Third Year : First Semester - ust.eduust.edu/img/مواد المستوى الثالث.pdf · Department offering the programme: Faculty of Pharmacy Department offering the course:

University of Science & Technology

Faculty of Pharmacy

جامعة العلوم والتكنولوجیا كلیة الصیدلة

Third Year : First Semester Courses Titles Code /

No Credit Hours Credit

Hours Pre-Requisites Lecture Practical Tutorial

1 Pharmacology I BPH24 2 - - 2 BPH12,BPH09,BPH36/Co-Req

2 Pharmaceutical Technology 1 BPH27 2 1 - 3 BPH16

3 Pharmaceutical Chemistry I BPH30 2 - - 2 BPH07

4 Phytochemistry I BPH33 2 - - 2 BPH14

5 Microbiology and Immunology BPH35 2 1 - 3 BPH03

6 Pathology BPH36 2 - - 2 BPH09 7 Instrumental Analysis BPH37 2 1 - 3 BPH15 8 Professional Skills III BPH19 1 - - 1 BPH18

Total of Credit Hours 15 3 - 18

Third Year : Second Semester Courses Titles Code /

No Credit Hours Credit

Hours Pre-Requisites Lecture Practical Tutorial

1 Pharmacology II BPH25 3 - - 3 BPH24

2 Pharmaceutical Technology II BPH28 2 1 - 3 BPH27

3 Pharmaceutical Chemistry II BPH31 2 - - 2 BPH30

4 Phytochemistry II BPH34 2 1 - 3 BPH33

5 Pharmaceutical Microbiology BPH38 2 1 - 3 BPH35

6 Pathophysiology I BPH39 2 - - 2 BPH36 7 Nutrition BPH41 2 - - 2 BPH11 8 Professional Skills IV BPH20 1 - - 1 UST07

Total of Credit Hours 16 3 - 19


Faculty of Pharmacy


Pharmacology I

Programme(s)on which the course is given: Pharmacy Major or minor element of programmes Department offering the programme: Faculty of Pharmacy Department offering the course: Pharmaceutical Sciences Academic year/Level: Third year – first semester Date of specification approval: / / A-BASIC INFORMATION Title: Pharmacology I Code: BPH24 Credit hours:2 Lecture: 28hrs Tutorial: within practical classes Practical: - Total:28hrs B-PROFESSIONAL INFORMATION 1-Course Description: This course is dealing with pharmacological principles, pharmacology of autonomic system, cardiovascular system, autocoids, and vitamins Overall aim of course: The aim of the course is to provide students with information about the actions and uses of a number of pharmacologically active drug classes and to explain efficiently the mechanisms by which different members of each class act on their target receptors. They must also be able to discuss professionally pharmacokinetics and adverse effects of CVS and ANS drugs. 2-Intended Learning Outcomes of course (ILOs) A-Knowledge and Understanding: The student should be able to:

a.1. Understand the principles of general pharmacology. a.2. Distinguish between different groups of drugs acting on ANS a.3. Recognizing the effect of drugs on CVS diseases a.4. Distinguish between different types of autocoids and drugs acting on them.

B-Intellectual skills: The student should be able to:

b.1 Retrieve the information about general pharmacology including pharmacokinetics,

pharmacodynamics of drugs b.2 Evaluate patient’s condition seeking help at the ANS abnormalities and their treatment. b.3 Sort the proper drugs that are acting on different diseases of CVS


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b.4 Differentiate between agents that acting on different types of autocoids C-Professional and practical skills: The student should be able to:

c.1. Choose the suitable medication for ANS abnormalities according to their pharmacokinetics

and pharmcodynamics c.2. Interpret the cause for choosing the suitable medication for different CVS diseases. c.3. Evaluate the gained information during patient counseling to select & provide suitable

autocoids D-General and transferable skills: The student should be able to: d.1 Demonstrate critical thinking, decision making, synthesis and interpretation of

pharmaceutical information, and responsibility. d.2 Obtain required scientific information from available sources. d.3 Develop the ability to work with equations and learn how to choose the suitable

medications for different ailments.

3-Contents:

No. Topic Lectures 1 Introduction of Pharmacology

-Drug receptors & pharmacodynamics -Pharmacokinetics: absorption, distribution, metabolism and excretion. -Dosage forms & advantages and disadvantages -Drug-protein binding -Adverse drug action -Drug interactions

10

2 Autonomic Nervous System -Introduction -Sympathomimetic agents -Sympatholytic agents -Parasympathomimetic agents -Parasympatholytic agents -Drugs acting on ganglia

10

3 Cardiovascular system -Diuretic agents -Antihypertensive drugs -Antianginal agents -Drugs for heart failure -Antiarrhythmic agents -Drugs for shock

14


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4 Autocoids -Histamine and antihistamines -Serotonin receptors agonist & antagonists -Eicosanoids, and their uses -PAF, bradykinin

3

5 Vitamins (seminars) 2 Total 39

4-Teaching and learning methods Lectures Computer, data show, white board, marker, OHP. Practical Experimental animals, drugs, laboratory chemicals, anesthetics. 5-Student assessment method To evaluate the understanding skills of students, in midterm or final exam.to the studied topics of the course.

Assessment Weight Description

a First test 20%

b Second test 20%

c Assignments 10% d Final test 50% Total 100%

6-List of references 6.1-References: Textbook: Rang, Dale and Ritter Pharmacology (2009) Supplementary reading: Katzung –Basic and Clinical Pharmacology (2009) 6.3-Websites in international network (internet). 7-Facilities required for teaching and learning Laboratory glassware, chemicals, computers, data show and OHP. Course coordinator: Head of department:


Faculty of Pharmacy


Pharmaceutical Technology I

Programme(s)on which the course is given: Bachelor of Pharmacy Major or minor element of programmes Department offering the programme: NA Department offering the course: Pharmaceutical Sciences Academic year/Level: Third year-First semester Date of specification approval: / / A-BASIC INFORMATION Title: Pharmaceutical Technology I Code: BPH27 Credit hours: 3 Lecture: 28 hrs Tutorial: within classes Practical: 12 Total: 40 B-PROFESSIONAL INFORMATION 1-Course Description: This course describes the preparation of pharmaceutical dosage forms. It relates the basic scientific background to pharmaceutical practice regarding the dosage forms preparation and quality control. Liquid dosage forms, parenteral preparations, and aerosols will be covered. Overall aim of the course: The aim of present course is to describe the scientific and technological aspects of the design and manufacture of covered dosage forms. 2-Intended Learning Outcomes of course (ILOs) A-Knowledge and Understanding: The student should be able to:

1. Define the different dosage forms and routes of drug administration. 2. Discuss the different aspects of preparation and labeling of liquid dosage forms,

ophthalmic preparations, parenteral preparations, and disperse systems.


1. Compare between different dosage forms and routes of administration. 2. Choose rationally the adjuvants, preparation methods, and equipments of different

formulations.


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C-Professional and practical skills: The student should be able to:

1. Handle chemicals properly and safely. 2. Operate machinery used properly. 3. Collect data from different equipments used. 4. Conduct experiments and analyze results.

D-General and transferable skills: The student should be able to: d.4 Demonstrate critical thinking, synthesis and interpretation of pharmaceutical

information, and responsibility. d.5 Manage time effectively. d.6 Work effectively as a part of team in order to fulfill certain project. 3-Contents:

Week Topic

1 Introduction to pharmaceutical technology, dosage forms, and routes of administration

2-4

Solutions: • Advantages and disadvantages • Choice of solvents • Formulation additives • Types of liquid preparations • Manufacture of solutions • Filling of solutions

5-6

Suspensions: • Pharmaceutical applications of suspensions • Formulation and stability of suspensions • Formulation additives • Quality control of suspensions

7-9

Emulsions: • Types of emulsions • Formulation of emulsions • HLB value • Emulsifying agents • Stability of emulsions • Manufacture of emulsions


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10-12

Parenteral preparations: • Types • Advantages and disadvantages • Vehicles used • Formulation additives • Sterilization of parenterals • Containers and closures • Formulation issues • Quality control

13

Ophthalmic products: • Characteristics • Types • Formulation of eye drop • Packaging

14

Aerosols: • Principle • Pharmaceutical applications • Aerosol systems • Metered dose inhalers • Dry powder inhalers • Nebulizers • Filling operations

Practical Part: Week Experiment 1 Orientation 2 Pharmaceutical Solutions I 3 Pharmaceutical Solutions II 4 Pharmaceutical Solutions III 5 Pharmaceutical Suspensions I 6 Pharmaceutical Suspensions II 7 Pharmaceutical Emulsions I 8 Pharmaceutical Emulsions II 9 Pharmaceutical Emulsions III 10 Parenteral Preparations I 11 Parenteral Preparations II 12 Parenteral Preparations III 4-Teaching and learning methods

• Lectures (Tools: board, overhead projector, pc and data- show projector). • Practical sessions. • Assignments (Report writing).


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5-Student assessment method To evaluate the understanding and ability to develop required skills of students, in midterm or final exam. Weighing of assessments:


a First test 15%

b Second test 15%

c Activities 5%

d Final test 35%

e Practical part 30%

Total 100% 6-List of references 6.1-Course notes provided to the students 6.2-Textbooks:

• Text Book: Pharmaceutical dosage forms and drug delivery systems ( HowardAnsel, Loyd Allen, Nicholas Popovich)

• Supplement (s) 1- Pharmaceutics: the science of dosage form design (M.E. Aulton) 2- The Theory and Practice of Industrial Pharmacy (Lanchman, L., Lieberman, H.,

and Kanig, J.) 3- Remington: The Science and Practice of Pharmacy

6.3- Websites in international network (internet). 7-Facilities required for teaching and learning Lecture rooms, computers, data show, library, and internet access. Course coordinator: Head of department:


Faculty of Pharmacy


Pharmaceutical Chemistry I

Program (s)in which the course is given: Bachelor of Pharmacy Major or minor element of programmes Department offering the programme: Pharmacy Department offering the course: Pharmaceutical Chemistry and Natural Prodcuts Academic year/Level: Third year- First Semester Date of specification approval: A-BASIC INFORMATION Title: Pharmaceutical chemistry I Code: BPH30 Credit hours: 2 Lecture: 28 hours Tutorial: within lecture classes Practical: Total: 28

B- Professional Information

1- Course Description:

The course includes introduction to pharmaceutical chemistry, its importance in the field of drug

inducting and drug discovery. The course includes the study of several chemical classes of drugs.

The chemical structure of these compounds, their method of preparations, purification and their

method of assay will be studied.

Overall aim of course:

Get knowledge about the chemistry of drugs.

2- Intended learning outcomes of course (ILOs)

A- Knowledge and understanding:

At the end of the course the student should be able to:

a.1 Understand the basic background of the pharmacology and the chemical structures of

drugs.

a.2 Understand the general metabolic pathways of drugs.

a.3 Understand the chemical synthesis of selected drugs.

a.4 Understand the structure-activity relationship (SAR) of drugs.

B- Intellectual skills:


b.1 Discuss and analyze the basic structures of therapeutic groups

b.2 Discuss and analyze the main metabolic pathways of drugs.

C- Professional and practical skills:



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c.1 Guess the pharmacological activity of drugs, based on the structure-activity relationship

(SAR).

c.2 Working in factories, pharmaceutical companies, and other health facilities, in the field of

new drugs design, and quantitative and qualitative determination of drugs.

D- General and transferable skills:

At the end of the course the student should be aware about:

d.1 The importance of continuous self-study of drugs

d.2 Coordinate the basic and the practical knowledge of drugs

3- Contents

Lectures

No. Title Hours

1 Review of heterocyclic compounds 2

2 Drug metabolism 1 2

3 Drug metabolism 2 2

4 Sympathomimetic drugs 2

5 Sympatholytic drugs 2

6 Parasympathomimetic drugs 2

7 Parasympatholytic drugs 2

8 Ganglionic blockers 2

9 Neuromuscular blockers 2

10 Diuretics, CA inhibitors, thiazides 2

11 Diuretics, Loop, K-sparing, osmotic 2

12 Local anesthetics 2

13 Antihistamines1 2

14 Antihistamines2 2

|Total 28

4-Teaching and learning methods

Lectures

Computer, data show, white board, marker.

5- Student assessment method

To evaluate the understanding and ability to develop required skills of students, in midterm or final exam.


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Weighing of assessments:


a First test 20%

b Second test 20%


6- References

Textbook:

John H Block and John M Beale Jr., Wilson and Gisvold’s Textbook of Organic,

Medicinal and Pharmaceutical Chemistry, 2004, 11th Edition, Lippincott Williams &

Wilkins.

Supplement:

Adel Nofal, Pharmaceutical Chemistry, DamascusUniversity Publications, 2007, 3rd

Edition. (Arabic book)

7- Facilities required for teaching and learning

White board, data show, textbooks and laboratory.

Course coordinator:

Head of departement:


Faculty of Pharmacy


PhytochemistryI

A-BASIC INFORMATION Title: Phytochemistry I Code: BPH33 Credit hours:2 hours Lecture:2 hrs B-Professional Information

1- Course Description: This course focuses on the study of active ingredients of crude drugs based on chemical classification. The study includes methods of isolation, identification, qualitative and quantitative evaluation, medicinal uses, physical and chemical properties and drug structure and medical activity relationship Overall aim of course: A- Giving knowledge about the main active constituents present in medicinal plants and responsible for the therapeutic actions. B- Nomenclature of these compounds according to IUPA. C- Classification of the main active constituents according to their structures. D- Giving an idea about different methods used for isolation of the different groups of the active constituents. E- Identification and determination of the main active constituents using different methods including physical, chemical and chromatographyical methods. F- Giving an idea about the main uses of different group of compounds, abuses, side effects and toxic effects

2- Intended Learning Outcomes of Course(ILOs)

a-Knowledge and Understanding : 1. To acquire knowledge about the main active constituents present in the

herbal drugs and natural products, their actions, side effects and toxicity 2. To acquire a knowledge about the different methods for isolation,

identification of these active constituents 3. To get a skill about the prescription of these ingredients for treatment of

different ailments. 4. To get a knowledge about the recent research articles and advanced studies

on these compounds concerning their modern uses. b-Intellectual Skills

1. The student can classify the active constituents according to their therapeutic uses

2. The student can choose the best methods for isolation and identification of the different group of compounds according to their chemical character.

3. Differentiate between the different compound in the same group using different methods.

c- General and Transferable Skills


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1. Communication skills 2. Skill to use different methods for identification of natural drugs 3. Writing reports for criticizing natural compounds

General and Transferable Skills

1. Communication skills 2. Skill to use different methods for identification of natural drugs 3. Writing reports for criticizing natural compounds

3- Contents The subject

٢ Chromatography

Basic concept (partition and adsorption chromatography), Separation techniques (elution, frontal, and displacement analysis),

1

2 Chromatography

Types of chromatographic methods: Paper chromatography, Thin layer chromatography (TLC),

2

٢ Chromatography

Types of chromatographic methods: Column chromatography (CC), Gel chromatography.

3

٢ Chromatography Gas chromatography (GC). 4

٢ Chromatography Performance liquid chromatography (HPLC). 5

٢

Terpenoids Introduction (definition, classification, biosynthesis and distribution).Monoterpens: (regular- and irregular monoterpenoids, irodoids, structures, chemical and physical properties and drugs containing monoterpenoids)

6

٢

Terpenoids Sesquiterpens and sesquiterpen lactones: (structures, chemical and biological properties, and drugs containing sesquiterpenes and sequiterpene lactones).

7

٢ Mid term exam 8

٢

Terpenoids Diterpenes : (structures, chemical and biological properties, and drugs containing diterpenes), Triterpenes : (classification, structures, and drugs containing triterpenes). Tetraterpenes : ( chemical and biological properties, vitamin A, and drugs containing tetraterpenes) .

9

٢ Steroids

- Definition, classification, structures, chemical and physical properties, characterization.

10


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§ - Sterols (Definition, classification, structures, chemical and physical properties, Pharmacological Importance).Vitamin D (Sources, structure, action, clinical uses)

§ Bile acids (Structure, action and uses) Steroid hormones (Sexual hormones and corticoids, classification, structure, action and clinical uses.

٢

Glycosides Introduction : (Definition, classification, distribution extraction and isolation, pharmacological properties).

Cardioactive glycosides

١١

٢

(cardenolides, bufadienolids, sugars, structure- activity-relationship, distribution, extraction, chemical and physical properties, hydrolysis of cardiac glycoside, biogenesis, pharmacological properties, mechanism of action, chemical tests, chief drugs containing cardiac glycosides, Digitalis, Strophanthus, Adonis, Convalaria and Squill).

١٢

٢

Glycoside Anthracenglycosides : (distribution, classification, structures, biosynthesis, extraction, chemical and physical properties, characterization, pharmacological properties, Senna, Rhamnus, Rhabarub and Aloe).

13

٢

Glycosides Saponin-glycosides : (Definition, distribution, classification, structures, biogenesis, extraction, chemical and physical properties, Characterization biological and pharmacological properties, drugs as expectorant and antitusive, anti-exudative, Adaptogens and as diuretic).

14

28h Total 4- 4- Teaching and Learning Methods 4.1-OHP 4.2- Data show 4.3- White board, marker 4.4-Computer 5- Student Assessment Methods To evaluate the understanding and ability to develop required skills of students, in midterm or final exam. Weighing of assessments:



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a First test 20%

b Second test 20%


6- List of References Textbook Balbaa,S., et. al. "Chemistry of Natural Products", 1976 Supplements: Trease G. E. and Evan W. C. " Pharmacognosy", 2002. Balbaa,S., et. al. Practical Notebook in "Chemistry of Natural Products", 1976. 6.2- Periodicals, Web Sites, ….etc 7- Facilities Required for Teaching and Learning Chemicals, glass wears, computer, data show, OHP. Head of Department: Date:


Faculty of Pharmacy


Microbiology and Immunology

Program (s)in which the course is given: Bachelor of Pharmacy Major or minor element of programmes Department offering the programme: Pharmacy Department offering the course: Microbiology Academic year/Level: Third year- First Semester Date of specification approval: A-BASIC INFORMATION Title: Microbiology and Immunology Code: BPH35 Credit hours: 2+1 Lecture: 26 hours Tutorial: within lecture classes Practical: 13 Total: 41 B. PROFESSIONAL INFORMATION


A study of the biological characteristics of different groups of microorganisms; their classification, morphology, anatomy, chemistry, nutrition, metabolism, biosynthesis, growth and genetics. The study includes principles of immunology. Overall Aims of Course: a. Introducing major groups of microorganisms b. Providing detailed information on bacteria (prokaryotes), viruses and fungi, and their characteristics c. Developing an understanding of microbe-host interactions, infectious diseases, and their modes of spread d. Introducing components, functions, mechanisms as well as disturbances of the immune system e. Introducing basic bacteriological and immunological laboratory techniques

2- Intended Learning Outcomes of course (ILOs)

a. Knowledge and Understanding

The student should be able to:

a1 define morphology, structure, physiology, genetics, and taxonomy of bacteria, viruses and fungi.

a2 enumerate and categorize bacterial, viral and fungal pathogens and describe their modes of transmission, infection patterns and pathogenic mechanisms.

a3 describe methods used in cultivation, counting and identification of bacteria, fungi, and viruses.

a4 identify components of innate and acquired immunity, describe immune reactions to different infections, regulatory mechanisms involved and define immunological disorders.


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b. Intellectual skills:

b1 develop holistic images of bacterial, viral and fungal infections integrating microbial factors, host components, clinical features, and pharmacological management.

b2 distinguish infections from other inflammatory diseases or immunological disorders with particular reference to pharmacological aspects.

c. Practical skills: The student should be able to perform sampling, quantification, and identification of

bacteria/fungi, and to interpret results from immunological techniques.

d. General and transferable skills:

d1 Communication d2 Developing an independent approach to acquiring knowledge d3 Reading and searching the literature d4 Taking responsibility of own work

3- Contents:

• Lectures

No. Topic Hours 1 Introduction to microbiology 2 2 Bacterial Structure 2 3 Bacterial physiology and growth 2 4 Bacterial Taxonomy 3 5 Bacterial genetics 3

6 An introduction to viruses 2 7 An introduction to fungi 2 8 Host-microbe interaction – introduction to infectious diseases 2 9 Pathogenesis of infections 2

10 Introduction to immunology – innate immunity 2 11 Acquired immunity part I 2

12 Acquired immunity part II 2 13 Immunological disorders – immunological techniques 2 Total 26

• Practical


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No. Topic Hours 1 Microscopy ٢ 2 Performing Gram staining ٢

3 Morphology and reaction of various bacterial pathogens to Gram stain – ready slides ٢

4 Staining of fungi – morphology of common fungal pathogens (ready slides) ٢

5 Types of culture media ١ 6 Preparation, inoculation and cultivation of media ١ 7 Colonies, isolation and pure cultures ١ 8 Biochemical tests ١ 9 Immunological techniques ١

Total ١٣

4- Teaching and learning methods

• Lectures: PowerPoint presentations, animations, and videos • Practical: Gram-stain, culture media, reference bacterial/fungal strains, biochemical

tests, incubators, microscopes, slide projector.

5- Student assessment To evaluate the understanding and ability to develop required skills of students, in midterm or final exam. Weighing of assessments:


a First test 15%

b Second test 15%

c Activities 5%

d Final test 35%


Total 100%

6- List of references

a. Course notes (lecture notes and practical notes) prepared by staff members b. Required Textbook: Mim’s Medical Microbiology, 3rd ed. Elseiver. c. Supplementary reading: Medical Microbiology and Immunology, Warren Levinson

&Jawetz, 6th edition.


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Pathology

Program (s) on which the course is given Major or Minor element of programs Department offering the program: Faculty of Pharmacy Department offering the course: pathology Dept. Academic year / Level 3rd level, 1stsemester Date of specification approval A-Basic Information

Title: Pathology Code: BPH36 Credit Hours: 2 hrs Lecture: Lecture: 2hrs/week/semester Total: 28 hours

B) Professional information

I. Course Description:

This course describes the basics of general and systemic pathology. This includes the essential basic scientific knowledge required to understand the structure and functional deviations from the normal in the various body systems and organs.

Overall aim of the course:

By completion of the course the students will:

- Be familiar with the basics of general and systemic pathology.

- Demonstrate the essential basic scientific knowledge required to understand the structure and functional deviations from the normal in the various body systems and organs.

- Know basic disease patterns and their underlying mechanisms within the specific organ systems as step to preparing the student for his clinical rounds and future as a practitioner.

2. INTENDED LEARNING OUTCOMES:

a- KNOWLEDGE and UNDERSTANDING:

By the end of the course, students should be able to:

a1-Define and discuss the main disease categories that may affect the body (general pathology) as well as the basic mechanisms underlying these disorders (etiology, pathogenesis and natural history).


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a2- Describe the morphologic changes occurring as a result of such disease processes in various organs. a3- Define medical terms of disease process. a4- Describe how diseases occur (pathogenesis) a5- Explain how disease progress (outcome) B- Intellectual Skills By the end of the course, students should be able to: b1- Predict the signs and symptoms of a disease based on the underlying tissue changes responsible for symptomatology and physical changes in the patient b2- Recognize patients with life/organ threatening conditions. c-PROFESSIONAL AND PRACTICAL SKILLS (CLINICAL & LABORATORY SKILLS): By the end of the course, students should be able: C.1- Demonstrate the ability to identify the macroscopic and microscopic criteria of the altered structure and hence function (pathology & pathophysiology) of the body and its major organs & systems that are seen in various diseases and conditions. C.2- Recognize the macroscopic and microscopic criteria of the altered structure (Pathology) of the body and its major organs that are seen in various diseases and conditions. d- GENERAL AND TRANSFERABLE SKILLS By the end of the course, students should be able to: d1- Appreciate the importance of life long learning and show a strong commitment to it d2- Use the sources of biomedical information to remain current with the advances in knowledge & practice d3- Identify difficult ethical situations and how to properly deal with them d4- Express themselves freely and adequately by improving their descriptive capabilities and enhancing their communication skills 3. COURSE CONTENTS:

Topics hours Introduction to pathology & Cell injury, necrosis 4 adaptation 2 Inflammation(Acute, chronic & granulomatous) & healing 2 Circulatory disturbance ;thrombosis, embolism, ischemia &infarction 2 Circulatory disturbance; congestion&oedema 2 Immunology : hypersensitivity, autoimmune disease and immunodeficiency.

2

Neoplasia: ( definition, incidence, terminology, classification, and characteristics of benign &malignant tumors

2

Cardio-vascular :(atheroma, hypertension, ischemic heart disease, infective endocarditic ) 2 Haemopoetic&lymphoid system:-anemia (classification, signs& symptoms), leukemia, lymphoma 2 Respiratory system: Pneumonia, T.B., COPD.

2

GIT: Peptic ulcer, liver abnormalities, and inflammatory bowel disease

2

Renal: Renal failure and urinary tract infections

2

Genital system Endometriosis, prostatic hyperplasia and malignancy.

2

Total 28 hours


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IV. TEACHING & LEARNING METHODS: IV-A: METHODS USED: 1- General lectures 2- Seminars & discussions 3- Self study TEACHING PLAN: LECTURES Lectures: Lectures are going to be in the form of interactive and discussion type. Lectures will address the specific objectives of each topic and try to clarify and demonstrate important concepts. Flow chart, tables and photographs used will be similar to those in the recommended textbook whenever possible. Handouts of all lectures will be available. Lectures should be Illustrated, animated contain video clips or film strips or contain explanatory diagrams and algorithms. (Use data show, overhead projectors and white board). Seminar: Pre selected subject in each system will be presented by few students. V. TEACHING & LEARNING FACILITIES: Facilities used for teaching this course include: 1- Data show 2- Overhead projector 3- Slide projector VI. STUDENT ASSESSMENT: To evaluate the understanding and ability to develop required skills of students, in midterm or final exam. Weighing of assessments:


a First test 20%

b Second test 20%


EXAMINATION DESCRIPTION:

- A written exam (MCQ & short essays) covering topics in pathology. VII. LEARNING AND REFERENCE MATERIALS: v Essential books: Basic Pathology by Kumar, Cotran& Robbins 8th edition, v Recommended books: Muir' pathology, MNS series of Pathology(lat edition). v Handouts of all lectures will be available at the department.


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v Important web sites: http://www.medicine.cu.edu.eg/beta/en/jcalpro/2428.html http://www.kasralainy.edu.eg/elearning/ http://www.pathmax.com/ http://www-medlib.med.utah.edu/WebPath/LABS/LABMENU.html#2 http://www.med.uiuc.edu/PathAtlasf/titlePage.html http://www.medscape.com/pathologyhome http://www.gwumc.edu/dept/path/2F.HTM http://www.path.uiowa.edu/virtualslidebox/ http://web.med.unsw.edu.au/pathology/Pathmus/pathmus.htm#InteractiveImages http://www.virtualpathology.leeds.ac.uk/ http://histopathsho.34sp.com/index.html http://pathology.class.kmu.edu.tw/index.htm http://www.gla.ac.uk/faculties/medicine/teaching/MedCALlist.htm

http://www.medicine.cu.edu.eg/beta/en/jcalpro/2428.html

http://www.kasralainy.edu.eg/elearning/

http://www.pathmax.com/

http://www-medlib.med.utah.edu/WebPath/LABS/LABMENU.html#2

http://www.med.uiuc.edu/PathAtlasf/titlePage.html

http://www.medscape.com/pathologyhome

http://www.gwumc.edu/dept/path/2F.HTM

http://www.path.uiowa.edu/virtualslidebox/

http://web.med.unsw.edu.au/pathology/Pathmus/pathmus.htm#InteractiveImages

http://www.virtualpathology.leeds.ac.uk/

http://histopathsho.34sp.com/index.html

http://pathology.class.kmu.edu.tw/index.htm

http://www.gla.ac.uk/faculties/medicine/teaching/MedCALlist.htm


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Instrumental Analysis

Program (s)in which the course is given: Pharmacy Major or minor element of programmes Department offering the programme: Department of Pharmacy Department offering the course: Academic year/Level: Third year – first semester Date of specification approval: A-BASIC INFORMATION Title: Instrumental Analysis Code: BPH37 Credit hours: 2+1 Lecture: 28 hours Tutorial: within lecture classes Lab.: 13 Total: 41

B-PROFESSIONAL INFORMATION 1- Course Description: The course deals with absorption spectroscopy, instrumentation, colorimetry, quantitative determination of components, also emission spectroscopy including theory of fluorescence, phosphorescence, , instrumentation and applications. Flame spectroscopy including flame emission and atomic absorption.Separation techniques (by chromatography) in addition to electrochemistry containing conductometry, potentiometry and polagrophy. Overall aim of course: Instrumental analysis course aims at introducing the practical and theoretical concepts of modern chromatography and molecular spectroscopy to pharmacy students and enable them to apply these techniques to solve various pharmaceutical problems quantitatively and qualitatively. 2- Intended Learning Outcomes of course (ILOs) A-Knowledge and Understanding: After mastering the concepts of this course, student is expected to be able to:

1- Appreciate the role of chromatography in the development of pharmaceutical industry.

2- Understand the theoretical concept of chromatography 3- Understand the basic principles of HPLC method development validation 4- Understand the connectivity between chromatography and other instrumental

techniques.

B- Intellectual skills: Upon completion of this course, student is expected to be able to:

1- Interpret chromatographic and spectroscopic data obtained in the lab to make a intellectual judgment on the effectiveness of the separation 2- Use mathematical skills to calculate various chromatography parameters


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C- Practical skills:

Upon completion of this course, student is expected to be able to: 1- Use practical chromatography to solve pharmaceutical problems quantitatively and qualitatively. 2- Gain sufficient practical skills to use chromatography instruments and develop various chromatographic methods 3- Use mathematical skills to judge the quality of chromatographic data. 4- Practice instrument calibration, standardization, and unknown identification and quantification 5- Apply extraction concepts practically D- General and Transferable Skills:

Upon completion of this course, student is expected to be able to: 1- Demonstrate critical thinking, problem-solving, and decision making, when dealing with theoretical and practical chemical information in this course. 2- Presentation chemical information and arguments clearly and correctly in writing and orally 3-acquired skills needed for team-working. 4- Perform online computer search to retrieve chemical information from a variety of sources Content:

Hours Topic Week

# 2 Introduction to the course, course syllabus and course policy.

- Classification of Analytical Methods

- Types of Instrumental Methods 2 - Instruments for Analysis - Calibration of Instrumental Methods

- Selecting an Analytical Method

1

2 - Classification of Analytical Methods - Types of Instrumental Methods

- Instruments for Analysis - Calibration of Instrumental Methods

- Selecting an Analytical Method

Note: Ch 1: Skoog et al + Hand out

2


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4 Introduction 1 1.1.1- Introduction to Chromatography 1.1.2 What Is HPLC? / 2 1.1.3 A Brief History / 3 1.1.4 Advantages and Limitations / 4 1.2 Modes of HPLC / 5 1.2.1 Normal-Phase Chromatography (NPC) / 5 1.2.2 Reversed-Phase Chromatography (RPC) / 7 1.2.3 Ion-Exchange Chromatography (IEC) / 7 1.2.4 Size-Exclusion Chromatography (SEC) / 9 1.2.5 Other Separation Modes / 10 1.3 Some Common-Sense Corollaries / 11 1.4 How to Get More Information / 12 Note: ModernHPLC for practing Scientists, Ch. 1

3-4

4 2 Basic Terms and Concepts 15 2.1 Scope / 16 2.2 Basic Terms and Concepts / 17 2.2.1 Retention Time (tR), Void Time (tM), Peak Height (h), and Peak Width (wb) / 17 2.2.2 Retention Volume (VR), Void Volume (VM), and Peak Volume / 18 2.2.3 Retention Factor (k) / 19 2.2.4 Separation Factor (α) / 20 2.2.5 Column Efficiency and Plate Number (N) / 21 2.2.6 Peak Volume / 22 2.2.7 Height Equivalent to a Theoretical Plate or Plate Height (HETP or H) / 23 v 2.2.8 Resolution (Rs) / 23 2.2.9 Peak Symmetry: Asymetry Factor (As) and Tailing Factor (Tf) / 24 2.3 Mobile Phase / 27 2.3.1 General Requirements / 27 2.3.2 Solvent Strength and Selectivity / 28 2.3.3 Buffers / 31 2.3.4 Acidic Mobile Phases / 32 2.3.5 Ion-Pairing Additives / 32 2.3.6 High pH Mobile Phase / 33 2.3.7 Other Operating Parameters: Flow Rate (F) and Column Temperature (T) / 33 2.4 The Resolution Equation / 34 2.5 The Van Deemter Equation / 35 2.6 Isocratic vs. Gradient Analysis / 39 2.6.1 Peak Capacity (n) / 40 2.6.2 Key Gradient Parameters (Initial and Final Solvent Strength, Gradient Time [tG], and Flow Rate) / 41 2.6.3 The 0.25ΔtG Rule:When Is Isocratic Analysis More Appropriate? / 42 2.7 Concept of Orthogonality / 42 2.8 Sample Capacity / 44 2.9 Glossary of HPLC Terms / 44

5-6


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Note: Modern HPLC for Practicing Scientists, Ch 2

2 3 HPLC Columns and Trends 47 3.1 Scope / 48 3.2 General Column Description and Characteristics / 48 3.2.1 Column Hardware—Standard vs. Cartridge Format / 49 3.3 Column Types / 50 3.3.1 Types Based on Chromatographic Modes / 50 3.3.2 Types Based on Dimensions / 51 3.3.3 Column Length (L) / 51 3.4 Column Packing Characteristics / 52 3.4.1 Support Type / 53 3.4.2 Particle Size (dp) / 54 3.4.3 Surface Area and Pore Size (dpore) / 54 3.4.4 Bonding Chemistries / 54 3.4.5 Some General Guidelines for Bonded Phase Selection / 56

Ch: 4 4-HPLC Instrumentation and Trends 77 4.1.2 HPLC Systems and Modules / 79 4.2 HPLC Solvent Delivery Systems / 81 4.2.1 High-Pressure and Low-Pressure Mixing Designs in Multisolvent Pumps / 82 4.2.2 System Dwell Volume / 83 4.2.3 Trends / 84 4.3 Injectors

Note: Modern HPLC for Practicing Scientists, Chs, 3 &4

7

Med Term 8 4 6 Pharmaceutical Analysis 135

6.1 Introduction / 136 6.1.1 Scope / 136 6.1.2 Overview: From Drug Discovery to Quality Control / 136 6.1.3 Sample Preparation Perspectives in Drug Product Analysis / 137 6.1.4 High-Throughput LC/MS in Drug Discovery Support / 137 6.2 Identification / 138 6.3 Assays / 139 6.3.1 Drug Substances / 140 6.3.2 Drug Products / 140 6.3.3 Content Uniformity / 142 6.3.4 Products with Multiple APIs and Natural Products / 142 6.3.5 Assay of Preservatives / 145 6.4 Impurity Testing / 145 6.4.1 Trends in Impurity Testing / 148 6.5 Dissolution Testing / 148 6.6 Cleaning Validation / 148 6.7 Bioanalytical Testing / 150 6.8 Chiral Analysis / 151 6.9 Case Study: HPLC Methods in Early Development / 152

9-10


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Note: Modern HPLC for Practicing Scientists, Ch 6 4 8 HPLC Method Development 193

8.1 Introduction / 194 8.1.1 Scope / 194 8.1.2 Considerations Before Method Development / 194 8.1.3 Strategy for Method Development / 195 x CONTENTS 8.1.4 HPLC Method Development Trends in Pharmaceutical Analysis / 195 8.2 Defining Method Types and Goals / 196 8.2.1 Method Goals / 196 8.3 Gathering Sample and Analyte Information / 197 8.3.1 Defining Sample Preparation Requirements / 197 8.4 Initial HPLC Method Development / 198 8.4.1 Initial Detector Selection / 198 8.4.2 Selection of Chromatographic Mode / 199 8.4.3 Initial Selection of HPLC Column / 199 8.4.4 Generating a First Chromatogram / 200 8.4.4.1 Case Study: Initial Method Development Using a Broad Gradient and Mobile Phase Selection / 200 8.5 Method Fine-Tuning / 204 8.5.1 Mobile Phase Parameters (%B, Buffer, pH, Solvent Type) / 205 8.5.2 Operating Parameters (F, T, Δφ, tG) / 206 8.5.3 Column Parameters (Bonded Phase Type, L, dp, dc) / 206 8.5.4 Detector Setting and Sample Amount / 206 8.5.5 Summary of Method Development Steps / 207 8.6 Phase-Appropriate Method Development / 208 8.7 Method Development Software Tools / 210 8.8 Case Studies / 210 8.8.1 Composite Assay Method for a Neutral Drug Substance / 210 8.8.2 Composite Drug Substance Method for a Basic Drug Substance / 214 8.8.3 Impurity Method for a Drug Product with Two APIs / 215 Note: Modern HPLC for Practicing Scientists, Ch 8

11-12

2 - GC Principles of GLC – - Instruments for GLC - Gas Chromatographic Columns and Stationary Phases - Applications of GC

Note: Skoog et al. Priciples of Instrumental analysis, Ch 27

13

2 Other separation Techniques (CE and CEC) Note: Skoog et al. Principles of Instrumental analysis, Ch 30

14

Major Teaching methodologies: 1- Lectures: Lecturing, cooperative learning, brain storming and group discussion, will be the main teaching methods in this course. Some demonstrations and ICTs will be used when available. 2- Lecture Tools: board, data show, computer, computer animation


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3- Practical sessions (reagents, glassware, HPLC instrument with accessories , UV-Vis Instrument, computer.

4- Written essays (library, internet).

Assessment and Grading: To evaluate the understanding and ability to develop required skills of students, in midterm or final exam. Weighing of assessments:


a First test 20%

b Second test 20%


Make up Exams: There will be no make up exams in this course. University regulations will be followed in the cases where a student misses the final exam. In the cases where a student did not attend a med-term exam or could not hand-in a problem set at due date for a valid reason such as documented illness or death in a family, these cases will be dealt on individual bases.

Text Book: 1-Modern HPLC for practicing scientists, Michael W. Dong, 2006, John Wiley & Sons. 2- Principles of Instrumental analysis, Skoog et al., 7th Ed, 2007 (International Eddition). References: 1-Analytical Chemistry.Gary Christian, 6th Ed, 2004, Jhon Wily and Sons. 2-Modern analytical chemistry, David Harvery, McGraw-Hill Higher Education, 2000. Fundamentals of Analytical Chemistry (with CD-ROM and InfoTrac )by Douglas A. Skoog, Donald M. West, F. James Holler, and Stanley R. Crouch, 8th Ed, 2004


Faculty of Pharmacy


Professional Skills III Programme(s)on which the course is given: Bachelor of Pharmacy Major or minor element of programmes Department offering the programme: NA Department offering the course: Pharmaceutical Sciences Academic year/Level: Third year-First semester Date of specification approval: / / A-BASIC INFORMATION Title: Professional Skills III Code: BPH19 Credit hours: 1 Lecture: 14 hrs Tutorial: within classes Practical: - Total: 14 B-PROFESSIONAL INFORMATION 1-Course Description: This course provides pharmacy students with relevant professional knowledge regarding drug development process, drug information, and medication errors. Overall aim of course: This course aims to prepare the student to utilize, retrieve, interpret and allocate information useful to their practice and in their clinical rotations. The students will be also familiarized with the drug development process and medication errors and how to prevent them. 2-Intended Learning Outcomes of course (ILOs) A-Knowledge and Understanding: The student should be able to:

3. Recognize the drug development process. 4. Describe the different sources of literature. 5. List various sources of medication errors.


3. Demonstrate capabilities of performing literature review. 4. Solve problems regarding obtaining information on various subjects. 5. Anticipate potential elements of errors.

C-Professional and practical skills:


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5. Develop the skills to perform different tasks that require drug information

retrieval. 6. Utilize the available sources of information to optimize a patient – oriented drug

therapy. 7. Integrate the retrieved information toward pharmacist’s major role as the drug

expert in the health care team.

D-General and transferable skills: The student should be able to: d.7 Demonstrate critical thinking, decision making, synthesis and interpretation of

pharmaceutical information, and responsibility. d.8 Obtain required scientific information from available sources. d.9 Develop the ability to work with equations and learn how to choose the simplest

method to carry out pharmaceutical calculations. 3-Contents: Week Topic

1-3 Drug development process

4-10 Drug information

11-14 Medication errors



5-Student assessment method To evaluate the understanding and ability to develop required skills of students, in midterm or final exam.


Faculty of Pharmacy


Weighing of assessments:


a First test 20%

b Second test 20%


6-List of references 6.1-Course notes provided to the students 6.2-Textbooks:

• Text Book Drug Information Handbook

• Supplement (s) Remington. The science and Practice of Pharmacy. 6.3- Websites in international network (internet). 7-Facilities required for teaching and learning Lecture rooms, computers, data show, library, and internet access. Course coordinator: Head of department: Dr. Khaled Al-Tahami


Faculty of Pharmacy


Pharmacology II Programme(s)on which the course is given: Pharmacy Major or minor element of programmes Department offering the programme: Faculty of Pharmacy Department offering the course: Pharmaceutical Sciences Academic year/Level: Third year Date of specification approval: / / A-BASIC INFORMATION Title: Pharmacology II Code: BPH25 Credit hours: 3hrs Lecture: 39 hrs Tutorial: within practical classes Practical: - Total: 39 B-PROFESSIONAL INFORMATION 1-Course Description: This course is dealing with pharmacology of central nervous system, respiratory system, GIT, gout medicines and dermal preparations. Overall aim of course: The scope of the course is to provide students with information about the actions and uses of a number of pharmacologically active drug classes and to explain efficiently the mechanisms by which different members of each class act on their target receptors. 2-Intended Learning Outcomes of course (ILOs) A-Knowledge and Understanding: The student should be able to:

a.5. Understand the principles of neurotransmitters in the brain.

a.6. Distinguish between different groups of drugs acting on CNS

a.7. Recognizing the effect of drugs on respiratory diseases a.8. Distinguish between different types of GIT diseases and drugs acting on them.


b.5 Retrieve the information about excitatory and inhibitory neurotransmitters in the brain. b.6 Evaluate patient’s condition seeking help at the CNS abnormalities and their treatment. b.7 Sort the proper drugs that are acting on different diseases of respiratory system. b.8 Differentiate between agents that acting on GIT diseases. C-Professional and practical skills:


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c.4. Choose the suitable medication for CNS abnormalities according to their pharmacokinetics

and pharmcodynamics c.5. Interpret the cause for choosing the suitable medication for different CNS, RT and GIT

diseases. c.6. Evaluate the gained information during patient counseling to select & provide suitable

drugs for RT and GIT abnormalities. D-General and transferable skills: The student should be able to:

d.10 Demonstrate critical thinking, decision making, synthesis and interpretation of pharmaceutical information, and responsibility.

d.11 Obtain required scientific information from available sources. d.12 Develop the ability to work with equations and learn how to choose the suitable

medications for different ailments.

3-Contents: No. Topic Lectures 1 C.N.S

-Introduction to the pharmacology of CNS drugs -Sedatives –hypnotics -Affective disorders -Antiepileptic agents -Narcotic analgesics -General anesthetic drugs -Neurodegenerative disorders -Ethanol -Skeletal muscle relaxant -Local anaesthetics

10

2 Respiratory system -Cough therapy - Respiratory stimulants & depressants -Bronchial asthma -Antimycobacterium agents

10

3 Gastrointestinal tract -GI secretions & peptic ulceration -Antiemetic drugs -Liver diseases and gallstones

14


Faculty of Pharmacy


-Constipation & laxatives -Diarrhea & antidiarrheal agents -Anthelmintic agents -Amoebiasis& Giardiasis -Inflammatory Bowel disease Seminars -Carminatives -Anorexigenic agents -Appetizers -Digestants

4 Antigout 2

5 Dermatological Pharmacology (Seminars) 3

Total 39

4-Teaching and learning methods Lectures Computer, data show, white board, marker, OHP. Practical Experimental animals, drugs, laboratory chemicals, anesthetics. 5-Student assessment method To evaluate the understanding and ability to develop required skills of students, in midterm or final exam. Weighing of assessments:


a First test 20%

b Second test 20%


6-List of references 6.1-Textbooks: Rang, Dale and Ritter Pharmacology (2009)


Faculty of Pharmacy


Supplements Katzung –Basic and Clinical Pharmacology (2009) 6.3-Websites in international network (internet). 7-Facilities required for teaching and learning Laboratory glassware, chemicals, computers, data show and OHP. Course coordinator: Head of department: Dr. Doa'a Anwar Ibrahim


Faculty of Pharmacy


Pharmaceutical Technology II Programme(s)on which the course is given: Bachelor of Pharmacy Major or minor element of programmes Department offering the programme: NA Department offering the course: Pharmaceutical Sciences Academic year/Level: Third year-Second semester Date of specification approval: / / A-BASIC INFORMATION Title: Pharmaceutical Technology II Code: BPH28 Credit hours: 3 Lecture: 28 hrs Tutorial: within classes Practical: 12 Total: 40 B-PROFESSIONAL INFORMATION 1-Course Description: This course describes the preparation of pharmaceutical dosage forms. It relates the basic scientific background to pharmaceutical practice regarding the dosage forms preparation and quality control. Semi-solid dosage forms, powders and granules, tablets and capsules will be covered. Overall aim of course: The aim of present course is to describe the scientific and technological aspects of the design and manufacture of covered dosage forms. 2-Intended Learning Outcomes of course (ILOs) A-Knowledge and Understanding: The student should be able to:

6. Identify various semi-solid dosage forms, their uses, their manufacturing, and quality copntrol

7. Discuss the different aspects of preparation and labeling of powders, granules, tablets and capsules


6. Compare between different dosage forms and routes of administration. 7. Choose rationally the adjuvants, preparation methods, and equipments of different

formulations.


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C-Professional and practical skills: The student should be able to:

8. Handle chemicals properly and safely. 9. Operate machinery used properly. 10. Collect data from different equipments used. 11. Conduct experiments and analyze results.

D-General and transferable skills: The student should be able to:

d.13 Demonstrate critical thinking, synthesis and interpretation of pharmaceutical information, and responsibility.

d.14 Manage time effectively. d.15 Work effectively as a part of team in order to fulfill certain project. 3-Contents:

Week Topic

1-5

Semisolid dosage forms: • Ointments • Creams • Gels • Pastes • Suppositories

6 Powders and granules

7-10 Tablets

11-14 Capsules

Practical Part: Week Experiment 1 Semisolid dosage forms I 2 Semisolid dosage forms II 3 Semisolid dosage forms III 4 Semisolid dosage forms IV 5 Semisolid dosage forms V


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6 Powders and granules I 7 Powders and granules II 8 Tablets I 9 Tablets II 10 Coating of Tablets 11 Capsules 12 Capsules 4-Teaching and learning methods




a First test 15%

b Second test 15%

c Activities 5%

d Final test 35%


Total 100% 6-List of references 6.1-Course notes provided to the students 6.2-Textbooks:

• Text Book: Pharmaceutical dosage forms and drug delivery systems ( HowardAnsel, Loyd Allen, Nicholas Popovich)

• Supplement (s)


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4- Pharmaceutics: the science of dosage form design (M.E. Aulton) 5- The Theory and Practice of Industrial Pharmacy (Lanchman, L., Lieberman, H.,

and Kanig, J.) 6- Remington: The Science and Practice of Pharmacy

6.3- Websites in international network (internet). 7-Facilities required for teaching and learning Lecture rooms, computers, data show, library, and internet access. Course coordinator: Head of department: Dr. Khaled Al-Tahami


Faculty of Pharmacy


Pharmaceutical Chemistry II

Program (s)in which the course is given: Bachelor of Pharmacy Major or minor element of programmes Department offering the programme: Pharmacy Department offering the course: Pharmacy Academic year/Level: Third year- Second Semester Date of specification approval: A-BASIC INFORMATION Title: Pharmaceutical chemistry II Code: BPH31 Credit hours: 2 Lecture: 28 hours Tutorial: within lecture classes Practical: Total: 28



This course describes thephysico chemical properties of drugs and drug action, including

receptorsite theories, the synthesis and structure-activity relationships of some classes of

pharmacodynamic agents. The course also comprises study of chemotherapeutic agents.

Overall aim of course:

Get knowledge about the chemistry of drugs.

2- Intended learning outcomes of course (ILOs)

A- Knowledge and understanding:


a.1. Understand the basic background of the pharmacology and the chemical

structures of drugs.

a.2. Understand the general metabolic pathways of drugs.

a.3. Understand the chemical synthesis of selected drugs.

a.4. Understand the structure-activity relationship (SAR) of drugs.

B- Intellectual skills:


b.1 Discuss and analyze the basic structures of therapeutic groups

b.2 Discuss and analyze the main metabolic pathways of drugs.

C- Professional and practical skills:


c.1 Guess the pharmacological activity of drugs, based on the structure-activity

relationship (SAR).


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c.2 Working in factories, pharmaceutical companies, and other health facilities, in

the field of new drugs design, and quantitative and qualitative determination of

drugs.

D- General and transferable skills:

At the end of the course the student should be aware about:

d.1 The importance of continuous self-study of drugs

d.2 Coordinate the basic and the practical knowledge of drugs

3- Contents

Lectures:

No. Title Hours

1 Angina, nitrates 2

2 Arrhythmia, calcium channel blockers 2

3 Hypertension, ACEI, vasodilators 2

4 Hyperlipidemia, resins, fibrates, statins 2

5 Anticoagulants, coumarins, indandiones 2

6 Hypoglycemic agents, sulfonylureas, biguanides 2

7 Meglitinides, glucosidase inhibitors, others 2

8 β-lactam antibiotics 2

9 tetracyclines, macrolides 2

10 sulfonamides, quinolones 2

11 Antiprotozoal 2

12 Antifungal 2

13 Antiviral 2

14 Anticancer 2

Total 28


Lectures

Computer, data show, white board, marker.

Practical

Laboratory of chemistry.


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5- Student assessment method

To evaluate the understanding and ability to develop required skills of students, in midterm or final exam. Weighing of assessments:


a First test 15%

b Second test 15%

c Activities 5%

d Final test 35%


Total 100%

6- References

Testbook:

• John H Block and John M Beale Jr., Wilson and Gisvold’s Textbook of Organic,

Medicinal and Pharmaceutical Chemistry, 2004, 11th Edition, Lippincott Williams &

Wilkins.

Supplement:

• Adel Nofal, Pharmaceutical Chemistry, DamascusUniversity Publications, 2007, 3rd

Edition. (Arabic book)

7- Facilities required for teaching and learning

White board, data show, textbooks and laboratory.

Course coordinator:

Head of departement:


Faculty of Pharmacy


Phytochemistry II

A-Basic Information Title: Phytochemistry II Code: BPH34 Credit Hours:3 hrs/ week Lecture: Lecture: 2 hrs/week/semester Tutorial: within practical classes Practical: 1hr/week/semester B-Professional Information

Course Description: This course describes the study of plants constituents not included in Phytochemistry I. It includes other methods used for isolation of plant constituents. Official standards and microanalysis are included. It also includes study of principles of different chromatographic methods as tools for isolation and analysis of medicinal constituents. Overall aim of course: A- Giving knowledge about the main active constituents present in medicinal plants and responsible for the therapeutic actions. B- Classification of the main active constituents according to their structures. C- Giving an idea about different methods used for isolation of the different groups of the active constituents. D- Identification and determination of the main active constituents using different methods including physical, chemical and chromatographyical methods. E- Giving an idea about the main uses of different group of compounds, abuses, side effects and toxic effects

Intended Learning Outcomes of Course(ILOs)

a-Knowledge and Understanding :

1. The concepts of chemistry of biologically active natural products as glycosides, alkaloids, volatile oil, bitter principle, tannin and lignan.

2. To acquire knowledge about the main active constituents present in the herbal drugs and natural products, their actions, side effects and toxicity

3. To acquire a knowledge about the different methods for isolation, identification of these active constituents

4. To get a skill about the prescription of these ingredients for treatment of different ailments.

5. To get a knowledge about the recent research articles and advanced studies on these compounds concerning their modern uses.

6. Principles of isolation, bio-synthesis, purification, identification and standardization methods of biologically active compounds.

b-Intellectual Skills

1. The student can classify the active constituents according to their therapeutic uses


Faculty of Pharmacy


2. The student can choose the best methods for isolation and identification of the different group of compounds according to their chemical character.

3. Differentiate between the different compound in the same group using different methods.

c- Professional and practical Skills

1. To acquire skills to isolate and identify the different groups of the active constituents.

2. Skill to prescribe the suitable drugs according to their mode of action. 3. Acquire skills to decrease the side effects of some drugs.

d- General and Transferable Skills 1. Communication skills 2. Skill to use different methods for identification of natural drugs 3. Writing reports for criticizing natural compounds

4- Contents

NO. of hours subject

٣ Cyanogenetic, glycosinolate and Bitter principle

Lecture 1 ١

٣ Lignin and lignan and Tannins Lecture 2 ٢

٣ Flavonoids Lecture 3 ٣

٣ Volatile oil Lecture 4 ٤

٣ Volatile oil Lecture 5 ٥

٣ Midterm examination Lecture 6 ٦

٣ Alkaloids Lecture 7 ٧

٣ Alkaloids Lecture 8 ٨

٣ Alkaloids Lecture 9 ٩

٣ Alkaloids Lecture 10 ١٠

3 Alkaloids Lecture 11 11

3 Alkaloids Lecture 12 12


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4- 4- Teaching and Learning Methods 4.1-OHP 4.2- Data show 4.3- White board, marker 4.4-Computer Practical: Laboratory chemicals, water bathes, glass wares 5- Student Assessment Methods To evaluate the understanding and ability to develop required skills of students, in midterm or final exam. Weighing of assessments:

subject Column chromatography lab 1 ١

TLC chromatography lab 2 ٢

Paper chromatography lab 3 ٣

Terpenoids lab 4 ٤

Cardiac glycosides lab 5 ٥

Anthraquinone lab 6 ٦

Saopnin lab 7 ٧

Cyanogenetic, glycosinolate lab 8 ٨

Flavonoids and Tannins lab 9 ٩

Volatile oil lab 10 ١٠

Alkaloids lab 11 11

Alkaloids lab 12 12


Faculty of Pharmacy



a First test 15%

b Second test 15%

c Activities 5%

d Final test 35%


Total 100% 6- List of References Textbook

Trease G. E. and Evan W. C. " Pharmacognosy", 2002. Supplements:

1- Balbaa,S., et. al. "Chemistry of Natural Products", 1976 2- -Balbaa,S., et. al. Practical Notebook in "Chemistry of Natural Products", 1976.

7- Facilities Required for Teaching and Learning Chemicals, glass wears, computer, data show, OHP. Head of Department:


Faculty of Pharmacy


Pharmaceutical Microbiology

A- Basic Information

Title: Pharmaceutical Microbiology Code:BPH38 Credit hours: 2+1

Lectures: 28 hrsPractical: 13 hrsTotal: 41 hrs

Program(s) in which the course is given:Bachelor of Pharmacy

Department offering the course:Microbiology

Academic year/Level:Third year – second semester



The course deals with the role of microorganisms in infectious disease. The study includes the causative agent, its general characteristics, pathogenicity, clinical symptoms, laboratory diagnosis, prevention and control, and the treatment of different infections. The course also covers chemotherapy of infectious diseases, sterilization by physical and chemical methods and its application in pharmacy. Preservation and testing preservative efficiency.Evaluation of antimicrobial agents. Overall Aims of Course: a. Highlighting major infections by organ system. b. Introducing principles of immunization, vaccination, antimicrobial therapy infection/contamination control within a pharmacological context. c. Familiarization with microbiological tests used in quality assurance of pharmaceutical products. d. Introducing important biotechnologies including molecular techniques with relevance to pharmacology.

2- Intended Learning Outcomes of course (ILOs)

a. Knowledge and Understanding:

a.1 Ability to enumerate major bacterial, viral and fungal infections in humans and to describe immunization strategies against them.

a.2 Ability to account for classes of antimicrobial agents, their mechanism of action and indications/contraindications.

a.3 Ability to describe principles of infection/contamination control and enumerate disinfectants and sterilization techniques.

a.4 Ability to describe tests used in assessment of sterile formulations, antimicrobials, antiseptics, disinfectants, and sterilization procedures.

a.5 Ability to account for major biotechnologies used in drug discovery, production, delivery and assessment.

b. Intellectual and practical skills:

b.1 Ability to differentiate between bacterial, viral and fungal infections within a pharmacological context.


Faculty of Pharmacy


b.2 Ability to identify contamination sources and to select appropriate disinfection/sterilization techniques and to monitor their performance.

b.3 Ability to request, perform, and interpret tests of antimicrobial agents and microbiological assessment of pharmaceutical formulae.

b.4 Ability to illustrate examples of biotechnologies used in the field of pharmacology.

c. General and transferable skills:

c.1 Communication c.2 Developing an independent approach to acquiring knowledge c.3 Reading and searching the literature c.4 Taking responsibility of own work

3- Contents:

• Lectures

No. Topic Hours

1 Respiratory infections 3 2 Hepatitis viruses 2 3 Retroviruses 2 4 Infective endocarditis and sepsis syndrom 2 5 Genitourinary tract infections 2

6 Soft tissue infections – GIT infections 2 7 Immunization 2 8 Antimicrobial agents 3 9 Antiseptics, disinfectants and sterilization 2

10 Testing of antimicrobial agents, antiseptics, disinfectants and sterilization 2

11 Sterile preparations, infection/contamination control – clean rooms 2 12 Biotechnologies I: hybrodomas – introduction to molecular techniques 2

13 Biotechnologies II: PCR, recombinant DNA technologies, gene therapy. 2

Total ٢٨ • Practical

No. Topic Hours

1 Isolation and identification of pathogens from GIT infections ٢

2 Isolation and identification of pathogens from respiratory tract infections ٢

3 Antimicrobial sensitivity testing ٢

4 Assessment of antimicrobial agents, antiseptics, disinfectants and sterilization ٢

5 Microbiological testing of raw materials and pharmaceutical preparations ٢

6 Assessment of clean rooms (filters – particle counters) ١


Faculty of Pharmacy


7 DNA/RNA extraction and gel electrophoresis ١ 8 PCR and real-time PCR ١

Total ١٣ 4- Teaching and learning methods

• Lectures: PowerPoint presentations, animations, and videos • Practical: Gram-stain, culture media, reference bacterial strains, biochemical tests,

immunological reagents, incubators, microscopes, antibiotic discs, sterilization monitoring indictors, particle counter and molecular biology equipment and reagents.

5- Student assessment

To evaluate the understanding and ability to develop required skills of students, in midterm or final exam. Weighing of assessments:


a First test 15%

b Second test 15%

c Activities 5%

d Final test 35%


Total 100%

6- List of references

a. Course notes (lecture notes and practical notes) prepared by staff members b. Required Textbook: Hugo and Russel’s pharmaceutical microbiology, 7th ed.

Blackwell publishing c. Supplementary reading: Pharmaceutical Microbiology: principles and applications;

Kokare. Course coordinator


Faculty of Pharmacy


Pathophysiology I

University: Science & Technology Faculty: Pharmacy Programme(s)on which the course is given: Pharmacy Major or minor element of programmes Department offering the programme: Department offering the course: Pathophysiology I Academic year/Level: Third year – second semester Date of specification approval: / / A-BASIC INFORMATION Title: Pathophysiology I Code: BPH39 Credit hours:2 Lecture: 28hrs Total:28hrs B-PROFESSIONAL INFORMATION 1-Course Description: This course serves to prepare students for consequent therapeutics courses through introducing the pharmacy students to mechanisms of diseases in several human body systems. Overall aim of course: The scope of the course is to introduce the pharmacy students to the pathogenesis of various symptoms & diseases affecting the GIT, CVS and endocrine systems. Altered, physiological functions of human organs are explained and, then described on molecular, cellular, organ & systemic level. 2-Intended Learning Outcomes of course (ILOs) A-Knowledge and Understanding: The student should be able to: a.1. Discuss the etiology, pathogenesis, morphology, local & systemic effects of cell injury due to diseases affecting some major organs like cardiovascular system

a.2. Explain the underlying causes of diabetes and disorders of thyroid gland. a.3. Discuss the etiology and manifestations of peptic ulcer and GERD B-Intellectual skills: The student should be able to:

b.1.Differentiate between the different ailments based on their pathophysiology backgrounds


Faculty of Pharmacy


b.2. Recognize the importance of paathophysiology in identification of different diseases.

b.3. Assume individual responsibility and accountability in the role of provider of care and manager of care in the application of pathophysiological mechanisms of disease to client care. C-Professional and practical skills: The student should be able to:

c.1. Apply principles of immunology & basic physiological processes to systemic disease states.

c.2. Evaluate pharmacy research using physiological measurements as a basis for evidenced-based practice

c.3. Participate in discussions about the causes and dynamics of diseases with the knowledge of recent scientific information

D-General and transferable skills: The student should be able to: d.1.Solve problems and work effectively and independently; b.2.Utilise library and computer resources effectively to access and search for information in specified areas, from a range of sources; b.3. Demonstrate competency skills in the role of self-reflection and goal-setting in personal performance and development. B.4. Critically examines the importance of the resources needed to effectively received data 3-Contents:

No. Topic Lectures 1 Mechanisms of Disease 2 2 Tissue Adaptationand Injury and inflammation 2 3 Gastrointestinal diseases 2 4 Alterations in the Cardiovascular System

i-Alterations in Blood Pressure ii-Alteration in cardiac function -Coronary Heart Disease -Myocardial and Endocardial Disease

4

5 Alterations in the Endocrine System i-Alterations in Pituitary, Thyroid, Parathyroid, and Adrenal Function ii-Diabetes Mellitus

2


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٦ Alterations in Skin Function and Integrity

2

Total 14

4-Teaching and learning methods Lectures Computer, data show, white board, marker, OHP. 5-Student assessment method To evaluate the understanding and ability to develop required skills of students, in midterm or final exam. Weighing of assessments:


a First test 20%

b Second test 20%


6-List of references 6.1-Textbooks: Textbook: Mattson, K. (February 1, 2006). Essential of Pathophysiology.Concepts of Altered Health States.2nd edition. Lippincott Williams & Wilkins; ISBN-10: 0781770874 Supplements:

• Porth C. “1998” Pathophysiology. Concepts of Altered Health States. 5th edition. Lippincott- Raven Publishers. New York

• Huether S. “2004” Understanding Pathophysiology. 3rd edition. Mosby. USA.

6.3-Websites in international network (internet). Course coordinator: Head of department:


Faculty of Pharmacy


Nutrition

Programme(s)on which the course is given: Bachelor of Pharmacy Major or minor element of programmes Faculty offering the programme: Pharmacy Department offering the course: Pharmaceutical Sciences Academic year/Level: Third year- Second semester Date of specification approval: / / A-BASIC INFORMATION Title: Nutrition Code: BPH41 Credit hours: 2 Lecture: 28 hrs Tutorial: within classes Practical: - Total: 28 B-PROFESSIONAL INFORMATION 1-Course Description: This course covers several selected nutrition topics important for pharmacy practice. Overall aim of course: This course is designed to help the student integrate both the clinical & basic scientific knowledge ofpharmacy practice with nutrition issues that will be faced in the clinical setting.During the semester, students will be exposed to basic nutrition information, disease specific nutritionalissues and the research surrounding these issues. Although this is primarily a lecture-based course, interaction and participation by each student is highlyencouraged. 2-Intended Learning Outcomes of course (ILOs) The learners who successfully complete this course should be able to: 1. Understand nutritional terminology, dietary requirements, and the role of nutrients in health and disease states. 2. Understand the application of various tools for nutritional assessment, nutritional deficiencies and toxicities, and principles of functional food regulations, food safety and food processing technologies 3. Explain the interrelation of the biochemical, pharmacological and physiological functions of nutrients. 4. Explain how dietary agents (functional foods and nutraceuticals) may prevent or delay the onset of some chronic diseases. 5. Discuss the criteria of an adequate diet for healthy individuals at various life cycles. 6. Search and report on a topic of relevance to nutrition and health.


Faculty of Pharmacy


3-Contents: No Topic Theoretical Practical 1 Introductions, syllabus, overview 2 - 2 Introduction to Human Nutrition and Nutritional

Terminology Basic info on micro- and macro- nutrients, their role in human health, major dietary sources, units and conversion,

2 -

3 Energy balance/weight management, body composition

2

4 Basic Nutrition During Pregnancy Review of major physiological changes during pregnancy, 3 trimesters, importance of BW gain and BMIenergy requirements, macro and micro nutrient requirements, some common pregnancy related problems and their effects on nutrient net intake as well as their dietary managements

4 -

5 Basic Nutrition during lactation Review of milk production/ejection, factors affecting these processes, human milk composition, major differences between cow’s milk and human milk, the impact of certain drugs on lactation

4 -

6 Lifestyle, drug/diet interactions 4 - 7 Dietary agents with cholesterol-lowering efficacy 2 - 8 Dietary management of Obesity, Atherosclerosis,

Diabetes and Cancer 4 -

9 Dietary management of GI, Renal, Respiratory and CNS disorders

4 -


• Lectures (Tools: board, overhead projector, pc and data- show projector). • Assignments (journal club discussions).



a First test 20%


Faculty of Pharmacy


b Second test 20%


6-List of references Textbook:

• DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM, editors. Pharmacotherapy: apathophysiologic approach. 6th ed. New York: McGraw-Hill; 2005.

Supplements: • Rolfes SR, Pinna K, Whitney E, editors. Understanding normal and clinical nutrition.

7th ed.Belmont CA: Thompson Wadsworth; 2006. • Krause’s Food, Nutrition and Diet Therapy 12th Edition, 2008 • Nutrition through the Life Cycle. Judith E. Brown, 4th edition 2011 • Nutrition Concepts and Controversies, 2nd Canadian edition 2011 • Nutrient-Drug Interactions, Meckling KA. 2007

7-Facilities required for teaching and learning Lecture rooms, computers, data show, library, and internet access. Course coordinator: Head of department:


Faculty of Pharmacy


Professional Skills IV

Program (s)in which the course is given: Bachelor of Pharmacy Major or minor element of programmes Department offering the programme: Pharmacy Department offering the course: Pharmacy Academic year/Level: Third year- Second Semester Date of specification approval: A-BASIC INFORMATION Title: professional skill IV Code: BPH20 Credit hours1 Lecture: 14 hours Tutorial: within lecture classes Practical: Total: 14

B-Professional Information

1) –Course Description: This course provides a strong introduction to the principles and practices of effective internship protocols, professionalism and employment strategies Overall aim of course: Students is excepted to gain proficiency in business communication skills, professionalism and presentation skills.

-Intended Learning Outcomes (ILOs): -)2

a- Knowledge and understanding: The student should be able to: a1- Explain and describe the process of communication a2- explore the dynamics of interpersonal communication across a range of contexts a3- explore and describe the communicating with patients, professional and ethical behavior, history taking and patient respect a4- Demonstrate correct client care and professionalism at all times

b- Intellectual skills: At the end of this course the student should be able to: b1- examine problem-solving and decision-making strategies b2- examine the dynamics of communication within groups and within organizations

C- Professional and practical skills: At the end of the course, the student should be able to: c1- identify a range of interpersonal communication strategies to minimise barriers to effective communication.


Faculty of Pharmacy


C2- demonstrate ethical research and inquiry skills by analysing and developing a given task, conducting a targeted literature review, and identifying and applying referencing principles using an accepted referencing system;

C3- Identify behaviors and factors related to health and attitudes that may jeopardize a student’s success

d- General and transferable skills The student should be able to: d1-Communications d2-Professionalism and ethics d3-Interact effectively with individuals and groups.

:Contents)3

Lecture:

Lecture No. of hours

Topic No

٢ ٢ 7 core skills, verbal, non-verbal, empathy ١ 2 2 Professionalism ٢ ٣ ٣ Interpersonal communication ٣ ١ ١ Patient interview ٤ ١ ١ Patient assessment ٥ ٢ ٢ Evaluation of information ٦ ٢ ٢ Role playing ٧ ١ ١ Presentation skills ٨ 14 14 Total

4) Teaching & learning methods: 1-Lectures, (Tools: board, overhead projector, data show).

5-Student assessment methods: To evaluate the understanding and ability to develop required skills of students, in midterm or final exam. Weighing of assessments:


a First test 20%

b Second test 20%


Faculty of Pharmacy



6) List of references:-

-Course notes 6-1-Course Lecture and practical notes prepared by instructor 6.2- Essential books ((text books)

1.Professionalism, Work, and Clinical Responsibility in Pharmacy, Author(s): David Tipton,

Associate Professor of Pharmaceutical 6.3- Recommended books:

2.Communication Skills in Pharmacy Practice: A Practical Guide for Students and Practitioners 7) Facilities required for teaching and learning: - Computer, data show, OHP. -

Course coordinator: Dr. Gamil AL-Thobhany

Date: 25/12 /2012

Documents

Third Year : First Semester - ust.eduust.edu/img/مواد المستوى الثالث.pdf · Department offering the programme: Faculty of Pharmacy Department offering the course: