The Approved List of biological agents - University of the ... · email: [email protected]. WHAT HAS CHANGED IN THIS EDITION? ... The classification is now entitled

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Advisory Committee on Dangerous Pathogens

The Approved List of biological agents

© Crown copyright 2004

Applications for reproduction should be made to:

Copyright Unit, Her Majesty’s Stationery Office,

St Clements House, 2-16 Colegate, Norwich NR3 1BQ

First published 2004

All rights reserved. No part of this publication may be reproduced, stored in a

retrieval system, or transmitted in any form or by any means (electronic,

mechanical, photocopying, recording or otherwise) without the prior written

permission of the copyright owner.

The classification of biological agents in this publication has a special legal status as it is approved by the Health and Safety Commission. The Control ofSubstances Hazardous to Health Regulations 2002 imposes requirements byreference to this classification which are therefore legally binding. Thus, if theclassification applies to your work activities, health and safety inspectors willexpect you to be complying with these requirements, and will, if necessary,take appropriate enforcement action.

The remainder of this publication is guidance prepared in consultation with theHealth and Safety Executive, by the Advisory Committee on DangerousPathogens (ACDP), which was appointed by the Health and SafetyCommission as part of its formal advisory structure and by Health Ministers.The guidance represents what is considered to be good practice by membersof the Committee. It has been agreed by the Commission and HealthMinisters. Following the guidance is not compulsory and you are free to takeother action, but if you do follow it you will normally be doing enough to complywith the law. Health and safety inspectors seek to secure compliance with thelaw and may refer to this guidance as illustrating good practice.

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. . .Page ii The Approved List of biological agents

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. . .Page iii The Approved List of biological agents

CONTENTS

Notice of approval ivIntroduction 1Review of list 2The Approved List 3Further information 4Annex 1:

Biological agents which may be used at less than minimum containment conditions required by COSHH 16

Guidance that should be consulted, as appropriate, when deciding oncontainment measures 17

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. . .Page iv The Approved List of biological agents

APPROVED LIST OF BIOLOGICAL AGENTS

NOTICE OF APPROVAL

The Health and Safety Commission has on 10 February 2004 approved the publication of this document, The Approved List of biological agents, for thepurposes of the Control of Substances Hazardous to Health Regulations 2002 (SI 2002/2677).

This edition of the Approved List shall have effect from 30 April 2004.

On that date the previous edition of the list (contained in the second supplement to the Categorisation of biological agents according to hazard andcategories of containment, 2000) approved by the Health and SafetyCommission on the 7 December 1999 shall cease to have effect.

Signed

MARK DEMPSEY

Secretary to the Health and Safety Commission

2 March 2004

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. . .Page 1 The Approved List of biological agents

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INTRODUCTION

1 The classification of biological agents in this document is an ApprovedList made under Section 15 of the Health and Safety at Work etc Act 1974.The Control of Substances Hazardous to Health Regulations 2002 (COSHH),by making reference to this list, impose requirements which are legally binding. The Notice of Approval signed by the Secretary to the Health andSafety Commission signals its legal status. The list implements theCommunity Classification of biological agents set out in European CommunityDirective 2000/54/EC.1

2 COSHH, at Schedule 3 paragraph 3(4)(b), states that the minimum containment level for activities which involve working with a Group 3 biologicalagent is level 3. However, those intending to work with certain Group 3 agentsmay not necessarily need to use all the containment measures normallyrequired at Containment Level 3, because of the nature of the agent and/or thenature of the work that is being carried out. The agents to which this appliesare shown in Annex 1 to the Approved List.

3 Appendix 2 to the General COSHH ACOP sets out the general approachthat should be taken when deciding which measures may not be required, butthere is also specific HSC/ACDP guidance on the agents in the Annex whichshould be consulted.

4 Genetically modified biological agents do not appear as such in theApproved List although the wild type species from which many of them arederived are listed, if they are capable of causing infection in otherwise healthyindividuals. Guidance on aspects of work with genetically modified micro-organisms is given in A guide to the Genetically Modified Organisms(Contained Use) Regulations 2000.

5 Enquiries relating to the Approved List may be addressed to the ACDPSecretariat at HSE, Rose Court, 2 Southwark Bridge, London SE1 9HS or viaemail: [email protected].

WHAT HAS CHANGED IN THIS EDITION?

6 This edition of the Approved List represents the fourth update of the official classification since it was first published in the Categorisation of biological agents according to hazard and categories of containment in 1995.

7 Changes to this edition include:● A new title and a standalone publication - previous editions of the

classification had the same title as the guidance published by the ACDP.The classification is now entitled The Approved List of biological agentsand is a standalone publication that should be read in conjunction withCOSHH and relevant ACDP guidance (see Further information).

● Reclassification, removal and addition of agents following a review byACDP and external consultation (see paragraphs 8-9).

1 OJ L 262 17 10 2000 p21

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● Removal of the exemption certificate following changes to the biologicalagents provisions of COSHH.

● Removal of Appendix 24 – the advice on work with Hazard Group 3enteric pathogens remains current but will appear in new ACDP guidance.In the interim, it will only be available on the HSE website.

REVIEW OF LIST

8 From time to time ACDP, in consultation with other experts, are asked toreview the list, in particular considering evidence for the addition of new agentsand reviewing the evidence for the classification of agents already listed.

9 As a result of the most recent consultation, a number of specificchanges have been made to the list as follows:

● Duvenhage virus has been reclassified from a Hazard Group 2 to HazardGroup 3 agent based on its similarity to rabies virus.

● Mobala virus has been reclassified from a Hazard Group 2 to HazardGroup 3 agent because of its relationship to other HG3 and HG4 are-naviruses.

● Transfusion transmitted virus, Mycobacterium avium/intracellulare, M.kansasii, M. scrofulaceum, M. simiae and M. xenopi have been reclassi-fied from Hazard Group 3 to Hazard Group 2 on the basis of current infor-mation about their infectivity.

● A number of Hazard Group 2 bacteria have been removed from the list onthe basis that they are opportunist pathogens and are usually associatedwith illness in immunocompromised individuals. As such, this means thatthey do not strictly fit the definition of a Hazard Group 2 agent. However,removal from the list does not imply that the agents are without risk. Anywork with these agents must be subject to risk assessment underCOSHH, the same as work with any other biological agent, and appropriate containment and control measures put in place. In addition,the assessment would need to identify any individuals who may be more vulnerable to infection, for example because they are immunocompromised.

● Uukuviruses have been removed from the list as the agents have notbeen associated with human disease.

● Trypanosoma rangeli has been removed from the list as the agent doesnot cause human disease.

● A new agent, human metapneumonovirus, has been added in HazardGroup 2.

● A new agent, the causative agent of Severe Acute Respiratory Syndrome(SARS) has been added in Hazard Group 3.

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THE APPROVED LIST

10 The Approved List of biological agents should be read in conjunctionwith COSHH 2002 and, in particular, Schedule 3 – Additional provisions relating to work with biological agents.

11 Agents appearing in the Approved List are classified on the basis of theirability to cause disease by infection. Only agents in Groups 2, 3 and 4 are listed. Those not listed in these groups are not implicitly classified in Group 1.

12 In allocating agents to a Hazard Group, no account is taken of particulareffects on those whose susceptibility to infection may be affected, for examplebecause of pre-existing disease, medication, compromised immunity, pregnancy or breast-feeding. Any additional risks to such employees shouldbe considered as part of the general risk assessment required by COSHH2002. In the case of new or expectant mothers, assessment of infection risksis required by the Management of Health and Safety at Work Regulations1999.

13 If more than one species in any particular genus is known to be pathogenic to humans, the most prominent of these is generally named. Theremay also be a wider reference (‘spp’) which indicates that other species of thesame genus may be hazardous. However, if a whole genus is indicated in thisway, it is implicit that species and strains that are non-pathogenic to humansare excluded.

14 Where a biological agent has an approved classification but is considered to present a different risk of infection from the agent listed, forexample because it has lost known virulence genes, then the agent should bereclassified and appropriate containment measures selected on the basis ofthe new classification and the assessment of the risks from the work that is tobe undertaken with the agent. This reclassification must be done in consultation with HSE in line with COSHH, Schedule 3, paragraph 2(3).

15 All viruses which have been isolated from humans, but which do nothave an approved classification, should be classified in Hazard Group 2 as aminimum, except where there is evidence that they are unlikely to cause disease in humans.

16 The containment measures required for work with parasites apply onlyto the stages in the life cycle of the parasite in which it is liable to be infectiousfor humans.

17 The Approved List also gives a separate indication of which biologicalagents are capable of causing allergic or toxic reactions or where there is aneffective vaccine available. This is shown by the following notations:

A: possible allergic effects;

T: toxin production;

V: vaccine available.

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18 There is a requirement in COSHH to keep a list of employees exposedto Hazard Group 3 or Group 4 biological agents for at least 40 years after thelast exposure (Schedule 3, paragraph 4). This requirement is extended tocover employees exposed to one Hazard Group 2 agent: Human herpes virustype 8.

FURTHER INFORMATION

The following HSE and ACDP publications give advice on various aspects ofwork with biological agents:

A guide to the Genetically Modified Organisms (Contained Use) Regulations2000 L29 ( Third edition) HSE Books 2000 ISBN 0 7176 1758 0

BSE (Bovine Spongiform Encephalopathy): Background and general occupational guidance Guidance HSE Books 1996 ISBN 0 7176 1212 0

Control of substances hazardous to health. The Control of SubstancesHazardous to Health Regulations 2002. Approved Code of Practice and guidance L5 (Fourth edition) HSE Books 2002 ISBN 0 7176 2534 6

The large-scale contained use of biological agents Guidance HSE Books 1998ISBN 0 7176 1544 8

Management and control of viral haemorrhagic fevers The Stationery Office1997 ISBN 011321860 5

The management, design and operation of microbiological containment laboratories Guidance HSE Books 2001 ISBN 0 7176 2034 4

Protection against blood-borne infections in the workplace: HIV and hepatitisThe Stationery Office 1995 ISBN 0 11321953 9

Transmissible spongiform encephalopathies: Safe working and the preventionof infection Internet only 2003 www.advisorybodies.doh.gov.uk/acdp/tseguidance/index.htm

Working safely with research animals: Management of infection risks GuidanceHSE Books 1997 ISBN 0 7176 1377 1

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Biological agent Classification Notes

BACTERIA

Actinobacillus actinomycetemcomitans 2Actinomadura madurae 2Actinomadura pelletieri 2Actinomyces gerencseriae 2Actinomyces israelii 2Actinomyces pyogenes 2Actinomyces spp 2Alcaligenes spp 2Arcanobacterium haemolyticum (Corynebacterium haemolyticum) 2

Bacillus anthracis 3 VBacillus cereus 2Bacteroides fragilis 2Bacteroides spp 2Bartonella bacilliformis 2Bartonella quintana (Rochalimaea quintana) 2Bartonella spp (Rochalimaea spp) 2Bordetella bronchiseptica 2Bordetella parapertussis 2Bordetella pertussis 2 VBorrelia burgdorferi 2Borrelia duttonii 2Borrelia recurrentis 2Borrelia spp 2Brucella abortus 3Brucella canis 3Brucella melitensis 3Brucella suis 3Burkholderia cepacia 2Burkholderia mallei (Pseudomonas mallei) 3Burkholderia pseudomallei(Pseudomonas pseudomallei) 3

Campylobacter fetus 2Campylobacter jejuni 2Campylobacter spp 2Cardiobacterium hominis 2Chlamydia pneumoniae 2Chlamydia psittaci (non avian strains) 2Chlamydia psittaci (avian strains) 3Chlamydia trachomatis 2Clostridium botulinum 2 T, VClostridium perfringens 2Clostridium tetani 2 T, VClostridium spp 2Corynebacterium diphtheriae 2 T, VCorynebacterium minutissimum 2Corynebacterium pseudotuberculosis 2

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Corynebacterium spp 2Coxiella burnetii 3Edwardsiella tarda 2Ehrlichia sennetsu (Rickettsia sennetsu) 3Ehrlichia spp 2Eikenella corrodens 2Enterobacter aerogenes/cloacae 2Enterobacter spp 2Enterococcus spp 2Erysipelothrix rhusiopathiae 2Escherichia coli (with the exception of

non-pathogenic strains) 2Escherichia coli, verocytotoxigenic strains

(eg O157:H7 or O103) 3 TFlavobacterium meningosepticum 2Fluoribacter bozemanae (formerly Legionella) 2Francisella tularensis (Type A) 3 VFrancisella tularensis (Type B) 2Fusobacterium necrophorum 2Fusobacterium spp 2Gardnerella vaginalis 2Haemophilus ducreyi 2Haemophilus influenzae 2Haemophilus spp 2Helicobacter pylori 2Klebsiella oxytoca 2Klebsiella pneumoniae 2Klebsiella spp 2Legionella pneumophila 2Legionella spp 2Leptospira interrogans (all serovars) 2Listeria ivanovii 2Listeria monocytogenes 2Moraxella catarrhalis 2Morganella morganii 2Mycobacterium africanum 3 VMycobacterium avium/intracellulare 2Mycobacterium bovis (BCG strain) 2Mycobacterium bovis 3 VMycobacterium chelonae 2Mycobacterium fortuitum 2Mycobacterium kansasii 2Mycobacterium leprae 3 VMycobacterium malmoense 3Mycobacterium marinum 2Mycobacterium microti 3Mycobacterium paratuberculosis 2Mycobacterium scrofulaceum 2Mycobacterium simiae 2

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Mycobacterium szulgai 3Mycobacterium tuberculosis 3 VMycobacterium ulcerans 3Mycobacterium xenopi 2Mycoplasma caviae 2Mycoplasma hominis 2Mycoplasma pneumoniae 2Neisseria gonorrhoeae 2Neisseria meningitidis 2 VNocardia asteroides 2Nocardia brasiliensis 2Nocardia farcinica 2Nocardia nova 2Nocardia otitidiscaviarum 2Pasteurella multocida 2Pasteurella spp 2Peptostreptococcus anaerobius 2Peptostreptococcus spp 2Plesiomonas shigelloides 2Porphyromonas spp 2Prevotella spp 2Proteus mirabilis 2Proteus penneri 2Proteus vulgaris 2Providencia alcalifaciens 2Providencia rettgeri 2Providencia spp 2Pseudomonas aeruginosa 2Pseudomonas mallei

- see Burkholderia mallei 3Pseudomonas pseudomallei

- see Burkholderia pseudomallei 3Rhodococcus equi 2Rickettsia akari 3Rickettsia canada 3Rickettsia conorii 3Rickettsia montana 3Rickettsia prowazekii 3Rickettsia rickettsii 3Rickettsia tsutsugamushi 3Rickettsia sennetsu

- see Ehrlichia sennetsu 3Rickettsia typhi (Rickettsia mooseri) 3Rickettsia spp 3Rochalimaea quintana

- see Bartonella quintana 2Rochalimaea spp 2Salmonella arizonae 2Salmonella enteritidis 2

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Salmonella (other serovars) 2Salmonella paratyphi A,B,C 3Salmonella typhi 3 VSalmonella typhimurium 2Serpulina spp 2Shigella boydii 2Shigella dysenteriae (Type 1) 3 TShigella dysenteriae (other than Type 1) 2Shigella flexneri 2Shigella sonnei 2Staphylococcus aureus 2 TStreptobacillus moniliformis 2Streptococcus pneumoniae 2Streptococcus pyogenes 2Streptococcus suis 2Streptococcus spp 2Treponema carateum 2Treponema pallidum 2Treponema pertenue 2Treponema spp 2Ureaplasma urealyticum 2Vibrio cholerae (including El Tor) 2 T, VVibrio parahaemolyticus 2Vibrio spp 2Yersinia enterocolitica 2Yersinia pestis 3 VYersinia pseudotuberculosis 2Yersinia spp 2

VIRUSES

ADENOVIRIDAE 2ARENAVIRIDAELCM-Lassa-virus complex

(Old World arenaviruses):Ippy 2Lassa fever 4Lymphocytic choriomeningitis 3Mobala 3Mopeia 3Other LCM-Lassa complex viruses 2

Tacaribe-virus-complex (New World arenaviruses):

Amapari 2Flexal 3Guanarito 4Junin 4Latino 2Machupo 4

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Parana 2Pichinde 2Sabia 4Tamiami 2

ASTROVIRIDAE 2BORNAVIRIDAEBorna disease virus 3BUNYAVIRIDAEAkabane 3Bunyamwera 2California encephalitis 2Germiston 3Oropouche 3Hantaviruses:

Belgrade (Dobrava) 3Hantaan (Korean haemorrhagic fever) 3Prospect Hill 2Puumala 2Seoul 3Sin Nombre (formerly Muerto Canyon) 3Other Hantaviruses 2

Nairoviruses:Bhanja 3Crimean/Congo haemorrhagic fever 4Hazara 2

Phleboviruses:Rift valley fever 3 VSandfly fever 2Toscana 2Other Bunyaviridae known to be

pathogenic 2CALICIVIRIDAEHepatitis E 3Norwalk 2Other Caliciviridae 2CORONAVIRIDAE 2

SARS 3FILOVIRIDAEEbola Reston 4Ebola Siena 4Ebola Sudan 4Ebola Zaire 4Marburg 4FLAVIVIRIDAEFlaviviruses:

Dengue viruses types 1-4 3Hepatitis G 3Israel turkey meningitis 3Japanese B encephalitis 3 V

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Murray Valley encephalitis 3Rocio 3Sal Vieja 3San Perlita 3Spondweni 3St Louis encephalitis 3Wesselsbron 3West Nile fever 3Yellow fever 3 V

Tick-borne virus group:Absettarov 3 VHanzalova 3 VHypr 3 VKumlinge 3Kyasanur forest disease 4 VLouping ill 3 VNegishi 3Omsk 4 VPowassan 3Russian spring summer encephalitis 4 V

Hepatitis C group viruses:Hepatitis C 3

Other flaviviruses known to be pathogenic 2HEPADNAVIRIDAEHepatitis B 3 VHepatitis D (delta) 3 VHERPESVIRIDAECytomegalovirus 2Epstein-Barr virus 2Herpes simplex types 1 and 2 2Herpes virus varicella-zoster 2Herpesvirus simiae (B virus) 4Human herpesvirus type 6 - HHV6 2Human herpesvirus type 7 - HHV7 2Human herpesvirus type 8 - HHV8 2ORTHOMYXOVIRIDAEInfluenza types A, B and C 2 VTick-borne orthomyxoviridae:

Dhori and Thogoto 2PAPOVAVIRIDAE BK and JC viruses 2Human papillomaviruses 2Simian virus 40 (SV40) 2PARAMYXOVIRIDAEHendra (formerly equine morbillivirus) 4Human metapneumonovirus 2Measles 2 VMumps 2 VNewcastle disease 2

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Nipah 4Parainfluenza (Types 1 to 4) 2Respiratory syncytial virus 2PARVOVIRIDAEHuman parvovirus (B19) 2PICORNAVIRIDAEAcute haemorrhagic conjunctivitis virus (AHC) 2Coxsackieviruses 2Echoviruses 2Polioviruses 2 VRhinoviruses 2Hepatoviruses:

Hepatitis A (human enterovirus type 72) 2 VPOXVIRIDAEBuffalopox 2Cowpox2 2Milker’s nodes 2Molluscum contagiosum 2Monkeypox 3 VOrf 2Vaccinia3 2Variola (major and minor)4 4 VYatapox (Tana and Yaba) 2REOVIRIDAEColtivirus 2Human rotaviruses 2Orbiviruses 2Reoviruses 2RETROVIRIDAEHuman immunodeficiency viruses 3Human T-cell lymphotropic viruses (HTLV)

types 1 and 2 3Simian immunodeficiency virus 3RHABDOVIRIDAE Duvenhage 3 VPiry 3Rabies 3 VVesicular stomatitis 2TOGAVIRIDAEAlphaviruses:

Bebaru 2Chikungunya 3Eastern equine encephalomyelitis 3Everglades 3Getah 3

2 Including strains isolated from domestic cats and captive exotic species, eg elephants, cheetahs.3 Including strains originally classified as rabbitpox.4 All strains including whitepox virus.

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Mayaro 3Middleburg 3Mucambo 3Ndumu 3O’nyong-nyong 2Ross river 2Sagiyama 3Semliki forest 2Sindbis 2Tonate 3Venezuelan equine encephalomyelitis 3Western equine encephalomyelitis 3 VOther known alphaviruses 2

Rubiviruses:Rubella 2 V

TOROVIRIDAE 2UNCLASSIFIED VIRUSESHepatitis viruses not yet identified 3Transfusion transmitted virus 2UNCONVENTIONAL AGENTS ASSOCIATED WITH THE TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES (TSES):

Bovine spongiform encephalopathy (BSE) and other related animal TSEs 3

Creutzfeldt-Jakob disease 3Variant Creutzfeldt-Jakob disease 3Fatal familial insomnia 3Gerstmann-Sträussler-Scheinker syndrome 3Kuru 3

PARASITES

Acanthamoeba castellanii 2Acanthamoeba spp 2Ancylostoma duodenale 2Angiostrongylus cantonensis 2Angiostrongylus costaricensis 2Anisakis simplex 2Ascaris lumbricoides 2 AAscaris suum 2 ABabesia divergens 2Babesia microti 2Balantidium coli 2Blastocystis hominis 2Brugia malayi 2Brugia pahangi 2Brugia timori 2Capillaria philippinensis 2Capillaria spp 2

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Clonorchis - see OpisthorchisContracaecum osculatum 2Cryptosporidium parvum 2Cryptosporidium spp 2Cyclospora cayetanensis 2Cyclospora spp 2Dicrocoelium dendriticum 2Dientamoeba fragilis 2Dipetalonema - see Mansonella 2Diphyllobothrium latum 2Dracunculus medinensis 2Echinococcus granulosus 3Echinococcus multilocularis 3Echinococcus vogeli 3Entamoeba histolytica 2Enterobius vermicularis 2Enterocytozoon bieneusi 2Fasciola gigantica 2Fasciola hepatica 2Fasciolopsis buski 2Giardia lamblia (Giardia intestinalis) 2Heterophyes spp 2Hymenolepis diminuta 2Hymenolepis nana 2Isopora belli 2Leishmania aethiopica 2Leishmania brasiliensis 3Leishmania donovani 3Leishmania mexicana 2Leishmania peruviana 2Leishmania major 2Leishmania tropica 2Leishmania spp 2Loa loa 2Mansonella ozzardi 2Mansonella perstans 2Mansonella streptocerca 2Metagonimus spp 2Naegleria fowleri 3Necator americanus 2Onchocerca volvulus 2Opisthorchis felineus 2Opisthorchis sinensis (Clonorchis sinensis) 2Opisthorchis viverrini (Clonorchis viverrini) 2Opisthorchis spp 2Paragonimus westermani 2Paragonimus spp 2Plasmodium falciparum 3Plasmodium spp (human & simian) 2

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Pseudoterranova decipiens 2Sarcocystis suihominis 2Schistosoma haematobium 2Schistosoma intercalatum 2Schistosoma japonicum 2Schistosoma mansoni 2Schistosoma mekongi 2Schistosoma spp 2Strongyloides stercoralis 2Strongyloides spp 2Taenia saginata 2Taenia solium 3Toxocara canis 2Toxocara cati 2Toxoplasma gondii 2Trichinella nativa 2Trichinella nelsoni 2Trichinella pseudospiralis 2Trichinella spiralis 2Trichomonas vaginalis 2Trichostrongylus orientalis 2Trichostrongylus spp 2Trichuris trichiura 2Trypanosoma brucei brucei 2Trypanosoma brucei gambiense 2Trypanosoma brucei rhodesiense 3Trypanosoma cruzi 3Wuchereria bancrofti 2

FUNGI

Aspergillus fumigatus 2 ABlastomyces dermatitidis

(Ajellomyces dermatitidis) 3Candida albicans 2 ACandida tropicalis 2Candida spp 2Cladophialophora bantiana (formerly

Xylohypha bantiana, Cladosporium bantianum) 3Coccidioides immitis 3 ACryptococcus neoformans var neoformans(Filobasidiella neoformans var neoformans) 2 ACryptococcus neoformans var gattii

(Filobasidiella bacillispora) 2 AEmmonsia parva var parva 2Emmonsia parva var crescens 2Epidermophyton floccosum 2 AFonsecaea compacta 2Fonsecaea pedrosoi 2

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Histoplasma capsulatum var capsulatum

(Ajellomyces capsulatus) 3Histoplasma capsulatum var duboisii 3Histoplasma capsulatum var farcinimosum 3Madurella grisea 2Madurella mycetomatis 2Microsporum spp 2 ANeotestudina rosatii 2Paracoccidioides brasiliensis 3Penicillium marneffei 3 AScedosporium apiospermum

(Pseudallescheria boydii) 2Scedosporium proliferans (inflatum) 2Sporothrix schenckii 2Trichophyton rubrum 2Trichophyton spp 2

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ANNEX 1 BIOLOGICAL AGENTS WHICH MAY BE USED AT LESS THANMINIMUM CONTAINMENT CONDITIONS REQUIRED BY COSHH

Although COSHH sets out the minimum containment requirements that mustbe applied in particular circumstances (Schedule 3 4(a-f)), there are certain circumstances when not all the measures normally required at a particular containment level need be applied because of either:

● the nature of the work; or

● the nature of the biological agent.

This approach can be taken when working with the specified HG3 agentsbelow. COSHH enables you to do this provided that you follow the guidanceon selecting the most appropriate containment measures that is set out in thepublications listed on page 17.

Dispensing with containment measures is not an automatic right and any decision to change the containment conditions should only be taken after carrying out a local risk assessment.

Bacteria1 Escherichia coli, vero-cytotoxigenic strains (eg O157:H7 or O103)2 Mycobacterium microti3 Mycobacterium ulcerans4 Salmonella typhi5 Salmonella paratyphi6 Shigella dysenteriae (Type 1)

Viruses7 Hepatitis B virus8 Hepatitis C virus9 Hepatitis D virus10 Hepatitis E virus11 Hepatitis G virus12 Human immunodeficiency viruses13 Human T-cell lymphotropic viruses14 Hepatitis viruses not yet identified15 The agent of bovine spongiform encephalopathy (BSE) and other

related animal TSEs16 The agent of Creutzfeldt-Jakob disease17 The agent of variant Creutzfeldt-Jakob disease18 The agent of fatal familial insomnia19 The agent of Gerstmann-Sträussler-Scheinker syndrome20 The agent of Kuru21 Simian immunodeficiency virus

Parasites22 Echinococcus granulosus23 Echinococcus multilocularis24 Echinococcus vogeli25 Leishmania braziliensis

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26 Leishmania donovani27 Plasmodium falciparum28 Taenia solium29 Trypanosoma brucei rhodesiense

GUIDANCE THAT SHOULD BE CONSULTED, AS APPROPRIATE, WHENDECIDING ON CONTAINMENT MEASURES

Advisory Committee on Dangerous Pathogens Transmissible spongiformencephalopathies: Safe working and the prevention of infection Internet only2003 www.advisorybodies.doh.gov.uk/acdp/tseguidance/index.htm

Protection against blood-borne infections in the workplace: HIV and hepatitisThe Stationery Office 1995 ISBN 0 11321953 9

Advisory Committee on Dangerous Pathogens Guidance on work with HazardGroup 3 enteric pathogens Internet only www.hse.gov.uk/ecoli.htm

For technical advice on selecting the most appropriate containment measurescontact HSE’s Biological Agents Unit (Tel: 0151 951 4000)

Documents

The Approved List of biological agents - University of the ... · email: [email protected]. WHAT HAS CHANGED IN THIS EDITION? ... The classification is now entitled