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Review Statin Treatment and New-Onset Diabetes: A Review of Proposed Mechanisms Marilyne Brault, Jessica Ray, Yessica-Haydee Gomez, Christos S. Mantzoros, and Stella S. Daskalopoulou 735 Clinical Science Cotreatment With the -Glucosidase Inhibitor Miglitol and DPP-4 Inhibitor Sitagliptin Improves Glycemic Control and Reduces the Expressions of CVD Risk Factors in Type 2 Diabetic Japanese Patients Chihiro Imai, Miyoko Saito, Kazuki Mochizuki, Masahiro Fuchigami, Toshinao Goda, and Takeshi Osonoi 746 Circulating Fetuin-A Levels Are Not Affected by Short and Long-Term Energy Deprivation and/or by Leptin Administration Janice J. Hwang, Bindiya Thakkar, John P. Chamberland, and Christos S. Mantzoros 754 Chemerin Levels as Predictor of Acute Coronary Events: A Case–Control Study Nested Within the Veterans Affairs Normative Aging Study Konstantinos N. Aronis, Ayse Sahin-Efe, John P. Chamberland, Avron Spiro III, Pantel Vokonas, and Christos S. Mantzoros 760 Glucoregulatory Function Among African Americans and European Americans With Normal or Pre-Diabetic Hemoglobin A1c Levels Sotonte Ebenibo, Chimaroke Edeoga, Jim Wan, and Samuel Dagogo-Jack 767 Circulating Alanine Transaminase (ALT) and -Glutamyl Transferase (GGT), But Not Fetuin-A, Are Associated With Metabolic Risk Factors, at Baseline and at Two-Year Follow-Up: The Prospective Cyprus Metabolism Study Xiaowen Liu, Ole-Petter R. Hamnvik, John P. Chamberland, Michael Petrou, Huizhi Gong, Costas A. Christophi, David C. Christiani, Stefanos N. Kales, and Christos S. Mantzoros 773 Immunologic and Mass-Spectrometric Estimates of SHBG Concentrations in Healthy Women Johannes D. Veldhuis, Roy B. Dyer, Sergey A. Trushin, Olga P. Bondar, Ravinder J. Singh, and George G. Klee 783 Basic Science Anti-Obesity Effects of KR-66195, a Synthetic DPP-IV Inhibitor, in Diet-Induced Obese Mice and Obese-Diabetic ob/ob Mice Eun Young Lee, Yeon Wook Kim, Hyunhee Oh, Cheol Soo Choi, Jin Hee Ahn, Byung-Wan Lee, Eun Seok Kang, Bong Soo Cha, and Hyun Chul Lee 793 Glucagon-Like Peptide-1 Production in the GLUTag Cell Line Is Impaired by Free Fatty Acids Via Endoplasmic Reticulum Stress Hiroto Hayashi, Ren Yamada, Siddhartha Shankar Das, Taiki Sato, Aki Takahashi, Masahiro Hiratsuka, and Noriyasu Hirasawa 800 TSH Signaling Pathways that Regulate MCP-1 in Human Differentiated Adipocytes AnneMarie Gagnon, Melanie L. Langille, Seham Chaker, Tayze T. Antunes, Jason Durand, and Alexander Sorisky 812 TRIB3 Alters Endoplasmic Reticulum Stress-Induced ß-Cell Apoptosis Via the NF- B Pathway Ni Fang, Wenjian Zhang, Shiqing Xu, Hua Lin, Zai Wang, Honglin Liu, Qing Fang, Chenghui Li, Liang Peng, and Jinning Lou 822 (Continued on following page) Vol 63, No 6, June 2014 CONTENTS

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ReviewStatin Treatment and New-Onset Diabetes: A Review of Proposed Mechanisms

Marilyne Brault, Jessica Ray, Yessica-Haydee Gomez, Christos S. Mantzoros, and Stella S. Daskalopoulou 735

Clinical ScienceCotreatment With the -Glucosidase Inhibitor Miglitol and DPP-4 Inhibitor Sitagliptin Improves Glycemic Control and Reduces the Expressions of CVD Risk Factors in Type 2 Diabetic Japanese Patients

Chihiro Imai, Miyoko Saito, Kazuki Mochizuki, Masahiro Fuchigami, Toshinao Goda, and Takeshi Osonoi 746

Circulating Fetuin-A Levels Are Not Affected by Short and Long-Term Energy Deprivation and/or byLeptin Administration

Janice J. Hwang, Bindiya Thakkar, John P. Chamberland, and Christos S. Mantzoros 754

Chemerin Levels as Predictor of Acute Coronary Events: A Case–Control Study Nested Within theVeterans Affairs Normative Aging Study

Konstantinos N. Aronis, Ayse Sahin-Efe, John P. Chamberland, Avron Spiro III, Pantel Vokonas,and Christos S. Mantzoros 760

Glucoregulatory Function Among African Americans and European Americans With Normal orPre-Diabetic Hemoglobin A1c Levels

Sotonte Ebenibo, Chimaroke Edeoga, Jim Wan, and Samuel Dagogo-Jack 767

Circulating Alanine Transaminase (ALT) and -Glutamyl Transferase (GGT), But Not Fetuin-A, Are Associated With Metabolic Risk Factors, at Baseline and at Two-Year Follow-Up: The ProspectiveCyprus Metabolism Study

Xiaowen Liu, Ole-Petter R. Hamnvik, John P. Chamberland, Michael Petrou, Huizhi Gong, Costas A. Christophi,David C. Christiani, Stefanos N. Kales, and Christos S. Mantzoros 773

Immunologic and Mass-Spectrometric Estimates of SHBG Concentrations in Healthy WomenJohannes D. Veldhuis, Roy B. Dyer, Sergey A. Trushin, Olga P. Bondar, Ravinder J. Singh, and George G. Klee 783

Basic ScienceAnti-Obesity Effects of KR-66195, a Synthetic DPP-IV Inhibitor, in Diet-Induced Obese Miceand Obese-Diabetic ob/ob Mice

Eun Young Lee, Yeon Wook Kim, Hyunhee Oh, Cheol Soo Choi, Jin Hee Ahn, Byung-Wan Lee, Eun Seok Kang,Bong Soo Cha, and Hyun Chul Lee 793

Glucagon-Like Peptide-1 Production in the GLUTag Cell Line Is Impaired by Free Fatty Acids Via Endoplasmic Reticulum Stress

Hiroto Hayashi, Ren Yamada, Siddhartha Shankar Das, Taiki Sato, Aki Takahashi, Masahiro Hiratsuka,and Noriyasu Hirasawa 800

TSH Signaling Pathways that Regulate MCP-1 in Human Differentiated AdipocytesAnneMarie Gagnon, Melanie L. Langille, Seham Chaker, Tayze T. Antunes, Jason Durand,and Alexander Sorisky 812

TRIB3 Alters Endoplasmic Reticulum Stress-Induced ß-Cell Apoptosis Via the NF- B PathwayNi Fang, Wenjian Zhang, Shiqing Xu, Hua Lin, Zai Wang, Honglin Liu, Qing Fang, Chenghui Li,Liang Peng, and Jinning Lou 822

(Continued on following page)

Vol 63, No 6, June 2014

CONTENTS

Articles in this journal are listed in Index Medicus/MEDLINE, ISI/SCI Current Contents/Life Sciences, EMBASE/Excerpta Medica, and BIOSIS.

(Contents continued)Superantigen Activates the gp130 Receptor on Adipocytes Resulting in Altered Adipocyte Metabolism

Elin Banke, Karin Rödström, Mikael Ekelund, Jonathan Dalla-Riva, Jens O. Lagerstedt, Staffan Nilsson,Eva Degerman, Karin Lindkvist-Petersson, and Bo Nilson 831

Effects of Individual Branched-Chain Amino Acids Deprivation on Insulin Sensitivity and Glucose Metabolism in Mice

Fei Xiao, Junjie Yu, Yajie Guo, Jiali Deng, Kai Li, Ying Du, Shanghai Chen, Jianmin Zhu,Hongguang Sheng, and Feifan Guo 841

Estrogen Restores Brain Insulin Sensitivity in Ovariectomized Non-Obese Rats, But Not inOvariectomized Obese Rats

Wasana Pratchayasakul, Nipon Chattipakorn, and Siriporn C. Chattipakorn 851

TranslationalMarkers of Endothelial Cell Dysfunction Are Increased in Human Omental Adipose Tissue FromWomen With Pre-Existing Maternal Obesity and Gestational Diabetes

Martha Lappas 860

ErratumMitochondrial Regulators of Fatty Acid Metabolism Reflect Metabolic Dysfunction in Type 2 Diabetes, Kulkarni et al., Metabolism, 61(2):175–85 e9