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The 5th ARADOS Annual Meeting TRIP international comparison among 11 thyroid radioiodine monitoring institutions in China Jianfeng ZHANG E-mail[email protected]Tel+86-133-9163-8287 November 6, 2019

TRIP international comparison among 11 thyroid radioiodine ... · TRIP is coordinated by the Radiation Protection Functional Area and Assurance Management Office of the Environment,

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Page 1: TRIP international comparison among 11 thyroid radioiodine ... · TRIP is coordinated by the Radiation Protection Functional Area and Assurance Management Office of the Environment,

The 5th ARADOS Annual Meeting

TRIP international comparison among 11 thyroid

radioiodine monitoring institutions in China

Jianfeng ZHANG

E-mail:[email protected]; Tel:+86-133-9163-8287

November 6, 2019

Page 2: TRIP international comparison among 11 thyroid radioiodine ... · TRIP is coordinated by the Radiation Protection Functional Area and Assurance Management Office of the Environment,

2019/11/26

Content

Thyroid Radioiodine Intercomparison Program(TRIP)1

Direct measurement of nuclear medicine staff2

Future research planning3

Page 3: TRIP international comparison among 11 thyroid radioiodine ... · TRIP is coordinated by the Radiation Protection Functional Area and Assurance Management Office of the Environment,

The Thyroid Radioiodine Intercomparison Program (TRIP) provides

participating facilities with an independent means of evaluating in vivo

thyroid radioiodine measurements, using the International Atomic Energy

Agency (IAEA)/American National Standards Institute (ANSI) thyroid

calibration neck phantom (see International Commission on Radiation Units

& Measurements [ICRU] Report #48) and NIST- traceable isotopes for 125I

and 131I.

TRIP is coordinated by the Radiation Protection Functional Area and

Assurance Management Office of the Environment, Safety and Health

Directorate at Lawrence Livermore National Laboratory (LLNL) in

Livermore, CA.

LLNL established TRIP in response to requirements by ANSI N13.30,

ISO/IEC 17025 (Section 5.6.2.1.1), Department of Energy Laboratory

Accreditation Program (DOELAP), and other regulatory agencies for

participation in a suitable program of interlaboratory comparison. TRIP

intercomparison results can be used to assist participating facilities in

demonstrating compliance with federal and state regulations.

TRIP was unanimously approved by the Conference Radiation Control

Program Directors, Inc. (CRCPD) as an acceptable accreditation program.

Page 4: TRIP international comparison among 11 thyroid radioiodine ... · TRIP is coordinated by the Radiation Protection Functional Area and Assurance Management Office of the Environment,

TRIP(Thyroid Radioiodine Intercomparison Program)

Page 5: TRIP international comparison among 11 thyroid radioiodine ... · TRIP is coordinated by the Radiation Protection Functional Area and Assurance Management Office of the Environment,

TRIP(Thyroid Radioiodine Intercomparison Program)

Page 6: TRIP international comparison among 11 thyroid radioiodine ... · TRIP is coordinated by the Radiation Protection Functional Area and Assurance Management Office of the Environment,

PHANTOM

Page 7: TRIP international comparison among 11 thyroid radioiodine ... · TRIP is coordinated by the Radiation Protection Functional Area and Assurance Management Office of the Environment,

Sample

1018

Page 8: TRIP international comparison among 11 thyroid radioiodine ... · TRIP is coordinated by the Radiation Protection Functional Area and Assurance Management Office of the Environment,

11 thyroid radioiodine monitoring institutions in China

1. National Institute for Radiological Protection, Chinese Center

for Disease Control and Prevention

2. Institute of Radiation Medicine, Chinese Academy of Medical

Sciences

3. Zhejiang Provincial Center for Disease Control and

Prevention

4. The Inner Mongolia Autonomous Region Comprehensive

Center for Disease Control and Prevention

5. Shenzhen Prevention and Treatment Center for

Occupational Diseases

6. Gansu Provincial Center for Disease Control and Prevention

7. Guangdong Province Hospital for Occupational Disease

Prevention and Treatment

8. Liaoning Provincial Center for Disease Control and

Prevention

9. Fujian Center for Prevention and Control of Occupational

Diseases and Chemical Poisoning

10. China Institute of Atomic Energy

11. Beijing Center for Disease Prevention and Control

A. National Institutes: 3

B. Provincial Institutes: 7

C. Municipal Institute: 1

Page 9: TRIP international comparison among 11 thyroid radioiodine ... · TRIP is coordinated by the Radiation Protection Functional Area and Assurance Management Office of the Environment,

Measuring Equipment

Manufactor Type Quantity

Canberra INSPECTOR

1000

7

ORTEC AMTEC-100 2

BNC 940, 945 2

TARGET FieldSPEC 2

CIAE 2

Page 10: TRIP international comparison among 11 thyroid radioiodine ... · TRIP is coordinated by the Radiation Protection Functional Area and Assurance Management Office of the Environment,

Canberra: InSpector 1000

Page 11: TRIP international comparison among 11 thyroid radioiodine ... · TRIP is coordinated by the Radiation Protection Functional Area and Assurance Management Office of the Environment,

ORTECl: AMETEK-100

Page 12: TRIP international comparison among 11 thyroid radioiodine ... · TRIP is coordinated by the Radiation Protection Functional Area and Assurance Management Office of the Environment,

Berkeley Nucleonics Corporation (BNC)

940 SAM III Handheld

Isotope Identifier

945 SAM III Isotope Identifier

Page 13: TRIP international comparison among 11 thyroid radioiodine ... · TRIP is coordinated by the Radiation Protection Functional Area and Assurance Management Office of the Environment,

CIAE

Page 14: TRIP international comparison among 11 thyroid radioiodine ... · TRIP is coordinated by the Radiation Protection Functional Area and Assurance Management Office of the Environment,

Data analysis template

Page 15: TRIP international comparison among 11 thyroid radioiodine ... · TRIP is coordinated by the Radiation Protection Functional Area and Assurance Management Office of the Environment,

Data analysis template

Page 16: TRIP international comparison among 11 thyroid radioiodine ... · TRIP is coordinated by the Radiation Protection Functional Area and Assurance Management Office of the Environment,

TRIP Result (I-131)

Facility code

Facility average result in

Bq

Facility average

uncertainty

in Bq

ANSI 13.30 1996

calculated bias

ANSI N13.30 2011

RMSE*

Meets ANSI 13.30

1996 acceptance

criteria

–25% to +50%

Meets ANSI

13.30 2011

acceptance

criteria RMSE

<0.25*

5 2.19E+04 2.96E+02 -0.02 0.02 yes yes

10-HPGe 2.25E+04 1.62E+03 0.01 0.01 yes yes

10-LaBr3 2.25E+04 3.35E+03 0.01 0.02 yes yes

10-NaI 2.47E+04 1.84E+03 0.11 0.11 yes yes

15 2.18E+04 4.54E+02 -0.02 0.03 yes yes

25 2.34E+04 8.56E+02 0.05 0.05 yes yes

30 NR NR NR NR NR NR

35 2.17E+04 9.69E+02 -0.03 0.03 yes yes

39 2.15E+04 4.16E+03 -0.04 0.04 yes yes

40 2.23E+04 3.38E+03 0.00 0.04 yes yes

45 1.76E+04 2.39E+02 -0.21 0.21 yes yes

50 2.05E+04 1.86E+03 -0.08 0.09 yes yes

65 2.23E+04 7.47E+02 0.00 0.04 yes yes

75-A-1 2.19E+04 2.60E+03 -0.02 0.04 yes yes

75-A-2 2.21E+04 2.40E+03 -0.01 0.01 yes yes

75-B 2.16E+04 2.34E+03 -0.03 0.03 yes yes

75-C 2.06E+04 3.10E+03 -0.08 0.08 yes yes

75-D 1.91E+04 3.96E+03 -0.14 0.15 yes yes

75-E 2.13E+04 3.70E+03 -0.04 0.08 yes yes

75-F 1.98E+04 2.53E+03 -0.11 0.13 yes yes

75-G-1 2.51E+04 5.26E+03 0.13 0.16 yes yes

75-G-2 2.30E+04 2.70E+03 0.03 0.03 yes yes

75-G-3 2.32E+04 2.33E+03 0.04 0.05 yes yes

75-H 2.10E+04 4.43E+03 -0.06 0.06 yes yes

75-I-1 2.14E+04 2.69E+03 -0.04 0.04 yes yes

75-I-2 2.37E+04 2.78E+03 0.06 0.10 yes yes

75-J 1.98E+04 1.42E+03 -0.11 0.12 yes yes

75-K 2.97E+04 3.48E+03 0.33 0.34 yes no

95 2.10E+04 1.36E+03 -0.06 0.06 yes yes

97 2.40E+04 1.19E+03 0.07 0.08 yes yes

99 2.43E+04 2.36E+02 0.09 0.09 yes yes

Page 17: TRIP international comparison among 11 thyroid radioiodine ... · TRIP is coordinated by the Radiation Protection Functional Area and Assurance Management Office of the Environment,

TRIP Result (I-125)

Facility code

Facility

average

result in Bq

Facility average

uncertainty

in Bq

ANSI 13.30 1996

calculated bias

ANSI

N13.30 2011

RMSE*

Meets ANSI 13.30

1996 acceptance

criteria

–25% to +50%

Meets ANSI 13.30

2011 acceptance

criteria RMSE

<0.25*

5 9.83E+03 7.40E+01 0.03 0.03 yes yes

10 1.06E+04 2.40E+03 0.11 0.14 yes yes

15 8.61E+03 8.56E+01 -0.10 0.10 yes yes

25 9.59E+03 1.63E+02 0.00 0.00 yes yes

30 N.R. N.R. N.R. N.R. NR NR

35 8.92E+03 9.08E+02 -0.07 0.07 yes yes

39 9.29E+03 1.91E+03 -0.03 0.08 yes yes

40 9.78E+03 1.59E+03 0.02 0.04 yes yes

45 8.70E+03 1.00E+02 -0.09 0.09 yes yes

50 7.93E+03 4.32E+02 -0.17 0.17 yes yes

55 1.19E+04 2.48E+02 0.24 0.25 yes no

65 9.30E+03 4.82E+02 -0.03 0.03 yes yes

75-A-1 1.25E+04 1.57E+03 0.31 0.31 yes no

75-D 1.23E+04 2.58E+03 0.28 0.30 yes no

75-E 1.14E+04 1.77E+03 0.19 0.19 yes yes

75-F 7.61E+03 1.45E+03 -0.21 0.22 yes yes

75-G-1 1.08E+04 1.64E+03 0.13 0.14 yes yes

75-G-2 1.13E+04 1.46E+03 0.18 0.19 yes yes

75-G-3 9.67E+03 1.21E+03 0.01 0.01 yes yes

75-H 1.12E+04 1.37E+03 0.16 0.17 yes yes

75-I-2 9.95E+03 1.28E+03 0.04 0.04 yes yes

75-J 1.03E+04 1.26E+03 0.07 0.07 yes yes

75-K 1.08E+04 1.39E+03 0.13 0.13 yes yes

95 8.77E+03 9.16E+02 -0.08 0.09 yes yes

97 9.88E+03 4.08E+02 0.03 0.04 yes yes

99 9.16E+03 8.48E+02 -0.04 0.06 yes yes

Page 18: TRIP international comparison among 11 thyroid radioiodine ... · TRIP is coordinated by the Radiation Protection Functional Area and Assurance Management Office of the Environment,

Radioiodine monitoring of nuclear medicine staff

Page 19: TRIP international comparison among 11 thyroid radioiodine ... · TRIP is coordinated by the Radiation Protection Functional Area and Assurance Management Office of the Environment,

Future research planning

1. Air monitoring of radioiodine measurement

2. Measurement of other nuclides in nuclear

medicine

3. Monitoring methods of nuclear medicine

Page 20: TRIP international comparison among 11 thyroid radioiodine ... · TRIP is coordinated by the Radiation Protection Functional Area and Assurance Management Office of the Environment,

Air monitoring in nuclear medicine

Page 21: TRIP international comparison among 11 thyroid radioiodine ... · TRIP is coordinated by the Radiation Protection Functional Area and Assurance Management Office of the Environment,

Measurement of other nuclides in nuclear medicine

Page 22: TRIP international comparison among 11 thyroid radioiodine ... · TRIP is coordinated by the Radiation Protection Functional Area and Assurance Management Office of the Environment,

Monitoring methods of nuclear medicine

EURADOS: ICIDOSE 2017

Page 23: TRIP international comparison among 11 thyroid radioiodine ... · TRIP is coordinated by the Radiation Protection Functional Area and Assurance Management Office of the Environment,

Thank You For Your Attention!

E-mail:[email protected]; Tel:+86-133-9163-8287