Z. Kamberska Varenna, 18.10.2007 Report from the Czech Republic EUROCHIP 2

Z. Kamberska Varenna, 18.10.2007

Report from the Czech Republic

EUROCHIP 2


Activities within Eurochip 2

• 1) Calculation of 5 year survival by region; in different regions by most frequent diagnoses

• 2) Calculation of 5 year survival of women with dg C50, with x without radiotherapy after surgery

• 3) Test of statistical correlation between MN and life style (data from HIS in CR)

• 4) Participation in Pilot Studies


Differences between regions

• Each region has “good“ and “bad“ survival rates in different diagnoses

• We could not find “better” and “worse regions”• Only Prague Region is the best in all diagnoses


Five year survival rate of dg. C18 – C21 females


Five year survival rate of dg. C18-C21 - men


Five year survival rate of dg. C50


Five year survival rate of dg C34 -men


Five year survival rate of all MN men

Five year survival rate of all MN females


Calculation of survival rate after surgery (dg C50)

Statistically highly significant difference in survival was only found in stage 1, already on level 0.1 %. On the contrary, in higher stages (2 – 4) radiotherapy has no statistically significant influence on the probability of survival.


0% 20% 40% 60% 80% 100%

stage 1 - with radiotherapy

stage 1 - no radiotherapy

stage 2 - with radiotherapy

stage 2 - no radiotherapy

stage 3+4 - with radiotherapy

stage 3+4 - no radiotherapy

Five-Year-Surviving of Women With Cancer of Breast (dg.C50)

survived deceased


Basic Data from HIS CR

HIS CR YEAR MN NO MN YES TOTAL1993 1591 9 16001996 3365 31 33961999 2339 16 23552002 2434 42 2476

Total 9729 98 9827


0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

HIS respondentswithout cancer

HIS respondentswith cancer

Structure of smoking

never smoked former smoker occasional smokerlight smoker heavy smoker


0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%



Structure of alcohol consumption

exceptional reasonable excessive


0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%



Structure of body mass index

-24.9 kg/m2 25.0-29.9 kg/m2 30.0+ kg/m2


0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%



Structure of dietary index

good moderate bad


Results from HIS CR

Respondents with MN: drink less (5 %)

smoke less (1%)

have better nutrition habits

higher BMI


Problems with Pilot Study

• Conversion of Czech form to form of Pilot Study• Entry of 300 cases according to form is not only

time consuming, but has hight probability of error. It has to be done manually

• Sugestion: to improve data entry – it can be done by computer – but we need structure of record


Problems with Pilot Study

A C

PORC YEAR of Birth Date of f irst visit Date of Dg ZJIPRI DGSTAN DG T TMM N M pT pTmm pN

1 53 19102003 03122003 3 11 C509 1 0 X 1 02 30 26082003 10092003 5 01 C505 2 0 0 2 03 25 05022003 31032003 3 03 C504 2 1 0 2 14 50 14012003 26052003 1 11 C500 1 0 0 1 15 05 45 15052003 16052003 3 11 C509 3 1 X 2 16 34 04082003 18082003 3 11 C504 2 0 0 2 07 50 20032003 30042003 3 03 C509 1 0 0 1 20 18 59 11032003 13032003 3 43 C501 4 50 X 0 4 50 X9 55 12072003 29072003 2 11 C504 2 0 0 2 010 27 20062003 16072003 3 11 C509 2 1 0 2 111 43 16122002 15012003 3 11 C505 1 1 0 1b 1b


Future

• Very difficult situation in our Institute– Number of personnel was cut to one half

– Due to serious problem with results from Eurocare study, we are not allowed to present any data from Cancer Registry until the data are cleared by Board of Czech Oncological Society

I shall be retired at the end of this year and my successor will be Lenka Jurickova

Documents

Z. Kamberska Varenna, 18.10.2007 Report from the Czech Republic EUROCHIP 2