SUMMARY OF THE PROPOSED PROJECT - …environmentclearance.nic.in/writereaddata/FormB/TOR/Brief_Summary/... · SUMMARY OF THE PROPOSED PROJECT 1. File No. - 2 ... Installed capacity

1

SUMMARY OF THE PROPOSED PROJECT

1. File No. -

2. (a) Name & location details of the project.

M/s. ASB LABORATORIES PVT. LTD., Plot Nos: 171, 172, 173 & 174, survey no 103, Gadvanthi Village,Humnabad Industrial Area, Humnabad, Bidar District,Karnataka.

(b) Address of Project Proponent for correspondence.

ASB LABORATORIES PVT. LTD., Flot no 102,1st floor ,Elite Residency, Matha Bhuvaneswari,Hi Tech city Mainroad, Khanamet, Madhapur, Hyderabad-500 084.

3. Objective of the Project Establishment of Bulk Drugs and Intermediates manufacturing industry

4. Project details Establishment of Bulk Drugs and Intermediates manufacturing industry

5. Details of major products manufactured (along with by-products)

a) Installed capacity Sl. No.

Name of the Product Quantity (TPM)

Quantity (Kg/day)

1 Biperiden Hydrochloride 1.0 40.0

2 Carisoprodol 1.0 40.0

3 Cetirizine Di-Hydrochloride 5.0 200.0

4 Ciprofloxacin Hydrochloride 0.5 20.0

5 Citalopram HBr 0.1 4.0

6 Clopidogrel Bisulfate 2.0 80.0

7 Enrofloxacin Hydrochloride 0.5 20.0

8 Entacapone 0.5 20.0

9 Fexofenadine Hydrochloride 0.5 20.0

10 Fluconazole 0.5 20.0

11 Hydroxyzine Hydrochloride 0.5 20.0

12 Imatinib Mesylate 0.5 20.0

13 Itraconazole 0.5 20.0

14 Lamivudine 1.0 40.0

15 Lansoprazole 1.0 40.0

16 Levo Cetirizine 1.0 40.0

17 Losartan Potassium 2.0 80.0

18 Mebeverine Hydrochloride 0.5 20.0

19 Meclizine Hydrochloride 0.5 20.0

20 Omeprazole 1.0 40.0

21 Pantoprazole 3.0 120.0

22 Paracetamol 20.0 800.0

23 Pregabalin 3.0 120.0

24 Sertraline Hydrochloride 3.0 120.0

25 Telmisartan 2.0 80.0

26 Tramadol Hydrochloride 0.5 20.0

27 Zidovudine 0.5 20.0

28 Cefuroxime Axetil 1.0 40.0

29 Atorvastatin Calcium 0.5 20.0

53.6 TPM 2144 Kg/day

b) Production at present NA

c) Proposed capacity NA

6. Details of major raw materials (quantity/month).

Details appended as Annexure - 1

2

7. Status of Organization: Government/Semi Government/Public/Private

Private Limited Company

8. Investment (Rs) Rs 9.85 Crores

9. Total labor force 53 people

10. Nature of land (KIADB/ KSSIDC/Revenue /Others)

KIADB industrial area

11. Location and land use details of the area with schematic plan.

Topo map of the project area is submitted.

12. Details of water bodies around the proposed industry.

Gadvanthi Village Nala is at a distance of about 0.66 km towards North & West direction, Humnabad Lake at a distance of about 1.92 km towards South East direction.

13. Nature of soil Soil analysis report is submitted.

14. Distance (if within 50 km) to the nearest

National Park

Sanctuary

Heritage site

Monument

Reserve Forest

Protected Forest

Inter State boundary

None None None None None None None

15. Greenery plan within industrial premises including open area (area % of total area & species proposed).

6879.47 Sqm (34 %)

16. Details of source of water (rivers, lakes, ground, public supply)

KIADB public water supply scheme

17. Water balance Water balance chart is submitted.

a) Total water requirement 82.75 KLD

(i) Domestic 3.6 KLD

(ii) Gardening 6 KLD

(ii) Industrial

Process

Washing/Cleaning

Boiler feed

Cooling tower make-up water

Scrubber

R&D

73.15 24.65 KLD 2 KLD 15 KLD 30 KLD 1 0.5

b) Total wastewater generated 38.4 KLD

(i) Domestic sewage generated 2.4 KLD

(ii) Industrial (m3/day) 36 KLD

Process 29 KLD

3

Washing/Cleaning

Boiler blow-down

Cooling tower make-up water

Scrubber

R&D

2 KLD 2 KLD(Blowdown) 1.5 KLD (Bleed Off) 1 0.5

c) Effluent treatment proposal (a) Domestic Sewage is treated in Septic tank and soak pit.

(b) Industrial Industrial effluent is proposed to be treated in Effluent Treatment Plant with Multiple Effect Evaporator (MEE) followed by RO filtration for treatment, reuse and disposal.

d) Mode of disposal (pond/ river valley/ underground sewer/irrigation/ocean/ others (specify)

a. industrial effluent – Re-used for landscape development, cooling tower make-up water etc.

e) Total area allocated for disposal of wastewater.

NA as the treated wastewater is not disposed on land.

18. a) Details of air pollution sources Boiler & DG set

Processing emission

Griders/crusher

Boiler

Power generators

NA Nil SO2, NOx, SPM SO2, NOx, SPM

b) Details of control equipment Boiler, & DG set – stacks

19. a) Solid waste details (i) Domestic (ii) Industrial (iii) Hazardous

14 kg/day

S.No Description Quantity

1 Ash from Boiler 1.5 TPD

2 Solvent residue 0.3 TPD

3 Evaporation salts 0.65 TPD

4 Process residue 0.23 TPD

Carbon 71 kg/day

Catalyst 0.5 kg/day

Inorganic Residue 32.6 kg/day

5 ETP Sludge 22 Kg/day

6 Municipal Wastes 30 kg/day

7 Detoxified containers 750 nos/year

8 Waste oil 120 Ltrs/year

9 Used batteries 1 No/Year

4

(b) Solid waste disposal methods (i) Domestic (ii) Industrial (iii)hazardous waste)

The domestic wastes are segregated at source, collected in bins and composted. .-

S.No Description Quantity Remarks

1 Ash from Boiler

1.5 TPD Sold to Brick manufactures

2 Solvent residue

0.3 TPD Sent to TDSF/ Cement units

3 Evaporation salts

0.65 TPD Sent to TSDF

4 Process residue

0.23 TPD Sent to Cement units

Carbon 71 kg/day For incineration in boiler

Catalyst 0.5 kg/day Returned to manufacturers

Inorganic Residue

32.6 kg/day

Sent to TSDF/Cement units

5 ETP Sludge 22 Kg/day Sent to TSDF

6 Municipal Wastes

30 kg/day Municipal solid waste disposal/vermin compost bed

7 Detoxified containers

750 nos/year

Sold to authorized vendors

8 Waste oil 120 Ltrs/year

Sent to Authorized Recyclers

9 Used batteries

1 No/Year Sent to Authorized Recyclers

20. Ambient noise level

(A) Source of noise and vibrations DG set

(B) Noise and vibration control measures proposed

Acoustic enclosure is proposed

21. Power requirement indicating source of power supply

1. The total power requirement is 200 KVA which is to be obtained KPTCL through KIADB.

22. Documents submitted:

Environmental Management Plan Submitted

Project report Pre-feasibility Report is Submitted

Clearance of Pollution Control Board

Applied

Clearance approved on site Emergency Plan from the Chief Inspector of factories & Boilers

Submitted

Topographical map of the area Submitted

REIA Submitted

Social commitment plan Submitted

5

ANNEXURE -1 RAW MATERIALS REQUIREMENT

Table .1: - Raw materials requirement

Sl. No.

Product Raw materials Quantity required

kg/batch kg/month kg/annum

1 Biperiden Hydrochloride

Mono Cyclo Penta Diene

33 2,541 30492

Methanol 325 25025 300300

Acetonitrile 30 2310 27,720

1,4 - Dioxane 230 17710 212520

Methyl Magnesium Chloride

275 21175 254100

Di Iso Propyl Ether 850 65450 785400

Piperdine HCl 36 2772 33264

Para Formaldehyde 11 847 10164

Iso Propyl Alcahol 550 42350 508200

Caustic Soda flakes 5 385 4620

Phenyl Magnesium Chloride

180 13860 166320

Iso Propyl Alcahol .HCl (18%)

30 2310 27720

Acetone 30 2310 27720

Activated Carbon 3 231 2772

2 Carisoprodol 2, – Methyl - 2 - n – Propyl propane -1,3

- Diol

100 1000 12000

Toluene 1100 11000 132000

Di Methyl Carbonate

80 800 9600

Methanol 500 5000 60000

S.M.O Powder 40 400 4800

Mono Iso Propyl Amine

95 950 11400

Chloro Form 800 8000 96000

Chloro Form 800 360 4320

Water 800 8000 96000

3 Cetirizine Di-Hydrochloride

Para Chloro Benzophenone

50 5000 60000

Sodium Boro Hydride

3.5 350 4200

Toluene 1545 154500 1854000

Methanol 251 25100 301200

6

Water 2115 211500 2538000

HCl 321.5 32150 385800

Piperzine 60 6000 72000

Tertiory Butyl Ammonium

Bromide

1 100 1200

Caustic Soda Lye 20 2000 24000

Di Chloro Methane 520 52000 624000

2 – Chloro Ethanol 35 3500 42000

Tri Ethyl Amine 43 4300 51600

Di Methyl Form amide

170 17000 204000

KOH 25 2500 30000

Ethyl Acetate 840 84000 1008000

NaCl 7 700 8400

S.M.C.A 45 4500 54000

4 Ciprofloxacin Hydrochloride

Acetophenone 150 750 9000

Ethylene Dichloride 704 3520 42240

NaOH 47 235 2820


Di Methyl Sulphate 255 1275 15300

Di Methyl Formamide

325 1625 19500

Potassium Carbonate

10 50 600

DM Water 3970 19850 238200

Cyclo Propyl Amine 30 150 1800

Toluene 115 575 6900

Sodium Carbonate 100 500 6000

C.S.Lye 10 50 600

Hcl 100 500 6000

Acetic acid 7 35 420

Methanol 440 2200 26400

N-Butanol 138 690 8280

Piperzine 172 860 10320

E D T A 100 500 6000

Carbon 4 20 240

5

Citalopram HBr

Magnesium 28 56 672

THF 450 900 10800

PFBB 145 290 3480

DMPAC 120 240 2880

5-cynophthalide 50 100 1200

Toluene 410 820 9840

7


Water 318 636 7632

NH4Cl 45 90 1080

HBr 11 22 264

IPA 200 400 4800

Di Hydroxy 65 124 1488

H3PO4 167 334 4008

NH4OP 90 180 2160

6 Clopidogrel Bisulfate

2 – Chloro phenyl glycene

100 2000 24000

H2SO4 130 2600 31200

Toluene 1.95 39 468

Di Chloro methane 0.3 6 72

Liquid Ammonia 70.06 1401.2 16814.4

Na2SO4 55 1100 13200

DM Water 601.5 12030 144360

Methanol 1.97 39.4 472.8

Acetone 0.28 5.6 67.2

L(+)Tartaric acid 77 1540 18480

Thiophene - 2 - ethanol

100 2000 24000

P.T.S.C 165 3300 39600

NaOH 0.15 3 36

T.B.A.B 5.5 110 1320

Acetonitrile 0.15 3 36

KHCO3 177 3540 42480

HCl 0.05 7 12

Ethyl acetate 0.4 8 96

Formaldihyde 0.15 3 36

Ammonia 0.07 1.4 16.8

7 Enrofloxacin Hydrochloride

Q –Acid 25 500 6000

N –Ethyl Piperzine 15.5 310 3720

C.S.Lye 13 260 3120


Methanol 120 2400 28,800

n-Butanol 17 340 4080

8 Entacapone Chloroacetyl Chloride

60 540 6480

Toluene 1250 11250 135000

Diethyl amine 42 378 4536

Water 1550 13950 167400

DMF 122 1098 13176

NaCN 22 198 2376

8

3-Methoxy-4-Hydroxy

Benzaldhyde

100 900 10800

NitricAcid 800 7200 86400

3-methoxy-4-hydrxy 5-

Nitro benzaldehyde

90 810 9720

AlCl3 90 810 9720

E.D.C 450 4050 48600

HCl 480 480 5760

Piperdine 20 180 2160

Methanol 325 2925 35100

9 Fexofenadine Hydrochloride

Methyl – 4 – (4 – chloro – 1 –

oxobutyl)2,2-dimethyl phenyl

acetate

140 420 5040

Azocyclonal 100 300 3600

Toluene 750 2250 27,000

Potassium carbonate

40 120 1440

Methanol 120 360 4320

Water 530 1590 19080

Sodium Boro Hydride

9 27 324

Sodium Hydroxide 20 60 720

Ethyl acetate 540 1620 19440

Carbon 5 15 75

HCl 84 252 3024

10 Fluconazole Di fluoro benzene 150 300 3600

Chloro acetyl Chloride

160 320 3840

AlCl3 230 460 5520

Methylene di Chloride

1350 2700 32400

Hcl 300 600 7200

DM Water 3000 6000 72000

I.P.A 1100 2220 26640

Triazole 160 320 3840

Sodium nitrite 37 74 888

Ammonia 50 100 1200

KOH 100 200 2400

1,2,4 – Triazole 160 320 3840

9

Tri methyl sulfoxy iodide

50 100 1200

Methylene di Chloride

1100 2200 26400

Citric acid 25 50 600

11 Hydroxyzine Hydrochloride

4 – Chloro Benz Hydryl Piperzine

60 600 7200

Toluene 348 3480 41760

Tri Ethyl Amine 21 210 2520

HCl 550 5500 66000

2 – (2 – Chloro Ethoxy) Ethanol

55 550 6600

NaOH 48 480 5760


Acetone 470 4700 56400

Water 200 2000 24000

12 Imatinib Mesylate

AP 100 300 3600

DMFDMA 98 294 3528

ANT 250 750 9000

CM 54 162 1944

70% HNO3 105 315 3780

N-butanol 400 1200 13500

IM-II 375 1125 4032

IM-I 1112 336 972

Lye solution 27 81 900

Pd/C 10% 25 75 28800

Methanol 800 2400 2700

IM-Acid 75 225 1368

Thinyl chloride 38 114 4500

Toluene 125 375 3600

IM-IV 100 300 3276

IM-V 91 273 9000

MCL 250 750 1620

NaOH 45 135

Methane sulphonic acid

35 105 1260

13

Itraconazole 1 – (4- Methoxy phenyl) Piperzine

72.5 362.5 4350

P – Nitro Chloro Benzene

59.5 297.5 3570

D.M.F 2740 13700 164400

Potassium carbonate

55 275 3300

10

Water 4760 23800 285600

Palladium Carbon 5.5 27.5 330

Phenyl Chloro Formate

47 235 2820

Toluene 1140 5700 68400

Sodium Bi Carbonate

25.5 127.5 1530

Hydrazine Hydrate 13.5 67.5 810

1,4 - Dioxane 525 2625 31500

Acetic acid 28.5 142.5 1710

Formamide 10.5 52.5 630

2 – Bromo Butane 29.5 147.5 1770

Methanol 3350 16750 201000

Hydrogen Bromide 30 150 1800


Cis – Bromo Benzoate

90 450 5400

1,2,4 - Triazole 14 70 840

I.P.A 600 3000 36000

Methane Sulfonyl Chloride

21 105 1260

Triethylamine 18.5 92.5 1110

Potassium Hydroxide

10 50 600

Carbon 8 40 480

14 Lamivudine Α – Menthol 100 1200 14400

Cyclo Hexane 270 3240 38880

Gly Oxalic Acid 40 480 5760

H2SO4 1 12 144

NaHSO3 36 432 5184

HCHO 25 300 3600

Na2CO3 6 72 864

DM Water 1130 13560 162720

2,5-Di Hydroxy-1,4-Di Ethane

34 408 4896

T.E.A 63.5 762 9144

Toluene 555 6660 79920

n-Hexane 264 3168 38016

M.D.C 580 6960 83520

D.M.F 28 336 4032

M.S.A 0.8 9.6 115.2

SOCl2 48 576 6912

Cytosine 39 468 5616

11

H.M.D.S 67 804 9648

15

Lansoprazole Acetic Acid 80 1920 23040

3,5 Lutidine 100 2400 28800

H2O2 2171.7 52120.8 625449.6

Methanol 325 7800 93600

Sulphuric Acid 350 8400 100800

Nitric acid 175 4200 50400

DM Water 450 10800 129600

Methylene chloride 500 12000 144000

MIBK 350 8400 100800

Pottacium carbonate

80 1920 23040

Trifluoroethanol 120 2880 34560

Aceticanhydride 150 3600 43200

Toluene 325 7800 93600

IPA hydrochloride 100 2400 28800

NaOH 108 2592 31104

Carbon 9 216 2592

Sodium sulphate 20 480 5760

Methylene chloride 200 4800 57600

Thionylchloride 75 1800 21600

Acetone 450 10800 129600

Isopropyl alcohol 300 7200 86400

Chloroform 530 12750 152640

n-Hexane 90 2160 25920

Dil Acetic acid 40 960 11520

EDTA 1 24 288

16

Levocetirizine 4-Chloro benzophenone

50 1450 17400

AmmoniumFormamide

95 2755 33060

Methanol 222 6430 77256

Carbon 1 29 348

Water 640 18560 222720

IPA HCl 200 5800 69600

N-Hexane 200 5800 69600

NaOH 78 2262 27144

Methylenechloride 800 23200 278400

L(+) Tartaric Acid 29.4 852.6 10231.2

n- ethyl di isopropyl amine

50 145 17400

12

N – n- bis chloro ethyl -4-methyl

benzene sulfonamide

29 841 10092

Hydrobromic in acetic acid

64 1856 22272

4- hydroxyl benzoic acid

27 783 9396

2-chloro ethanol 13 377 4524

Tri ethyl amine 21 609 7308

toluene 250 7250 87000

2-Chloro sodium acetate

18 522 6264

Koh 10 290 3480

acetone 150 4350 52200

17

Losartan Potassium

2-Cyano-4-Bromo methyl phenyl

100 1600 19200

2 – Butyl-4-chloro-5-formyl imidazole

84 1344 16128

T.B.A.B 11.2 179.2 2150.4

NaOH 40.6 649.6 7795.2

Sodium Boro Hydride

11.2 179.2 2150.4

Methanol 796 12736 152832

DM Water 100 1600 19200

Sodium Azide 84 1344 16128

T.E.A.HCl 150 2400 28800

Toluene 708 11328 135936

n-Methyl Pyrrolidin

137 2192 26304

Water 150 2400 28800

Acetic acid 180 2880 34560


Acetone 530 8480 101760

KOH 19 304 3648

Carbon 12 192 2304

18 Mebeverine Hydrochloride

Para methoxy benzaldehyde

100 200 2400

Alpha chloro propionate

100 200 2400

Sodium methoxide (25%)

375 750 9000

HCl 98 196 2352

13

Water 1055 2110 25320

Methanol 150 300 3600

Ethylamine 40 80 960

10% Pd/C 2 4 48

Veratic acid 115 230 2760

Sodium salt of Veratic acid

120 240 2880

Di Bromo butane 600 1200 14400

Toluene 50 100 1200

TEBAC 2 4 48


M.I.B.K 150 300 3600


T.B.A.B 2 4 48

Di Chloro methane 200 400 4800

19 Meclizine Hydrochloride

Meta xylene 90 540 6480

N – Bromo succinamide

90 540 6480

Chloroform 75 450 5400

Benyl peroxide 0.5 3 36

Sodium bi carbonate

60 360 4320

Water 200 1200 14400

Toluene 1260 7560 90720

4 – Chloro Benz Hydryl Piperzine

85 510 6120

Potassium carbonate

60 360 4320

I.P.A HCl 75 450 5400

Iso Propyl Alcohol 365 2190 26280

Methanol 145 870 10440

20 Omeprazole Acetic Acid 90 1260 15120

3,5 Lutidine 100 1400 16800

H2O2 2914.6 40804.4 489652.8

Methanol 1400 19600 235200

Sulphuric Acid 320 4480 53760

Nitric acid 185 2590 31080

DM Water 700 9800 117600

Toluene 2640 36960 443520

DMS 75 1050 12600

NaOH 221 3094 37128

14

Ammonium per sulphate

180 2520 30240

Carbon 20 280 3360

Sodium Sulphate 20 280 3360

Dimethyl formamide

1.6 22.4 268.8

Thionylchloride 65 910 10920

Acetone 210 2940 35280

Mercapto-5methoxy

benzimidazole

75 1050 12600

Catalyst 0.1 1.4 16.8

Dil Acetic acid 40 560 6720

Methylenedichloride

50 700 8400

EDTA 0.1 1.4 16.8

21 Pantoprazole Maltol 100 3000 36000

Di methyl sulphate 105 3150 37800

Potassium carbonate

92 2760 33120

Acetone 2485 74550 894600

Ammonia 230 6900 82800

E.D.C 1352 40560 486720

DM Water 1970 59100 709200

POCL3 60 1800 21600

48% Lye solution 100 3000 36000

H2O2 78 2340 28080

Acetic acid 220 6600 79200

Sodium tungstate 2 60 720

Chloroform 600 18000 216000

25% lye solution 300 9000 108000


Methanol 350 10500 126000

NaOH 98 2940 35280

Acetic anhydride 120 3600 43200


SoCl2 60 1800 21600

Benzimidazole 96 2880 34560

M.D.C 1600 48000 576000

NaOCl(3.5-4.2) 1000 30000 360000

Ammonium sulphate

116 3480 41760

Carbon 16 480 5760

15

22 Paracetamol Technical paracetamol

1010 20200 242400

Activated Carbon 35 700 8400

Water 1000 20000 240000

Hydrose 2 40 480

E.D.T.A 0.30 6 72

23 Pregabalin Iso Valaraldehyde 100 3000 36000

Di ethylmalonate 161 4830 57960

Acetic acid 202 6060 72720

Di – N – Propyl amine

55 1650 19800

Hexane 390 11700 140400

Sodium cyanide 48 1440 17280

Ethanol 514 15420 185040

Toluene 2130 63900 766800

DM Water 1052 31560 378720

HCl 240 7200 86400

KOH 166 4980 59760

Methanol 260 7800 93600

Raney nickel 55 1650 19800

I.P.A 565 16950 203400

L(+) Mandallic acid 120 3600 43200

24 Sertraline Hydrochloride

Α – Napthol 100 8100 97200

1,2 – Di Chloro Benzene

300 24300 291600

AlCl3 150 12150 145800

Methanol 1270 102870 1234440

Mono Methyl Amine in

Methanol(25%)

310 25110 301320

Sodium Boro Hydride

11 891 10692

HCl 65 5265 63180

D (-) Mandilic Acid 43 3483 41796

Ethyl Acetate 790 63990 767880

Sodium Sulphate 32 2592 31104

Activate Carbon 6 486 5832

Methanolic HCl (25%)

50 4050 48600

Acetone 10 810 9720

C.S.Flakes 7 567 6804

Lq.Ammonia 25 2025 24300

16

25 Telmisartan Methyl-4-amino-3-methyl benzoic acid

100 2500 30000

SOCl2 102 2550 30600

Methanol 1843 46075 552900

Ammonia 300 7500 90000

Methyl-4-amino-3-methyl benzoate

110 2750 33000

M.D.C 660 16500 198000

NaHCO3 110 2750 33000

Butyryl Chloride 110 2750 33000

DM Water 2900 72500 870000

Hexane 390 9750 117000

HNO3 390 9750 117000

Raney nickel 9 225 2700


NaOH 42 1050 12600


N.M.B – I 68 1700 20400

Poly Phosphoric acid

500 12500 150000

Ammonia solution 470 11750 141000

Sodium hydride (60%)

13 325 3900

BPC-II 85 2125 25500

1,2di methoxy ethane

396 9900 118800

26 Tramadol Hydrochloride

Cyclohexanone 180 720 8640

IPA 600 2400 28800

DMA HCl 75 300 3600

Acetone 620 2480 29760

P.formaldehyde 40 160 1920

NaOH 35 140 1680

n-Hexane 450 1800 21600

Water 410 1640 19680


MBA mute brano amisde

105 420 5040

Mg turnings 25 100 1200

Di pormo ethane 135 540 6480

THF 500 2000 24000

AMM Chloride 20 80 960

Methanol 160 640 7680

17

Fuming HNO3 45 180 2160

Toluene 300 1200 14400

C.S.Flakes 35 140 1680

D.M.Water 200 800 9600

IPA 500 2000 24000

IPA HCl (30%) 15 60 720

Carbon 3 12 144

N.Hexane 15 60 720

27 Zidovudine Beta Thymidine 100 300 3600

Trityl Chloride 150 450 5400

1,4 dioxane 1320 3960 47520

T.E.A 560 1680 20160

Toluene 348 1044 12528

DM Water 790 2370 28440

M.D.C 1030 3090 37080

M.S.Chloride 70 210 2520

Methanol 990 2970 35640

28

Cefuroxime Axetil

n-n-Dimethyl Acetamide

477 4770 57240

Cefuroxime Acid 100 1000 12000

Sodium carbonate 15 150 1800

Acetoxy Ethyl Bromide

78 780 9360

Ethyl Acetate 520 5200 62400

DM water 782 7820 93840

Sodium metabisulphite

10 100 1200

Sodium chloride 40 400 4800

Sodium bicarbonate

7 70 840

Hydrochloric acid 9 90 1080

Cyclohexane 456 4560 54720

Acetone 59 590 7080

Carbon 10 100 1200

Methanol 174 1740 20880

29 Atorvastatin Calcium

Ethyl cyano – 3- hydroxyl Butanoite

40 400 4800

Lithium HMDS 20% in THF

340 3400 40800

Tertiary Butyl Acetate

111 1110 13320

HCl 220 2200 26400


18

THF 150 1500 18000

Methanol 720 7200 86400

Diethyl methoxy boran

56 560 6720

SBH 7.5 75 900

MDC 750 7500 90000

Sodiumchloride 15 150 1800



Pt ether 570 5700 68400

2,2,dimethoxy propane

120 1200 14400

Methane sulphonic acid

2 20 240

Sodium bicarbonate

37 370 4440

RNC 50 500 6000

Liq.Ammonia 50 500 6000

Cyclohexane 450 4500 54000

Pavulic Acid 6 60 720

Di ketone 50 500 6000

IPA 320 3200 38400

SBC 150 1500 18000

Water 100 1000 12000

Acetonitrile 400 4000 48000

HCl 18 180 2160

Sodium hydroxide 8 80 960

Carbon 4 40 480

Toluene 400 4000 48000

Calcium acetate 18 180 2160