The actions and applications of the Solgar Full Spectrum Curcumin 185x.

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• Curcumin is the principal active curcuminoid in Turmeric• traditionally used for a wide range of ailments including skin

conditions, eye health, stomach complaints, infections and various inflammatory conditions.

• Turmeric supplements provide a concentrated source of those important curcuminoids and are usually standardised to 93-95% per capsule or tablet so a 500mg capsule would provide approx. 470mg curcuminoids.

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Research has increased over the last 10-15 years as curcumin.

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• Often an inflammatory component to many of the health concerns we just considered -Curcumin has a broad yet strong anti-inflammatory action

• Detoxification support comes through the production of antioxidant enzymes in the liver.

• Anti-inflammation and detoxification are probably the best known actions for curcumin and this has been shown to help some people with inflammation-based gut health conditions.

• Majority of research on curcumin relates to Gastro-intestinal inflammation.• Also has anti-microbial action against fungi and gut parasites as well as bacteria. • Anti-bacterial action often accounts for the use of curcumin for skin complaints as

well as reduce the inflammation in damaged tissues.• Cardiovascular health is supported through curcumin’s antioxidant activity which

can help reduce oxidative stress damage to the vascular walls which would in turn trigger inflammation.

• Antioxidant action helps protect fats e.g. cholesterol and triglycerides. • Helps reduce total overall cholesterol level & LDL cholesterol and raise HDL levels• Protects the fatty tissues of the brain but also its anti-inflammatory action will

combat inflammatory chemicals known to have a negative effect on brain & nerve function, mood and cognitive function

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1. Curcumin has relatively poor absorption capabilities which is exacerbated by existing inflammatory conditions of the digestive tract which further hinders the absorption not only of dietary fats but also of curcumin.

2. Bioavailability to the body is hindered due to rapid turnover of curcumin in the liver and intestinal walls, affecting systemic levels.

Systemic levels are going to be hard to improve because ingesting more curcumin is not necessarily going to improve the absorption or systemic levels!

So even though there’s preferential accumulation in the gut, giving it preference doesn’t guarantee the levels that will accumulate to tackle the inflamed gut. . . .and even if it did, it’s further reducing the chances of any appreciable systemic levels. If we want to use curcumin for cardiovascular or brain/nerve health or joint health we need to overcome this barrier to its absorption and utilisation systemically.

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Fat digestion reviewed.• Bile salts make ‘natures micelles’ with their fat-attracted ends locking into the fat

or fatty nutrient and leaving the water-loving ends to render the micelle ‘water-soluble’. This ensures that the micelle can be dispersed through the water layer surrounding the villi and reach the microvilli.

• Micelles should be small enough to pass between the tiny gaps of microvilli so they can be absorbed and utilized. These gaps are only 50 nanometers in diameter

• Micelle release the fatty substance at the tissue surface for maximum absorption potential of the fat. Micelle material is removed with the waste.

• Micellation is a natural process for the absorption and digestion of fats and fatty substances so if there is any liver or gallbladder insufficiency micellation will be extremely difficult.

• Curcuminoids in Turmeric are fatty compounds, micellation by bile will be required however curcumin is metabolised and removed so quickly in the gut that micellation is poor.

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The solution: follow nature’s lead and use micellation in the processing of the product to maximise absorption and bioavailability. Solgar uses a patented curcumin material from NovaSol.

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• You will recognise the section on the left of the diagram here where we are reminded of how fats in food are micellised in order to be absorbed. Remember Liver and gallbladder insufficiency will hinder this action.

• In the middle, we see an emulsified curcumin product which provides some improvement in absorption potential however it still requires the micellisationprocess

• On the right hand side, we see the form of curcumin that Solgar is using. As you can see, the curcumin has been both emulsified and micellised leading to enhanced absorption.

• Remember micelles must be small enough to fit between the microvilli – less than 50nm in diameter – and be water soluble in order to pass efficiently through the water layer along the brush border.

This patented process of the Solgar Full-Spectrum Curcumin 185x enables it to reach those important absorption sites and be small enough to fit which enhances their absorption rate and quantity. This means the curcumin is reaching beyond the tissues of the gut to enter the blood plasma and enabling the systemic levels of curcumin to rise. This achieves better systemic availability and improves levels in the gut lining and the liver.

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• imitating the action of bile on fatty compounds in the diet . • product is stable in a wide range of pH levels from acid to alkaline including

digestive secretion.• patented process uses a micellation compound which provides a fat-soluble and

water-soluble portion enabling the curcumin to reach the microvilli in tiny micelles.

• systemic circulation capabilities

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• 40mg of curcumin - remember the bioavailability of this product is 185 times that of native curcumin so this product has the equivalent of 8,880mg total curcuminoids

• If you cannot metabolise fatty substances efficiently due to digestive insufficiencies then taking non-micellised forms may not be of great benefit outside the gut.

• If we are looking to increase plasma levels of curcumin so that it can have positive effects on the health of the brain, liver, skin and cardiovascular health then we must use this micelle form.

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Anti-inflammatory actions of Curcumin. Mediators of inflammation which are down-regulated by Curcumin.

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1. NFkB is activated by Oxidative stress = activation of TNFalpha which causes fever and inflammation.

2. NFkB also reduces the rate of apoptosis (cell recognises malfunction and induces its own death) Apoptosis or cell death is preferable to cells’ proliferating or multiplying when they are malfunctioning

So NFkB interferes with the usual lifecycle of the cells. Curcumin is able to down-regulate NFkB - reducing inflammation and restoring order in the cells.

Omega 6 fatty acid pathways . 1. Preferred pathway for health = series 1 prostaglandins which have an anti-inflammatory

action and are shown by the grey arrows. Enzymes in the Omega 6 pathway prioritise the production of Prostaglandin series 1

2. Production of arachidonic acid – which can convert to series 2 prostaglandins and certain leukotrienes which can cause inflammation – shown with the yellow arrows.

• Meat & dairy are the greatest dietary source of arachidonic acid = increase inflammatory compounds. Reduce intake of meat and dairy and increase Omega 3 fatty acid EPA found in oily fish to reduce Arachidonic acid production and activity,

• Curcumin has a modulating effect on the specific enzymes which mediate the production of inflammatory prostaglandins and leukotrienes i.e. COX2 & 5LOX enzymes

Summary:• EPA helps control arachadonic acid conversion to inflammatory compounds• Curcumin regulates action of COX2 and 5LOX enzymes which promote inflammatory

compounds

If you want to know more about the action of these inflammatory compounds and joint health, please see the Solgar 7 e-learning presentation.

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• Stress – can trigger oversensitivity of the hypothalamus which can result in increase cortisol and insulin levels which can result in obesity.

• Obesity involves an increase in white fat cells and these can store inflammatory chemicals. Chronic systemic inflammation impacts on blood sugar control, immune function, nerve function and cellular function.

• Sugar triggers insulin production and if the diet provides too much sugar then the insulin responds by storing it as white fat =increased obesity risk. Glycationdamage triggers an inflammatory reaction in vascular walls.

• Smoking also causes damage to the vascular walls and is a source of free radicals and toxic compounds = poor cell function and inflammation of the tissues.

• Meat and dairy are sources of arachidonic acid so it’s worth considering reducing the intake of these foods in chronic inflammatory conditions.

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Diet to help control inflammation• Eat plenty of vegetables – they have a low glycaemic loading and are high in

protective antioxidants. Fibre content also helps to clear the intestinal tract of toxins and support the gut microbiome. Avoid processed foods (low in fibre and nutrients/ high on saturated fats, salt and sugar).

• Foods with a Low glycaemic load will also help to control blood sugar levels and insulin production.

• Diets high in fish and omega 3 oils will provide EPA to ‘balance’ the omega 6 oils and block the action of arachidonic acid

• Avoid ‘hydrogenated’ ,‘partially-hydrogenated’ & high saturated fat fats which encourage inflammation

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Weight control• manage weight – fat cells can secrete inflammatory factors so the more fat cells

you have, the greater the potential for inflammation.• Reduce calorie consumption - High calorie consumption can increase the release

of inflammatory triggers & decrease immunity. • Sleep well! It is restorative to the immune system and reduces inflammatory

chemical production. Pain and inflammation are worse when we don’t sleep well.• Reduce stress!!! Repeated acute stress or chronic stress can produce long term

inflammatory responses in the tissues and organs of the body.

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• COX enzymes are a family of enzymes responsible for the production of either inflammatory or anti-inflammatory compounds.

• COX 2 is pro-inflammatory instigator and • COX1 is anti-inflammatory

NOTE: Curcumin selectively suppresses COX 2 but not COX 1

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• Studies using 1200mg of ibuprofen per day versus 1500mg curcumin in osteoarthritis of the knee

• Showed comparative results for pain, stiffness and function of the joint over the 4 week period.

• Curcumin keeps pace with ibuprofen – a NSAID! • Direct comparison shows the systemic effect curcumin can have when presented

to the body in this highly absorbable form.

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This lady took the micellised curcumin daily for 9 months – and the colonoscopy photos show impressive results.

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As a result of this research and development in micellised curcumin, new doors have been opened for the application of curcumin in other health concerns previously limited by the lack of bioavailabilty.

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• Detoxification through the liver is complicated but the key here is the phase 1 and phase 2

• During the detoxification of harmful compounds, phase 1 produces intermediate compounds which have the potential to be even more damaging to the liver so it’s important that those compounds are produced slowly . . .and removed quickly.

• Curcumin slows phase 1 and stimulates phase 2• Curcumin has antioxidant action so it can help protect the liver from potential

damage from those compounds. • Curcumin produces antioxidant enzymes like glutathione & increases bile

production and flow - all of which help liver detoxification.

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INFLAMMATION.Solgar 7 – patented ingredients; tackles inflammation, cartilage protection and joint and collagen support.Celadrin - patented, esterified fatty acid with broad acting anti-inflammatory action. Can inhibit COX2, PGE2 and CRProtein amongst others; penetrates cell membranes and gives them stability and integrity against damage; helps reduce aches and pains; helpful in psoriasis.Cherry Turmeric complex - inflammation and tissue strength; bioflavonoid contentSolgar Triple strength Omega 3 – high EPA content can target that Arachadonic acid in the Omega 6 pathway; maintain fluid cell membranes for efficient membrane function including maintaining fluid balance in the cell, transport of nutrients into the cell and removal of toxins from the cell and receptor function. Quercetin complex contains quercetin, bromelain and Ester C and MSM is a sulphur compound; anti-inflammatory action primarily on histamine; strengthening and repairing connective tissue. Sulphurous antioxidants -.sulphur based compounds; support liver detoxification and provide antioxidant action against oxidative stress in the liver and the body. Alpha lipoic acid is a sulphur-based enzyme with similar actions; antioxidant plus it helps to ‘recycle’ certain antioxidant nutrients (carotenoids, C and E)

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DIGESTIONComfort Zone - complete digestion of foods including fibrous veg, beans and pulses and lactose in milk.Glutamine is well known for it’s application in gut healing. Probi Lp299v - patented single strain probiotic; act as a physical barrier to pathogenic organism; support gut mucosa; inhibit ‘leaky gut’; modulate immune response in the gut.Stress can impact on inflammation through its effects on the hypothalamus in the brain which can become oversensitive and effect cortisol and insulin levels. Keeping stress levels down will benefit overall health and help to reduce inflammation.

STRESSAshwagandha - adaptogenic herb; nerve tonic properties; anti-inflammatory; antimicrobial.Balance Rhodiola complex - botanicals and nutrients for stress support; Rhodiolacalms over-sensitive hypothalamus; includes calminative chamomile; adrenal-supporting licorice root, tyrosine and siberian ginseng; nutrients e.g. magnesium, Ester C, pantothenic acid.

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BRAINInflammation and oxidative stress affect the health of the brain too. Combine the with the anti-inflammatory action of CurcuminMetafolin – folate form that can cross the blood brain barrier; methyl donor; supports vascular system and neurotransmitter production.Homocysteine modulators – complex; supplies methyl donors TMG, B6 and B12 & standard folate; modulates negative effect of Homocysteine Neuro-nutrients - a range of amino acids with some key nutrients and ginkgo biloba; supports neurotransmitter production and capillary circulation.

NUTRITIONAL SUPPORTOmnium – antioxidant-rich multiple; nutrients; antioxidant compounds like CoQ10, quercetin, broccoli, polyphenols etc.MultiPlus with Brain Essentials – specific focus; supportive botanical complex of ginkgo, rosemary and Holy Basil. Vitamin D - deficiency in many who suffer with low mood and SAD

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More through bioavailability being 185 times greater than that of native curcumin & providing the equivalent of 7,400mg curcumin in ONE capsule

Better availability to the whole body as micellation improves absorption and increases the levels available to the whole body, not just the gut.

Faster action with absorption being nearly 7 times faster than native curcumin.

Proven by research.

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