The Evolving Concept of Mitochondria: From Symbiotic Origins to Therapeutic Opportunities

OrganizersAnu Suomalainen**, University of Helsinki, Finland John E. Walker**, MRC Mitochondrial Biology Unit, UK Douglas C. Wallace**, Children's Hospital of Philadelphia &

University of Pennsylvania Mila Pollock**, Cold Spring Harbor Laboratory** Also Session Chairs & Speakers

Session ChairsValerio Carelli, University of Bologna School of Medicine, ItalyAnne Chomyn, California Institute of TechnologyMarni Falk, Children's Hospital of PhiladelphiaMaria Falkenberg, University of Gothenburg, SwedenToren Finkel, University of PittsburghGyörgy Hajnoczky, Thomas Jefferson UniversityFerdinando Palmieri, University of Bari Aldo Moro, ItalyVincent Procaccio, University of Angers, FrancePeter Rich, Institute of Structural & Molecular Biology, UK

SpeakersAlexey Amunts, Stockholm University, SwedenPaolo Bernardi, University of Padua, ItalyCharles Brenner, The University of IowaDavid Chan, California Institute of TechnologyNavdeep Chandel, Northwestern University, Feinberg School of MedicineJ. Antonio Enriquez, Centro Nacional de Investigaciónes, SpainMichael Gray, Dalhousie University, CanadaClaes Gustafsson, University of Gothenburg, SwedenMarcia Haigis, Harvard Medical School

Mary Herbert, Newcastle University, UKHenry Higgs, Dartmouth Medical School Judy Hirst, MRC Mitochondrial Biology Unit, UK Ian Holt, MRC National Institute for Medical Research, UKHowy Jacobs, University of Helsinki, FinlandLaurie Kaguni, Michigan State UniversityEmine Koç, Marshall UniversityCarla Koehler, University of California, Los AngelesEdmund Kunji, MRC Mitochondrial Biology Unit, UKNick Lane, University College London, UKNils-Göran Larsson, Karolinska Institute, SwedenJennifer Lippincott-Schwartz, HHMI/Janelia Farm Research CampusDan Mishmar, Ben-Gurion University of the Negev, IsraelVamsi Mootha, Harvard Medical SchoolCarlos Moraes, University of MiamiMichael Murphy, Medical Research Council, UKDavid Nicholls, Buck Institute for Research on AgingNikolaus Pfanner, University of Freiburg, GermanyRosario Rizzuto, University of Padua, ItalyAgnès Rötig, L'institut Imagine, FranceJared Rutter, HHMI/University of Utah School of MedicineLeonid Sazanov, Institute of Science & Technology, AustriaEric Schon, Columbia UniversityLuca Scorrano, University of Padua, ItalyOrian Shirihai, University of California, Los AngelesEric Shoubridge, McGill University/MNI, CanadaBruce Spiegelman, Harvard Medical School James Stewart, Max Planck Institute for Biology of Ageing, GermanyAleksandra Trifunovic, University of Cologne, GermanyRichard Youle, National Institutes of HealthIan Young, Australian National University, AustraliaMassimo Zeviani, MRC Mitochondrial Biology Unit, UK

Since it was first observed within cells at the end of the nineteenth century, our bacterial endosymbiont, themitochondrion, has been interrogated from many perspectives. Initially described as a cytoplasmic structure, then as the source of energy, later an organismal entity, and recently a component of many diseases, the multi-faceted mitochondrion has engendered fascination from a broad spectrum of physical,chemical, biological, and medical perspectives.

What is this cell-within-a-cell? Where did it come from? What is its relevance to our health and well being?How will mitochondrial knowledge affect the future? These are the questions we hope to discuss in thisstimulating meeting of modern mitochondriacs who will discuss the past and current status and futureprospects of the field through their important contributions.

The meeting will begin at 7 pm on Thursday, October 18th and conclude at 4:40 pm on Sunday, October 21st.

Cold Spring Harbor, New York

Cold Spring Harbor Laboratory | Meetings & Courses Program

October 18 - 21, 2018 Poster Abstract Deadline: September 15 Meeting Website: meetings.cshl.edu/history18

TopicsMitochondrial Biology, Bioenergetics, •Biogenesis and Disease The Origins of the Organelle•Complex I - from Structure to Disease•Mitochondrial DNA: Structure, Function and•Inheritance Mitochondrial Expression System and •Proteome

Mitochondrial Protein Import Systems and •Metabolic TransportersMitochondrial Diseases, Past and Present•Mitochondrial Regulation of Metabolism•Mitochondria, Calcium signaling, and Cell Death•Mitochondrial Dynamics and Quality Control•Novel Approaches to Mitochondrial Therapy•Wrap-up Discussion: Preserving the History of •Mitochondrial Research