A
Accurate
R
Rapid
E
Effective
Research Products on ImmunoMetabolism
Bioactive hormones and cytokines
Well validated antibodies
Highly sensitive ELISA Kits
2017 Product Catalogue
Website: www.immunodiagnostics.com.hk
E-mail: [email protected]
Tel: (+852) 3502 2780; 5309 1323; 5605 3221
Fax: (+852) 3502 2781
ImmunoDiagnostics
ML-00-00360 Rev 2017b
For Research use Only
Hormonal Immunoassays
Insulin Series (human/mouse/rat) (wide range/high sensitive/ultra sensitive)
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2
3
4
5
FGF21 (human/mouse/rat)
Adiponectin (human/mouse/rat)
FABP4/A-FABP (human/mouse)
Lipocalin-2/NGAL (human/mouse)
Bioactive Hormones and Cytokines
6Hormones, Growth Factors and Cardiometabolic Biomol
About UsImmunoDiagnostics Limited (IMD) is a spin-off biotech company from the Antibody and
Immunoassay Services (AIS, www.antibody.hku.hk), The University of Hong Kong.
The company focuses on ImmunoMetabolism, an emerging field which studies
interplay between immunological and metabolic processes, and has developed a wild
range of products related to this area.
By far, our products have been intensively applied in both basic and clinical studies
worldwide and have been frequently cited in numerous publications with high impact
factors.
Contact Us
Website: www.immunodiagnostics.com.hk
E-mail: [email protected]
Tel: (+852) 3502 2780; 5309 1323; 5605 3221
Fax: (+852) 3502 2781
Address: 5/F, Biotech centre 2, No. 11 Science Park West Avenue, Hong Kong Science Park
ImmunoDiagnostics LimitedWebsite: www.immunodiagnostics.com.hk ; E-mail: [email protected]; Tel: (+852) 3502 2780; Fax: (+852) 3502 2781
Insulin and C-peptide ELISA Kits
1
Publications Citing Our Products:
ImmunoDiagnostics LimitedWebsite: www.immunodiagnostics.com.hk ; E-mail: [email protected]; Tel: (+852) 3502 2780; Fax: (+852) 3502 2781
High sensitive, mouse insulin ELISA kit• So, W. Y., et al. Cell Death Dis. 2015; 6:e1707.
• Liang Q, Zhong L, Zhang J, et al. Diabetes. 2014; 63(12):
4064-4075.
• Cheng, Sam Tsz Wai, et al. PLoS One. 2016; 11(1):e0147391.
Wang, Lin, et al. PLoS One. 2015; 10(6):e0128216.
Wide range, mouse insulin ELISA kit• Lin Z, Pan X, Wu F, et al. Circulation. 2015; 131(21):1861-71.
• Liang Q, Zhong L, Zhang J, et al. Diabetes. 2014; 63(12):
4064-4075.
• So, W. Y., et al. Cell Death Dis. 2015; 6:e1707.
• Wang, Lin, et al. PLoS One. 2015; 10(6):e0128216.
High sensitive, rat insulin ELISA kit• Wang, Lin, et al. Pancreas. 2017; 46(3):395-404.
Ultra sensitive, mouse insulin ELISA kit• Cheng K.K, Lam KS, et al. Proc Natl Acad Sci U S A. 2012;
109(23):8919-24.
• Cheng K.K, et al. Diabetes. 2014; 63(11): 3748-58.
• Shu L, Hoo R L C, Wu X, et al. Nat Commun. 2017;
8:14147.
• Li X, Cheng K. K, Liu Z, et al. Nat Commun. 2016; 7:11740.
• Lin Z, Tian H, et al. Cell Metab. 2013; 17(5):779-89.
• Liang Q, Zhong L, Zhang J, et al. Diabetes. 2014; 63(12):
4064-4075.
• Cheng, Sam Tsz Wai, et al. PLoS One. 2016;
11(1):e0147391.
• So, W. Y., et al. Cell Death Dis. 2015; 6:e1707.
• Wang, Lin, et al. PLoS One. 2015; 10(6):e0128216.
Wide range, rat insulin ELISA kit• Wang, Lin, et al. Pancreas. 2017; 46(3):395-404.
Insulin is a peptide hormone exclusively produced in pancreatic beta-
cells. It consists of a 21-amino acid A chain and a 30-amino acid B chain,
which are linked by two disulfide bridges.
Insulin is the primary hormone responsible for glucose metabolism.
Impaired insulin secretion and insulin resistance are key causes of type 2
diabetes (T2D).
During the maturation of insulin, C-peptide, a short 31-amino acid
polypeptide that connects the A chain and B chain of insulin, is digested
from the proinsulin molecule.
In diabetes and other metabolic disorders, serum C-peptide levels can
be used for distinguishing endogenous insulin secretion level from
exogenous insulin due to pharmaceutical interventions.
ImmunoDiagnostics has developed a series of insulin-related ELISA kits
with various assay ranges and comparable performance to leading
commercial kits in current market.
Human/ Mouse / Rat Insulin ELISA Kits
Based on highly specific monoclonalantibodies
Rapid procedures:
the whole process takes only 90 mins.
Small sample volume
Simplified operation (one step)
Mouse / Rat C-peptide ELISA Kits
Based on highly specific monoclonalantibodies
Small sample volume
Simplified operation
Insulin ELISA Kits Assay Range Cat No.Human Insulin 3 -120 µIU/ml 31380
Wide range mouse Insulin 1 -50 ng/ml 32100
Wide range rat Insulin 1 -50 ng/ml 33100
High sensitive mouse Insulin 0.2 -7 ng/ml 32270
High sensitive rat Insulin 0.2 -7 ng/ml 33270
Ultra sensitive mouse Insulin 0.025-1.5 ng/ml 32380
Ultra sensitive rat Insulin 0.025-1.5 ng/ml 33380
C-peptide ELISA Kits Assay Range Cat No.Mouse c-peptide 0.15 to 2.5 ng/ml 32780
Rat c-peptide 0.15 to 2.5 ng/ml 33780
All products are RUO
Fibroblast Growth Factor 21 (FGF21) FGF21 is a metabolic hormone mainly produced in liver. It regulates glucose and lipid metabolism through
pleiotropic actions in multiple tissues, and protects against metabolic damages under various stresses.
In humans, high circulating FGF21 levels are found in obesity and multiple cardiometabolic disorders,
including metabolic syndrome, type 2 diabetes, non-alcoholic fatty liver disease and coronary artery disease.
Serum FGF21 is a potential biomarker for the early detection and risk prediction of these diseases.
Publications Citing Our Products:
Bioactive proteins and antibodies Cat No.Recombinant FGF21 (Human) 41189
Recombinant FGF21 (Mouse) 42189
Anti-FGF21 pAb (Human) 11180
Anti-FGF21 pAb (Mouse) 12180
ELISA Kits Assay Range Cat No.
Human FGF-21 30-1920 pg/ml 31180
Mouse/Rat FGF-21 31.2-2000 pg/ml 32180
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FGF21
Gluconeogenesis ↑
Cholesterol excretion ↑
Cholesterol biosynthesis ↓
Lipid clearance ↑
Insulin sensitivity ↑
Ceramide accumulation ↓
Browning activity ↑
Glucose uptake ↑Reproduction ↑
Circadian activity ↑
Lipid clearance ↑
Insulin sensitivity ↑
Oxidative stress ↓
Apoptosis ↓
ImmunoDiagnostics has developed a wide range of FGF21-related products for research use, including:
ImmunoDiagnostics LimitedWebsite: www.immunodiagnostics.com.hk ; E-mail: [email protected]; Tel: (+852) 3502 2780; Fax: (+852) 3502 2781
Mouse FGF21 Elisa Kits • Ye D, Wang Y, Li H, et al. Hepatology. 2014; 60(3): 977-989.
• Liang Q, Zhong L, Zhang J, et al. Diabetes. 2014; 63(12):
4064-4075.
• Li H, Gao Z, Zhang J, et al. Diabetes. 2012; 61(4): 797-806.
• So, Wing Yan, et al. Diabetes. 2013; 62(11):3751-9.
FGF21 (mouse), rabbit polyclonal antibody • Liu Y, Palanivel R, Rai E, et al. Diabetes. 2015; 64(1): 36-48.
• Li H, Gao Z, Zhang J, et al. Diabetes. 2012; 61(4): 797-806.
Recombinant mouse FGF21 protein• So, W. Y., et al. Cell Death Dis. 2015; 6:e1707.
• Gong Q, Hu Z, Zhang F, et al. Hepatology. 2016; 64(2): 425-
438.
• So, Wing Yan, et al. Diabetes. 2013; 62(11):3751-9
All products are RUO
Adiponectin is an adipokine exclusively expressed in adipose tissues with potent anti-diabetic, anti-
atherogenic and anti-inflammatory functions.
In humans, decreased serum adiponectin levels are associated with increased body mass index (BMI),
decreased insulin sensitivity, less favourable plasma lipid profiles, increased inflammation and increased
risk for the development of type 2 diabetes, hypertension and coronary heart diseases.
Adiponectin
Publications Citing Our Products:
ELISA Kits Assay Range Cat No.Human Adiponectin 1.55-100 ng/ml 31010
Rapid Human Adiponectin 7.8-500 ng/ml 31012
Mouse/Rat Adiponectin 3.12-200 ng/ml 32010
Immunoturbidimetric(ITA) Assay Assay Range Cat No.
Human Adiponectin 0 - 40 µg/mL 51010
Bioactive proteins and antibodies Cat No.Recombinant Adiponectin (Human) 41013
Recombinant Adiponectin (Mouse) 42011
Anti-Adiponectin MAb (Human), clone Ha6 21010
Anti-Adiponectin MAb (Human), clone Ha7 21011
Anti-Adiponectin pAb (Human) 11010
Anti-Adiponectin pAb (Mouse) 12010
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Adipose tissue
M2 macrophage ↑
Browning activity ↑
CardiomyocyteApoptosis↓
Inflammation↓
Oxidative/Nitrative stress↓
Fatty acid/glucose uptake↑
EPCs
Mobilization↑
Function↑
Senescence↓VSMCs
Proliferation↓
Migration↓
Endothelial Cells
NO production↑
Apoptosis↓
Activation↓
Oxidative stress↓
Inflammation↓
Foam cell formation↓
M1 to M2 polarization↑ Macrophages
Adiponectin
Trimer
Hexamer
High molecular
weight multimer
ImmunoDiagnostics has developed a series of adiponectin-related products, which have been used
globally for over a decade:
ImmunoDiagnostics LimitedWebsite: www.immunodiagnostics.com.hk ; E-mail: [email protected]; Tel: (+852) 3502 2780; Fax: (+852) 3502 2781
Adiponectin (mouse), rabbit polyclonal antibody• Hui X, Gu P, Zhang J, et al. Cell Metab. 2015; 22(2): 279-290.
• Zhang, Xu, et al. Cell Death Differ. 2017; 24(2):225-237.
Recombinant mouse adiponectin protein• Yau S Y, Li A, Hoo R L C, et al. Proc Natl Acad Sci U S
A. 2014; 111(44): 15810-15815.
Mouse Adiponectin Elisa Kits• Dadson K, et al. PLoS One. 2015; 10(4):e0121049.
• Kim A Y, Park Y J, Pan X, et al. Nat Commun. 2015; 6:7585.
• Dang TQ, et al. J Endocrinol. 2017; 234(2):101-114.
• Hui X, Gu P, Zhang J, et al. Cell Metab. 2015; 22(2): 279-290.
• Li J, Lin S, Vanhoutte P M, et al. Circulation. 2016;
133(24):2434-46.
• Lin Z, Pan X, Wu F, et al. Circulation. 2015; 131(21):1861-71.
• Shu L, Hoo R L C, Wu X, et al. Nat Commun. 2017; 8:14147.
• Lin Z, Wu F, Lin S, et al. J Hepatol. 2014; 61(4): 825-831.
• Yau S Y, Li A, Hoo R L C, et al. Proc Natl Acad Sci U S
A. 2014; 111(44): 15810-15815.
• Li H, Yao W, Liu Z, et al. Diabetes. 2016; 65(4): 942-955.
• Zhang, Xu, et al. Cell Death Differ. 2017; 24(2):225-237.
All products are RUO
Fatty Acid Binding Protein 4 (FABP-4/A-FABP)
ELISA Kits Assay Range Cat No.
Human A-FABP 0.39-25 ng/ml 31030
Bioactive proteins and antibodies Cat No.Recombinant A-FABP (Human) 41030
Recombinant A-FABP (Mouse) 42030
Anti-A-FABP pAb (Human) 11030
Anti-A-FABP mAb (Human) 21030
Anti-A-FABP pAb (Mouse) 12030
FABP-4, also termed adipocyte fatty-acid binding protein (A-FABP) or AP2, has been shown to play a
key role in obesity and metabolic syndrome. A-FABP knockout mice are substantially protected from insulin
resistance, dyslipidemia, type 2 diabetes and fatty liver disease, despite of increased adipocity.
In clinical studies, increased circulating A-FABP levels are found in obese subjects and associated with
non-alcoholic fatty liver disease, stroke, and carotid atherosclerosis.
ImmunoDiagnostics LimitedWebsite: www.immunodiagnostics.com.hk ; E-mail: [email protected]; Tel: (+852) 3502 2780; Fax: (+852) 3502 2781
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• Non-esterified fatty acids release↑
• Lipolysis↑
• Insulin resistance↑
• Inflammation↑
A-FABPAdipose Tissue
A-FABP
A-FABP
A-FABP
A-FABP
A-FABP
• Cholesterol accumulation↑
• Triglyceride accumulation↑
• ER stress↑
• Inflammation↑
Macrophages
A-FABP
A-FABPA-FABP A-FABP
A-FABP
Circulation
A-FABPA-FABP
A-FABP
• Correlation with
cardiometabolic
syndromes
ImmunoDiagnostics team is the first to discover the circulating form of A-FABP, and has developed a
wide range of related products used worldwide:
All products are RUO
Lipocalin-2 /NGAL
ELISA Kits Assay Range Cat No.Human Lipocalin-2 0.39–25 ng/ml 31050
Mouse Lipocalin-2 0.15-10 ng/ml 32050
Immunoturbidimetric(ITA) Assay Assay Range Cat No.
Human Lipocalin-2 0 - 5000 ng/ml 51300
Bioactive proteins and antibodies Cat No.Recombinant Lipocalin-2 (Human) 41050
Recombinant Lipocalin-2 (Mouse) 42050
Anti-Lipocalin-2 pAb (Human) 11050
Anti-Lipocalin-2 pAb (Mouse) 12050
Anti-Lipocalin-2 MAb (Human), clone 2G1 21050
Anti-Lipocalin-2 MAb (Human), clone 2C3 21051
Lipocalin-2, also known as neutrophil gelatinase-associated lipocalin (NGAL), 24p3, siderocalin, or
neutrophil lipocalin (NL), is a secretory glycoprotein expressed in liver, lung, kidney, adipocytes, activated
neutrophils and macrophages.
Lipocalin-2 is upregulated under various inflammation and infection conditions and can be served as a
sensitive biomarker for various renal injuries. Serum levels of lipocalin-2 are positively correlated with
obesity, insulin resistance, hyperglycemia, coronary heart disease and fatty liver disease in humans.
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Lipocalin-2
• Acute kidney injury
• Acute renal failure
• Chronic kidney injury
• Pancreatitis
• Pancreatic cancer
• Toxin damage
• Acute respiratory distress
• Gastric cancer
• Rheumatoid arthritis
• Mild cognitive impairment
• Depression
• Multiple sclerosis tumor
• HCC, NASH, ASH, FLD
• Fibrosis/cirrhosis
• Acute heart failure
• Hypoxia
• Cardiomyocyte apoptosis
ImmunoDiagnostics team is the first to report lipocalin 2 as a biomarker for metabolic inflammation and
insulin resistance, and has developed a series of related products:
Publications Citing Our Products:
ImmunoDiagnostics LimitedWebsite: www.immunodiagnostics.com.hk ; E-mail: [email protected]; Tel: (+852) 3502 2780; Fax: (+852) 3502 2781
Mouse lipocalin-2 Elisa KitsSong E, et al. J Am Heart Assoc. 2014 Apr 10;3(2):e000837.
Recombinant mouse lipocalin-2 protein• Ye, Dewei, et al. J Hepatol. 2017; 66(3):669.
• Ye, Dewei, et al. J Hepatol. 2016; 65(5):988-997.
All products are RUO
ELISA AssaysProduct Assay Range Cat No.Insulin ELISA kits
Human Insulin 3 -120 µIU/ml 31380
Wide range mouse Insulin 1 -50 ng/ml 32100
Wide range rat Insulin 1 -50 ng/ml 33100
High sensitive mouse Insulin 0.2 -7 ng/ml 32270
High sensitive rat Insulin 0.2 -7 ng/ml 33270
Ultra sensitive mouse Insulin 0.025-1.5 ng/ml 32380
Ultra sensitive rat Insulin 0.025-1.5 ng/ml 33380
Adiponectin ELISA kits
Human adiponectin 1.55-100 ng/ml 31010
Rapid Human adiponectin 7.8-500 ng/ml 31012
Mouse adiponectin 3.12-200 ng/ml 32010
Fibroblast growth factor 21 (FGF-21) ELISA kits
Human FGF-21 30-1920 pg/ml 31180
Mouse FGF-21 31.2-2000 pg/ml 32180
Fatty-acid binding protein 4 (FABP4/A-FABP) ELISA kits
Human fatty-acid binding protien 4 0.39-25 ng/ml 31030
Lipocalin-2/NGAL ELISA kits
Human lipocalin-2 0.39-25 ng/ml 31050
Mouse lipocalin-2 0.15-10 ng/ml 32050
Neutrophil Serine Proteases ELISA kits
Human neutrophil elastase (NE) 0.156-10 ng/ml 31330
Human Proteinase 3 (PR3) 0.156-10 ng/ml 31300
Mouse Proteinase 3 (PR3) 0.1-6.4 ng/ml 32300
Other ELISA Kits
Human FGF-19 31.2-2000 pg/ml 31200
Human alpha 1 antitrypsin (A1AT) 0.312-20 ng/ml 31420
Human C-reactive protein 0.78-50 ng/ml 31220
Rapid Human C-reactive protein 0.78-50 ng/ml 31222
Mouse major urinary protein 1 0.62-40 ng/ml 32150
Human plasminogen activator inhibitor type-1 0.031-2 ng/ml 31070
Human rentinol binding protein 4 3.12-200 ng/ml 31060
Featured ImmunoMetabolism Related Products
6ImmunoDiagnostics Limited
Website: www.immunodiagnostics.com.hk ; E-mail: [email protected]; Tel: (+852) 3502 2780; Fax: (+852) 3502 2781
All products are RUO
Distributed in the US by:www.diapharma.comE-mail: [email protected]: (800) 526-5224Technical: (800) 447-3846
www.immunodiagnostics.com.hk
A
Accurate
R
Rapid
E
Effective
ImmunoDiagnostics
Contact Us
Website: www.immunodiagnostics.com.hk
E-mail: [email protected]
Tel: (+852) 3502 2780; 5309 1323; 5605 3221
Fax: (+852) 3502 2781
ML-00-00060 Rev 2017