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: ,
:.
2014
2
ALCOHOLISM:
A THERAPEUTIC APPROACH
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................................................................................................................... 8
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.................................................................................................................... 10
................................................................................................................... 12
1: ......................................................................... 13
1.1. .................................................................................................................. 13
1.2. ........................................................................................................ 16
1.3. ............................................................. 18
1.4. ........................................................ 19
2: ................. 21
2.1. .................................................................................. 21
2.2. ................................................................... 22
2.3. .......................................................................................... 24
2.4. ..................................................... 28
2.4.1. .................................................................................................. 29
2.4.2. .................................................................................................. 32
2.4.3. . ................................................................................................... 33
2.5. .......................................... 35
3: 38
3.1. ............................................................................................ 38
3.1.1. ............................................................................................................................. 38
3.1.2 .......................................... 40
3.1.3 ............................................................. 41
3.1.4 ................................. 43
3.1.5. ........................................................................... 44
3.2. ......................................................................................... 46
3.2.1. ............................................................ 46
3.2.2. ........................... 48
7
3.3. .............................................................................................. 49
3.3.1. ............................ 49
3.3.2. .................................... 50
3.3.3. ............... 52
3.4. .......................................... 52
3.4.1. ..................................................... 53
3.4.2. ................... 56
3.4.3. ............. 59
3.4.4. ...................................................... 61
3.5. ................................ 63
: ........................................................... 65
1. GDNF: ,
....................................................................................................................................... 66
2.
mTORC1 ....................... 67
3.
........................... 68
4.
20 .................................... 69
5. :
/
.......................................................................................................... 70
6.
.......................................................................... 72
........................................................................................................ 73
................................................................................................................. 75
........................................................................................................... 76
....................................................................... 80
.............................................................................................. 83
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: addiction, alcoholism, episodic heavy drinking, alcoholic medications
76
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-
12. , . (1988) , .
. 4(1): 55-68
13. , . & , (2003) .
. :
14. , . (2009) :
.... . 46(2):92-99.
15. , .. (2010)
. . 27(5): 767-775
16. , . (2005) .
:
17. , . (2001) . :
18. , . (2000 ) . :
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