U n lo c k t h e f U l l p ow e r o f yoU r S ynA p t S yS t em

SYNAPT™ HDMS™ has defined a new category in mass spectrometry by providing researchers

with the ability to differentiate samples based on size, shape, and charge, as well as mass. Since

its introduction, many leading scientists have taken advantage of the unique benefits of high-

efficiency ion mobility separations in their research.

Dozens of scientific papers have been published based on research with SYNAPT HDMS Technology,

which range in focus from conformational analysis and separation of different compound classes to

increased analytical peak capacity and more complete structural characterization.

You can now benefit from the capabilities of the SYNAPT System with the state-of-the-art High

Definition Imaging (HDITM) MALDI platform or the enhanced power and versatility of DriftScope™

Informatics 2.0 Software.

Whether you use your SYNAPT System to achieve a better understanding of biological systems,

manufacture products more productively, or develop the drugs of tomorrow, there’s never been

a better time to consider upgrading your SYNAPT MS System to full SYNAPT HDMS or MALDI

SYNAPT™ HDMS capability.

DriftScope 2.0 Software Unlock the full power of SYNAPT High Definition Mass Spectrometry™ and high-efficiency ion

mobility separations. DriftScope 2.0 Software:

n Automatically and comprehensively detects components from 3D or 4D datasets to better

facilitate data interpretation.

n Delivers new levels of specificity, information content and productivity in your research for

your application, from small molecules to proteins, polymers, tissue, or even crude oil

n Provides new levels of accessibility and reproducibility for users of all levels.

The figures above show results from the IMS/MS (drift time versus m/z) analysis of crude oil before (left) and after (right) the use of DriftScope 2.0 Software. As shown, the automated peak detection in DriftScope 2.0 comprehensively reveals all components within any SYNAPT HDMS data, increasing the apparent specificity of the analysis and rapidly revealing information that was previously unobtainable.

Be aSSureD

ChooSe WaterS GloBal ServiCeS

Waters Global Services focuses on optimizing Waters products with superior service, support, upgrades, training, and Waters Quality Parts®.

Proven SatiSfaCtion

For the eighth consecutive year, an independent quality auditing firm ranked Waters Global Services best-in-class in providing expert technical knowledge, quick resolution of system issues, and process support.1

1 Achievement in Customer Excellence Award, CustomerSat, Inc., 2007, 2008; NorthFace ScoreBoard Award sm, Omega Management Group Corporation, 2000-2006.

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Waters is a registered trademark of Waters Corporation. The Science of What’s Possible, SYNAPT, HDMS, HDI, DriftScope, and High Definition Mass Spectrometry are trademarks of Waters Corporation. All other trademarks are the property of their respective owners.

©2009 Waters Corporation. Produced in the U.S.A. February 2009 720002952EN PC-PDF

To request a quote, contact your local sales representative. For more details about MS upgrades,

visit the Service & Support section of www.waters.com and click on Upgrades – MS Upgrades.

hDi MalDi MALDI SYNAPT HDMS System takes advantage of high efficiency ion mobility separations and

Driftscope 2.0 software to:

n Allow detection of compounds in the absence of isobaric interferences

n Dramatically enhance sensitivity from complex matrices

n Separate and image compounds of different classes.

HDI MALDI delivers significantly increased specificity and confidence in spatial distribution of

compounds in a variety of matrices.

the true Potential of your SynaPt SySteM Will SurPriSe you.

To learn more about how to upgrade to SYNAPT HDMS or MALDI SYNAPT HDMS, visit www.waters.com/SYNAPT and read about DriftScope 2.0 Software and HDI MALDI, review the comprehensive list of peer-reviewed journal articles, or download application notes and product information.

The image on the left shows the spatial distribution of a component in a rat kidney section from MALDI imaging using a conventional MS approach. The image on the right shows how the increased specificity of HDI MALDI provides more accurate, clear, and confident results.