Upload
hoangcong
View
222
Download
1
Embed Size (px)
Citation preview
We want to save pa,ents with severe cancer and autoimmune diseases Entering clinical phase with our lead an3body CAN04 to our proprietary target
1
Göran Forsberg, CEO, August 2017
Safe Harbour Statement
Thefollowingpresenta2onmayincludepredic2ons,es2matesorotherinforma2onthatmightbeconsideredforward-looking.Thestatementsregardingthesurroundingworldandfuturecircumstancesinthispresenta2onreflectCantargia’scurrentthinkingwithrespecttofutureeventsandfinancialperformance.Prospec2vestatementsonlyexpresstheassessmentsandassump2onsthecompanymakesatthe2meofthepresenta2on.Thesestatementsarewell-considered,buttheaudienceshouldnotethat,aswithallprospec2veassessments,theyareassociatedwithrisksanduncertain2es.
2
Why invest in Cantargia? • Focusonimmuno-oncology-thestrongestgrowingpharmaceu2calsegment
• Takingadvantageofthewellestablishedan2bodytechnologytodesignnoveltargetedpharmaceu2cals
• Leadcandidatean2bodyCAN04withdoublemechanismofac2onenteringclinicalstagewithmul2plevalueinflec2onpoints2017-2019• Ini2aldevelopmentinNSCLCandpancrea2ccancer(cancerformswithpoorprognosis)• Importantclinicalsafetyandefficacydataexpectedinthenext12months
• Secondgenera2onan2bodiesdevelopedforautoimmunedisease• UniqueandstrongIP• Leadinvestorswithhighcompetenceandstrongtrackrecord• Managementandchairmanwithsolidcompetenceinclinicaldevelopment
3
SourceIMSHealth
CAGR6.9% CAGR7.5-10.5%
Lead project CAN04 in the highest growth segment– Oncology an,bodies
World’smostsoldcancerdrugsarean1bodies(2016)Rituxan/MabThera $8.58bnAvas1n $6.75bnHercep1n $6.75bn
Immuno-oncologydrivingmarketgrowth(2016)Opdivo $3.77bn ($0.94bn)Keytruda $1.40bn ($0.57bn)
4
Cantargia at a glance • Specializedinan2bodytherapy/immunology,with
ini2alfocusononcology• GrantedIPontherapeu2ctargetanddrugcandidates• Leadan2bodyCAN04inclinicalstagefromQ32017• Strongmanagementteamwithproventrackrecordin
clinicaldevelopmentandbusinessdevelopment• IPOMarch2015(NasdaqFirstNorth,Stockholm)• Appr3000shareholdersinclspecialistandstronglong
terminvestors• BasedinLund,Sweden
Financialhighlights• Shareprice:6.20SEK(0.77USD),Aug23,2017• Marketcap:199MSEK(24.6MUSD),Aug23,2017• Cash:66.5MSEK(8.2MUSD),June302017
Currentowners(June30,2017)
LUBio 12.6%Sunstone 7.2%AvanzaPension 6.4%DavidOlsson 2.5%BrushamnInvest 2.5%KuduAB 2.4%ThoasFioretos 2.3%MarcusJärås 2.3%MatsInvestAB 2.2%Akademihemman 2.2%Others 57.4%
5
Recent News Flow • CAN04clinicaltrialapplica2on–regulatoryapproval(July2017)
• Collabora2onagreementwithPanoramaResearchInc(Sunnyvale,CA)(June2017)onan2bodydevelopmentinautoimmunedisease
• CAN04patentapplica2on-inten2ontograntbyEPO,no2ceofallowanceUS(April/June2017)
• CAN04strongsafetydatainGLPstudies(May2017)
7
IL1RAP - a novel target on cancer cells
• IL1RAPiden2fiedasacancertarget(severalcancerforms)• IL1RAPregulatesinflamma2on(incl.IL-6andIL-8)• Cantargia’sleadcandidateCAN04isanan2bodyagainstIL1RAP
IL1RAP
Normal cell Cancer cell
8
CAN04 - immuno-oncology mechanism with an,tumor effect
• Antitumor effects in NSCLC PDX models • CAN04 stimulates immune cells to infiltrate tumor
Control CAN04
Cancer cells
Stroma cells
Inflammatory immune cells
Blood vessels
Stromawithinfiltra1ngimmunecells
Iso ty
p e ctr l
C A N 0 40
5
1 0
1 5
2 0
N K 1 .1 + in tu m o r
% N
K1
.1+
tu
mo
r ti
ss
ue p = 0 ,0 0 72
9
0 5 1 0 1 50
5 0 0
1 0 0 0
1 5 0 0
2 0 0 0
2 5 0 0
C A N 0 4 1 0 m g /k g (n = 1 0 )
D a y s
Tu
mo
r v
olu
me
(m
m3
)
V e h ic le
**
C A N 0 4
Is o ty p e c o n tro l
** *
*
CAN04 Clinical Development
• PhaseI/IIatrial-NSCLCandpancrea2ccancer• ApprovaltostartinNorwayand
Denmark• ReviewongoinginBelgiumand
Netherlands• Adap2vedesign(phaseIIapartfinal
designbasedonphaseIandpreclinicaldata)
• PhaseIIainleukemia• PlannedtostartajerphaseIIdose
defined2018
10
CAN04 - Several shots on goal
Focusonthreecancerformswithdifferentbiologicalproper2es,challenges,prognosisandstrategicopportuni2esNextstepdevelopmentcanfocusoncancerform(s)withstrongestefficacysignal
IL1RAP - addi,onal poten,al indica,ons to leverage the value of our asset
• ThreedifferentsystemssignalthroughIL1RAP• Thesesystemscontributetovariousinflammatorydiseases• CanbeblockedbyCantargia’san2bodiesagainstIL1RAP
12
Strategic partnership with Panorama Research Inc PanoramaResearchInc• Privately-ownedbiomedicalR&DcompanyinSiliconValleyCalifornia
• Leaderinan2bodytechnology,managedbyDrJamesW.Larrick
Dealstructure:Panoramashareriskinexchangeforafrac2onoffutureincomes
PanoramaResearch,Inc.A Biotechnology Research& DevelopmentCompany
• CantargiaIL1RAPan2body,affinitymaturedandhumanizedusingPanorama’sproprietarytechnology
• Panoramaalsogeneratescelllinesop2mizedforhighlevelGMPproduc2on
• Cantargiaresponsibleforsubsequentdevelopment13
• Developmentofnewan2bodybindingIL1RAPwithhighaffinity/potentinhibi2onofsignaling• Focusonautoimmune/inflammatorydisease
• Selec2onofclinicalcandidate2019
Management
GöranForsbergCEOsince2014,born1963Göran Forsberghas a PhD in biochemistry, and is an associateprofessor andtheauthorofover40scien2ficpublica2ons.Hehasworkedforpharmaceu2caland biotechnology companies for more than 25 years in various posi2ons,includingatKabiGen,Pharmacia,Ac2veBiotechandtheUniversityofAdelaide,Australia.Forsberg’smostrecentposi2onwasChiefBusinessOfficeratAc2veBiotech AB. He has a large amount of drug development experience, with aspecialfocusononcology.Since2011,ForsbergisaboardmemberofIsogenicaLtd.SharesinCantargia:48,350
Liselo]eLarssonVPOpera9onssince2014,born1963Liselope Larsson has a PhD in biotechnology, and has more than 20yearsofexperienceinvariousmanagementposi2onsinpharmaceu2caland biotechnology companies including BioGaia Fermenta2on,NovozymesBiopharmaandCamurus.Larsson'smainfieldsofexper2seare business development, marke2ng & sales/out licensing, ISOcer2fica2on, good manufacturing prac2ce (GMP) and overall projectmanagement.SharesinCantargia:15,000
LarsThorssonVPClinicalDevelopmentsince2015,born1961LarsThorssongraduatedwithaPh.D.inclinicalpharmacologyin1998.Thorssonhas more than 25 years experience in the pharmaceu2cal industry, includingleading roles in clinical studies andprojectmanagement in a largenumberofdevelopmentphasesatAstraZeneca.Thorsson’smostrecentlyworkedatNovoNordiskA/S,whereheheld the roleof Senior Clinical Pharmacology Scien2st,responsible for prepara2on and implementa2on of clinical pharmacologicalstudies indevelopmentprojects.Thorssonhasbeenresponsibleforevalua2onand documenta2on of new substances and has the experience of regulatoryac2vi2esandinterac2onswithhealthauthori2es.SharesinCantargia:24,998
DavidLibergVPCancerResearchsince2015,born1969David Liberg graduated with a Ph.D. in 2001 and has nearly twentyyearsofresearchexperiencewithinimmunologyandtumourbiology.Liberghasworkedwithinthepharmaceu2cal industryforthelasttenyears,with responsibility for early research projects and ac2vi2es intumourimmunology.Hehasextensiveexperienceofpre-clinicalphasecancer projects. His most recent posi2on was at Ac2ve Biotech AB,where he worked as ProjectManager Drug Development as well asHead of Cell Biology and Biochemistry. Liberg has also carried outresearchatImperialCollegeintheUKandatLundUniversity,Sweden.SharesinCantargia:2,000
14
BengtJöndellCFOsinceMay2017,born1960.Bengt Jondell has a BSc in Business Aministra2on and a MSc in Chemicalengineering. Jondell has extensive experience in various execu2ve financialfunc2ons such as CFO and Chief Execu2ve Officer at BTJ Group AB, SeniorFinancial Advisor for BoneSupport, CFO/Administra2ve manager at Inpac,BusinessControlleratPharmacia&UpjohnConsumerHealthcare,Pharmacia,PharmaciaConsumerPharmaandPharmaciaNicorepe. Jondell´smost recentposi2onwasCFOforEnzyma2caAB.SharesinCantargia10,000
Board of Directors
MagnusPerssonChairmanoftheBoardsince2016,born1960MagnusPerssonisMDandassociateprofessor inphysiologyatKarolinskaIns2tutetinStockholm.Perssonhasalargeamountofexperienceinthefieldsofmedicine,lifesciences and biotech-financing. Persson has previously led development teams inclinical phase II and phase III programmes in the pharmaceu2cal industry and hasfoundedandledprivateaswellaspublicbiotechandmedtechcompanies,eitheraschairman ormember of the board, in Europe and theUSA. Persson has also beeninvolvedinmul2pleIPOs.SharesinCantargia:28,110and85,000op2ons
LarsH.BruzeliusBoardmembersince2013,born1943Lars H. Bruzelius is an associate professor in Business Administra2on andmanagement consultant with many years of experience working with banks andcompanies in theenergy,medtechand telecommunica2on industries.Bruzelius isaseniorpartner inand jointownerofBSI&Partners,andhasbeenaboardmemberand chairman of LU Bioscience AB since 2012. For three years, Bruzelius was theDeputyChiefExecu2veandAdministra2veDirectorofGambroAB.Bruzeliushasbeenaboardmemberoftwolistedcompaniesaswellasaninvestorandboardmemberofanumberofstart-upcompanies.SharesinCantargia792,577
KarinLeanderssonBoardmembersince2016,born1972Karin Leandersson is associate professor and lecturer in tumourimmunology at themedical faculty of LundUniversity. She has gained awide range of cancer research experience in the fields of tumourimmunologyand tumour inflamma2on in solid tumours,mainly inbreastcancer.Leanderssonhasalsoauthoredaround30scien2ficpublica2onsininterna2onaljournals.SharesinCantargia:0
ThoasFioretosBoardmembersince2010,born1962ThoasFioretos isaprofessorandphysicianat theDepartmentofClinicalGene2cs at Lund University. The focus of his research is molecular andfunc2onalstudiesofgene2cchangesinleukaemiaandhowsuchchangescan be used for diagnos2c and therapeu2c purposes. Fioretos hasauthored many scien2fic publica2ons, and is one of the founders ofCantargiaABandbio-ITcompanyQlucoreAB.SharesinCantargia:732,600
ClausAsbjørnAnderssonBoardmembersince2013,born1968ClausAsbjørnAnderssonisapartnerofSunstoneLifeScienceVentures,aholdingcompanymanagingbillion-dollarventurefunds.HehasaMaster’sdegreeinCivilChemicalEngineeringfromTechnicalUniversityofDenmarkand a PhD in Mathema2cal Sta2s2cs from Copenhagen University andHumboldt University of Berlin. Andersson has himself founded fourEuropeanstart-upcompanies,includingtwoinDenmark.HehasbeenwithSunstone Life Sciences since its establishment in 2007, and is an ac2vemember of the Interna2onal Venture Club and advisor to the EuropeanCommission.SharesinCantargia:0
NiclasLundqvistBoardmembersince2016,born1965NiclasLundqvistisaMasterofLawatlawfirmAdvokatbolagetWiklundGustavii.Since1996, he has specialized in legal counselling with companies listed on the SwedishstockmarketorMTF.Lundqvisthasopera2onalexperiencefromboardsofcompanieslisted on the Swedish stock market and companies under the supervision ofFinansinspek2onen.Hispreviousexperienceincludesothertypesoflegalwork,projectmanagement and business development in Corporate Finance at SedermeraFondkommission from 2003 to 2013. Lundqvist is one of the founders of venturecapitalfund'SwedishGrowthFund'.SharesinCantargia:0
15
Signficant value inflec,on points ahead
2017• Ini2a2onofphaseI/IIatrial• Preclinicaldataoncombina2ontherapyH12018• Presenta2onofPhaseIclinicaldata• Ini2a2onofPhaseIIapor2onoftheclinicaltrial• Prepara2onsfortheclinicalphaseIIaofleukemia
16
Why invest in Cantargia? • Focusonimmuno-oncology-thestrongestgrowingpharmaceu9calsegment
• Takingadvantageofthewellestablishedan9bodytechnologytodesignnoveltargetedpharmaceu9cals
• Leadcandidatean9bodyCAN04withdoublemechanismofac9onenteringclinicalstagewithmul9plevalueinflec9onpoints2017-2019• Ini9aldevelopmentinNSCLCandpancrea9ccancer(cancerformswithpoorprognosis)• Importantclinicalsafetyandefficacydataexpectedinthenext12months
• Secondgenera9onan9bodiesdevelopedforautoimmunedisease• UniqueandstrongIP• Leadinvestorswithhighcompetenceandstrongtrackrecord• Managementandchairmanwithsolidcompetenceinclinicaldevelopment
17