensile properties II 923 Contact inhibition II 922 Chalones II 922 Desmosomes II 922 Fibroblasts II 922 Fibrogenesis II 922 Mitosis II 922 Scar tissue II 923

Penicillin II 937 Purposes II 920 Second intention II 920 X-irradiation effects II 937

Xanthine 1210 Xanthine oxidase 1217 Xanthinuria 1217, 232 Xanthoma II 710 Xanthomatosis tube rosa II 711 Xanthurenic acid I 272, 274 X-irradiation I 283

Absorption II 717 Biological effects II 717 Carcinogenesis 111041 Compton effect II 718, 719 Cross-linking II 726

Subject Index

DNA repair II 756 Double-strand breaks 11756 Effect on chromosomes II 753 Effect on DNA in vitro II 753 Effect on DNA in vivo II 755 Effect on mitosis II 755 Excitation 11720 Free radicals 11753 G value II 723 Hydrated electron II 722 Photoelectric effects II 718 Radiation holes II 723 Radiolysis II 722 Repair, cycloheximide II 756 Single-strand breaks II 754, 755 - 3'hydroxyl 5' phosphoryl bond,

II 755 . Thomson effect II 718 Thymine products II 753 Thymine radio lysis II 754 Xeroderma pigmentosum II 756

X-Radiation, mitosis I 87 X-ray, nucleolus 179 X-ray carcinogenesis II 742

Zinc 1376 Zymogen granules I 52 Zymogens I 256

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