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The NIH Biomedical Translational Research Information System
(BTRIS)James J. Cimino, MD
Chief, Laboratory for Informatics DevelopmentNIH Clinical Center
Town Hall MeetingLipsett Amphitheater
Tuesday, September 16, 2008
PatientAccrual
Data in the Research Process
RecruitmentPublications
IRBApproval
Write Protocol
HypothesisGeneration
Reporting
Data GatheringAnd Analysis
Access to Research Data at NIH• Data are in:
– CRIS– Institute/Center systems– Archives– Individual laboratory systems– Lab notebooks
• Data to be analyzed by:– Subject– Cohort
• Data needed for reporting:– Institutional Review Board– ClinicalTrials.Gov
• Reuse of data– Secondary studies– Hypothesis generation and testing– Patient recruitment
BTRIS Proof-of-Concept Demo• PIs volunteered 29 protocols• Protocols included 8000 patients• Collected all data on 8000 patients from:
– Clinical Research Information System (CRIS)– Clinical Data Repository (CDR)– Clinical Research Information Management
System of the NIAID (CRIMSON)• Data types:
– Demographics– Vital Signs– Laboratory– Radiology– Medications
BTRIS Proof-of-Concept Demo• Data “scrambled”:
– All dates shifted, relative to a random, patient-specific date
– All numeric values randomly altered
• Access open to all NIH investigators– NIH ID– Request password– Canned reports– Ad hoc queries
• Demonstration purposes only!
B RISB RIS
BTRIS in the Research Process
Recruitment
PatientAccrual
Publications
IRBApproval
Write Protocol
HypothesisGeneration
Reporting
Data GatheringAnd Analysis
BTRIS in the Research Process
B RISB RIS Recruitment
PatientAccrual
Publications
IRBApproval
Write Protocol
HypothesisGeneration
Reporting
Data GatheringAnd Analysis
BTRIS in the Research Process
B RISB RIS Recruitment
PatientAccrual
Publications
IRBApproval
Write Protocol
HypothesisGeneration
Reporting
Data GatheringAnd Analysis
BTRIS in the Research Process
B RISB RIS Recruitment
PatientAccrual
Publications
IRBApproval
Write Protocol
HypothesisGeneration
Reporting
Data GatheringAnd Analysis
BTRIS in the Research Process
B RISB RIS Recruitment
PatientAccrual
Publications
IRBApproval
Write Protocol
HypothesisGeneration
Reporting
Data GatheringAnd Analysis
BTRIS in the Research Process
B RISB RIS Recruitment
PatientAccrual
Publications
IRBApproval
Write Protocol
HypothesisGeneration
Reporting
Data GatheringAnd Analysis
Access to BTRIS
• NIH User ID
• Password request to Adam Pleasant:[email protected](301) 443-7490
• After this session in Lipsett Lobby
• btris.nih.gov
btris.nih.gov
btris.nih.gov
