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WHI Investigators Meeting
May 3-4, 2012
Status of follow-up: Extension II
Response to mailings Overall Response
F33 Overall MRC SRC Overall MRC SRC
Year 1 91.7% 87.9% 92.9% 97.2% 96.5% 97.4%
Year 2 89.1% 86.0% 90.2%
WHI Productivity-Ancillary Studies
Funding success 2009 – 38 submitted, 17 funded, 45% 2010 – 40 submitted, 16 funded, 40% 2011 – 41 submitted, 7 funded 17% with 11
still pending
Robert Brunner, Chair, Ancillary Studies Committee
ASC members Co-chair, Marian Neuhouser Garnet Anderson Tim Assimes Bette Caan Charles Eaton Gerardo Heiss Li Jiao Karen Johnson Lew Kuller Jennifer Lin Simin Liu Gloria Sarto Eric Whitsel
Publications and Presentations
Cynthia Thomson Barbara Howard
P&P Members Peggye Dilworth-Anderson Hoda Anton-Culver Rowan Chlebowski Laura Coker Jennifer Hays-Grudo Keri Monda Kari North Mary Jo O’Sullivan Ross Prentice Stephen Rapp Sylvia Smoller Lesley Tinker Robert Wallace Jean Wactawski-Wende
Linda Van Horn Shirley Beresford Giselle Corbie-Smith Mark Espeland Nora Franceschini Margery Gass Jane Kotchen Andrea LaCroix Simin Liu Yvonne Michael Jacques Rossouw Michael Simon Sally Shumaker Marcia Stefanick
Top 10 lead authors:Rowan Chlebowski, Ross Prentice, Geoffrey Kabat, Judith Hsia, JoAnn
Manson, Jacques Rossouw, Zhao Chen, Mark Espeland, Barbara Howard, Karen Margolis
Outcomes Advisory Committee Marian Limacher,
Chair Karen Margolis, Co-chair Matt Allison Charles Eaton Susan Heckbert Charles Kooperberg Joyce Noonan (OC Rep.) Marcia Ko Andrea LaCroix Kamakshi Lakshminarayan Shari Ludlam Bernedine Lund Jennifer Robinson
Outcomes status Extension I cases adjudication complete except
Retrospective DVT cases (N=300, target completion, 8/2012)
HF All 11,000 cancer Extension I cases have been
coded Since 10/01/10
7990 outcomes identified 5992 cases were sent forward adjudication
Electronic adjudication has been implemented for CVD/fracture/death outcomes
Abstraction of HF cases is moving forward at UNC
Cancers identified in WHI
Cancer Site NBreast 7787Lung 2246Colorectal 2211Endometrial 1321Lymphoma 1133GU 804Melanoma (skin) 769Ovary 685Other GI 606Leukemia 575Pancreas 559Thyroid 345Multiple Myeloma 342Other Gyn 274Brain 201Head and Neck 114Other/unknown/Ill-defined 791
Total2076
3
Adjudicators Carl Chelius Eric Whitsel George Hess Judith Hsia Karen Margolis Kathryn Rexrode Kim Miller Linda Loes Marcia Ko Marian Limacher Maurizio Trevisan Stephanie Connelly Steve Sidney Susan Heckbert
Beth Lewis Charles Eaton Matt Allison Stroke Amie Hsia Brian Silver Enrique Leira Jana Wold Jose Merino Kamakshi
Lakshminarayan Lenore Ocava John Lynch
New Initiatives Long-Life Study (CCC)/OPACH (Andrea LaCroix, PI)
Consent mailings started in February—1602 consented Visits started in March—381 completed, 532 scheduled Projected completion of visits by second quarter 2013
Clinical Trial working group (Mark Espeland, chair) Reviewed 19 concept proposals Selected 2 to support for studywide effort
Manson and Sesso Factorial design of 2 dietary supplements, alpha linoleic acid and
cacao 10,000 women at elevated CVD risk
Stefanick A pragmatic trial of physical activity
Resources Sharepoint
Access at www.whiscience.org
Data enclave Physical enclave in place Seeking CMS/IRB approval for virtual enclave
Medicare data CCC has files covering 1991-2010 Application for Part D has been developed Annual updates expected
Regional Center Analysts
Scientific Interest Groups & Chairs Aging: Stephen Rapp Bone, Fracture and Body Composition: Carolyn
Crandall, Jean Wactawski-Wende Cancer: Bette Caan, Ross Prentice, Rowan
Chlebowski Cardiovascular Disease: Marcia Stefanick Genetics, Proteomics & Biomarkers: Rebecca
Jackson Health Services: Karen Margolis Minorities and Health Disparities: Laura Coker
Scientific Interest Groups & Chairs Nutrition/Energy Balance: Marian Neuhouser Diabetes and Obesity: Lesley Tinker, Jean
Wactawski-Wende Physical and Built Environment: Eric Whitsel Physical Activity: Marcia Stefanick Psychosocial & Behavioral Health: Sally
Shumaker
Rebecca Jackson, SRWG chair