University: Alexandria Faculty : Medicine Program ... · anemia. a2 – Identify recent advances in haematopoiesis and stem cell research. a3 – Identify recent advances in ... 3

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University: Alexandria

Faculty : Medicine

Program Specifications

(Academic year: 2015)


A. Basic Information:

1. Program title: : Doctor Degree in Hematology

2. Department offering the program; Internal medicine ( Clinical Hematology Unit)

3. Program Coordinator: Prof. Dr. Nahla A. Hamed.

4. External evaluator(s): Prof Dr Sameh Shamaa

5. Type of the program: Single

6. Date of most recent program specifications approval: October 2015 B. Professional Information:

1- Program Aims: This program is designed to provide candidates with the updated knowledge and skills that allow them to:

1.1. Deal successfully with common and difficult cases with diseases of blood and bone

marrow. 1.2. Interpret hematological manifestations of medical diseases and solid tumors.

1.3. Take decisions with emergency situation in hematology. 1.4. Apply evidence based medicine from updated reference.

1.5 Perform continuous self life-long learning

2- Acdemic reference standards (ARS)& ILOs:

Academic reference standards of Doctor Degree in Hematology designed and approved by Department of Internal Medicine (Hematology Unit) Faculty of Medicine. Alexandria

University. Based on:

Generic Academic Reference Standards (ARS): Postgraduate Medical Education, Egypt (2009). Published by National Authority for Quality Assurance and Accreditation of

Education (NAQAAE) National [http://naqaae.org/main/php/book/index.php]

Adapted from;

Specialty Training Curriculum for Hematology by Joint Royal Colleges of Physicians

Training Board (www.jrcptb.org.uk)

Domain Academic Reference

Standards (ARS)

ILOs

A. Knowledge and

understanding • – Identify Recent

advances in the field of

diagnosis and management of haematological diseases

including anaemia, coagulation disturbance and haematological

malignancies.

a1 – Identify recent advances in the causes, presentation,

complications, diagnosis and management of different types of

anemia. a2 – Identify recent advances in

haematopoiesis and stem cell

research. a3 – Identify recent advances in

diagnosis and management of inherited and acquired bone

marrow failure.


• –update his knowledge regarding the drugs used

in the field of haematology, as well as blood and blood products

a4 – Identify recent advances in diagnosis, classification and

management of acute and chronic leukemias in adults.

a5 – Identify recent advances in

the classification, natural history, molecular biology, and

therapeutic modalities of hematological malignancies.

a6 – Identify recent advances in

the histological classification of lymphomas approved by the

WHO. a7 – Identify recent advances in the

diagnostic methods used in the

assessment and the management congenital coagulation and

platelet disorders,

a8 – update his knowledge in the

pharmaceuticals and blood products available for the

management of excessive bleeding.

a9 – update his knowledge in the

field of blood transfusion.

a10 – update his knowledge in

classification of

myeloproliferative disorders, the required diagnostic methods and

the therapeutic options.

a11 – update his knowledge on the

impact of systemic disease on the

blood and bone marrow.

a12 – update his knowledge in haemostatic problems in

pregnancy and solid tumors

a13 – update his knowledge regarding indications and

management of bone marrow

transplantation

a14 – update his knowledge regarding chemotherapy regimens

used in the management of

hematological malignancies.


B. Intellectual

skills

▪ Analyze, deduce, extrapolate & evaluate

laboratory information to establish diagnosis and appropriate treatment planning.

▪ Take decisions in various professional situations of haematological problems according to the available data

▪ Apply evidence based medicine from updated reference.

b1 Analyze laboratory testing results

for the initial management of common and unusual

hematological disorders.

b2 Take decision in the diagnosis and appropriate treatment

planning. b3 Explain planned treatment

clearly to junior staff

b4 apply multidisciplinary team

work for managing complication

b5 Apply evidence based medicine

from updated printed and electronic reference.

C. Professional

skills • –Evaluate and improve

methods and tools used in patient management.

• –Plan professional courses to improve practice and enhance performance of juniors as regards

appropriate use of antibiotic regimens for treatment and prophylaxis in

immunosuppressed patient.

Management of complications of blood transfusion

appropriately monitoring of

anticoagulation

c1 - Plan professional courses of combination chemotherapy

regimens.

c2 – Plan professional courses for appropriate use of antibiotic

regimens for treatment and

prophylaxis in the immunosuppressed patient.

c3 – Plan professional courses for complications of blood transfusion appropriately

c4 – Plan professional courses

for use and monitoring of

anticoagulation

c5 – Evaluate and improve methods and tools used in stem

cell transplantation

c6 - Evaluate and improve methods and tools used in

diagnosis & management of

hematological emergencies.


D. General and

transferrable

skills

• Communicate with colleagues in other specialties effectively for proper diagnosis and treatment of the patients.

• -Direct his assistant team throughout the work

• Write and assess patient’s reports

• -Advance his knowledge and information continuously using

different printed and electronic sources.

d1- perform full explanation of the side effects of chemotherapy to

patients. d2-communicates effectively with

patients performing transplantation

and their family. d3-Communicate effectively with

colleagues in other specialties for proper management of the patients.

d4-Perform leadership

responsibilities d5- Write and appraise reports.

d6-perform continuous self lifelong learning

d7-Upgrade his scientific knowledge

utilizing all available sources.

E. Attitudes and

ethical

behavior

• Appreciate ethical,

religious and law

regulations during his

practice.

e1 Appreciates ethical communication of informed

consent.

e2 –-Evaluates the junior staff

ability to Communicate with

terminal patients and their relatives.

e3 –Demonstrates the importance of

supportive care for successive patient outcome.

e4 –Conducts and modifies multidisciplinary team working.

e5 Evaluates the ability of juniors

to conduct sympathetically bad news including terminal

progress.

Program courses ILOs Matrix

ILOs

Course title

A

1

A

2

A

3

A

4

A

5

A

6

A

7

A

8

A

9

A

1

0

A

1

1

A

1

2

A

1

3

A

1

4

Clinical and Chemical

pathology for hematology II

Hemopoiesis II x

Iron metabolism. And x x


anemia,

Acute leukemias II x x

Chronic leukemias II x x

x

Stem cell disorders II x

Lymphomas II x x

Myeloma II x x

Hemostasis II x x

Blood transfusion II x x

Hematological

manifestations of medical

diseases II

x x

Immunodeficiencies

Stem cell transplantation

Integrated hematology II

ILOs

Course title

B

1

B

2

B3 B4 B5 C

1

C

2

C

3

C4 C5 C6 D

1

D2 D

3

D

4

D5 D

6

D7 E1 E

2

E

3

E4 E5

Clinical and Chemical pathology for

hematology II

Hemopoiesis II x

Iron metabolism. And anemia, II

x x x x x

Acute leukemias II

x x x x x x x X X X X

Chronic leukemias II

x x x x x

Stem cell

disorders II

x x x

Lymphomas II x x x x x X

Myeloma II x x x x x X

Hemostasis II x x x x x

Blood

transfusion II

x x

Hematological

manifestations of medical diseases II

x x x

Immunodeficiencies

Stem cell transplantation

Integrated

hematology II


2- Curriculum Structure:

-Program duration: This program is fulfilled in not less than 2 years with a maximum of 5 years (4

semesters & thesis).

-Program structure: 1. Total hours: 52 Credit hours.

2. Obligatory subjects: 32 Credit Hours. 3. Thesis: 20 Credit Hours. 4. 2 Elective Subjects: 2 Credit Hours each = 4 hours.

-Program Content:

A. Obligatory Courses:

Code Course Credit hours

Contact hours Prerequisites

lectures practical other

1 050509151 Clinical and Chemical pathology for

hematology II

1 0.5 0.5

2 05151901 Haemopoiesis II 2 1 1

3 05151902 Iron Metabolism, Iron Deficiency and

Disorders of Haem Synthesis,

Megaloblastic Anaemia, Haemolytic Anaemias, Aplastic Anaemia

4 3 1

4 05151903 Acute Leukaemias II 2 1 1

5 051511904 Chronic Leukaemias II 2 1 1

6 05151905 Stem Cell Disorders II 3 2 1

7 05151906 Lymphomas II 2 1 1

8 05151907 Myeloma II 2 1 1

9 05151908 Haemostasis II 3 2 1

10 05151909 Blood Transfusion II 2 2 -

11 05151910 Haematological manifestation of

medical diseases II

2 1 1

12 05151911 Immunodeficiencies 1 0.5 0.5

13 05151912 Stem cell transplantation 2

14 05151913 Integrated hematology II 4

B. Elective Courses:

Code Subject Credit hours

05070739 Biostatistics and Computer 1

053109151 Imaging for hematology 1

05160832 Molecular Biology 1

- Others According to the Field of the Thesis 1

3- Program Admission Requirements: According to the regulations of the credit hour by laws of the Faculty of Medicine

Alexandria University (annex).

4- Regulations for Progression and Program Completion: According to the regulations of the credit hour by laws of the Faculty of Medicine

Alexandria University (annex).


5- Methods of student assessment:

Methods Intended Learning outcomes to be

assessed

1. Written Exam a1-a14, b1-b2, b5,c2-c3

2. Practical Exam B3-b4, c1,c4-c6

3. Assignments d1 – d7

4.Thesis d5-d7,e1-e5

6- Methods of program evaluation:

Evaluator Tool Sample

1. Students enrolled in the program Questionnaires.

2. Alumni --------

3. Stakeholders (Employers) Focus group

4. External Evaluator (s) Prof. Sameh Shamaa

5. Others:

Program Director: Prof Dr. Yahia Ganem Program Coordinator: Prof Dr. Nahla A Hamed


COURSE DESCRIPTION

1 Code Credit hours (1) Course Prerequisites

050509015 Lectures Clinical Clinical and Chemical

pathology for hematology

II

0.5 0.5


05151901 Lectures Clinical Haemopoiesis II

1 1

Introduction. Sites of haemopoiesis. The stromal microenvironment. Stem cell trafficking.

Organization of haemopoiesis. Haemopoietic growth factors and receptors. Clinical applications of

stem cell research. Selected bibliography. Seminars: update.


05151902 Lectures Clinical Iron Metabolism, Iron

Deficiency and Disorders

of Haem Synthesis,

Megaloblastic Anaemia, Haemolytic Anaemias,

Aplastic Anaemia

3 1

Distribution of body iron. Cellular iron homeostasis. Normal iron balance. Iron absorption. Internal

exchange. Haem synthesis. Diagnostic methods for investigating iron metabolism. Iron deficiency

anaemia. Causes of iron deficiency. Management of iron deficiency. Pathological alterations in haem synthesis. Selected bibliography.

Megaloblastic anaemia: Introduction. Underlying basic science. Clinical features. Haematological

findings. Cobalamin. Cobalamin analogues. Causes of cobalamin deficiency. Diagnosis of cobalamin deficiency. Tests for the cause of cobalamin deficiency. Folate. Causes of folate deficiency.

Diagnosis of folate deficiency. General management of megaloblastic anaemia. Prophylactic folic

acid. Megaloblastic anaemia not due to cobalamin or folate deficiency or altered metabolism. Other

nutritional anaemias. Inherited disorders of hemoglobin. Acquired haemolytic anaemias: Introduction. Immune haemolytic anaemias. Warm-type autoimmune

haemolytic anaemias. Cold-type autoimmune haemolytic anaemias. The non-immune acquired

haemolytic anaemias. Sickle cell disease. Disorders of red cell membrane. Inherited aplastic anaemia/bone marrow failure syndromes: Introduction. Fanconi anaemia.

Dyskeratosis congenital. Shwachman-Diamond syndrome. Diamond-Black fan anaemia. Congenital

and cyclical neutropenias. Thrombocytopenia with absent radii. Congenital amegakaryocytic thrombocytopenia. Conclusion. PNH.

Seminars: update.


05151903 Lectures Clinical Acute Leukaemias II

1 1


Acute myeloid leukemia. Epidemiology of disease. Pathophysiology. Disease classification.

Cytogenetics. Treatment. Future developments. Selected bibliography.

Adult acute lymphoblastic leukaemia: Introduction. Diagnosis. Clinical manifestations. Laboratory evaluation. Differential diagnosis. Initial evaluation and supportive therapy. Chemotherapy. Stem

Cell transplantation. Outcome of all subtypes and prognostic factors. Minimal residual disease-

practical application in adult ALL. Treatment with monoclonal antibodies. ABL tyrosine kinase inhibitors in Ph/BCR-ABL-positive ALL. Selected bibliography.

Seminars: update.


05151904 Lectures Clinical Chronic Leukaemias II

1 1

Introduction. Classification. Cytokinetics. Cytogenetics. Molecular biology. Clinical features.

Haematology. Management of chronic myeloid leukaemia in chronic phase. Treatment decisions for

newly diagnosed patients in chronic phase. Management of chronic myeloid leukaemia in advanced phase. Variants of chronic myeloid leukaemia. Selected bibliography.

Chronic lymphocytic leukaemia and other B-cell disorders: Introduction. Methodology for diagnosis.

Chronic lymphocytic leukaemia. Management. Prolymphocytic leukaemia. Hairy cell leukaemia. The leukaemic phase of low-grade NHL. Selected bibliography.

Seminars: update.


05151905 Lectures Clinical Stem cell disorders II

2 1

Myelodysplastic syndromes. Cytogenetics. Investigations. Classifcation. Pathogenesis. Prognosis.

Management.

Myeloproliferative disorders: The polycythaemia. Polycythaemia rubra vera. Essential thrombocythaemia. Idiopathic myelofibrosis.

Bone marrow transplantation.

Seminars: update.



05151906 Lectures Clinical Lymphomas

1 1

Non Hodgkin's lymphomas. Classifications. Epidemiology. Aetiology. Cytogenetics & oncogenes.

Clinical features. Investigations. Staging. Treatment. Specific types.

Hodgkin's lymphoma: Epidemiology. Classification. Pathogenesis. Presentation. Staging. Prognostic factors. Therapy.


05151907 Lectures Clinical Myeloma

1 1

Myeloma: Definition. Pathogenesis. Clinical features. Laboratory findings. Treatment. Monoclonal

gammopathy of uncertain significance. Waldenstrom macroglobulinaemia. Plasma cell leukemia.

Non-secretory myeloma. Hairy-chain diseases. Seminars: update.


05151908 Lectures Clinical Haemostasis II

2 1

Overview. Blood vessels. Platelets. Coagulation factors. Naturally occurring inhibitors. Fibrinolysis. Inherited bleeding disorders: Haemophilia A. Haemophilia B. Gene therapy. Von Willibrand disease.

Acquired coagulation, platelet & vascular bleeding: Disseminated intravascular coagulation.

Coagulopathy & massive blood loss. Vitamin K deficiency. Idiopathic thrombocytophric purpura. Non-thrombotic vascular purpuras. Inherited thrombophilia. Acquired venous thrombosis. TTP.

Congenital platelet disorders.

Seminars: update.


05150909 Lectures Clinical Blood Transfusion II

2 -

Blood component transfusion indications and complications.


05151910 Lectures Clinical Hematological

Manifestations of Medical

Diseases

1 1

Connective tissue disorders liver disease, renal disease, neurological disorders.


05151911 Lectures Clinical Immunodeficiencies


05151912 Lectures Clinical Stem cell transplantation


14 Code Credit hours (2) Course

05151913 Lectures Clinical Integrated hematology II 05151901-12

Course Specifications


Faculty: Medicine

Department:

Course InformationCourse Code:

05151906Course Name lymphoma II

Program in which the Course is Given: doctorate program in hematology

Number of Credit Hours2 Theoretical Clinical/Practical

Course Aimsto provide candidates with the updated knowledge and skills that allow themtodiagnose and manage successfully Lymphomas

Intended Learning Outcomes (ILOs)Program ILO (refer to programmatrix)

Course ILOs

A. KnowledgeandUnderstanding

a5 – Identify recent advances inthe classification, naturalhistory, molecular biology, andtherapeutic modalities ofhematological malignancies.

a6 – Identify recent advances in thehistological classification oflymphomas approved by theWHO.

a3 –update his knowledge in WHOclassification of lymphomaa4 Identify recent advances in the drugs used

in Lymphomas according to WHOclassification

B. Intellectualskills

b1 Analyze, deduce, extrapolate &evaluate laboratory testingresults for the initialmanagement of common andunusual hematologicaldisorders.

b2 Take decision in the diagnosisand appropriate treatmentplanning.

b5 Apply evidence based medicine

b1 Analyze & evaluate available laboratoryinformation to establish treatment planof Lymphomas.

b2 Analyze & deduce laboratory tests toestablish treatment of uncommon typesof Lymphomas.

b3 Take decisions in various professionalsituations in lymphoma

b5 Refer to evidence based medicine in

11

from updated printed andelectronic reference.

managing casesb6 Refer to updated reference in dealing with

difficult cases.

C.ProfessionalandPractical Skills

C1-Plan professional courses ofcombination chemotherapyregimens

C1-Evaluate and improve methods and toolsused in management of LymphomasC2–Plan professional courses to improve

practice and enhance performance ofjuniors as regards appropriate treatmentof Lymphomas

D. General Skills d1- perform full explanation of theside effects of chemotherapy topatients.

d1-Performleadership responsibilities inexplaining complications of chemotherapy topatientsd2- upgrade his scientific information utilizingall available printed and electronic sources tomanage side effects of chemotherapy

Course Content(Units/Topics)

Teaching/Learning MethodsLectures self

learningPractical/Clinical

Smallgroupdiscussion

Others

Non Hodgkin's lymphomas. Classifications. Epidemiology. Aetiology. Cytogenetics& oncogenes. Clinical features. Investigations. Staging. Treatment. Specific types.

Hodgkin's lymphoma: Epidemiology. Classification. Pathogenesis. Presentation. Staging. Prognostic factors. Therapy.

Please check () the appropriate method.

Student AssessmentMethods of Assessment Essay Objective questions

Case OSCE/OSPE

Assignment Logbook fulfillment

Others

Schedule of Assessment Mid-term %

End of term 100 %Distribution of Marks Written Exam 70 %

Practical/Clinical Exam 30 %Others %

List of Textbooks and ReferencesLecture Notes Print out of lectures

Course Text Books Postgraduate haematology

Suggested Extra Reading William haematology

Journals and Periodicals, others Bloodhaematologica

Course InstructorName: Prof. Nabil El-Halawani

Program CoordinatorName : Nahla Hamed Signature:

Program Director (Head of Department)Name: Prof . Signature: Yehia Ghanem



Faculty: Medicine

Department:Internal Medicine- Hematology Unit


05151912Course Name: stem cell transplantation

Program in which the Course is Given: MD in hematology

Number of Credit Hours2Theoretical Clinical/Practical

Course Aimsto provide candidates with the basic knowledge about the indications of HSCtransplantation, stem cell sources, pre transplant evaluation, and management during the transplantprocedure and post transplant complications.Intended Learning Outcomes (ILOs)

Program ILO (refer to programmatrix)

Course ILOs


-Understanding recent advances inthe classification , pathogenesis,molecular biology , diagnosis andtherapeutic modalities ofhematological diseases.

Identify recent advances in the field of HSCtransplantation regarding indications,selection of patients, pre-transplantevaluation, the transplant procedure andpost-transplant complications.


-Analysis and interpretation ofclinical data and laboratory resultsof various hematologicaldisorders.-Decision making in the diagnosisand appropriate treatment planningof hematological diseases which isevidence-based.

-How to select patients for the transplantprocedure according to indications,comorbidities, laboratory data andassessment of benefit/risk ratio.-Analysis of clinical and laboratory data ofpatients during and post-transplantation andsuggestion of appropriate measures to betaken accordingly.

C.Professionaland PracticalSkills

-Improving the professional skillsneeded for treatment of varioushematological disorders, includingexperience with use ofchemotherapy protocols andmanagement of side effects.

-Appropriate management of patients before,during the procedure and in the post-transplant period according to recentguidelines.-How to monitor and deal with the adverseeffects of conditioning regimens and othermedications used during and aftertransplantation.

0.51.5shrs

D. GeneralSkills

-Development and improvementof communication andleadership skills.

-To enhance communication skills with boththe medical team and the patients.





Others

Overview of HSCT Stem cell sources Pre-transplant evaluation Conditioning regimens and supportivecare

GVHD prophylaxis Transfusion medicine Engraftment

Infectious Complications Acute GVHD Chronic GVHD Thrombotic Microangiopathies Graft Failure Post-transplant Relapse



Case OSCE/OSPE


Others

Schedule of Assessment Mid-term ---

End of term 100%Distribution of Marks Written Exam 80 %

Practical/Clinical Exam --

Others log book+assignment20%

List of Textbooks and ReferencesLecture Notes -Lecture Notes

Course Text Books -Postgraduate Hematology

Suggested Extra Reading -Blood and Marrow Transplant Handbook-The EBMT Handbook

Journals and Periodicals, others

Course InstructorName: Prof.Manal El SoradySignature: Manal El Sorady

Program CoordinatorName: Prof. Nahla HamedSignature:

Program Director (Head of Department)Name: Prof . Manal El SoradySignature: Manal El Sorady



Faculty: Medicine

Department:


05151911Course Name: Immune deficiencies

Program in which the Course is Given: doctorate program in hematology

Number of Credit Hours 1 Theoretical Clinical/Practical

Course Aimsprovide updated knowledge and skills that allow Dealing successfully with common and difficult cases withdiseases of blood and bone marrow as well as Interpret hematological manifestations of medical diseasesand solid tumors.


Course ILOs


Identify Recent advances inthe field of diagnosis andmanagement of haematologicaldiseases including anaemia,coagulation disturbance andhaematological malignancies.

a11– update his knowledge on the impact ofsystemic disease on the blood and bone marrow.


Analyze, deduce, extrapolate &evaluate laboratory informationto establish diagnosis andappropriate treatment planning.

b1 Analyze laboratory testing results for theinitial management of common and unusualhematological disorders.

b2 Take decision in the diagnosis andappropriate treatment planning.

b4 apply multidisciplinary team work formanaging complication


c1 Plan professional courses toimprove practice and enhanceperformance of juniors asregards

c2Plan professional courses for appropriateuse of antibiotic regimens for treatmentand prophylaxis in the immunosuppressedpatient.

appropriate use of antibioticregimens for treatment andprophylaxis inimmunosuppressed patient.

D. GeneralSkills

Communicate with colleagues inother specialties effectively forproper diagnosis and treatmentof the patients.

-Advance his knowledge andinformation continuously usingdifferent printed and electronicsources.

d3-Communicate effectively with colleagues inother specialties for proper management of thepatients.d6-perform continuous self lifelong learningd7-Upgrade his scientific knowledge utilizing all

available sources.

Course Content (Units/Topics)




Others

Hereditary immunodeficiency Acquired immunodeficiency



Case OSCE/OSPE


Others


End of term 100 %

Distribution of Marks Written Exam 100 %Practical/Clinical Exam %Others %

List of Textbooks and ReferencesLecture Notes Print out



Journals and Periodicals, others BloodHaematologica

Course InstructorName: Prof. Dr Manal sorady

Prof.Dr ashraf alghandour Signature:

Program CoordinatorName: Prof.Dr. Nahla A. Hamed Signature:

Program Director (Head of Department)Name: Prof . Dr. Hassan Nafea Signature:



Faculty: Medicine

Department:


05151913Course Name: Integrated hematology II



Course Aimsprovide candidates with the updated skills that allow them to Deal successfully with common and difficultcases with diseases of blood and bone marrow as well as Interpret hematological manifestations ofmedical diseases and solid tumors.


Course ILOs



Analyze, deduce, extrapolate &evaluate laboratory informationto establish diagnosis andappropriate treatment planning.

Take decisions in variousprofessional situations ofhaematological problemsaccording to the available data

Apply evidence based medicinefrom updated reference.

b1 Analyze laboratory testing results for theinitial management of common and unusualhematological disorders.


b3 Explain planned treatment clearly to juniorstaff

b5 Apply evidence based medicine fromupdated printed and electronic reference.


D. GeneralSkills

Communicate with colleagues inother specialties effectively forproper diagnosis and treatmentof the patients.

Write and assess patient’sreports

-Advance his knowledge andinformation continuously usingdifferent printed and electronicsources.

d3-Communicate effectively with colleagues inother specialties for proper management of thepatients.d4-Perform leadership responsibilitiesd5- Write and appraise reports.d6-perform continuous self lifelong learningd7-Upgrade his scientific knowledge utilizing all

available sources.

Course Content (Units/Topics)




Others



Case OSCE/OSPE


Others


End of term 100 %Distribution of Marks Written Exam %


List of Textbooks and ReferencesLecture Notes




Course InstructorName: Prof. Dr Manal sorady

Prof.Dr ashraf alghandour Signature:

Program CoordinatorName: Prof.Dr. Nahla A. Hamed Signature:

Program Director (Head of Department)Name: Prof . Dr. Hassan Nafea Signature:



Faculty: Medicine

Department:


05151907Course Name:myeloma II



Course Aimsto provide candidates with the updated knowledge and skills that allow themtodiagnose and manage successfully Myeloma


Course ILOs


a1 – Identify Recent advances inthe field of molecular biologyin myeloma

a2 Identify recent advanes indiagnosis and management ofMyeloma

a5 – Identify recent advances in theclassification, natural history, molecularbiology, and therapeutic modalities ofhematological malignancies.


b1 Analyze & evaluate availablelaboratory information toestablish treatment plan ofMyeloma.

b2 Analyze & deduce laboratorytests to establish treatment ofuncommon types of Myeloma.

b4 Solve professional problemsrelated to Myeloma accordingto the available data

b5 Refer to evidence basedmedicine in managing cases

b6 Refer to updated reference indealing with difficult cases.

b1 Analyze, deduce, extrapolate & evaluatelaboratory testing results for the initialmanagement of common and unusualhematological disorders.


b5 Apply evidence based medicine fromupdated printed and electronic reference.

11


C1-Evaluate and improve methodsand tools used in management ofMyelomaC2–Plan professional courses to

improve practice and enhanceperformance of juniors asregards appropriate treatmentof Myeloma

C1-Plan professional courses of combinationchemotherapy regimens

D. General Skills d1-Perform leadershipresponsibilities in explainingcomplications of chemotherapy topatientsd2- upgrade his scientificinformation utilizing all availableprinted and electronic sources tomanage side effects ofchemotherapy

d1-perform full explanation of the sideeffects of chemotherapy to patients.





Others

Myeloma: Definition. Pathogenesis. Clinical features. Laboratory findings. Treatment. Monoclonal gammopathy of

uncertain significance.

Special types of myeloma: Plasma cellleukemia. Non-secretory myeloma.

Waldenstrommacroglobulinaemia. Heavy-chain diseases.



Case OSCE/OSPE


Others








Course InstructorName: Prof. Nahla AM Hamed Signature: Nahla AM Hamed.

Program Director (Head of Department)Name: Prof . Signature: YehiaGhanem



Faculty: Medicine

Department:Internal Medicine

Course InformationCourse Code: 05151909 Course Name:Hematological Manifestations of

Medical Diseases IIProgram in which the Course is Given Doctorate Degree in Hematology


Course Aimsto provide candidates with the updated knowledge and skills that allow them todiagnose

Hematological Manifestations of Medical Diseases

Intended Learning Outcomes (ILOs)Program ILO(refer to programmatrix)

Course ILOs


a11 – update his knowledge on theimpact of systemic disease on theblood and bone marrow.

a12 – update his knowledge inhaemostatic problems inpregnancy and solid tumors

a1 – Identify Recent advances in the diagnosisof Hematological Manifestations ofMedical Diseases

a2 Identify recent advances in treatinghaematological manifestations of medicaldisorders

a3 Identify updated knowledge inhaematological changes accompanyingsolid tumors

a4 Identify recent data in diagnosis andmanagement of haematologicalabnormalities during pregnancy


b4 apply multidisciplinary team workfor managing complication

b1 Communicates with his collagues in otherspeciality for early detection ofcomplications of Medical Diseases.

b2 Work in multidisciplinary team for bestresults in treatment of haematologicalmanifestations of systemic disease

11


c2 – Plan professional courses forappropriate use of antibioticregimens for treatment andprophylaxis in theimmunosuppressed patient.

C1-plan professional course for use ofantibiotics in cancer patientsC2- plan for professional course for treatinginfection in HIV

D. GeneralSkills

d3- Communicate effectively withcolleagues in other specialties forproper diagnosis and treatment ofthe patients.

d1- Communicate with different specialties atoptimum time for proper managing of thepatients.d2- Write and appraise reports





Others

Hematological Manifestations ofConnective tissue disorders

Hematological Manifestations of liverdisease

Hematological Manifestations of renaldisease

Hematological Manifestations ofendocrine disease



Case OSCE/OSPE


Others








Course InstructorName: Prof. Nahla AM Hamed Signature: Nahla AM Hamed

Program CoordinatorName: Prof. Nahla AM Hamed Signature: Nahla AM Hamed

Program Director (Head of Department)Name: Prof. Yehia Ghanem Signature: Yehia Ghanem



Faculty: Medicine


Course InformationCourse Code: 05151903 Course Name: Acute Leukaemias IIProgram in which the Course is Given Doctorate Degree in Hematology

Number of Credit Hours Theoretical Clinical/Practical

Course Aimsto provide candidates with the updated knowledge and skills that allow them to diagnose and

manage successfully acute leukaemic patients


Course ILOs


a4 Identify recent advances indiagnosis, classification andmanagement of acute andchronic leukemias in adults.

a13 update his knowledge regardingindications and management ofbone marrow transplantation

a1 – Identify Recent advances in moleculardiagnosis of acute leukaemia

a2 Identify Recent advances in prognosticfactors and their relation tomananagement

a3 –update his data concerning indication ofbone marrow transplantation

a4 –update his knowledge regardingposttransplant immunosuppressive drugs


b3 Explain planned treatmentclearly to junior staff

b1 Take decisions in treatment plan ofpatients

b2 Explain planed treatment and their sideeffects to other team member


c2 Plan professional courses forappropriate use of antibioticregimens for treatment andprophylaxis in theimmunosuppressed patient.

C1-Evaluate and improve uses of antibioticduring period of aplasiaC2–Plan professional courses to improvepractice and enhance performance of juniorsas regards appropriate use of antibioticduring aplasia

11

c5 – Evaluate and improvemethods and tools used instem cell transplantation

c6 - Evaluate and improvemethods and tools used indiagnosis & management ofhematological emergencies.

C3-Plan professional courses to improvemethods used in managing complications ofstem cell transplantationC4-evaluate and improve protocols used instem cell transplantation

C5-- Evaluate and improve diagnosticmethods of hematological emergencies

C6-plan professional courses formanagement of haematologicalemergencies

D. General Skills d2-communicates effectively withpatients performing transplantationand their family.

d4-Perform leadershipresponsibilities

d5- Write and appraise reports.

d1- Communicate with patients indicatedfor bone marrow transplantation as well astheir familiesd2- describe complications of bone marrowtransplantation to patients

d3-describe detailed follow up for junior staffd4- assess jobs ascribed to nursing staff

d3- Write referral medical reports.d4- assess medical reports written by juniorstaff





Others

Acute myeloid leukemia. Epidemiology of disease. Pathophysiology. Disease classification. Cytogenetics. Treatment. Future developments.

Adult acute lymphoblastic leukaemia: Introduction. Diagnosis. Clinical manifestations. Laboratory evaluation. Differential diagnosis. Initial evaluation and supportive

therapy. Chemotherapy. Stem Cell transplantation. Outcome of all subtypes and

prognostic factors. Minimal residual disease-practical

application in adult ALL. Treatment with monoclonal

antibodies. ABL tyrosine kinaseinhibitors in Ph/BCR-ABL-positiveALL.



Case OSCE/OSPE


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Course InstructorName: Prof. Hashim neanaa Signature:

Program CoordinatorName: Prof. Nahla AM Hamed Signature:




Faculty: Medicine


Course InformationCourse Code: 05151902 Course Name: Iron Metabolism, Iron Deficiency

and Disorders of Haem Synthesis,MegaloblasticAnaemia,HaemolyticAnaemias, Aplastic

Anaemia

Program in which the Course is GivenDoctorate Degree in Hematology


Course Aimsto provide candidates with the updated knowledge and skills that allow them to Diagnose and

manage successfully anaemic patients


Course ILOs


a1 – Identify recent advances in thecauses, presentation,complications, diagnosis andmanagement of different types ofanemia.

a1 – Identify Recent advances in genetic basisof thalassaemia

a2 Update his knowledge in the field ofdiagnosis of anaemia

a3 Update his knowledge in management ofdifferent types of anaemia

a4 Update his knowledge regarding treatmentof paroxysmal nocturnal haemoglobinuria

a5 –update his knowledge regarding recentdrugs used in the field of anaemia

a6 Update his knowledge in the use ofhydroxyurea

a7 Update his knwoldge regarding screeningfor thalassemia

a8 Update his knowledge regarding druginduced haemolytic anaemia

a9 Identify recent advances in Molecularmechanisms of normal iron

a10– identify recent advances in invasive

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a3 – Identify recent advances indiagnosis and management ofinherited and acquired bonemarrow failure.

assessment of tissue iron overloada11Update his knowledge in the use of

iron chelation therapy

a12Update his data in use ofimmunosuppressive therapy in aplasticanaemia

a13Update his knowledge in use of bonemarrow transplantation in aplasticanaemia


b5 Apply evidence based medicinefrom updated printed andelectronic reference.

b1 Take decisions in various professionalsituations related to anaemic patientsaccording to evidence based medicine

b2 Solve advanced problems related totreatment of sickle cell anaemia

b3 Solve advanced problems related todiagnosis of pancytopenia

b4 Take decisions in treatment of infections inaplastic anaemia

b5 Solve problems related to diagnosis of ironoverload


c5 – Evaluate and improvemethods and tools used in stemcell transplantation

c6 - Evaluate and improvemethods and tools used indiagnosis & management ofhematological emergencies.

C1-evaluate the tools used in use of bonemarrow transplantation in thalassaemia

C2-evaluate and improve methods use intransplanting hepatitis c positive patients

C3-improve methods used in preventingsickle cell crisisC4- improves methods used in treatingsickle cell crisis

D. GeneralSkills

d6-perform continuous self lifelonglearning

d7-Upgrade his scientific knowledgeutilizing all available sources

d1-perform self learning all through his lifed2- Plan courses for junior staffd3-shares in scientific conferences

d4-Upgrade his scientific knowledgecontinuously using available printed sourcesd5- perform updating his knowledge throughelectronic sources.d5-perform researches in his field





Others

Distribution of body iron. Cellular ironhomeostasis. Normal iron balance. Ironabsorption. Internal exchange. Diagnosticmethods for investigating iron metabolism.

Iron deficiency anaemia. Causes of iron deficiency. Management of iron deficiency.

Haem synthesis. Pathological alterations inhaem synthesis.

Megaloblasticanaemia: Introduction. Underlying basic science. Clinical features. Haematological findings. Cobalamin. Cobalamin analogues. Causes of cobalamin deficiency. Diagnosis of cobalamin deficiency.

Tests for the cause of cobalamindeficiency.

Folate. Causes of folate deficiency. Diagnosis of folate deficiency. General management of

megaloblasticanaemia.Prophylactic folic acid.

Megaloblasticanaemia not due tocobalamin or folate deficiency oraltered metabolism.

Other nutritional anaemias.

Haemolyticanaemias Disorders of red cell membrane. Inherited disorders of hemoglobin.

Sickle cell disease. Acquired haemolyticanaemias Immune haemolyticanaemias.

Warm-type autoimmunehaemolyticanaemias. Cold-typeautoimmune haemolyticanaemias.

The non-immune acquiredhaemolyticanaemias.

Inherited aplastic anaemia/bone marrowfailure syndromes:

Introduction.

Fanconianaemia. Dyskeratosiscongenital. Shwachman-Diamondsyndrome. Diamond-Blackfananaemia.

Congenital and cyclicalneutropenias.

Thrombocytopenia with absentradii. Congenital amegakaryocyticthrombocytopenia.

PNHAcquired aplastic anaemiaPlease check () the appropriate method.


Case OSCE/OSPE


Others








Course InstructorName: Prof. Hassan Nafea

Hassan Nafea

Program CoordinatorName: Prof. Nahla AM Hamed

Nahla AM Hamed

Program Director (Head of Department)Name: Prof. Yehia Ghanem

Yehia Ghanem



Faculty: Medicine

Department: Internal Medicine

Course InformationCourse Code: 05151909 Course Name: Blood Transfusion II

Program in which the Course is Given Doctorate Degree in Hematology


Course Aimsto provide candidates with the Recent advances inthe field of blood transfusion


Course ILOs


a8 – update his knowledge in thepharmaceuticals and bloodproducts available for themanagement of excessivebleeding.

a9 – update his knowledge in thefield of blood transfusion.

a1 – Identify Recent advances in the indicationof blood transfusion.

a2 Identify recent advances in managingcomplications of blood transfusion

a3 Identify recent advances in Transfusion-Related Acute Lung Injury

a4 –update his knowledge in artificial plateletsubstitutes

a5 Identify recent advances in therapeuticapheresis

a6 Update his knowledge in alternative to bloodtransfusion

a7 Update his knowledge in use of anti Da8 Update his knowledge in platelet

refractorinessB. Intellectualskills


b1- take decision in early diagnosis ofcomplications of blood transfusionb2- take decision in treatment ofcomplication of blood transfusion

2


C3-Plan professional courses forcomplications of blood transfusionappropriately

C1-Plan advanced courses for junior staffconcerning management of complications ofblood transfusionC2-solve problems related to complications ofblood transfusion

D. GeneralSkills





Others

Blood component transfusion indications Complications of blood transfusion Alternative to blood transfusionTherapeutic apheresis



Case OSCE/OSPE


Others



Practical/Clinical Exam %Others %





Course InstructorName: Ass. Prof. Nadia Zaki Signature:

Program CoordinatorName: Prof. Nahla AM Hamed Signature:




Faculty: Medicine


Course InformationCourse Code: 05151908 Course Name: Homeostasis IIProgram in which the Course is GivenDoctorate Degree in Hematology


Course Aimsto provide candidates with the updated knowledge and skills that allow them todiagnose and manage

successfully haemostatic disorders


Course ILOs


a7 – Identify recent advances in thediagnostic methods used in theassessment and themanagement congenitalcoagulation and plateletdisorders.

a8 – update his knowledge in thepharmaceuticals and bloodproducts available for themanagement of excessivebleeding.

a1 – Identify Recent advances in the field ofdiagnosis of haemostasis

a2 Identify updated knowledge in themanagement of haemostatic disorders

a3 Updating his knowledge regardingtreatment of von Willebrand diseaseaccording to molecular data

a4 –update his knowledge regarding the drugsused in the field of haemostatic disorders

a5 Update his knowledge in indication andside effects of blood products

a6 Update his data regarding management ofbleeding disorders during pregnancy

a7 Identify recent advances in drug inducedthrombocytopenia


b1 Analyze, deduce, extrapolate &evaluate laboratory testingresults for the initialmanagement of common andunusual hematological disorders.

b2 Take decision in the diagnosis

b1 Analyze & evaluate laboratory data to planfor treating platelet disorders

b2 Analyze & evaluate results of laboratorytests to treat coagulation abnormalities

b3 Take decisions in various professional

12

and appropriate treatmentplanning.

b5 Apply evidence based medicinefrom updated printed andelectronic reference.

situations of haemostatic disordersb4 solve problems related to haemostatic

disorders according to the available data

b5 Apply treatment according to evidence basedmedicine

b6 Refer to updated referencein rarepresentations


c4 – Plan professional coursesfor use and monitoring ofanticoagulation

C1-Evaluate and improve methods and toolsused in management of haemostatic disordersC2–Plan professional courses to improve

practice and enhance performance ofjuniors as regards appropriate treatment ofhaemostatic disordersand monitoring ofanticoagulants

D. General Skills d7-Upgrade his scientific knowledgeutilizing all available sources.

d1- Upgrade his scientific data using recenttextbooks and journals.d2- select appropriate idea for research work





Others

Normal haemostasis: Blood vessels.Platelets. Coagulation factors. Naturallyoccurring inhibitors. Fibrinolysis.

Inherited bleeding disorders: Haemophilia A. Haemophilia B. Gene therapy. Von Willibrand disease. Congenital platelet disorders

Acquired coagulation, platelet & vascularbleeding:

Disseminated intravascularcoagulation.

Coagulopathy & massive bloodloss.

Vitamin K deficiency. Idiopathic

thrombocytophricpurpura. vascularpurpuras.

Inherited thrombophilia.. Acquired venous thrombosis. TTP. Please check () the appropriate method.


Case OSCE/OSPE


Others








Course InstructorName: Prof. Mohamed El-Dafrawy Signature:





Faculty: Medicine

Department: Internal Medicine

Course InformationCourse Code: 05151901 Course Name: Haemopoiesis II

Program in which the Course is GivenDoctorate Degree in Hematology


Course Aimsto provide candidates with the Recent advances inthe field of stem cells research


Course ILOs


a2 Identify recent advances in stemcell research.

a1 – Identify Recent advances in the field ofstem cells.

a2 –update his knowledge regarding growthfactors

a3 Identify recent advances in therapeutic usesof haematopoeitic growth factor

a4 Update his knowledge in T lymphopoiesisa5 – Identify recent advances in B cell

development.a6 Update his knowledge in cytokinesa7 Update his knowledge in therapeutic

implication of cytokinesa8 Identify recent advances in complications

of use of erythropoietina9 Update his knowledge in signal

transduction pathwaysa10Update his knowledge in cell surface

markersB. Intellectualskills

b3 Explain planned treatment clearlyto junior staff

b1- explain use of myeloid growth factors inimmunosuppressed patients to junior staffb2- discuss recent indications of

2

erythropoietin to junior staff


D. GeneralSkills





Others

Introduction Sites of haemopoiesis The stromal microenvironment Stem cell trafficking Organization of haemopoiesis Haemopoietic growth factors andreceptors

Clinical applications of stem cellresearch.



Case OSCE/OSPE


Others



Practical/Clinical Exam %Others %





Course InstructorName: Prof. Manal Elsorady





Faculty: Medicine


Course InformationCourse Code: 05151905 Course Name: Stem Cell Disorders IIProgram in which the Course is Given Doctorate Degree in Hematology


Course Aimsto provide candidates with the updated knowledge and skills that allow them todiagnose and

manage successfully stem cell disorders


Course ILOs


a10 – update his knowledge inclassification of myeloproliferativedisorders, the required diagnosticmethods and the therapeuticoptions.

a1 – Identify Recent advances in the field ofdiagnosis and management of stem celldisorders

a2 –update his knowledge regarding the drugsused in the field of stem cell disorders


b1 Analyze, deduce, extrapolate &evaluate laboratory testing resultsfor the initial management ofcommon and unusualhematological disorders.

b1 Analyze & evaluate laboratory informationto establish diagnosis and appropriatetreatment planning of unusual stem celldisorders.

b2 Take decisions in various professionalsituations of problems related to stemcell disorders according to the availabledata


c1 - Plan professional courses ofcombination chemotherapyregimens.

C1-Evaluate and improvemethods and toolsused in management of stem cell disordersC2–Plan professional courses to improvepractice and enhance performance of juniorsas regards appropriate treatment of stem celldisorders

12

D. GeneralSkills

d7-Upgrade his scientific knowledgeutilizing all available sources.

d1- update his data using available journalsof the specialityd2- update his knowledge in treatmentutilizing all related web sites





Others

Myelodysplastic syndromes. Cytogenetics. Investigations. Classifcation. Pathogenesis. Prognosis. Management.

Myeloproliferative disorders: The polycythaemia. Polycythaemia rubra vera. Essential thrombocythaemia. Idiopathic myelofibrosis.



Case OSCE/OSPE


Others








Course InstructorName: Prof. Nahla AM Hamed





Faculty: Medicine


Course InformationCourse Code: 05151904 Course Name: Chronic Leukaemias IIProgram in which the Course is Given Doctorate Degree in Hematology


Course Aimsto provide candidates with the updated knowledge and skills that allow them todiagnose and

manage successfully chronicleukaemicpatients


Course ILOs


a4 – Identify recent advances indiagnosis, classification andmanagement of acute andchronic leukemias in adults.

a14– update his knowledgeregarding chemotherapyregimens used in themanagement of hematologicalmalignancies.

a1 – Identify Recent advances in thediagnosis of minimal residual disease inchronic lymphocytic leukaemia

a2 Update his knowledge in therapeutic planin chronic myeloid leukaemia

a3 –update his data in the recent drugs usedin chronic myeloid leukaemia

a4 Identify recent advances in indications andside effects of classes of tyrosine kinases


b1 Analyze, deduce, extrapolate &evaluate laboratory testingresults for the initialmanagement of common andunusual hematological disorders.

b1 Analyze, deduce, extrapolate & evaluatelaboratory information to establishdiagnosis

b2 Plan for appropriate treatment of chronicleukaemic patients.

b3 Take decisions in various professionalsituations of problems related tochronic leukaemia according to theavailable data

b4 Apply evidence based medicine fromupdated reference.

11


c1 - Plan professional courses ofcombination chemotherapyregimens.

c2 – Plan professional coursesfor appropriate use ofantibiotic regimens fortreatment and prophylaxis inthe immunosuppressedpatient.

C1- plan professional course forguidelines in treating chronic myeloidleukaemia

C2- plan professional course for updatedtherapy in chronic lymphocyticleukaemia

C3- plan for professional courses fortreatm ent of immunosuppression onfludarabine therapy

C4-plan for professional courses fortreatment of immunosuppression inchronic lymphocytic leukaemia

D. General Skills d1- perform full explanation of theside effects of chemotherapy topatients.

d5- Write and appraise reports.

d1- Perform explanation of side effects oftyrosine kinases to patientsd2-perform explanation of side effects offludarabine to the patients

d3- Write and judge medical reportsefficientlyd4-select the appropriate time for referal





Others

chronic myeloid leukaemia Introduction. Classification. Cytogenetics. Molecular biology. Clinical features. Haematology. Management :Treatment decisions

for newly diagnosed patients inchronic phase. Management ofchronic myeloid leukaemia inadvanced phase.

Variants of chronic myeloidleukaemia.

Chronic lymphocytic leukaemia and other

B-cell disorders: Introduction. Methodology for diagnosis.

Chronic lymphocytic leukaemia.Management.

Prolymphocyticleukaemia.

Hairy cell leukaemia. The leukaemic phase of low-grade NHL. Please check () the appropriate method.


Case OSCE/OSPE


Others








Course InstructorName: Prof. Hashim Naenaa



Documents

University: Alexandria Faculty : Medicine Program ... · anemia. a2 – Identify recent advances in haematopoiesis and stem cell research. a3 – Identify recent advances in ... 3