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CHINA
COMPLIANT
®
LIPID CAPSULES
INFINITECBARCELONA SCIENCE PARK
Helix Building 15-21, Baldiri Reixac08028 BARCELONA (Spain)
B2B information
I
Wrinkle ReductionEpidermal Thickness
96Antiaging%
Available RetinolAfter 3 Months(Stability at 40ºC)
vitAleaseRetinol : maximum stability, bioavailability
and lower irritation potential
Redefine your expectations for retinol-based productsStable high retinol use levels
in a revolutionary, natural delivery system
®
We are active delivery
Lower IrritationPotential
BHT/BHAFREE
3% RETINOLGRADE
B2B Information. Disclaimer : The information in this publication is given in good faith by INFINITEC by way of general guidance and for reference purposes only. The information should not be construed as granting a license to practice any methods or compositions of matter covered by patents. INFINITEC assumes no liability in relation to the information and gives no warranty regarding the suitability of the product and/or ingredients described for a particular use. The use made of the product and/or ingredients described by the recipient and any claims or representations made by the recipient in respect of such product and/or ingredients are the responsibility of the recipient. The recipient is solely responsible for ensuring that products marketed to consumers comply with all relevant laws and regulations.
We are active delivery
CHINA
COMPLIANT
®
LIPID CAPSULES
Retinol is a proven anti-aging powerhouse that can benefit nearly everyone’s skin. Cosmetic customers are looking for stable high-strength retinol solutions with good tolerance (necessary for long-term use) whilst maintaining its effectiveness. vitAlease ® is a cost-effective active ingredient with 7% retinol encapsulated into natural Carnauba wax-based capsules that enables high-strength retinol use levels, improved skin bioavailability and enhanced stability over 3 months.
vitAlease ® capsule SEM image
CAPSULE STRUCTURE
PRODUCT DESCRIPTIONINCI : WATER (AQUA), COPERNICIA CERIFERA CERA, RETINOL, GLYCERIN, PROPANEDIOL,SODIUM COCOAMPHOACETATE, TOCOPHERYL ACETATE, BHT, BHA, XANTHAN GUM.
Additives : 1,2 – HEXANEDIOL, CAPRYLYL GLYCOL
Appearance : Pale yellow to yellow viscous suspension
Solubility : Dispersible in water and in O/W, W/O emulsions
Formulation : It should be incorporated at the endof the formulation at a temperature <40ºC
Recommended dosage : Typical use levels or retinol range from0.1 % to 1.0 % in skin care applications
Retinol level : 7% (171000 -198000 UI/g)
pH : 5.0 – 8.0
Base O/W cream. Level : 0.01% capsules. Marker : RhodamineTechnique : Fluorescence microscopy.
High homogenization, good dispersion and absence of agglomerates after 90 days
CARNAUBA WAX CAPSULENatural , biodegradable lipid carrierLow toxicityGood physical stabilityEntrapment efficiency Stable at high temperatureNo challenges affecting water-soluble delivery systems (active exchange with the medium)200 -400 nm
CAPSULE STABILITY IN O/W OVER TIME
0 Days 90 Days
vitAlease ® STABILITY OVER TIME
Retinol concentration determined after its extraction from vitAlease ® capsules over 30, 60 and 90 days.
100 100 98.5 97.3 97.8 96.5 97.2 95.8
96%
AVAILABLERETINOL
AFTER 90 DAT 40 ºC
7%RETINOL
BIOAVAILABILITY : Free Retinol vs vitAlease ®
Techniques : Pig-skin Franz Cells assay. OECD 428 guidelineFlourescence spectrophotometry. Confocal microscopy images of skin sections
7%
78%
Free Retinol vitAlease ®
t = 0h t = 20h t = 20h
vitAlease ® IRRITATION POTENTIAL
100
50
0
Retin
ol co
nten
t (%
)
0 Days 30 Days 60 Days 90 Days
T = 25 ºC
T = 40 ºC
EFFECTIVE RETINOL
EFFECTIVE RETINOL
BETTER TOLERANCE TO HIGH LEVELS OF RETINOL. SKIN REDNESS ANALYSIS
t = 0h t = 20h
t = 0h t = 20h
2
2
Free Retinol
vitAlease ®DAYS
FOREARM
45 - 55 YRS
PATCH
1%FREE
RETINOL 14%VITALEASE ®
