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The Future of Humanity in Hands of Our Inner Clock
Preparing for the Biggest Changes.
Preparados para Afrontar los Cambios mas
Importantes en la Historia del Hombre
Tras la Enfermedad el Enfermo, tras el Enfermo
el Hombre
Human Being behind the Disease
Paris, Bruselas, Afganistan, Ucrania, Rusia, Madrid, Barcelona, hambruna en Somalia Sunami, Siria, USA. Climate ChangeSexual discrimination, Inmigration stormMensajes negativos Si hay sangre vende
Conquistas en los últimos 100 años
Steve Pinker
•La epoca mas pacifica de la historia
Charles Kenny
•La alfabetización ha pasado del 25% al 80% en los últimos 130 años
Population explosión of Internet Users
• BROADCAST 2017 $ 23 BILLIONS
• Global conversation 2020 3 billion New Minds
Source: GSMA, “Touching Lives through Mobile Health: Assessment of the Global Market Opportunity”, February 2012
6%2000
6%2000
66%2020
66%2020
Global Populationbillions 23%23%
3 BILLION
Crecimiento tecnologico exponencial
“infinite computing”Sensors Netwoks
Robotics3· D Printing
Synthetic BiologyDigital medicineNanomaterials
Artificial IntelligenceCNN Deep learning 95 VS 86.6
Hyperloop one
“infinite computing”Sensors Netwoks
Robotics3· D Printing
Synthetic BiologyDigital medicineNanomaterials
Artificial IntelligenceCNN Deep learning 95 VS 86.6
Hyperloop one
Mas tiempo para ser felices
85.9—71.3 %
80.4– 68.4%
Lancet 28.08.2015
FranciscoNuñez Badajoz112 años
20162016
2016
Human Developmen What is life? “Heredity molecule”Erwing Schorodinger 1943 statistical Physics and Quantum Mechanics
Implications of Telomere Maintenance in Aging-Related
Disease Progression
Fundacion Fernandez-Cruz, MadridOctober 26, 2015
Elizabeth Blackburn, PhD
University of California San Francisco
10.000 DNA LESSIONS PER DAYPER CELL
DNA repairLindahlModrichSancar
Validation of role of telomerase in cancer & aging
Blasco et al., Science (1995)Blasco, Lee, et al., Cell (1997)Lee, Blasco, et al., Nature (1998)
González-Suarez et al., Nat Genet (2000)Flores et al., Science (2005)
�Premature loss of regenerative capacity of tissues (stem cell mobilization defects)
�Anticipation of many aging-associated pathologies (skin, gut, bone marrow etc)
�Resistant to cancer in late generations (when telomeres become short)
�Premature loss of regenerative capacity of tissues (stem cell mobilization defects)
�Anticipation of many aging-associated pathologies (skin, gut, bone marrow etc)
�Resistant to cancer in late generations (when telomeres become short)
Terc-/-
mice
Elizabeth Parrish 2015Aaron Traywick 2018
Trujillo E et al. J Am Diet Assoc 2006;106:403-413en Epigentic-clock Genome Biology Octob 2013.Nature 508-168 Aprl 2014
The clock-watcher the chemical clock Steve Horvath
CpG sites28 mill16-353Sites96-99.7%
Global M
ethylation HIST
ON
AS
RestingEndothelial Cell
Thrombin
ActivatedEndothelial Cell
TLR2
ActivatedMacrophage
ActivatedDegranulating
Platelet
RestingPlatelet
RestingSmooth
Muscle Cell
ProliferatingModulated
Smooth Muscle Cell
ReactiveReactiveOxygen SpeciesOxygen Species
Tissue FactorTissue FactorProcoagulantProcoagulant
ProPro --inflammatoryinflammatoryCytokinesCytokines
Lipid mediatorsLipid mediatorsOf inflammationOf inflammation
Pro-inflammatoryMediators
(e.g., CD40L, RANTES, IL-6)
Consequences of EROSIONConsequences of EROSION
Croce K, Libby P. Intertwining of thrombosis and in flammation inCroce K, Libby P. Intertwining of thrombosis and in flammation in atherosclerosis. Curr Opin atherosclerosis. Curr Opin Hematol. 2007;14:55Hematol. 2007;14:55 --6161
PMNNETs
PMNNETs
Paul M Paul M RidkerRidker , MD, MPH, MD, MPHEugene Eugene BraunwaldBraunwald Professor of MedicineProfessor of Medicine
Director, Center for Cardiovascular Disease PreventionDirector, Center for Cardiovascular Disease PreventionBrigham and WomenBrigham and Women ’’s Hospitals Hospital
Harvard Medical School, Boston, MA USAHarvard Medical School, Boston, MA USA
Dr Ridker is listed as a co-inventor on patents held by the Brigham and Women’s Hospital
that relate to the use of inflammatory biomarkers in cardiovascular disease and diabetes.
XXVIII XXVIII LeccionLeccion Memorial 2009Memorial 2009
New Insights into the Biology of Atherosclerosis New Insights into the Biology of Atherosclerosis and Primary Prevention:and Primary Prevention:
Controversy and Consensus in the JUPITER TrialControversy and Consensus in the JUPITER Trial
Can targeted AntiCan targeted Anti--Inflammatory Therapy Inflammatory Therapy Reduce Cardiovascular Risk?Reduce Cardiovascular Risk?
Aspirin / StatinsAspirin / Statins
Direct CRP inhibitorsDirect CRP inhibitors
DMARDs/ MTXDMARDs/ MTX
TNF / ILTNF / IL--6 Inhibitors6 Inhibitors
ILIL--1 receptor antagonism1 receptor antagonism
CIRT MTX 15 VS 20 mg/week CIRT MTX 15 VS 20 mg/week ekek
Leukotriene blockadeLeukotriene blockade
CCR2/CCR5CCR2/CCR5
LpLp --PLA2 inhibitionPLA2 inhibition
spLAspLA inhibitioninhibition
RNAiRNAi / anti/ anti --sensesense
““ CANTOS trialCANTOS trial ”” canakinumabcanakinumab
Immunization strategies 5Immunization strategies 5 --LO LO
May 22 2018May 22 2018
LA MEDICINA “DE PRECISIÓN”La cumbre de una revolución
• CARACTERISTICAS PERSONALES
• EL EXPOSOMA Y LA MICROBIOTA
• LA REVOLUCIÓN TECNOLOGICA. EMPODERAMIENTO Y BIG DATA.
• LAS CELULAS MADRES Y LA EDICIÓN DE GENES . TERAP IA G.
• La inmunoterapia con celulas T y CAR,
ACT tumor-infiltrating lynphocytes
• EL AUMENTO DE LA LONGEVIDAD-TRANSHUMANISMO
JudyPerkins
JudyPerkins