adhere(migration)(differentiation)(proliferation)biorecognitionreceptorligand
adhesion molecules
cadherins(integrins)16724
ECM:collegenECMfibronectinECMproteoglycanlaminin
extracellular matrix,ECMECMligandRGD--
focal adhesions,FAs
protein complexes(cytoskeleton)(ECM)anchoring the celltransmitting signals 10-15nm
(talin)(paxillin)(vinculin)tensinfocal adhesion kinase
actin
tyrosine kinase,Src(focal adhesion kinase)InRNA
migration
focal complex0.25(focal adhesion)
http://www.reading.ac.uk/cellmigration/migration.htm
topography
.
1.Exploring and engineering the cell surface interface .Molly M. Stevens Julian H. George2. Dalby, M. J., et al., Nat. Mater. (2007) 6, 997
Hydrophilicity/Hydrophobicity:();(RGD);Cellsurface interactions of rat tooth germ cells on various biomaterials.Journal of Biomedical Materials Research Part A.
(fanctional group) ;;()
Effects of surface functional groups on protein adsorption and subsequent cell adhesion using self-assembled monolayersYusuke Arim, Hiroo Iwata.
(surface charge) BaldwinNGFInteraction of cells on chargeable functional group gradient surfaces. Jin Ho Lee, Jin Whan Lee etc.