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    Part 2: Recommendations for

    Hypertension Treatment

    2012 Canadian Hypertension

    Education ProgramRecommendations

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    The full slide set of the2012 CHEP Recommendations

    is available at

    www.hypertension.ca

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    2012 Canadian Hypertension EducationProgram (CHEP)

    A red flag has been posted whererecommendations were updated for 2012.

    Slide kits for health care professional and publiceducation can be downloaded (English and Frenchversions) from www.hypertension.ca

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    Key CHEP Messages for theManagement of Hypertension

    1. Assess blood pressure at all appropriate visits.

    2. Maintaining a healthy lifestyle and weight lowers blood pressureand prevents hypertension. Promote: smoking cessation, healthydiet reducing dietary sodium and increased physical activity.

    3. Lower blood pressure to

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    CHEP 2012 Recommendations

    Whats new?

    Out-of-office blood pressure measurements areimportant in both the diagnosis and management of

    hypertension For patients with nondiabetic chronic kidney disease,

    target blood pressure should be < 140/90 mmHg

    For patients with systolic dysfunction and hypertension

    ACE inhibitors, beta-blockers and (for most)aldosterone antagonists are recommended

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    For your patients ask themto sign up atwww.myBPsite.ca for freeaccess to the latest

    information & resources onhigh blood pressure

    For health care professionals sign up atwww.hypertension.ca forautomatic updates and

    information on currenthypertension educationalresources

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    The Canadian Hypertension EducationProgram: 2012 Recommendations

    Whats still important?

    Lifestyle changes are a critical component ofhypertension management and prevention

    The most important step in prescription ofantihypertensive therapy is achieving patient buy-in

    Single pill combinations help achieve blood pressurecontrol

    The management of hypertension is all about globalcardiovascular risk management and vascularprotection

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    2012 Canadian Hypertension EducationProgram (CHEP)

    Treatment Approaches:

    Lifestyle

    Pharmacological

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    Recommendations 2012Table of contents

    I. Lifestyle ManagementII. Indications for drug therapyIII. Choice of therapyIV. Global vascular protectionV. Goal of therapy

    VI. CV IHDVII. CHF

    VIII. Cerebrovascular / StrokeIX. LVHX. Chronic kidney disease

    XI. RenovascularXII. DiabetesXIII. Adherence strategies for patientsXIV.Endocrine

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    I. Lifestyle management

    2012 Canadian Hypertension

    Education ProgramRecommendations

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    Lifestyle Recommendations forPrevention andTreatment of Hypertension

    To reduce the possibility of becoming hypertensive,

    Reduce sodium intake to less than 1500 mg/day

    Healthy diet: high in fresh fruits, vegetables, low fat dairy products,dietary and soluble fibre, whole grains and protein from plant sources,low in saturated fat, cholesterol and salt in accordance with Canada'sGuide to Healthy Eating.

    Regular physical activity: accumulation of 30-60 minutes of moderateintensity dynamic exercise 4-7 days per week in addition to dailyactivities

    Low risk alcohol consumption: (2 standard drinks/day and lessthan 14/week for men and less than 9/week for women)

    Attaining and maintaining ideal body weight (BMI 18.5-24.9 kg/m2)

    Waist Circumference: Men

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    Dietary Sodium

    Less than 2300mg / day

    (Most of the salt in food is hidden and comesfrom processed food)

    Dietary Potassium

    Daily dietary intake >80 mmol

    Calcium supplementation

    No conclusive studies for hypertension

    Magnesium supplementation

    No conclusive studies for hypertension

    Lifestyle Recommendations for Hypertension:Dietary

    High in: Fresh fruits Fresh vegetables

    Low fat dairy products Dietary and soluble fibre Plant protein

    Low in:

    Saturated fat and cholesterol Sodium

    www.hc-sc.gc.ca/fn-an/food-guide-aliment/index-eng.php.

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    Potential Benefits of a Wide Spread Reductionin Dietary Sodium in Canada

    1 million fewer hypertensives

    5 million fewer physicians visits a year for hypertension Health care cost savings of $430 to 540 million per year related

    to fewer office visits, drugs and laboratory costs for hypertension

    Improvement of the hypertension treatment and control rate

    13% reduction in CVD

    Total health care cost savings of over $1.3 billion/year

    1. Penz ED, Cdn J Cardiol 2008.2. Joffres MR_CJC_ 23(6) 2007.

    Reduction in average dietary sodium from about3500 mg to 1700 mg1,2

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    Recommendations for adequate daily sodium intake

    2,300 mg sodium (Na)

    = 100 mmol sodium (Na)

    = 5.8 g of salt (NaCl)

    = 1 level teaspoon of

    table salt

    80% of average sodium intake is in processed foods

    Only 10% is added at the table or in cooking

    Age Adequate

    Intake

    (mg)

    Upper

    Limit

    (mg)

    19-50 1500 2300

    51-70 1300 2300

    71 and

    over

    1200 2300

    Institute of Medicine, 2003

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    Sodium: Meta-analyses

    The Cochrane Library2006;3:1-41

    Average Reduction of sodiumin mg/day

    1800 mg/day

    2300 mg/day

    Hypertensives

    Reduction of BP

    5.1 / 2.7 mmHg

    7.2/3.8 mmHg

    Average Reduction of sodiumin mg/day

    1700 mg/day

    2300 mg/day

    Normotensives

    Reduction of BP

    2.0 / 1.0 mmHg

    3.6/1.7 mmHg

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    2012 Canadian Hypertension EducationProgram (CHEP)

    Important messages from past recommendations

    High dietary sodium is estimated to increase blood pressure inthe Canadian population to the extent that 1,000,000 Canadiansmeet the diagnostic criteria for hypertension who wouldotherwise have normal blood pressure

    Most of the sodium in Canadian diets comes from processedfoods and restaurants.

    Pizza, breads, soups and sauces usually have high amounts ofsodium

    Patient information on how to achieve a reduced sodium diet

    can be found at www.hypertension.ca

    Aim to reduce dietary sodium intake to prevent and controlhypertension

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    Exercise should be prescribed as an adjunctive to pharmacological therapy

    Lifestyle Recommendations for Hypertension:Physical Activity

    Should be prescribed to reduce blood pressure

    Frequency - Four to seven days per weekF

    Intensity - ModerateI

    Time - 30-60 minutesT

    Type Cardiorespiratory Activity- Walking, jogging

    - Cycling- Non-competitive swimming

    T

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    Lifestyle Recommendations for Hypertension:Weight Loss

    Height, weight, and waist circumference (WC) should be measured

    and body mass index (BMI) calculated for all adults.

    Hypertensive and all patients

    BMIover 25- Encourage weight reduction

    - Healthy BMI: 18.5-24.9 kg/m2

    Waist CircumferenceMen

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    Courtesy J.P. Desprs 2006

    Measure here

    Iliac crest

    Waist Circumference Measurement

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    Lifestyle Recommendations for Hypertension:Alcohol

    Low risk alcohol consumption

    Women: maximum of 9 standard drinks/week

    Men: maximum of 14 standard drinks/week

    0-2 standard drinks/day

    A standard drink is about 142 ml or 5 oz of wine (12% alcohol). 341 mL or

    12 oz of beer (5% alcohol) 43 mL or 1.5 oz of spirits (40% alcohol).

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    Lifestyle Recommendations for Hypertension:Stress Management

    Hypertensive patientsin whom stress appears to be an important issue

    Individualized cognitive behavioural interventions aremore likely to be effective when relaxation techniques

    are employed.

    Stress management

    Behaviour Modification

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    Impact of Lifestyle Therapies on Blood Pressurein Hypertensive Adults

    Intervention Intervention SBP/DBP

    Reduce sodium intake-1800 mg/day sodium

    Hypertensive

    -5.1 / -2.7

    Weight loss per kg lost -1.1 / -0.9

    Alcohol intake -3.6 drinks/day -3.9 / -2.4

    Aerobic exercise 120-150 min/week -4.9 / -3.7

    Dietary patternsDASH diet

    Hypertensive -11.4 / -5.5

    Padwal R. et al. CMAJ SEPT. 27, 2005; 173 (7) 749-751

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    Lifestyle Therapies in Adults with Hypertension:Summary

    Intervention Target

    Reduce foods withadded sodium

    < 2300 mg /day

    Weight loss BMI

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    Epidemiologic impact on mortality of bloodpressure reduction in the population

    Reduction in SBP(mmHg)

    % Reduction in Mortality

    Stroke CHD Total

    2 -6 -4 -3

    3 -8 -5 -4

    5 -14 -9 -7

    Adapted from Whelton, P. K. et al. JAMA 2002;288:1882-1888

    AfterIntervention

    BeforeIntervention

    Reduction in BPPrevalence%

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    II. Indications for

    Pharmacotherapy

    2012 Canadian Hypertension

    Education ProgramRecommendations

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    II. Indications for Pharmacotherapy

    Usual blood pressure threshold values for initiation

    of pharmacological treatment of hypertension

    Condition Initiation

    SBP or DBP mmHg

    Systolic or Diastolic hypertension u140/90

    Diabetes

    ChronicK

    idney Disease

    u130/80

    u

    140/90

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    II. Indications for Pharmacotherapyafter diagnosis of hypertension (1)

    Patients at low risk with stage 1 hypertension(140-159/90-99 mmHg) lifestyle modification can be the sole therapy.

    Patients with target organ damage (e.g. left

    ventricular hypertrophy) (140-159/90-99 mmHg) Treat with pharmacotherapy

    Patients with diabetes or chronic kidney diseaseshould be considered for pharmacotherapy if the

    blood pressure is equal or over 140/90 mmHg

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    II. Indications for Pharmacotherapyafter diagnosis of hypertension (2)

    Patients with other risk factors (over 90% ofCanadians with hypertension have other risk factors)(140-159/90-99 mmHg despite lifestyle modification)

    Treat with pharmacotherapy

    Treatment Gap Alert: Many younger hypertensiveCanadians with multiple cardiovascular risks arecurrently not treated with pharmacotherapy. Healthcare professionals need to be aware of this importantcare gap and recommend pharmacotherapy.

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    III. Choice of pharmacological

    therapy

    2012 Canadian Hypertension

    Education ProgramRecommendations

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    III. Choice of Pharmacological TreatmentUncomplicated

    Associated risk factors?

    or

    Target organ damage/complications?

    or

    Concomitant diseases/conditions?

    IndividualizedTreatment

    (and compelling

    indications)

    YES

    Treatment in theabsence of compelling

    indications for specific

    therapies

    NO

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    III. Choice of Pharmacological Treatment

    1. Treatment of Systolic/Diastolic hypertensionwithout other compelling indications

    2. Treatment of Isolated Systolic hypertension without

    other compelling indications

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    III. Treatment of Adults with Systolic/DiastolicHypertension without Other Compelling Indications

    TARGET 20

    mmHg systolic or >10 mmHg diastolic above target

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    III. Considerations Regarding the Choice ofFirst-Line Therapy

    Use caution in initiating therapy with 2 drugs in whom adverseevents are more likely (e.g. frail elderly, those with posturalhypotension or who are dehydrated).

    ACE inhibitors, renin inhibitors and ARBs are contraindicated inpregnancy and caution is required in prescribing to women of childbearing potential.

    Beta blockers are not recommended as first line therapy for patientsage 60 and over without another compelling indication.

    Diuretic-induced hypokalemia should be avoided through the use ofpotassium sparing agents if required.

    The use of dual therapy with an ACE inhibitor and an ARB should

    only be considered in selected and closely monitored people withadvanced heart failure or proteinuric nephropathy.

    ACE-inhibitors are not recommended (as monotherapy)for black patients without another compelling indication.

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    III. Add-on Therapy for Systolic/DiastolicHypertension without Other Compelling Indications

    IF BLOOD PRESSUREIS NOT

    CONTROLLED CONSIDER

    Nonadherence Secondary HTN Interfering drugs or lifestyle White coat effect

    If blood pressure is still not controlled, or there are adverse effects,

    other classes of antihypertensive drugs may be combined (such as

    alpha blockers or centrally acting agents).

    2.Triple or Quadruple Therapy

    1. Add-on Therapy

    If partial response to monotherapy

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    Drug Combinations

    When combining drugs, use first-line therapies.

    Two drug combinations of beta blockers, ACEinhibitors and angiotensin receptor blockers have notbeen proven to have additive hypotensive effects.

    Therefore these potential two drug combinationsshould not be used unless there is a compelling (nonblood pressure lowering) indication

    Combinations of an ACEI with an ARB do not reducecardiovascular events more than the ACEI alone andhave more adverse effects therefore are notgenerally recommended

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    Drug Combinations contd

    Caution should be exercised in combining a nondihydropyridine CCB and a beta blocker to reducethe risk of bradycardia or heart block.

    Monitor serum creatinine and potassium whencombining K sparing diuretics (such as aldosteroneantagonists), ACE inhibitors and/or angiotensinreceptor blockers.

    If a diuretic is not used as first or second line therapy,

    triple dose therapy should include a diuretic, whennot contraindicated.

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    Medication Use and BP Controlin ALLHAT

    0

    20

    40

    60

    80

    100

    Baseline 6 mo 1 y 3 y 5 y

    %

    3 Drugs

    2 Drugs

    1 drug

    % controlled-

    Canadian sites

    Cushman et al. J Clin Hypertens2002;4:393-404

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    Ratio of Incremental SBP lowering effect atstandard dose Combine or Double?

    1.04 1

    1.16

    0.891.01

    0.19 0.23 0.2

    0.37

    0.22

    0

    0.2

    0.4

    0.6

    0.8

    1

    1.2

    1.4

    Thiazide -blocker ACE-I CCB All

    Combine Double

    Inc

    remenalSBPr

    eductionratio

    Ob

    served/Expected

    (additive)

    Wald et al, Combination Versus Monotherapy for Blood Pressure Reduction,The American Journal of Medicine, Vol 122, No 3, March 2009

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    BP lowering effects from antihypertensive drugs

    Dose response curves for efficacy are relatively flat

    80% of the BP lowering efficacy is achieved at half-standard dose

    Combinations of standard doses have additive bloodpressure lowering effects

    Law. BMJ 2003

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    III. Summary: Treatment of Systolic-DiastolicHypertension without Other Compelling Indications

    CONSIDER

    Nonadherence Secondary HTN Interfering drugs or

    lifestyle White coat effect

    Dual Combination

    Triple or Quadruple

    Therapy

    Lifestyle modification

    Thiazidediuretic

    ACEILong-acting

    CCBBeta-

    blocker*

    TARGET 20 mmHg systolicor>10 mmHg diastolic above target

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    III. Treatment Algorithm for Isolated SystolicHypertension without Other Compelling Indications

    INITIAL TREATMENT AND MONOTHERAPY

    Thiazide

    diuretic

    Long-acting

    DHPCCB

    Lifestyle modification

    therapy

    ARB

    TARGET

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    III. Add-on therapy for Isolated SystolicHypertension without Other Compelling Indications

    CONSIDER

    Nonadherence Secondary HTN Interfering drugs or

    lifestyle White coat effect

    If blood pressure is still not controlled, or there are adverse

    effects, other classes of antihypertensive drugs may be

    combined (such as ACE inhibitors, alpha adrenergic

    blockers, centrally acting agents, or nondihydropyridine

    calcium channel blocker).

    If partial response to monotherapy

    Long-acting

    DHPCCB

    Triple therapy

    Thiazide

    diureticARB

    Dual combinationCombine first line agents

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    III. Summary: Treatment of Isolated SystolicHypertension without Other Compelling Indications

    CONSIDER

    Nonadherence

    Secondary HTN Interfering drugs or

    lifestyle White coat effect

    Thiazidediuretic

    Long-actingDHPCCB

    Dual therapy

    Triple therapy

    Lifestyle modification

    therapy

    ARB

    TARGET

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    Choice of Pharmacological Treatmentfor Hypertension

    Individualized treatment

    Compelling indications: Ischemic Heart Disease

    Recent ST Segment Elevation-MI or non-ST Segment Elevation-MI

    Left Ventricular Systolic Dysfunction

    Cerebrovascular Disease

    Left Ventricular Hypertrophy Non Diabetic Chronic Kidney Disease

    Renovascular Disease

    Smoking

    Diabetes Mellitus With Nephropathy

    Without Nephropathy

    Global Vascular Protection for Hypertensive Patients Statins if 3 or more additional cardiovascular risks

    Aspirin once blood pressure is controlled

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    IV. Global Vascular Protection

    for Patients with Hypertension

    2012 Canadian Hypertension

    Education ProgramRecommendations

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    IV. Vascular Protection for HypertensivePatients: Statins

    In addition to currentCanadian recommendations on management

    of dyslipidemia, statins are recommended in high-risk

    hypertensive patients with established atherosclerotic disease

    or with at least 3 of the following criteria:

    Male

    Age 55 or older

    Smoking

    Total-C/HDL-C ratio of 6

    mmol/L or higher

    Family History of PrematureCV disease

    LVH

    ECG abnormalities

    Microalbuminuria or Proteinuria

    ASCOT-LLA Lancet 2003;361:1149-58

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    IV. Vascular Protection for HypertensivePatients: ASA

    Consider low dose ASA

    Caution should be exercised if BP is not controlled.

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    V. Goals of Therapy

    2012 Canadian Hypertension

    Education ProgramRecommendations

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    49

    Blood pressure target values for treatment of hypertensionCondition Target

    SBP and DBP mmHg

    Isolated systolic hypertension

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    V. Goals of Therapy

    To optimally reduce cardiovascular risk reduce theblood pressure to specified targets.

    This usually requires two or more drugs and lifestylechanges

    The systolic target is more difficult to achieve howevercontrolling systolic blood pressure is as important if not moreimportant than controlling diastolic blood pressure

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    Follow-up of blood pressureabove targets

    Patients with blood pressure above target arerecommended to be followed at least every 2ndmonth

    Follow-up visits are used to increase the intensity oflifestyle and drug therapy, monitor the response totherapy and assess adherence

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    VI. Treatment of Hypertension in Patients withIschemic Heart Disease

    Caution should be exercised when combining a non DHP-CCB and a beta-blocker If abnormal systolic left ventricular function: avoid non DHP-CCB (Verapamil or

    Diltiazem) Dual therapy with an ACEI and an ARB are not recommended in the absence of

    refractory heart failure The combination of an ACEi and CCB is preferred

    1. Beta-blocker2. Long-acting CCB

    Stable angina

    ACEI are recommended for most

    patients with established CAD*ARBs are not inferior to ACEI in IHD

    Short-actingnifedipine

    *Those at low risk with well controlled risk factors may not benefit from ACEI therapy

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    VI. Treatment of Hypertension in Patients with Recent STSegment Elevation-MI or non-ST Segment Elevation-MI

    Long-acting

    DihydropyridineCCB*

    Beta-blocker

    and ACEI or

    ARB

    Recent

    myocardialinfarction

    HeartFailure

    ?

    NO

    YES

    Long-actingCCB

    If beta-blockercontraindicated

    or not effective

    *Avoid non dihydropyridine CCBs (diltiazem, verapamil)

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    VII. Treatment of Hypertension with LeftVentricular Systolic Dysfunction

    Beta-blockers used in clinical trials were bisoprolol, carvedilol and metoprolol.

    If additional therapy is needed: Diuretic (Thiazide for hypertension; Loop for volume control)

    forCHF classII-IV

    or post MIand selected patients with L

    V

    dysfunction (see notes): Aldosterone Antagonist

    Systoliccardiac

    dysfunction

    ACEI and Beta blocker if ACEI intolerant: ARBTitrate doses of ACEI or ARB to those used in clinical trials

    If ACEI and ARB are contraindicated: Hydralazine and Isosorbidedinitrate in combination

    If additional antihypertensive therapy is needed:

    ACEI / ARB Combination Long-acting DHP-CCB (Amlodipine)NondihydropyridineCCB

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    VIII. Treatment of Hypertension in Association With StrokeAcute Stroke: Onset to 72 Hours

    Treat extreme BP elevation (systolic

    > 220 mmHg, diastolic > 120 mmHg)

    by 15-25% over the first 24 hour

    with gradual reduction after.

    If eligible for thrombolytic therapytreat very high BP (>185/110 mmHg)

    Acute

    ischemic

    Stroke

    Avoid excessive lowering of BP which can exacerbate ischemia

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    VIII. Treatment of Hypertension in Association With StrokeAfter the acute Phase of Stroke or TIA

    Strongly consider blood pressure reduction in all patients

    after the acute phase of stroke orTIA .

    Target BP < 140/90 mmHg

    An ACEI / diuretic

    combination is preferred

    StrokeTIA

    Combinations of an ACEI with an ARB are not recommended

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    IX. Treatment of Hypertension in Patients withLeft Ventricular Hypertrophy

    Hypertensive patients with left ventricular hypertrophy should

    be treated with antihypertensive therapy to lower the rate of

    subsequent cardiovascular events

    Vasodilators:

    Hydralazine, Minoxidil can increase LVH

    Left ventricular

    hypertrophy

    - ACEI- ARB,- CCB- Thiazide Diuretic- BB (if age below 60)*

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    X. Treatment of Hypertension in Patients withNon Diabetic Chronic Kidney Disease

    Chronic kidney

    disease and

    proteinuria *

    ACEI/ARB:Bilateral renalartery stenosis

    ACEI or ARB (if ACEI tolerated)

    Combination with other agents

    Additive therapy: Thiazide diuretic.

    Alternate: If volume overload: loop diuretic

    Target BP: < 140/90 mmHg

    * albumin:creatinine ratio [ACR] > 30 mg/mmol

    orurinary protein > 500 mg/24hr

    Monitor serum potassium and creatinine carefully in patients with CKD prescribed an ACEI or ARB

    Combinations of a ACEI and a ARB are specifically not recommended in the absence of proteinuria

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    XI. Treatment of Hypertension in Patients withRenovascular Disease

    Close follow-up and intervention (angioplasty and stenting or surgery) shouldbe considered for patients with: uncontrolled hypertension despite therapy

    with three or more drugs, or deteriorating renal function, or bilateralatherosclerotic renal artery lesions (or tight atherosclerotic stenosis in a

    single kidney), or recurrent episodes of flash pulmonary edema.

    Does not imply specific

    treatment choice

    Renovascular

    disease

    Caution in the use of ACEI or ARB inbilateral renal artery stenosis orunilateral disease with solitary kidney

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    XII. Treatment ofHypertension in association

    with Diabetes Mellitus2012 Canadian Hypertension

    Education ProgramRecommendations

    XII T f H i i i i

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    XII. Treatment of Hypertension in associationwith Diabetes Mellitus

    Threshold equal or over 130/80 mmHg and Target below 130/80 mmHg

    with

    Nephropathy*

    *Urinary albumin to creatinine

    ratio > 2.0 mg/mmol in men or

    > 2.8mg/mmol in women*

    Diabetes

    without

    Nephropathy**

    Isolated

    Systolic

    Hypertension

    Systolic-

    diastolic

    Hypertension

    * based on at least 2 of 3 measurements

    A combination of 2 first line drugs maybe considered as initial therapy if theblood pressure is >20 mmHg systolicor>10 mmHg diastolic above target

    Combinations of an ACEI with an ARB are specifically

    not recommended in the absence of proteinuria

    XII T t t f H t i i i ti

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    XII. Treatment of Hypertension in associationwith Diabetic Nephropathy

    IfCreatinine over 150 mol/L or creatinine clearance below 30 ml/min ( 0.5

    ml/sec), a loop diuretic should be substituted for a thiazide diuretic if control

    of volume is desired

    THRESHOLD equal or over 130/80 mmHg and TARGET below 130/80 mmHg

    DIABETES

    with

    Nephropathy

    ACEInhibitor

    or ARB

    IF ACEI and ARB arecontraindicated or not

    tolerated,SUBSTITUTE

    Long-actingCCB or

    Thiazide diuretic

    Addition of one or more ofLong-acting CCB or Thiazidediuretic

    3 - 4 drugs combination maybe needed

    Monitor serum potassium and creatinine carefully in patients with CKD prescribed an ACEI or ARB

    2012 C di H t i Ed ti

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    2012 Canadian Hypertension EducationProgram (CHEP)

    Important messages from past recommendations

    Patients with diabetes are at high cardiovascular risk

    Most patients with diabetes have hypertension

    Treatment of hypertension in patients with diabetes reducestotal mortality, myocardial infarction, stroke, retinopathy andprogressive renal failure rates.

    Treating hypertension in patients with diabetes reduces deathand disability and reduces health care system costs

    In diabetes, TARGET

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    XII. Treatment of Systolic-DiastolicHypertension without Diabetic Nephropathy

    1. ACEInhibitor or ARB or

    2. Dihydropyridine CCB or

    Thiazide diuretic

    IFACEInhibitor and ARB andDHP-CCB and Thiazide arecontraindicated or nottolerated,

    SUBSTITUTE

    Cardioselective BB* or

    Long-actingNON DHP-CCB

    More than 3 drugs may be needed to reach target values for diabetic patients

    * Cardioselective BB: Acebutolol, Atenolol, Bisoprolol , Metoprolol

    Threshold equal or over 130/80 mmHg and TARGET below 130/80 mmHg

    Combination of first line

    agents

    Addition of one or more of:Cardioselective BB orLong-acting CCB

    Diabetes

    without

    Nephropathy

    DHP: dihydropyridine

    Combinations of an ACEInhibitor with an ARB are specifically not recommended in theabsence of proteinuria

    ACCORD St d R lt d ti l f l k

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    ACCORD Study: Results and rationale for lackof impact on BP recommendations

    Overall BP study was neutral with no benefit of systolic target< 120 mmHg vs < 140 mmHg for primary outcome, yet:

    Power issue: Annual rate of primary outcome 1.87% in theintensive arm versus 2.09% in the standard arm vs 4%/yearevent rate projected during sample size calculations

    Significant interaction between BP and glycaemia controlstudies such that those in usual care glycaemia group (A1c7%+) had a significant improvement in primary outcome withlower BP target

    Secondary outcome for stroke reduction showed a benefit forlower BP target (41% RRR)

    Therefore no clear evidence supporting a change in BP targetsfor people with diabetes at this point

    ACCORD study NEJM 2010

    XII T t t f H t i i i ti

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    XII. Treatment of Hypertension in associationwith Diabetes Mellitus: Summary

    More than 3 drugs may be needed to reach target values for diabetic patients

    If Creatinine over 150 mol/L or creatinine clearance below 30 ml/min ( 0.5 ml/sec), a loop diuretic should be substituted for athiazide diuretic if control of volume is desired

    Threshold equal or over 130/80 mmHg and TARGET below 130/80 mmHg

    Diabetes

    with

    Nephropathy

    > 2-drugcombinations

    ACEInhibitor

    or ARB

    without

    Nephropathy

    1. ACEInhibitoror ARB

    or

    2. DHP-CCB orThiazidediuretic

    Monitor serum potassium and creatinine carefully in patients with CKD prescribed an ACEI or ARB

    Combinations of an ACEI with an ARB are specifically not recommended in the absence of proteinuria

    A combination of 2 first linedrugs may be considered asinitial therapy if the bloodpressure is >20 mmHg systolicor >10 mmHg diastolic abovetarget. Combining an ACEi and

    a DHP-CCB is recommended.

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    XIII. Adherence

    2012 Canadian HypertensionEducation Program

    Recommendations

    XIII Adh t ti h t i t

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    XIII. Adherence to anti-hypertensive managementcan be improved by a multi-pronged approach

    Assess adherence to pharmacological and non-pharmacological therapy at every visit

    Teach patients to take their pills on a regular scheduleassociated with a routine daily activity e.g. brushingteeth.

    Simplify medication regimens using long-acting once-daily dosing

    Utilize fixed-dose combination pills

    Utilize unit-of-use packaging e.g. blister packaging Replacing multiple pill antihypertensive combinations

    with single pill combinations!

    XIII Adherence to anti hypertensive management

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    XIII. Adherence to anti-hypertensive managementcan be improved by a multi-pronged approach

    Encourage greater patient responsibility/autonomy inregular monitoring of their blood pressure

    Educate patients and patients' families about theirdisease/treatment regimens verbally and in writing

    Use an interdisciplinary care approach coordinatingwith work-site health care givers and pharmacists ifavailable

    New Patient Resources for

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    New Patient Resources forHypertension Online

    www.hypertension.ca/tools - Download current resources for the prevention andcontrol of hypertension

    www.myBPsite.ca - Have your patients sign up to access the latest hypertensionresources

    www.lowersodium.ca - Tools and resources for healthcare professionals to use ineducating other healthcare professionals, the public or patients about the risks of high

    dietary sodium in Canada. www.sodium101.ca -To access a simple to use demonstration of food sodium content

    for your patients

    www.c-changeprogram.ca -To learn more about the harmonized recommendationsfor CVD prevention and treatment

    www.heartandstroke.ca/BP -To monitor home blood pressure and encourage selfmanagement of lifestyle

    www.canadianstrokenetwork.ca Download current resources to support bestpractice recommendations for stroke care

    http://www.hypertension.qc.ca/ - Socit Qubcoise dhypertension artrielle

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    Public translation of CHEP recommendations

    Hypertension recommendations for the public

    Translated into 4 Indo-Asian languages (2007)

    Based on CHEP guidelines (annually updated)

    Download at www.hypertension.ca

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    Sodium Slide Kit

    Tool used to educate the public and patients ondietary sodium.

    Annually updated.

    Download at www.hypertension.ca

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    Brief Hypertension Action Tool

    Can by used by a healthcare provider to better inform and engage a

    hypertensive patient to ultimately become more active in their

    care.

    Involves 3 Action Tools:

    Action Tool # 1 Explains High BP

    Action Tool # 2 Self-management of

    lifestyle

    Action Tool # 3 Proper home measurement& information about medication

    Download at www.hypertension.ca

    Measuring Blood Pressure the Right Way

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    Measuring Blood Pressure the Right Way Poster

    Pocket cards can beordered from ourwebsite.

    Brief highlights:1. Preparing to taking your

    blood pressure

    2. Using endorsed BPdevices.

    Download at www.hypertension.ca

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    Summary I

    Regarding the treatment of hypertension, therecommendations endorse:

    Know the current blood pressure of all your patients

    Most Canadians will develop hypertension during their lives.

    Routine assessment of blood pressure is required for earlydetection and risk management

    Encourage the use of approved devices and propertechnique to measure blood pressure at home.

    Most can assess blood pressure at home. Home measurement

    can confirm a diagnosis of hypertension, improve adherence totherapy and control rates and detect patients with white coat ormasked hypertension.

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    Summary II

    Regarding the treatment of hypertension, therecommendations endorse:

    Assess and manage CV risk in hypertensives

    high dietary sodium intake, smoking, dyslipidemia,dysglycemia, abdominal obesity, unhealthy eating, and physical

    inactivity.

    LIFESTYLE MODIFICATION

    Sustained lifestyle modification is the cornerstone for theprevention and control of hypertension and the management ofcardiovascular disease. Encourage patients to reduce theirsodium intake according to Health Canadas recommendations.

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    Summary III

    Regarding the treatment of hypertension, therecommendations endorse:

    TREATING TO TARGET BP Treat blood pressure to less than

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    For your patients ask themto sign up atwww.myBPsite.ca for freeaccess to the latestinformation & resources on

    high blood pressure

    For health care professionals sign up atwww.hypertension.ca forautomatic updates and oncurrent hypertension

    educational resources