The Evolution of Ion Mobility MS - waters.com · ©2015 Waters Corporation 6 2001 Linear Field IMS 2003 First T-Wave IMS 2004 Prototype SYNAPT Q-IMS-Tof 2006 SynaptHDMS TriWave, DriftScope

©2015 Waters Corporation 1

The Evolution of Ion Mobility MS


2001 Linear Field IMS


Gate

MobilityRegion

StorageRegion Quadrupole

Mass Filter

ElectrosprayTip

Pusher

Detector

Reflectron

LensesCollision

Cell

SecondTransferRegion

Electric Field

FirstTransfer Region

Stacked RingIon Guide

Ions



2003 First T-Wave IMS

2004 Prototype SYNAPT Q-IMS-Tof






2006 Synapt HDMS TriWave, DriftScope



The Challenge of Ion Mobility



2007 MALDI Synapt




2009 Synapt G2 HDMS 2nd Gen TriWave & QuanTOF




2007 MALDI Synapt


2010 MALDI Synapt G2 HDMS HDI Software, ETD




2011 Synapt G2S HDMS StepWave




2007 MALDI Synapt







2013 Synapt G2Si HDMS Enhancing Workflows (implementing CCS) Dedicated IMS Apps Software (UNIFITM), MS Compare, IntellistartTM


CCS

Structure Separation

Sensitivity Specificity


Opportunity

Measure CCS of every ion in every

analysis Incorporate CCS into routine workflows



2007 MALDI Synapt







2013 Synapt G2Si HDMS Enhancing Workflows (implementing CCS) Dedicated IMS Apps Software (UNIFITM), MS Compare, IntellistartTM

2015 Accessible Ion Mobility


Beyond Resolution



Dual Channel 7.2GHz (up-sampled) 10-bit ADC

QuanTof2 Detector

x 1

x 0.03

ADC High Gain Channel

ADC Low Gain Channel

Peak Processing

Peak processing

ADC Test signal

Apply calibration

Combine From MS

ADC Amplifier


Benefits of QuanTof2


UN

IFI

Streamlined Instrument Controls

Seamless Workflows

Integrated Ion Mobility Tools Sophisticated Reporting

UNIFI: Taking Data to Knowledge

UNIFI 1.8


Routine ion mobility

• Just press START

• Simply Acquire

• Get to the Answers

Seamlessly from sample to answers


Clarity cleaner mass spectra

Confidence valuable CCS information for

every ion

System Productivity with UNIFI analytical

workflows

Benefits of Routine Ion Mobility


518.2235 m/z

441.2758 m/z

289.1923 m/z

617.3076 m/z 236.6 Å2 Verapamil- CH2 + C6H8O6

Benefits of Routine Ion Mobility Ion Mobility Off


518.2235 m/z

441.2758 m/z

289.1923 m/z

617.3076 m/z 236.6 Å2 Verapamil - CH2 + C6H8O6

Clarity

Unlimited Product ion

HDMSE

Benefits of Routine Ion Mobility Ion Mobility On


Vion measured CCS(N2) values

Reserpine - 609.28 m/z : 252 Å2 - 0.10 % RSD

LueEnk – 556.27 m/z : 230 Å2 - 0.15 % RSD

Terfenadine – 472.32 m/z : 230 Å2 - 0.12 % RSD

Verapamil – 455.29 m/z : 211 Å2 - 0.17 % RSD

Sulphadimethoxine – 311.08 m/z : 168 Å2 - 0.15 % RSD

Caffine – 195.08 m/z : 136 Å2 - 0.22 % RSD

Data from 400 injections over 33 hours

<2% time after time


-5

-4

-3

-2

-1

0

1

2

3

4

5

Ace

tam

ipri

d

Azo

xyst

rob

in

Bro

mu

con

azo

leII

Car

be

tam

ide

Car

bo

fura

n

Ch

lorb

rom

uro

n

Ch

lori

daz

on

(Pyr

azo

n)

Cle

tho

dim

I

Cle

tho

dim

Ifgt

Cle

tho

dim

II

Cle

tho

dim

IIfg

t

Cyr

om

azin

e

DEE

T

De

me

ton

-S-m

eth

yl-s

ulf

on

e

Dic

hlo

rvo

s

Die

tho

fen

carb

fgt

Dis

ulf

oto

n-s

ulf

on

e

Diu

ron

Eth

op

rop

ho

s

Fen

amip

ho

ssu

lph

on

e

Fen

oxy

carb

Fen

oxy

carb

fgt

Fen

pro

pim

orp

h

Fen

pyr

oxi

mat

Flu

tria

fol

Form

eta

nat

e

Fost

hia

zate

Fura

thio

carb

He

pte

no

ph

os

He

xazi

no

ne

Ind

oxa

carb

Iso

xab

en

Lin

uro

n

Me

sotr

ion

e

Me

tala

xyl

Me

thab

en

zth

iazu

ron

Me

tob

rom

uro

n

Me

tola

chlo

r

Me

trib

uzi

n

Me

vin

ph

os

tran

s

Nit

en

pyr

am

Oxa

dia

zon

pe

tho

xam

id

ph

en

tho

ate

Pir

imic

arb

Pri

mic

arb

-de

sme

thyl

fgt*

Pro

pam

oca

rb

pro

par

gite

Pro

sulf

oca

rb

Pym

etr

ozi

ne

Pyr

aclo

stro

bin

Pyr

idab

en

Pyr

idab

en

fgt

1

Pyr

idat

e

Pyr

ipro

xife

n

Sim

azin

e

Spin

osa

d

Spir

od

iclo

fen

Spir

oxa

min

eII

Teb

uco

naz

ole

tep

ralo

xyd

im

Thia

clo

pri

d

Thio

dic

arb

Thio

ph

anat

e-m

eth

yl

Tria

sulf

uro

n

Trif

lum

uro

n

Trin

exa

pac

-eth

yl

Trit

ico

naz

ole

Vam

ido

thio

n

% C

CS

Dif

fere

nce

Axis Title

Synapt WIV ISP/Vion IMS Q ToF Comparison April 2015

Pesticide

WIV ISP Study: SYNAPT/Vion Comparison for Pesticides

Dr Severine Goscinny, Scientific Institute of Public Health, Belgium Coming soon...

Confidence


Confidence

Benefits of Routine Ion Mobility


153 Coeluting Components Resolved with Vion Mobility

System Productivity



Vion IMS QTof presentations this week


Experience the best of ASMS with Waters


Presentation at ASMS highlighting Waters IMS enabled technology

Waters Presentations at ASMS

– All

o 17 Orals

o 102 Posters

– Including IMS enabled technology

o 8 Orals (47%)

o 27 Posters (26%)


Ion-Mobility at ASMS

0

1000

2000

3000

4000

5000

6000

7000

0

500

1000

1500

2000

2500

3000

3500

4000

2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014

Tota

l Att

en

dan

ce

nu

mb

er o

f ASM

S ab

stra

cts

Year

total abstracts

attendance

0

1000

2000

3000

4000

5000

6000

7000

0

50

100

150

200

250

300

350

400

2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014

Tota

l Att

en

dan

ce

nu

mb

er o

f ASM

S ab

stra

cts

Year

"IMS" or "mobility" in abstract

attendance


Ion-Mobility at ASMS

0

1000

2000

3000

4000

5000

6000

7000

0

50

100

150

200

250

300

350

400

2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014

Tota

l Att

en

dan

ce

nu

mb

er o

f ASM

S ab

stra

cts

Year

"IMS" or "mobility" in abstract

attendance

Year Total AbstractsAbstracts containing

"IMS" or "mobility"

% containing "IMS"

or "mobility"

2000 1619 30 1.9

2007 2872 127 4.4

2014 3541 348 9.8

Introduction of first commercial IMS system (SYNAPT HDMS)


Presentation at ASMS highlighting Waters IMS enabled technology

Session Type Location Time Title Presenters Affiliations

Quantitative Analysis in Drug

Discovery for Small MoleculesOral Ballroom 220/221 4:10pm - 4:30pm Comparison of travelling wave IMS-QTof geometries and acquisition modes for quantitative analysis

M ark Wrona* (1) ; Yun Alelyunas(1) ; Jayne Kirk(2) ; M artin Palmer(2)

; Nick Tomczyk(2) ; Russell M ortishire-Smith(2)

(1) Waters Corporation, M ilford, M A; (2) Waters M S Technologies,

Wilmslow, United Kingdom

Advances in Software and Hardware

to Improve DMPK WorkflowsOral Ballroom 220/221 9:10am - 9:30am Fully integrated novel IMS-QTof informatics platform for rapid drug screening and elucidation

Russell M ortishire-Smith* (1) ; Jayne Kirk(1) ; Nick Tomczyk(1) ;

M artin Palmer(1) ; Richard Denny(1) ; A lan Prile(1) ; Simon

Cubbon(1) ; Yun Alelyunas(2) ; M ark Wrona(2)

(1) Waters M S Technologies, Wilmslow, United Kingdom; (2) Waters

Corporation, M ilford, M A

Energy, Petroleum, & Biofuels:

Advances in MS Design & InformaticsOral Ballroom 222/224 8:30am - 8:50am

Comparison of atmospheric solid analysis probe with other atmospheric pressure ionization sources by

ion mobility-mass spectrometry using PetroOrg software

M athilde Farenc* (1, 5) ; Yuri E. Corilo(2, 3) ; Priscila M . Lalli(3) ;

Eleanor Riches(4) ; Ryan P. Rodgers(2) ; Carlos Afonso(1) ; P ierre

Giusti(5

(1) University o f Rouen, M ont Saint A ignan, France; (2) National

High M agnetic Field Laboratory, Tallahassee, FL; (3) Future Fuels

Institute, Tallahassee, FL; (4) Waters Corporation, Wilmslow, UK; (5)

TOTAL Refining and Chemicals, Gonfreville l'Orcher, France

Energy, Petroleum, & Biofuels:

Advances in MS Design & InformaticsOral Ballroom 222/224 9:50am - 10:10am Algae Biomass Characterization by Traveling Wave Ion Mobility Mass Spectrometry

M aira Fasciotti* (1) ; Ingrid Chastinet Ribeiro(1) ; Paulo Roque

M artins Silva(1) ; Thays V. M onteiro(1) ; Gustavo H. M . F. Souza(2) ;

Julia Itaco lomy da Silva(1) ; Romeu J. Daroda(1) ; Valnei S. Cunha(1)

; Claudia M aria Luz Lapa Teixeira(3) ; Amarjit S. Sarpal(1)

(1) Inmetro, Duque De Caxias, Brazil; (2) Waters Coorporation, Rio

de Janeiro, Brazil; (3) National Institute of Technology, INT, Rio de

Janeiro, Brazil

Poster Poster Poster 239 - Natural ProductsUtilization of a Novel Geometry Travelling Wave IMS/Q-TOF Mass Spectrometer for Natural Products

Profiling

Anthony T. Iavarone(1) ; Ulla N. Andersen(1) ; Darren Hewitt(2) ;

Andrew Baker* (3)

(1) UC Berkeley, Berkeley, CA; (2) Waters, Wilmslow, UK; (3) Waters,

Inc., P leasanton, CA

Poster PosterPoster 133 - Ion Mobility:

Theory

Comparison of CCS(N2) measurements obtained from two different T-wave IMS systems with direct

measurements using a drift tube IMSKevin Giles; M artin Palmer; Keith Richardson; Nick Tomczyk* Waters M S Technologies, Wilmslow, United Kingdom

Poster Poster

Poster 651 - Energy:

Hydrocarbon and

Petrochemical

Supercritical Fluid Chromatography Coupled with Ion Mobility-Mass Spectrometry for Comprehensive

Profiling of Petroleum SamplesEleanor Riches* (1) ; Yunju Cho(2) ; Sunghwan Kim(2)

(1) Waters Corporation, Wilmslow, United Kingdom; (2) Chemistry

Department, Kyungpook National Universit, Daegu, South Korea


InstrumentalCharacterizing a T-Wave Enabled Multi-pass Cyclic Ion Mobility Separator

Kevin Giles* ; Jason L Wildgoose; Steven Pringle; David Langridge;

Peter Nixon; John Garside; Peter CarneyWaters Corporation, Wilmslow, United Kingdom

Poster Poster

Poster 205 - Top down Protein

Analysis: Relatively Pure

Sample

Improving Protein Sequence Coverage and Identification of Oxidation Sites via Top/Middle -Down

Fragmentation and Ion-mobility Time-of-flight Mass Spectrometry

Stephane Houel(1) ; Catalin Doneanu(1) ; Asish Chakraborty* (1) ;

Andrew Tudor(2) ; Nick Tomczyk(2) ; M artin Palmer(2) ; Weibin

Chen(1)

(1) Waters Corp, M ilford, M A; (2) Waters M S Technologies,



Instrumental

Ultra-definition multiplex acquisition (UDMSE) of whey protein supplements by traveling wave ion

mobility mass spectrometry (TWIM-MS)

Gustavo H. M . F. Souza* (1) ; M aÃ-ra Fasciotti(2) ; Bruno C.

Garrido(2) ; Daniela C. LourenÃ§o(2) ; Andrea F. M acedo(3) ;

M ariana S. L. Ferreira(3) ; Luiz Claudio Cameron(3)

(1) Waters Corporation, Rio de Janeiro, Brazil; (2) INM ETRO, Duque

De Caxias, Brazil; (3) UNIRIO, Rio de Janeiro, Brazil


TheoryPredicting Theoretical Collision-cross Sections for Small Molecules

Bela Paizs* (1) ; Keith Richardson(2) ; Jeff Brown(2) ; M ike

M orris(2) ; Zo ltan Takats(3)

(1) Bangor University, Bangor, UK; (2) Waters Corporation,

Wilmslow, United Kingdom; (3) Imperial College London, London,

N/A

Instrumentation: Time-of-flight and QTOF Oral Hall 5 8:50am - 9:10am Novel operating modes of an ion mobility quadrupole time-of-flight hybrid instrument Jason L Wildgoose* ; Kevin Giles; Keith Richardson; Steven Pringle Waters Corporation, M anchester, United Kingdom

Poster Poster

Poster 123 - High Mass

Accuracy/High Performance MS:

Instrumentation

A novel method of m/z drift correction for oa-TOF mass spectrometers based on construction of libraries of 'matrix'

componentsM artin Green* ; Keith Richardson; M artin Palmer; Nick Tomczyk Waters Corporation, M anchester, UNITED KINGDOM

Poster PosterPoster 233 - Drug Metabolism:

Qualitative Analysis

Comprehensive metabolite detection by utilising both positive and negative ionization on an integrated microfluidic-

ion source with CCS measurements

Richard Gallagher* (1) ; Christine Pattison(1) ; Kathryn Pickup(1) ;

John Chipperfield(2) ; M ike M cCullagh(2) ; Jim M urphy(3) ; David

Douce(2)

(1) AstraZeneca, M acclesfield, UK; (2) Waters (M S Technologies),

Wilmslow, United Kingdom; (3) Waters, M ilford, USA

Ion Mobility: Structures Oral Room 123/124 8:50am - 9:10am Pushing the boundaries of small molecule analysis: using ion mobility MS and gas-phase infrared spectroscopy to study

protonation site isomers

Jasper Boschmans* (1) ; Stephan Warnke(2) ; Jongcheol Seo(2) ;

Jonathan P. Williams(3) ; Kevin Pagel(2, 4) ; Gert von Helden(2) ;

Filip LemiÃ¨re(1) ; Frank Sobott(1)

(1) University o f Antwerp, Antwerp, Belgium; (2) Fritz-Haber-Institut

der M ax-Planck-Gesellschaft, Berlin, Germany; (3) Waters

Corporation, M anchester, UK; (4) Freie UniversitÃ¤t Berlin, Berlin,

Germany

Poster Poster Poster 568 - Ion Mobility: StructuresInvestigation of Ion Mobility Mass Spectrometry Analysis of Electrochemically Generated Oxidation Products of Opiates

and Comparison with Theoretical CCS Values

Cris Lapthorn(1) ; Frank Pullen(1) ; Susana da Silva Torres(2) ; M ark

R. Taylor(2) ; Russell M ortishire-Smith(3) ; Jayne Kirk* (3) ; Andrew

Baker(4)

(1) University o f Greenwich, Chatham M aritime, UK; (2) Pfizer,

Sandwich, UK; (3) Waters Corp, M anchester, UK; (4) Waters, Inc.,

P leasanton, CA

Poster Poster Poster 631 - Systems Biology: Other Studies of Heart Regeneration in Zebrafish: A Multi-Omics/System Biology ApproachLeanne C. Nye* (1) ; Lee Gethings(2) ; Cheng Shuk Han(3) ; Yun Wah

Lam(3) ; Fatemeh Babaei(3) ; Chi Chi Liu(3) ; A lfred W. H. Chan(3) ;

Robert P lumb(4) ; Ian D. Wilson(1)

(1) Imperial College, London, UK; (2) Waters Corporation, Wilmslow,

UK; (3) City University, Hong Kong, Hong Kong; (4) Waters, M ilford,

M A

Poster PosterPoster 267 - Lipids: ID and Structural

Analysis

Characterization and Collision Cross Section Determination of Obesity Related Lipids Within Mouse Models Using

Travelling Wave IMS-QTof Mass Spectrometry

Gertjan Kramer(1) ; Nicholas Dekker(1) ; Lee A Gethings* (2) ; John

P. Shockcor(2) ; James I. Langridge(2) ; Johannes P.C. Vissers(2) ;

Johannes M .F.G. Aerts(1)

(1) Academic M edical Centre, University o f Amsterdam,

Amsterdam, Netherlands; (2) Waters Corporation, M anchester,

United Kingdom

Poster PosterPoster 251 - Lipids: Quantitative

AnalysisSkyline Validation of Quantitative Measurements from High-Resolution LC-IMS-MS Lipidomics Profiling Experiments

J. Will Thompson* (1) ; Laura Dubois(1) ; Brian Pratt(2) ; M ichael J.

M accoss(3) ; Giuseppe Astarita(4) ; Brendan M aclean(2) ; Arthur

M oseley(5)

(1) Duke University School o f M edicine, Durham, NC; (2) University

o f Washington, Seattle, WA; (3) Univ of Washington, Seattle, WA; (4)

Waters Corporation, M ilford, M A; (5) Duke University School o f

M edicine, Durham, NC

Ion Mobility: Small Molecules,

Pharmaceuticals, and DMPKOral Ballroom 220/221 9:30am - 9:50am

Comprehensive Screening and Characterisation of Metabolites and Biomolecules by Collisional Cross Section using a

Novel Geometry Travelling-Wave IMS-QTof Mass Spectrometer

Richard Gallagher(1) ; Christine Pattison(1) ; Kathryn Pickup(1) ; Nick

Tomczyk(2) ; M artin Palmer(2) ; Jason Wildgoose(2) ; Darren

Hewitt(2) ; Daniel Weston* (2)

(1) Astrazeneca, M acclesfield, United Kingdom; (2) Waters,


Synthetic Polymers Oral Theater 2:30pm - 2:50pmCharacterization of atmospheric pressure polyolefin pyrolysis products by Fourier transform mass spectrometry and

ion mobility - mass spectrometryCarlos Afonso* (1) ; M athilde Farenc(1, 2) ; M atthias Witt(3) ; Kirsten

Craven(4) ; Caro line BarrÃ¨re-M angote(2) ; P ierre Giusti(2)

(1) University o f Rouen, M ont Saint A ignan, France; (2) TOTAL

Refining and Chemicals, Gonfreville l'Orcher, France; (3) Bruker

Daltonik GmbH, Bremen, Germany; (4) Waters, M anchester, UK

Poster PosterPoster 123 - Environmental Analysis:

GeneralTravelling Wave Ion Mobility Enhanced Separation of Poly-Halogenated Dioxins and Furans in Controlled Burn Samples Kari Organtini* (1) ; Lauren M ullin(2, 3) ; Adam Ladak(3)

(1) The Pennsylvania State University, State College, PA; (2) M TM

Research Centre Ã-rebro University, Ã-rebro , Sweden; (3) Waters

Corporation, M ilford, M A

Poster Poster Poster 62 - PolymersIon Mobility-Mass Spectrometry: A Novel Approach to Screening for Extractable and Leachable Components from

Packaging MaterialBaiba Cabovska* (1) ; Eleanor Riches(2) ; Cristina Nerin(3) ;

M argarita Aznar(3) ; P ilar A lfaro(3)

(1) Waters Corporation, M ilford, M A; (2) Waters Corporation,

Wilmslow, United Kingdom; (3) CPS-University o f Zaragoza,

Zaragoza, Spain

Poster PosterPoster 646 - Ion Mobility: Small

Molecule and MetabolomicsDemonstration of Collisional Cross Section Value Conservation Across LC and GC Analyses

Lauren M ullin* (1, 2) ; Gareth Cleland(2) ; M ike M cCullagh(3) ; Ingrid

Ericson Jogsten(1)

(1) M TM Research Centre Ã-rebro University, Ã-rebro, Sweden; (2)

Waters Corporation, M ilford, M A; (3) Waters Corporation,

Wilmslow, UK

Poster PosterPoster 451 - Informatics: Protein ID

and QuantificationLarge Scale Quantitation of Stable Isotope Labelled Proteomes Using Retention and Drift Time Profiling

Andrew Collins(1) ; Antony M cCabe(1) ; Ian M orns(3) ; Johannes

PC Vissers* (2) ; Andrew R Jones(1)

(1) Institute of Integrative Bio logy, University o f Liverpool, UK; (2)

Waters Corporation, M anchester, UK; (3) Nonlinear Dynamics

Limited, Newcastle upon Tyne, UK

Poster PosterPoster 636 - Ion Mobility: Complex

Mixtures

A Novel Strategy to Screen and Profile Steviol Glycosides of Natural Sweeteners in Food Using Microfluidic UPLC Ion

MobilityRamesh P Rao* (1) ; M ichael M cCullagh(1) ; David Douce(1) ;

SÃ©verine Goscinny(2)

(1) Waters Corporation, M anchester, United Kingdom; (2) Scientific

Institute of Public Health, Brussels, Belgium

Poster Poster

Poster 588 - Proteomics:

Quantitative - Chemical Labeling

Methods

TMT 10-plex Quantitation by Travelling Wave IMS-QTof Mass SpectrometryDominic Helm(2) ; Chris Hughes* (1) ; Jason L Wildgoose(1) ; Keith

Richardson(1) ; Nick Tomczyk(1) ; James I Langridge(1) ; Johannes

PC Vissers(1) ; Bernhard Kuster(2)

(1) Waters Corporation, M anchester, UK; (2) Technische

UniversitÃ¤t M Ã¼nchen, Freising, GERM ANY


Mixtures

Using the Routine Separation Dimension and Identification Criteria of Microfluidic UPLC Ion Mobility to Enhance

Specificity in Screening Complex SamplesM ichael M ccullagh(1) ; C.A.M Pereira(2) ; J.H Yariwake(2) ; David

Douce* (1)

(1) Waters (M S Technologies), Wilmslow, United Kingdom; (2)

Universidade de Sao Paulo, Sao Paulo, Brazil


Molecule and MetabolomicsThe analysis of Bile Acids: Enhancement of specificity using an Ion Mobility-TOFMS based approach

Jonathan P. Williams* (1) ; Jonas Abdel-Khalik(2) ; Yuqin Wang(2) ;

Sarah M . Stow(3) ; M ark Towers(1) ; Giuseppe Astarita(1) ; James

Langridge(1) ; William J. Griffiths(2)

(1) Waters, M anchester, United Kingdom; (2) College of M edicine,

Swansea, UK; (3) Vanderbilt University, Nashville, TN, USA,

Nashville, TN

Poster Poster Poster 208 - Toxicology A Novel Screening Approach for the Detection of Toxicologically Relevant Substances Nayan S. M istry; Jeff Goshawk; M ichelle Wood* Waters, Wilmslow, United Kingdom


Mixtures

Microfluidic UPLC Ion Mobility: A New Approach to Authentication and Routine Screening of Ginsenoside Isomers in

Functional Food ProductsM ichael M ccullagh* ; John Chipperfield; Ramesh P Rao; David

DouceWaters, M anchester, United Kingdom


Mixtures

Baby Elephants Can Surf: Using the Selectivity of Ion Mobility When Screening Multi-class Pesticides in Fruit and

VegetablesSeverine Goscinny* (1) ; M ichael M cCullagh(2)

(1) Scientific Institute of Public Health, Brussels, Belgium; (2)

Waters, M anchester, United Kingdom

Poster PosterPoster 642- Ion Mobility: Small

Molecule and MetabolomicsThe importance of charge isomers in quantitation; ion mobility mass spectrometry of fluoroquinolone antibiotics

Cris Lapthorn* (1) ; M ike M cCullagh(2) ; Sara Stead(2) ; M artin

Palmer(2) ; Kevin Giles(2) ; Keith Richardson(2) ; Jasper

Boschmans(3) ; Frank Sobott(3) ; Frank Pullen(1) ; Babur

Chowdhry(1) ; George Perkins(4)

(1) University o f Greenwich, Chatham M aritime, UK; (2) Waters Corp,

M anchester, UK; (3) University o f Antwerp, Antwerp, Belgium; (4) 149

Hickory Corner Road, M ilford, NJ


Molecule and MetabolomicsIon mobility data in metabolite identification: a Mass-MetaSite approach

Ismael Zamora(1) ; Kevin Bateman(3) ; Fabien Fontaine* (4) ;

Russell M ortishire(2) ; Ian M cIntosh(3)

(1) Lead M olecular Design, S.L., Sant Cugat Del Valles, SPAIN; (2)

Waters Corp, M ilford, M S; (3) M erck, West Point, PN; (4) M olecular

Discovery, London, UK


Molecule and Metabolomics

Multidimensional analytical approaches: combining ion mobility and spectrophotometric detection with current MS-

based metabolomics and lipidomics workflows

Giuseppe Paglia* (1) ; Tommaso Pacini(2) ; Steinn

Gudmundsson(2) ; A Eugenio Chiaravalle(1) ; Sigurdur

Brynjo lfsson(2) ; Bernard O Palsson(2) ; Giuseppe Astarita(3)

(1) IZS Puglia e Basilicata, Foggia, Italy; (2) Center For Systems

Bio logy, Reykjavik, Iceland; (3) Waters Corporation, M ilford, M A


Session: Advances in Software and Hardware to Improve DMPK Workflows When: Monday 09.10 to 09.30 in Ballroom 220/221










Session: Quantitative Analysis in Drug Discovery for Small Molecules When: Monday 16.10 to 16.30 in Ballroom 220/221








Session: Poster 239 – Natural Products When: Monday 10.30 to 13.00










Session: Poster 133 – Ion Mobility: Theory When: Monday 10.30 to 13.00








Session: Poster 510 - Protein Therapeutics: Structural Characterization When: Tuesday 10.30 to 13.00






Session: Ion Mobility: Small Molecules, Pharmaceuticals and DMPK When: Monday 09.30 to 09.50 in Ballroom 220/221










Session: Poster 62: Polymers When: Tuesday 12.00 to 14.30










Session: Poster 208: Toxicology When: Tuesday 12.00 to 14.30








Guide to Waters at ASMS 2015

Documents

The Evolution of Ion Mobility MS - waters.com · ©2015 Waters Corporation 6 2001 Linear Field IMS 2003 First T-Wave IMS 2004 Prototype SYNAPT Q-IMS-Tof 2006 SynaptHDMS TriWave, DriftScope