Curriculum VitaeXiankai Sun, PhD

Date Prepared: September 12, 2011Name: Xiankai Sun, PhD

Office Address: NE3.120A, Clements Imaging Building

Work Phone: 214-645-5978

Work Fax: 214-645-2885

Work E-Mail: Xiankai.Sun@UTSouthwestern.edu

Place of Birth: Hubei, China

Education

Year Degree Field of Study(Thesis advisor for PhDs)

Institution

1986 BS Chemistry Department of ChemistryWuhan UniversityWuhan, China

1989 MS Chemistry Institute of Applied ChemistryChinese Academy of SciencesChangchun, China

2000 PhD Inorganic Chemistry(Mentor: Edward H. Wong)

University of New Hampshire

Postdoctoral Training

Year(s) Titles Specialty/Discipline(Lab PI for postdoctoral research)

Institution

2000 - 2003 Postdoctoral Research Associate

Radiopharmaceutical Chemistry(Mentors: Michael J. Welch and Carolyn J. Anderson)

Mallinckrodt Institute of RadiologyWashington University School of Medicine in St. Louis

Current Licensure and Certification N/A

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Honors and Awards

Year Name of Honor/Award

Awarding Organization

1998 Gloria and Robert Lyle Award

University of New Hampshire

2005 Pilot Research Award

Society of Nuclear Medicine

2010 Translational Image of the Year

Siemens: the 7th Annual Preclinical Image of the Year Contest

Faculty Academic Appointments

Year(s) Academic Title

Department Academic Institution

2003 - 2004 Research Instructor

Radiology Washington University School of Medicine

2004 - 2012 Assistant Professor

Radiology UT Southwestern

2009 - 2012 Assistant Professor

Advanced Imaging Research Center

UT Southwestern

2012 - present Associate Professor

Radiology and Advanced Imaging Research Center

UT Southwestern

2012 - present Dr. Jack Krohmer Professorship in Radiation Physics

UT Southwestern

Appointments at Hospitals/Affiliated Institutions N/A

Other Professional Positions N/A

Major Administrative/Leadership Positions

Year(s) Position Title Institution2011 - present Director of Cyclotron and Radiochemistry

Program UT Southwestern

Committee Service

Year(s) Name of Committee Institution/OrganizationUTSW2005 - 2007 Graduate Student Committee (Gang Ren) Radiology2005 - 2006 Graduate Student Committee (Jacob Schwartz) Pharmacology2006 - 2007 Graduate Student Committee (Allison Carroll) Surgery

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Hospital N/A

State/Regional2007 - present Graduate Student Committee (James

Nyagilo)University of Texas – Arlington Biomedical Engineering

2011 - present Graduate Student Committee (Bilal Khan)

University of Texas – Arlington Biomedical Engineering

2011 - present Graduate Student Committee (Yi Zhang) University of Texas – Arlington Biomedical Engineering

2012 - present Graduate Student Committee (Yi-Ting Tsai)

University of Texas – Arlington Biomedical Engineering

National/International N/A

Professional Societies

Year(s) Society Name1997 - present American Chemical Society2000 - present American Association of the Advancement of Science2001 - present Society of Nuclear Medicine2008 - present International Society of Radiopharmaceutical Sciences

Grant Review Activities

Year(s) Name of Review Committee Organization2008 NIDDK R24 NIH2008 External Grant Review Panel University of Oklahoma

Cancer Institute2009 Stage 1 Reviewer of Challenge Grants in

Health and Science ResearchNIH

2009 Invited International Reviewer Panel China’s National Science Foundation

2010 SBMI-T Study Section NIH

Editorial Activities

Year(s) Journal NameEditor/Associate Editor2011 - present Reviews in Nanoscience and Nanotechnology

Editorial Board2011 - present Frontiers in Cancer Imaging and Diagnosis2011 - present American Journal of Nuclear Medicine and Molecular Imaging

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Ad Hoc Reviewer2004 - present Society of Nuclear Medicine Annual Meeting Abstract Reviewer2007 - present Society of Radiopharmaceutical Science’s Symposium Abstract Reviewer2010 - present World Congress of Molecular Imaging Annual Meeting Abstract ReviewerJournal Ad Hoc Reviewer

Year(s) Journal Name2004 - present ACS Nano

2004 - present Advanced Drug Delivery Reviews2004 - present Amino Acids

2004 - present Biochemistry

2004 - present Bioconjugate Chemistry

2004 - present Bioorganic Medicinal Chemistry

2004 - present Bioorganic Medicinal Chemistry Letters

2004 - present Cancer Research

2004 - present Cancer Chemotherapy & Pharmacology

2004 - present Chemical Reviews

2004 - present Clinical Cancer Research

2004 - present Critical Reviews in Oncology/Hematology

2004 - present Current Analytical Chemistry

2004 - present Current Medicinal Chemistry

2004 - present Current Pharmaceutical Design

2004 - present Current Radiopharmaceuticals

2004 - present Dalton Transactions

2004 - present European Journal of Medicinal Chemistry

2004 - present European Journal of Nuclear Medicine and Molecular Imaging

2004 - present Expert Opinion on Drug Delivery

2004 - present Frontiers in Cancer Imaging and Diagnosis

2004 - present Inorganic Chemistry

2004 - present Journal of Labelled Compounds and Radiopharmaceuticals

2004 - present Journal of Medicinal Chemistry

2004 - present Journal of Nuclear Medicine

2004 - present Molecular Imaging

2004 - present Molecular Imaging and Biology

2004 - present Molecular Pharmaceutics

2004 - present Nano Letters

2004 - present Nuclear Medicine and Biology

2004 - present Organic & Biomolecular Chemistry

2004 - present Reviews in Nanoscience and Nanotechnology

2004 - present Science Signaling2011 - present Science2004 - present Theranostics2004 - present Tetrahedron

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Invited Lectures [Since last promotion/appointment]

Year(s) Title LocationInternational2007 What is PET in the Mind of a

Chemist?Peking UniversityJuly 24, 2007

2007 Recent Advances in Molecular Imaging of Pancreatic Beta CellsThe 8th Chinese Symposium on Nuclear Cardiology

Xiamen, ChinaJuly 06 – 08, 2007

2010 Novel GLP-1 Peptides for Pancreatic Beta Cell ImagingThe 11th International Congress on Amino Acids, Peptides and Proteins

Vienna, Austria August 2 – 7, 2010

2011 Visualization of Nanomedicine & Beyond

Jawaharlal Nehru Centre for Advanced Scientific ResearchBangalore, India February 15, 2011

2011 Multivalent Bifunctional Chelator Scaffold Design for PET/SPECT Imaging of Cancer

Bangalore, IndiaFebruary 16 – 18, 2011

National2007 Nanoconjugates in Drug Delivery The Cleveland Clinic,

OhioDecember 10, 2007

2008 Towards PET Imaging of Pancreatic Beta Cells

Department of Nuclear Medicine The State University of New York at Buffalo, New YorkJanuary 28, 2008

2008 Molecular Imaging and Chemistry Alnylam Pharmaceuticals Cambridge, MassachusettsJuly 15, 2008

2008 Nanoconjugates for Drug Delivery and Molecular Imaging

University of Oklahoma Cancer Institute August 19, 2008

2008 Development of Dual-modality Imaging Probes for Prostate Cancer The 27th Annual Meeting of the Society of Nuclear Medicine’s Eastern Great Lakes Chapter.CME Course/Credit

Niagara Falls, NY October 17, 2008

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Invited Lectures [Since last promotion/appointment] (cont’d)

2008 Dual-modality Imaging Techniques of Cancer DetectionThe 27th Annual Meeting of the Society of Nuclear Medicine’s Eastern Great Lakes Chapter.CME Course/Credit

Niagara Falls, NYOctober 18, 2008

2010 Imaging the Pancreatic Beta Cells College of Pharmacy Purdue University Lafayette, IndianaMarch 31, 2010

2010 Nanoconjugates for Drug Delivery and Molecular Imaging

Alnylam Bioimaging KOLCambridge, MassachusettsMay 11, 2010

Regional/Local2006 Chemistry and PET Imaging University of Texas –

ArlingtonDepartment of Biomedical EngineeringDecember 1, 2006

2007 Host of a one-day hands-on workshop Nuclear Imaging: Instrumentation and Chemistry

The 7th Annual ICMIC Symposium at UT Southwestern Dallas, TexasOctober 16, 2007

2008 Nanoconjugates for Dual Modality Imaging of Cancer

University of Texas – Arlington Department of Biomedical EngineeringOctober 22, 2008

2008 Host of a one-day hands-on workshop: Radiochemistry and PET Imaging

The 8th Annual ICMIC Symposium at UT Southwestern Dallas, TexasNovember 14, 2008

2008 PET Chemistry: Imaging Probe Design and Synthesis 2008 M.R. & Evelyn Hudson Foundation Radiology Residency Research Forum

UT Southwestern – RadiologyNovember 14, 2008

2009 Preclinical PET Imaging and Radiochemistry at UT Southwestern: Current Status and

UT Southwestern – The Touchstone Diabetes Center

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Perspectives April 14, 2009 Invited Lectures [Since last promotion/appointment] (cont’d)

2009 Molecular Imaging: Diagnosis and Prognosis of Prostate Cancer Prostate Cancer Symposium N. Texas Prostate Cancer Alliance

University of North Texas at DentonSeptember 12, 2009

2009 Chemistry Seminar Series: Design and Synthesis of Targeted PET Imaging Probes

University of Texas – DallasOctober 09, 2009

2009 Biomedical Engineering Video- Conference Seminar Series: Positron Emission Tomography (PET): Imaging Probe Design and Applications

University of Texas – ArlingtonNovember 6, 2009

2010 Radiochemistry and PET for Cancer Imaging

Cancer Center Imaging Retreat; UT SouthwesternApril 16, 2010

2010 PET for Understanding Cancer Biology Symposium and Training XVIII Intermediary Metabolism in CancerCME Course/Credit

UT SouthwesternMay 20, 2010

2010 Nanoconjugates for Drug Delivery and Molecular Imaging

University of Texas – ArlingtonDepartment of PhysicsAugust 5, 2010

2010 Biomedical Engineering Video- Conference Seminar Series: Noninvasive Assessment of Pancreatic Beta Cells

University of Texas – ArlingtonNovember 19, 2010

2011 PET Research at UT Southwestern UT Southwestern – Radiation OncologyApril 26, 2011

2011 Prostate Cancer Working Group Seminar Series: Nuclear Imaging Techniques for Diagnosis & Prognosis of Prostate Cancer

UT Southwestern – UrologyJune 22, 2011

2011 Theranostic Agents Towards Cancer Imaging and Therapy

Department of PhysicsUniversity of Texas – ArlingtonSeptember 14, 2011

2011 Graduate Materials Seminar Series: Towards Nanomedicine – How would imaging techniques help?

University of Texas – Arlington Department of Material Sciences & EngineeringOctober 7, 2011

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Technological and Other Scientific InnovationsInnovation

1. Becker, Matthew L.; Fang, Huafeng; Li, Xiaoxu; Pan, Dipanjan; Rossin, Raffaella; Sun, Xiankai; Taylor, John-Stephen; Turner, Jeffrey L.; Welch, Michael John; Wooley, Karen L.: Cell-permeable nanoconjugates of shell-crosslinked knedel (sck) and peptide nucleic acids ("PNAs") with mRNA-targeting sequences for early diagnosis and therapy of cancer. PCT Int. Appl. (2006), Application: WO 2005-US37112 20051014. Priority: US 2004-619242, 20041015.

2. Jer-Tsong Hsieh, Jian Zhou, and Xiankai Sun: Probe sequences and application of imaging and therapeutic targeting of human prostate and bladder tissues. U.S. Pat. Appl. Publ. (2009), 64pp. CODEN: USXXCO US 2009123381 A1 20090514

3. Jung-Mo Ahn and Xiankai Sun: Cyclic GLP-1 analogues for non-invasive imaging of pancreatic beta-cells to diagnose diabetes mellitus. PCT Int. Appl. (2010), WO 2010118034 A2 20101014.

Service to the Community

Year(s) Role Organization or institution

2005 - 2008

Primarily responsible for the design and construction of the Preclinical Nuclear Imaging Laboratory on the 3rd floor of the Clements Imaging Building

UT Southwestern

Proactively promoted the role of PET and SPECT in biomedical research and molecular imaging; and solely endeavored in the development of radiochemistry and imaging capability from scratch at UT Southwestern with capital investments from the University, Cancer Center, Radiology, and Advanced Imaging Research Center

2008 - present

Primarily responsible for the maintenance and operations of the UT Southwestern Preclinical Nuclear Imaging Laboratory

UT Southwestern

Have been actively providing radiochemistry services, nuclear imaging consultation, PET data analysis and interpretation, and radiochemistry/PET related writings to more than 30 investigators of UT-Metroplex Institutes (UT Southwestern, UT Dallas, and UT Arlington) for research project implementation and grant applications.

Service to the Community (cont’d)

2009 - present

Primarily responsible for the setup of the UT Southwestern Cyclotron and Radiochemistry Facility

UT Southwestern

Led an institutional effort for an NIH High-End Instrumentation application for a biomedical cyclotron in 2009, which prompted enthusiastic supports from six major user groups (Neuroscience, Oncology, Cardiology, Metabolism, Biochemistry, Autoimmunity) representing 25 major users with 47 NIH major grants and18 minor users with 24 federally funded projects across campus. The application was scored 24 but not funded.

Led an institutional effort in 2010 to successfully win an instrumentation award from the Cancer Prevention and Research Institute of Texas to setup a Cyclotron and Radiochemistry Facility at UT Southwestern: $2.7M for instrument purchases and $1.5M to develop a comprehensive program of radiochemistry over 5 years. In addition, an institutional commitment has been obtained for the facility setup and operation. The goal is to have a self-sufficient cyclotron facility within 1 (construction) + 5 (operation) years.

Primarily responsible for the cyclotron facility setup: personnel recruitment, cyclotron (and accessories) selection,

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cyclotron site state RAM license application, site planning and construction including a cGMP radiopharmacy (21 CFR Part 212), FDA NDA/ANDA/IND filings, PET tracer deliveries, and coordination of clinical/preclinical PET imaging studies (humans, swine, rodents). Directly report to Dr. Neil Rofsky, Chairman of Radiology, and Dr. Dean Sherry, Director of Advanced Imaging Research Center, regarding the works-in-progress of the cyclotron facility.

Bibliography

Peer-Reviewed Publications Original Research Articles

1. Sun X, Johnson DW, Caulder DL, Powers RE, Raymond KN, Wong EH: Exploiting Incommensurate Symmetry Numbers: Rational Design and Assembly of M2M'3L6 Supramolecular Clusters with C3h

Symmetry. Angew. Chem. Int., Ed. 1999; 38(9):1303-1307; Angew. Chem., 1999; 111:1386-1390. 2. Sun X, Johnson DW, Raymond KN, Wong EH: A Silver-Linked Supramolecular Cluster Encapsulating a

Cesium Cation. Inorg. Chem., 2001, 40(17), 4504-4506. 3. Sun X, Johnson DW, Caulder DL, Raymond KN, Wong EH: Rational Design and Assembly of M2M'3L6

Supramolecular Clusters with C3h Symmetry by Exploiting Incommensurate Symmetry Numbers. J. Am. Chem. Soc., 2001; 123:2752-2763.

4. Sun X, Wuest M, Weisman GR, Wong EH, Reed DP, Motekaitis R, Martell AE, Welch MJ, Anderson CJ: Radiolabeling and In Vivo Behavior of Copper-64-Labeled Cross-Bridged Cyclam Ligands, J. Med. Chem., 2002; 45(2):469-477.

5. Sun X, Wuest M, Kovacs Z, C, Motekaitis R, Wang Z, Martell AE, Welch MJ, Anderson CJ: In Vivo Behavior of Copper-64-Labeled Tetraazamacrocyclic Methanephosphonate Ligands. J. Biol. Inorg. Chem., 2003; 8(1-2):217-225.

6. Boswell CA, Sun X, Weisman GR, Wong EH, Anderson CJ: In vivo Stability of Copper-64-labeled-Azamacrocyclic Complexes: Comparison of TETA and DOTA with Cross-bridged Chelators. J. Med. Chem., 2004; 47(6):1465-1474.

7. Sun X, Kim J, Martell AE, Welch MJ, Anderson CJ: In vivo evaluation of copper-64-labeled monooxo-tetraazamacrocyclic Ligands. Nucl. Med. Biol., 2004; 31:1051-1059.

8. Sprague JE, Peng Y, Sun X, Weisman GR, Wong EH, Achilefu S, Anderson CJ: “Preparation and Biological Evaluation of Copper-64-labeled Tyr3-octreotate using a Cross-Bridged Macrocyclic Chelator” Clin. Cancer Res., 2004, 10, 8674-8682.

9. Sun X, Fang H, Li X, Rossin R, Welch MJ, and Taylor J-S: MicroPET Imaging of MCF-7 Tumors in Mice via unr mRNA-targeted Peptide Nucleic Acids. Bioconjugate Chem., 2005, 16, 294-305.

10. Sun X, Rossin R, Turner JL, Becker ML, Joralemon MJ, Welch MJ, and Wooley KL: An Assessment of the Effects of Shell Cross-Linked Nanoparticle Size, Core Composition, and Surface PEGylation on in Vivo Biodistribution. Biomacromolecules 2005, 6(5), 2541-2554.

11. Rossin R., Pan D., Qi K., Turner JL, Sun X., Wooley KL, and Welch MJ: 64Cu-labeled folate-conjugated shell cross-linked nanoparticles for tumor imaging and radiotherapy: Synthesis, radiolabeling and biological evaluation. J. Nucl. Med. 2005, 46, 1210-1218.

12. Ruangma A, Bai B, Lewis JS, Sun X, Welch MJ, Leahy R, Laforest R: Three-dimensional Maximum a Posteriori (MAP) Imaging with Radiopharmaceuticals Labeled with Three Cu Radionuclides. Nucl. Med. Biol. 2006, 33, 217-226.

Peer-Reviewed Publications Since Joining UT Southwestern* denotes co-senior authors

13. Chong H-S, Mhaske S, Lin M, Bhuniya S, Song HA, and Sun X: Novel bimodal ligands of 64Cu for targeted PET imaging and radiotherapy. Bioorg. Med. Chem. Lett., 2007, 17, 6107-6110.

14. Fan J, Stanfield J, Guo Y, Karam JA, Frenkel E, Sun X, and Hsieh J-T: Effect of trans-2, 3-dimethoxycinnamoyl azide (DMCA) on enhancing anti-tumor activity of Romidepsin on human bladder cancer. Clin. Cancer Res., 2008, 14(4): 1200-1207.

Peer Reviewed Publications (cont’d) * denotes co-senior authors

15. Vasalatiy O, Gerard R, Zhao P, Sun X, and Sherry AD: Labeling of Adenovirus Particles with PARACEST Agents. Bioconjugate Chem., 2008, 19(3), 598-606.

16. Kalman FK, Baranyai Z, Toth I, Banyai I, Kiraly R, Bruecher E, Aime S, Sun X, Sherry AD, and Kovacs Z: Synthesis, Potentiometric, Kinetic, and NMR Studies of 1,4,7,10-Tetraazacyclododecane-1,7-bis(acetic

Sun CV 9

acid)-4,10-bis(methylenephosphonic acid) (DO2A2P) and its Complexes with Ca(II), Cu(II), Zn(II) and Lanthanide(III) Ions. Inorg. Chem., 2008, 47(9), 3851-3862.

17. Lim J, Guo Y, Rostollan CL, Stanfield J, Hsieh J-T , Sun X*, and Simanek EE*: The Role of the Size and Number of Polyethylene Glycol Chains in the Biodistribution and Tumor Localization of Triazine Dendrimers. Mol. Pharm., 2008, 5(4), 540-547.

18. Liu W, Hajibeigi A, Lin M, Rostollan CL, Kovacs Z, Öz OK, and Sun X: An osteoclast-targeting agent for imaging and therapy of bone metastasis. Bioorg. Med. Chem. Lett., 2008, 18, 4789-4793.

19. Woods M, Caravan P, Geraldes CFGC, Greenfield MT, Kiefer GE, Lin M, McMillan K, Prata MIM, Santos AC, Sun X, Wang J, Zhang S, Zhao P, and A. Dean Sherry AD: The Effect of the Amide Substituent on the Biodistribution and Tolerance of Lanthanide(III) DOTA-Tetraamide Derivatives. Invest. Radiol. 2008, 43(12), 861-870.

20. Zhou Y, Gulaka P, Zhou J, Xiao M, Xu D, Hsieh J-T, Kodibagkar V, and Sun X: Preparation and Evaluation of a Radioisotope-incorporated Iron Oxide Core/Au Shell Nanoplatform for Dual Modality Imaging. J. Biomed. Nanotechnol. 2008, 4, 474-481.

21. Pasha A, Lin M, Tircsó G, Woods M, Garry E. Kiefer GE, Sherry AD, and Sun X: Synthesis and biological evaluation of lanthanide ion DOTA-tetraamide complexes bearing peripheral hydroxyl groups. J. Biol. Inorg. Chem. 2009, 14(3), 421-438.

22. Li S, McGuire MJ, Lin M, Liu Y-H, Oyama T, Sun X, and Brown KC: “Synthesis and Characterization of a High Affinity αvβ6-Specific Ligand for In Vitro and In Vivo Applications” Mol Cancer Ther. 2009, 8(5), 1239-1249.

23. Liu J, Hajibeigi A, Ren G, Lin M, Siyambalapitiyage W, Liu Z, Simpson E, Parkey RW, Sun X, and Oz OK: Retention of the radiotracers 64Cu-ATSM and 64Cu-PTSM in human and murine tumors is influenced by MDR1 protein expression. J. Nucl. Med. 2009, 50(8), 1332-1339.

24. Liu W, Hao G, Long LA, Anthony T, Hsieh J-T, and Sun X: Imparting Multivalency to a Bifunctional Chelator: A Scaffold Design for Targeted PET Imaging Probes. Angew. Chem. Int. Ed., 2009, 48(40): 7346-7349.

25. Lim J, Abdellatif Chouai A, Su-Tang Lo S-T, Liu W, Sun X, and Simanek EE: Design, Synthesis, Characterization, and Biodistribution of Triazine Dendrimers Bearing Paclitaxel linked by Ester and Ester/Disulfide Linkages. Bioconjugate Chem., 2009, 20(11), 2154-2161.

26. Xiao M, Nyagilo1 J, Arora V, Kulkarni P, Xu D, Sun X, Davé DP: Gold Nanotags for Combined Multi-Colored Raman Spectroscopy and X-Ray Computed Tomography. Nanotechnol, 2010, 21(3):035101/1-035101/8

27. Xie D, Gore C, Liu J, Pong, RC, Mason, RP, Hao G, Long M, Kabbani W, Yu L, Zhang H, Chen H, Sun X, Boothman DA, Min W, and Hsieh JT: Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis. Proc. Natl. Acad. Sci. USA, 2010, 107(6): 2485-2490.

28. Huang C, Hao Y, Nyagilo J, Dave, DP, Xu L, and Sun X: Porous hollow gold nanoparticles for cancer SERS imaging. J. Nano Res., 2010, 10: 137-148

Peer Reviewed Publications (cont’d) * denotes co-senior authors29. Lo S-T, Stern S, Clogston JD, Zheng J, Adiseshaiah PP, Dobrovolskaia M, Lim J, Patri A*, Sun X*, and

Eric E. Simanek EE*: Biological Assessment of Triazine Dendrimers as Candidate Platforms for Nanomedicine: Toxicological Profiles, Solution Behavior, Biodistribution, and Drug Release and Efficacy in a PEGylated, Paclitaxel Construct. Mol. Pharm., 2010, 7:993-1006.

30. De Leon-Rodriguez LM, Lubag A, Udugamasooriya DG, Proneth B, Brekken RA, Sun X, Kodadek T, and Sherry AD: MRI Detection of VEGFR2 in Vivo Using a Low Molecular Weight Peptoid-(Gd)8-Dendron for Targeting. J. Am. Chem. Soc., 2010, 132(37):12829-12831

31. Drerup JM, Hayashi K, Huxing Cui H, Mettlach GL, Long MA, Marvin M, Sun X, Goldberg MS, Lutter M, and Bibb JA: Attention-Deficit/Hyperactivity Phenotype in Mice Lacking the Cyclin-dependent Kinase 5 Cofactor p35. Biological Psychiatry, 2010, 68(12): 1163-1171.

32. Dence CS, Laforest R, Sun X, Sharp TL, Welch MJ, and Mach RH: Radiochemical synthesis, rodent biodistribution and tumor uptake, and dosimetry calculations of [11C]methylated LY2181308. Mol. Imaging Biol. 2010, 12:608-615.

33. Huang C, Jiang J, Muangphat C, Sun X, and Hao Y: Trapping iron oxide into hollow Au nanoparticles. Nanoscale Research Letters. 2010, 6(1), 1-5. DOI: 10.1007/s11671-010-9792-x.

34. Karam JA, Huang S, Fan J, Stanfield J, Schultz RA, Pong R-C, Sun X, Mason RP, Xie X-J Niu G, Chen X, Eugene P, Frenkel EP, Sagalowsky AI, and Hsieh JT: Upregulation of TRAG3 gene in urothelial carcinoma of the bladder. Int. J. Cancer. 2011, 128(12), 2823-2832.

35. Suriamoorthy P, Zhang X, Hao G, Joly AG, Singh S, Hossu M, Sun X, and Chen W: Folic acid-CdTe Sun CV 10

quantum dot conjugates and their applications for cancer cell targeting. Cancer Nano. 2011, 1: 19-28.36. Zhou C, Long MA, Qin M, Sun X*, and Zheng J*: Luminescent Gold Nanoparticles with

Efficient Renal Clearance. Angew. Chem. Int. Ed. 2011, 50(14), 3168-3172.37. Shen J, Tsai Y-T, DiMarco N, Sun X, and Tang L: Transplantation of mesenchymal stem

cells from younger donors delayed osteoporosis in old mice. Scientific Reports, 2011, 1(67):1-7

38. Hao G, Hajibeigi A; León-Rodríguez, LMD, Öz OK*; and Sun X*: Peptoid-based PET Imaging of Vascular Endothelial Growth Factor Receptor (VEGFR) Expression. Am. J. Nucl. Med. Mol. Imaging, 2011, 1(1): 65-75 (Highlighted a dedicated Editor’s Perspective essay)

39. Singh AN, Liu W, Hao G, Kumar A, Gupta A, Öz OK, Hsieh J-T, and Sun X: Multivalent Bifunctional Chelator Scaffolds for Gallium-68 Based Positron Emission Tomography Imaging Probe Design: Signal Amplification via Multivalency. Bioconjugate Chem. 2011, 22(8): 1650-1662.

40. Hao G, Zhou J, Guo Y, Long MA, Anthony T, Stanfield J, Hsieh, J-T, and Sun X: A cell permeable peptide analog as a potential specific PET imaging probe for prostate cancer detection. Amino Acids. 2010, in press.

41. Zhou J, Liu W, Pong RC , Hao G, Sun X, and Hsieh JT: Analysis of oligo‐arginine cell‐permeable peptides uptake by prostate cells. Amino Acids. 2011, in press. DOI:10.1007/s00726‐010‐0817‐7

42. Peng F, Lutsenko S, Sun X, and Muzik O: Positron Emission Tomography of Copper Metabolism in the Atp7b−/− Knock-out Mouse Model of Wilson’s Disease. Mol. Imaging Biol. 2011, in press.

43.Peng F, Lutsenko S, Sun X and Muzik O: Imaging Copper Metabolism Imbalance in Atp7b -/- Knock-out Mouse Model of Wilson’s Disease with PET-CT and Orally Administered 64CuCl2. Mol. Imaging Biol. 2012, in press.

44. Marin-Valencia I, Cho SK, Mashimo T, Good LB, Jindal A, Hatanpaa KJ, Vemireddy V, Payal Kapur P, Rakheja D, Sun X, Mickey B, Pascual JM, Choi C, Takahashi M, Togao O, DeBerardinis RJ, Maher EA, Malloy CR and Bachoo RM: Glucose metabolism via the pentose phosphate pathway, glycolysis and citric acid cycle in an orthotopic mouse model of human brain tumors. NMR in Biomedicine, 2012, in press

45. Lim J, Lo ST, Hill S, Pavan GM, Sun X* and Simanek EE*: Antitumor Activity and Molecular Dynamics Simulations of Paclitaxel-Laden Triazine Dendrimers. Molecular Pharmaceutics. 2012, 9(3): 404-412

46. Zhou C, Hao G, Thomas P, Liu J, Yu M, Sun S, Öz OK, Sun X* , and Zheng J*: Near Infrared Emitting Radioactive Gold Nanoparticles with Small-molecule-like Pharmacokinetics. Angew. Chem. Int. Ed., 2012, in press

47. Vasdev N , Cao P , van Oosten EM , Wilson AA, Houle S, Hao G, Sun X, Slavine N, Alhasan M, Antich PP, Bonte, FJ, and Kulkarni P: Synthesis and PET imaging studies of [18F]2-fluoroquinolin-8-ol ([18F]CABS13) in transgenic mouse models of Alzheimer’s disease. Med. Chem. Commun., 2012, DOI:10.1039/C2MD20075A

Reviews, Chapters, Monographs and Editorials

1. Sun X, Anderson CJ: Production and Applications of Copper-64 Radiopharmaceuticals. Imaging in Biological Research, Methods in Enzymology, 2004; 386:237-261.

2. Lin X, Lubag A, McGuire MJ, Seliounine SY, Tsyganov EN, Antich PP, Sherry AD, Brown KC, and Sun X: Advances in molecular imaging of pancreatic beta cells. Frontiers in Bioscience, 2008, 13, 4558-4575.

3. Hao G, Singh A, Liu W, and Sun X: PET with Non-Standard Nuclides. Curr Top Med Chem. 2010, 10(11): 1096-1112. PMID: 20388114

4. Hao G, Singh A, Oz OK, and Sun X: Recent Advances in Copper Radiopharmaceuticals. Curr Radiopharm. 2011, 4, 109-121.

5. Jin W, Hao G, Sun X and Chen W: Nanoparticle-based Nuclear Imaging of Cancer. Reviews in Nanosciences and Nanotechnology, 2011, in press.

Books/Textbooks

Sun CV 11

1. Chen W, and Sun X: Luminescent Nanoparticles for Biological Applications: Imaging, Therapy, and Targeting Strategies. Recent Advances of Bioconjugate Chemistry in Molecular Imaging. Chapter 20, p1-59; Publisher: Research Signpost; ISBN: 978-81-308-0210-7, 2008

2. Wu Y, Sun X, and Sherry AD: Molecular Imaging and Cancer Management: PET and MR Agents for Molecular Imaging of Cancer Metabolism. Chapter 20 of “Principles of Molecular Diagnostics and Personalized Cancer Medicine”. Edited by Dr. Tan and Dr. Lynch. Published by Wolters Kluwer Health--Lippincott Williams & Wilkins, 2012

Case Reports N/A

Letters to the Editor N/A

Proceedings of Meetings (Since 2007)

1. Mai Lin, Azhar Pasha, Mark Woods, A. Dean Sherry, Garry E. Kiefer, Sun, X: in Vivo Evaluation of Three 177Lu-Labeled Novel Tetraazacyclododecane-Based Ligands Differing in the Numbers of Peripheral Hydroxymethyl Groups. J. Label. Compd. Radiopharm. 2007, 50(S1), S457

2. OK. Oz, G. Ren, A. Hajibeigi, W. Siyambalapitiyage, M. Lin and Sun, X: Genetic background influences hepatic retention of 64Cu-ATSM and 64Cu-PTSM. J. Nucl. Med. 2007, 48(S): 253-75P

3. W. Liu, A. Hajibeigi, C. Siyambalapitiyage, M. Lin, C. Rostollan, O. K. Oz, Z. Kovacs, and Sun, X: Novel osteoclast-targeting agents for bone metastasis. J. Nucl. Med. 2008, 49(S1):1264-297P

4. M. Lin, S. Li, M. J. McGuire, K. C. Brown, and Sun, X: Effects of PEGylation and DOTA conjugation sites on v6 targeting peptide conjugates. J.Nucl. Med. 2008, 49(S1): 381-96P

5. J.-M. Ahn, E. Murage, M. Lin, Sun, X, G. Gao, and A. Bisello: Development of Enzymatically Stable GLP-1 Analogues for Imaging Pancreatic Beta-Cells. The 4th NIH/JDRF Beta Cell Workshop, April 6 – 7, 2009, Washington, DC.

6. M. Lin, E. Murage, A. Lubag, M. Long, A. D. Sherry, J.-M. Ahn, and Sun, X: Novel GLP-1 Peptide Analogs for PET Imaging of Pancreatic β-Cell Mass. The 4th NIH/JDRF Beta Cell Workshop, April 6 – 7, 2009, Washington, DC.

7. M. Lin, Z. Liu, M. McGuire, S. Li, X. Chen, K. Brown, and Sun, X: A 68Ga-Labeled Peptide for Imaging of v6 Positive Tumor. J. Nucl. Med. 2009, 50(S2), 129P

8. J. Liu, A. Hajibeigi, M. Lin, Sun, X. Lin, and O. Oz: Genetic background difference in murine hepatic retention of 64Cu-ATSM is associated with different expression of multidrug resistance protein 3. J. Nucl. Med. 2009, 50(S2), 71P

Proceedings of Meetings (Since 2007) (cont’d)

9. M. Xiao, J. O. Nyagilo, M. Long, D. Xie, J.-T. Hsieh, D. Xu, D. P. Davé, and Sun, X: Gold Nanotags for Dual-Modality Imaging of Cancer. The World Congress of Molecular Imaging, September 23 – 26, 2009, Montreal, Canada

10. G. Hao, L. M. De Leon-Rodriguez, M. Long, R. Brekken, A. D. Sherry, and Sun, X: Peptoid-based PET Imaging Probes: A Pilot Study with a VEGFR2 Specific Ligand. The World Congress of Molecular Imaging, September 23 – 26, 2009, Montreal, Canada

11. S.-T. Lo, M. Lin, M. Long, E. Murage, A. D. Sherry, J. –M. Ahn, and Sun, X: Targeting GLP-1R for PET Imaging of Pancreatic β Cell Mass Using 68Ga-labeled GLP-1 Peptide Analogs. The World Congress of Molecular Imaging, September 23-26, 2009. Montreal, Canada

12. Hao G, Du Y, Long M, Oz OK, Mohan C, Sun X: Imaging of Spontaneous Lupus Nephr-

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itis by FDG-PET in an Anti-GBM Nephritis Mouse Model. J Nucl Med 2010, 51(S2), 101P

13. Hao Y, Huang C, Nyagilo J, Dave D, Xu L, Sun X: Synthesis, characterization and properties of porous hollow Au nanoparticles Abstracts of Papers, 240th ACS National Meeting, Boston, MA, United States, August 22-26, 2010, COLL-13.

14. Simanek EE, Sun X, Lo S-T Lim J: Paclitaxel-triazine dendrimer constructs: Efficacy, toxicity and characterization Abstracts of Papers, 240th ACS National Meeting, Boston, MA, United States, August 22-26, 2010, PMSE-131.

15. Ahn JM, Murage EN, Lin M, Lo S-T, and Sun X: Development of Highly Constrained GLP-1 Analogues as PET Imaging Agents for Assessing Pancreatic Beta-Cell. Pre-Congress Symposium on Beta-Cell Imaging, Stockholm, Sweden, September 19, 2010.

16. Kulkarni PV, Vasdev N, Hao G, Arora V, Long M, Slavine N, Chiguru S, Qu BX, Sun X, Bennett M: A New F-18 Labeled PET Agent For Imaging Alzheimer's Plaques. AIP Conference Proceedings. 2011, 1336, 383-385

17. Hao G, Hajibeigi A, De Leon LM, Oz OK, and Sun X: Visualization of VEGRFR2 Expression in Salivary Glands by a 64Cu-labeled Peptoid Analog. J Nucl Med 2011, 52 (S1), 338P

18. Kulkarni PV, Arora V, Chiguru S, Hao G, Gupta A, Slavine, NV, Vasdev N, Sun X, Antich P, Bonte FJ: PET Imaging of Early Stages of Alzheimer’s Disease (AD) in Trangenic Mice with F-18 Hydroxy Quinoline. J Nucl Med, 2011, 52(S1), 226P

19. Hao G, Singh AN, Gore C, Pong R, Hsieh JT, Sun X: Presenting a Cell Permeable Peptide on a Chelator Scaffold for PET Imaging of Prostate Cancer. J Nucl Med 2011, 52 (S1), 139P

20. Gao HK, Niu G, Yang M, Quan Q, Ma Y, Ahn J, Sun X, Kiesewetter D, Chen X: PET Imaging of Insulinoma using 18F-FBREM-EM3106B, a New GLP-1 Analog. J. Nucl. Med. 2011, 52 (S1), 123P

21. Singh AN, Li S, Hao G, Gupta A, McGuire MJ, Brown KC, and Sun X: Novel PET Probes for Molecular Imaging of the αvβ6 integrin. J Nucl Med 2011, 52 (S1), 89P

22. Kulkarni PV, Vasdev N, Arora V, Hao G, Long MA, Slavine NV, Qu B, Sun X, Antich P, Bonte FJ: PET Imaging of Alzheimer’s Disease (AD) Trangenic Mice with an F-18-labeled Hydroxy Quinoline Derivative. J Nucl Med, 2011, 51(S2), 367P.

23. Lo S-T, Murage E, Ahn J, and Sun X: PET Imaging of Pancreatic Beta-Cell Mass Changes in a Mouse Model, J Nucl Med 2011, 52 (S1), 26P

24. Sun X, Singh AN, Liu W, Hao G, Gupta A, Hsieh J-T: Novel Multivalent Bifunctional Chelator Scaffolds for PET Signal Amplification of Prostate Cancer Detection. Innovative Minds in Prostate Cancer Today (IMPaCT) 2011, Orlando, Florida, March 9 – 12, 2011

Proceedings of Meetings (Since 2007) (cont’d)

25. Sun X, Nyagilo J, Dave DP: In Vivo Evaluation of Gold Nanoparticles for Potential Multimodality Imaging of Cancer. The 20th International Materials Research Congress, Cancun, Mexico, August 13 – 19, 2011.

Clinical Practice Guidelines N/A

Non-peer reviewed scientific or medical publications/materials in print or other media N/A

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CURRENT EXTRAMURAL FUNDING

Grant Number: 37-2011-20; OSP ID100466 (Ahn/Sun) 11/01/2010 – 10/31/2012Funding Agency: Juvenile Diabetes Research Foundation International Title of Proposal: Non-Invasive Imaging of Pancreatic Beta Cells Using Novel GLP-1 ConstructsProject Goal: To develop novel PET probes by using conformationally constrained GLP-1 analogues with high enzyme stability and to determine pancreatic beta-cell massRole: Co-Principal Investigator

Grant Number: NIH 1 R01 DK092163-01 (MPI: Sun/Oz) 09/01/2011 – 08/30/2016Funding Agency: National Institutes of HealthProject Title: Noninvasive Assessment of Pancreatic Beta-Cell MassProject Goal: To develop a practical PET-CT imaging approach with clinically acceptable accuracy and reproducibility for noninvasive assessment of pancreatic beta-cell mass.Role: Principal Investigator

Grant Number: RP110771 (Sun) 08/01/2011 – 07/31/2016Funding Agency: Cancer Prevention Research Institute of TexasProject Title: Acquisition of Biomedical Cyclotron and Development of Comprehensive Positron Emission Tomography Program at UT Southwestern for Cancer Research Project Goal: To acquire a biomedical cyclotron and develop a comprehensive PET program for cancer research projects at UT Southwestern.Role: Principal Investigator

Grant Number: NIH R01CA159144-01 (Hsieh) 09/30/2011 – 08/29/2016Funding Agency: National Institutes of Health

Project Title: Targeting Aggressive Prostate Cancer with Novel Theranostic NanomedicineProject Goal: To construct dendrimer-based nanoconjugates presenting three functional molecules for prostate cancer treatment.Role: Co-Investigator

Grant Number: RP120588 (Zheng/Sun) 12/01/2011 – 11/30/2014Funding Agency: Cancer Prevention Research Institute of TexasProject Title: Targeting Tumor Microenvironment for Cancer Imaging and Therapy: Renal Clearable and pH Responsive Gold Nanoparticles Project Goal: To design and synthesize a gold nanoparticle-based system for cancer detection and treatment by targeting the tumor microenvironment. Role: Co-Principal Investigator

Grant Number: RP110549 (Ward) 07/01/2011 – 06/30/2016Funding Agency: Cancer Prevention Research Institute of TexasEngineering Anti-Phosphatidylserine Antibodies for Cancer TherapyProject Goal: To develop a novel immunotherapy for cancer. Role: Co-Investigator

Grant Number: 37-2011-632 (Sun/Oz) 05/01/2012 – 04/30/2014Funding Agency: Juvenile Diabetes Research Foundation International Noninvasive PET Assessment of Pancreatic Beta-Cell Mass and Function Project Goal: To develop a noninvasive imaging technique for the assessment of beta-cell function (BCF) in the context of gradual loss of beta-cell mass (BCM) during the type I diabetes progression.Role: Principal Investigator

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Grant Number: NIH R01 EB014244-01A1 (MPI: Brown/Sun) 09/01/2012 – 08/31/2017Funding Agency: National Institutes of HealthProject Title: Multi-Layered Valency: Novel Design of Peptidic Imaging Agents for v6 Project Goal: To construct multi-valent PET imaging probes that target integrin v6 for non-small cell lung carcinomaRole: Principal Investigator

Grant Number: DOD-PC111721 (PI: Sun; Partner PIs: Hsieh/Simanek) 09/01/2012 – 08/31/2017Funding Agency: Department of Defense – PCRP Synergistic Idea AwardProject Title: Molecular Innovations toward Theranostics of Aggressive Prostate Cancer (PC111721)Project Goal: To construct biocompatible theranostic agents containing specific targeting molecules, therapeutic agents, and an imaging moiety for detection and therapy of advanced prostate cancerRole: Principal Investigator

XII. PROJECTS COMPLETED

Grant Number: W81XWH-11-1-0188 (Peng) 06/01/2011 – 05/31/2012Funding Agency: Department of Defense Novel Approaches for Eradication of Circulating Breast Cancer CellsProject Goal: To design and synthesize a novel targeted structure for the detection and eradication of blood circulation breast cancer cells.Role: Co-Investigator

Grant Number: W81XWH-08-1-0305 05/01/2008 – 04/30/2012 Funding Agency: Department of Defense Project Title: Specific PET Imaging Probes for Early Detection of Prostate Cancer MetastasesGoals: To develop a novel group of imaging probes for the detection of multi-foci prostate cancer metastases before any symptoms occur, prompting the early treatment that could potentially prevent prostate cancer from developing to lethal stages, thus diminishing the deaths resulted from prostate cancer bone metastases or related complications. Role: Principal Investigator

Grant Number: NIH U24 CA126608-01 (MPI: Mason/Sherry) 03/01/2007 – 02/28/2012Funding Agency: National Institutes of Health Project Title: UT Southwestern Small Animal Imaging Resource Goals and Aims: The SW-SAIR will provide centralized coordination and integration of expertise and imaging infra- structure. It will also foster development and implementation of enhanced imaging technologies and organize training of investigators in the science and art of imaging.Role: Core Director, Technical Committee Member

Grant Number: NIH R01 GM064560-05 (Simanek) 09/01/2006 – 08/31/2011 Funding Agency: National Institutes of HealthProject Title: Molecular Recognition in Dendrimers Based on Melamine Goals: To study the mechanisms of drug association and delivery in the dendrimer systems so as to understand the effects of dendrimers’ size, shape, and composition on their biological behavior and potential applications in cancer treatments.Role: Co- Investigator with a Subcontract with Texas A&M

Grant Number: NIH P01 DK058398-06 (Newgard) 09/01/2006 – 08/31/2011

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Funding Agency: National Institutes of HealthProgram Project Title: Development of Novel Therapies for NIDDM Project 2: Targeted responsive MR and PET agents for beta-cell imaging (Sherry)Goals (Project 2): To develop novel targeted imaging agents for the assessment of pancreatic beta cells by MRI and PET. Role: Co-Principal Investigator of Project 2

A Research contract with Alnylam Pharmaceuticals, Cambridge, MA 11/01/2006 – 10/31/2011Project: Evaluation of siRNAs in diseased animal modelsRole: Principal Investigator

Grant Number: 5 RC1 AG036308-02 (Kulkarni) 09/30/2009 – 08/31/2011Funding Agency: NIH - ARRA Stimulus Challenge GrantNovel PET Imaging Agents for Early Diagnosis of Plaque Deposition in Alzheimer's Disease.Project Goal: Develop biomarkers for the early detection of amyloid plaques in living humans allowing for specific and accurate diagnosis, tracking of disease progression and modification of treatments.Role: Co- Investigator

Grant Number: DOD W81XWH-05-1-0592 (Sun) 09/15/2005 – 09/14/2009 Funding Agency: Department of Defense Project Title: PSMA-Targeted Nano-Conjugates as Dual-Modality (MRI/PET) Imaging Probes for the Noninvasive Detection of Prostate CancerGoals: To synthesize and characterize PSMA-targeted nano-conjugates; evaluate in vivo behavior of the nanoconjugates in normal and prostate tumor bearing mice; and apply the nanoconjugates to noninvasive MRI/PET imaging of prostate cancer. Role: Principal Investigator

Grant Number: NIH R21 CA119219 (Sun) 08/01/2006 – 07/31/2009 Funding Agency: National Institutes of HealthProject Title: Novel Agents for Detecting/Monitoring of Bone MetastasisGoals: To synthesize a new type of macrocyclic bone-seeking agents with methylene-phosphonate or bisphosphonate motif, and evaluate their applications for noninvasive imaging of bone metastases. Role: Principal Investigator

Bradley-Alavi Fellowship from the Society of Nuclear Medicine (Lin) 2006Title: Targeted PET Imaging of Lung Cancer via a Tetrameric PeptideRole: Mentor

A Pilot Research Award from the Society of Nuclear Medicine 03/01/2005–08/31/2006Title: Preparation of 74As-doped Fe2O3 nano-scaffolds as multi-modality imaging probesRole: Principal Investigator

An American Cancer Society-Institutional Research Grant 11/01/2004-10/31/2005Title: A 177Lu complex for bone metastasis treatmentRole: Principal Investigator

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