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Baylor St. Luke’s Medical Center, Houston, TX
Baylor St. Luke’s Medical Center
WHEN IS ESOPHAGECTOMY THE BEST FOR
BENIGN ESOPHAGEAL DISEASES?
David J. Sugarbaker, M.D.Director, The Lung Institute
Chief, Division of Thoracic SurgeryThe Olga Keith Weiss Chair of Surgery
Baylor College of Medicine
Baylor St. Luke’s Medical Center, Houston, TX
Baylor St. Luke’s Medical Center
Indications• Primary motility disorder (Dysfunctional esophagus) End Stage Achalasia Refractory esophageal motility disorder
• GERD Failed anti-reflux surgery
• Refractory stricture
Baylor St. Luke’s Medical Center, Houston, TX
Baylor St. Luke’s Medical Center
Indications• Watson et al, 1998• 104 patients from 1975-1996 requiring
esophagectomy for benign disease• 98% felt cured or improved symptoms• 2% mortality rate
Watson TJ, DeMeester TR, Kauer WK, Peters JH, Hagen JA. Esophageal replacement for end-stage benign esophageal disease. J Thorac Cardiovasc Surg. 1998;115(6):1241-7; discussion 7-9.
Baylor St. Luke’s Medical Center, Houston, TX
Baylor St. Luke’s Medical Center
Indications
Watson TJ, DeMeester TR, Kauer WK, Peters JH, Hagen JA. Esophageal replacement for end-stage benign esophageal disease. J Thorac Cardiovasc Surg. 1998;115(6):1241-7; discussion 7-9.
Baylor St. Luke’s Medical Center
Indications• Madenci et al 2013• 661 underwent esophagectomy
for benign disease• 111 had prior intervention
Madenci AL, Reames BN, Chang AC, Lin J, Orringer MB, Reddy RM. Factors associated with rapid progression to esophagectomy for benign disease. J Am Coll Surg. 2013;217(5):889-95. Baylor St. Luke’s Medical Center, Houston, TX
Baylor St. Luke’s Medical Center, Houston, TX
Baylor St. Luke’s Medical Center
Madenci AL, Reames BN, Chang AC, Lin J, Orringer MB, Reddy RM. Factors associated with rapid progression to esophagectomy for benign disease. J Am Coll Surg. 2013;217(5):889-95.
Indications for esophagectomy
•May consider esophagectomyafter 2nd/3rd intervention
Baylor St. Luke’s Medical Center
Achalasia• Refractory dysphagia from
atonic esophagus
• Megaesophagus, sigmoid esophagus
Watson TJ. Esophagectomy for end-stage achalasia. World J Surg. 2015;39(7):1634-41.
D.J. Sugarbaker; R. Bueno, Y.L. Colson, M.T. Jaklitsch, M.J. Krasna, S.J. Mentzer, M.Williams, A. Adams: Adult Chest Surgery, 2nd Edition: www.accesssurgery.com
Baylor St. Luke’s Medical Center, Houston, TX
Baylor St. Luke’s Medical Center
https://radiologykey.com/esophageal-achalasia-2
Watson TJ. Esophagectomy for end-stage achalasia. World J Surg. 2015;39(7):1634-41.
Baylor St. Luke’s Medical Center, Houston, TX
Baylor St. Luke’s Medical Center
Achalasia• Esophagectomy may be required in up to 5% of
patients with achalasia
• Molena et al showed lower postoperative mortality (2.9 vs. 7.8 %, p = 0.08) in patients with achalasia undergoing esophagectomy when compared for cancer
Duranceau A, Liberman M, Martin J et al (2012) End-stage achalasia. Dis Esophagus 25:319–330Molena D, Mungo B, Stem M, Feinberg RL, Lidor AO (2014) Outcomes of esophagectomy for esophageal achalasia in the United States. J Gastrointest Surg 18:310–317
Baylor St. Luke’s Medical Center, Houston, TX
Baylor St. Luke’s Medical Center
Achalasia Outcomes after EsophagectomyAuthor N Year Conduit Mortality Follow-up
(years)Outcomes
Peters et al. 19 1995 Colon 0 6 93 % cured/improved/satisfied
Miller et al. 37 1995 Stomach = 26colon = 6small bowel = 5
5.4 % 6.3 91 % excellent/good
Banbury et al. 32 1999 Stomach 0 3.6 87 % “felt better”
Devaney et al. 93 2001 Stomach = 91colon = 2
2 % 3.2 93 % “felt better”
Hsu et al. 9 2003 Colon (short) 0 6 75 % good
Watson TJ. Esophagectomy for end-stage achalasia. World J Surg. 2015;39(7):1634-41.
Baylor St. Luke’s Medical Center, Houston, TX
Baylor St. Luke’s Medical Center
Other Motility Disorders• Diffuse esophageal spasm• Scleroderma
Waters PF, Pearson FG, Todd TR, et al. Esophagectomy for complex benign esophageal disease. J Thorac Cardiovasc Surg. 1988;95(3):378–381.Orringer MB, Orringer JS. Esophagectomy: definitive treatment for esophageal neuromotor dysfunction. Ann Thorac Surg. 1982;34(3):237–248.
Baylor St. Luke’s Medical Center, Houston, TX
Baylor St. Luke’s Medical Center
GERD
D.J. Sugarbaker; R. Bueno, Y.L. Colson, M.T. Jaklitsch, M.J. Krasna, S.J. Mentzer, M.Williams, A. Adams: Adult Chest Surgery, 2nd Edition: www.accesssurgery.com
Baylor St. Luke’s Medical Center, Houston, TX
Baylor St. Luke’s Medical Center
GERD• Up to 6% of all anti-reflux procedures
will require re-operative intervention• Options after failed anti-reflux surgery
include: Redo fundoplication Roux-en-Y diversion Esophagectomy
Pennathur A, Awais O, Luketich JD. Minimally invasive redo antireflux surgery: lessons learned. Ann Thorac Surg. 2010;89(6):S2174-9.
Baylor St. Luke’s Medical Center, Houston, TX
Baylor St. Luke’s Medical Center
GERD• Awais et al, 2011• Retrospective review of 275
patients underwent redo antireflux surgery
Awais O, Luketich JD, Schuchert MJ, Morse CR, Wilson J, Gooding WE, et al. Reoperative antireflux surgery for failed fundoplication: an analysis of outcomes in 275 patients. Ann Thorac Surg. 2011;92(3):1083-9; discussion 9-90.
Baylor St. Luke’s Medical Center, Houston, TX
Baylor St. Luke’s Medical Center
GERD• 31 patients (11.3%) had failure of redo 4 patients required esophagectomy
Trend for multiple redo operations to be associated with failure Conversion to esophagectomy individualized, not specific to # of
redo surgeries
Awais O, Luketich JD, Schuchert MJ, Morse CR, Wilson J, Gooding WE, et al. Reoperative antireflux surgery for failed fundoplication: an analysis of outcomes in 275 patients. Ann Thorac Surg. 2011;92(3):1083-9; discussion 9-90.
Baylor St. Luke’s Medical Center, Houston, TX
Baylor St. Luke’s Medical Center
GERD Review experience of patients
undergoing esophagectomy after fundoplication, 1988-2008• 80 patients underwent esophagectomy after
at least 1 prior anti-reflux surgery• Compared to matched controls undergoing
esophagectomy for esophageal cancer
Shen KR, Harrison-Phipps KM, Cassivi SD, Wigle D, Nichols FC, 3rd, Allen MS, et al. Esophagectomy after anti-reflux surgery. J Thorac Cardiovasc Surg. 2010;139(4):969-75.
Baylor St. Luke’s Medical Center, Houston, TX
Baylor St. Luke’s Medical Center
GERD• Mortality 3.7%
• Patients with previous anti-reflux surgery when undergoing esophagectomy had higher rates of anastomotic leak when compared to control group
Shen KR, Harrison-Phipps KM, Cassivi SD, Wigle D, Nichols FC, 3rd, Allen MS, et al. Esophagectomy after anti-reflux surgery. J Thorac Cardiovasc Surg. 2010;139(4):969-75.
Baylor St. Luke’s Medical Center, Houston, TX
Baylor St. Luke’s Medical Center
GERD• Chang et al, 2010• Retrospective review, 258 patients Evaluate the impact of prior
gastroesophageal operations on outcomes after esophagectomy for recurrent GERD or hiatal hernia.
• 2% mortality
Chang AC, Lee JS, Sawicki KT, Pickens A, Orringer MB. Outcomes after esophagectomy in patients with prior antireflux or hiatal hernia surgery. Ann Thorac Surg. 2010;89(4):1015-21; discussion 22-3.
Baylor St. Luke’s Medical Center, Houston, TX
Baylor St. Luke’s Medical Center
GERD• In setting of previous GERD/hiatal hernia
surgery:• Transhiatal resection accomplished in
fewer patients undergoing reoperation• Gastric conduit was used as the
esophageal replacement in fewer patients• Fewer patients reported good to excellent
swallowing functionChang AC, Lee JS, Sawicki KT, Pickens A, Orringer MB. Outcomes after esophagectomy in patients with prior antireflux or hiatal hernia surgery. Ann Thorac Surg. 2010;89(4):1015-21; discussion 22-3.
Baylor St. Luke’s Medical Center, Houston, TX
Baylor St. Luke’s Medical Center
Stricture• Majority of experience for esophagectomy for
caustic injury is in pediatric population• Typically performed after serial dilations for
stricture have failed• No consensus on type of esophageal
replacement in pediatric population
Hamza AF, Abdelhay S, Sherif H, Hasan T, Soliman H, Kabesh A, et al. Caustic esophageal strictures in children: 30 years' experience. J Pediatr Surg. 2003;38(6):828-33.
Baylor St. Luke’s Medical Center, Houston, TX
Baylor St. Luke’s Medical Center
Choice of conduit• Conduit: stomach, colon, jejunum• Location: posterior mediastinum,
retrosternal• Operative technique: transhiatal,
transthoracic, minimally invasive, vagal-sparing
• No randomized controlled trials, Level 1 data supporting one method over other
Colon Interposition Brian E. Louie, Steven R. DeMeesterPearson's Thoracic and Esophageal Surgery, chapter 59, 630-642
Blackmon SH, Correa AM, Skoracki R, Chevray PM, Kim MP, Mehran RJ, et al. Supercharged pedicledjejunal interposition for esophageal replacement: a 10-year experience. Ann Thorac Surg. 2012;94(4):1104-11; discussion 11-3.
Baylor St. Luke’s Medical Center, Houston, TX
Baylor St. Luke’s Medical Center
Conclusion• Esophagectomy can be an effective treatment in patients with end
stage esophageal disease• Reconstruction can be done with low mortality and acceptable
morbidity• Operative approach and choice of conduit is up to surgeon experience
and needs to be individualized • Assessment and surgery should be done by experienced surgeons at
high volume centers
Baylor St. Luke’s Medical Center, Houston, TX
Baylor St. Luke’s Medical Center
Thank you