Neurotransmitter Receptors in the AmygdalaAmygdala

Basomedial Nucleus(Accessory Basal)

Cortical Nucleus

Basolateral Nucleus

Medial Nucleus

Central Nucleus

Lateral Nucleus

Coronal Brain Section

Amygdala

The Amygdala (Greek for “almond-shaped”) is a nuclear complex found in the medial temporal lobe. It was initially described in the fi rst-half of

the 19th century by the German physician Karl Burdach, who also co-coined the term “morphology”. The amygdala suff ers from both a lack of

consensus regarding its anatomical structure, and the relationships of its structures (or nuclei) to adjacent brain areas. Here, we consider the

central and medial nuclei to be a phylogenetically “old” complex that has an association with olfaction, and the lateral and basolateral nuclei to

be phylogenetically “new” with connections to the cerebral cortex. In general, glutamatergic inputs target the lateral nucleus. The terminals can

end on amygdaloid glutamatergic projection neurons that further project to the basolateral and centromedial nuclei. These nuclei may

contribute additional intra-amygdaloid connections, or impact neurons in the central nucleus which typically transmit inhibitory signals to

neurons in autonomic centers. Alternatively, glutamatergic inputs to the lateral nucleus may end on lateral nucleus GABA neurons. This activates

GABA neurons, which subsequently inhibit lateral nucleus projection neurons, creating a feed forward inhibition pathway. In addition,

glutamatergic lateral nucleus neurons can act on adjacent GABAergic neurons, generating an inhibitory signal in a feedback inhibition pathway.

This schematic depicts potential neuronal processes, their interactions, and associated neurotransmitter receptors. R&D Systems currently off ers

antibodies to all labeled molecules.

PM_09.11_amygdala_OCT

NOTE: This poster conveys a general overview and should be considered neither comprehensive nor defi nitive. The details of the process are understood to be subject to interpretation. © R&D Systems, Inc. 2011 R&D Systems, Inc., 1-800-343-7475, www.RnDSystems.com/Neuroscience

PYRAMIDAL NEURON

(CaMK+)

ACCESSORY OLFACTORY BULB

GLUTAMATERGIC AFFERENT

GABAergic NEURON

(Estrogen Receptor +,

Parvalbumin+)

mGluR8

mGluR7

mGluR2

Glutamate Vesicles

mGluR2/R3

PERIAMYGDALOID CORTEX

GAD67+

GAD65+

PYRAMIDAL NEURON(CaMK+)

GLUTAMATERGIC AFFERENTGABAergic NEURON

(Parvalbumin+)

GABAergic NEURON(Cholecystokinin+)

(Vasointestinal Peptide+)

GABAergic NEURON(Cholecystokinin+)

mGluR3

GluR2 GluR3

mGluR5

mGluR2

mGluR7 GluR2GluR3

GluR1

mGluR1a

GABA Vesicles

GABA Vesicles

GABA Vesicles

GABAAR ( 3) GABA

AR ( 3)

Glutamate Vesicles

GABABR1

GABABR2

CannabinoidReceptor 1Kv3.1

K+ Channel

NPY R1

Kv2.2K+ Channel

Leptin R (Ob R)

mGluR3Glutamate Vesicles

BASOLATERAL NUCLEUS

GLUTAMATERGIC AFFERENT

NMDAR(NR2C)

GABAAR

( 1, 2+3)

GABAAR

( 1, 2+3)

GABA Vesicles

GABA Vesicles

PYRAMIDAL NEURON(CaMK+)

GABAergic NEURON(Parvalbumin+)

GABAergic NEURON

DOPAMINERGIC AFFERENTfrom VENTRAL TEGMENTAL AREA

NMDAR (NR1,NR2B)

NMDAR (NR2C)

GABABR1

TRPV1

Cannabinoid Receptor 1

GABABR2

Dopamine Transporter

Glutamate Vesicles

Glutamate Vesicles

Dopamine Vesicles

GLUTAMATERGIC AFFERENT

mGluR5

mGluR1a

NMDAR (NR1,NR2A)

GluR (2,3)

NMDAR (NR1,NR2A)

LATERAL NUCLEUS

PYRAMIDAL NEURON(CaMK+)

GABAergic PROJECTION NEURON

(Vasointestinal Peptide+,Somatostatin+)

NMDAR (NR1,NR2A)

GABAAR

( 2, 1, 2)

Corticotropin-releasing Hormone Receptor 1

Corticotropin-releasing Hormone Receptor 1 Glycine R ( 1, )

Somatostatin Receptor 2

GABAAR

( 2, 3, 1)

GLUTAMATERGIC AFFERENT

INTERCALATED CELL MASSES AFFERENT

BED NUCLEUS OF THESTRIA TERMINALS AFFERENT

TrkB

mGluR5

GAD67+

mGluR1a

GABA Vesicles

GABA Vesicles

GABAAR ( 2, 1)

Glutamate Vesicles

Vasointestinal Peptide Receptor 2

CENTRAL NUCLEUS

GABAergic NEURON(Neuropeptide Y+)

Glucagon-like Peptide Receptor 1

MEDIAL NUCLEUS

Nogo-C

GABAB R1 BSRP-A

Vanilloid R1

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research. In addition to high performance antibodies, we off er the most

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