Download ppt - C D D Mind The Health Gap 2010 Talk.Ppt [ Autosaved]

Archive, Mine, Collaborate© 2009 Collaborative Drug Discovery, Inc.

• CDD Strong Community-Based Mission & Values• Neglected disease and commercial disease are both core components

• Collaborative culture – share successes and failures, as much as possible

• Tap leading community expertise with industry focused process

• Do Groundbreaking Work• Revolutionary approaches to solving critical health problems

• Imagine what would be possible in an ideal world, practically implement

• Discover drugs while changing the nature of the game

Copyright © 2010 All Rights Reserved Collaborative Drug Discovery


CDD aids Collaborations

ResultNew leads reveal known drugs that reverse chloroquine resistance


CDD Successfully Builds Collaborative Drug Discovery Communities

• DDT, 2009 (14: 261-270): • $2. 9M Tuberculosis B&MGF Project• >6 Years CDD SaaS in the Cloud • Thousands of scientists engaged:

Archive, Mine, Collaborate© 2009 Collaborative Drug Discovery, Inc.© 2009 Collaborative Drug Discovery, Inc.


Yes We Can!


• What are the challenges and opportunities for the field?• How are your priorities changing?• What are the emerging bottlenecks?• What if?

– Any technology, any collaborators, if you had a magic wand…

Register for GlaxoSmithKline on CDD Public



Networks Selectively Collaborating “Public-Private Partnerships”

# of [compds][targets][indications][experts] = (xyz)(pdq)(abc)(lmn)


CDD Database for Your Private Data



Collaborate Mode 1 – Big Pharma with single login to multiple CROs/Biotech groups

Collaborator 1 Collaborator 2 Collaborator 4Collaborator 3

Consolidated CDD DB

Project A Project DPro

ject B

Company A

Project C



Collaborate Mode 2 – Peer-to-Peer: Any Data via Any Query Can Be Securely Shared

CDD DB group 1

CDD DB group 2

CDD DB group 3

CDD DB group 4



• What are the challenges and opportunities for the field?• How are your priorities changing?• What are the emerging bottlenecks?• What if?

– Any technology, any collaborators, if you had a magic wand…

Questions for our Field



Where CDD Adds Value – Moving top Drug Leads Forward

CDD moves top leads forward

Value Academics + CDD

$0.1M

$1M

$10M

$5M

$0.3M

Enzymatic Assays

Cell BasedFunctional

Assays

Animal Efficacy

Tox/PK

Academic Early Drug

Leads

-1 yr-2 yr 2 yr

Med Chem

Lead Optimization

1 yr

CDD better than money alone

Billion $Examples:

Taxol


1. Spend only 20% on descriptors and algorithms2. Selectively share your models with collaborators and control access3. Have someone else host the models / predictions

What if you could…


Inside company

Collaborators

Current investments>$1M/yr

>$10-100’s M/yr


Yes we can…predictions now can be shared without revealing structures!


The future: Alerts in CDD


CDD Platform

• Modules:

• CDD Vault – Secure place for private data – private by default

• CDD Collaborate – Selectively share subsets of data

• Datasets:

• CDD Public – expanding public data sets

• published compounds

• data from community members

• vendor libraries

• Unique to CDD – simultaneously query your private data, collaborators’ data, & public data



Securely Zoom in-and-out of Private, Collaborative, and/or Public Vaults (Data)


Back Pocket

© 2010 Collaborative Drug Discovery, Inc.

Telescopic View of Multiple Vaults & Data Sets


Simultaneously Search All Vaults & Data Sets:Gets You “Outside the Box”


New Types of Offerings for a Rapidly Changing Industry

• CDD Community: tap into global R&D via “crowd-sourcing”• CDD Alliance: better management of your collaborations• CDD Customize: fast, good, and cost-effective = agile

Use CDD Vault™, Collaborate™, Public™ for Global R&D Community


Acknowledgements


• Industry: Eli Lilly & Co., GlaxoSmithKline, Pfizer

• Foundations: Bill & Melinda Gates Foundation, Myelin Repair Foundation

• Initial TB pilot laboratories

• Academics: CDD Researcher Community

• 1000s of CDD collaborators from academia, foundations and industry

• CDD: …including ChemAxon Tools under the hood

• Sean Ekins, PhD, DSc (Collaborations Director – Philadelphia)

• Pfizer, Lilly, Concurrent Pharmaceuticals, GeneGo

• Moses Hohman, PhD (VP Software Development – Chicago)

• Northwestern Assoc. Director of Bioinformatics, Thoughtworks, Inc., U of Chicago (PhD), Harvard (magna cum laude, Physics)

• Sylvia Ernst, PhD (Senior Director Community Growth – Oregon)

• Accelrys-Scitegic, MDL

• Andrea Barry (Senior Director Business Dev – N. Carolina)

• Accelrys-Scitegic, MDL

• Kellan Gregory (Head Community Interests Group – California)

• Anna Spektor (Community Advocate, ex-IDBS)


• Start with Strong Mission & Values• Neglected disease and commercial disease are both core components

• Collaborative culture – share successes and failures, as much as possible

• Tap leading community expertise with industry focused process

• Do Groundbreaking Work• Revolutionary approaches to solving critical health problems

• Imagine what would be possible in an ideal world, practically implement

• Discover drugs while changing the nature of the game

• What if…you had a magic wand?


Answers for Our Field


CDD Collaborative Drug Discovery, Inc.

Burlingame, CAwww.collaborativedrug.com

Barry A. Bunin, PhDCEO & President

[email protected]

Archive, Mine, Collaborate®


CDD3 Data Mapper:Intuitive Templates and Previews Simplify Archival



CDD Projects – More Advanced Collaborate


Collaborative Dashboard for SecureTo-the-Minute Global R&D Tracking



CDD Case Study: Create a Globally Connected TB Researcher Community

• TB Literature and Patent SAR: > 125,000 public TB Bioassay data points for all researchers to use• TB Literature and Patent SAR: > 125,000 public TB Bioassay data points for all researchers to use

• 20 pilot user groups oversubscribed• 5 consortium actively utilizing CDD software for TB research• Implemented scalable policy for worldwide use (free software, paid services)…beyond the Bill & Melinda Gates Foundation project

• 20 pilot user groups oversubscribed• 5 consortium actively utilizing CDD software for TB research• Implemented scalable policy for worldwide use (free software, paid services)…beyond the Bill & Melinda Gates Foundation project


CDD database system

• Web based (log in securely into to your database from any computer).

• We host the server for you (SaaS)• Highly secure, all traffic encrypted, server in a secure

professionally hosted environment.

Secure and Low TCO (Total Cost of Ownership)



CDD database system: Security overview

• CDD encrypts all traffic between a user's web browser and our servers once the user has logged in.

• CDD does thorough automated testing of our application code, including security tests to make sure one group cannot access another group's private data.

• CDD uses two levels of firewalling ("defense in depth"), hardware and software, for each sensitive server in our server environment.

• CDD encrypts all database and customer file backups using public key cryptography, and the private keys are backed up securely.

• CDD stores user passwords in our database using strong, one-way encryption hashes. • CDD stays current with all security updates to our system software, firmware and operating

systems. • CDD uses Linux systems in production. • A number of application security enhancements around password security are being made

mandatory. • Access to production servers and superuser accounts is limited and audited within CDD.



Fundamentally Faster Rate of Innovation



CDD Search Results View



Super Simple Scatter Plots


Heat Maps, Controls, & Plate Statistics
