Keystone Symposia on Molecular and Cellular Biology is a nonprofit organization headquartered in Colorado, USA directed and supported by the scientific community.

Keystone Symposia is pleased to present

Type 2 Immunity: Initiation, Maintenance, Homeostasis and Pathology joint with the meeting on Pathogenic Processes in Asthma and COPD

Scientific Organizers: Richard M. Locksley and Judith E. Allen

January 10–15, 2013 | Santa Fe Community Convention Center | Santa Fe, New Mexico | USA

Diseases associated with allergy and asthma are increasing in developed countries, with great consequences to healthcare costs. Often, these diseases reflect pathologic

outcomes of type 2 immunity and are characterized by infiltration of tissues with Th2 cells and eosinophils, by elevations in serum IgE and by alterations in epithelial and mucosal biology. These responses did not evolve to cause allergies, and clues to the evolutionary pressure to maintain this type of immune response may exist in the response to intestinal helminths, which cause chronic infestations in all vertebrate species on earth. This meeting will bring together scientists from diverse disciplines to discuss new findings in type 2 immunity that suggest close associations of these responses with tissue homeostasis, mucosal microbiomes and immune integrity that optimize overall fitness of the organism. The goals of this meeting are to:> Identify gaps in our understanding of type 2 immunity and

facilitate future research advances in the field; > Promote the development of novel therapeutic strategies

against diseases associated with type 2 immunity;> Encourage cross-disciplinary collaborations and establish

an ongoing dialogue for future research.

Session Topics: > Adaptations to Chronic Helminth Infection > Regulating the Type 2 Cytokines > Innate Helper Cells in Type 2 Immunity > Adaptive Th2 and TFH Cells > Commensals, Immunity and Epithelial Homeostasis > Myeloid Cells in Tissue Homeostasis > Initiating Type 2 Immunity > Pathologic Syndromes

Abstract & Scholarship Deadline: September 10, 2012Late-Breaking Abstract Deadline: October 10, 2012Early Registration Deadline: November 8, 2012Note: Scholarships are available to students and postdoctoral fellows and require a brief application and submission of an abstract. Short talk speakers will also be selected from abstracts. Early registration saves US$150 on later fee. Information shown is subject to possible change. Please visit meeting website for the most up-to-date program information.

www.keystonesymposia.org/13J1

Keystone Symposia on Molecular and Cellular Biology is a nonprofit organization headquartered in Colorado, USA directed and supported by the scientific community.

1.970.262.1230 | 1.800.253.0685 (US & Canada)

THURSDAY, JANUARY 10

Arrival and Registration

Welcome and Keynote Address (Joint) Bart N. Lambrecht, Ghent University, BelgiumThe Dendritic Cell Network and the Response to Allergens

FRIDAY, JANUARY 11

Adaptations to Chronic Helminth Infection (J1)Fred D. Finkelman, University of Cincinnati, USAOverview of Adaptations to Intestinal HelminthsMaria Yazdanbakhsh, Leiden University Medical Center, NetherlandsParasitic Helminths and the Human Immune ResponseAjay Chawla, University of California, San Francisco, USAMetabolic Consequences of Type 2 ImmunitySpeaker to be AnnouncedShort Talk(s) Chosen from Abstracts

New Insights into the Pathogenesis of Lung Diseases (J2)Sally E. Wenzel, University of Pittsburgh, USAEmerging Concepts on the Heterogeneity of AsthmaFernando D. Martinez, University of Arizona, USAEarly-Life Origins of Chronic Obstructive Pulmonary DiseaseAvrum Spira, Boston University, USAMolecular Insights into COPD via Transcriptomic ProfilingIan M. Adcock, Imperial College London, UKEpigenetic Regulation of Lung DiseasesShort Talk(s) Chosen from Abstracts

Regulating the Type 2 Cytokines (J1)Dirk E. Smith, Amgen Inc., USAThe Role of IL-33 in Regulating Innate Airway InflammationSteven F. Ziegler, Benaroya Research Institute and University ofWashington School of Medicine, USATSLP in the Regulation of Type 2 ImmunityRichard M. Maizels, University of Edinburgh, UKCoaptation of the Host Immune Response by Parasitic HelminthsShort Talk Chosen from Abstracts

Infectious Origins of Lung Disease (J2)James E. Gern, University of Wisconsin, USAVirus Infections and Asthma Inception and ExacerbationSebastian L. Johnston, Imperial College London, UKMechanisms of Rhinovirus-Induced Exacerbations in Asthma andCOPD

Michael J. Holtzman, Washington University, USAImmune Pathways Translating Viral Infection into Chronic AirwayDiseaseShort Talk Chosen from Abstracts

Poster Session 1

SATURDAY, JANUARY 12

Innate Helper Cells in Type 2 Immunity (Joint) Andrew N.J. McKenzie, Medical Research Council, UKNuocytes, IL-33 and Lung InflammationHergen Spits, University of Amsterdam, NetherlandsThe Spectrum of Human Innate Lymphoid CellsRichard M. Locksley, University of California, San Francisco, USAFunction-Marking Innate Helper Type 2 CellsShigeo Koyasu, Keio University School of Medicine, JapanType 2 Innate Immune Responses and the Natural Helper Cell

Adaptive Th2 and TFH Cells (J1)Speakers to be AnnouncedK. Mark Ansel, University of California San FranciscoMicroRNA Regulation of Tfh and Th2 Cell DevelopmentShane Crotty, La Jolla Institute for Allergy and Immunology, USATh2 - Tfh Cell DeterminantsShort Talk Chosen from Abstracts

Role of Th17 Cells in the Regulation of Lung Immunity (J2)Jay K. Kolls, University of Pittsburgh School of Medicine, USATh17 Cells as Critical Regulators of Host Immunity to Bacterial andFungal Infections at Mucosal SurfacesSusan V. Lynch, University of California, San Francisco, USAAirway Microbiota and Lung DiseaseMarsha Wills-Karp, Johns Hopkins Bloomberg School of PublicHealth, USAMicrobiota Regulation of Th17-Mediated Severe AsthmaShort Talk Chosen from Abstracts

Poster Session 2

SUNDAY, JANUARY 13

Commensals, Immunity and Epithelial Homeostasis (J1)Speaker to be AnnouncedWenjun Ouyang, Genentech, Inc., USAThe IL-10/22 Family of Cytokines in Epithelial HealthYasmine Belkaid, NIAID, National Institutes of Health, USAParasites and the Commensal Flora

* Session Chair  † Invited but not yet accepted     Program current as of August 12, 2012. Program subject to change. Meal formats are based on meeting venue.For the most up-to-date details, visit www.keystonesymposia.org/13J1 and www.keystonesymposia.org/13J2.

KEYSTONE SYMPOSIAon Molecular and Cellular Biology

Type 2 Immunity: Initiation, Maintenance, Homeostasis and Pathology (J1)Scientific Organizers: Richard M. Locksley and Judith E. Allen

Supported by an educational donation provided by Amgen

Pathogenic Processes in Asthma and COPD (J2)Scientific Organizers: Marsha Wills-Karp, Jay K. Kolls and Sebastian L. Johnston

January 10-15, 2013 •  Santa Fe Community Convention Center •  Santa Fe, New Mexico, USASupported by the Directors' Fund

Abstract & Scholarship Deadline: September 10, 2012 / Late-Breaking Abstract Deadline: October 10, 2012 / Early Registration Deadline: November 8, 2012

Sabine Eming, University of Cologne, GermanyTissue Repair and Type 2 ImmunityShort Talk(s) Chosen from Abstracts

Lung Development, Repair and Remodeling (J2)Jeffrey A. Whitsett, Cincinnati Children's Hospital Medical Center,USATranscriptional Networks Linking Mucus Metaplasia and InnateImmunity in the Respiratory EpitheliumPaul W. Noble, Duke University, USAMatrix Regulation of Lung Injury, Inflammation and RepairDarryl Knight, University of British Columbia, CanadaStem Cells for Repair of the AirwaysJoanne L. Wright, University of British Columbia, CanadaCigarette-Smoke-Induced COPDShort Talk(s) Chosen from Abstracts

Myeloid Cells in Tissue Homeostasis (J1)Judith E. Allen, University of Edinburgh, UKAAMsDavid Voehringer, University Hospital of Erlangen, GermanyEosinophils - What Have We Learned?Hajime Karasuyama, Tokyo Medical and Dental University, JapanBasophils - Innate Cells Regulated by the Adaptive ResponseShort Talk Chosen from Abstracts

Mechanisms of Chronic Obstructive Pulmonary Disease (J2)Shyam Biswal, Johns Hopkins School of Public Health, USAOxidative Stress Regulation of Lung Inflammation in COPDAugustine Choi, Harvard Medical School, USARegulation and Function of Autophagy in COPDFarrah Kheradmand, Baylor College of Medicine, USAAutoreactive T Cells in the Pathophysiology of Human and MouseEmphysemaShort Talk Chosen from Abstracts

Poster Session 3

MONDAY, JANUARY 14

Initiating Type 2 Immunity (Joint) Jean-Philippe Girard, CNRS, FranceIL-33 Processing and Activation by Inflammatory ProteasesJenny P. Ting, University of North Carolina at Chapel Hill, USAUric Acid and the InflammasomeMarco Idzko, University Hospital Freiburg, GermanyATP and P2X Receptors in Type 2 ImmunityJack A. Elias, Yale School of Medicine, USAChitin and Chitinases

Pathologic Syndromes (J1)Stuart G. Tangye, Garvan Institute of Medical Research, AustraliaLymphocyte Defects in Hyper IgE SyndromesThomas A. Wynn, NIAID, National Institutes of Health, USAPathogenesis of Type 2 ImmunityLawren C. Wu, Genentech, Inc., USAIgE Production and Memory in Health and DiseaseShort Talk Chosen from Abstracts

Therapeutic Opportunities in Asthma and COPD (J2)Ruth Tal-Singer, GlaxoSmithKline, USAChallenges and Opportunities in COPD Drug DevelopmentJohn G. Matthews, Genentech, Inc., USAAnti-IL-13 Therapy in AsthmaAlison L. Budelsky, Amgen Inc., USABlockade of IL-17RA in AsthmaShort Talk Chosen from Abstracts

TUESDAY, JANUARY 15

Departure

* Session Chair  † Invited but not yet accepted     Program current as of August 12, 2012. Program subject to change. Meal formats are based on meeting venue.For the most up-to-date details, visit www.keystonesymposia.org/13J1 and www.keystonesymposia.org/13J2.

KEYSTONE SYMPOSIAon Molecular and Cellular Biology

Type 2 Immunity: Initiation, Maintenance, Homeostasis and Pathology (J1)Scientific Organizers: Richard M. Locksley and Judith E. Allen

Supported by an educational donation provided by Amgen

Pathogenic Processes in Asthma and COPD (J2)Scientific Organizers: Marsha Wills-Karp, Jay K. Kolls and Sebastian L. Johnston

January 10-15, 2013 •  Santa Fe Community Convention Center •  Santa Fe, New Mexico, USASupported by the Directors' Fund

Abstract & Scholarship Deadline: September 10, 2012 / Late-Breaking Abstract Deadline: October 10, 2012 / Early Registration Deadline: November 8, 2012