The Continuous Update Project: Introduction to the Project22 November 2015Martin WisemanWorld Cancer Research Fund International & University of Southampton
Who we are What we doFund research on the relationship of nutrition,
physical activity and body weight to cancer risk
Interpret the accumulated scientific literature to derive Recommendations for Cancer Prevention
Educate people through our national Health Information programmes
Advocate effective policies to help people and populations to reduce their chances of developing cancer
AICR WCRF UK WCRF Netherlands WCRF HKWCRF International
1. New method2. Systematic reviews3. Review of evidence separate from
judgement 4. Panel of international experts5. Predetermined criteria for judgements
EpidemiologyMechanisms
6. Flexibility7. Continuous update of evidence
WCRF/AICR EXPERT REPORT The most authoritative
NUTRITION AND CANCERS
• OBESITY– BREAST (PM), COLORECTUM, ENDOMETRIUM, OESOPHAGUS, PANCREAS,
GALLBLADDER, KIDNEY, LIVER, OVARY, ADVANCED PROSTATE
• PHYSICAL ACTIVITY– COLON, BREAST, ENDOMETRIUM
• MEAT – RED AND PROCESSED– COLORECTAL
• ALCOHOL – MPL, BREAST, COLORECTUM, LIVER
• FRUIT AND VEGETABLES– MPL, OESOPHAGUS, STOMACH, COLORECTAL (DF), LUNG
• BREASTFEEDING– BREAST (MOTHER), OBESITY (CHILD)
The Panel emphasises the importance of not smoking and of avoiding exposure to tobacco smoke
The Continuous Update Project. Aims
Ensure everyone has accessBased on the most up to date scientific evidence
WCRF/AICR Recommendations for Cancer Prevention:
• Keep evidence, conclusions and recommendations updated into the future• Working with team at ICL• Same principles: - Systematically review evidence- Meta analysis - Panel of experts
- draw conclusions - make recommendations
Continuous Update Project (CUP)
What is the Continuous Update Project?
Continuous update epidemiologic evidence (SLR- Imperial College London)
Up-to-date database
Mechanistic evidence (University of Bristol)
Evaluation of evidence (Independent panel of experts)
Recommendations
Education, policy and research priorities
The Continuous Update Process
Continuous update epidemiologic evidence (SLR- Imperial College London)
CUP Search Literature Review PROTOCOL(SLR- Imperial College London)
Research topic :The associations between food, nutrition and physical activity and Cancer risk Mortality and second cancers in breast cancer survivors.
Main objective :Summarize the evidence from prospective studies and randomised controlled trials (case-control studies if requested by the Panel).
Search strategy:Medline, Central, ClinialTrials.govHand search of references (reviews, meta-analysis, recent relevant papers)
http://www.wcrf.org/int/research-we-fund/continuous-update-project-cup/cancer-survivors-protocol-committee
One central database for cancer prevention research
Team
Database
CUP Expert PanelWCRF Secretariat
Statistical methods
Dose-response meta-analysis using generalized least-squares for trend estimation (command GLST in Stata)
Statistical methods
Publication bias Exploratory analyses
Statistical methods
Stratified analyses, sensitivity analyses
Until 2016 - Rolling programme of updates- Cancer by cancer
2016-2017 – Panel review evidence for all cancers
2017 – Statement to be published on evidenceFrom 2017 – continue to update and review
evidence
Plan of work
Year Publications2010 Breast2011 Colorectum2012 Pancreas2013 Endometrium2014 Ovary, prostate and breast cancer
survivors2015 Liver, kidney, gallbladder, bladder 2015-2016 Stomach, oesophagus, lung
2016-2017 Breast, colorectum
2017 Major report – Recommendations
Timeline
CUP database
CUP report downloads
Total downloads: 4273 vs. 806
Journal articles
Includes articles published by ICL (13), WCRF (1), UEA (1) + breast cancer survivors
The Continuous Update ProjectExpert Panel
www.wcrf.org/int/research-we-fund/continuous-update-project-cup