The American Physiological Society

March 2008

WATER AND ELECTROLYTE HOMEOSTASIS SECTION NEWSLETTER

News from the Chair, David P. Brooks

Once again the Experimental Biology meeting is fast approaching and the WEH Section has another very exciting program. We are particularly excited about being able to include the “APS Water and Electrolyte Homoeostasis Section Trainee Awards Symposium” for a second year. We are most grateful to our colleagues at Data Sciences, Inc. who have again provided an educational grant that makes this symposium possible. I encourage you to make every effort to attend this session to hear and support our younger colleagues. Details of this program and the finalists are provided below. Other highlights of the program include lectures by our 2008 Starling Lecturer, Dr. Joey Granger, and our New Investigator Award recipient, Dr. Michael Ryan. In addition to attending these and other WEH Section sponsored sessions, I encourage you to attend the Business Meeting and Luncheon where you will have a chance to meet and congratulate all these speakers. At this meeting we will also be asking our members to approve the Section’s Statement of Organization and Procedure (see pages 6-7), which has recently been updated and approved by the Steering Committee. I look forward to seeing you all in San Diego in April.

WEH-Sponsored Sessions at Experimental Biology 2008

TIME Saturday April 5

Sunday April 6

Monday April 7

Tuesday April 8

Wednesday April 9

8:00 am to

10:00 am

WEH Featured Topic

Renal and Circulatory

Physiology and Pathophysiology in

Metabolic Syndrome

(Room 28B)

WEH Featured Topic

Neurohypophyseal

Hormones: Regulatory Control in Health and

Disease (Room 25A)

10:30 am

to 12:30 pm

11:45 am WEH Business

Luncheon Asti Ristorante

POSTER SESSIONS

12 noon to

3:00 pm

WEH • Inflammation • Neural Control • Renin

Angiotensin System

WEH • Hypertension • Metabolic

Syndrome • Sex-

Dependent

WEH • Water&Electrolyte

Homeostasis • Neurohypophyseal

Hormones

PLENARY 3:15 pm

to 5:15 pm

4:00 pm WEH Awards

Finalists (Room 28B)

5:45 pm Cannon Lecture

7:00 pm APS Reception

3:15 pm WEH

Starling Lecture (Room 24)

4:15 pm

WEH YIA Lecture (Room 24)

WEH Featured Topic

Hypertension:

Integrated Mechanisms and

Sequelae (Room 24)

WEH Symposium

Roles of Oxytocin and Vasopressin in Clinical

Disorders (Room 28B)

Disclaimer: Please check program for room number. Presenters should not use this as final notification. * Starling Lecture and Young Investigator Award (YIA) Lecture will be presented in the same session.

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WEH Trainee Finalist Awards Symposium Six Trainee finalists have been selected to present their work in a WEH Sponsored

Session on Saturday, April 5, 4:00-5:15 pm, Room 28B. Each finalist will give a 7 min oral presentation with 3 min for questions. The judging committee is comprised of the At-Large Councilors and members of the Steering Committee. The postdoctoral finalists are: J. Gilbert, Univ. of Mississippi; T. Rieg, Univ. California at San Diego; and L. Tang, Wake Forest Univ. The student finalists are: B. Houghton, Univ. College Cork; F. McBryde, Univ. of Auckland; and F. Spradley, Medical College of Georgia. Data Sciences, Inc (DSI) is co-sponsoring the Awards Symposium with an unrestricted educational grant. The winners will be announced at the WEH Business luncheon on Sunday, April 6, 2008.

EB 2008 WEH Business Luncheon Sunday, April 6, 2008 Jennifer Pollock, WEH Secretary/Treasurer Please plan on attending the Annual WEH Business Luncheon at EB 2008 that will take place on Sunday, April 6, 2008, 11:45 am to 1:15 pm at the Asti Ristorante in the Gaslamp

Quarter, 728 5th Ave, San Diego, CA, 619-232-8844. The WEH Fellow and Student Awardees will be announced at the luncheon. The luncheon cost is $5 for Students or Fellows and $20 for all other attendees. Tickets are ordered online at: https://www.the-aps.org/cgi-bin/ecom/eticket/ticket_list.cgi until March 20, 2008. Questions should be directed to Jennifer Pollock (jpollock@mcg.edu) or Linda Allen at APS (lallen@the-aps.org).

2008 Ernest H. Starling Distinguished Lectureship Joey P. Granger, PhD

We are honored to have Dr. Joey P. Granger present the Ernest H. Starling Distinguished Lecture at the 2008 Experimental Biology meeting. Dr. Joey Granger is the Billy S. Guyton Distinguished Professor and Professor of Physiology and Medicine at the University of Mississippi School of Medicine. Dr. Granger will also attend our annual business meeting/luncheon on Sunday, April 6 where he will meet with trainees and WEH members. Dr. Granger’s lecture is programmed in a WEH Plenary Session on Sunday, April 6 at 3:15 pm in Room 24.

2008 Young Investigator Award in Regulatory and Integrative Physiology to be presented to Michael J. Ryan, PhD

Dr. Michael Ryan, Assistant Professor, from the University of Mississippi, Department of Physiology and Biophysics has been selected as the 2008 Young Investigator Awardee. Dr. Ryan’s lecture will be presented in the WEH Plenary Session on Sunday, April 6 at 4:15 pm in Room 24. Mike received his PhD in

Physiology and Biophysics at the University at Buffalo followed by a postdoctoral fellowship at the University of Iowa with Dr. Curt Sigmund. Dr. Ryan’s current research focuses on the autoimmune disorder systemic lupus erythematosus as a disease model for investigating the contribution of chronic inflammation to the development of hypertension. He is also a really nice guy!

The Young Investigator Award in Regulatory and Integrative Physiology was established to encourage young investigators to continue research careers in cardiovascular, renal, and neuroendocrine integration. The award is presented annually at the business luncheon of the Water and Electrolyte Homeostasis Section to a new investigator who has made important contributions to our understanding of the integrative aspects of cardiovascular, renal, and neuroendocrine physiology in health and/or disease.

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APS Joint Programming Committee Michael Brands, WEH Representative

Please see the WEH Pocket Planner for an outline of the "can't miss" sessions for EB 2008, and note especially the Saturday afternoon events. The Awards Session, sponsored by DSI, was a huge success last year, and it makes for a great opening to the meeting. Please plan your flights accordingly.

WEH programmed 154 abstracts for EB 2008, a new high which made WEH the 6th highest in APS in numbers of abstracts this year. The Hypertension Featured Topic drew a record 41 submissions, and it again will be co-chaired by the Chair of the AHA Council for High Blood Pressure Research. There are no Wednesday sessions for WEH in this, my last, year as your JPC

representative, so that is extra incentive to make it to San Diego in time for Saturday's programming! Jane Reckelhoff will be replacing me as the WEH Representative to the JPC beginning at EB08, so she will be your contact person for the next three years.

WEH Sponsored Sessions

Saturday, April 5 4:00--5:15 PM Room 28B DSI-WEH Student/Fellow Awards Symposium Chairs: Carolyn Ecelbarger and David Mattson Sunday, April 6 3:15--4:15 PM Room 24 Ernest H. Starling Lectureship Joey Granger, Univ. of Mississippi Medical Center “Hypertension During Preeclampsia: A Lesson In Integrative Physiology” Sunday, April 6 4:15--5:15 PM Room 24 WEH Young Investigator Award Lecture Michael J. Ryan, Univ of Mississippi Medical Center “Pathophysiology of Hypertension in Systemic lupus Erythematosus”

WEH Featured Topics Sunday, April 6 8:00--10:00 AM Room 28B Renal and Circulatory Physiology and Pathophysiology in Metabolic Syndrome Chair: Carolyn Ecelbarger Invited Lecturer: James R. Sowers, Univ. of Missouri Hlth. Sci. Ctr. “Pathophysiological factors connecting renal and vascular disease” Monday, April 7 3:15--5:15 PM Room 24 Hypertension: Integrated Mechanisms and Sequelae Chair: Michael W. Brands Invited Lecturer: Timothy L. Reudelhuber, IRCM, Montreal “In vivo strategies in the search for new targets in the renin-angiotensin system” Tuesday, April 8 8:00—10:00 AM Room 25 Neurohypophyseal Hormones: Regulatory Control in Health and Disease Chairs: Thomas Cunningham and Catherine Uyehara Invited Lecturer: Celia Sladek, Univ. of Colorado Hlth. Sci. Ctr. “Regulation of neurohypophyseal release by co-released neurotransmitters”

WEH Sponsored Symposium

Tuesday, April 8 3:15--5:15 PM Room 28B Roles of Vasopressin and Oxytocin in Clinical Disorders Chairs: Sudar Alagarsamy and Catherine Uyehara

See EB’08 Website: http://www.eb2008.org/

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APS Joint Programming Committee

Jane Reckelhoff, WEH Representative NOTICE: Now is the time to develop new ideas about Symposia and Featured Topics for EB’09 in New Orleans. Both Symposia and Featured Topic presentations are 2 hrs long. A symposium has 4 pre-named speakers, whereas a Featured topic has 1 main speaker and the rest of the presentations are programmed from abstracts submitted to that topic. The deadline for submission is May 1, 2008. Please contact Jane Reckelhoff with your ideas prior to or at EB’08 (jreckelhoff@physiology.umsmed.edu).

APS Laision with Industry Committee (LWIC) Magdalena Alonso-Galicia, WEH Representative The APS LWIC is sponsoring a Symposium at EB 08 entitled "IBS and Chronic Constipation: Mechanisms and Novel Treatments" on Monday, April 7 from 3:15 – 5:15 PM in the Convention Center, Room 25A. This symposium will focus on the mechanisms of these two GI disorders that affect ~15-25% of the US population as well as current treatments and their mechanisms of actions and efficacy, as well as novel treatments being developed for these debilitating diseases.

In addition, the APS and LWIC are co-sponsoring a Translational Physiology Symposium entitled “Recent Advances in the Renin-Angiotensin-Aldosterone System for the Investigation and Treatment of Hypertension”. This symposium will display the “bench-to-bedside” scope of translational research by highlighting recent findings from transgenic mice, local renal angiotensin II production and function as well as clinical trial data and the advance and clinical application of a renin inhibitor. Look for the full program on-line at http://www.the-aps.org/meetings/eb08/program.htm.

You're invited! Come meet and eat with your fellow Physiologists who

are working in the corporate sector. The 8th Annual Liaison With Industry Committee Mixer at EB ‘08 is on Sunday, April 6th, 7:00 – 9:00 PM in room Torrance Room of the San Diego Marriott Hotel. Free Hors d’oeuvres will be available along with a cash bar – hope to see you there!

The LWIC Novel Disease Model Award will be granted to each a graduate

student and a postdoctoral fellow who submit the best abstracts at EB ‘08 that describe a novel disease model. The model can be in vitro or in vivo but should clearly emphasize the potential utility of the system for future research related to a disease. The award is $500 for the graduate student and $800 for the postdoctoral fellow and is sponsored by the LWIC and the APS.

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APS Trainee Advisory Committee (TAC) Jennifer Sasser, WEH Representative

Once again, we would like to thank Data Sciences, Inc for co-sponsoring the WEH Trainee Awards Symposium. Please join us at the symposium on Saturday, April 5 for the symposium and then again on Sunday, April 6 for the presentation of the Awards at our annual Business Luncheon. At the luncheon, trainees will also have the opportunity to meet the 2008 Ernest H. Starling Distinguished Lecturer, Dr. Joey Granger, and the 2008 WEH New Investigator Awardee, Dr. Michael Ryan.

The APS TAC is involved in trainee-related issues on many levels of ranging from undergraduate to junior faculty. Please join us for this year’s TAC symposium at EB ’08, “Marketing Yourself on Paper for Academic Positions” (Sunday, April 6, 8:00 AM-10:00 AM, Room 25C) which will focus on writing cover

letters and research and teaching statements for faculty position applications. This symposium will complement the symposium sponsored by the APS Women in Physiology and ASPET Women in Pharmacology Committees, “Gainfully Employed: From Launching a Job Search to Navigating Negotiations” (Tuesday, April 8, 8:00 AM-10:00 AM, Room 28A). For more information on the TAC and other trainee issues, including career planning and job searches, visit the TAC website (http://www.the-aps.org/trainees/) and sign up for the Trainee LISTSERV to receive valuable information by email.

New APS Trainee Member Benefit: All APS trainee members are now eligible to participate in MentorNet, an award-winning one-on-one mentoring program. The program lasts for 8 months. It allows trainees to indicate the issues they are most interested in discussing and to select the type of mentor they would like to have. For information on how to sign up, go to http://www.the-aps.org/careers/careers1/mentor/guide.htm.

Tom Cunningham elected WEH Secretary/Treasurer Congratulations to Tom Cunningham! The WEH Section recently had an election for the Secretary/Treasurer position on the Steering Committee. Tom Cunningham will assume the duties as Secretary/Treasurer at the EB 2008 meeting and his term will end with EB 2011. Tom has been an At-large Councilor on the Steering Committee and recently headed up the Awards judging. Dr. Cunningham is a Professor

at the Univ Texas Health Science Center in San Antonio.

APS Committee on Committees Jane Reckelhoff, WEH Committee on Committees Representative Although we are the smallest section in terms of numbers of members, WEH has historically had representation on most of the APS committees. The way the process works, the Committee on Committees meets at EB every year and makes recommendations for the APS Committee assignments. The Council then approves the appointment in the summer for appointments to begin in January of the following year. We will be soliciting again for volunteers for appointment to the 2010 committees in November/December 2008. If you are interested in being nominated for a Committee, please contact me. It is a great way to find out how things work at APS. Even if you were nominated in the past and didn’t make it, please try again. Re-nomination is not

looked upon as a negative since there are often many qualified candidates nominated for the same committee. Also, if you have aspirations of becoming an officer of APS, most start by performing committee service. Young investigators, please do not hesitate to nominate yourself. See you at EB2008! Jennifer Pollock will be replacing me as the WEH Committee on Committees Representative beginning at EB 08, please contact her for nominations (Jennifer Pollock; jpollock@mcg.edu)

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AJP: Regulatory, Integrative and Comparative Physiology Dr. Curt Sigmund, Editor-In-Chief

Greetings from AJP: Regulatory, Integrative and Comparative Physiology. It has been just over 6 months since we started adjudicating the journal. Just as we have all figured out how to work the Scholar One peer review system, we will be switching to eJournalPress. My conversations with the other editors suggests that, in the end, the move will be very beneficial. You can expect to be asked sometime soon to update your keywords, please do so expeditiously and this greatly enhances our ability to identify the best and most appropriate reviewers.

We have two calls currently listed on our journal website (http://ajpregu.physiology.org/). The Call for Papers is entitled “Neural Integration of

Peripheral Signals Implicated in the Control of Energy Homeostasis and Metabolism” which includes cellular/molecular, biochemical, integrative, comparative, and translational studies. I urge those of you working in this area to consider submitting your best work in response to this call. The due date for those submissions is June 30, 2008. We have also recently released a “Call for Proposals for Review Articles”. Instructions for responding to this solicitation through a pre-submission inquiry will be on the journal Website soon. As always, I look forward to hearing your thoughts and ideas. You can contact me through our editorial office at ajp-regulatory@uiowa.edu.

APS Elects New Officers The WEH Section of the APS

extends its congratulations and looks forward to the leadership of the new officers. The Society is pleased to announce that the election winners. President-elect: Gary Sieck, Mayo Clinic Councillors: Gordon Mitchell, Univ Wisconsin

Frank Powell, Univ California San Diego Linda Samuelson, Univ Michigan.

Water and Electrolyte Homeostasis Section Section Statement of Organization and Procedure (Approved by Council April 1982; Amended March 1989; Revised July 1999, Revised November 2007) ARTICLE I. Name The name of this organization is the WATER AND ELECTROLYTE HOMEOSTASIS SECTION (WEH) OF THE AMERICAN PHYSIOLOGICAL SOCIETY ARTICLE II. Purpose The purposes of this Section are to: Advise the Society on matters of interest to the members of the Section. Assist the Society, through representation on the Joint Program Committee, in the organization of the scientific meetings of the Society. Nominate individuals for membership on Society committees. Be open to all members of the Society expressing an interest in Section membership. Provide the President-Elect with recommendations of and supporting material for individuals to be nominated by the Society for awards. To recognize members who have made significant contributions to the affairs of the Section and the Society.

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ARTICLE III. Membership Membership is open to any member of the Society (student, affiliate, regular, emeritus, corresponding, or honorary) who wishes to become a member. Section membership is conferred by designating Water and Electrolyte Homeostasis Section as a primary, secondary, or tertiary section for affiliation through the APS Membership Services Department. ARTICLE IV. Officers Section 1. Steering Committee The responsibility for management and supervision of the affairs of the Section shall be vested in a Steering Committee. The members of the Steering Committee shall be the Section Chair, the Secretary-Treasurer, the Committee on Committees Representative, the Joint Program Committee (JPC) Representative, the Liaison with Industry Committee Representative, five councilors (three At-Large councilors, one Translational Physiology Representative, and one International Representative), a Trainee Member, and the editor of the American Journal of Physiology: Regulatory, Integrative and Comparative Physiology (ex-officio, non-voting). Other non-voting members (in training), if applicable, will include (prior to their taking office), the newly elected Section Chair, Secretary-Treasurer, JPC Representative, and Committee on Committees Representative. The Section Chair will serve as the Section Advisory Committee (SAC) Representative. A quorum for conducting official business for the Section will be six of the twelve members of the Steering Committee. The Steering Committee will meet or converse twice yearly, i.e., at the annual spring meeting, at a fall conference of the Society, by conference call, or at the meeting of a parallel-interest society. Section 2. Steering Committee Members and Their Duties The Steering Committee members shall serve a three-year term and those terms shall overlap as much as possible to insure continuity on the Steering Committee. The Section Chair shall call and chair meetings of the Steering Committee and supervise the election process in coordination with the Secretary-Treasurer. The Chair may appoint committees that are necessary for the proper conduct of the affairs of the Section. The Secretary-Treasurer shall keep the minutes of the Steering Committee and the membership list, prepare and send the newsletter to the membership of the Section and maintain fiscal records. The JPC Representative coordinates the efforts of the Section to program its oral and poster sessions and symposia at Experimental Biology, and also represents the Section at meetings of the JPC. The JPC Representative annually appeals to WEH Section members to volunteer to organize oral sessions for the next EB meeting The submitted ideas are organized and submitted to the Section Chair, who will work with the JPC Representative, and organize a subcommittee if necessary, to make the selections. The overall scope of WEH programming should be discussed annually by the WEH Steering Committee to provide continuous programming evaluation, oversight, and guidance for both the Section Chair and the JPC Representative. Section 3. Election of Officers and Terms of Office The terms of office shall be for three years. The Chair should have served on the Steering Committee prior to being elected to office. The Chair and Secretary-Treasurer will be elected by ballot vote of the regular membership with a primary affiliation in the Water and Electrolyte Homeostasis Section prior to the expiration of his/her respective term as a committee member, and on the occasion of an election for membership on the Steering Committee. Election of the Chair and Secretary-Treasurer will be by ballot distribution and counted by the Membership Services Department of the Society. Other voting members of the Steering Committee will be elected by the Steering Committee. The election for the Chair, the Secretary-Treasurer, the Committee on Committees Representative, and the Joint Program Committee (JPC) Representative will be held one year prior to the expiration of the predecessor’s term. This will provide the newly-elected officers time to obtain valuable experience and insure continuity in the Steering Committee. Terms of office of all members of the Steering Committee will begin and end at the close of the annual spring meeting of the Society. Section 4. Nomination for Membership on the Steering Committee Nomination for membership on the Steering Committee will be made annually, as appropriate, by the Section’s membership in response to a request by the Steering Committee. The election shall be scheduled to take place prior to the annual spring meeting of the Society. ARTICLE V. Dues Dues will not be assessed. ARTICLE VI. Amendments and Quorum of the Membership Section 1. Amendments Amendments to these procedures must be proposed in writing to the Steering Committee by five members at least two months prior to the annual meeting of the membership which normally will be held at the Society’s spring meeting. The proposal must then be sent to the members prior to the annual meeting of the membership. Amendment requires the approval of two-thirds of a quorum. Section 2. Quorum The quorum for all membership business meetings is no less than 25 members of the Section. ARTICLE VII. Awards Awards will be made as financial and other circumstances permit in order to recognize members of the Section and the Society who have made substantial contributions to the affairs of the Section and the Society. Student and new investigator awards will also be made when appropriate. Nominations for awards will be accepted when called for by instructions published in a newsletter.

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Water and Electrolyte Homeostasis Section

2007-08 Steering Committee

David P. Brooks, PhD (Chair and SAC Representative to APS) GlaxoSmithKline Pharmaceutical King of Prussia, PA 19406 Phone: 610-270-6795 Fax: 610-270-5681 E-mail: david.p.brooks@gsk.com Michael W. Brands, PhD (JPC Rep to APS) Medical College of Georgia Augusta, GA 30912 Phone: 706-721-9785 Fax: 706-721-7299 Email: mbrands@mcg.edu Jennifer S. Pollock, PhD (Secretary/Treasurer) Medical College of Georgia Augusta, GA 30912 Phone: 706-721-8514 Fax: 706-721-9799 E-mail: jpollock@mcg.edu Jane F. Reckelhoff, PhD (Committee on Committees Representative to APS) University of Mississippi Medical Center Jackson, MS 39216-4505 Phone: 601-984-1819 Fax: 601-984-1817 E-mail: jreckelhoff@physiology.umsmed.edu Jennifer M. Sasser, PhD (Trainee Advisory Committee Representative to APS) University of Florida Gainesville, FL 32610-0274 Phone: 352-392-8151 E-mail: jmsasser@ufl.edu Magdalena Alonso-Galicia, PhD (Liaison with Industry Committee Representative to APS) Merck Research Labs West Point, PA 19486 Phone: 215-652-4778 Fax: 215-662-3811 E-mail: Magdalena_alonsogalicia@merck.com J. Thomas Cunningham, PhD (At-Large Councilor) University of Texas Health Sciences Center San Antonio, TX 78229 Phone: 210-567-4188 Fax: 210-567-4303 E-mail: cunninghamt@uthscsa.edu

Carolyn Ecelbarger, PhD (At-Large Councilor) Georgetown University Washington, DC Phone: 202-687-0653 E-mail: ecelbarc@georgetown.edu David Mattson, PhD (At-Large Councilor) Medical College of Wisconsin Milwaukee, WI 53226 Phone: 414-456-8265 Fax: 414-456-6546 E-mail: dmattson@mcw.edu Joey P. Granger, PhD (Past Chair) University of Mississippi Medical Center Jackson, MS 39216-4505 Phone: 601-984-1820 Fax: 601-984-1817 E-mail: jgranger@physiology.umsmed.edu Peter Bie, PhD (International Representative) University of Southern Denmark Odense C DK-5000 Denmark Phone: 45 65503799 Fax: 45 66133479 Email: pbie@health.sdu.dk Michael Humphreys, MD (Translational Physiology Representative) Univ California San Francisco San Francisco, CA 94110 Phone: 415-476-4104 Fax: 415-282-8182 Email: mhhsfgh@itsa.ucsf.edu Curt M. Sigmund, PhD (Councilor and ex officio member, AJP: Regulatory, Integrative and Comparative Physiology Editor) University of Iowa Iowa City, IA 52242 Phone: 319-335-7604 Fax: 319-353-5350 E-mail: curt-sigmund@uiowa.edu