INDEX

325

Volume 171, January-February 1970

Adenosine triphosphatase, Na�,K�-stimWated,activity of, after treatment with strophan-

thidin-3-bromoacetate, 13

Na+, K+�Adenosine triphosphatase, cardiac re-laxing system, mitochondria and, isolationfrom canine myocardium, influence of oua-bain on, 1

Adipose tissues, isolated, lipolysis in, inhibitionby sulfhydryl reagents, 135

Adrenergic nerves, in rabbit aortic stripe, kinetic

and thermodynamic considerations regardinginhibition by tricyclic antidepressants ofuptake of tritiated norepinephrine by, 62

Aghajanian, G. K., Foote, W. E. and Sheard,M. H. : Action of psychotogenic drugs onsingle midbrain raphe neurons, 178

Alanine, subcellular localization in rat cerebralcortical slices, 141

Alcohol, ethyl, effects on temporally spaced

responding in humans, 159Allen, J. C., see Beach, H. R., Jr., 1H-Amino acids, subcellular localization in rat

cerebral cortical slices, 141p-Aminohippurate, (PAH), penicillin and, sub-

strate stimulation by, maturation of renalorganic acid transport, 103

Aminopyrine, hepatic metabolism in neonataland adult rat, influence of diphenylhydantoinon, 127

Amphetamine, mechanisms for inhibition ofoxidative dearnination of norepinephrine inbrain by, 188

d-Amphetamine, effect on operant behavior inrats, 166

Anagnoste, B., see Goldstein, M., 196Anaphylaxis, reduction of tissue uptake of circu-

lating H’-histamine in, 88Anderson, D., see Roth-Schechter, B. F., 24.9Anesthetics

local, site of action and active form of, experi-ments with quaternary compounds, 45

local, site of action and active form of, theoryand pH experiments with tertiary com-pounds, 32

Aniline hydroxylase, hepatic metabolism inneonatal and adult rat, influence of diphenyl-hydantoin on, 127

Anophthalmia, effect of dibutoxyethyl phthalatein developing chick embryo, 314

Antagonists, cholinergic, effects of nicotine onfixed-interval behavior and their modifica-tion by, 166

Antidepressants, tricyclic, of uptake of tritiated

norepinephrine by adrenergic nerves in

rabbit aortic strips, kinetic and thermody-namic considerations regarding inhibition by,

62Aorta

atrium, stomach, trachea and, of rabbit, analy-sis of beta receptor drug interactions in, 52

strips, effects of glyceryl trinitrate on, 98strips, rabbit, kinetic and thermodynamic

considerations regarding inhibition by tn-cyclic antidepressants of uptake of tnitiatednorepinephnine by adrenergic nerves in, 62

Arginine, subcellular localization in rat cerebralcortical slices, 141

Artery, pulmonary, rabbit, influence of sym-pathetic nerve stimulation on conversion of

H-tyroaine to H’-catecholamine and onH-norepinephnine disposition in, 214

Atnia, rabbit, effects of ouabain after pretreat-ment with strophanthidin-3-bromoacetate, 13

Atnial muscle, effect of tetrodotoxin on trans-membrane potential of, 20

Atrium, aorta, stomach, trachea and, of rabbit,analysis of beta receptor drug interactions in,52

Atropineaction on single midbrain raphe neurons, 178

effect on heart rate changes induced by cloni-dine, 256

Axon(s)

effect of germine-3-acetate on electrical activityin cat soleus nerves, 223

membranes, squid, blocking potency of lido-caine derivatives on, 32

membranes, squid, effect of lidocaine deniva-tives and hemicholinium-3 on block of actionpotential of, 45

Ay 21,011, beta blocking effects in isolated rabbitatrium, aorta and trachea, 52

Bakay, B. and Nyhan, W. L. : Effects of thalido-mide and chlorcyclizine on the biosynthesisof nucleic acids and proteins in fetal andmaternal tissues of the rat, 109

Barker, W. M., Hermodson, M. A. and Link,K. P. : The metabolism of 4-C14-warfaninsodium by the rat, �7

Baroreceptor denervation, effect on heart ratechanges induced by clonidine, 256

Baum, T., Shropehire, A. T., Rowles, G., VanPelt, R., Fernandez, S. P., Eckfeld, D. K. and

326 INDEX

Gluckman, M. I. : General pharmacologic ac-tions of the antihypertensive agent 2,6-dichlorobenzylidene aminoguanidine acetate(Wy-8678), 276

Becker, B. A., see Eling, T. E., 127

Behavior

effects of ethyl alcohol on temporally spaced

responding in humans, 159

fixed-interval, effects of nicotine on, modifica-tion by cholinergic antagonists, 166

Benzhydrylpiperazine compounds, teratogenic

effects in rat embryos, 118Benzphetamine, hepatic metabolism in neonatal

and adult rat, influence of diphenylhydantoinon, 127

Benzpyrene hydroxylase, hepatic metabolism inneonatal and adult rat, influence of diphenyl-

hydantoin on, 127

Beach, H. R., Jr., Allen, J. C., Glick, G. andSchwartz, A. : Correlation between the mo-

tropic action of ouabain and its effects on

subcellular enzyme systems from caninemyocardium, 1

Beta receptor, drug interactions in isolated rabbitatrium, aorta, stomach and trachea, analysisof, 52

Biosynthesis, of nucleic acids and proteins in

fetal and maternal tissues of rat, effects ofthalidomide and chlorcyclizine on, 109

Blocking potency, of lidocaine derivatives, 6211and 6603, theory and pH experiments with, 32

Bloodflow, coronary, calcium exchangeability, myo-

cardial function, high energy phosphate stores

and, effect of glucagon on, 265flows, renal and limb, in conscious dog, differen-

tial effect of furosemide on, 300pressure, effect of clonidine on, 256

pressure, effect of Wy-8678 on, 276Bloom, F. E., see Stjfirne, L., 70Boukma, S. J., see Johnson, G. A., 80Bower, R. K., Haberman, S. and Minton, P. D.:

Teratogenic effects in the chick embryo

caused by esters of phthalic acid, 314Brain

effect of in vivo inhibition of dopamine $-hy-droxylase by 1-phenyl-3-(2-thiazolyl)-2-thio-urea (U-14,624) on norepinephrine in, 80

mechanisms by which amphetamine inhibitsoxidative deamination of norepinephrine in,188

rat, regional distribution and metabolism ofH-tyramine in, 196

subcellular localization of amino acids in ratcerebral cortical slices, 141

Bristow, M., Sherrod, T. R. and Green, R. D.:

Analysis of beta receptor drug interactions inisolated rabbit atrium, aorta, stomach and

trachea, 52

Brody, M. J., see Ludens, J. H., 3002-Brom-LSD, action on single midbrain raphe

neurons, 178

Bromoacetates, alkylating, of strophanthidin and

strophanthidol-[19-H’], on the positive mo-

tropic action of, 13

Caffeine

dextroamphetamine and, toxicity in mice,

effect of environmental temperature on, 153effect on ryanodine-depressed skeletal muscle,

242

Calciumbinding and uptake by cardiac relaxing system

and accumulation and oxidative phosphoryla-

tion by mitochondria in canine myocardium,influence of ouabain on, 1

exchangeability, coronary blood flow, myo-cardial function, high energy phosphate storesand, effect of glucagon on, 265

Calcium”, movements, quinine contractures and,of frog sartonius muscles, effect of pH on, 26

Calvert, D. N. and Lech, J. J. : Inhibition oflipolysis in isolated fat cells by sulfhydryl

reagents, 135Cardiac contractions, effect on binding of digoxin,

249Cardiac relaxing system, Na+,K+�adenosine tn-

phosphatase, mitochondnia and, isolation

from canine myocardium, influence of oua-bain on, 1

Carotid sinus denervation, effect on heart ratechanges induced by clonidine, 256

Carson, V., see Nayler, W. G., 265Cartilage, binding, in vitro, norchlorcyclizine

analogs and relationship of tenatogenicactivity to, 118

Catabolism, distribution and, of circulatingH’-histamine in female rat, 88

Catecholamine, deamination in brain cortex, 188H’-Catecholamine, conversion of H’-tyrosine to,

influence of sympathetic nerve stimulation onH1-norepinephrine disposition and, in rabbit

pulmonary artery, 214

Cell(s)fat, isolated, lipolysis in, inhibition by suif-

hydryl reagents, 135nonmast-, histamine kinetics, 88

Central nervous system, effect of esters of phthalicacid on embryologic development in chick, 314

Cerebral cortical slices, rat, subcellular distribu-tion of free H-glutamic acid in, 141

Chipperfield, D., see Nayler, W. G., 265Chlorbenzhydrol, inactivity as a teratogenic

agent in rat embryos, 118

Chlorbenzylpiperazine, inactivity as a teratogenicagent in rat embryos, 118

Chlorcyclizine

INDEX 327

teratogenic effects in rat embryos, 118thalidomide and, effects on biosynthesis of

nucleic acids and proteins in fetal and ma-ternal tissues of rat, 109

Chlorcyclizine-N-oxide, inactivity as a terato-

genic agent in rat embryos, 118Chlorcyclizine-N-tert.-butyl, teratogenic effects

in rat embryos, 118p-Chloromercuribenzoate, inhibition of norepi-

nephrine-stimulated lipolysis in isolated fat

cells by, 135Chiorpromazine, action on single midbrain raphe

neurons, 178Chioruresis, acute effects of mefruside in man, 288Cholinergic antagonists, effects of nicotine on

fixed-interval behavior and their modification

by, 166Clonidine, (ST-155), cardiac slowing effects in

dogs, 256Contractures, quinine, Ca” movements and, of

frog sartonius muscles, effect of pH on, 26Cornea, embryologic development in chick, effect

of esters of phthalic acid on, 314Coronary blood flow, calcium exchangeability,

myocardial function, high energy phosphatestores and, effect of glucagon on, 265

Cortexslices, cerebral, rat, subcellular distribution of

free H’-glutamic acid in, 141tissue slices, brain, mechanisms by which

amphetamine inhibits oxidative deaminationof norepinephnine in, 188

Crania bifida, effect of dibutoxyethyl phthalatein developing chick embryo, 314

Cyclizine, teratogenic effects in rat embryos, 118

Cytochrome b6 , hepatic metabolism in neonataland adult rat, influence of diphenyihydantoinon, 127

Cytochrome P450, hepatic metabolism in neo-natal and adult rat, influence of diphenyl-hydantoin on, 127

Daile, P., see Nayler, W. G., 265Dehydration, environmental temperature and, ef-

fects on toxicity of caffeine and dextroam-

phetamine in mice, 153

Desipramine, effect on norepinephnine uptake insympathetic nerve trunks, 70

Desmethylimipramine, uptake of tritiated norepi-

nephrine by adrenergic nerves in rabbit aortic

strips, inhibition by, 62Detwiler, P. B., see Standaert, F. G., 223

Dextroamphetamine, caffeine and, toxicity inmice, effect of environmental temperature on,

153Di-2-methoxyethyl phthalate, teratogenic proper-

ties in developing chick embryo, 314

Dibutoxyethyl phthalate, teratogenic propertiesin developing chick embryo, 314

2, 6-Dichlorobenzylidene aminoguanidine acetate,(Wy-8678), antihypertensive agent, general

pharmacologic actions of, 276Digoxin, relationship among contraction, drug

binding and positive inotropic action of, 2492,5-Dimethoxy-4-methylamphetamine, action on

single midbrain raphe neurons, 178N,N-Dimethyltryptamine, action on single mid-

brain raphe neurons, 178Diphenyihydantoin, effect on neonatal and adult

rat hepatic drug metabolism, 127Disulfiram, inhibition of dopamine-�-hydroxylase

in rat brain by, 196Diuretics, acute effects of mefruside in man, 288

Domino, E. F., see Stitzer, M., 166

H’-Dopamine, influence of electrical stimulationof sympathetic nerves on conversion of H-

tyrosine to, 214Dopamine-�-hydroxylase

inhibition by disulfiram in rat brain, 196in vivo inhibition of, by 1-phenyl-3-(2-thia-

zolyl)-2-thiourea (U-14,624), 80

Eckfeld, D. K., see Baum, T., 276Eckhardt, S. B., see Maxwell, R. A., 62Eling, T. E., Harbison, R. D., Becker, B. A. and

Fouts, J. R. : Diphenylhydantoin effect on

neonatal and adult rat hepatic drug metabo-lism, 127

Embryo(s)chick, teratogenic effects caused by esters of

phthalic acid, 314

rat, relationship of teratogenic activity of nor-chlorcyclizine analogs to in vitro cartilagebinding, 118

Enzyme systems, subcellular, from canine myo-cardium, correlation between inotropic actionof ouabain and its effects on, 1

Ephedrine, related compounds and, mydriasis,analysis in relationship to iris pigmentation

in guinea-pig eye in vitro, 205Epinephrine, effect on ryanodine-depressed skele-

tal muscle, 242

Esters, of phthalic acid, teratogenic effects inchick embryo caused by, 314

Ethyl alcohol, effects on temporally spacedresponding in humans, 159

N-Ethylmaleimide, inhibition of norepinephrine-stimulated lipolysis in isolated fat cells by, 135

Eyeeffect of esters of phthalic acid on embryologic

development of cornea in chick, 314

guinea-pig, in vitro, analysis of ephedrine

mydriasis in relationship to iris pigmentation

in, 205

328 INDEX

Katz, N. L., Ingenito, A. and Procita, L.: Ryano-

Fat cells, isolated, lipolysis in, inhibition bysulfhydryl reagents, 135

Felch, W. C., Jr., see Goldstein, M., 196

Fernandez, S. P., see Baum, T., 276Foote, W. E., see Aghajanian, G. K., 178Fouts, J. R., see Eling, T. E., 127Frazier, D. T., Narahashi, T. and Yamada, M.:

The site of action and active form of localanesthetics. II. Experiments with quaternarycompounds, 45

Frazier, D. T., see Narahashi, T., 32Furosemide, differential effect on renal and limb

blood flows in conscious dog, 300

Germine-3-acetate, germine-3, 16-diacetate and,neuromuscular pharmacology of, 223

Germine-3, 16-diacetate, germine-3-acetate and,neuromuscular pharmacology of, 223

Giarman, N. J., see Stj#{228}rne, L., 70Gills, C. N., see Kupferman, A., 214Glick, G., see Besch, H. R., Jr., 1Glucagon, effect on calcium exchangeability,

coronary blood flow, myocardial function andhigh energy phosphate stores, 265

Gluckman, M. I., see Baum, T., 276

H�-Glutarnic acid, free, subcellular distributionin rat cerebral cortical slices, 141

Glyceryl trinitrate, tolerance to vascular effectsof, 98

Olycine, subcellular localization in rat cerebralcortical slices, 141

Glycoside, effect of myocardial contractions on,249

Goldstein, M., Anagnoste, B., Yamamoto, A. and

Felch, W. C., Jr. : Regional distribution andmetabolism of H’-tyramine in the rat brain,196

Green, R. D., see Bristow, M., 52

H 35/25, beta blocking effects in isolated rabbitatrium, aorta, stomach and trachea, 52

Haberman, S., see Bower, R. K., 314Harbison, R. D., see Eling, T. E., 127Heart

canine, correlation between inotropic action ofouabain and its effects on subcellular enzymesystems from, 1

canine, positive inotropic effect of glucagon in,265

effect of tetrodotoxin on tranamembrane poten-tial of, 20

inotropic action of digoxin and relationship todrug binding, 249

rate changes, effect of clonidine on, 256rate, effect of Wy-8678 on, 276

Heitz, D. C., see Ludens, 3. H., 300Hemicholinium-3, effects on action potential of

nerve membranes, 45

Hermodson, M. A., see Barker, W. M., 307Hexamethonium

effect on cardiovascular effects of Wy-8678, 276effect on operant behavior in rats, 166

Hexobarbital, hepatic metabolism in neonataland adult rat, influence of diphenyihydantoinon, 127

Hirsch, G. H. and Hook, J. B. : Maturation ofrenal organic acid transport: Substratestimulationbypenicillin andp-aminohippurate(PAll), 103

Histamine kinetics, nonmast-cell, distributionand metabolism in female rat, 88

Histidine, subcellular localization in rat cerebralcortical slices, 141

Histidine decarboxylase, influence on disap-

pearance of Ha-histamine from tissues infemale rat, 88

Bite, G., see Maxwell, R. A., 62

Holland, W. C., see Yanaga, T., 20Homochiorcyclizine, teratogenic effects in rat

embryos, 118Hook, J. B., see Hirsch, G. H., 103H’-p-Hydroxyphenylacetic acid, metabolite of

tyramine in rat brain, 196H-p-Hydroxyphenylethanol, metabolite of tyra-

mine in rat brain, 196Hypothalamus, concentration of tyramine after

intraventricular injection, 196

Imipramine, uptake of tritiated norepinephrine

by adrenergic nerves in rabbit aortic strips,inhibition by, 62

Ingenito, A., see Katz, N. L., 242lodoacetamide, inhibition of norepinephrine-

stimulated lipolysis in isolated fat cells by, 135Iodoacetic acid, inhibition of norepinephrine-

stimulated lipolysis in isolated fat cells by, 135Iris, pigmentation, in guinea-pig eye in vitro,

analysis of ephedrine mydriasis in relation-ship to, 205

Iaaaeson, A., Yamaji, K. and Sandow, A. : Quinine

contractures and Ca” movements of frog

sartorius muscles as affected by pH, 26

Isoproterenol, effect of clonidine on increased

heart rate produced by, 256

Johnson, G. A., Boukma, S. J. and Kim, E. G.: In

vivo inhibition of dopamine ,9-hydroxylase by1 - phenyl -3- (2- thiazolyl) -2 - thiourea (U -

14,624), 80Johnson, H. L.: Nonmast-cell histamine kinetics.

III. Uptake, metabolism and decline of H-histamine in the female rat and effects of

endogenous histamine release, 88

INDEX 329

dine-induced contractile failure of skeletal

muscle, 242

Kidneydiuretic effects of mefruside in man, 288

limb and, blood flows in conscious dog, differ-ential effect of furosemide on, 300

organic acid transport during maturation, 103Kim, E. G., see Johnson, G. A., 80King, C. T. G., see Wilk, A. L., 118Kirkendall, W. M., see Wilson, C. B., 288

Kuhar, M. J. and Snyder, S. H. : The subcellular

distribution of free H’-glutamic acid in ratcerebral cortical slices, 141

Kupferman, A., Gillis, C. N. and Roth, R. H.:

Influence of sympathetic nerve stimulation

on conversion of H’-tyrosine to H’-catechola-mine and on H’-norepinephrine disposition inrabbit pulmonary artery, 214

Lech,J.J.,seeCalvert,D.N., 135Lidocaine

derivatives, QX-314 and QX-572, effects onaction potential of nerve membranes, 45

derivatives, 6211 and 6603, theory and pH

experiments with, 32Link, K. P., see Barker, W. M., 307Lipolysis, in isolated fat cells, inhibition by suif-

hydryl reagents, 135

Liver, neonatal and adult rat, drug metabolismin, effect of diphenylhydantoin on, 127

LSD (D-lysergic acid diethylamide), action onsingle midbrain raphe neurons, 178

Ludens, J. H., Heitz, D. C., Brody, M. J. andWilliamson, H. E. : Differential effect offurosemide on renal and limb blood flows inthe conscious dog, 300

D-Lyserglc acid diethylamide (LSD), action onsingle midbrain raphe neurons, 178

Lysine, subcellular localization in rat cerebralcortical slices, 141

Manganeseantagonist effect on inotropic action of glu-

cagon, 265effect of tetrodotoxin on tranamembrane poten-

tial of atrial muscle modified by, 20Maxwell, R. A., Eckhardt, S. B. and Hite, G.:

Kinetic and thermodynamic considerationsregarding the inhibition by tricycic antide-preasants of the uptake of tritiated norepi-nephrine by the adrenergic nerves in rabbit

aortic strips, 62Mclnnes, I., see Nayler, W. G., 265McMillan, D. E.: The effects of ethyl alcohol on

temporally spaced responding in humans, 159McN A-343, ganglionic stimulation with, effect on

changes in heart rate produced by clonidine,

256

Mecamylamine, effect on operant behavior in rats,

166

Mefruside, a new diuretic compound, acute

effects in man, 288Membranes

axon, squid, blocking potency of lidocainederivatives on, 32

axon, squid, effect of lidocaine derivatives andhemicholinium-3 on block of action potentialof, 45

Mescaline, action on single midbrain rapheneurons, 178

Metabolismdistribution and, of circulating H’-histamine in

female rat, 88drug, hepatic, neonatal and adult rat, effect of

diphenylhydantoin on, 127

of 4-C14-warfarin sodium by rat, 307regional distribution and, of H’-tyraznine in rat

brain, 196Methylcyclizine, teratogenic effects in rat em-

bryos, 118N-Methylnicotinamide, transport in kidney dur-

ing maturation, effects of p-aminohippurate(PAH) and penicillin on, 103

Microsomes, heart, effect of glucagon on Ca�uptake and displacement in, 265

Midbrain raphe neurons, single, action of pay-

chotogenic drugs on, 178Minton, P. D., see Bower, R. K., 314

Mitochondria

Nat, K�-adenosine triphosphatase, cardiac re-

lazing system and, isolation from caninemyocardium, influence of ouabain on, 1

heart, effect of glucagon on Ca� uptake anddisplacement in, 265

inhibition of monoamine oxidase by ampheta-mine in, 188

Monoamine oxidase, inhibition by amphetamine

in brain cortex and isolated synaptosomes, 188Morrison, J., see Stitzer, M., 166

Muller, P. J. and Vernikos-Danellis, 3. : Effect of

environmental temperature on the toxicityof caffeine and dextroamphetamine in mice,153

Muscle(s)atrial, effect of tetrodotoxin on tranamembrane

potential of, 20heart, binding of digoxin to, 249sartorius, frog, quinine contracturea and Ca4’

movements of, effect of pH on, 26skeletal, ryanodine-induced contractile failure

of, 242

smooth, influence of electrical stimulation ofsympathetic nerves on conversion of H’-tyrosine to H’-dopamine and H’-norepineph-rine subcellular distribution in rabbit pal-

monary artery, 214

330 INDEX

smooth, vascular, effects of glyceryl trinitrateon, 98

smooth, vascular, lack of direct effect of furo-

semide on, 300

soleus, cat, nerves and, effect of germine-3-acetate and germine-3 , 16-diacetate on, 223

Myasthenia gravis, mechanism of action ofgermine-3-acetate and germine-3, 16-diace-tate, 223

Mydriasis, ephedrine, in relationship to irispigmentation in guinea-pig eye in vitro,analysis of, 205

Myocardium, canine, correlation between mo-tropic action of ouabain and its effects on sub-

cellular enzyme systems from, 1

Narahashi, T., Frazier, D. T. and Yamada, M.:The site of action and active form of localanesthetics. I. Theory and pH experimentswith tertiary compounds, 32

Narahashi, T., see Frazier, D. T., 45Natriuresis, acute effects of mefruside in man, 288

Nayler, W. G., Mclnnes, I., Chipperfield, D.,Carson, V. and Daile, P. : The effect of glu-cagon on calcium exchangeability, coronaryblood flow, myocardial function and highenergy phosphate stores, 265

Needleman, P. : Tolerance to the vascular effectsof glyceryl trinitrate, 98

Nephrectomy, effect on decrease in limb bloodflow produced by furosemide, 300

Nerve(s)adrenergic, in rabbit aortic strips, kinetic and

thermodynamic considerations regarding in-hibition by tricycic antidepressants of uptakeof tritiated norepinephrine by, 62

soleus, cat, muscles and, effect of germine-3-acetate and germine-3,16-diacetate on, 223

sympathetic, cardiac, effect of clonidine oncardiac acceleration induced by stimulation

of, 256

sympathetic, stimulation, effect of Wy-8678 on,276

sympathetic, stimulation, influence on conver-sion of H’-tyrosine to H’-catecholamine and

on H’-norepinephrine disposition in rabbitpulmonary artery, 214

sympathetic, trunks, norepinephrine concen-trating mechanisms in, 70

Nervous system, central, effect of esters ofphthalic acid on embryologic development inchick, 314

Neuromuscular junction, effects of germ.ine-3-acetate and germine-3, 16-diacetate, 223

Neurons, raphe, midbrain, single, action ofpsychotogenic drugs on, 178

Nicotine, effects on fixed-interval behavior andmodification by cholinergic antagonists, 166

p-Nitroanisole, hepatic metabolism in neonataland adult rat, influence of diphenylhydantoinon, 127

p-Nitrobenzoic acid, hepatic metabolism in

neonatal and adult rat, influence of diphenyl-

hydantoin on, 127Norchlorcyclizine, analogs, relationship of terato-

genic activity to in vitro cartilage binding, 118Norcyclizine, teratogenic effects in rat embryos,

118Norepinephrine

concentrating mechanisms in sympatheticnerve trunks, 70

effect of Wy-8678 on cardiovascular responses

to, 276in brain, effect of in vivo inhibition of dopamine

j�-hydroxylase by 1-phenyl-3-(2-thiazolyl)-2-thiourea (U-14,624) on, 80

in brain, mechanisms by which amphetamineinhibits oxidative deamination of, 188

-stimulated lipolysis in isolated fat cells, in�hibition by sulfhydryl reagents, 135

tritiated, inhibition by tricyclic antidepressant&

of uptake of, by adrenergic nerves in rabbit.aortic strips, kinetic and thermodynamie

considerations, 62

C14-Norepinephrine, subcellular localization inrat cerebral cortical slices, 141

H’-Norepinephrine, disposition in rabbit pal-monary artery, influence of sympatheticnerve stimulation on conversion of H’-tyro-sine to H-catecholamine and on, 214

Norhomochlorcyclizine, teratogenic effects in rat

embryos, 118Normethylcyclizine, teratogenic effects in rat

embryos, 118Nortriptyline, uptake of tritiated norepinephrine

by adrenergic nerves in rabbit aortic strips,inhibition by, 62

Nucleic acids, proteins and, in fetal and maternaltissues of rat, effects of thalidomide and

chiorcyclizine on biosynthesis of, 109

Nyhan, W. L., see Bakay, B., 109

H’-Octopamine, content in rat brain after injec-

tion of tyramine, 196

Octyl isodecyl phthalate, teratogenic properties

in developing chick embryo, 314

Okita, G. T., see Roth-Schechter, B. F., 13, 249

Operant behavior, effects of nicotine on, modifica-tion by cholinergic antagonists, 166

Organic acid transport, renal, maturation of,

substrate stimulation by penicillin and

p-aminohippurate (PAll), 103

Orithine, subcellular localization in rat cerebralcortical slices, 141

Ouabain

INDEX 331

effects after pretreatment of rabbit atria withstrophanthidin-3-bromoacetate, 13

inotropic action and effects on subcellular en-zyme systems from canine myocardium,correlation between, 1

Oxidative deamination, of norepinephrine in

brain, mechanisms by which amphetamineinhibits, 188

Oxidative phosphorylation, by mitochondria incanine myocardium, influence of ouabain on, 1

Oxygen consumption, cardiac, of dog, effect of

glucagon on, 265

PAll, (p-aminohippurate), penicillin and, sub-strate stimulation by, maturation of renal

organic acid transport, 103Patil, P. N., see Seidehamel, R. J., 205Penicillin, p-aminohippurate (PAll) and, sub-

strate stimulation by, maturation of renalorganic acid transport, 103

Pentoliium, effect on renal and limb blood flowchanges produced by furosemide in consciousdog, 300

pH

effect on quinine contractures and Ca4 move-ments of frog sartorius muscles, 26

experiments, theory and, with tertiary com-pounds, site of action and active form of localanesthetics, 32

Phencyclidine, action on single midbrain rapheneurons, 178

Phenethylamine, derivatives of, action on singlemidbrain raphe neurons, 178

Phenoxybenzamine, effect on cardiovascular ac-tions, 276

Phentolamine

effect of Wy-8678 on cardiovascular effects of,276

influence on mydriasis produced by ephedrine

and related compounds in guinea-pig eye, 205

1-Phenyl-3-(2-thiazolyl)-2-thiourea, (U-14,624), in

vivo inhibition of dopamine �-hydroxylase by,

80Phosphate stores, high energy, calcium exchange-

ability, coronary blood flow, myocardial func-

tion and, effect of glucagon on, 265Phthalic acid, esters of, teratogenic effects in

chick embryo caused by, 314Piperazine, inactivity as a teratogenic agent in

rat embryos, 118

Procita, L., see Katz, N. L., 242

Propranolol

beta blocking effects in isolated rabbit atrium,

aorta, stomach and trachea, 52influence on mydriasis produced by ephedrine

and related compounds in guinea-pig eye, 205

Proteins, nucleic acids and, in fetal and maternal

tissues of rat, effects of thalidomide andchlorcyclizine on biosynthesis of, 109

Psychotogeic drugs, action on single midbrainraphe neurons, 178

Pulmonary artery, rabbit, influence of sympa-thetic nerve stimulation on conversion ofH’-tyrosine to H’-catecholamine and on H’-norepinephrine disposition in, 214

Quaternary compounds, experiments with, site of

action and active form of local anesthetics, 45Quinidine, effect on ryanodine-depressed skeletal

muscle, 242Quinine contractures, Ca” movements and, of

frog sartorius muscles, effect of pH on, 26Quinterenol, beta blocking effects in isolated rabbit

atrium, 52

Raphe neurons, midbrain, single, action of pay-chotogenic drugs on, 178

Receptor, beta, drug interactions in isolated rabbitatrium, aorta, stomach and trachea, analysis

of, 52Reserpine

effect on cardiovascular actions of Wy-8678, 276effect on norepinephrine uptake in sympathetic

nerve trunks, 70

pretreatment, nonmast-cell histamine releaseby, effect on catabolism and tissue uptake ofcirculating H’-histamine in female rat, 88

Richardson, F. F., see Roth-Schechter, B. F., 13,

249Roth, R. H.

see Kupferman, A., 214see Stjflrne, L., 70

Roth-Schechter, B. F., Okita, G. T., Anderson,D. and Richardson, F. : Relationship among

contraction, drug binding and positive mo-tropic action of digoxin, 249

Roth-Schechter, B. F., Okita, G. T., Thomas,R. E. and Richardson, F. F. : On the positiveinotropic action of alkylating bromoacetatea

of strophanthidin and strophanthidol-[19-H’J,13

Rowles, G., see Baum, T., 276

Rutledge, C. 0. : The mechanisms by which am-phetamine inhibits oxidative deamination ofnorepinephrine in brain, 188

Ryanodine-induced contractile failure of skeletal

muscle, 242

Sandow, A., see Isaacson, A., 26

Sartorius muscles, frog, quinine contractures andCa4’ movements of, effect of pH on, 26

Schedule-controlled behavior, effects of nicotineon, modification by cholinergic antagonists,166

Schwartz, A., see Besch, H. R., Jr., 1

332 INDEX

Scopolamine, action on single midbrain rapheneurons, 178

Scriabine, A., Stavorski, J., Wenger, H. C., Tor-

chiana, M. L. and Stone, C. A. : Cardiac slow-ing effects of clonidine (ST-155) in dogs, 256

Seidehamel, R. J., Tye, A. and Patil, P. N. : Ananalysis of ephedrine mydriasis in relationship

to iris pigmentation in the guinea-pig eyein vitro, 205

Serine, subcellular localization in rat cerebralcortical slices, 141

Sheard, M. H., see Aghajanian, G. K., 178

Sherrod, T. R., see Bristow, M., 52Shropahire, A. T., see Baum, T., 276

Skeletal muscle, ryanodine-induced contractilefailure of, 242

Smooth muscleinfluence of electrical stimulation of sympa-

thetic nerves on conversion of H’-tyrosine toH’-dopamine and H’-norepinephrine sub-cellular distribution in rabbit pulmonaryartery, 214

vascular, effects of glyceryl triitrate on, 98vascular, lack of direct effect of furosemide on,

300Snyder, S. H., see Kuhar, M. J., 141Sodium, effect on norepinephrine uptake in sympa-

thetic nerve trunks, 70Soleus nerves, cat, muscles and, effect of germine-

3-acetate and germine-3,16-diacetate on, 223Spinal cord section, effect on heart rate changes

induced by clonidine, 256ST-lbS (clonidine), cardiac slowing effects in

dogs, 256

Standaert, F. 0. and Detwiler, P. B. : The neuro-muscular pharmacology of germine-3-acetateand germine-3, 16-diacetate, 223

Stavorski, 3., see Scriabine, A., 256Steffek, A. J., see Wilk, A. L., 118Stitzer, M., Morrison, J. and Domino, E. F.:

Effects of nicotine on fixed-interval behavior

and their modification by cholinergic antag-onists, 166

StjArne, L., Roth, R. H., Bloom, F. E. and Giar-man, N. J.: Norepinephrine concentratingmechanisms in sympathetic nerve trunks, 70

Stomachatrium, aorta, trachea and, of rabbit, analysis of

beta receptor drug interactions in, 52pyloric, of female rat, decline of histamine

from, 88

Stone, C. A., see Scriabine, A., 256Strophanthidin, strophanthidol-[19-H’J and, on

the positive inotropic action of alkylatingbromoacetates of, 13

Strophanthidol-[19-H’], strophanthidin and, onthe positive inotropic action of alkylatingbromoacetates of, 13

Subcellular enzyme systems, from canine myo-cardium, correlation between inotropic actionof ouabain and its effects on, 1

Sulfhydryl reagents, inhibition of lipolysis in iso-lated fat cells by, 135

Sympathetic nerve(s)

cardiac, effect of clonidine on cardiac accelera-tion induced by stimulation of, 256

stimulation, effect of Wy-8678 on, 276stimulation, influence on conversion of H’-

tyrosine to H’-catecholamine and on H’-norepinephrine disposition in rabbit pul-

monary artery, 214trunks, norepinephrine concentrating mach-

anisms in, 70Synaptosomes

isolated, inhibition of monoamine oxidase byamphetamine in brain cortex and, 188

localization of amino acids in, 141

Temperature, environmental, effect on toxicity ofcaffeine and dextroamphetamine in mice, 153

Teratogensnorchlorcyclizine analogs, relationship of as-

tivity to in vitro cartilage binding, 118thalidomide and chlorcyclizine, effects on bio-

synthesis of nucleic acids and proteins in fetaland maternal tissues of rat, 109

Tertiary compounds, theory and pH experimentswith, site of action and active form of localanesthetics, 32

Tetrodotoxin, effect on transmembrane potentialof atrial muscle, 20

Thalidomide, chlorcyclizine and, effects on bio-

synthesis of nucleic acids and proteins in fetaland maternal tissues of rat, 109

Thomas, R. E., see Roth-Schechter, B. F., 13Threonine, subcellular localization in rat cerebral

cortical slices, 141Tibialis anticus, effect of ryanodine on, 242Tissue(s)

adipose, isolated, lipolysis in, inhibition bysulfhydryl reagents, 135

female rat, distribution and metabolism of H’-histamine in, 88

fetal and maternal, of rat, effects of thalidomideand chlorcyclizine on biosynthesis of nucleicacids and proteins in, 109

slices, cortex, brain, mechanisms by whichamphetamine inhibits oxidative deamination

of norepinephrine in, 188Torchiana, M. L., see Scriabine, A., 256

Toxicity, of caffeine and dextroamphetamine in

mice, effect of environmental temperature on,153

Trachea, atrium, aorta, stomach and, of rabbit,analysis of beta receptor drug interactions in,52

INDEX 333

Transmembrane potential, of atrial muscle, effect

of tetrodotoxin on, 20Tricyclic antidepressants, of uptake of tritiated

norepinephrine by adrenergic nerves in rabbitaortic strips, kinetic and thermodynamicconsiderations regarding inhibition by, 62

d-Tubocurarine, effect on repetitive firing insoleus nerves caused by germine-3-acetate

and germine-3, 16-diacetate, 223Tye, A., see Seidehamel, R. J., 205H’-Tyramine, regional distribution and metabo-

lism in rat brain, 196H’-Tyrosine, influence of sympathetic nerve stim-

ulation on conversion to H’-catecholamineand on H’-norepinephrine disposition in rab-

bit pulmonary artery, 214

11-14,624 [1-phenyl-3-(2-thiazolyl)-2-thiourea], in

vivo inhibition of dopamine �3-hydroxylase by,80

Vagotomy

effect on cardiovascular effects of Wy-8678, 276effect on heart rate changes induced by cloi.

dine, 256Van Pelt, R., see Baum, T., 276

Vascular smooth muscle, effects of glyceryl tri-nitrate on, 98

Vernikos-Danellis, J., see Muller, P. J., 153

4-C”-Warfarmn sodium, metabolism of, by rat, 307Wenger, H. C., see Scriabine, A., 256Wilk, A. L., Steffek, A. J. and King, C. T. G.:

Norchlorcyclizine analogs : Relationship of

teratogenic activity to in vitro cartilage bind-ing, 118

Williamson, H. E., see Ludens, J. H., 300Wilson, C. B. and Kirkendall, W. M.: The acute

effects of mefruside in man: A new diureticcompound, 288

Wy-8678 (2,6-dichloroben.zylidene aminoguani-dine acetate), antihypertensive agent, generalpharmacologic actions of, 276

Yamada, M.see Frazier, D. T., 45see Narahashi, T., 32

Yamaji, K., see Isaacson, A., 26Yamamoto, A., see Goldstein, M., 196Yanaga, T. and Holland, W. C.: Effect of tetro-

dotoxin on transmembrane potential of atrialmuscle, 20