SURGICAL SCRUB& HAND SANITIZERContains biofl avanoids as part of a clinically proven formulation

anoids cally onon

SURGICAL SCRUBA rapid acting biocidal antiseptic solution for pre-operative hand scrubbing and routine skin cleaning to reduce the risk of any cross infection.

For applying pre-operatively to disinfect skin surface at surgical site:

• Thoroughly clip and clean the area

• Apply undiluted to patient’s intact dry skin

• Rub into the skin and allow to dry

• Maximal effect within minutes

Pre-operative surgical hand disinfection routine:

• Wash hands and apply 5ml of undiluted scrub, wash for 1 minute

• Clean fi ngernails and scrub thoroughly for 1 minute

• Apply a further 5ml, wash and scrub for 3 minutes

• Rinse thoroughly and dry

Vetroxx Surgical Scrub is

• Clinically proven• Antimicrobial• Hypoallergenic • Dermatologically tested• Contains biofl avanoids • Non toxic

Vetroxx Surgical Scrub is completely safe and non toxic for both veterinary staff and patients1. It causes minimal irritancy to the skin2 and the mild formulation is suitable for repeated use for all skin types. Vetroxx Surgical Scrub is tested to BSEN1276, BSEN13704 and BSEN1275 standards under dirty conditions.

Rigorous pre-operative skin disinfection is essential to good surgical procedure in the veterinary practice.

Instructions for use

Vetroxx Surgical Scrub is an antimicrobial preparation for pre-operative surgical hand disinfection, routine antiseptic hand washing and pre-operative skin antisepsis for patients undergoing surgery.

Available in 5 litre &

500ml

HAND SANITIZERFor maintaining pathogen free hands and good hygiene for veterinary personnel throughout the working day.

Vetroxx Hand Sanitizer is

• Clinically proven• Antimicrobial• Alcohol free• Hypoallergenic• Dermatologically tested• Contains biofl avanoids• Non toxic

Vetroxx Hand Sanitizer is completely safe, alcohol free and kind to hands1. It is hypoallergenic, dermatologically tested and causes minimal irritancy to the skin2. The mild, alcohol free formulation is suitable for repeated use for all skin types throughout the working day, maintaining pathogen free hands without causing dryness or irritation. Vetroxx Hand Sanitizer is tested to BSEN1276, BSEN13704 and BSEN1275 standards under dirty conditions.

Hand disinfection:

• Thorough and regular hand disinfection is essential for infection control in the veterinary practice

• Hands should be disinfected before and after handling patients

• Use of a hand sanitizer alleviates the need for constant washing and drying

Instructions for use• Apply to clean hands and allow to dry naturally, repeat as often as required

Vetroxx Hand Sanitizer’s alcohol free mild formulation makes it suitable for sensitive skin.

Available in 500ml & 50ml

What is Vetroxx?• Vetroxx active is based on a novel approach

to antisepsis

• The active is based on the patented Citroxx technology

So what is Citroxx comprised of?• Citroxx is a patented combination of small and large

biofl avanoid molecules in combination with carefully selected fruit acids at certain ratios. The end product results in proven antimicrobial activity, via the biofl avanoid molecules enhancing/potentiating the activity of the fruit acids

• Biofl avanoids are derived from the natural defence mechanisms of citrus fruit, particularly in Vetroxx’s case Bitter Oranges (Citrus Aurantium)

• Fruit acids are produced from natural sources and are widely accepted as preservatives and antimicrobials in a wide range of industries

Properties of biofl avanoids• Polyphenolic compounds

• Produced naturally by plants

• Pigmentation

• Antioxidative

• Antimicrobial

• Skin conditioning properties

Biofl avanoid enhanced fruit acids and their mode of action against microbes• Enzyme inhibition

• Break surface-exposed adhesions

• Work on cell wall polypeptides

• Work on membrane bound enzymes

• Complexing with extra cellular and soluble proteins

• Disrupt microbial membranes

• Inactivate microbial adhesions, enzymes, cell envelope transport proteins

Fruit acid activity is enhanced by the addition of selected biofl avanoids• Activity enhanced by biofl avanoids from

the Bitter Orange

• Naringin and Neohesperidin especially enhance the activity

Ancillary roles of fruit acids in Citroxx• Removal of ions (for example insoluble metal ions such

as calcium, magnesium etc. present in hard water)

• Necessary control of pH - to control hydrogen ion activity

• Maintenance of the shelf life

• Provision of a fully solubilised liquid matrix with well defi ned physical properties

The Vetroxx active ingredient Citroxx has excellent antimicrobial effectiveness and has been tested under dirty conditions. Also, it is approved for use for disinfectant purposes by the Department of Health (UK) which indicates its potency. Citroxx active has also been used to decontaminate fresh produce in leading high street supermarkets which demonstrates its safety.

BacteriaAlternaria sp. Campylobacter jejuni Chaetomium golbosum Dipiodia natalensis Escherichia coli F. sp. tuberosa Fusarium sambucinum Geotrichum candidium Klebsiella pneumonia Lactobacillus pentoaceticus Legionella pneumophila (NCTC 11192)Listeria monocytogenes MRSA (clinical strain)Mycobacterium fortutium (NCTC 8573 for indication of tuberculocidal activity) Penicillium digitatum Penicillium funiculosum Penicillium italicum Penicillium roqueforti Penicillium sp. Phomopsis ortl Proteus vulgaris

Pseudomonas aeruginosa (ATCC 15442) Pullularia pullulans Salmonella chloreraesuis Salmonella typhimurium (DT004) Scerotinia laxa Staphylococcus aureus (NCTC 6571) Staphylococcus pyogenes Staphylococcus sp. Sterptococcus faecalis Trichophyton iterdigitale

VirusesHepatitis A + PH5N1 (Avian Infl uenza A)Human RhinovirusInfl uenza AHuman Immunodefi ciency Virus (HIV)Urbani SARSAfrican swine fever Foot & mouth disease Gumboro virus Herpes virus

Yeast and FungiAspergillus fl avus Aspergillus niger Aspergillus terreus Botrytis cinerea Candida albicans Candida glabrata Chaetonium globosum Cladosporium Collectotricum sp. Fusarium sp. Mucor sp. Penicillium sp. Pullularia pullulans Pythium sp. Trichophyton interdigitale Trichophyton mentagrophytes

ProtozoaHistomonas meleagradis Giardia lamblia Entamoeaba histolytica Blastocystis hominis

The Vetroxx active (Citroxx) has been widely tested and proven against a wide range of microbes including:

Comparison table of Vetroxx active against other commonly used actives

Active Agent Bactercide T.B. Sporicidal Virucidal Fungicide Applications Advantages Disadvantages

Citroxx Yes Yes Yes Yes Yes

Skin/handAir

SurfacesInstruments

BiodegradableFast actingNon toxicOrganic

None known

Alcohol Yes Yes No Yes Yes Skin/handFast actingDries fast

IrritationHighly fl ammableEvaporates easily

Phenols Yes Yes No Yes YesSurfaces

InstrumentsLow concentrate

required

ToxicLong application time

Produces odour

Oxidisingagents

Yes Yes Yes Yes YesWater

InstrumentsMucous membranes

BiodegradableFast acting

UnstableShort shelf life

Corrosive

Halogens Yes Yes Yes Yes YesHands

InstrumentsFast acting

High concentrationAllergic reactions

Irritations

Aldehydes Yes Yes Yes Yes YesSurfaces

InstrumentsBiodegradable

Low concentrate

ToxicBinds to proteinsProduces odour

Quaternaryammonia

compoundsPartly Yes No Partly Partly

SurfacesInstruments

Fast actingLow concentrateBiodegradable

High cleaning powerWell tolerated

Low spectrum of effectiveness

In conclusion the Vetroxx active Citroxx is clinically proven for a wide range of applications without any side effects.

Trial comparing active in Vetroxx Surgical Scrub vs. chlorhexidine formulations

Time taken for a 6-Log reduction in cell numbers following exposure to active in Vetroxx Surgical Scrub or 4% v/v chlorhexidine.

STRAIN STRAIN INFORMATION VETROXXSURGICAL SCRUB*

4% CHLORHEXIDINE

S. aureus BH1CC Hospital-Acquired (HA) MRSA 2 minutes 2 minutes

S. aureus USA300-Lac Community-Acquired (CA) MRSA 2 minutes 2 minutes

S. aureus NCTC8325-4 Laboratory strain 2 minutes 2 minutes

S. aureus 10/68 Bovine isolate 2 minutes 2 minutes

E. coli 0157 Food pathogen 3 minutes 4 minutes

*1% Citroxx.

Conclusion• Vetroxx Surgical Scrub is as effective as a chlorhexidine based scrub

• Vetroxx Surgical Scrub is effective against MRSA

• The active in Vetroxx Surgical Scrub is a proven potent antimicrobial substance

A clinically proven formulation of biofl avanoids combined with dermatological benefi ts for the patient and the vet makes Vetroxx Surgical Scrub the best choice of product for your practice.

Vetroxx Surgical Scrub and Vetroxx Hand Sanitizer are approved by DEFRA and the Irish Department of Agriculture, Food and Marine.Independently Tested in Certifi ed Laboratories under dirty conditions. Tested to BSEN1276, BSEN13704 and BSEN1275 standards.

References: 1a. Evaluation of the Health Aspects of Hesperidin, Naringin, and Citrus Biofl avanoid Extracts as Food Ingredients. 1b. Acute Dermal Toxicity Study in Rats - Limit Test. 1c. Acute Oral Toxicity Up and Down Procedure in Rats. 2a. Dermal Sensitization Study in Guinea Pigs (Buehler Method). 2b. Report on the determination of Acute Dermal Irritancy By Skin Patch Testing - 24hr patch test.

Further information is available from: Bimeda UK. Unit 2, Bryn Cefni Industrial Park, Llangefni, Anglesey LL77 7XA • T: 0800 526 769Bimeda Ireland. Broomhill Road, Tallaght, Dublin 24, Ireland • T: 00353 1451 5011 www.bimeda.com

“My colleagues and I at Athy Veterinary Hospital have used Vetroxx for a variety of surgical procedures including orthopaedic surgery. We found it highly effective and experienced no problems with the product.

Our staff commented on how effective and gentle it was even on sensitive skin and hands. I would highly recommend the product to other practices.”Andrew Doona MVB Cert(SAS), MRCVS, Partner, Athy Veterinary Hospital.

“All of the work we have done to date in my laboratory with the active ingredient of Vetroxx Surgical Scrub indicates that it has fantastic antimicrobial activity against a range of pathogenic bacteria.”

Dr James P. O’Gara, Senior Lecturer and Conway Fellow, Head of Graduate Studies, School of Biomolecular and Biomedical Science, UCD.

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