USDA APHIS | Home Landing Page€¦ · 83-R-0028 1181 1 3. REPORTING FACILITY (LiU 31 1-bonr whas anlrnis wn, hwed wured in .dual nrursh, leNn0. leachhp, or uWnaOtim. held for !hue

This report is required by law17 USC2143). Fallure lorepataccordlw lo lhe r ~ v l a l i m r can S e reMme SJ~C lor Interagency Repon Conlrd No result in an order loceaw and desist and la be sub@ la penaltter as powded la in Seam 2150. addlli-i mlormlon. OIBMK)A.AN

UNITED STATES DEPARTMENT OF AGRICULTURE I. REGISTRATION NO. CUSTOMER NO. ANIWL AND PUNT HEALTH INSPECTION SERVICE 93-R-0016 1189 FORM APPROVED

OMB NO 05790036

I . ~ - ~ ~~~~-

(310) 222-3601

3. REPORTING FACIUTY (List all 1a;sttonr *re antmlr w e mused o u x d m aaval reaearm. issling. leablmg. or ewdmotattm, a held Iw mere plrpcses Altam add8trlnal rheeb if nesesrav.1 1

FACILm LOCATIONS(sPes]

See Anached Listing

ANNUAL REPORT OF RESEARCH FACILITY (TYPE OR PRINT)

I I I I

5. Cats I 0 I

I 2. HEAWUARTERS RESEARCH FACIUTY (Name anorMdrsu. as rcg~sludv*h USD.4

ndudc Z@ Code] HARBOR-UCLA RES (L EOUC INST 1124 WEST CARSON STREET TORRANCE CA 90502

I a. NonHvman Primates I I I I I n

6. Guinea Pigs

7. H a m r t m

8. RabWs

10. Sheep 130 130 I I I

1 1 Pigs I I 73 1 73

12. Omer Fann Animals I

9

I I - --

Cows 3 3

13. Mher Animals

41 me anmdmo uotewrian mars nvvrh fadlity hsr appopia~ ~ ~ l y t o n a n me m Y m ddqwt. M n a r y a r . and o w- me aaqmcyd d h e ~ aweas d ."*rsl car. ."a Yfl

I CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL i

983

(Chief Executive Officer or Legally Responsible instltutlonal official) I cddymat w a h is trua. caned and complete (7 U S C S e a m 2143)

I DATE SIGNED

0

0

992

Facility Locations

Buildings C-I, C-I Annex, C-2, D-I, E-1, E-1 Annex, F-1, F-1 Annex, F-2, F-7, RB-I, RB-2, RB-2 Annex

Amroved Variance to Regulations

A variance has been issued by the Animal Care and Use Review Committee on October 16, 2003 to house sheep in metabolic cages. The metabolic sheep cages have a floor space of 1 I square feet, this is 4 square feet less than the recommendation. These cages are used for sheep with chronic catheters in place generally both fetal and maternal catheters. The animals need to be confined to a safe, clean environment because of the catheters. The animals can move freely in the cages and can turn around. The animals are housed in the metabolic cages for less than two weeks

(b)(6), (b)(7)c

aOd110na "1-l yl n UN-FO S l A T E S OtPARlMENT OF AGRCr.TLRE 1. REGSTRATION NO. CUSTOMER NO. %hllA4L AhD PLANT n€4rTn lNSPECTlON SERVCE 93-R0018 1188 FORM APPROVED

OMR hO 051WC.36

41 me atlend~nQ vetennanan la this research laduty ha9 sppmpriste auVlonty t o m w e IhepmUrIm of adequate v e t e n ~ y sars and to o m - the adeguaqdaher aspects d anom1 care ~d use

I CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL 1


~ - .- ~- (Chief Executive Oflicer or Legally ~esponsible lnrlitulional official)

DATE SlGhED

I

2. HEAWUMTERS RESEAFXH FICILITV (Name snd Address. ar ,-shred i*lh USDe n d v d ~ 29 C ~ J

BAYER CORPORATION P 0 BOX 1888 BERKELEY. CA 94701 (510) 7054848

/ ' & / ~ ~ 1 DQUARTERS

(AVO 91)

5. RwoRrtNO FACICILIIY ( L ~ I a11 locat~onr rrhers m m l s m h o u r o d aured m aaual rerearsh. lutmg. Iesshtnp. a c~penmntalton. a held lorthere purposes Attach Mdillomt she& 11 nne- 1

F A C I m LOCATK)NS(rXesI

See Attached Llstmg

NOV 2 1 ;'A 1

I I HEIWWTW RESEARCH FACILKV (N- d A & h v r ~ as w d m d mth U S M

(TYPE OR PRINT) UNIVERSITY OF SCUTHERN CALIFORNIA UNIVERSITY PARK LOS ANGUES. CA 8WB9

I). Numad m b a p m. rmdUmbJ. u hddh-uYh urt*a*.mo. upmam. -. = -b*nd PJdlorludl p.PoI0..

(Chlef Executive Otflcer a Lesally Responsible InsUtuUonaI ~(fidal) I o a m h l ~ l m s . b a e L s b u a m r n d a d ~ n U . S . c . S ~ 2 1 4 5 )

( DATE SIGNED

UNITE0 STATES DEPARTMENT OF AGRICULTURE 1. REGUTK4TK)N NO. CUSTOMER NO. ANIMAL AND PUNT HEALTH INSPECTION SERVICE 83.R.0025 1184

a r e now c l o s e d and db :PORT OF ANIMALS USED 81 OR UNDER W M R M M

sn,nai, WmQ An,mis Cov"ed By TkAn4t.i mdlt lmed, w

wemn Rcguiauw held io-wa m 1eashrm wme a i p a m n m .

yeturad1wwFh

FORM APPROMD


d s a a iomian~mslr tnl-u~m d he 1k.m no, r-#ch. "MWW m e i p a n a s . wrpay. w iuu (A" e d a m m of

M . ~ d W d u W ~ h 0 1 M m n M s ~ a d p m . m n p ~ l nnp 6%- rr. .muandme m a w 'mi d w s nol c.& r r Mrn dhm. rnl h ."- lO I,", re-,

OM0 NO. 057PW36 I I

2. HEADOUAQTERS RESEARCH FACILITY (Name and Addrsrs. arnpiaHM rn USDA. irduae ze -I

CALIFORNIA DEPT. OF HEALTH SERVICES 850 MARINA BAY PARKWAY. ROOM 8153 ANIMAL CARE AND USE PROGRAM RICHMOND LABORATORIES CAMPUS RICHMOND. CA 84804 (510) 307-9822

TOTAL NO. OF INIMALS

(CON. C . D + 9

3. REPORnNG FACILITY (LSI ell im l8ms haa animls- homed mused in sd lv i -arch. terunp. -chino, or qw immla l im , w held fu b pu-. AtUch addttimel sheets if no-v.)

F M l L W LOCATiONS(S#eSl

See Attachsd Listing

An 'mals w e r e housed o r u s e d i n D e p a r m e n t f a c i l i t i e s i n F a i r f i e l d and R e r k e l y u n t i l January and May, 2 0 0 3 , l r e s p e c t i v e l y . These f a c i l i t i e s

SlGhA ATE SIGNED

I

APHIS i~.~la~..wi FORM ia.21 I. *SOI.I~ PART I -HEADQUARTERS (AUG 91)

1 1 i i Xi03 J

. .

J meus li mcesrary.) I F U U l Y ~ O c A T ~ s f ~ e s ~

Sse Atladed Lisling


FORM APPROVED OM0 NO 057900X

UNITE0 STATES DEPARTMENT OF AGRICULTURE ANIWL AND PUNT HEALTH INSPECTON SERVICE

2. HEIWUARTW RES£ARCH FACILITY (Name and AWRSI. as r&b.d v l h USD* muse zw cod01

CALIFORNIA INSTITUTE OF TECHNOLOGY M I L CODE 156-28 1200 E. CALIFORNIA BLVD. PASADENA. CA 81 125 (028) 385-4857

1. REGISlRAnON NO. CUSTOMER NO. 83-R-0028 1181

1 3. REPORTING FACILITY (LiU 31 1-bonr whas anlrnis wn, hwed wured in .dual nrursh, leNn0. leachhp, or uWnaOtim. held for !hue PYrPOKI. ABdl eddillml

4) me alladinQ mtamnsn formis msssrch hdiity has s m p i * t e aumority to en- t~ @Urn d sdaquaic veterinuy rsre and lo - the adeqwwd mer a-b d animal me and use.

CERTIFICATION BY HEADQUARTERS RESEARCH FAClLlM OFFICIAL (Chlef Executive Ofiicer or Legally Responsible institutional official) 'i : !

ib . . - . . Q

DATE SIGNED

PART 1 - HEADQUARTERS (AUG 91)

w'

7 1 s mpOl ls m i m i by law I7 USC 2143) Fadun io rewvl asmdmg tome rqumtmr can S e n r m Y d a f o t =UII in an war ID cease and dgl* and to k rum lo PMaitln as w e d for in seam 2150

Maagsnsy Ram Canm No sddluml lm~mshm 01W-LWA-AN

UNITED STATES DEPARTMEW OF AGRKULTURE +. REGISTRATKIN NO. CUSTOMER NO. ANIM*L AND PLANT HEALTH INSPECTON SERIllCE 03-RM)30 8229 FORM APPROVED

OM0 NO 05794036

ANNUAL REPORT OF RESEARCH FACILrrY (TYPE OR P R I M )

4 Dogs

5 cats

6 Guinea Pga

7 mrnsiem

1 12.OUmr Farm Animals 1 I I 1

I 2. nUWWRTERS RESEARCH FICIL(n fNam*ndMdnss, asr@lwdnm USW

Childrents . . aklar 747 52NO STREET OAKLAND. CA 84609

0

0

0

n 8. RaMs

9. Non-Human Primates

10. sheep

11 Pigs

I 13. Other Animals 1 I I I

d

- 0

0

0

0

4) Theilnnd8np wteinakn tor Vwr researe fa611Wh.r appoplme 8utmW lo msun ho prwiran dedeguaIe Wmry u r e acd m wase me adqlucydomr a r m daruml sue and uu.

I CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL I (Chlef Executhre Officer or Legally Rmponsibla Institu(iorul ofRclal)

SIGNATURE I DATE SIGNED

I ( q q / d d APHIS FOR 1 - HEADQUAR~RS

(AVO 91)

This repM i t required by lau(7 USC 21431. Failure to repel %coding lo the reguiatior. can See nvase side for Interagency Rspwt m l m l No (2 icruil in an -to mse rn Wis t ma to b+ s u w to p m i t i a as m d a d h~ in -on 21M. aaal~iowl in~wmaon. 0180-wA+N * \ UNITED STATES DEPARTMENT OF AGRICULTURE 1. REGISTRATDN NO. CUSTOMER WO.

ANIMAL AND RANT HEALTH INSPECTON SEWICE 93-R.W32 1179 FORM APPROVED O W NO. 057900H I

FACILITY LOCATIONS(~s1 See Attghed Listiw


15. Cats

2. HEUlOUIRTERS RESEUICH FACIUTY (NamemeAboress, ss rspulered USD*. nclude ID Cadel

CEDARS-SINAI MEDICAL CENTER am0 BEVERLY BLVD.. DAVIS 7W4 LOS ANGELES. CA 90048

6. Guinea P i s

7. Ham-

8. Rabbm

9. W u m a n Primates

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL

SIGNATURE I OAT€ SIGNED

1 1 . ~ 1 s

12. Cmer Farm Animals

12

129

12

129

293 293

CEDARS-SINAI MEDICAL CENTER

ADDENDUM TO USDA ANNUAL REPORT

RE: Annual Report of Research Facility Federal Fiscal Year: October 1,2002 - September 30,2003

Registration Number: 93-R-0032 Customer Number: 1179

On the attached USDA Annual Report form, Cedars-Sinai Medical Center is reporting 293 pigs used in research, testing, and training d&ng the Federal fiscal year October 1,2003 to ~e$emb& j0, 2003.

Death as an Endvoint Of the 293 pigs reported on this Annual Report, 34 were used in protocols for which "Death as an Endpoint" is anticipated for several of the animals. These studies involve the search for, and verification of therapies to treat severe acute liver failure. It is important to note that not all of the pigs used in these experiments experienced "death as an endpoint"; some of the pigs were in groups that underwent nonsurvival surgical procedures. Nevertheless, all of the animals for which death was an endpoint had procedures (with appropriate anesthesia andlor analgesia) to induce liver failure.

During liver failure, the pig succumbs while in deep hepatic coma. It is the understanding of the CSMC IACUC that deep hepatic coma is similar to a state of general anesthesia, and therefore the comatose pigs do not perceive pain or distress. Thus, these pigs have been reported in the " D stress column.

Addendum to USDA Annual Report Federal Fiscal Year Ending 09130103

Page 1 of 1

This repm is required by l a ( 7 USC 2143). Failure 10 r a m accading m me mguiatiora can SO(I m-e Ud8 fa klemgency RepM CMIW No m u l l in an -10 sass a M desist and to be s u W lo p a ~ l t i a as pmndd f a in m i m 2 1 s . Mditimal i nha t i on . OlBO-WA-AN

UNmDSTATES DEPARTMENT OF AWUCULTURE 1. REGISTRITIDN NO. CUSTOYR NO. ANIMU AN0 PLANT HEALTH INSPECTION SERVICE 935(.0034 1178 FORM APPROVED

OMB NO. 05790036 1

I REWRl OF ANNALS USED BY OR UWER CO(ITROL OF RESEARCH FACIUTI ~ A ~ ~ ~ ~ * D M ) ~ ~ ~ ~ ~ . u B A P ~ ~ S F O R M 702M)

L I F. I

ANNUAL REPORT OF RESEARCH F A C I L I N (TYPE OR PRINV

2. HEIWUARTERS R E S W C H FACIUIY (Name a n d A d w s . a s r w d M h USm. Mudo zc Coael

CALIFORNIA PACIFIC MEO. CTR. 2200 WEBSTER STREET. SUIT514 SAN FRANCISCO. CA 941 15 (4153ECU1184

I 8. Rabbits

1. REPORTING FACIUTY (Us1 d l lxat icnt * r e m m i s were h m d w mad in m u a l -arm, teshnp. teaming. a swamantatim, w heid for these pumcoes. Altam additsmai Uwar i n w r r a v . )

F A C I ~ LDCATKINS~SW~

See Attaehsd Listiw

5. Cats

6. G u i w P i p

7 , Hamstem

1


10. Sheep I

1 12. M h e r Farm Animals I I I I I I

1

11. Pips

1 13. Other Animals 1 I I 1

3

I

41 The anmding Memanan fw mu -m fatilih h n awmpiat. a v t w w nsunthe pmulsim d adsgum vttonmr, a r e Md lo ovenae me adequacy of oha .spec& Of mimi C.R end usa.

I CERTlFlCATlON BY H W Q U A R T E R S RESEARCH F A C I L I N OFFICIAL I

3

I I I I I

(Chief Executive OfIicer or Legally Responsible lnstkutlonai official)

S )

A ART 1 . HEALIQUARTERS

( W G 91)

m#r r e p ? !s rqulred by law (7 USC 2143). Failure to mpm amoldkg lo ma r~u l s l l on r csn Sm rn sldefw :'

Iniag+my uew Cmird r w l l m an oraa l o cease and dais1 m a to ba s u w 10 pnsltla .I pmuidsd l w in M m 2lYI. addilional inf-iim. 0180-DOA-AN

UNITED STATES DEPARTMENT OF AGRICULTURE 1. REGDTRLTKWI NO. CUSTOMER NO. - ANIMAL AND PlANT HEAlTH INSPECTION SERVICE 93-R-9148 1158 FORMAPPROMO

OM0 NO. 057WQ36

I ,-", -.-" a. REPORTING FIClUTY (Lls131 loot iom uhere anlmls was h w d or arm dm acluai rasssrd?, tamp. leachima, w smsnmn80m. w heid lw msss pl-. A i m addilional

sheem ~lnecesaw )

FAClLm L0CITI)WU.u.I


4) me anenamp wmnnmar for lhlr march facllily has a p p m l e a u l h m l y to m r e me m u o n dsdcPlula vsb l rov cars and lo o m Vn s a q u r s y d m a t p n r d amrnsl care and UM

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL (Chiel Ex.cutlve mmr or Legally RH~onrlble lnstitutionrl official) I

I 2. n E I W U m R S RwE~RCH FACILITY a n d ~ ~ n s r , as m # s m e d ~ h USDA.

&dud. Z@ coal CRITICAL CARE RESEARCH. INC. 10743 CIVIC CENTER DRIVE RANCHO CUCAMONGA. CA 91730 I-3 -7 .m"

ANNUAL REPORT OF RESEARCH FACILITY (7YPE OR PRINT)

Sai.Diego Zoo Wild-Animal La rk Escondido, LA

I 2. W W J I R I W I-H FAClUlV (Nw M d A d b . I I WRahlmd M h U S D A

-2ec-m~ Z O O C C G I ~ SOCIETY OF SAN OlEW P. 0. BOX 120551 SAN DIEGO. CA 92112 (619) 567-3941

mms 81 n-v) I FACILmLc€AmI(*,J

SIGNATU I DATE SIGNED

I 3. RWRnWo FACILm 1b.1 dl lmuon) mere minds .rrn busad w u w m auwl munh. Wno. i161lm. w.q*nmUIDn. WW Iu U.Y pi-. Altlch IddlUmal

See Atached Llsllng San Diego Zoo San Diego, CA

APHIS ~ 0 T 1 -HEADQUARTERS (AUG 91)

Bear Country, USA Rapid C i ty , SD

CONTINUATION SHEET FOR ANNUAL REPORT '

OF RESEARCH FACILITY ZOOLOGICAL SOCIEN OF SAN DIEGO P. 0. BOX 1x1551

(TYPE OR PRINT) SAN DIEGO. CA 821 12 610 5573941

himl Cowed

UNITE0 STATES OWARlUEhl OF AGRICJLNRE 3. rWWlRATOW NO. CUSTOYR W. ANIUA. Ah0 PLANT HEALTH IMPECTION SERVICE W-RO151 11%

4) Tkatmdng nlennadm fw mo, mearch fsahty mr IWWM mummy m mrun the povldon dadequm wmrurym nd m o m x a iha adqwcy cdnhar .r*Od.nlrrul -am use

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL (Chief Executive Orticor or Lanally Ruponslble Instltutlonsl offlclal)

SIGN I DATE SIGNED

FOWI APPRWEO OUB h0 0 5 7 9 0 0 s

APHI 1 -HEADQUARTERS (A

UNITE0 STATES DEPARTMENT OF AGRICULTURE ANIMAL AND FlANT HEALTH INSPECTION SERVICE

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL IChlef Ex.cutlve OIRmr or Laaalk Rmwnslble l~ t i tu t i~nal offlclal) 1

I. REGUTRITDN NO. CUSTOMER NO. 936-0153 1154 FORM APPROMO


.

SIGN I DATE SlGhEO

OMB NO. 05790036 I 2. HEAWUARTERS wswcn FACILITY (Nam and^ r. as mgmmdwlh USDP.

@dl& zp cdi) GIBBON &&S&VZU~" L: d c m w P.O. BOX 800249 lu &\E.1F SANTA CLARITA. CA 01380 C ~*,q (L & (681) 286-2737

I. REPORTING FACILIN ILislall imt ima vrhsn anlmir mn hourad a urad in a m rearm. l&ng. teaming. wsrwnmmUtim, ar held lor mesa plmorer. AtOrtl sdditim*l sheets if n-w.)

FAClLm [email protected] See Altached Listing

TO 8 rsp5n IS r.gu,red oy la* ( 7 usc 2143) ~..t.rc 10 npor accm no 10 me rwlalons o n %am- SO# lor (err t m an won to -ass ard a n 11 an0 to 0s rd*a lo pna I a. as pmnad lor n Srtm 2150 YM! w .nt-Lon OILVI.DOAAh

I IYWW but not pin. d i s m , or used lw such of pain-

WIDOW. Te(oNmo drunr.

,N#TEO STATES DEPARTMENT OF AGREULTLRE I. ~ I ~ R A l ~ No. CUSTOMCR NO. 85R-0159 1147 AhlMA. AND PUNT HEALTh INSPECTION SERVCE


TOTAL NO. OF ANIMALS

(COD. C +

OM5 NO 05190036 FORM WPROVED

I 1. HUWUARTEW RUiEbRCH FACILITY (Name M d A W n s S , as wSfWd *rlh USDA.

ndud..?@~oh) ORTHOPAEOIC HOSPITAL 24W SOUTH FLOWERSTREET LO5 ANGELES. CA 90037

*SSUR*NCE STATEMENTS

I) pm(esrionr11y a-baa shndardr w m i n p the -. 1 m m f m d use ofmml r , indudinga~omplrte u s danenhel~ snslwdc, and Vsnquillup d w , pow lo, dutinn. and tdlainp edual m a a m , te~chimg. sting. surpcw. w ~ m m ~ l l o n uac idl& by air m r c h fatillty.

1) Each prlnclpl lnvnilpaU,r has mmdsldemd dlemativssto painful m u m .

I

(Chid Ex.cu(iv* 0M-r or Logally R.rponmible IruUtuUorul oMclal1 Cdmty lhm ms a m s true, anact, and mmpks (I IJ S C Seaion 2143)

SIGNATURE OF C.E.O. OR INSnNTlONAL OFFICIAL I NAME 6 TITLE OF C.E.O. OR INSTINTICUAL OFFICIAL (Type or Print) I DATE SIGNED

I 10/7 EAWUARTERS

1 REPORTING FACILITY (bst ell loa lms mere m m l s w m h w u d or used in .chul nseam, Wng. (wmmp, mewnmabuon. or held Iw w -u ~ l tssh ddaoml rhes if naslusry ) I

FACILW LOCATIONS(ms) see Plnarhad I ,dl"" I . . . . . . .- -. - . .

Southern California Bight ( SeaWorld San Diego. CA

5. Cats

8. Guinea Pigs ,

7. Hamsters I 8. Rabbits I 9. Non-Human Primates

I I /

10. Sheep - 11 . Pigs

12. Other Farm Animals

I I I I

41 Ths albMlng ~bdnadan for thb rapearc+ hcllny Msawmprlde 8ufhonlyto ensure lha pmnnon ds6aqMta Wennary care and lo oversee the adequasyal othcr BMWS dan lml a l e and use

I CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL I

13. Other Animals

Florida manatee

Ki l ler whale

Weddell s e a l

(Chief Executive Ofllur or Legally R u p o ~ l b l e Institutional offldal) Dr,

Pnnf, DATE SIGNED

APHIS FORM 7023 l f w h s u vs FORM 18-21 ( ~ s ( 01, whlcn u & s e w ( N O 91)

PART 1 -HEADQUARTERS

b S S U W C E STATEMENTS

5

10

45

5

10

45

4) manerm~ng wmnsmn mtnia rebasrm istilily hm sppmpns~ summh lo a a r m VN, pmvlrim dadoqwts ntmnmrymnm4 l o o m lm adsqueqof ema d anlml mre and use

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL IChlef Exocutlve Officer or Leaallv R@swnsible Instltutlonal official)

Harbor seal

N. elephant seal

a1 lhe above #s mnr. &:SIX &nplets(7 u s C SkPon 2143) pe or PnnlJ DATE SIGNED

APHIS FORM 7023A (Ropksn Vs FORM 1843 loct MI, wMch IS o b s w PART 1 -HEADQUARTERS

(AUG 91)

20

2600 .I //

20

:hnn

UNITED STATES DEPARTMENT OF AGRICULTURE I. IIECIaTMmW NO. CUSTOYII W. ANiMUIVO R*NT HEALTH IWPECTYIN SERMCE 93-R0185 1144 FORM APRIOMD om NO. 0s- I

I SAN DIEGO. CA 92037 I

ANNUAL REPORT OF RESEARCH FACILITY ( V P E OR PRINT)

I 3. REPORTWO FACILITY (Us1 ail l o u t i m man mnimais won h d or wad in a w l msemrc!. laling, t u i n p , M -maomlton, a hdd iwm+sa pu-. rn Mdiim.1

s h e if lucarsay.) I FACiLiN L O C A n O W ( ~

THE BURNHAM INSTITUTE SAN DIEGO. CA 92037

I. HUWUbRTERS RESURCH FACILITI (Name and A m p , er wirlaad Wh USD*. iMU* LO Cod.)

BURNMM INSTITUTE. THE 10901 NORTH TORREY PINES ROAD

ICIAL l T y p or PnnlI I DATE SKiNED

11105120(13

APHIS FORM 7023 (Rwlm M FORY l e13 (CWI a), W N C ~ b a l a t a PART 1 -HEADQUARTERS (AUG 91)

UNITED STATES DEPARTMENT OF AGREULNRE ANIMAL AND PUNT HEALTH INSPECTION SERVICE

I (650) 2252837 3. REPORTING FACILITV Wl *I l ~ m s u h a r e anlmls were MUM w u M in iCt~b1 maM. tabnu. lemlnu. w upnmnlstom. w M d IN t h puwra. AID& add~lloml

r n a u 11 n-ry )

FACILITV L0CATK)NWnhs)

See Anached Listing

I. REGISTPATION NO. C W E R NO. 93-Role3 1138 FORM APPROVED


OMB NO. 05740038 I I

2. H E I W M I E R . 3 RESEARCH FAClLlW W m s andAMns9, asr wislersd *m USDA. mduds m caw

GENENTECH. INC. 1 DNA WAY SAN FWWCISCO. CA 94080

4. Dogs

5. Cats

6. Guinea Pins

7 Hamsters I 8 Rabb~ts

1 1 pigs I

?h


30

I

CERTIFICATION BY HEAOQUARTERS RESEARCH FACILITY OFFICIAL (Chief Executive Or(lur or Legally Responsible Institutional official)

I caltitfthat lhasbave Is hue. wrmct, and W m p M (7 U.S.C. S&ion 2143) SIG I DATE SIGNED

1

10. SheeD I I 12. W r Farm Animals

AP IF41hcu M FORM IMt (03 w). IrNSh I. PART 1 HEADQUARTERS (AUG 91)

3 7

373

294

I

J

NOV 1 3 2003

373

324

I I I I I

I 2. HUWUrnTERII RESEARCH FlClUTY ( m a n d - , as mL.nd*M USDA.

ANNUAL REPORT OF RESEARCH FACILITY hchra z*r c o a ~ ( W E OR PRINT) NORTWIEW PACIFIC LABORATORIES, INC.

551 LlNUS PAULING DRIVE HERCULES. CA 84547

DATE SIGNED

/./.7kr 1 - H E ~ D ~ u A ~ T E R P


12. Oiher Farm Animals

I 2. HEADWIRTrRI RESE*RCH Fff i lLm (Namead A ~ r r . as npul.ndMh USm.

hduh, ZiD Code) YOUNG VETERINARY RESEARCH 7243 EAST AVENUE TURLOCK, CA 95380 (208) 632-1818


10. Sheep

41 Theanending vslananan fw this research kdlity has a m t i a t e auihe.liy to nrun Ua pmvlsim of .dsqme vstennsryrsra and t o o m a s i k o d q u r q of other aspeetr of snirml cam and uw.

CERTIFICATION BY HEAWUARTERS RESEARCH FACILITY OFFICIAL I

1. REPCillING FACILITY (Lial ail lawbonr Ma. andr m m hauled a us% in law1 mearch, latiq, leaching, m apnmnbtim, a M d fix mew pu-s. Altam aWihmal sheets it na-ry.)

FACILIT* LOC*TDNblN.r]

See Attached Listing

I

I DATE SIGNED

I 2. HE*WU*RTEW RESURCH FICIUT* (Name and A d d m as npwemd vlh USDI.

ANNUAL REPORT OF RESEARCH FACILITY ndud* 4 oh) -.

(TYPE OR PRINT) BIOSURG 279% STATE HWY 128 WINTERS. CA 85684 (018) 7852358

2) Each pnnnpal invertipalor has mnwdaed altamsiivas to plnful procedunn.

(Ch~ef Executive OfRcmr or Lmgally Responsible lnstnutlonal official) I cmblymsl the above o me, mnsct and mmpleu, (7 U S C S m o n 2143)

PnnlJ I DATE SIGNED

ANNUAL REPORT OF RESEARCH FACUT' (TYPE OR PRIM )

. .

UNfTED STATES DEPARTMENT OF AGRICULTURE 1. REGISTRATION NO. CUSTOYER NO. ANIMAL AND PUNT HEALTH INSPECTION SERVICE 83-R4211 1136 FORM APPROMO

OM0 NO. OSTgMI26

I (530) W d l W I. REPORTING FACILITY (Llrt #I lbat8onr *em ammls mwsed w used edn r d w l wd, laling. lesdunQ. or W m f m m , w M d formsss purmes Anrch sddnb-1

sheets l -..sv )

FACIUW L0CATK)NSIsXesl

ANNUAL REPORT OF RESEARCH FACILITY (P/PE OR PRINn

4. Dogs

5. Cats

6. Guinea Pias

2. HwWRIERS RESEIRCH FACILnY lNamandAddre6.1. as wlr (ed m USm,

MduhqpCdJ APHTON CORPORATION P. 0. BOX 1048 WOODLAND. CA 85778

7. Hamsters I I 8. Rabbits

I I I I I

13. Other Animals I I

11Pigs


I1 The mendins veterinarian for mls -rCh m l W has smpnnte aulhcnw l o cnrvrs me provlrion ofadquste rrtstinsry can and 0 o- me sdquasy of ~ r r aspar of animl a r e and use.

I CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL 1

8. No-Human Primates

0 I 4

-

- . - - (Chl.1 Ex.cutlv. OffIar or Legally ~ a k f i l b l e lnrtitutlonal oRiclal)

I mnihl that Uw, a h is we mmcf and mmpmls (7 U S C Skhon 2143) P ~ ~ I J I DATE SIGNED

4

/25/03 A iR.pla- F O ~ 38.23 (Oct II PART 1 - HEPSQUARTERS

(AUG 91)

ANNUAL REPORT OF RESEARCH FACIUrV (TYPE OR PRIW

I t ~ r ~ ~ ~ ~ ~ l l ~ - ~ * n r n t * d d ~ . t ~ m ~ ~ o *

-zbCobl O N I O N ~ T K Y l 4 ! ! a K Y I T O ( ~ ~ C A ~ (51O)Wd7%0

~ l ~ m ~ ~ ~ r I C L I P I ( ~ . ~ ~ a * * n n H - ~ w ~ d b . ~ u ) n w . r h W q - w ~ w W b h Y ) I . D w . ~ . d d l o r u l mr**nau* . l

? r s u l r L O U r m ( ~ Sr-UnO I

bnd. SMdiUme3. zx Wd lor use in tuching, w n g , srpsrimena, IIe. OT

TOTN NO. OF A N I W

(c0h.C. D+EI 1

(d 91)

PART 1 - HEADQUARTERS

Th8s repon is rsqv8rW by i au (7 USC 2143). Failure to repm ocmmmg lo me rqutauons can see reverse ~ d . lor I ~ D R O ~ S Y Reem ConVd NO result in an o r d a t o cease and dsrlrt and to oa s u a w t o p e n r l u a as pmvldad lor lo seam 21M. add~tma l infwmsoon. 0180-WA-AN

I 3. REPORTING FACIUTI lList all iocal8ms u 0 a c mmau w. house6 w wed m aaual research. I-nng, tlachtnp. w W m r r * n M o n or held iw thesa pumosn M a c h aadtuonai

*eels 8i " e m s s q 1

FACILITY LOCATlQW(shsJ

SAN JOAQUIN VALLEY COLLEGE FRESNO, CA 93710

UNITED STATES OEPARTMEM OF AGRICULTURE ANIMAL AND P U N T HEALTH INSPECTION SERVICE

ANNUAL REPORT OF RESEARCH FACILITY ( W E OR PRINT)

8y me Animal conat iond or Wellare R~UIIUO~S I H M a b I U M i n

1. REGISTRATION YO. CUSTOMER NO. 93-R0232 1132 FORM AWROVEO OH8 NO. 05790036

I 2. HELSOUARTERS RESEARCH FACILITY (Name and AMess, as regmwed w#h USOA.

, w a s zq coas) SAN JOAQUIN VALLEY COLLEGE 8400 W. MINERAL KING AVE VISALIA. CA 93291

TOTAL NO. OF ANiUALS

4. Dogs

5. cals

6. Gumea Pigs

7. H a m s t e n

8. Rabbits

2

11.P'ir

1

I

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL (Chief Ex.cut iw Officer or Legally Responsible lnstltutlonal omcial)

I cerMVfha l lhe above is he . conact. and wrnplsta(7 U.S.C. Swtkn 2143)

13

34

.

?

12. 0 t h Fann Animals

SIGNATURE OF C.E.O. OR INSTITUTIONAL OFFICIAL

13

34

2

APHIS FORM 7023 I R w i a s n VS FORM 1 u 3 (Oct 00L whkh b c4lo1ue PART 1 - HEADQUARTERS (AUG 91)

NAME 6 TITLE OF C.E.O. OR INSTITUTIONAL OFFICIAL (Type wPrint)

DATE SiGNED

11H8/2W3

CERTIFICATION BY HEMQUARTERS RESEARCH FAClUTY OFFlCUL (Chlef Ex.cutlvo Ommr or Logally Ruponmible InetIMlorul 0fflci.l)

I c d f y h l t the a b m is W. onset and u r m ~ (l U.S.C. SaXbn 2143) SIGN I DATE M N E D

ANNUAL REPORT OF RESEARCH FACIUrY ( N P E OR PRIKT)

1. H-M RESEARCH FICILIPI (Nan, n d A d d u * urlh USDA. nanaazb C O ~ J

TANABE RESEARCH LABORATORIES, USA. INC. 4540 TOWNE CENTRE COURT


9. Non-Human Primatas I

I 2. M%muMEu nE8EARQI FACIUTI (Nam am A w r a r . .* m irm USD*. M m c w

AMGEN ONE ANEN CENTER DRNE THOUSAND MKS. CA 91320

5. cats

8. Guines Plos

13. Other Animals

2

11. Pips

I f 12 -

PART 1 HEADQUARTERS

I

4

12 Omet Farm Animals 1 I

6

APHIS Form 7023 Site List

The following sites have been reported by the facility.

Registration Number: 93-R-0251 Customer Number: 1128 Facility: . . . . . - - . .

ONE AMGEN CENTER DRIVE THOUSAND OAKS, CA 91320

AMGEN ONE AMGEN CENTER DRIVE THOUSAND OAKS, CA 91320

AMGEN 51 UNIVERSITY STREET SEATTLE, WA 98101

N o t e no r e g u l a t e d s p e c i e s u s a g e o r h o u s i n g o c c u r r e d a t t h e S e a t t l e s i t e .

This r a w is r€qu?md by 11 17 USC 2143). Failure 10 npM .carding lo ma mgul8bmr a Sa m r a s side fa I/&/

h-RewiCmdrdM' nruit tn an orderlo cease and dda t and lo b. lubW lo pa1li .r .r p w d d lor in W o n 2150. addNonll inlomtim. 0 1 8 0 - W A 4 N

UNITED STATES DEPARTMENT OF ADRICULNRE I. REGISTR4TDN NO. CUSTOYR NO. ANIMU AND PUNT HEALTH INSPECTKW SERVICE 93-R0252 1127 FMIM APPROMD

O W NO. 05790036 I

T O T N NO. OF UllMNS

(ca. c + DIE)

5. cats I 6. Guinea PUP I

OCT 2 4 2003

APHIS Form 7023 Slta Us1


Reaistration Number: 93-R-0252 customer Number: 1127 Facility: 3AbE B€/t&d$+ ,

.- D A O E - ~ ~ E H R I ~ ~ m I ~ t t l - 821 LIMEKILN HOLLISTER. CA 95023

GCT 2 3 MG3

UNITED STATES DEPARTUENTOFAGRICULNRE ANIMAL AND PLANT HEALTH INSPECTKYY SERVCE

I Peninsula Laboratories. Inc. ANNUAL REPORT OF RESEARCH FACILITY 305 Old County Road

( ~ P E OR PRINT ) San Carlos. CA 84070

ME 8 K j W / - Z & - ~

1 AUG Dl )

ANNUAL REPORT OF RESEARCH FACILITY I I . H U D W M T E R S RESEbRCH F I U U n (Nam andAW.W u W *m USDA heM. Lp CohJ

(TYPE OR PRINT) B M A N . L L C P. 0. BOX 3752


1 2. HU.WUARl'EnI EsEbRcH rmuw ( N u m r n A W r u . .rngu*.b m OSO*.

ndudr Z I ~ coa) SCANTIBOMES UBORATORIES. INC. 8338 A B R A W WAY SANTEE. CA 02071


I 2. HEIWUUTERS RESEARCU FAClUTI (Nam9MdAdUWS. Btrag&Wed Wl U S M ,

nclude zp code) DMGNOSTIC PRODUCTS CORPORATION 57W WEST gSM STREET LOS ANGUES. CA SW45

4. Daps

1 12. Otkr Farm Animals 1 I I I I

I 6. Guinea Pigs

7. Hamswm

8. Rabbits

9. Nan-Human Primates

5. Cats

NOV 2 6 2003 -1

1%

CERTlFlCATlON BY HEADQUCRTERS RESURCH FACILITY OFFICIAL (Chief Exuutlva meor or Legally R~aponslbla I n ~ u t i o n a l omclal)

211

APH I R W U U VS FORM 18.11ION U), *hW L. ab.o*(. (AUG 91)

PART 1 - HEADQUMTERS

nf)

DATE SIGNED

' L y G l

n,s rRpn ir required by law (7 uSC 2143). Failure 10 r w n acmding lo the rqu la l imr sul SH lNChed mrm lor I n t m m c y R e ~ ~ 4 CMlrd Na:

esvll LO sn wder to caau, and 6eWI and l o be %bed D -1I1es as w i d & 10. in W i m 21! adoilimal inl-tim. O1BDWA-AN

UNITED STATES OEPARTMENT OF AGRICULTURE 7. CERTIFICATE NUMBER: 93.R-0272 I FORM AFPROVED

ANIMAL AND PLANT HEPiLTH INSPECTION SERVICE OMB NO. 057DWS cusTOMER NUM6ER: 1122

FACILITY LOCATIONS (Y tg 1 - S . e A t . d W L W g

ANNUAL REPORT OF RESEARCH FAClLlN ( N P E OR PRINT )

Heart InsUtute Research Fac. Hospital Of The Good Samaritan 1225 Wilshire Blvd. Attn: Dr. Kloner Los Angeles. CA 9001 7

Telephone: (213) -977-4040

I I I I I 13. Other Animals

I I I I I

1 ASSURANCE STATEYENTIS 1

DATE SIGNED

A

*heats If nuarmy or use APHIS Form 70UA)

E. Numwdarvns l r u p o n u h i d l W n D umimerto. resewch. w r m 0. D M m cmexlea InMluing lcmmpnyinp p i n w d k b la I h e M i d s and lo(

s l i r t l V. ul. 01appOpUIe .narhIk mml~Wc or tnnpullldm dws *auld b w c d n ~ d y a m a e d h a pmsdunr, w l b , w in tapaaum d n a weadunp. research. qminmU, w r w . or IssU I ivl e@sruUon dIM -duns pmdusing p i n or 4Islress In h e M(mb m d Ihe r- WCh nUOl ware not mad m s t w slucnea to lhir npat I.

REPORT OF ANIMALS

A

h l m b Cmmd 8, Tba *n:srl

w.mn R.gulrtloN

4. Dogs

5. Cats

6. Guinea Pigs

7. Hamsters

8. Rabbits

9. Non-human Primates

10. Sheep

1 1 Pi6

12. Olher Farm Animals

F. . . ~.

TOT& NU- OF ANIMALS

( COLUMNS C + 0 + E )

. .

107

CONTROL OF RESEARCH

C. N v n b r d aninsls u r n uhid? leaching. research mFfnmk 0. I& w e -dud& iwdvlng no &. dismal ll use d pain. rdieying dwp.

USED BY OR UNDER

6. Nmtwd animals be iw bnd. mdiuond . or W W w C M leaching. WSIIW. W m b . r-rch. DT n n w bui no1 wl us4 lo sudl O u m .

FAClLlN ( AnKh addlllonrl

D. N u n b r asrvmdr won *him w m n b , I m ~ w . -. . u m u y , w h b m cm4udM 1nvDlvlt.l acmnpmlnp p i n lu #stem la ha m l m i s .nd W W c h appopriate m ~ c m.lpais, w Mnqui lUw drum mn uwd.

107

This wn is nquimd by law (7 USC 2143). Faiivn to w m asmbing lotk. npulaionr un SumeneIH*for InW- R W CooM No rsrull in an uao, lo ca l ls and aair l a d lo b. wbpa lo m n i e s u p w b in SICtlm 2150. .dditiml intornubon. 01IK)-WA-AN

I (858) 587-2770 I 3. TORWIG F A C l F fU~t* l i lmlioru w n a n l d s m houud w w d In ml*M, Utlng. m i - , w mmnUWn, w Wdtor- P~POU. M .ddikma

UNITED STATES DEPARTMM OF AGRICULTURE ANIUILAND PUNT HEALTH INSPECTION SERVICE


4. DOgg I I I 5. Cats

1. -mN IIO. CIJSTWUL NU. 83-R0278 I l l 8 FORII APPROVE0

I 2 l U % C W b R l € R I R ~ C H FlClLlW 1 N W M m . sSnpllllrsd'&h USBA.

ircludszp C W METABASIS THEPAPEImCS. INC. 9390 TOWNE CENTRE DUNE SAN DIEGO. U 92121

1 12. O l k r Farm Animals I I I

O W NO. 0518QO38 I

1 13. OUmr Animals I

CERTIFICATION BY HEADQUARTERS RESEARCH FAClUTY OFFICIAL I w Wnf) DATE SIGNED

I

I PART 1 - HEADQUARTERS

( N O 01) / I/

NOV 12 200;

ANNUAL REPORT OF RESEARCH FACILITY 1. HE*WU*I IRIU R E M F A C W Warm . n d A d d . u , m U r n . m*lp -I

(TYPE OR PRINT) 855 ASH STREET

I (780) 7886650 3. R E M I T W O FAULIT* (U* all IDutiml wh.n mlmbwm hmsd musad in w nurm, trlnp. luming, nroo*,n*nlalm, orruldfuolmu wrpar. Amd, addiuaul

8- iln-Ury.1

rmLm U l C L r n l g l ~ Sm A M c M Lining

*dm* being bmd. mnditioned. or hMfuDTuUln b*ning, tatinp. w m a . ream,. or s u w y but n a YetuMdhraud, P"ID0.U.

~ ~

inMlVlnp no win, dim. or

u h l e h ~ m a t l . tslchlnp r u m . w * ~ . * t r b m ((ndud.e 1 n m w acawwMn9 wn u d i w m bU nimls ."a fu.Ai7M lF9mpll.W m*mao. arulwc m tmwlmng d m - uUd

TOT& NO. OF UllW

I APHIS V. FMUl1Wa Mb*h*h b 0 b . a ~ HEADQUbRlERS

m i l npwtis w u i m by I m ( 7 USC 2143). Failure Ion~r laUording Olhe rsgulationr can See meme side 101 lntaapency Repon Corlml Na result in anv.ewlo -a and deslat and lo be rubwl lo wnaltier sr proMdad for in S W m 2150. lldditional mformatim. 0180-OOA-AN

I (858) 587-8788 3. REPORllffi FACILITI (Ulit all l-lims vhen animls w m nourea *l cr in muai -mh. tmting. teaching. w expcnmnWon. w ndd fwmme purporn. Anach Wditimlll

sheets if n-ly.) 1 FACILiN LOCATK)NS(olerl

%e A M c M Llstinp


(Chlef Executiw Offi-r or Lwally Responrlble Institutlonal offlclal) I cartiylhattlm a t o w ts a.m. cwsct. and Compete (7 U S.C Sectcn 2143)

I DATE SIGNED

FORMAWROVED UNITED STATES DEPARTMENT OF AGRICULTURE

ANIMAL AND PUNT HE*LTH INSPECTION SERVICE

I 1. HUWUMTERS RES€ARCH FACILITY (Name and Addesr, a 3 W e W wlh USDA

rndud* zp Cam) LA JOLLA INST. FOR MOLECUUR MEDICINE 4570 EXECUTIVE DRIVE. STE t W SAN oimn C* Q Z ~

OM0 NO. 05790036 I 1. REGiMRATK)N K). CUSTWER WD. 83-R0288 1112

1 3 . a h A n w . - I / WE ONLY USE R9TS AND MICE

I 2. HUWUARTERS RESEARCH FACILITY (Nams a M A d d m , as regutma wM USDA.

ANNUAL REPORT OF RESEARCH FACILITY mude lp codel

(TYPE OR PRINT) ANIMAL PHARM SERVICES, INC. 303 DRY CREEK ROAD

mir npen is reguitsd by law (7 USC 2143). Failure to rewn amording lo the rqulatims cm Sw rawme side b r Inlarageno, R W Conld No ' 0 m u i l in an wdsr to -us and desist and to bs ruWo psnaltia aa pmvidad fw in W o n 21Y). additional infwrmlim. OtW-OOA-AN

HEALDSBURG. CA 95448 (707) 4310171

3. REPORnNG F A c l L m ( ~ i a ail t m i m s uhr. mimals wsm b e d or u r n in emal mssmh, tasting. !.aching, orsxpnmatatim, u held fwmere prmmss. At- dddonai shw if n-saw.)

FACILIN L O C A ~ N S ~ ~ S I

Sa, A M c M UsUw

UNITED STATES DEPARTMENT OF AGRICULTURE ANIMAL &ND PUNT HEALTH INSPECTION SERVICE

REPORT OF ANNULS USED 8 Y

A.

I . REGISTRATION WO. CUSTOMER W. 93-R0298 1108

FORM APPROVED OM0 NO. 05794038

'OR UNDER CONTROL

m i M I S Wing

Condibwad. w h i d for use in tsadlmnp. testing, wer immu. mearch. DT *urger/ but rd m u s e d forsuch

:RESEARCH FACtU

C. N u m o t adMIS UPM uhich leaching. research. eWlm(Ln6. W te lb - m d u a e d i naung IM pain. distrm, cr wu of pain-

- u o n m n a . mum. r,qw w isad- mbaw mr~v lng m p a n * n g pa n or a smrs to me an m m am form cn me s s otapormnals .wLhs(c aru ga.r or mnp.~ ung a r w *od a run a m h y .mtd me D?cewml ms. u DT n t ~ p w m m d ln lea67 ng m l c h u p n m n ~ s $ 4 ~ . or tru (A" sdammn 01 n pocswaa waucn) pen w asvsss n meae s m s l s s m m e m s n s wn ms nre mf vseo

TOTAL NO. OF ANINALS

2) Each pnwipal mvsrbpalw nar cmsldsrad allemlives lo painful pmcWunr

I ) TM aUeMlng Mtainmsn for this r-rch fkll i ly h u appmplau auVIEnly to maum me pmvl3im ol Wquale Wtinaw cars IM to 0-a !ha sdmsguacydMhar a a m of animal care and use.

I CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL IChief Executiw ORlmr or baallv Res~onslble Institutional offlciall 1

This repm is quire3 by law (7 USC 21431. Failure to repon acmdinp to the rsg*rldimr wn See~erw*ds fo r lnleragsncy Rwnt Cootrd NG ~ u l l in an ordst to solse and &sin and m be subject 10 p.naUw IS prondsa for in W i m 2150. add'Wm.1 inlMm.1Im. 0180-WA-AN

4) The amdinp ntetinatim for mia r e s e w n fasiliry has a w r ~ l l m aumotity lo msumth. pmvirim d ad+wle MMnnary wre and lo ovnrae the adsqvacy ot Mher aspects danimsl can, and use.


UNITED STATES DEPARTMENT OFAGRICULNRE ANItMLAND PUNT HEALTH INSPECTON SERVICE


(Chid Exacutive M c o r or Lagally Ruponaible inrtltutional Official) I wh, ma h e above is vua. c o r m , ana m p r u (7 U S C SecUon 2143)

SI I DATE SIGNED

I . R E G M I W N NO. CUSTOMER NO. 83-R-0314 8227 FORM WFUOVED

O W W. 05794036 I

'2. H U W U m R S RESEARCH FAClLKV (Name and AWresa esregrslwed *nlh USDA W u d e Zb Codel

U KJLLA INSTITUTE FOR ALLERGY AND IMMUN 10355 SCIENCE CENTER DRIVE SAN DIEGO. CA 92121 (858) 558-3500

APHIS FORM 7023 iRapl~.cnVs FORM ld23 (On Mhwhkh i. Wb PART 1 - HEADQUARTERS

I REWRTlffi FACILITY (Llrt all locltionswh~e anmalr w e h w u d or used in mual m.anh, BsUng. teashmg w e*Wnmmtatlm or held fo! m m p u p - c i m addltlmal (im if " w a r y 1

FACILilV LOCAWNSlWesl SBe Allache4 LSbng

(AUG 91)

lnlding, tsrtiw. leal8 w (cols. c r m m a n b . d u c t a d disM8 10 h e miMIS interp&Uon d lhs mchlng, meam. DIE) remsrch. or IIIMIVI~ M and fwwhlch appmptim s w m b , lu-, w Mu. (An explanatnn of r u m M n d pain, diatnnu. w anealhdc, analgsalc. w m e m ~ d ~ ~ p a i n O T ~ ~ B S B in these W u r M for such insofpain. tnnquliring dm* wn aMMIJ andmemasons %nd!t,qs w not used P u V . n(lMq d w l . &. mu# bs amhsd 0 w repon)

This repon s rewind by l w (7 USC 21431. Falure tor- W i n g lomo regulations mn S- -0 Sde fw intemgmcy m p m m t m m mvi i om ao rxda h, and dsrist and h, be s u W to pame @s W a r n lor in %im 2150. additional informatton. 0180001-AN

UNITED STATES DEPARTKNT OF AWIICULNRE ANIWAND PUM n w w INSPECTW SERVICE


5 Cats

6 Gu~nea Pups

7 Hamsters

8 Rabbts

3. REWRTIWO FACIUTI (Lmt all locations Hhsra mimais m e housed w wed in actual m a r s h . 1-tinp. leaching. w sxpenmautim. w hsldfwmee pum- Attam addlbonal w, of n-lly)

FACILITY LLOWMNS(mJ See Attached Listing

1. RCGISTRAT10N W. CUSTOYR NO. 83-R-0323 8225

9. NonHuman Primates

10. Sheap

11. pigs

12. OVrr Farm Animals

4) me anaairm Metinanan far ms research faciliv hlr appmpnateaumwilylo mrure the pmvlvm d adapuab mtatimly un and m ow- the adequacy 01 other ~SPOEO 01 animal care and use.

I CERTlFlCATlON BY HEADQUARTERS R E S W C H FACILITY OFFICIAL 1Chlef Executive OIAcer or Lenallv Reswnslble Institutional offlciall I

FORM APPROVED OMBNO. 0518mJ6

0 0

0

0

13. Other Animals

.

. S I I DATE SIGNED

1. H U W U M E R S RE8EmCH FACILITY (Name sndlddsss esre@swed Mfh uSDA, Mubs 263 Coae)

PRESIDENT 8 BOARD OF TRUSTEES OF SANTA CLARA COL. 5W EL CAMINO REAL SANTA CLARA. CA 95053 (498) 554-4100

0 0 0

0

0 0

0 0

0

0

0

0

0

0

0

0 0

0

11/24/0

0

0

0

0

AP (RWWM FM~M lk11 ~ ) . w m h b ob.ol.a PART 1 - HEADQUARTERS (AUG 91)

- - -

0

0

0

0

0

- - --

0

0

0

0 - 0

0

0

0

0

0

0

0

0 0

mi) rapon is requ~rea by taw 17 use 21431 Failure 10 repon according to me rqvtatlms can see nvnre stat yy' '? IM~~ lpency Repon Conlrd No ~ u l t in an order to se-e and deist and to a t aubwt to psnalaes as provided for in W i m 2150. sdditimai mfmation. O~~O-WA-AN

I ,. .-,- "" "-, 3. REPORTING FACILITY (List ail locdt~ons wnwe mimsis wsrr h u e d or used in anual resemrbl, tssbng. teaching, or expsnmsnlation. or held for mere pumores Atmm a d d l t i o ~ l

shes if "ecel..ry.I I

UNITED STATES DEPARTWNT OF AGRICULTURE ANIUAL AND PUNT HEUTH INSPECTION SERVICE


FACILW WCAT*IK)(s#es)


I . REGLTRATION W . CUSTOYER NO. 93-R0326 1102 FORM APP OVED

OM0 NO 05790036 I

a. HEADOUIRTEFS RESEARCH FACILm (Name and Ad&ers as rrgslersa w ~ h USDn ioclude zp C O ~ S J

BIO-DEVICES LABORATORIES 2116 W COLLINS AVENUE ORANGE. CA 82887 ,,,*,R?O.0W,

15. cats I

REPORT OF AMMALS USED BY OR UNDER CONTROL

A.

Anm ls Cwsrad By TheAniml

Welfare Rsguletimr

4. Dogs

6. Guinea Pigs

7. Hamsters

8, nYmbwot mmal r b m g bred conditioned, or held for use m te.ching, laslmp. srpaimanrr. mearch. a surger, m t "of yet mea for such pulp-,.

RESEARCH FACILITY [Aiisch addlorn1 sheets imauwywuSe APHIS FORM 702% 1

1 8. Rabbits

C. Number of animls upon Mrch teaming, research. awrimanrr, w U L I ~ w e c ~ d u n e d inwlving no win, d i r m r . w use dpain- retlafng drugs.

1 9. Non-Human Primates I

I

13. Ciher Animals

F.

TOTAL NO. OF ANiMLS

(cob. c D + El

D. NumbOrdan i~ I s u r n vhich e.panmml8. tcschinp, resear&. surger,, w ta ts u a s mnductod mvdving acumpanvmg p n or dd lms to me mimals and for whim ap&lle mamatic. amlg+@c. w ~ m q ~ l l i z i n g drugs uns wed.

1l .Pips

12. Ciher Farm Animals

2) Each pnnsip3 invastigatw har unaidsrsd Mtmmvo. b minful p r d u n .

E. Number d animalr upm vhim teaming. srpetimnls, -mh, avrgayor tssta wwa conduned inmlvinp accompmylnp pam or d w e r r m the animal* ma forwhim me use d approptiale B M l ~ d i c . a ~ ~ l ~ F l I ~ . w Vanwl idw drugs would M- advemy a w e d ms pmcodura. resub. or inMpnWlm dm. teming. mearch. sxpaimarr, surgery, am. [An explanafbn of ~ p m c e v ~ n s p m d u c l o g p s i n or mwess m msse anmafs andm resons such bugs were MI used mwf b. s m h d m thh m p ~ I

/ P

11 n s lac b r wnvlnp +c me runa*ms ma ,q.lmw ~naerlru *n in0 n ha8 w. re.5 mat u c w t m s to me sramams and r q u soon8 os swhw m a sri: amea oy t rc ennclpa n-tgmor ma ~DPIOM by ma msufyt ma MO~MI C.m am JU Cemm nee IACJC, A u- d .I# m m u p ~ o n I. ~ u l * d to mi, annu.1 -n n ma !.on lo denl*Pw !he * C u C - . ~ m m w o n % Vl s su-ry nodo. I on* mmmm dm emdtons n r as me 8c.ao.1 am n ~ m o r d an ma s an-

NOV 1 7 L/

41 The mandlng VMmMnsn for th!r rerearch fac818ly has appm(riate avnDIlty lo anrun me pmnrim d.d.quate Mtnnary u r e and to owsee tho adeguasydemor aswas d mlml care and use

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL (Chief Executive Officer or Legally Responsible Institutional omclal)

DATE SIGNED

1 [//0/63 (~.p.sVvs FORM 10.23 (Dst MI, whbh ir 0DwI.h PART 1 - HEADQUARTERS

(AUG 91)

13. Other Animals

USIJRIIICC STATUlEKIS

1) Pm(BUlmaiIy~~~e@abIe rundams g o w i n g me cara, t m m t . Md use d mimals. inclwling sppropnlt. me d anasmebc analgesic. and Vanquiiiring d ~ g s , ptiot 10. dung, and following r t w l meah, Isacnlrbg, testing, surgery, a ~ m n t l t c n uas folla*sd by mi8 w a r m fri l ihl.

FORM APPROVED UNITED SlATESOEPARIMENl OF AGRCLLT~RE ANIUAL Ah0 PLANT r(€A.lH IhSPECTlON SERV CE


OM8 NO 05790036 I I. REGISTRATON No. CUSTOYR U). 93-R-0333 1098

I 2. nEMWARTERS RESEARCH F A C i m (Name andAdbesr, asrsg&lwed n t h USDA.

muds zg cow FERTILITY INST. OF CALIF.. THE 1515YGNAClOVALLEY RD. STE L WALNUT CREEK. CA 94598 (925) 9461828

1. REPORTING FACILITY (List all i d l m s uhaeanMIs was hlursd or u u d in ulud r-rch. Inling, tlachng, o r a ~ m a r t l t i m , or Mld f w t h m p u w e Mach aadltimal ,heel, if n-rary,)

FACIUTI L O C A T D N S ( ~ I


4) ~ h s anmdng wtananan for mls mrsarsh kcll8ty ha8 appmpnate aummb'to nrurs me pmnsm dadaquala vatennary u r e md lo 0- the .d.auac~ of Mhsr r+ped. ofanmai cam and use

RESEARCH FACILITY OFFICIAL (Chlef Ex.cutlw Officer or Lqally Responsible Instltu(lona1 olRdal)

complete (7 U S C SecWln 2143) )

DATE SIGNED

qq.3 ART 1 - HEADQUARTERS .

mis reW l i w u i d by law (7 USC 2443). Failure 10 npM acmrdng lo me npuiauonr u n S48 r e m s side lm muit ir. m arda 10 mass and aarirt and to be sub* lo wIII1im as p m u w lor in senion 2150. sddibmal inhmmm.

W;yEirAvm contml M

UNITE0 STATES DEPARTMENT OF AGRICULTURE t. REGIWRATYIN NO. CUSTOMER NO. ANlhUL AND PLANT HEALTH INSPECTION SERViCE 95R-0339 1236 FORM *PPROMD

OMB NO. 05180036 1 . - --- . . - - . - - - -. . . FOEITANA. CA 32335 (903) 8751018

3. REP- FACILITY (Llsl all IocaUms when aNMlr m h d ar used in mu81 -nn. tntmp. lMhing. w axpsnnwntetion, or held fw IMIe p u r p o ~ ~ . Anach additimal shee6 if nksrrav.)

FACILITY LOWTK)NS(&esI See Attached Listing


I 2. H € M R U M R S RESEARCH FAClLm (Name andAms.% asrsgmlsrsdm USDA,

mudo zp cow SURGICAL SIMULATION TRAINING CENTER lffi75 Nl lFV l l COLIRT

41 The amdm9 Wmnanm fw tho= w e m h f.olity h a appmpnate authority to a rum ha gmvstm dadeqme mennary a m .MI to O- theadwwsy dothw avms 01 .",MI care and us0

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL (Chief ExecuUw Offlwr or Legally Respomible lnstiutional official)

S1

yp or PmIJ

DATE SIGNED

11 /07/0? APHIS FORM 7023 I R - l u M FORM 16-23 (Oct II), which b ob.om. PART 1 - HEADQUARTERS

( N O 91)

I (949) 7-30 3 REPCNNC F A C W WI #I IoCltim- m l M l s w m h w M w w a o m aau* march tarbc-a Lsad,mw w ewdmnmon. w hda for ma. pupx- Anash adammi

M n - u w ) FACIUT* LOCA7KHB(aP.d)

See Amchec Listing


CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL (Chlef Executive Olfiar or Legally Reswnslble InstlMlonal official) I

I 2. HE*WUARTERS RESEARCH F A C I m (Name andAddebs, as r e g a m with USDA.

hdude zp CWeJ COASTAL FERTILIM CENTER 49W BARRANCA PARKWAY. STE 103 IRVINE. CA 92604

'

DATE SIGNED

- ERS

12. OWI Farm Animals

13.O(her Animals

41 The anendlng Wsrlnarian falhls r-nh f.clllW hM s m d l t * l W I y lo msue ih. pmvlrlm d adequate W a i n a r y a r s and loawnsa the adsquacyd M e r smcm d mimi cam and urs

I CERTIFICATION BY H WOUARTERS RESE4RCH FACILITY OFFICIAL (Chlef Executiw Ofticor or Leaally Responsible Institutional omclal) I

ntJ

1112010

APHIS (A

NOV 2 5 20W

Interagency Repat C m t d No 0180-WA-AN

UNITED STATES DEPARTWENT OF AGRICJLTLRE I. REGmRATDNWO CUITOUER NO. ANIW ANDPtANT HEALT~ iNSPECIlON SERVICE 93474361 1270

FORM AWWVED OM8 NO 057sW36

4) The at tadig wleAnari.nfwmis mrearch fadlity b a awmptiale aumority lo aaum the pmNrim dMaqua@ v m n a r y u r e and lo ousna, the adsquacy d dha a m ol ln im canma urn.

CERTIFICAlION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL (Chief Executive Ofticor or Leoally Responsible lnsthutional official)

v ' ANNUAL REPORT OF RESEARCH FACILITY IJL" (TYPE OR PRINT)

I Csrt'i that lk above is tnr , cokt;acd &mpl&e (7 U.S.C. Ssslkm 2143) DATE SIGNED

I 2. HUWUISI IERS RESEARCH FACIUTY (Name and AWm. ssrwIJIwsd w#h USDA.

ioclunt zp code^ PMRMACYCLICS 995 E. ARQUES AVENUE SUNNWALE. CA 940.96 (408) 774-0330

1 I A (Replao- M F O W 1W3 (Ocl EADQUARTERS

( N O 91)

1. REPORTING FACHIT* (Us! all locaimr uhara snimals w~ hausad w used in Mrul research testing. leaching, or experimontmm, w lwld fw h-e puwes . Amch addttional .heels if necassary 1

FACILITY LOCATKINSl~sJ

See Anached Listins

. . - . .

i n s t i t u t e of C r i t i c a l Care Medicine

I


I 2. H E I W W E M RESEARCH FACIUT* (Name aMAadsss, as regwed USDA.

m~uds zp code) INSTITUTE OF CRITICAL CARE MEDICINE 1695 N. SUNRISE WAY PALM SPRINGS CA 92282 V 760-778-4911

^ rr ~ r u t t ) I DATE SIGNED

I 3. REPORTING FACIUT* (Ltat UI l o u t i m whem mimls uw h a d or usad in M01.I w r c h , tatinp, teaching. orsxpaimhtion, or hatd for tJwa pu-. A M additi

10. shssp

11. pi01

12. Mher Farm Animals

13. Omer Animals

PART 1 - HEADQUARTERS

99 99

m8r w o n IS raqu8red by law (7 usc 2143) Failure to rap^ r o x a n g loth. rsguiat~ms u n See , e w e (lode tw ntmgmcy Repon Ccntrm Un rswlt m an -lo m l e and dedat and Lo be subwl to penmes as pmvldW fw m S m o n 21% a d d ~ t ~ ~ l mfCrmattm T J 018000A-AN

4. Dags

5. Cats

UNITED STATES DEPARTMENT OF AGRiCULTURE A N I W AND PUM HEALTH INSPECTION SERVICE


1 6. Guinea Pbs I 1

1. REQIMRATION W CUSTOMER W. 93-R0383 1274 O W FORM NO WFUOMD C57579M36

I 2. HEIWUARTERS RE6EIRcn FACIUT* ( N B ~ a n a ~ w e s , aarsg~twed w?h USDA.

vlclude~p codel 8 L P 810 LAB SERVICES 1115 MARINEVIEW DRIVE VISTA, CA 92083 (760) 9413430

I

1. REWRTlffi FACIUn (UQ I louumr whas mi m e Mused w used in a w l m r m . &sling. 1 m i 4 , or u p t i m l a l i m , w M d for mne purpolar. Auach additlmal shmr it nasrsanl.) ~t A "r: (43

FACILm L O U W W l l ~ s l See Attschsd Llstinp

41 The anendmg marinanan fmm8r maarch hal ib ha appqnate aumml b mumtho pmv~slon of Idequaw vaannary un and 10 OM- the adequacy of omer aspects of lnlnvll a r e and me

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL (Chief Executive Officer or Legally Responsible Indltutlonal offlclal)

-

DATE SIGNED

L\ 3 4

EADQUA~TERS

. .

4) me anend8np vctcnnsnnn for mls ~ssarshfadlity hasamwiate auhativ t o w n h e mi r ion dMsqwtr WHlnsryure md lo ow- me Msquaq o( dMr aspsar d m i m l care and uw.

I 1

UNITED STATES DEPARTMENT OF AGRICULTURE 1. REGISTRATKIN NO. CUSTOMER NO. ANIWL AND PUN7 HEALTH INSPECTION SERVICE 93-R43M 1278


SIGNAT t) 1 DATE SIGNED

FORM APPROVED

I 2. HELWUUFIEM REIEIRCn FICIUTV lNuno .nd*danr4 as rspolarsd wdh USOA

ndud. ~p -1 SIERRA 810 SOURCE. INC 280 COCHRANE CIRCLE, STE E MORGAN HILL. CA 95037 (408) 779-4533

OM6 NO. O57sM3B 1

3 REPORTING FAClUTV (LSt 1111 loc.Ums*rhl*(r lnlmlr w e n d w used In Mu l l rw rsh , lanng. m l w . W W4m@tim, U h.ld(or lhas VpCSMS A M sWlllmal rh-b 11 necessary)

FACIUTY LOCATKIWIl~os) See Attadled Llstlng

r I 80 c D,, ROJ ,dG;l-., CIS 350x0 J / u

mar npM is regu~red by law (7 USC 2143) Fallunlo r a p M scwdlnp lolho wlationr u n S a r e m e wde fu IntMpacy RspM Cmlrd No rarvlt in an wda to mars and dswrl and lo W w w lo pnnl lm as pmndd lw on W m 219 addlmal m l m l l o n 0180-M)*-AN

(Chl.1 Exrcutlvo 0ffIc.r or Legally Responsible lnstltutlonll official) I cemty ma1 Um smve IS he . mrect, and mmpste (7, S C Sectlon 2143)

SI MJ I DATE SIGNED

UNITED STATES OEPARTMENT OF AGRICULTURE 1. REOISTRAmN NO CWTODER NO. ANIMAL AND PLANT HEALTH INSPECTION SERVICE 83-Ram7 1298

ANNUAL REPORT OF RESEARCH FACILITY ( l W E OR PRINT)

FORM APPROVED

I 2. HE*WUIRTERS REEEIRCH FACILITY ( N a m t s n d M U . *I W W N W * m USDA.

wude ze code) APPLIED MOLECULAR EVOLUTION 3520 DUNHiLL STREET SAN DIEGO. CA 92121 (619) 5874880

OMS NO 05790038 I

1. REWRTINO F ~ L I T V (~1st LUI 1xa110nl WM aninsis were haasd w usem in sdw l raarch, testing. @aching, orr*pa imn~urn. w h d d b r mere p u w r Altach sddl~onal I M ~ o ne-v.)

FACILITY LoC*mNw.hrl

See Attached Listing I

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL (Chief Executive Omwr or Legally Reeponslble lnstitutionrl official)

I certil) that lhe above is he . cormcl, and mmplete (7 U.S.C. Setimn 2143) DATE SIGNED

///L /OJ APHIS FORM 7023 IR.placn VS FORM 18.23 (Oct MI, whlchls obsolU. PART I - HEMQUARTERS

Tn s r e m r nu, red by a" (7 uY: 2'63) Fswm lo r- amold ng m me r q . m onr a n See re- r a s l a .~langcncy R- m l r o No res.81 ?an aaer 10 CCIIL and asrrl m a lo o. I.+ m paa.bsr .I m d M lor m Smm 2153 &tw1 n m l m . 0180.WA.AN

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL (Chief Executlvo W w r w Lwallv Rwwnalble lnstnutional offlclall I

LhlTED SlATESDEPARTMENTOF AGRSLLTJRE ANIMAL ANDRANT HUTH IWECTION SERVICE


I cemty mat ma stmw is me. cor;sdana mrnpleto v u s c S e a m 21431 .

S UL (Typ. or Pml) I DATE SIGNED

I 2. HEIOOW.RTER.5 RESEIRCH FlClUTY 1NamsndAWmrr. as nplBwedwM U r n ,

bx ld4 zp C O h ) ENDOCRINE TECHNOLOGIES. INC. 35325 FIRCREST STREET NEWARK. CA 84580

I. RLOSlRAllON NO. CUSTOMER NO. 05R-9370 1WX)

FORM APPROKO OM8 NO 05790036

(b)(6), (b)(7)c

I LA HABRA. CA 80831 (562) 681-1 152

3. REMRTlNG FACILITY (Lisl all l xa t im t mas anlmls ware housed or used in lml resemh, at iog, lumrnp, or expnmnuum, w h*d l w hae w-s. Altach addrtirnal Sheds l wceSsary.1

FACILITY LOCATDW(Mes1

See Altadurd Listing

m ~ s npat is ragulnd by law (7 usc 2143) f a w e lo r m n sccordlng IO IM rspulstirnr can Sea r a w stde for Intawnsncy R e w Cmtrd No result in an order lo cease a d d w s l and I0 be sub@ IO pendues s~ pmndd fw in Sedion 2150 ~1 l lm . l tnf-tlm 0180COA-AN

I AIrndlS c w I m m uammg. I IUChnp. ,.urn. I TOTAL NO By The h.ml d m m w u 1-161. ylw ~ ~ a l s * c r e lo?mmrnls .m l c r m c h t n ~ u d l p p m n m OF bN1MA.s

watara RW. arms I noa for a. n I

UNITED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PUNT nwm INSPECTION SERVCE

ANNUAL REPORT OF RESEARCH FACILITY (PIPE OR P R I M )

7. Hamslers

8. Rabbils

9. NonHuman Primates

1. RMUlTRITlON NO CUSTOMER NO 83-R4371 1304

4. DOES

5. cats

8. Guinea Pigs

lo. sheep

11. Pigs

12. OtherFam Animals

FORM APPROVED OM0 NO M7PW36

I 13 Other An~mals I

I . H m U * R T W RESEARCH FACILITY (NsmemdAdaw. a r r e W H . d m U W ~ z & c o d . l

THE DOG LOOGE, INC 1551 W LAMBERT RD

70 80

(Chief Executive O(Rw or Legally Rnponslble lnstnutional omdal) mmly that the aboM .s true, mnen, and mmpble (7 U S C SSecloon 2143)

SIG I D A E SIGNED

70 80

I (858) 628-i& a. R E ~ N G FACILITY (List 31 1-umsmcre aMmla wen housed or "lad in xtstwl raasrrh. ImUnp. IpOUq. w ~ m n m l l o n , w hdd for 1b.e p u w s . Attom sdditionri

s w s if -v.) FACIUTY L O W T W s W

See Anached ListinQ


.. . - . .-. - .~ ~

Animals Covered bnd. mim lasmmg. ~pbl inp, -&: By The Animal m n d i u d , cr M ~ , IUW. 01 BMwn lorn animals and f w m i m me uw, 04 a m " t e OF ANIMALS

W e r e Repulatiow held fw v x in c w t i m n b , u mnductad inbdving amhe=l~.m.lWc. umuui i lunp d r u w w l d leaching, tesbnp, mu wfa ssmnpsnmg p i n or h s u e a d w d y a f i ~ a d !ha m u m rewlu. or (Cob. C + ~pmmnb. d u n @ d i m s lo the an1n-d~ intamrseticn d m e mchinp. m. D+E) nlasrm, w inmMng "0 md fwwhlch a m a e e m m u , rum, u tens. (An ewianaUx of S- but mt pain, dluresa, or anenhetic, malgauc. w V n p m G w M s ~ p . h wdirlmu h Ihssa ySIu8WfWSU61 usadpin- mnquillang drvprmn a-h aod!Aemroor subl @I *v. "04 used p u w s . w ~ l n p d r m Y W . m s t a a h ~ h . d e m @ m ~

I 2. H E I W W T E R S RESEARCH FACILITY (MOM andlddnrr. s.mfIwad w*h U r n .

n m zp c d e ~ THE NEUROSCIENCES INSTITUTE 10640 JOHN JAY HOPKINS DRIVE SAN OIEGO. CA 82121

5. Cats

6. Guinea Pigs

7. Hamsters

1 12. Other Farm Animals I I 1 I


10. Sheep

13. Other Animals -

41 me anendis ~lsnmnan f u tha reseam nnllty has appmpnak aumonty lo arum me p ~ v l r i m dsdsquats m r i n a l y -and lo -W me a d e u w d d h a B S P M 01 Bnlml an and USE

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL (Chief Executive officer or Legally Responsible institutional omcial)

DATE SIGNED

0

I I I APHIS FORM 7023 R.pb~es VS FORM 18-2s [Oet MI, uhkh I. obsonte PART 1

( N O 91)

0 0 0 0

bhl1EDSTATESDEPARTMENT OF AGRICULRRE ?. REGISTRITION NO. CUSTOYUI 110. ANIMAL ANDPUNT r(ULTH IhSPECT ON SERVCE 83-R0377 1331 FORM WPROVED

OMB NO 057-38

41 me atUndinp mlnrur im for mi3 f ~ l l n y has sppopnsbsvthmly i. ensum i h e p m i o n dsdsgusle metimly mm sod lo m- the dsquacy d m a s p a d anlmsl a m and use.

I CERTIFICATION BY H WQUARTERS RESEARCH FACILITY OFFICIAL I


(Chief Executive MAcer or Legally Responsible Inrtltutlonal offlelal) print) DATE SIGNED

APHIS FOR 1 q7h3

PART i . H WQUARTERS

u'-

I 2. HEAOOUARTERI RESEARCH FACILm (Mm sndAWRS, a s w M m d WlI USW,

in&& zo CM~) LIGAND PMRMACEUTICALS. INC. 10255 SCIENCE CENTER DRIVE SAN DIEGO. CA 82121 (858) 550-7888

J. REPORTINO FICIUW (LISI 811 ~oulums unananimlrmn hwsed or used In r w l -m, tntinp, teaching, a u p t i m a t . t i m , or M a fw m r w plwsa% Aitsch additimsi sheets if necessaly.1

F IWUn L0CATK)NWSW

See Abched Listing

\D&5 5 c i . f i o cen.\er\3~.

This rapai is rewind by law (7 USC 2113). Failure lorapaiaccdinpto 1hcnpUtlmscsn Sesrev-nWfm bmpcncy Repon MnM NO rexlll in an ordm 1o-x and dwin and u, bs rubmf 10 -Ilia as mudad fw In %lm 2150. aMIUcwl mf-Urn. 0180-all-AN

I SANTA CRUZ. CA 85M)O I


I (831) 45738(30 I. REPORTINO FAClLm (List all losafmr unae an~nrlr *re housed oar used in aaum r-rch, lal~ng, Ihdlng. o, opnmnbt im, w hold b r lhme plrpna. AHacn addil io~l

sheell if nearww.) FACIUTY LOWTIOHSlsX~sj

See Anached Listing

FORM APPROVED OMB NO. 0579-W36

UNITED STATES OEPIRTMENT OF AGRICULTURE lNlMAl AND PLANT HEALM INSPECTION SERVICE

2. HE*WWJITERS RESEARCH FACILITY mema^ ma^^^^ ar widend wm um. mu* Z@ ccw

SANTA CRUZ BIOTECHNOLOGY. INC. 2161 DELAWARE AVENUE

5. Cats

6. Guinea Pigs

7. Hamsters

I (. REGUTRANON NO. CUSTOYUl YO. 83-R0380 1%4

1 8. Rabbits 1 0 I = I I 1 8 2


10. Sheep

1 12. Mher Fann Animals I I I I I

. .- .. - . . .. .. . . -. -. - - . . -. . . I CERTIFICATION BY H WQUARTERS RESEARCH FACILITY OFFICIAL I

(Chief Executive OM-r or Lepally Responsible Institutional official) I osnty that lhs above IS lme mned and mmplefe (7 U S C Senon 2143)

n n t , I DATE SIGNED


The following sites have been reported by thefacility.

Regisbation Number: 93-R-0380 Customer Number: 1344 Facility: SANTA CRUZ BIOTECHNOLOGY, INC. 3\45 'DSuLJa(Y A J ~ J G C

SANTA CRUZ. CA 95060 (831) 457-3800

SAN JUAN RANCH 4655 CAMATTI-SHANDON RD SHANDON. CA 93461

See r e m e Y d l m( - w

This repm rr mqu8wa by law (7 usc 2143). Failure lo repon acmming to the rspulallonr an lnlersoensy R e p i Qntm No result in an om, lomassand desist aM lo be r u b w to p e ~ l u n as W d M fw in SDdion 2150. sddiurnal inhnnatirn. 0180-WA-AN -

t h a ~ ~ m h u ~ m u h m ~ c a n M and hs e a r n * rush -I uwa mt uKd m u s t b Y t a o % d t a ~ h M a t I

UNITED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PUNT HEALTH INSPECTON SERVICE


TOTAL NO. OF ANIMALS

(. REGUTRATION NO. C W T O Y R NO. 85110382 3288 FORMAWROVED

2. HEADQUARTERS RESEbRCM FACILITY ( N I M ~ d A 6 n e s s as W e r s d WMh USA4 r n ~ ~ c 0 d . 1

PHOENIXPMRMACEUTICALS, INC. 530 HARBOR ELVD BELMONT. CA 84002

OMB NO. 05780036 I

7, Hamsters

8. Rabblts


5. Cats

6. Guinea Pigs

1 12. Mher F a n Animals 1 I 1 I I

1

13. Other Animals

2) Esch ptinclpl InverUplor has crnrlderad slimstiver lo painful pmcsdum

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL (Chlef Executive Offlcar or Legally Respo~ lb le IMUtuUonal official)

I csrUfy W t the above is t ~ e , mrreu, and mmptate (7 U.S.C. Sklion 2143) SIGNATU

m

APHIS FORM (R.phc" VSFORH 184S(OuM), whkh b ob.o*L. PART I -HEADQUARTERS (AUG 91) /

ANNUAL REPORT OF RESEARCH FACILITY 2. HE*DW*RTERI R- F A C I W (N.me sndA&+ess, a. ~LWWM & USM.

Mude*CadsJ

(TYPE OR PRINT) CALIFORNU STATE UNNERSlTY HUWOLT ARCATA HUMBOLDT STATE UNNERSIN

I ARCATA. CA 855218298 I I

, REPOml lm F ~ C l u n (us1 all Icedm wwa v l l m ~ s u*. h e 4 o r d In m u mum. mtinp. UMlnp, uupnin*nf.tlm, or hUd fw M. pwpolsr. M.d, M U - ah* . $-.) I

FLWUn C O C * n o l w ~ J CALIFORNU STATE UNNERSlTY HUMBOLT ARCATA ARCATA. CA 85521-8298

5. Cats I I 1 I I 8. Qima pias I

11.F'lpr

12. Omar Fann Anlnuls

13. O l b Animals

CERTlFlCATlON BY HWQUARlERS RESEARCH FACILITY OFFICIAL (Chld Euoutln, Officer or Legally R . . p o ~ b l e Institutional offic1.l)

I caMyavl Ihe abava Is bw. mmzl. and mmplet. (7 U.S.C. Ssnion 2143) SIGNANRE OF C.E.O. OR I N S ~ U T ~ ~ N N OFFICIAL lONAL OFFICIAL (Typs orplfnt) I D A ~ SKIWED

1

I I I APHIS FORM 7023 (-1- M FOW I C U (Odn). tbmh Y PART 1 - HWQUARTERS

( N O 91)

. a d u r n antonMlm

U N n W STATES DEPUnUENT OC AGRICJLTLRE 1 REGDTRAmND C U l t Q E R NO ANNA1 Ah0 PUNT HEALTH INSPECTOON SERV CE 83-Rm13 1836 FORU IPPROVED

OUB NO MIWO3U I

M~MII COY.nd . - .

M, &W i&iuino p.in o r d i w ~ T N NO. w me mmal m~t imw.0~ l.Iwrd?. s-,wlldm mmem~1s.ndkuhlm~usad1opmpll.1. OFANIW W d h n Raguimlmr h d d k u u i n w$.liIm%s, or d u a w lm*Mq amIhUcCulgrlc, orwanqullldg drug8 -!a

W i n g . wing, ma *r. .aanpmvinp win or hlw . d & y m c m me p m a ~ m , nrultr. or (ch. C + W n * n U . mnhlad dl- tom anillll. Intrpwdsw4 d m l u m i n p . -. D+E) -. W inMlYlnp M .nd for*hm .ppmpilt. upnmnb, -. or trb. (A" e w m n 01 w r p y h ~ ~ n n pun. d i m t r , n mrlhMr, mrlgrr, n m ~ n . w m g p h r r r ( i . ( n n h R m 9 1 W m e d l w a m S u*adp.in- tnnquil'inp dwga vas ~ ~ e s n d ~ r u m r v c h ~ s - m l d wF-=- mllMng d v . d. murtbea!Bch.dmmrwmJ

CONTINUATION SHEET FOR ANNUAL REPORT OF RESEARCH FACILITY

(TYPE OR PRINT)

11/2812003

APHIS FORM 702% I R * p h n M FMUl 1W3 (Ost u). whkh b- (AUG 91)

PART 1 - HEMQUARTERS

I 2. HUWU*RTERI W E U C H FACIUT* (Nem endlddur , a 8 r 4 ) M . d M USD*.

hchrd.ze.code~ CALIFORNIA STATE UNNERSIN HUMBOLT ARCATA HUMBOLOT STATE UNIVERSITY ARCATA. CA 955214298

I California State University Fresno ANNUAL REPORT OF RESEARCH FACILITY 5241 North Maple Avenue. Ms Ja 58

( TYPE OR PRINT ) Fresno. CA 93740

I I Telephone: (209) -278-2636 I

FAClUTY LOCATIONS (S i ln ) - h m a d UsW

REPORT OF ANIMALS USED BY OR UNDEl

Rats (except )

4. L%Qs -.

5. Cab

6. G u k Ws -- 7. Hsmstws

8. - 9. Norrhum~n Primatw

10. Sheep

11. Pips

12. Omer Farm Anbrvls

m(X OF RESEARCH FACILITY i A t W 8ddlWon.l rhnb U mnutv or u u APHIS Fonn 7023A 1 1

17

I 31 FTdssbaIEI IOC~W rt.ndards gmming Vu Cam. Vutmnl and us olanimb, inddng .ppmpode ur. damslatic, m l W s , n d mnqulliring dws, phr 10. durn, m-afollWno ahla1 mra

t&mQ. teelhp, s u r O q . MDxparlmsntsIim m f d l w d bylhir nnum IadlHy.

3) mis fsdQ h idhdng tohs slmdaar m d mpuldicnr mdor t k A d and it h u muired mat a ~ i m s lo hs rtmdards and WUsUonr be r p W and axpainad byhs pnnc(pa1 invarUgUor and .pl Mlluatmsl Mlmal Urn md Use Cammime (IACUC). A rn- d .Ilsuch auptlons b nt.ch.6 l. this mn lu l wrL 1" addwon to i d a w w ma IACUCappowd excep$tma, lhk .urnmar, In, bti* W N l m d Va WMPnOM. as Yell asthe and nmkd.n(mah M&d

4 i% 8nMlnp Wvnmlun hx ms n-mh I f l~ I t y has w p r w u w M n a y to sum ~u p-on d i w u a w vedrury unarm IO o m r me a m w q &omr d mm.1 un n o ss

CERTIFICATION BY HEAWIJARTERS RESEARCH FACIUM OFFICIAL

11.PiQs I I I I 12. Other Farm Animals I

ANNUAL REPORT OF RESEARCH FACILITY (WPE OR PRINT)

2. H U W U I l l m s RESEmCH C A C l L m (N.m.sndlAtnm, aawslasd m USDA. ncl& Zp Gods)

CALIFORNU STATE UNWERSlPI FULLERTON CIO OFFCEOF GRANTS 6 CONTRACTS. W I i 2

T N t ~ b - b y h ( 7 V X 2 1 0 ) . F . H V . I O 1 . P O r t . m m k p * , h . q u l a U r m a n S‘anmwWfu I n t m g m c , R ~ C m W WK v ~ h n o r b m c r u ~ m ~ 0 ~ . u b l . ~ l m p n a k r p m M . d f u h ~ m 2 1 0 . MO-1 1-on. 0 1 M M A 4 J 4

UMTEO S T A S DEPARTMEN? OF AGRIWLNRE 1. WIIIIUIK)N No. C U n W R No. U1IYICUY)PVJrrHEUTHWPECXWSEFMCE 93-R-0417 1.340 FORM APPROVED

MB NO. 06- I

I + RCWRTIIQF*CYITI ( U I 1 d l l - h n ~ m ~ u u u d l n r * u l ~ . ~ . U d k g . w ~ , u k l d ( o r h u p r r p o u . ~ . O d l ~ .h*lnmcurv.~ I

FAcKm L 0 c l m w U h . I

Sae Atllchad Ultira 1

ANNUAL REPORT OF RESEARCH F A C I U M (TYPE OR PRINT)

I I . H L U I O W R T E ~ ~ R E ~ E I K ) ( F ~ ~ ~ ~ ( N ~ ~ ~ A ~ . ~ S - * ~ U S D * ,

bww. zp coal CALIFORNIA STATE UNIVERSITY HAYWARD S C W OF SCIENCE HAWARD. CA 94542


I

2. IK*WUAMERS RESEARCH F A C I ~ Itdarn am AWIM.. 4s mgmmw v~ UUU. -*C=-w

CALIFORNU STATE UNNERSITY LOW BEACH 1250 BELLFLOWER BLVO L O W BEACH. CA 80840 f310)9&4454

Natural Sciences Animal Facility

1. REpomNQ F I c m (Lnt all louuons m m a n u l s m hwud a uted in .mul ruldl, trunp. W n g , aoprimnuflm. uhddfu- p-. m h eddluaul s h m if n-ary.)

F * C U n LDWTmm(r(uJ

See A l h h d Liniq I Satellite Psych Animal Facility

41 Th. aUmd8ng Mlnnadan for thil rearm lsaiihl has qpmpnm w w lo n w n h a m u o n d-u M U i n u y u a aMlo ovuu* hl.dsqulsydaha I lp& Of aniMI - and use

3

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIM (Chief Exocu(lw Officer or Lagally R..pomible Inmtitutlonal dncla)

PART 1 HEADQUARTERS (AUG 91)

/

"" 1 '/qy

DATE (UONED

11 / 25 /O

This r m is ngulnd by Uw (7 USC 21431. F m n m n p o n m i n p m lh npulalimr cm S..nua~s&k mum n m d r m w e and 60.1.1 IM to be S Y ~ W M mwe e m d w t ~ I" 2150. dabon* hfmm,lbn. olsoocu MmJ.F$Zm

4l lhatandingwtanadmforhh r s u t r s h ( a d l i t y h . 8 g p m p l M m ~ ~ t o a u m h m r m d.d.qu.UmMhmryunndmDusMlhadewxydoma aspa, olmlml rm ."d "ra

I CERnFlCATK)N BY HEADQUARTERS RESURCH FACILITY OFFICIAL I

UNITEDSTATES DEPARTMENTOF AGRICULTURE ANIMAL AND PUNT HEALTH INSPECTION S E W

ANNUAL REPORT OF RESEARCH FACILrrY (TYPE OR PRINT)

12. W m r Farm hnrhats

4 Peromvscus

I I

NOV 2 6

1. REPORTING F S l U T I Wsl d l l a u t i m *h. m w s - hc.md wu..d in vbul-. wnp. W w , m vpnmmwon, w h*dW hu pu-. Amh mnhd l n ~ r y . 1

FACIUTI L ~ T I o # I l * ~ SeaAltachedUsUnp (page 2)

1. REQmTRATDN W. CUITOYII m. 03ROUB 9185

. %\3

FMM *PPROMD OUBW. 05DM136

2. HEAoWARTWI IIEIE*RCH F- (NM. W A e & m , as mgwww vm U r n , n c M . Z P C e a j

UNNERSrPI OF CALIFORNIA RNERSIDE OFFICE OF RESEARCH AFFAIRS 2W UNNERSlM OFFICE BUILDING RNERSlDE CA 92521 (808) 707-5635

I2 k LJ I b i )

,3\ 3s I2

I U L ~

OF RESEARCH FAC1k.m UNNERSlM OF CALIFORNIA. RNERSlM

(TYPE OR PRINT) OFFICE OF RESEARCH AFFAIRS

, 200 UMMRSlM OFFICE BUILDING RIVERSIDE. CA 92521

&ti&. or hmdtOlWi"

2) Each principal mvsaiqator has mnridarad slianltinr lo painM p m d w .


4) The anendlng vamnnanan lor mt, research lacil~ty has apprwnrtc a u m d l y 10 msun me p r o w m dadaqu.ia reutinuy u r o IM lo w e e me d q u a c y domer a.p.n. 0I.nlm.l car. and use


I ~ - - . . . . . . .

1. HEMQUARTERS RESEARCW FACILIPI (N.m mdA.#ess. ar mg&wadr)n USm. h l u d . q C M I )

UNNERSITY OF CALIFORNIA. SAN DIEGO 9500 OILMAN AVENUE LA JOLLA. CA 02093 (858) D4-8BJ5

(Chlef Executive OMcer or Legally Responsible Institutional onclal)

ewPdntJ

PART 1 - HEADQUARTERS (AUG 91)

1. REPDRTiffi F A C R I N <(Us1 all l o ~ t i m s *hse a n i m I 1 m W r e d or used in aduu meam, a m p . UrUunp. or erperimmtion. w haid IW mas purpcra. *rum additimal s k u if nccesrav.)

FACIUT* LOWTYIW(S*rJ See Attached Listing

ATTACHMENT A

Facility Locations (Sites) USDA Covered Species

1011 102 - 9130103

SCHOOL OF MEDICINE DEPT. OF BIOENGINEERING

Basic Science Building Powell-Focht Building

Clinical Teaching Facility

Elliott Field Station

Medical Teaching Facility

DIVISION OF BIOLOGY

Pacific Hall

Surgical Research Laboratory

SCRIPPS INSTITUTION OF DEPARTMENT OF PSYCHOLOGY OCEANOGRAPHY

McGill Hall Center for Marine Biotechnology and Biomedicine

Attachment B

Registration # 93-R-0437

Species: Hamsters Number: 170 Project: Photoperiodism in Hamsters

This project, a continuation study funded by NIH, examines the effects of light exposure on the hormonal and behavioral status of hamsters. Since the hamster biological clock is extremely sensitive to low light levels and other environmental changes, direct visual observation of the animals must be suspended during certain phases of the study. Considerations of this sort have been addressed in a publication of the Society for Research on Biological Rhythms, which recommends that variances be permitted.

In these studies, the locomotor activity andlor body temperature of experimental hamsters is continuously monitored by a computer system. To an experienced rhythms investigator, the patterns of computer records can reveal more about a hamster's health status than direct observation. Therefore, during phases of the study when animals are housed in isolation the locomotor activity pattern can serve as a sensitive health record. Following IACUC review and meetings with the Principal Investigator, the protocol was approved with the requirement that health observations be made daily, including weekends and holidays, by review of the locomotor andlor temperature records of each hamster.

Cage and bedding changes are less frequent and are carefully scheduled to minimize disturbances to biological rhythms of the hamsters, based also on the computer records. Food and water are available ad libitum.

Regular audits of this project have indicated that the animals are well cared for and there are no adverse effects from this computer-assisted health monitoring program. The protocol fourth year rewrite received a full IACUC review and approval on 3/19/03.

nos npcn a WJ m ~y 11 (7 usc 21431 FI .&~ 10 r * ~ n -m np m a* r w m m ur % m * u ~ O I w .a- 0- res.11 n yl W a r m srs . and aer sl md m M 1*0m to wW0.r P m o m (or .n SrUm 2150 0 1 ~ - W U ~

U N ~ O STATES DEPARTWNI OF AGRICULTURE 4. I-now m. CUIIOW m. *NIW UY) PUHI HULTU INSPECTION SERVICE 83430438 8107 FORUIPPROMD

Msm 051KO.W I

I ~ .~ ~ .. .-

(805)8853807 3. REWRTIW F F l W T I (Li* dl 1mtlmuhaeninul.- hl.d a uud in a m 1 nt.rch. w n p . Dlblinp, wamMmnDtion, w kM hvolUu purpcu. Mch aMibwl

s h a u if mw.1 F A C W LOCAmNS(&e8)

Sea Attsched Listinp I


REPORT OF AMUIW USED BY OR U r n CONTROL

A. I L NuWd

I I . I E L W U U T E R S RUEIllCH FAClUn (N.rrn and-, mssnpbWW U S M .

hdudsam~ UNNERSrrY OF CALIFORNIA. SANTA BARBARA OFFICE OF RESEARCH M A -. CA 83-06

'"rgeq but M vnuswhvruch

7. Hamsters

8. Rebtits

1 12. Other Farm Animals I

13. Other A"ims!3

?kc& ~ o o ' n e e b

TOTN NO. O F * H I W

(cob. c. D I E )

4 m c ~ M m g M * I n u i a n f M ~ ~ h d I i N h ~ g p m p n ~ ~ m - h . ~ d ~ ~ ~ ~ l y s ~ ~ n d m ~ ~ ( ~ ~ e ~ d ~ .rW dmmul a m end me

I CERTIFICATION BY lEMQU*RTERS RESEARCH FACILITY OFFICIAL I

0 P m m d l y uc9kWe atandams govming Hmm, UmumnL md usa dmids , induding mpiwklm u s d mmWk uuwr n d m u l i d n g d ~ g l . prim LO. duIIcg. and WlwAuing mu.1 -mh. IeasNnp. Ult8w. tunpry. awmmnwm -fa& by HI nuucnMIii.

CONTINUATION SHEET FOR ANNUAL REPORT OF RESEARCH FACILITY

(TYPE OR PRINT)

4 T l m a n a a n g ~ r u ~ n t o r l h l s nwdt h d l i h h * q ~ W ~ ~ L O n a u n ~ ~ u m d . d . q l M u * d r u y a a n d M ~ a h . a d q u m e y d o m a aweas danind cam mu uu.

I CERTlFlCATlON BY HEADQUARTERS RESEARCH FACILI1Y OFFlCUL I

I 1. lECWWdTERIlREMUCH F- rn andAdmrt , unObCsnd vm OSM,

m q c ~ * l UNNERSlM OF CNIFORNU, SANTA BARBARA OFFICE OF RESEARCH SANTA BARBARA. CA 931W


1. The University of California, Santa Barbara Office of Research Santa Barbara, CA 93 106-2050

2. Sierra Nevada Aquatic Research Laboratory Mammoth Lakes. CA 93546

3. Sedgwick Ranch Reserve 3566 Brinkerhoff Road Santa Ynez, CA 93406

4. Santa C w Island Reserve Santa Cruz Island, CA

University of California, Santa Cruz I


I I ~ nign sneer Santa Cruz. CA 95064

I 2. HEMWARTERSRUEIRCH F m ( N m . n d A d d . r * a ; ~ ~ O W

~ C ~ ~ , Z P M W UNIVERSITY OF CALIFORNIA. SANTA CRUZ 1158 HIGH STREET SANTA CRUL CA 8SMY (831) 458-2931

By The Wm* I mnd8UmN.u -. w r g * y ~ f f u l w ( n mu*.nimundiol*hMhau"dappoWi.U hld fu w tn I dm i I mnd-lnW4m 1 -UWc.nUWU4 u-IIdw d w d d

I. REPORTIIIO FACIUTI (Ua all locations u l u n a n i m l s w h w u d u W In &dual nUrm. Wng. M h l q , u Irp.llm, UhM (or--. M.ch I- 1 r n u y . )

FACILITY ~oc~rnw(ahu~ ~ e s A- bstinp I

5. Cats

6. Guinea Pips

7. Hamsters

- - -

a. Non-Human Rimam

10. Sheep

I 1 Pigs

13.0mer Animals

cetaceans

mustelids

I APHIS FOR

EADQUARTERS (AUG 91)

pinnipeds I 1 18

2

2

18

2

2

I 2. H U D ( X U I I 1 R I -UI FACILm (NunsaMAW.u, u- *0n USDA.

ANNUAL REPORT OF RESEARCH FACILITY -*-I W P E OR PRINT) UNNERSITY OF CALIFOWLA WHITE MOUNTAIN RES.

89W G l L M ORNE


I FACILm LOWrnWlrh.)

PART 1 - HE*WUARTERS ( N O 01)

See A n S M Listing Owens Valley Labs Barcroft Labs

ANNUAL REPORT OF RESEARCH FACILITY (P/PE OR PRIM)

I '2. H u o w * m w r U E U l C H F & C U N ( N M * M 4 ~ u n D U l n d ~ U S D I I .

-@-' C V THEffAFWTlCS 1651 PAGE LUU ROAD PALOALTO CA LlLW

APHIS Fonn 7023 Slte Llrt


Registration Number: 93-R-0448 Customer Number: 8847 Facility: LYCHRON, L L C

2589 WYANDOlTE

2569 WYANDOTTE MOUNTAIN VIEW. CA 94043

1312 N. MORGAN [wwtss AJsl-s~ ) hu\;rJ ((4- TURLOCK, CA 95380 .& hYr ' T~ r locL ,W 'lS3BD

Facwr.

-

PLLERMED LEISH LAB , / PkG€ 82/82

ANNUAL REPORT OF RESEARCH FAaLrrY ( l w E OR PRTNf)

6.

L OuhrRp

7. nmmma

L m

3 I

i

aoa (91 -e-- ab3

ANNUAL REPORT OF RESEARCH FACILITY (PIPE OR PRINT)

I 2. IUWU*IITERI RESEARCH F l C l V l l f N s m mdMd..a. u rsp*md uh USO*.

MvdsZbcmaJ XOMCORPORATION 2810 SEVENTH STREET BERKELM U 84710

I. REPoRnm FACIUTI [ust .it ~ x a t ~ m s mere ~ M I I warn mad or YSW in aaua~ mum taanp. lumlng or cmnmmtanm or hda for mess pum-1 m c n aaaluonal shml1 n-m,y I 1

FACILm LOCATK)W(smd

NEREUS PHARMACEUTICALS SAN OIEGO. CA 92121

ANNUAL REPORT OF RESEARCH FACILITY (PIPE OR PRINT)

4) me altenaw wmnanm ror ors reurol fmaltly hu qprnpnale a u m t y UI mun me muuw d tdquau mmn~y care ma to -8a me aaeausq of other asp- of mm.1 cam and us.

I CERTIFICATION BY HUDQUARTERS RES-CH FAClL l lY OFFICIAL 1

I ' 2. H-UARTERS RESEARCH FAClLm (Name sndAdbsrr, ar r w s l a W urn USOA.

inziude zb cad.) NEREUSPHARMACEUTICALS 10480 WATERIOGE CIRCLE SAN OIEGO. CA 92121

(Chief Executive W c e r or Legally Reaponslble Inatltvtlonll offlclal) I caafy lha the ram ta ma. sonm am wmpet. (7 L S C S a m 2143)

SIGNATURE OF C.E.O. OR INSTITUTIONAL OFFICIAL I hAME L TlTLE OF C.E.O. OR INSTITUTIONAL OFFICIAL ITyw or PnnlJ OATE SIONEO

0912612W3

APHIS F O R M 7023 IR.pUcn VS FORM 1843 (0~188). d h h &*&a PART 1 -HEADQUARTERS (AUG 91)

11 PI,,. I I -


12. Omsr Farm Anlnub I I I I I I

I L ~ l U U l l C H F - ( M n * u d I d d . . l , u ~ m L I S D I .

mra.?@c=-) VICAL . INC. 10380 PACIFK:CEhTER CWRT SAN MEOO. CA BZlZ1

NOV 1 7 2003 d

Nov 14 03 12:12p Matthias Rath, InC. quu-atltl- f IU I r ' . '

I (860) 2W-7W 1. WRWYOFKIUN ( ~ . 1 ~ ~ ~ ~ n ~ * 1 ~ ~ ~ d u ~ . d h r 0 ~ 1 m . r q ~ m h . w r m r u a . ~ m ~ k r - . - - ~

.ham lr*uu.n., F * C U I I L O U m Y W

Sea A~~

I I

OCT 2 8 2003


I . HEIWU*RTERI nEIURC(I F A C W (NYIR B n d A d m ~ , aarsggasd *m USD*. ~ z b * ~

ICHOR MEDICAL SYSTEMS, INC. 6310 NANCY RIDGE DR. XI07 SAN DIEGO. CA 82121

C. - d I D . H.mrdn#mhuom I C M d r m d . u a m d " m n M i m I I

TOTN NO. 0FANlUN.S

(COk. C . 0.E)

--

8 NoMuman Primatea

10 Sheep

6. Guinea Pigs

7. Hamslers

6. Rabbits

12. ClIw Farm Animals I I I I I I

13. OUu Animals I I I

3\

CERllFlCATlON BY HEADQUARTERS RESEARCH FACILITY OFFICIAL (ChW Exacutivr, M a r or Logally Ra8ponaIt.h InsUtuUd 0fflci.l)

I DATE SIGNED

3 \


I 1. H U O ( Y I I R T E M R E S E b R C n F * U m ( N n u . M A d d u c u ~ n h U . ? n A

M * C o a ) CIiEMlCC# I-TIONAL. W. m20 SNOCE OAK WWE TEUECULA. CA 02580

U\ '~ Thrs . a m is nguimd by l a (7 USC 2143). Failun lo npon rmminp m h. npuhl lm un h-sidetor Inm- RSDon Cmtml M nrun In an 0ld.r lo cease and deist and m M subm lo pamn u pmiw adin %cum 215.3 amtima1 intomutim. O I L U ) - M M N

UNITED STATES MPbRlMENl OF AGRICULTURE 1. ~ ~ I Y ) N No. W T O Y R No. W l M 4 L U I D PUNTHEALTH INSPECTiON SERWCE 93-RM87 18788 OW W, m l w o ~ s FORMLSPROMD 1

Same as above

ANNUAL REPORT OF RESEARCH FACIUTY ( lYPE OR P R I M )

- - - - 12. OttWFarm Animals

13. Omer Animals - No animals ;overed by the Animal klfare ~egulations

I I. ~ ~ ~ ~ ~ ~ S R E I E * I I U I F*CIW (~.n*.m~ddur r r m r n u s m .

m w w XENO PORT. w. 3410 CENTRAL W R E S S W A V SANTA UARA. CI 951351

(Chl.1 Exacutlw ORcw a Legally Rnponr ib la IruHtufJwl M k W ) I amty mat rm aoas I8 bw. mma. and m m W (7 U.S.C. Sam 2143)

S I DATE SIGNED

APHIS FORM 70'23 ~ ~ M F o R Y o ~ l f O c t n ) . ~ k h bob- PART 1 HEAOQUARTERS (AUG 91)

NOV 1 7 Uu3

I

ANNUAL REPORT OF RESEARCH FACILITY 1. nuwuIRTm8 RCSWRCH F A C I ~ wm aw*6maa, u ngarsb wn us^.

Mvd. Zb coaJ (TYPE OR PRINT) UB RESEARCH IhTERNATIOWL. INC

3030 BUNKER n u STREET. STE + is SAN DlFGD C A 921M

I -. . . - .- - -, -. . -- . - - (6lQ)4614KJl

3. REWllTlffi F I C l U n (Lilt 811 loutlons mimU vas hovUd or used in Mlul nurdl. Wnp, lenlw, orwmnm. orhdd hx lu pu-. math dditimu 8 h . a if m a * . )

F * U m LocATDYllah.) I

ANNUAL REPORT OF RESEARCH F A U U W CTYPE OR PRIh'T)

ANNUAL REPORT OF RESEARCH FACILITY 2. H U W U U I T E M RESEARCH FAClUlY ( N l m mdlddsu, ar -ulh USm.

~abz4.cod.l (TYPE OR PRINT) W J I . INC.

3525 JOHN HOPKINS CT

1 8. Non-Human P"matsr I I 1 I

8. Guinea Pigs

7. Hamsters

8. Rabbils

10 Sheep I 11. Pigs

I 13. Other Animals 1

212

4) me *nendinp~l~WIm irx mts nurm ndlityh.~ appmplme aummilylo m u m VI. muiYon d &quaUwlstiruw- md lo weme M sdtqumolom q e M ofaniml care and uw.

212

0. Gvinea Pips I I I I I


1 1 PkJa

12.- Farm A n l d s

13. OMer Animals

I 2. H E M Q W T E R E ~ H F A C l L m f ~ n d ~ r ~ * h u s Q q

-+'coal CALIFORNU FISH 6 WE 1451 SHAFFER RD S M A CRUZ. CA 85060 (831) 469-1728

41 T e s m ~ n p v M l r u r i n ~ h ' ~ ~ h d I ~ h u l w m p l a u h M ( y b - ~ p w b i m d ~ ~ c . . . 8 n d b ~ h . . d q u y d o h r asmasdmhml~.nmluu.

I CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFlClAL I

1. R E W R T W G F m ( ~ l t * ~ ~ h l . ~ s * * . h a n t d u u ~ h ~ ~ . U U n p U * h i n p . u o p m m Y d m , u h l d ~ h u p r p o o o . M d l M d i ~ I W if--ry)

F * c u T y L O U ~ )

See Anached Llsfinp

T 1 -HEADQUARTERS

NOV 2 4 81-4

Thls n w i tr rsqu id by law B VSC 2143) Fs8lure lo r e rmrdmp LO the npuleums mn see rawme sac f a Intuagncy RepM Ca lm No muit in an ordcr lo ease and dessl a M lo Da ruead lo m i t i e a s p m v l d ~ r u ln *dim 2150 s m ~ u ~ n l inlutmurn 0189-WA-AN

UNITED STATES DEPARTMENT OF AGRICULTURE 1. REOlalRITnN NO. C-R HO. ANIMAL AND PUNT H U L M INSPECTION SERVICE 83-R0472 20%4 FORM APPROVE0

OMB NO 0578M1Yi 1

1 (714) 52B2892 5 REPORnNQ FACIUTV (Lwall IOE.UW *hem m m s w m h u e d m used in aawl reearth. W n g , t d l n p . u m m n ( . u o n rn Mid mthw p w Athm ada8u0~1 w If necessary)

F * c l U n L O C A m W ~ s )

pd d. u/.d h. %&3, F/& . &PPJ3


13. Other Animals

I

I 2. HUWU*RTERS RESEARCH FAClUn fN.ma mdA&%ss, as W d d h USDA,

[email protected] USA UNIVERSEBBIOENGINEERING, INC 2021 W. C O M W E A L T H AVE., SUITE B FULLERTON. CA 82833

4) The anending ~ t . n ~ a n fw tNs rerearm fadlity tea a-rim authmty to en- V. mULm d aaqule Vanw un .nd lo o~ne. me sdequ~y d oVw a m D4anImi can and u s .

I CERTIFICATION BY H WQUARTERS RESEARCH FACILITY OFFICIAL I I Wltlb hl the &OY. 6 IM CV&l:& & ~ 1 8 (7 L s c S& s43)

'

SIGNATURE OF C.E.O. OR INSTlWTlONAL OFFICIAL N N E L TITLE OF C.E 0. OR INSTlNllONAL OFFlCUL (Type or Prlnlj I DATE SIGNED

Thlr r e W or q u m d by l h (7 USC 2143) Fatlure U, repM scmding U, me w u b m a can See rsunrcllde for I n l e n m w R.Dn Canud No nsult in an wdao c-se and dews1 and lo be rubpa lo pnelues 8s prmded Iw m Sabm 2150 ~WIUWI in(wrrrUm 01M.WA-AN

5. Cats I 8. Guinea Pios

UNITE0 STATES OEPARTUENTOF AGRICULTURE A N I W AND PLANT HEALTH INSPECTION SERVICE


8. Rabbits

9. Non-Human Primatea

10. Shee~

1. REGI(ITR4TDN NO. CUSTOMER NO. 83-R0473 21387 FORM APPROMD

OM0 NO OS7OW3B I I

2. HEIWWRTERS RESEARCH FXILITI (Nama and mu, as rsp,slmd m USDA, meL1DCodsJ

LA JOLLA BIOENGINEERING INSTITUTE 505 COAST BLVD. SOUTH LA JOLLA. CA 92037

11. Pigs

12. Wl%r Farm Animals

13 Dher Animals

1. REWRnNO FAClUrY (Lisl 31 lkaUons*lha animlr WE M u u d m u s d in .ctwl rawurn. lesung. lcuhlnp, w m m u t i o n . m hdd for m m pu-. Attach .Mlumd - l -ry.t

CERTIFICATION BY HEMQUARTERS RESEARCH FACILITY OFFICIAL (Chid Executive Omwr or Legally Rnponslble I n r U t u U o ~ l omclal)

rinf)

PART 1 - H EMQUARTERS

UNITED STATES DEPIRTMENT OF AGRICULTURE 1. REGISTRATION NO. CUSTOUER NO. ANIMAL AND PUNT HEALTH INSPECTION SERVICE 936-0474 20731 FORM APPROVED

OMB NO. 057W36 1

,-- , - -- - 3 REFQmmG F I O U W 111.1 31 i w l ~ m s mem momlsmr hDvvd w u s 4 am aaul nseaM. mng Ieammnp uax+wm~Um w hdd fw msa pv- Amch aadlt~ml

mwe ir n-rv) I F m W UICAmws(LsJ

8. Guinea Pigs

7. Hamten

8. Rabbits

I umty that the above ns tn.8 cor;piaw m m p m (7 u s c stwon 2143) .

SlGhATUR I DATE SIGNEO

9 Nan-Human Primates

10 Sheep

11. Pis


SEP 2 5 m b'

-3-

-

e- eJ- -&- -€!+

7 Hamsters

8. Rabbits v


10 Shew

m(s r W is rauirad by law 17 UX 2143) Fallwe lo rewrtawdlnp to the rw lamr M Sse re- .la for InImpsncy ~ c p o n canw rsrvll in an ordeto w e a n d d.u# and to be Wblect to prultlar ss m n d d f u m W o n 2150 addlbm mlomrtlm 0180-WA-AN

I l . P i


UNITED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PLANT HEILTH INSPECnON SERVICE


1. REGISTRATDN NO C W T O N R NO 83-R4476 3820 FORM APPROVED

OM0 NO 05794038

1. W W W R E ~ C H F G I L I W f M r n M d A W n u , a r w m a n d ~ h u s m . vlshrd. Zp MJ

MONTEREY BAY AQUARIUM 888 CANNERY ROW MONTEREY. CA 83840 (rul)srs-dew

CERTlFlCAllON BY HEADQUARTERS RESEARCH FACILITY OFFICW (Chlef Executive OWicer or -ally Responalble 1n.tltutlonrl offlclal)

I CaM~Ihat the a h is true. mnscl. and mmplete (7 U.S.C. Section 2143) ( DATE SIGNED

3 REPORTING FACIUW ILrS all IxaUmr w h m anlmlr w e Mwsd or used in a m m ~ r m . I- Itaciwg, w e"pmnM.Ucn w I*oIm !Mu, pu-s Attsch add818~1 sheets d n-v 1

FGILITY L O C A ~ W S ~ J

See Attached Llstmg

886 Cannery Row, Monterey, CA 93940

No o t h e r f a c i l i t i e s

'

NOV 2 5

13. Mher Animals

Southern Sea Ot t e r

-0- 10 -0- -0- 10


%ere- tlae 101 lnlwagacy R ~ M w t m NO 50 MddMaI mn~LICn. 0180-MA-AN

I . REGISTRATION NO. CUSTOMER NO. 93a44n 200% FORM APFUOVED

O M NO. 0574M38 I

1. HEMQUARTERS R€SE*RCH FACILIN ( N m a n d Adds-. sr reg.& m USDA, mud. 4 code1

SMITH -KEITLEWEU EYE RESEARCH INSTITUTE 2318 FILLMORE STREET SAN FWNCISCO. CA 941 15

6. GuiMa Pigs

7. Hamstar

8. RaWi

9. Nan-Human Rimmtsa

10, S k e

1 13. Othsr Animals 1 I I I

11.Figs

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL (Chief Exacutive OWI-r or Leaallv Rrwnalble Institutional officlall

3

I

I I APHIS FORM 7023 ( R w l u n VS FORM 1841 (m n h rhkh i. -sol& PART 1 - HEADQUARTERS

(NJG 91)

3

12. Oha Farm Animals

I

ANNUAL REPORT OF RESEARCH FAUUTY L ~ - F Y U n ( m * f i - n w u a w m u r m

(TYPE OR PRINT) --- V ~ B a S Y S T E I C S

W r n but not I yel"&la%dl


TOTAL NO. OF ANIMUS

ICot.. C +

I 2. IIUDPWS(TEna RW€4nCH FAclUTY Wme.M*ddmu. u m @ t d * th U r n .

huJ"*LpGmJ IN-VIVO TECHNOLOGIES. INC 8 1 W MITTEN ROAD BURLINOAME. CA 94010 IRmi miMm

1 9. Non-Human Pdmatea I I I I

5. Cats

6. Guinea Pigs

7. Hamsters

8. R a b b i

lO.Sh8ee

11. Pigs


1 3 . 0 t M Animals 1 I

i /

SI I DATE SIGNED

44 ..IN9 f 'I"

ANNUAL REPORT OF RESEARCH FACILITY (TYPE OR P R I M )

I 'I. IbEMRUIRTERII RULLKn FACILITY ( N m a M A W n r r . .a npllfind wlh USOA. - ze m)

11808 SUSAN DRIVE GRANADA HILLS. CA 91344

I ) me a~ecdinp vaadMMn fM ihts nseam k ~ l l l y has s p ~ m ~ n s ~ a u ~ ~ l y m .nw. h e pmvisim ofaasqus~, WUK~~U~Y weam m ommea m 3sglucy dotha dan~mal on a M -

'

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL (Chief Ex.cutlvo Orricer or -ally Reapo~ible l ~ t l t u t l o ~ l oMcial)

I ceNty lhat h e above 18 bun, wrrsct. and can@& (7 US C Section 2143)

APHIS (Rglom FORM 10-23 MI. . r ~ e h h PART 1 -HEADQUARTERS ( N O 91)

PnntJ

DATE SIGNED

~ I o t J 3 0:

Thls repm IS required by law(7 USC 2143) Fatlure I0 repon -ramp lo the regulaon9 csn k e attached tam, la Interagency Repon ~ w w i NO

i m l l in an d e r lo cease and dalst and b be subled lo p e ~ l t ~ n as monad f a in W o n 21' 8ddlllMal mloml lm

UNITED STATES DEPARTMENT OF AGRICULTURE 1. CERTIFICATENUMBER: 93-p,-0483 I FORM APPROVED ANIMAL AND PLANT HEALTH INSPECTION SERVICE OMB NO 0 5 7 9 ~ 3 6

CUSTOMERNUMBER: 23949 I M P Biornedicals

ANNUAL REPORT OF RESEARCH FACILITY 15 Morgan Street (TYPE OR PRINT ) Irvine, CA 92618

ID: 23949 550 Center Hall Road Cochranville, PA 19330

FACILITY LOCATIONS ( Ples I - Sw Atache5 Linng

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILIR 1 AtUch Mdltlolul s h n t l If neCMS8NOr US. APHIS Form 702!M\ I B. Number of anirml

b m g MW. c~dlli-a. a held fw U M in teaming, tnling, expanmntr. research. a rurgay but not yr urea f a rum D " m 3 D n

C. N u m r d m m l 8 umn ~ h l m teachwg. mearch. e.pBnmn16.a tests w e mnduded m"mvmg no pal". dlslleu. or UY o p t n 4 i N l n g dm*

D. Nu* danimsis upon vhich smstimals, teaming, reaaarm ruw, w tests n r e conduma involving accOmpBnylng p m 0' dimus to he m i m i r en f0,unrich appcwste anrithelis. analgsslc, a ~mnquliimg dm* v m "red.

E. hm- ol an ms s reon m ch tcacnnw. expr -IS I F. rarurm i r g q w lasts a m una.nar ,nro r ng am-ny ng pan w mwesr to me an ma a and lor w vw rre ot s w a m . n e s ~ . mnpa.c a vanw I

'OrU hLMBER

amgs -10 nam aarvsay ~cna me -a,m rss OF AN MA.S

01 mtmmtsum d the t a m np, r-ru c ipernnt r ~ . rpv . or tests I h emanaton d ow emeo.rcs ( COLJMNS mwslng p m or d s u . ~ n MW anme r ano the maw c + D + E ) s m auos were nm .w m u , oc aumw IO mtr repon

Hamstem

Rabbits

Nmhumao Pnmalss

I I I 1 I Pigs

I I I I I

223

Sheep

( AUG $1 )

Wler Farm Animals

Goats Ofher Animals

NOV 1 2 2003

1

7

224

7

81 81

Th I vepoll 8s isgd lea by law I 7 U X 21431 fa1.m lo i s p l rcoldmy to she rwvU! ms ~ . n Ses r m r v oo. 10, 2303

In0a"yenry Rawl l L,,,,,"l NG rs,dl an an ovm, no cease and dsarl and to b. ruqact lo psomoss as povdw lor rl ~ l l o n 2150 . d d o l a a u l nnlornwwm 0180 W A AN

W n i D STATES DEPARTYEN1 OF MMCULNRE ANIMAL AND P U N l HEALTH INSPECMN SEWICE I FORM APPRWED

QLV--nn; I ANNUAL REPORT OF RESEARCH FACILITY I Departmeut of Veteransx Affairs Central Office

(TYPE OR PRINT) 810 Vermont Avenue, IW Washington, D.C. 20420 I

I I FACILITY LOCATK*(S l ~ l ( e s 1

VA Medical Center-6G2 I

San Francisco. CA 94121 IRERW(T OF ANIMUS USED BV OR UNDtR CONlROl 1

4. D ~ g s 0

5. Cats n 6. Guinea Pigs 0

7. Hamsters 0

8. Rabbtls 0

9. Non-human Primales 0

10, Shaap 0

1 1 . PiQS 0

12. Other Farm Animals 0

I ASSJRAhCE STATEMENTS

I, Plulr,, 0,.*1y acEe"IOb4e ,I.llddldJ QOrnlll l l" 111 U#W lul6w ily ~ L I V Y ~ r e ~ d r c h !eocnmo l n l q ,

I I FLClLW LOW.TlOm ISdes)

570 - VACCHCS Fresno CA

\ ''[SF ANNUAL REPORT OF RESEARCH FACILITY \" (TYPE OR PRINT)

VA Central California Health Care System 2615 E. Clinton Avenue Fresno CA 93703

CEK'PIFICA'I'ION RY I1EAl)QUAH'PEY REYEAKC11 I'ACII.ITY OI'FICIAI.

3. REPORTING FACILITY (LwI all loealions w l w s mama16 wars hovrsa ov urad rn r i w l cswarrh. Inlslg. I s r h m u , w e x p r l m a u l d l ~ & , ur held lor these pw-s A u x h a d d # t l ~ ~ ~ a ~ *eels ,I ,,we*%o,y 1

4. Dogs

5. C a t s

6. Guinea PIQS

7. Hamsters

8. f labk i ts

9. Non-human Pnmales

10. Sheep

11. PUS

12. Other F a r m Anlrnals

0

0

0

0

0

0

0

0 0

APHIS FORM 7023 Y l ~ e p l a c e o VS FORM 18-23 (OCT 813). whch is obsolele)

(AUG 91)

PART 1 - HFAnOl IARTFRS

DATE SIGNED

[I--3

Documents

USDA APHIS | Home Landing Page€¦ · 83-R-0028 1181 1 3. REPORTING FACILITY (LiU 31 1-bonr whas anlrnis wn, hwed wured in .dual nrursh, leNn0. leachhp, or uWnaOtim. held for !hue