Supplemental Figure S1 MgloSLP :UmSLP :PgraSLP :MlarpSLP :RgluSLP :BdenSLP :TgSLP :CparSLP :LbSLP :CneoSLP :SpSLP :Q1D163_MYX :F8CJ73_MYX :Q08Y53_STI :H8MYK0_COR :Q028W8_SOL :B8KKW3_9GA :A4ABU5_9GA :A0Z563_9GA :AlSLPa :AtSLP1 :CarSLPa :BrSLPb :ThalSLPb :AcSLPa :AcSLPb :CpaSLPa :CcSLPb :CsSLP :CsSLPb :GrSLPb :MdpSLPd :PperSLPb :MdpSLPe :VvSLPb :MeSLPb :PtSLPa :PtSLPb :PtSLPc :PtSLPd :RcSLPb :MgSLPa :MgSLPb :GmSLPb :GmSLPc :PvulSLPb :MtSLPb :EgSLPa :EgSLPb :CsatSLPa :CsatSLPb :LuSLPc :BdSLPa :PvSLPa :PvSLPb :PvSLPc :SiSLPa :SbSLPa :ZmSLPb :OsSLPa :PpaSLPc :PpaSLPa :SmSLPa :CrSLPa :VcSLPb :CvSLPb :CocSLPa :MpSLPc :MpSLPd :OlSLPa :OrcSLPa :OtSLPc :MpSLPb :MpSLPf :OlSLPc :OtSLPb :OrcSLPb :A9EUH1_SOR :D0LQ64_HAL :A6FXL1_9DE :A6G215_9DE :AlSLPb :AtSLP2 :CarSLPb :ThalSLPa :BrSLPa :CpaSLPc :CcSLPa :CsSLPa :MeSLPa :RcSLPa :PtSLPe :GrSLPa :CsatSLPc :GmSLPa :GmSLPd :PvulSLPa :MtSLPa :MdpSLPa :MdpSLPb :MdpSLPc :PperSLPa :LuSLPa :LuSLPb :CpaSLPb :VvSLPa :AcSLPc :MgSLPc :BdSLPb :OsSLPb :PvSLPd :SiSLPb :SbSLPb :ZmSLPa :PpaSLPb :SmSLPb :MpSLPa :MpSLPe :OlSLPb :OtSLPd :OrcSLPc :CocSLPb :CvSLPa :CrSLPb :VcSLPa :ZmSLPd :ZmSLPf :ZmSLPg :CmSLP :EhSLPa :GtSLPe :GtSLPd :FcSLP :TpSLP :EsSLPa :EsSLPb :GtSLPb :GtSLPc :GtSLPa :CpSLP :AaSLPa :TcSLPa :LmSLPa :TbSLPa :TcSLPc :CrSLPc :VcSLPc :MpSLPg :MpSLPh :OlSLPd :OrcSLPd :OtSLPa :PmSLPa :PmSLPb :ZmSLPc :ZmSLPe :EhSLPb :LmSLPc :TbSLPb :TcSLPb :LmSLPb :F4KVD8_HAL :G8T712_NIA :F9YU86_CAP :B8CJM1_SHE :A8FSQ7_SHE :A0KU52_SHE :A6WR58_SHE :A6LG58_PAR :A6L339_BAC :PbSLPa :PySLPb :PchaSLPb :PvxSLPa :PbSLPb :PySLPa :PchaSLPa :PvxSLPb :C7JGL0_ACE :G2I4P6_GLU :A9HIJ4_GLU :Q5FPF8_GLU :F0IZ02_ACI :A5FYZ4_ACI :C8W9T6_ATO :E6X796_CEL :A4APQ2_MAR :A4CIK5_ROB :G8XAS9_FLA :C7PBV5_CHI :B7KAY7_CYA :B7K033_CYA :G6H040_9CH :G6GVE8_9CH :A3IN61_9CH :I4GUD1_MIC :B8HLS9_CYA :B1XJX5_SYN :B1WW02_CYA :E0UG92_CYA :Q3M7X2_ANA :B0JIT7_MIC :F2N9L1_COR :F7UVF4_EEG :C7N2D2_SLA :C7N0S7_SLA :PcapSLP :PiSLP :PsSLP :PrSLP :PutSLP :TtSLP :

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260HRRIVALGDIHGDYEHATSILRAAGILHSWAGGSTIFVSTGDTVDRGDDTIRLYRLPQDLREQSRRVGGNVINVLGNHEMMNA---------------MMD---WRYVTPGDMASFGGPRRQAMSLHGWLGMEWMQNVTMNVQRASFVHGGITPAFAIGVDAMNKDAHSLLTKALWLS----D-GPFWYRGYALD-ACATANRAIDALG-----VSSLIMGHTPHSG-IHARCHGQIFIIDTGMSRAGRLSALEIDSYAYSAVYVPEGSRRTVAVADLHGDLDHALNVLSMASIVSTWIGGHDTLVSTGDIVDRGDDTIALYRLPVSLRQQARLAGGEVKNCLGNHEVMNA---------------IGD---WRYVTKADVESFGGVRRHAMSDQGWIGQEWLHNVTHTIPRVSFVHGGITPQYALGIDFINTVGHSLLLKGLWSE----H-GPLWYRGYATD-ACANAEKATKSLA-----VNQLVMGHTPHDG-FVTRCNNTILLIDTGISRAGQQSALIIDFDLLTALYKARPSSRIVAVGDLHGDLDHAVRVLRMAGVVDQWIGGPSILVQTGDIVDRGKATILLYKWMDALRTEAQAAGGAVVSLLGNHEYMNA---------------LGD---WRYVTKEDIETFGSARRKVMSTQGWIGKTWEASVTARIAGTVFVHGGITPEYALGISEINRIGHSLLHRALYAE----H-GPLWERSYALEDICRQIEIATQRLH-----VRRMVMGHTPQKG-ISSRCGGKILLIDTGISSAGPLTALEINYSLIQELADKKKKQRVVAIGDLHGDLPHAVRVLRLAELIDKWIGKKTVLVQTGDIVDRGRDTIVLYQLMDRLRNEAKAAGGAVVSLLGNHEYMNA---------------LGD---WRYVTEEDIETFGGKRRKLMSSEGWIGESWLKNTTARVSAIAFVHGGITPEYAIGISEINRIGQSFLNRSLYSS----H-GPLWERSYALEEICDQIEKTINLLN-----VRRLVMGHTPQKG-ILGRCQGKILLIDTGISSAGALSALEIQYTLVHGLQEGKLRQRIVAMGDIHGDLPAATKILRRAEVVDQWIGGDTILVQTGDIVDRGPDTIALYRFFQSLRPQAERAGGAVVSLLGNHEMMNC---------------LGD---YRYVTKEDIASFGGERREAFLH-GWIGQEFRASVTARVSAISFVHGGITPEYSSPITDINRIGHSILESLLWSE----R-GPMWNRDWALE-ICERVEKALEVLN-----VRRMVMGHTPQEG-ILSRCDGKILLIDTGISRAGAHSSLSLTYTLVEALYTAGRPSRIIAVGDLHGDLAQALKTLKMARIMNEWIAGSSIFVQTGDVVDRGPDTIKLYKMLYDLKVQAEEHGGQVIQLLGNHEVMNM---------------AED---LRYVTEGDYSSFGGHRRKAFDKDGWPG-NYLRNITTWVNGTVFFHGGAHPQWALGIDGMNLRAHNGLIGRSFGG----S-GPLWFRGYAED-ICKQLDKALADMN-----AVRMVVGHTPQDGSVLRRCNGKLYVIDVGISRVGNSAALEI-------------GSRILAVGDLHGDIGNTMLLLYGAGVVDNWIAGDTLLIQTGDVVDRGPDGKRIYDYFASLSAQATEQGGKIIQLLGNHDVMNI---------------CGD---FRYAHPSETIEFGGARRRQFMDGGHYG-NMLRPLSIKANGVIFSHAGIPSDFALGLSKLTQQLREELANDCAGS----Q-GPLWTRVYSMG-ICEELDKTLGILD-----SEKMVIGHTVQSGNIEVYCGGRLLLIDTGVSRYDSPRMLEIRDGS---------KGRVLVIGDIHGDLKSLITSLFLSGVINDWIAKNTLLIQLGDVVDRGSHALQIYKLFNKLKSQAPSLGSKFVGLLGNHEVMNL---------------CGQ---LHYVTDEDFQTYGGRRTFEWSKEGFVG-KYLRKLAIRVNDSLYVHAGLLPKYALGLDKLDKLSNDLLEGDFFVE----D-GPLWTRDISLG-ACKLVDETLQILG-----LSRMVVGHTIQDNRINIKCDNKLILADTGFSEAGKPCMLEILYHN---------TRHIVAVGDLHGDLPNARKVLQFSGITDDWTGDVDFFVQTGDIIDRGDDTIPLFFWMDKLRSQAAAVGGTVLSHLGNHEWMNV---------------IGD---WRYVYPTEIKTFGSVRQQMLTT-GRIGRSWAATTASRLSAISFVHGGLSPTYTLTPSRINQISDSLLAKLQYDG----N-GPLWYRGWATD-VCADVDRVLAKTG-----TRRMIMGHTPDKN-IKARCGGKIIIIDTGISHAGALSALSLYYSLVSAIYQHRRRQRLVAVGDLHGDIDNAKKTLQMARIIDKWVASTDILVQTGDIVDRGAYADDIYRLMQSLRGQAASQGGKVVSILGNHEVMNA---------------IGD---WRYVTKGDIARFGGTRQHALSAEGWLGQEWLASTTALVPTFSFTHGSLRPSYALTPAAINDLGHSLLTKALYAE----G-GPLWWRGLAER-VCEWAKNLKQKIG-----ARRIIGGHTPNEK-IVARCNASVIIIDTGISSAGVLSALEIVYTLVHAIYEHSRPTVVYAIGDIHGDFPNALDVLSAAGVVSEWTAGNATLVQTGDVVDRGPDTRKLFRWFNDLHKQAEKHGGRVVRLLGNHEFMNA---------------KGD---WRYVHPGDKASYPEPRIIDWGHSGEIGNLLLSNVTYKDNTSHFMHAGLSPEWAYREETVNELGKELLSHFMWAI----E-GPMWYRGLAQL-ACEVALNVTKTLN-----VNRLVMGHTPQHG-IVSRCEGRILLIDTGLCSAGERAVLRISQNDVEAVYRGKIVERVVAVGDVHGDVDALKEVLRLAGLIDRWIGGKTHLVQTGDVPDRGDQTRAAFDLLMRLEQEALAAGGRVHALLGNHEAMNM---------------LGD---LRYVNPGEMASFADQHRVAYSLQGRYG-QWLRAAVVRINDTLFVHGGVAPGVPGNLAELNRWVRQDFFPDHRDA----Q-GPLWFRGYALG-AEPALDAVLKRYG-----ARRMVMGHTTNDGKVKVRFNGKALLIDTGLSTGRNLAALELRGGKVNALYREGPVERVVAVGDVHGDVDALKEVLRLAGIIDRWIGGKTHLVQTGDIPDRGDQTRAAFDLLMRLEQEALAAGGRVHALLGNHEAMNM---------------LGD---LRYVSPGEMASFADQHRVAYSLQGRYG-QWLRAAVVRINDTLFVHGGVAPGVPTDLSALNRWVRQDFFPGQRNP----Q-GPLWFRGYALG-AGPALDAVLQRYG-----ARRMVMGHTTNDGKVKVRFNGKALLIDTGLSTGRNLAALELRGGKVNALYREGPVERVVAVGDVHGDVEALKEVLRLAGLIDQWTGGKTHLVQTGDIADRGARTREAFELMMRLEREALAAGGRVHLLLGNHEVMNM---------------RGD---LRYVTPEELASFAGLHRAAYGLEGRYG-RWLRPAVVRIDGTLFLHGGLHPEVPKTLGALNRWTRQDLFPDATDA----K-GPLWFRGYAQE-WSQGLDAVLERFG-----ARRMVMGHTPTDGRIGVRFGGRAVLIDTGLSTYRHLAALEIRGDRLTALYPDGRVERIVAVADVHGDVDALKEVLRLAGLIDHWIGGKAHLVQTGDLPDRGDHTRDAFELLMRLETEARKAGGRVHPLLGNHELMNM---------------RGD---LRYVTPGEFASFADQHAAAYAADGRYG-KWLRPAVIRINDTLFLHGGLAPTVPTTLEEVNRWVWQDLTPGQVDP----Q-GPVWFRGYAID-WDAGLTQVLERFS-----ARRMVMGHTPSDGRLSIRFGGRVIVIDTGLSTHRHLAALELRGDRLTALYPEGRVPRVVAVGDVHGDYNGFVEVLRSAGVIDHWAGGKTHLVQTGDVPDRGPDTRKAMDLLMQLEKEADKAGGHVHALVGNHEAMNV---------------YAD---LRYTTPAEFAAFVDNQRIAFSSEGKYG-KWIRNALVKINDTIYLHGGISPRYAMTVKQINEAVAAELNDLPMGT----D-SPLWYRGIALE-IAAHVDLVLKTND-----AQRIVISHTVTGA-IIERFGGKVVMIDTGMTAVGHRACLLLEGDKVYAIHRGEKIDRVVAIADLHGDYQSYITVLEQAGLVNRWTGGTTHLVQLGDVPDRGPDTARIIEHLMKLETQAKKAGGKVHALIGNHEVMNM---------------TGD---LRYVHPGEYEALKSRHRQHWLPNGEFG-AWVANTVVRINRSLFVHAGISPDYLRSIGDINDAVRAELAKPNVDE----R-GPLWYRGLALGDVAVEVDALLKYFD-----VDRIVVGHTPGGT-VVPRYDARVIAADSGLAQHGHLASLLIEGGKVYTLQRGQQVERVVAVADLHGDYDNYITVLRQAGVIDRWDAGKTHLVQLGDVPDRGPDSDKIIRHLMKLEEQAEKAGGKVHPLIGNHEVMNI---------------TGD---LRYVHPGEYEALTSRHRQHWHPEGQFG-AWVANTVIRINRSLFVHGGIGPDYLASMEDINDTVREELRAPDEDE----E-GPLWYRGLIMGEIAAHVDALMERFD-----VDRIVMGHTPGGT-VVPRYHGRVLAADSGIAEYGNLASVLIENGQAFTLQSGERSETVIAIGDVHGDHEQFVKLLQATKLIDRWTGGETHLVQLGDLPDRGPDTRKTMDLLLELQTSSIEQGGAVTTLIGNHDMMNV---------------MND---LRYVDPGEYKAFRSRHRLAWAPTGTYG-EWVLPTVAVVGDSLFVHGGISPDYIMSIEDINTAVHSAMGEGYYDP----L-GPLWFRGWSQDLNTMALNSILNKYG-----VARMVVAHTPVPV-VVPRYDGKIIMVDVGLSQHHGFSALKIENGQTMAMVGDRWARRIVAVGDLHGDLGKARDALQMAGVLSQWIGQDSVLVQVGDILDRGDDEIAILSLLRSLDGQAKANGGAVFQVNGNHETMNV---------------EGD---FRYVDARAFDECTDFRSILFRPGGRLACE-LAGVILRVNNWIFCHGGLLPHHVYGVERINREVSTWM-RSPRGY----D-SVVWSRLYSRETVNKILHDTLEAVG-----AKAMVVGHTPQSG-VNCEYGCSIWRVDVGMSSGSRPEVLEIRGDKARVIRSNRDARRIVAVGDLHGDLGKARDALQLAGVLSQWVGQDTVLVQVGDILDRGDDEIAILSLLRSLDDQAKANGGAVFQVNGNHETMNV---------------EGD---FRYVDARAFDECTDFRSVLLRPGGRLACE-LSGVILRVNNWLFCHGGLLPHHVYGIERINREVSTWM-RSPRGY----D-SVVWSRLYSRETVNKILHDTLEAVG-----AKAMVVGHTPQSG-VNCEYGCGIWRVDVGMSSGSRPEVLEIRGDKARVIRSNRDARRIIAVGDLHGDLSKARDALQLGGVLSQWIGQDT----VGDILDRGDDEIAILSLLRSLDVQAKANGGAVFQVNGNHETMNV---------------EGD---FRYVDARAFDECTDFRSVLFRPGGRLACE-LAGVVLRINNWVFCHGGLLPHHVYGVERINREVSTWM-RSARGY----D-SVVWSRLYSRETVSKILRDTLDAVG-----AKAMVVGHTPQSG-VNCEYGCGIWRVDVGMSSGSRPEVLEIIGDKARVIRSNRDSRRIIAVGDLHGDLSKARDALQIAGVLSQWVGEDTVVVQVGDILDRGEDEIAILSLLRLLDEQAKANGGAVFQVNGNHETMNV---------------EGD---FRYVDTRAFDECIDFRSVLFRPGGRLACE-LSGVVLRVNNWVFCHGGLLPHHVYGVERINREVSTWM-KSSRGQVESSK-TVKSSSAWIECVVGKILRDSLEAVG-----AKAMVVGHTPQSG-VNCEYGCGIWRVDVGMSSGSRPEVLEIRGDKARVIRSNQD----LAV-------------------------SSQVLVQVGDILDRGDDEIAILSLLRLLDEQAKANGGAVFQVNGNHETMNV---------------EGD---FRYVDARAFDECTDFRSVLFRPGGRLACE-LAGVILRVNDWVFCHGGLLPHHVYGVERINREVATWM-RSYRGY----D-SVVWSRLYSRETVSKILRDTLEAVG-----AKAMVVGHTPQSG-VNCEYGCSIWRVDVGMSSGSRPEVLEIRGDKARVIRSNQDGRRIVAVGDLHGDLAQTRCALELAGVLSLWTGEETVLIQLGDILDRGEDEIAILSLLRSLSNQAKSKGGAVFQLNGNHETMNV---------------EGD---FRYVDPGAFNECGDFRSALLRPGGPLACE-LAAVVLKVDDWVFCHGGLLPRHVYGIERMNREVSHWM-KGLRGY----D-SVVWNRLYSRDLIQAVLEDTLDAMG-----AKAMVVGHTPQAG-INSKYSSSIWRIDVGMSSGSRPEVLEIIDNEARVIRSNRQGRRIVAVGDLHGDLAQTRCALELAGVLSLWTGEETVLIQLGDILDRGEDEIAILSLLRSLSNQAKSKGGAVFQLNGNHETMNV---------------EGD---FRYVDPGAFNECGDFRSALLRPGGPLACE-LAAVVLKVDDWVFCHGGLLPRHVYGIERMNREVSHWM-KGLRGY----D-SVVWNRLYSRDLIQAVLEDTLDAMG-----AKAMVVGHTPQAG-INSKYSSSIWRIDVGMSSGSRPEVLEIIDNEARVIRSNRQGRRIIAVGDLHGDLDQARFALQMAGVLSLWTGGETVLVQLGDILDRGEDEIAILSLLRLLDVQAKDVGGAVFQVNGNHETMNV---------------EGD---FRYVEAGAFDECGAFRTALFRPGGPLACE-LASVVLRVNDWVFCHGGLLPNHVYGIERMNKEVSSWM-RGFRGY----D-SVVWNRLYSRDNINAILQDTLQAVG-----AKAMVVGHTPQEG-VNCKYNCSIWRVDVGMSSGSRPEVLEISDDKARVIRSKREGRRIVAVGDLHGDLDQARCALAMAGVLSLWTGGESVLIQLGDVLDRGEDELAILSLLRSLDMQAKAEGGAVFQVNGNHETMNV---------------EGD---FRYVDSGGFDECSDFRSVLFRPGGPMACE-LAGVVLKVNDWVFCHGGLLPHHVYGLERMNNEVSLWM-KGLRGY----D-SVVWNRLYSRDIINAVLQDTLRAVG-----AKAMVVGHTPQAG-ANCEYNCSIWRIDVGMSSGSRPEVLEITDNKARVISSKRDGRRIVAVGDLHGDLDQARCALEMAGVLSLWTGGESVLIQLGDVLDRGEDELAILSLLRSLDMQAKAEGGAVFQVNGNHETMNV---------------EGD---FRYVDSGGFDECSDFRSVLFRPGGPMACE-LAGVVLKVNDWVFCHGGLLPHHVYGLERMNNEVSLWM-KGLRGY----D-SVVWNRLYSRDIINAVLQDTLRAVG-----AKAMVVGHTPQAG-ANCEYNCSIWRIDVGMSSGSRPEVLEITDNKARVISGKRDGRRIVAVGDLHGDLDQARCALEMAGVLSLWTGGESVLIQLGDVLDRGEDELAILSLLRSLDMQAKAEGGAVFQVNGNHETMNV---------------EGD---FRYVDSGGFDECSDFRSVLFRPGGPMACE-LAGVVLKVNDWVFCHGGLLPHHVYGLERMNNEVSLWM-KGLRGY----D-SVVWNRLYSRDIINAVLQDTLRAVG-----AKAMVVGHTPQAG-ANCEYNCSIWRIDVGMSSGSRPEVLEITDNKARVISGKRDGRRIVAVGDLHGDLDQARYALEMAGVLSLWTGEDAVLVQLGDVLDRGDDEIAILSLLRSLDIQAKAKGGAVFQVNGNHETMNV---------------EGD---FRYVESGAFDECADFRSVLFRPGGPLACE-LAAVALKVNDWIFCHGGLLPHHVYGIEKMNKEVSQWM-RGLKGY----D-SVVWNRLYSRNIINAILQETLQALG-----AKAMVVGHTPQSG-ANCEYNCSIWRIDVGMSSGSRPEVLEIRDDKARVIRSKRN----MSVGDLHGDLGQTRCALETAGVLSVWIGGETVLIQLGDILDRGEDEIAILSLLRSLDMQAKAEGGAVFQVNGNHETINV---------------EGD---FRYVDTGGFDECLDFRSILLRPGGPLARE-LAAVVLKVNDWVFCHGGLVPQHVYGVERMNREVSDWM-RGLRGY----D-SVVWNRLYSRDTINYILQQTLQAVG-----AKGMVVGHTPQTG-ANCEYDCSIWRIDVGMSSGSRPEGLSSLNM----------GRRIVAVGDLHGDLDQTRCALEMAGVLSLWTGGETVLIQLGDILDRGEDEIAILSLLRSLDIQAKDEGGAVFQVNGNHETMNV---------------EGD---FRYVETGGFDECIDFRSILLRPGGPLACE-LAAVVLKVNDWVFCHGGLIPNHVYGVERMNREVSHWM-RGLRGY----D-SVVWNRLYSRDTIHSILEETLHAVG-----AKAMVVGHTPQTG-ANCKYNCSIWRIDVGMSSGSRPEVLEIKDNKARVIRSKKDYRSVLCVGDLHGDLGQTRCALETAGVLSVWIGGETVLIQLGDILDRGEDEIAILSLLRSLDMQAKAEGGAVFQVNGNHETINV---------------EGD---FRYVDTGGFDECLDFRSILLRPGGPLARE-LAAVVLKVNDWVFCHGGLVPQHVYGVERMNREVSDWM-RGLRGY----D-SVVWNRLYSRDTANKLHSSTDATSG-----NGGGAYSSTYGKL-VRCEYDCSIWRIDVGMSSGSRPEVLEIKDNKARVIRSKKDGRRIVAVGDLHGDLAQARCALEMAGVLSLWTGGDTVLVQLGDILDRGEDEIAILSLLRSLDIQAKASGGAVFQVNGNHETMNV---------------EGD---FRYVDSGAFDECTDFRSILLRPGGLLACE-LAAVVLKIDDWVFCHGGLLPHHVYGIERMNREVSHWM-RGLRGY----D-SVVWNRLYSRDVIYSLLEETLQAVG-----AKAMVVGHTPQVG-VNCKYDCSIWRIDVGMSSGSRPEVLEIRDNTARVIRSKRDGRRIVAVGDLHGDLDQARCALEMAGVLSLWIGGETVLIQLGDILDRGEDEIAILSLLRSLDIQAKAQGGAVFQINGNHETMNV---------------EGD---FRYVDSGAFDECTDFRSILLTPGGPLACE-LASVILKVNDWIFCHGGLLPQHVYGIERMNSKVSQWM-KGLKGY----D-SVVWNRLYSRDVILSILEETLQAIG-----AKAMVVGHTPQAG-VNCKYNCSVWCVDVGMSSGSRPEVI---------------GRRIVAVGDVHGDLDQARCALEIAGVLSLWTGGETVLIQLGDVLDRGEEEIAILSLLRSLDIQAKAQGGAVFQVNGNHETMNV---------------EGD---FRYVDSGAFDECSDFRSILLRPGGPLACE-LAAVVLKINDWVFCHGGLLPQHVYGVERMNYEVSHWM-RGLKGF----D-SVVWNRLYSRDMIQSVLEETLQLLG-----AKAMVVGHTPQTG-VNCKYNCSIWCIDVGMSSGSRPEVLEIVENKARVIRSKRDGRRIVAVGDVHGDLDQARCALEIAGVLSLWTGGETVLIQLGDVLDRGEEEIAILSLLRSLDIQAKAQGGAVFQVNGNHETMNV---------------EGD---FRYVDSGAFDECSDFRSILLRPGGPLACE-LAAVVLKINDWVFCHGGLLPQHVYGVERMNYEVSHWM-RGLKGF----D-SVVWNRLYSRDMIQSVLEETLQLLG-----AKAMVVGHTPQTG-VNCKYNCSIWCIDVGMSSGSRPEVLEIVENKARVIRSKRDGRRIVAVGDVHGDLDQARCALEIAGVLSLWTGGETVLIQLGDVLDRGEEEIAILSLLRSLDIQAKAQGGAVFQVNGNHETMNV---------------EGD---FRYVDSGAFDECSDFRSILLRPGGPLACE-LAAVVLKINDWVFCHGGLLPQHVYGVERMNYEVSHWM-RGLKGF----D-SVVWNRLYSRDMIQSVLEETLQLLG-----AKAMV-------------------------------------------------GRRIVAVGDVHGDLDQARCALEIAGVLSLWTGGETVLIQLGDVLDRGEEEIAILSLLRSLDIQAKAQGGAVFQVNGNHETMNV---------------EGD---FRYVDSGAFDECSDFRSILLRPGGPLACE-LAAVVLKINDWVFCHGGLLPQHVYGVERMNYEVSHWM-RGLKGF----D-SVVWNRLYSRDMIQSVLEETLQLLG-----AKAMVVGHTPQTG-VNCKYNCSIWCIDVGMSSGSRPEVI---------------GRRIVAVGDLHGDLDQARCALEMAGVLSLWIGGETVLVQLGDILDRGEDEIAILSLLRSLDIQAKAEGGAVFQVNGNHETMNV---------------EGD---FRYVDSGAFDECTDFRSVLLRPGGPLACE-LASVILRINDWIFCHGGLLPHHVYGIERINREVSQWM-KGLRGY----D-SVVWNRLYSRDMILSILEETLQSAG-----AKAMVVGHTPQAG-VNCKYNCSVWRIDVGMSSGSRPEVLEIQNDKAKVIRSRKDGRRIIAVGDLHGDLDKARYALQMAGILSLWIGGQTVLVQLGDILDRGEDEIAILSLLKSLNIQAKLNGGAVFQVNGNHETMNV---------------EGD---FRYVDSGGFDECADFRSVLLRPGGPLASE-LAAVVLKVNDWIFCHGGLLPHHVYGIERINREVSYWM-EGLRGY----D-SVVWSRLYSRDTIESILRETLQAVG-----AKAMVVGHTPQTG-VNCDFNCSIWRIDVGMSSGSRPEVLEIREGRARAIRSKRDGRRIIAVGDLHGDLDKARYALQMAGILSLWIGGQTVLVQLGDILDRGEDEIAILSLLKSLNIQAKLNGGAVFQVNGNHETMNV---------------EGD---FRYVDSGGFDECADFRSVLLRPGGPLASE-LAAVVLKVNDWIFCHGGLLPHHVYGIERINREVSYWM-EGLRGY----D-SVVWSRLYSRDTIESILRETLQAVG-----AKAMVVGHTPQTG-VNCDFNCSIWRIDVGMSSGSRPEVLEIREGRARAIRSKRDGRRILAVGDLHGDLKQARSALEMAGVLSLWTGGETVLVQLGDILDRGEDEIAILSLLRSLDKQAKAKGGAVFQVNGNHETMNV---------------EGD---FRYVDSGGFDECNDFRSILFRPGGLLARE-LAAVVLKVNDWVFCHGGLLPHHVYGLERMNKEVSEWM-RGQRGY----D-SVVWNRLYSRDTVCSILDETLQAVG-----AKAMVVGHTPQIG-VNCKYNCSIWRVDVGMSSGSRPEVLEIIDDKARVIRCKRDGRRILAVGDLHGDLKQARSALEMAGVLSLWTGGETVLVQLGDILDRGEDEIAILSMLRSLDRQAKEKGGAVFQVNGNHETMNV---------------EGD---YRYVESGGFDECNDFRSILFRPGGLLARE-LAAVVLKVNDWVFCHGGLLPHHVYGLERMNKEVSEWM-RGQRGY----D-SVVWNRLYSRDTVCSILDETMQAVG-----AKAMVVGHTPQIG-VNCKYNCSIWRVDVGMSSGSKPEVLEIIDDKARVIRCKRDGRRILAVGDLHGDLKQARSALEMAGVLSLWTGGETVLVQLGDILDRGEDEIAILSLLRSLDKQAKAKGGAVFQVNGNHETMNV---------------EGD---FRYVDSGGFDESNDFRSVLFRPGGLLARE-LAAVVLKVNDWVFCHGGLLPHHVYGLERMNKEVSEWM-KGQRGY----D-SVVWNRLYSRDAVCSILDETLQAVG-----AKSMVVGHTPQTG-VNCKYNCNIWRIDVGMSSGSRPEVLEIIDNQAKVIRCKRDGRTILAVGDLHGDLKQARYALEMAGVLSLWTGGENVLIQLGDILDRGEDEIAILSLLRSLDKQAKSKGGAVFQVNGNHETMNV---------------EGD---FRYVDSGGFDECSDFRSILFRPGGPLACE-LAGVALKVNDWVFCHGGLLPHHVYGLERMNKEVSEWM-RDPRGY----D-SVVWNRLYSRDSVCSVLEETLQAVD-----AKAMVVGHTPQIG-VNCKYNCSIWRVDVGMSSGSRPEVLEIIDDKARVIRSKTDGRRIVAVGDLHGDLEQARRAFQMAGVLSTWTGKETVLVQLGDILDRGENEIAILSLLRSMDKQAQEDGGAIFQINGNHETMNV---------------EGD---FRYVESGAFEECAGFRSVLLRPGGPLACE-LAAVVLKVNDWIFCHGGLLPHHVYGIERMNFEVSNWM-RGLRGY----D-SVVWSRLYSRDVIQSILEETLQAVN-----AKAMVVGHTPQAG-VNCKYNCSIWRIDVGMSSGSRPEVLEIVDGKARAIKGRRDGRRIVAVGDLHGDLEQARRAFQMAGVLSTWTGKETVLVQLGDILDRGENEIAILSLLRSMDKQAQEDGGAIFQINGNHETMNV---------------EGD---FRYVESGAFEECAGFRSVLLRPGGPLACE-LAAVVLKVNDWIFCHGGLLPHHVYGIERMNFEVSNWM-RGLRGY----D-SVVWSRLYSRDVIQSILEETLQAVN-----AKAMVVGHTPQAG-VNCKYNCSIWRIDVGMSSGSRPEVLEIVDGKARAIKGRRDARRIVAVGDLHGDLKQTRLALEMAGVLGLWTGGQTVLVQLGDILDRGEDEIAILSLLRSLDVQARAQGGAVFQVNGNHETMNV---------------EGD---FRYVDSGAFDECLNFRSILFRPGGRLARE-LAAVVLKVNDWVFCHGGLLPHHVYGIERMNREVSQWM-KGLRGY----D-SVVWNRLYSRDFINSILKDTLEAVG-----AKAMVVGHTPQAG-VNCKYNCSIWRVDVGMSSGSRPEVLEIRDDKVRVIRSKRDARRIVAVGDLHGDLKQTRLALEMAGVLGLWTGGQTVLVQLGDILDRGEDEIAILSLLRSLDVQARAQGGAVFQVNGNHETMNV---------------EGD---FRYVDSGAFDECLNFRSILFRPGGRLARE-LAAVVLKVNDWVFCHGGLLPHHVYGIERMNREVSQWM-KGLRGY----D-SVVWNRLYSRDFINSILKDTLEAVG-----AKAMVVGHTPQAG-VNCKYNCSIWRVDVGMSSGSRPEVLEIRDDKVRVIRSKRDGRRIVAVGDLHGDLDQTRSALRIAGVLSRWTGGQTVLVQLGDVLDRGGGEIAILSLLRSLDVQARLQGGAVFQINGNHETMNV---------------EGD---FRYVDSTGFDECLDFRSTLLRPGGALACE-LAGVLLKINDWVFCHGGILPHHVHGVERMNREVSQWM-KGLRGY----D-SVVWNRLYSQDLIEAALYDTLGSLD-----AKGMVVGHTPQRG-ANCECNGRIWRVDVGMSKGSRPEVLEINESKTRVLRLGRDGRRIVAVGDLHGDLYQTRAALVMAGVLSLWTGGQTVLVQVGDILDRGEDEIAILSLLSSLNMQAKSQGGAVFQVNGNHETMNV---------------EGD---FRYVDPGSFDECMRYRASLLKQGGPLACE-LAPVVLVVNDWIFCHGGLLPHHVYGLERINKDVSNWM-QGSRGY----D-SVVWTRFYSQDSSSLVAEQTLKSVG-----AKGMVVGHTPQRG-VNCKCDGKVWCVDVGMSYGSRPEVLEIINDRARVIKDRRGGRRIVAIGDAHGDLSQTRAALVLAGVLSVWTGGRTVLVQVGDILDRGEDEIAILSLLSSLSVQAKSQGGAVFQVNGNHETMNV---------------EGD---FRYVYPGGFDECIRFRSSLFKRGGPLACE-LAPVVLKINDWIFCHGGLLPHHVYGIERMNIEVSTWM-KSSRGY----D-SVVWSRMYSQDSSSIIAEETLKSVG-----AKGMVVGHTPQRG-VNCKCDGKVWCIDVGMSYGSRPEVLEIVNDRPRVLKKRRDGRRIVAIGDAHGDLSQTRAALVLAGVLSVWTGGRTVLVQVGDILDRGEDEIAILSLLSSLSVQAKSQGGAVFQVNGNHETMNV---------------EGD---FRYVYPGGFDECIRFRSSLFKRGGPLACE-LAPVVLKINDWIFCHGGLLPHHVYGIERMNIEVSTWM-KSSRGY----D-SVVWSRMYSQDSSSIIAEETLKSVG-----AKGMVVGHTPQRG-VNCKCDGKVWCIDVGMSYGSRPEVLEIVNDRPRVLKKRRDGRRIVAIGDVHGDLSQTRAALVLAGVLSVWTGGRTVLVQVGDILDRGADEIAILSLLSSLNVQAKPQGGAVFQVNGNHETMNV---------------EGD---FRYVDPGGFDECMRFRSSLFKRGGPLACE-LAPVVLKINDWIFCHGGLLPHHVYGIGRMNREVSRWM-KSSRGY----D-SVVWSRLYSQDSSSIVAEETLESVR-----AKGMVVGHTPQHG-VNCKCDGKVWCIDVGMSYGSRPEVLEIVNDSPRVLKKRRDDRRIVAIGDVHGDLSQTRAALVLAGVLSVWTGGRTVLVQVGDILDRGKDEIAILSLLSSLNLQAKSQGGAVFQVNGNHETMNV---------------EGD---FRYVDPGGFDECIRFRSSLFKRGGPLACE-LAPVVLKINDWVFCHGGLLPHHVYGIERMNREVSMWM-KCSRGY----D-SVVWSRLYSHDPSSIVAEQTLKSVG-----AKGMVVGHTPQGG-VNCKCDGKVWCVDVGMSYGSRPEVLEIVNDRPRVLKKRRDGRRIVAIGDVHGDLSQTRAALVLAGVLSLWTGGRTVLVQVGDILDRGEDEIAILSLLSSLNMQAKSQGGAVFQINGNHETMNV---------------EGD---FRYCDPGGFDECVRFRSSLLKRGGPLACE-LAPVVLKINDWIFCHGGLLPHHVYGIERMNREVSIWM-KCSRGY----D-SVVWSRLYSQDPSSIVAEQTLEAVG-----AKGMVVGHTPQHG-VNCKCDGKVWCVDVGMSSGSRPEVLEIVNDRPKVLKKRREGRRIVAIGDAHGDLSQTRAALVLAGVLSVWTGGRTILVQVGDILDRGEDEIAILSLLSSLNMQAKSQGGAVFQVNGNHETMNV---------------EGD---FRYCDPGGFDECMRFRSSLLKRGGPLAHE-LAPVVLKINDWIFCHGGLLPHHVYGIERMNREVSMWM-KCSRGY----D-SVVWSRMYSQDPSSIAAEQTLEAVG-----AKGMVVGHTPQHG-VTCKCDGKVWCVDVGMSCGSRPEVLEIVNDRPRVLKERREGRRIVAVGDLHGDLNQTRAALVMAGLLSVWTGGQTVLVQVGDILDRGEDEIAILSLLSSLNMQAKSQGGAVFQVNGNHETINV---------------EGD---YRYVDPGAFDECIRFRSSLFKRGGPLACE-LAPVVLSVNDWIFCHGGLLPHHVYGIERMNREVSVWM-KSSRGY----D-SVVWSRLYSQGPSSVVAERTLKSVG-----AKGMVVGHTPQRG-VN-------WYLL--FSLG---------------------DRRIIAIGDLHGDFERAQWALQLAGVMSRWTGGTTVLVQIGDVLDRGEDEITILSLLAWLGKQARSKGGAVFQILGNHETMNV---------------AGD---FRYVAPGGFQEAEAFRTKLLSPGGPLARQ-LAGVVLKVNDWLFAHGGVLPHHVYGLERMNREVSLWM-KNIKGF----D-SIVWSRLYSKENACGILTAALSATN-----SRGLIVGHTPQIG-ANSKCDGRIWRIDVGMSSGALPEVLEIVDDKVRILSVAEENRRIVSIGDLHGDFERAQEALELAGVLSRWTGGTTILVQIGDVLDRGEDEIAILSLLALLGREARSKGGAVFQLLGNHEAMNV---------------AGD---FRYVAPGGFLEAEVFRTKLLSPGGPLATH-LAGVVLKVNDWLFAHGGVLPYHVYGLERMNREVSLWI-QKEKGY----D-SVVWSRLYSKENACGTLAAALSATN-----SRGLVVGHTPQIG-GNSKCDGRVWRIDVGMSSGALPEVLEIVDDKVRILCAREEERRIVAVGDLHGDLRQTKRALRVAGVLSNWTGGTTVLVQVGDILDRGPDEIAILSLLWHLTEQARSKGGAVFQVHGNHETMNV---------------SHE---FNDTPDCGFEDSQHFRVLLFSPGGPLALE-LSGVVLKINDWLFAHGGLLPHHVYGLEKMNSEVSNWM-KGGKGF----D-SIVWSRLYSRKTACAVLQQTLDAVK-----AKGLVIGHTPQNG-ANSECDGKVWRIDVGMSRGATPQVIEIVGDEVKVLSCQKETGRIIAIGDLHGDLDKAVEALKLGRVISSWVGGDTVVVQLGDVLDRGDVEIGIINLLRYLDTEARKQGGAVYMLNGNHESLNV---------------CGD---FRYVTPGAFAESALYRYSLYKPGGDLARE-FSPTVLVVNDTVFAHGGLLPTHVYGIERLNSEVAAWM-RGDGDA----N-SVMWNRTLSKERACNALKQALAKVR-----GKRLVVGHTPQGG-VNCECENQVWRIDVGMSYGRPVQVIEIVPPEVRVIRNTPNTGRIVAIGDLHGDLDKAVEALKLGRVIRAWVGSDTVVVQLGDVLDRGDVEIGIINLLRYLDSEARKCGGAVYMLNGNHESLNV---------------CGD---FRYVTPGAFAESAMYRYSLFKPGGDLAKE-FAPTVLVVNDTVFAHGGLLPIHVYGIERLNSEVAAWM-RGDGDA----N-SVMWNRTLSKERACRALQQALAKVH-----GKRLVVGHTPQSG-VNCECENQVWRIDVGMSYGRPVQVLEITQHEVRIIRSTPTTGRIIAIGDIHGDLQKALSCLEMAGVLAKWVGGDTVVVQLGDVLDRGDCEIGSVLLLRELDRQARQQGGAVYMLNGNHESLNV---------------AGD---FRYVTPGAFFESARARWYLYQPGGAMARE-LAATVLVVNDVVFAHGGLLPHHLYGLQRINDEVAEWM-NGAGDS----S-SVQWNRTFGKERMNFQLRATLESLN-----ARAMVVGHTPQSG-VNCECDGRVWRVDAGMSSGAAPQV----------------SGRIIAIGDIHGDVQKAITSLKLGGVLVVWCGGNTVVVQLGDVLDRGDSEIGAIILLRELDRQARLQGGAVYMLNGNHESLNL---------------LGAAMWRRYVTPGGFRESGLVRLHLYSPGGRLACE-LAPTVLIINDTVFAHGGVLPNHVYGLERLNAEVAAWM-RGAGGP----D-SVMWNRQFGHERACMDLDATLRLLG-----ARQLIVGHTPQNG-ANCECNGRVWRMDVGMSKGAAPQVLEIEPEDIRLLCPPSVKGRVVALGDVHGDIGQARRALTIAGVLGTWIGGDTVVVQVGDVLDRGDDEIAILILLQKLHKAAQADGGAVYILNGNHEVLNV---------------SGD---FRYVTQGAFQESTRFRVGLFSPGGPLAQQ-LASTVLIVNDTVFAHGGLMPRHVFGLEKLNNAVADWM-RGAGSK----D-SVVWNRTFGQENACETLGKTLDAID----GAKRLVVGHTPQGG-CNAECDGRIWRIDVGMSFGADPEVIEIVGDEVRVLTSRVPPGRVVALGDVHGDIGQARRALTIAGVLGEWTGGNTVVVQVGDVLDRGDDEIAILILLQKLHKQAEAQGGAVYILNGNHEVLNV---------------SGD---FRYVTQGAFQESARFRVGLFSPGGPLAQQ-LASTVLIVNDTVFAHGGLMPRHVFGLERLNNAVADWM-RGAGSK----D-SVVWNRTFGTENACEVLGNTLDAISEKYGAAKRLVVGHTPQGG-CNGECDGRIWRIDVGMSFGADPEVIEIDGDEVRVLNSRVP-GRVVAIGDLHGDIGQARRALRMAGVLDRWVGGDTTLVQLGDILDRGDDEIGILILLQKLDKEAQKQGGRVYVMNGNHEVLNV---------------SGD---FRYVSRGAFGESTRFRIGLFSPGGPLAQQ-LSHTVLIVNDTVFAHGGLVPRHVFGLDKLNRAVTDWM-RGKGGR----D-SIVWHRAYGTEKSCELLGKTLGMID----GVSRLVVGHTPQGG-ANCECNGQIWRIDVGMSFGAEPQVLEIDGDEVRVLSSSSVPGRVIAIGDLHGDIGQARRALRLAGVLGTWVGGDTTVVQVGDILDRGDDEIGILILLQKLEKEARKQGGGVYVLNGNHEVLNV---------------SGD---FRYVSRGAFGETMRFRIGLFSPGGPLAQQ-MSHTVLIVNDTVFAHGGLVPRHVFGLDKLNRAVTDWM-RGKGGR----D-SIVWHRGYGTERSCALLGETLGMID----GANRLVVGHTPQGG-ANCECDGRIWRIDVGMSFGADPQVLEIDGQEVRVLTPTNMFGRTVEVSDLAGAMGQARRLPHMRRYRAAWVGGNATLVQLGDILDRGDDEIGILILLQKLDKEAKKAGGAVYVMNGNHEVLNI---------------SGD---FRYVTRGAFGETTRFRIGLFSPGGPLAQQ-LSHTVLIVNDTVFVHGGLVPRHVYGLDKLNRAVSDWM-RGKGGR----D-SIVWHRGYGTENSCELLEKTLGMID----GANRMVVGHTPQGG-ANCECDGKIWRIDXXXXXXAEPQVLEIDGGDVRVITSASS-----------------MKALECAKVMDKWCGGDTVVVQVGDILDRGDNELAIMRKFRALAKDARAAGGDFIVINGNHEIMNV---------------LGD---FRYVTKGAYGECARYRRALFLPGGEMAVK-MAPTVLQVDDTVFAHAGIDESHVYGFARINAEVSQWM-AGSLEE----K-GVVWTREYGGADACRRLEKALDATG-----AKRIVIGHTPQKG-VNSGCGGKVWRADVGASRGNTPQVIEIVNGRVRVLSA---GRRLVAVGDIHGDFAQAMKALELSKCMNKWIGGTTVLVQVGDILDRGDNELAIMRKFQKLAKEAKEAGGDVVVMNGNHEIMNV---------------MGD---FRYVTKGAFGECRRWRRDLFLPGGEMAVK-MAPTVLQVGDTVFAHAGITENHVYGFQRLNNEVAAWM-VGKLEE----K-GVVWTRDYGGAEACKRLTEALDATG-----AKRLIVGHTPQKG-INSGCGGKVWRSDTGMSRGNTPQVIEIVNGRVRIL-----GRRLIAIGDLHGDFLAMVKSLELAQVIDKWNGGDAVVVQVGDVLDRGDSEIAILRKLRSLAKQAKEAGGDLITMNGNHEIMNV---------------MGD---FRYATPGAFEECRRYRQQLFKPGGEIAKW-LAPTVLVVDDTVFAHAGIDLSHVYGFERINKEVAMWM-EGKLES----D-GVVWTRDYGGKDSCRRLASALEGAD-----AKRLVIGHTPQTG-VTSGCKGTVWRVDVGASRGNSAQVIEIIGGKVRVLA----GRRLVAVGDLHGDFLAAVRALELAGVMDKWVGGDAVVVQVGDVLDRGDSEIAIMRKLRALRKQARQVGGDVVCMNGNHEIMNV---------------MGD---FRYATPGAFEECRRYRQQLFKPGGELAMW-LAPTVLVVDDTVFAHAGIDLSHVYGFERINKEVSMWM-QGKLES----D-GVVWTRDYGGKDACRKLNTALDAAG-----AKRLVIGHTPQTG-VTNGCKGALWRVDVGASRGHDVQVIEIVNGRTRVLA----GRRLIAIGDLHGDFLAMVRSLELAGVCDKWIGGNAVVVQVGDVLDRGDSEIAILRKLRALKRQAKEQGGDVITMNGNHEIMNV---------------MGD---FRYATPGAFEECRLYRQKLFSPGGEIAKW-LAPTVLVVDDTVFAHAGIDLSHVYGFERINREVSLWM-QGKLES----D-GVVWTRDYGGKDACRRLGAALDAAE-----AKRLVIGHTPQTG-VTSGCKGAVWRVDVGASRGNAAQVIEVIGGRVRVLA----ADRVVAIGDVHGDLAATRAALRIAGAIDRWIGGKLVLVQTGDELDRGDDEQTIVDLFDRLAVEARAAGGAVYALNGNHEVMNV---------------QLD---FRYVTEGGFKDFEDVRAAAFAPGGLYARK-LADVIIAVGDTVFTHGGVLPAHTYGISRINREVRAWM-EGKAAE----D-SPVWARLYSSDPPCAALDQTLAAMS-----AKRMVVGHTVQHG-ATSACGDKIWRIDVGMASHGKPAALEIVGDTVRVLTPEATPARVVAIGDLHGDLDAALRALSLAGAIALWTGGDMVLVQTGDVLDRGDDEQAILDLLARLEREARAAGGAVHALLGNHETMNA---------------AGD---FRYVTPGGFSDFADARAAAFLPGGVYAER-LANTVVVVGDTVFAHGGVVPRWAYGIERVNAELRCWL-AGELAE----D-NPMWSRDFSREPACDALERALAALD-----ATRMVVGHTPQDG-ITSACDGRVWRIDTGMAAHGAVQALELRGDSARILSEDE---------------------------MDKWIGGSLVIVQTGDQLDRGDGEQAILELLARLQHEAKAAGGAIHILNGNHEFMNA---------------MGD---LRYVTPGGLVDFADARVAAFLPGRPWAKE-LGNTVVVVGDTAFVHGGVLPAYAGDITTLNREARAFL-NGEVDP----D-GPVWSRHYSDE-DCALLDQALAKLE-----VKRMVVGHTVHEG-IQSACDEKVWMVDVGMAAHGPTQVLVIAGAEVSVLAG---VPHIIAFGDVHGDFVAMAEVLLGAGIVDHWIAGETWVVQVGDQLDRGYQEEEIMNLFEQLRVEAAEAGGRFLALNGNHEIMQA---------------EGR---MDYVFD--LEAFGGLRVEAFAPGGEWALV-LANVIVKVGRTVFVHGGALPEHALGIENMNDAAKAWL-VGDDGS----G-SIVWDRTYSDDDRCELLTAALAAMD-----ADRIVVAHTIQPG-INAICDDRAWRIDTGMADYGPIEALEITGDVASVIQME--PERLVAVGDLHGDLDKSREAFKIAGLIDRWTGGSTMVVQVGDVLDRGGEELKILYFLEKLKREAERAGGKVLTMNGNHEIMNI---------------EGD---FRYVTKTGLEEFQVWRIAALRPEGPISKRFLTQTVAVVGDSVFVHGGLLAEHIYGLERINEEVRGWI-NGLRGG----N-SVVWLRKFSEEMDCAALEHALSTIG-----VKRMIMGHTIQAG-INGVCNDKAIRIDVGMSKGGLPEVLEIRR-DVRILTSNPLPERLVAIGDLHGDLEKSREAFKIAGLIDRWTGGSTMVVQVGDVLDRGGEELKILYFLEKLKREAERAGGKILTMNGNHEIMNI---------------EGD---FRYVTKKGLEEFQIWRIAALRPDGPIAKRFLTQTVAVVGDSVFVHGGLLAEHIYGLERINEEVRGWI-NGFRGG----N-SVVWLRKFSEEMDCAALEHALSTIG-----VKRMIMGHTIQAG-INGVCNDKAIRIDVGMSKGGLPEVLEIRR-DVRIVTSNPLPERLVAIGDLHGDLEKSKESFRIAGLIDRWTGGSTVVVQVGDVLDRGGEEIKILYFLEKLKREAERSGGKVLTMNGNHEIMNV---------------EGD---FRYVTKKGLEEFQIWRIAALRPEGPIAKRFLTQTVAVVGDSVFVHGGLLAEHIYGLERINEEVKGWI-NGLRGG----N-SVVWLRKFSEEMDCAALEHALSTIG-----VKRMIMGHTIQAG-INGVCNDKAIRIDVGMSKGGLPEVLEIRR-DVRIVTSNPLPERLVAIGDLHGDLDKSKEAFRIAGLIDKWTGGSTMVVQVGDVLDRGGEELKILYFLEKLKREAEKSGGKILTMNGNHEIMNV---------------EGD---FRYVTEKGLEEFQIWRIAALRPEGPIAKRFLSQTVAVVGDSLFVHGGLLAEHIYGLERINEEVTCWI-NGLRGG----N-SVVWLRKFSDEMDCSALEHALSTIG-----VKRMIMGHTIQAG-INGVCDNKAIRIDVGMSKGGLPEVLEIRK-DVRIVTSNPLPDRLVAIGDLHGDLEKSKEAFRIAGLIDRWTGGSTMVVQVGDVLDRGGDELKILYFLERLKREAEREGGRVVTMNGNHEIMNI---------------EGD---FRFVTKEGLEEFRVWRIAALRPQGPIAKRFLSQTVAVVGDSVFVHGGLLAEHVYGLERMNEEVTSWI-NGLRGG----N-SVVWLRKFSDERDCAALEHALSTIG-----VRRMIMGHTIQAG-INGVCGDKAIRIDVGMSKGGLPEVLEIRK-DVRIVTSNPLPERLIAIGDLHGDFDKSKQAFRIAGLIDKWIGGSTTVVQIGDVLDRGGNELKILYFIEKLKREAAKTGGKIITMNGNHEIMNM---------------EGD---FRFVTKEGLDEFRVWRIAALRPEGPISRRFFTVTVLVVGDSIFVHGGLLPEHVYGLERINQEVRNWI-NGSRGR----D-GVVWVRRFSREQDCSALEHVLATVG-----VKRMIMGHTIQSG-INGACNNRAIRIDVGMSSGGLPEVLEIDR-NLQVLTSNTIVDRLIAIGDLHGDLEKSKQALRLAGLINQWTGGTATVVQIGDVLDRGDDEIKILYLLEKLKREAEKSGGKFITMNGNHEIMNI---------------EAD---FRYATEMGLKEFEDWRIAALRPDGPIARRFLSTTVLVVGDSVFVHGGLLKQHVYGLERINREVRDWI-NGLKGR----H-AVVWLRKFSDE-DCSALEHALATLG-----VKRMIMGHTIQKG-INAVCDNRAIRIDVGLSRGGLPEVLEING-NLLVLTANPLVDRLIAIGDLHGDLEKSKQALRLAGLINQWTGGTATVVQIGDVLDRGDDEIKILYLLEKLKREAEKSGGKFITMNGNHEIMNI---------------EAD---FRYATEMGLKEFEDWRIAALRPDGPIARRFLSTTVLVVGDSVFVHGGLLKQHVYGLERINREVRDWI-NGLKGR----H-AVVWLRKFSDE-DCSALEHALATIG-----VKRMIMGHTIQKG-INAVCDNRAIRIDVGLSRGGLPEVLEING-NLLVLTANPLPDRLIAIGDLHGDLEKSKQALRLAGLIDRWFGGSATVVQIGDVLDRGDDELKILYFLEKLKREAVKSGGNLITMNGNHEIMNV---------------EGD---FRYMTKLGLEEFTNWRIAALRPNGPIANRFLSLTVLVVGDSVFVHGGLLAEHVYGLARMNKEVSDWI-TGLRGR----N-AVVWLRKFSDEVDCAALEHVLATIG-----VKRMIMGHTIQAG-INGVCENKAIRIDVGMSRGGLPEVLEING-NLRVLTSNPLPNRLVAIGDLHGDLEKSKQAFRLAGLIDRWSGGSATVVQIGDVLDRGGEELKILYFLEKLKREAVKSGGNLITMNGNHEIMNV---------------ESD---FRYVTKVGLEEFSNWRIAALRPDGPIANKFLSVTVLVIGDSVFVHGGLLAKHVYGLERMNQEVRDWI-TGLRGR----E-AVVWLRKFSDEVDCSALEHVLATIG-----VKRMIMGHTIQAG-INAVCDNRAIRIDVGMSKGGLPEVLEING-KLRVLTSNPWPDRLIAIGDLHGDLEKSKQALRLAGLIDKWAGGSATAVQVGDVLDRGDDEIQILYFLEKLKREAMKDGGNFITMNGNHEIMNI---------------EGD---FRYVTKLGLKEFEDWRIAALRPNGPIANKFLSVTVLVVGDSIFVHGGLLAQHVYGLERINEEVRDWI-SGLRGR----N-AVVWLRKYSDV-DCSMLEHVLATVG-----VKRMIMGHTIQDG-INVACNNRAVRIDVGMSKGGLPEVLEINQ-NLRVLTSNPLPNRLVAIGDLHGDLEKSKQAFRLAGLIDRWCGGSTTVVQIGDVLDRGGEELKILYFLEKLKREAVKSGGQLITLNGNHEIMNI---------------EGD---FRYVTKKALEEFDVWRIAALRPDGPISRRFLALTVLVVGDSVFVHGGLLEKHVYGLQRINDEVRDWI-NGLRGR----N-AVVWLRKFSDEFDCSLLEHVLATIG-----AKRMIMGHTIQIG-INGACDNRAIRIDVGMSKGGLPEVLEIDR-NLRVLTSNPMPDRLIAVGDLHGDLSKSKEALRLAGLIDRWIGGSATVVQIGDVLDRGGDELKILYFLEKLKREAAKDGGMIITMNGNHEIMNV---------------EGD---FRYVTKEGLEEFRAWRIAALHPNGPISGRFLSTTVLVVGESVFVHGGLLPGHVYGLQRINEEVRDWI-KGLRRS----N-AVVWLRKFSDESDCSLLKHVLDTIG-----AKRMIMGHTIQAG-INGVCNNQAIRIDVGMSKGGFPEVLEFVG-NPRILTSNPYPPRLVAIGDLHGDLEKSKEALRLAGLIDRYTGGSATVVQIGDVLDRGGDELKILYFLEKLKREAARRGGRIITMNGNHEIMNV---------------EGD---FRFATLPGVEEFRVWRVAALRPNGPIAKRFLSVTVLVVGDSIFVHGGLLPQHTYGLEKINEEVRDWV-NGSRGA----D-GLVWVRKFSRGDDCSALEHVLSTVG-----VKRMVMGHTIQVG-INGVCDDKAIRIDVGLSKGGLPEVLEISG-SLRILTGNPLPPRLVAIGDLHGDLEKSKEALRLAGLIDRYTGGSATVVQIGDVLDRGGDELKILYFLEKLKREAARRGGRIITMNGNHEIMNV---------------EGD---FRFATLPGVEEFRVWRVAALRPNGPIAKRFLSVTVLVVGDSIFVHGGLLPQHTYGLEKINEEVRDWV-NGSRGA----D-GLVWVRKFSRGDDCSALEHVLSTVG-----VKRMVMGHTIQVG-INGVCDDKAIRIDVGLSKGGLPEVLEISG-SLRILTGNPLPPRLVAVGDLHGDLEKSKQALRLAGLIDRYIGGSATVVQVGDVLDRGGEELKILYFLEKLKREAARSGGRIVTMHGNHEIMNV---------------EGD---FRFATESGVEEFRVWRVAALRPNGPIATRFLSVTVLVVGDSIFVHGGLLPEHSYGLEKINEEVRDWV-KGLRSA----D-GLLWLRKFSRSKDCSALEHVLATVG-----VKRMVMGHSIQVG-INGACDDKAIRIDVGLSKGGLPEVLEISR-NLRILTEDPLPSRLIAIGDLHGDLKKSKEALSIAGLIDNYTGGSATVVQIGDVLDRGGDEIKILYLLEKLKRQAAIHGGNFITMNGNHEIMNA---------------EGD---FRFATKNGVEEFKVWRVAALRPNGPISKRFFTVTVLVVGDSIFVHGGLLKEHVYGLEKINGEVSDWY-KGLRGR----N-ALVWLRKFSD--DCSSLEHVLSTIG-----VKRMIMGHTIQEG-INGVCENKAIRIDVGMSKGGLPEVLEIDR--VRILTSNPLQDRLVAIGDLHGDLEKTKESLRLAKLIDKWVGGSTTVVQIGDVMDRGGDEIKILYYLEKLKREAARCGGTVITMHGNHEIMNV---------------EGD---FRFVTRKGLEEFRVWRIAALRPSGPISSRFLSVAVLVVGDSVFVHGGLLSQHVYGLEKINEEVRDWI-HGLHGA----N-GVVWLRKFSLGLDCSALEHVLATIG-----AKRMIMGHTIQFG-INGVCNERAIRIDVGMSKGGLPEVLEIKG-NMRILTSNPLQDRLVAIGDLHGDLEKTKESLRLAKLVDKWVGGSTTVVQIGDVLDRGGDEIKILYYLEKLKREAARCGGTVITMHGNHEIMNV---------------EGD---FRXVTRKGLDDFRVWRIAALRPSGPISSRFLSVAVLVVGDSVFVHGGLLGQHVYGLEKINEELREWI-HGLRGA----N-SVVWLRKFSHEYDCSALEHVLATIG-----AKRMIMGHTIQFG-INGVCNERAIRIDVGMSKGGLPEVLEIKG-NLRILTSNPLQDRLVAIGDLHGDLEKTKESLRLAKLVDKWVGGSTTVVQIGDVLDRGGDEIKILYYLEKLKREAARCGGTVITMHGNHEIMNV---------------XXD---FRXVTRKGLDDFRVWRIAALRPSGPISSRFLSVAVLVVGDSVFVHGGLLGQHVYGLEKINEELREWI-HGLRGA----N-SVVWLRKFSHEYDCSALEHVLATIG-----AKRMIMGHTIQFG-INGVCNERAIRIDVGMSKGGLPEVLEIKG-NLRILTSNPLQDRLIAIGDLHGDLEKTKESLRLAKLIDKWVGGSSTLVQIGDVFDRGGDELKILYYLEKLRREAARCGGTVITMHGNHEIMNV---------------EGD---FRFATHKGLDEFRGWRVAALRPNGPISSRFLALTVLVVGDSVFVHGGLLAAHVYGLEKINAEVRDWV-HGLRGR----N-AVVWLRNFSHEFDCSALEHVLSTIG-----AKKMIMGHTIQFG-INGVCEERAIRIDVGMSKGGLPEVLEING-NMRILTSNPLPSRLIAIGDLHGDLDKTKQAFHLAGLIDRWSGGSSTVVQVGDVFDRGGDELKILYFLEKLKREAAKSGGELITMNGNHEIMNV---------------EAD---FRFVTRSGLQEFEDWRIAALRPGGPVSTRFLTQTVVVVGDSVFVHGGLLSNHVYGLERINDEVREWL-SGSRGR----D-AVVWLRRFSEEADCSALEHVLATIG-----VKRMIMGHTIQSG-INGICGNKAIRIDVGLSKGGLPEVLEIDGTNLRILTANPLPSRLIAIGDLHGDLEKTKQAFRLAGLIDRWSGGSSTVVQVGDVFDRGGDELKILYFLEKLKREAAKSGGELITMNGNHEIMNV---------------EAD---FRFVTRSGLQEFEDWRIAALRPGGPVSTRFLTQTVVVVGDSVFVHGGLLSNHVYGLERINDEVREWL-SGSKGR----D-AVVWLRKFSEEADCSALEHVLATIG-----VKRMIMGHTIQGG-INGICENRAIRIDVGLSKGGLPEVLEIDGTNVRILTANPLPDRLIAIGDVHGDLEKTKEAFRIGGLIDRWIGGSTTVVQVGDVLDRGGEEIQILYFLEKLKREAARSGGKIITMNGNHELLNV---------------DGN---FKFTTADSLKEFKKWRIAALRPGGPITRRFLSATVLVIGDSIFVHGGLSSKHLYGLDRINEEVKDWM-NGL-GE----D-GVVWMRKFSVKKDCSALEHLLTTVG-----VQRMIMGHTPQ-R-INDECDGKAIRIDVGMSRGRLPEVLEITR-GLKILSSSPAPDRLIAVGDLHGDLQKSKEALRLAALIDRWTGRTATVVQIGDVLDRGGDELKILYFLEKLKREAEKSGGTIITMNGNHEIMNV---------------DGD---FRFVTQAGLDEFRVWRIAALRPEGPISVRFLSQTVVVVGDSVFVHGGLLPKHVYGLERINEEVRDWI-NGLRGK----H-SMVWLRKFSHELDCSTLEHVLATIG-----AKRMIMGHTIQTG-INGACGNRAIRIDVEADR----------------------PNRLVAIGDLHGDLDKSKQAFKIAGLIHRWIGGNTTVVQIGDVFDRGDDELKILYFLEKLKREALRSGGSIITMIGNHEIMNI---------------DGD---FRYITPSGLQEFKAWRIAALRPNGPISTRFLSPTALVVGDSVFVHGGLLQDHVYGLERINEEVRDWI-NGLRGR----N-SVVWLRKFSDQVDCSTLQHVLATIG-----AKRMIMGHTIQMG-INGVCDNQAIRIDVGMSKGGLPEVLEIIG-NVRILTSEKVPSRLIAIGDLHGDLPKAKQALRLAGLVGRWSGGSATVVQVGDIFDRGGDEIKLLYFFEKLKREAAGAGGLVITMNGNHEIMNV---------------EGD---FRFAAREGFEEFENWRIAALRPNGLISSRFLSQTVVVVGDSVFAHGGLLQNHVYGLDLINEEVRDWI-LGLRGR----D-SIVWLRSFSNELDCSMLEHVLETIG-----VKRMIMGHTIQNG-INTVCGNRAVRIDVGMSRLRFPEVLEIGE-NLKVLTSNPLPSRLVAIGDLHGDLAKSLAALRLAGLLPSWAAGPTLAVQLGDILDRGGDELRLLYFLRRLSISAAAQGGALLPILGNHEVMNV---------------AGD---YRFVTPEGLREFSAWRLAALRPEGPIARRFLAPTVLVVGDSVFVHGGLLEAHVYGIERINAEVSDWI-RGGSGR----D-AVVWLRRFSEGFDCQRLQGVLGMLG-----TKRMVMGHTIQEG-INAVCGAQAVRVDVGLSRGGLPEVLEINGGGVRVITTDPAPTRLVAIGDLHGDLPKSLSALRLAGLVPSWSAGPTLAVQLGDILDRGGDEIRLLYLIRRLAISAAGQGGALLPIMGNHEVMNV---------------SGD---FRFATPQGLREFSAWRLAALLPDGPIARRFLAPTVLVVGDSVFVHGGLLEANVYGLERINAEVSEWI-RGERGR----D-AVVWLRRFSDGVDCQRLEGVLGMIG-----AKRMIMGHTIQEG-INAVCGAQAVRVDVGLSRGGLPEVLEINGGGVRVITTDPAPSRLVAIGDLHGDLPKSLSALRLAGLVPSWAAGPTLAVQLGDILDRGGDELRLLYLLRRLALSAEARGGALLPILGNHEVMNV---------------SGD---FRFATPQGLQEFSAWRLAALRPDGPIARRFLAPTVLVVGDSVFVHGGLLEANVYGLERINAEVSEWI-RGERGR----D-AVVWLRRFSDGFDCQKLEGVLGMIG-----AKRMVMGHTIQVG-INAVCGAQAVRVDVGLSKGGLPEVLEINGGGVRVITTPPSPSRLVAIGDLHGDLPKSLSALRLAGLVPSWAAGPTLAVQLGDILDRGGDELRLLYLLRRLALSAEARGGALLPILGNHEVMNV---------------SGD---FRFATPQGFQEFSAWRLAALRPDGPIARRFLAPTVLVVGDSVFVHGGLLEANVYGLERINAEVSEWI-RGERGR----D-AVVWLRRFSDGFDCQRLEGVLGMIG-----AKRMVMGHTIQVG-INAVCGAQAVRVDVGLSRGGLPEVLEINGGGVRVITTPPSPSRLVAIGDLHGDLPKSLSALRLAGLVPSWAAGPTLAVQLGDILDRGGDELRLLYLLRRLALSAEARGGAFLPILGNHEVMNV---------------SGD---FRFATPQGLQEFSAWRLAALRPDGPIARRFLAPTVLVVGDSVFVHGGLLEANVYGLERINAEVSEWI-RGERGR----D-AVVWLRRFSDGFDCKRLEGVLGMIG-----ARRMVMGHTIQVG-INAVCSAQAVRVDVGLSRGGLPEVLEINAGGVRVITTPPSLSRLVAIGDLHGDLPKSLSALRLAGLVPSWAAGPTLAVQLGDILDRGGDELRLLYLLRRLSLSAESRGGAFLPILGNHEVMNV---------------SGD---FRFATPQGFQEFSAWRLAALRPDGPIARRFLAPTVLVVGDSVFVHGGLLEANVYGLERINAEVSEWI-RGERGR----D-AVVWLRRFSDGFDCKRLEGVLGMIG-----AKRMVMGHTIQVG-INAVCSAQAVRVDVGLSRGGLPEVLEINAGGVRVITTPPSPKRLIAVGDIHGDLAKARAALHVAEVIDHWIGGETVVVQVGDLLDRGGEEIKVIYLLEKLRGEAQKVGGNVHIMNGNHEIMNI---------------EGD---FRYATPLGLDEFQRWRIAALRPGGPLASRFLAPTVLVVGSSVFVHGGLLPVHVHGLERINQEVSEWM-LGTHGG----N-ALVWLRKYSDVKDCDLLKRCLGSIG-----AKRMVVGHTIQIG-LNGACDNKVIRVDVGLSKGGMPQVLEIRG-DLRILSSRLPVERLVAIGDIHGDLAKTRESLRIAGVVDRWIGGKTVVVQVGDVLDRGGQELKVLYLLERLKGEAQRHGGDLHIMNGNHEVMNI---------------EGD---FRYATKEALDEFSAWRYAALRPGGPISSRFLAPTILIVGSTVFAHGGILPSHLYGLEKINAEVRDWI-QGRRGK----D-AVVWARQYSIPVDCKLLDEVLTGIG-----ASRMVVGHTIQFG-INSACQNQVFRVDVGMSSGTAPEVLEIRH-DVRVLS----VRRLVAVGDLHGDLAKTKEALVAGGLMDRWSGGTTTAVQVGDQLDRGGDEVAILLLLERLRKEARDAGGELVVMNGNHETLNV---------------AGR---FRYATADGLEDFRRWRLAALAPGGPMARRFLAPLVVAVGSTVFAHGGVLPHHVYGLERINKETSDWV-RGNSGR----E-SVVWARDYSMPEDCDVLEASLSKMG-----MKRVVVGHTIQHG-VNAACDGKVLRVDVGMSKGGKPEVLEILDDGGVFRLSLDE-ERLVAIGDLHGDLNKATRAFRAGGLIDKWIGGATVAVQVGDQLDRGGDEVAILYMLERLRKEARDAGGELIVMNGNHETLNV---------------AGR---FRYAFEPGIEDFRRWRLAALAPGGPMAKRFLAPVVVAVGSTLFAHGGVLPHHVYGLERINQETSEWI-RGDSGG----R-SVVWARDYSWPQDCGVLRRALDGLG-----IDRVVVGHTIQEG-VNAACDGRVLRVDVGMSEGSEPEVLEIL------------VERLVAIGDVHGDLAKTREAFRAAKLTNEWVGGTTTCVQVGDQLDRGKDEVAILHFLERLRGEARAAGGELVVMNGNHETLNV---------------SGR---YRYSLAEGNADFTRWRWRALAPGAPLALRFLAPVVVAIGSTLFVHGGVLPEHVYGLDTLNEEISQWI-KRGQGR----D-SVVWARDYSHVQDCDLLEETLRMIG-----VERVVVGHTIQHG-ITSACDGKVIRIDVGMSKGAKPEALEILKDGIAKMKLGDDVERLVAIGDVHGDLSKVREAFRAAGMTNEWVGGSATCVQVGDQLDRGKDEVAILHFLERLRGEARDAGGELVVMNGNHETLNV---------------SGR---FRYSLPEGRADFARWRWRALAPGSPMTMRFLAPVVVAIGSTLFVHGGVLPEHVYGLDTLNAEISAWM-QRGQGR----D-SLVWARDYSHVQDCDLLKETLAMIG-----IERVVVGHTIQYG-ITKACDGQVIRIDVGMSKGAKPEALEILNDGI--------VERLVAIGDVHGDLDKTREAFRAARLTNEWIGGTATCVQVGDQLDRGKDEVAILHFLERLRTEARNAGGELIVMNGNHETLNV---------------AGR---YRYALTEGSADFARWRWRALAPGAPLTLRFLAPVVVAVGSTLFVHGGILPEHVYGLDSLNAEISTWM-KMGQGR----D-SLVWARDYSHVQDCDLLKETLKMIG-----VERIVVGHTIQHG-ITSACDGKVIRVDVGMSKGAKPEALEILRDGLTKLKVGADVPRLVAIGDLHGDLKKARRAFRLGGLTDRWIGGTTTAVQVGDQLDRGNDEVRILYFLERLEREAERAGGKLHILNGNHETMNV---------------AGR---FNYATLPGLADFYHHSEALHCSAGAVTARFLAPIALQIGSTVFVHGGVLPQHALGLERINQETRAWM-RGETGR----Q-AIVWAREYSAGADCAALEQVLGRLG-----AERMVVGHTIQAG-INSACEDRVFRIDVGLSKGGEPQV----------------VPRLVAIGDLHGDLRKARRAFRLAGLIDRWAGGTTTV--VGDLLDRGDQELPLLFFLERLQGQAAAAGGALHVLNGNHETMNV---------------AGQ---FRYVTHRGMHSFADWRILALQPGGEVTRRFLAPVVLQVGSTLFVHGGVLRQHVYGLERINRETQEWMLKGSSGR----G-AVVWSRHYSAAADCGQLAEVLGRVG-----AQRMVVGHTIQGG-INSACQGRVLRIDVGLSRGGSPEVLEIVN-DVRRLSESQQPPRLVAIGDIHGDYHKAVRALRLAGLMDRWAGGSTVAVQVGDILDRGDHEIRILILLERLAAEAAAAGGRLYLLNGNHETMNV---------------MGD---HRYATPGANLEFLGFR--ALMPGSELARRFFAPTVLQLGGNVFVHGGVLPAHVYGLEKINSETQSWM-LAPRGG----S-AIVWARAFSASDDCDTLKSVLESVG-----AQRMVVGHTIQRG-INSACESRVVRVDVGMSHGGPVEVLEVLK-DVLRLREHTPADRLVAIGDIHGDYHKAVRAFRLAGLTDRWSGGSTVAVQVGDILDRGDHEIRTLIMLERLAREAEAAGGRLYLLNGNHETMNV---------------MGD---HRYATPGANLEVLGLR--ALRPGSEISRRFFAPTVLQVGDNLFVHGGVLPAHVYGLERINRETQSWL-LGGLGG----S-AIVWARAFSASDDCETLQNVLESIG-----ARRMVVGHTIQRG-INSACESRVIRIDVGMSHGFPVEVLEVLK-DVRRLREHGP-----------------------------------------------------------------------------------------------------------------------CLTVLRPDGPISRRFMAPTVLVVGDSVFVHGGLLEANVYGLERINAEVSEWI-RGERGW----D-IVVWLRRFSDGFDCKRLEGVLGMIG-----AKRMVMGHTIQVG-INTVGRGPPPSTSVSVGRGAMAQTLATVG---RTLPQRGG-----------------------------------------------------------------------------------------------------------------------RLTALRPDGPISRRFLAPTVLVVGDSVFIHGGLLEANIYGLERINAEVSEWI-RGERGR----D-TVVWLRRFFDGFDCKRLEGVLGMIG-----AKRMVMGHTIQVE-INTVGRGPPPSTSVSVGRGAMAQTLATTG---RTLPQRGG-----------------------------------------------------------------------------------------------------------------------RLTALRPDGPISRRFLAPTVLVVGDSVFIHGGLLEANIYGLERINAEVSEWI-RGERGR----D-TVVWLRRFFDGFDCKRLEGVLGMIG-----AKRMVMGHTIQVE-INTVGRGPPPSTSVSVGRGAMAQTLATTG---RTLPQRGGVRRLLALGDVHGDLASLRKCLSLANVINEWIGGDAVVVQVGDVFDRGDAERAVLHFLDTLDRQARERGGAVYRLLGNHEVMNV---------------DLD---FRYVTPGGFAEFRRRRAMALAPGCPTARLLAEQLVLIIGDTLFVHGGLRPDHVYGLERLNAETRAWMERRAKGS----R-SPVWMRTYSAPHACRELEETLRRAG-----VRRMVVGHTPQ--VINGACRGRVWRVDTGMSAAGACEVLEISETHIRIFTDHGVPGRVVALGDLHGDAAAAVTALTAAGLIDHWSGGDATLVQLGDVLDRGGEEFALWGLLERLRLEARSAGGRVVTLLGNHEVLNA---------------LGKA--ATYVHPAGHAQFGDDRCAAFRPGGALAARLADPVVAVVGDSVFAHASLPRGATGSLARLNAETRAWL-LGEGGR----D-SPVWDRTFSAPGDCEALRDTLRGLG-----ASRLVVGHTPQ--RVNGACGGAVWRCDTGCSRWGPVEALEIQGGAVRVLRRGTAPKRIVAVGDLHGDIHATRQALRLAGVLHEWIGGDTFLVQVGDQVDRGDDEIQVMSLLHRLGKQARAEGGRVEVLVGNHELMSA---------------QGN---FRYATKGAMRNFQRWRYLSLRSGGTFASKFLAKAILIVGDTVFVHAGLLHKHFEAINVLNQEVAAFL-KGEWGN----D-GILWTRRFSKIDTCKQLKKTLNRLN-----VRRMVVGHSVQDG-ISPACDASVWRIDVGMSKGTSPQVLEIKQDGVNILGKSIEPDRLVAIGDLHGDIVATRRALRLAEVLHEWVGGKTVVVQVGDQLDRGDDELQILSLLRKLAVQARQHEGALHVLIGNHEILS----------------THT---ARYATRGALENFFRWRYMALHPGGMISRTILATTALIVGQTLFVHAGIDLDHIEALKKINEEVSAFF-RGESTP----D-SMVWMRRYGGTHTCATLNATLKALD-----VRRMVIGHTIQSKTINSACDGAVWRVDIGMSSGTEPQILEMWKNGVNVKKEAAMNQRLICIGDVHGDLWALQDFLEISGVYDEWIGGNTIVVQCGDILDRGVEELACYKLLCKLSQQAIHTDGKVILLVGNHEAMNS---------------MGL---FQYAINDLEHERKIGRWSSYEPGGLLATSLLAKVAIRVGRTVCVHAGLRPSHLGGIEGMNKQFRDWITLET---------GPIWMRDYSYPHTTRMIEETLLLLD-----CDRMIMGHTIQ--QINCVLHGRAWRIDVGASRGGTPE-IKIKYRY---------NQRIVSFGDVHGDITALRTFLITARVLDRWSGGDTICVQTGDVLDRGDDELACFRLLATLSRQAKESGGALLLLYGNHESLNA---------------AGL---FQYANPGGNAEFESTRWASFEPGGLLAENMLGLVACVVGRTVFVHAGLQAVHLNGISKLNMEARDWILKDCIGA----S-SPVWMRDYSQPNKNPYAKTMIGTLN-----VQRMVMGHTPQ---INAAMNGRAWRIDVGASQGGTPEVLEI-------------AERLVVIGDVHGDIDAFRSCLQMADLVDKWAGGETVVVQMGDIFDRGDDDLPIQEWVYKLAQEAGRANGALYSVMGNHEMLNA---------------MGD---HSMATRKAFVPFLALRLAAMRPGGPVA-RLMAAVSMKVGDNLFVHAGLLPEHIGGMERLNADTCAWM-LGKWQP----E-GPLWTRVYSTPDARAQLEEVLRLTG-----TKRMVVGHTPQAG-INSAADGQVWRVDTGMTAMGRPEALEIRGEEMTILTEYKS--MIPFIGNRVLD--AFAETLLAAGLVDNWAAGETVLVQAGDVFDRGDADLEVEEWLWTLQEQATESGGAVYHLLGNHEIMNA---------------MGD---HSTASPNSFKPFQDLRLAAMAPGGPVS-KMLASVAMKIGDTLLVHGGLRPVN-FDLESLNRWTHEWL-VGQWNR----D-SPVWTRFYSSPGAEADLQKVLDATG-----TVRMIVGHTPQAG-INSALGGRLWRTDTGMTAMGQPEALEIVDGVATIITAGGKAERIIAIGDVHGDVDALHECLKVANLVDNWIGGAAHLVQVGDILDRGMEERRCLQSLLDLKQKAADAGGAVHVLLGNHEVMNV---------------DLD---FRYVSPRENAWFGWERVYAFRPGGGAA-RCLSPIAIQIGDSVFVHGGLRLQHVYGLEKLNQETAAWL-YGSDDI----N-SPIWSRIYSVPSAELELEQVLEKLN-----AKRMVVGHTPQRG-INAFVGYEVWRTDTGMSQGGPIECLEILEDGVHVLTQAGIPKRIIALGDIHGDVRALATSLHMSHLIDNWIGKDSVLVQLGDVLDRGPNDYWCMRLLIKLQEQARASGGDVICLLGNHEVMNV---------------QLD---FRYVDPAAWAGWELERVNALRRGGTLS-KTLSPVCVVIGDTVFCHGGLMPEAVYGLQRLNDETSNWL-AGENP-----QFSPIWHRAFATANTLSAADCTMRLLH-----VSRMVIGHTPQEG-VNCLVGREIWRVDAGMSTGGPVECLEILAAKVNILSEDGVAARIIAIGDVHGGFNELHHALKISGCADRWTGGDTVVVQMGDFLDRGSDESRSIEMLRDLKVQAKDAGGDVITLLGNHEIMNA---------------DLD---FSYAP--DIYSFDSWRAQLMQRGGKLA-MLMSPVVVQIGDNVFVHGGLTRETIHGIDKLNQEVADWLRKDADPPKGGRTVSPLWERVYGMPIALETLDGMLESMD-----AKRMIVGHTPQYGGVGTEKEKEVWRIDTNLNDKGRVECLEILTDLVRVLSEDGRARRIIAIGDL--------ASLRLAGVIDKWIGGDTVVVQVGDVLDRGDEESAVYDLLRRLASSAARKGGAVHMLLGNHEVMNV---------------GWD---FRYCEMYEKVDGDCPERGGDRPGGPVARK-LGNTVLVIGENVFVHAGLHGRHVYGLERINREVRDWM-RGT---------DPDATKPACVT-NCAKL--TLEDIP-----AKRMIVGHTDN-G-INCACSGAVWRLDVGMSRVAAAEVLEIRGDTVTALRRGVRTDRVVAIGDVHGDLEALRSCLRLSGLVDAWVAAGATLVSCGDVLDRGDGDWDCLTYLADLKTRATDAGGDVHLVLGNHEVLNV---------------LGD---VRFASRGALVRC---RKRAFAPGSGEGARLLAPVARVCGDTLFCHGGLHAR--GGLDALNGDAARWL-GGAPSP----S-SPVWSRSYSHPAQCGDARSALDALG-----CARMVVGHTPQQG-INACCDDSVFRIDTGLSAYGPKEVLELRPGR---------EPRLVAFGDIHGDVFRCRQILQLANITDRWIAGSSIVVQLGDIADRGLHPHEIYDLFASLERQAMKAGGEFIFLVGNHELMNI---------------LGI---FYYVHPDVMSAFGGEYAAAFGPEGPYGLYILQPVTVVREGVVFAHAGITPEYAKGVEGINAELMNGF-RGESNS----S-SPLWSRAVLDE-NCSLLMESLRLLP-----VRVMVGGHTVQGGVMAVECNGSLVGADVGLSRFGYVAYVEFLLDD---------VHRIIAVGDVHGDADNFLKILRIANLIERWTSVRTTLVQVGDLIDRGEQDLEALNIAISLQEQTAQSGDEVVLLIGNHELLNI---------------QGH---YHYVNKHNYGGFLSKRAEGMKATGAFGKYIVDKAAHMDEGVLFIHAGIETSMNKDVEALNADVREALRQGILGS----S-GPLWTRKMIIE-ECSDVRAALKQLN-----ATRIVVGHTPQSGHIGQHCDGQVLAIDVGMSRWDKVAALELVFSK---------IHRIVAVGDVHGDAERFRQILEMSGVISRWTRLRTTLIQTGDLIDRGEEDLEVLEMAVSLFNEVRTNYDKVVLLMGNHELLNL---------------QGH---FHYVHSKSMGGFLTRRKRAFELDGTFGGFILETVAYAVADTLFVHAGIDEHVVDGIERLNREAKQAIRTKNLGS----T-GPLWSRKMFLD-RCADTKKALASLG-----VKRVVVGHTPQSGRVETFCGGSVIAIDVGMSRWGNIAALEITVTS---------IHRIIAVGDVHGDTENFRQILSMAGIVSMWTKLRSTLIQMGDLIDRGEDDLGVLEMAFSLFEQVKSNHDNIVLLLGNHELLNL---------------QEQ---FYYVHPETMGGFLSKRKRAFEPSGTFGRFLLDNVLYFDAETVFVHAGIDQRFAVGVEMLNKKTMQAIREKDLGT----S-GPLWTRKMITD-RCTGIQKMLSFIG-----AKRIVVGHTPQSGHVEVFCNDSVIAIDVGLSRWGNLAALELMVTS---------HSRLVLLPDLHGDARQAARALQLAGLISQWTGGDAMLVQLGDVVDRGHDSLALLGLLQRLGQAAEAAGGRVQAILGNHELMLV---------------HHD---YRYVSREELRAIGAAWQAGLAPSQPLGALVRRPLALLAKGVLVVHAGAFPWMRAGVDAWNAVALEALVHCDLGG----E-GAVWSRRYIQA-VCAEVAAVAERLG-----VQRVVVGHTVQGGRVSSRCGGQLLMVDVGLSRAGEMAVLTCSNGV---------PSRLVVLPDIHGDGPQALRALHLAGLISQWSGGDTVLVQLGDMVDRGPDSLALLTWLESLRGQARATGGDVVALLGNHELMNI---------------HHD---FRYVAPAEIVALAEAWREALAADAPLGSLVRQPLAALIDAVLAVHAGAFPWMLGGVAAWNAATAGALRFCELGE------GAVWSRHLAHGPVCLEVAAVVSRLR-----VERLLVGHTIQGGRVSSRCGGQLLLADVGISRAGEMAVLQCSSGKTDRQTEEEQFARIVAIPDIHGDLHHYRQSLRLAGVVDEWTAGSTHLVQTGDVVDRGQHSLLIMDMLANLTVRAKRVGGKVTALMGNHELMSL---------------MDD---TRYVHKDEILLLGTKWHRSFDPDAKQGRRLRRPLATVAGSSLFSHAGVRSRHLGGVDAMNEAAAAAI-QGKYDN----E-SPVWNRFYSREDVCDEVNRVLTAAR-----ANRMVIGHTVQGG-MRTKCGGKLHLIDVGMSSAGRGAAWVCEGGETELLEKEADARRLVALPDLHGDLDLARRSLILARVINAWSGGETILVQTGDVLDRGDASVALMRLLNKLARAAKDAGGEVVGLLGNHELMTL---------------QGD---LRYVSKRELVKLGKAWRDLFRAGADLGETLRFSMLHVAGESLFSHAGIRAHHL---EGVNGALRAASAGDGAFG----D-GPLWNRFWSTPRVCDELGAVLAKVG-----ARRMVIGHTIQRG-MATRCGGGLHLIDVGVSGKGRPAAWACEEGVVEVLDDGVE-------------MF---EALALAGVTRGWGAGRATCVQTGDLVDRGERSIEAVDEVERLTREANAVGDEFVSLLGNHELMTL---------------QGD---HRFASRDELTALGRSWRQTFAKGSTRGDVLREPWAAVRGRTAFSHAGLLPEHLFGVDELNARGAKLLAVDELLD----R-GPMWTRTISMG-ACALAAEVIRRLG-----VRRMVVGHTVTSGKIETRCDGLIHMIDVGMSKAGSPSVWMCTESESRVPLEN--RRKRLA------------VGRRLAGVVDSWGGGATTVVQTGDATDRGARSIETIDAIERLRVEAKEVGDEVVGLLGNHELMTL---------------QGD---YRFVAREELLALGRRWGKMFARGSERGEVVREPWAVVRGRTAFAHAGLLPEHLLGVDALNAEGKRLLAVECLVG----D-GPVWTREISTG-ACDAALEVTRRLG-----VRRLVVGHTVTSGRIETRCDGLIHMIDVGMSRLGSPSAWTCVESQGERVALE-----------------------------------------------------------MDLGVRALREGGT----------------------------TGD------------------WMRAFARGSARGDEVRSPVAVTRGETVFVHAGLTSRHLFGVDALNARARELFDVDVTGG----D-GPLWTREISMG-VCKEVEETLARLN-----VKRMVVGHTPTSGSIETRCEGMVHMIDVGMSSAGVPSVWMCTESEGERVALE--LKRIVAVADVHGDRRNLMQALENGRVLVEWVMEGTQVVQLGDLVDRGPLGLQCYRLMQDLY--VAEGANEVVRVLGNHEVLNL---------------LGMA--GRYVTDEDVAEFGGERRESWSPGGEIWTILKDELVHVYGGHRFVHGGVMPALTRSIDELNEQASRMIKNGALS-----ESSPLWSRVYALG-ACPPLLNVLRHYG-----VARMVVGHTPSDGRMKVRCGGRAILADVALSRWGHPAALEMTLVN---------LKRIVAVADVHGDRRNLMQALENGRVLVEWVMEGTQVVQLGDLVDRGPLGLQCYRLMQDLY--VAEGANEVVRVLGNHEVLNL---------------LGMA--GRYVTDEDVAEFGGERRESWSPGGEIWTILKDELVHVYGGTLFVHGGVMPALTRSIDELNEQATRMIRDGALS-----ESSPLWSRVYALG-ACPPLLNVLRHYG-----VARMVVGHTPSDGRMKVRCGGRAILADVALSRWGHPAALEMTLVN---------PSRLVAIGDLHGDLPKSLSVLRLAGLVPSWPAGPTLAVQLGDILNRSDDELRLLYLLHRLSLSAETRGGAFLPILGNHEVMNV---------------SGD---FRFATPQGFHDRAVCKLPAFLPGGFLASNQTSQRLIKV---LFVHSGLLMKNRSDLEEYIQETGRAGRDGRLSCHLFLDSTTFYKSEYAMSKICSLVKESTSRKV-----LTQLEIGHLQQSGEISFGCGGRYLEVDPVVMEAAKAELVKLVGKG---------PSRLVAIGDLHGDLPKSLSALRLVGLVPSWTAGPTLTVQLGDILDRGGDELRLLYLL-RLSLSAETRGGAFLPILGNHEVKNV---------------SSD---FRFATPQGFHDRAVNRGGGLDPSRLCACAGFAGAVLIVSRDFNLHQAFKFECAYAYTEENTKPGKYI------TKPRTNNSLIW--------KCDQVLS-----------NNLFGLGYAIQ--------ERRVERASVCVTT----------------------PSSVCAVGDLHGDLQHALAALALCGAVDSWVGGAMTVVQTGDVLDRGNNSLGVLRALWRLQAEAEAAGGELVLLLGNHELMNM---------------QGK---VHYVHKAELAAEGGAWKRRMQPTGDLGAALLRDAAAVRGGTLFVHAGVRLSVAFGVERLNEA-----------------------------------------------------VGHNIV--WVSSRCGGTLALLDVGMSSAGLPAACDVGEEGYHGAATRGPARRLVAVGDLHGDYEQTVSVLRLTRLIDHWIGEDALLVQLGDILDVGPDDILIVRLLMRLQQEAHAKGGDVIELLGNHELRNF---------------RGD---YKAVDKASLAASGGQRDVLLSNATDLGRY-LRKAVFHYGPFLFMHGGFSTATATSVEQFNSELTKALLNGTEDDVDDVA-NPILVRSILTV-KCNALSKVLDKKG-----IQSVVVGHVPHPRDFDGLCGGRLIDIDFGMSRWGHVAALEIEEATVQLIETSTAGRQIVVVGDLHGDLNQTLAILKITGLVDHWIGGDSFFVQLGDIFDVGPDDISIVKLLMKLEKEAQSVGGDVIELLGNHEIRNL---------------LGD---YSAVDPGSLAGSGGVRDRLLSNRTSVGMY-LRKAIFHHNEFLFMHGGLSTATATGIHEFNKDLRKALTNGTEGGGQEVV-NPILVRSILNV-RCKDLIKVLQNKG-----IKSVVVGHVPHHQDFKDLCGGHLIAIDFGLSRWGHVAALQIDDTTVQLLESTVRGRRIVAVGDLHGDLNQTLSILHLAGLVNHWIGKDTYFVQLGDILDVGPDDLMIVRLLMRLEKEAQAEGGDVIQILGNHEIRNL---------------LGD---FSAVDPVSLAQSGGKRRELLSNRTPLGIY-LRRAIFHHKEFLFMHGGLSTATGTGVEEFNKALRDTLINNTENEAKKVA-NPILVRSILNV-RCSELEKVLSKKG-----IKSVVVGHVPHTDDFSDLCGGRLIAIDFGLSRWGHVAALEWDDVSVQLMESTGKNQRIIAIGDLHGDIDRLRSTLRAANVLEAWRKGTDVVVQLGNVVGYGPDAPEMLQLLSGLKPQALASGGRLITLSGNQELLTL---------------SGV---LEYVHPRQLNLSAGYLRYLYGPGGRYGRMMAELAVAIVSDIVFVHGGLTAAYARGVNKLNAE---WY-EGAHDE----E-SPLWDHSVVRA-NCGPLSAGMAALD-----INLMVVGHTTMDGKVGTWCAGKLMTIDVAMSRYGGYEAFVSFLPMLVLGTAERVVEKLIAISDIEGNFEAFRRFLLSHKVIDNWIFGKGHLVCVGDFFDRGANVTECLWLIYDLEEKAKAAGGYVHFILGNHEIMNM---------------SND---YRYVSPKYMRNADLYYGNWFKSSTELG-RWLGNVVEKIGDMIFVHGGLAPDLNKTLIDINNAMRPFYFIQEFDA----N-GPLWNRSYVMANPESDVAESLRKFG-----GKRIIVGHTLV--HAKMLYGGKVIAIDTRHVDPNSTALFFEDGKL---------PKQIFVLSDIEGNFKSLFLLLRNYKIIDKWSFKDNHLVILGDCFDRGEEVMECLWLIYSLEERAQRDGGHVHFILGNHEIMNM---------------NGD---WRYIHPKYAITPSGSATALYDGNSELW-RWLRNIIEQIGDILFVHGGISEALLLSVTEINELARPYYTRANNS-----DESPFWYRGYYRAASEGQVDTILKKFD-----AKMIITGHTIV--KVTSFFNGKIINVDTNHAAGVSEALFIKGNNF---------PEKLIAISDIEGNFDAFCGFLQKNKIIDNWVFGKGHLVLNGDFVDRGQHVTPTLWLIYKLEEQALQQGGKIHYVLGNHEIMNF---------------QGN---HKYADAKYIKLAQIIYKILYSKKSEIG-RWLRNVVTKIGDYLFVHAGFSPEILLSLENINEITRKNWDKDLLG-----RKGPFWYRGLVKSYNAKDVQEILKTYQ-----AEKIVVGHSIV--AVSADYHGKVIRIDVKHGNE-QGLLVENGIEY---------IKKVVALSDVHGQFDVLITLLTNQKIIDNWAFGNGHMVMTGDIFDRGHQVNEVLWFMYKLDQQARDAGGMVHLLMGNHEQMVL---------------GGD---LRYVHKRYDVAAKLLYDKLYGADTEIG-QWLRNTIIKINDVLYMHGGISSEWILTLARANKLYRQHVDASKFFG----N-GPTWYRGYFSEETETELDTILNHFD-----VKRIVVGHTSQ--RILGLFNNKVIAVDTSIKKGGELLLLENKQLT---------IKKVVALSDVHGQYDILITLLRNQNIIDNWAFGDGHMVMTGDMFDRGHQVNEVLWFMYQLDQQAIEAGGKLHLLMGNHEQMVM---------------RGD---LRYVHERYQVAAKLLYDELYDKSSEIG-QWLRHTLVKINDTLFLHGGISGEWLLTLDVANDLYRKNIDRSKFFG----N-GPTWYRGYFKPGDEAELDKILSYFD-----VKHIVVGHTSQ--RVLGLYNNKVIAVDSSIKEGGELLLMEDNTLT---------AGKIVALSDVHGQFDVMINLLKAHKIIDHWAFGDGHMVMTGDMFDRGHQVNEVLWFLYELDKEAQAAGGRLHLLMGNHEQMVF---------------RGD---LRYINERYKTSAELLYDALYNKDTEIG-RWLRNTLVKINNLLFMHGGISPEWVLNISDANQLFRQHLDDKKFFT----N-GPTWYRGYFKDASEQEIDQILSYFK-----VDHIIVGHTSQ--RVLGLYHNKIIAIDSSIKNGGELLLIDKDKLT---------VSKIVALSDVHGQFDVMINLLKAHKIIDHWAFDDGHMVMTGDMFDRGHQVNEVLWFLYALDQEAQAAGGRLHLLMGNHEQMVF---------------RGD---LRYVNERYQVSADLLYDALYNKDTEIG-QWLRHSLVKIINILFMHGGISPEWVLHISEANQLFRQHLDDKKFFT----N-GPTWYRGYFKDEKESDIDSILSYFK-----VEHIVVGHTSQ--QVLGLYHNKIIAIDSSIKNGGELLLIDAGKLS---------PEKTFVLSDPHANWSCFASLLKAGKVIDNWIFGTNQLVIIGDVFDRGVDVLPIYWLIYKLEKEAEDAGGKVTFLIGNHETMVL---------------GND---LRYTKKKYTQLADTLYPELWQK-SELG-HWLKNSIQVVGDNLFVHAGLSKEFLYDIPTVNEIVSDGLFLTKFA-----TYGPIWYRGMVRSADRDDLRKILEKYN-----VNRIFVGHTIF--DITTFYHYKVIAVNVDNQENGRGVMIEKDGSM---------ADKVFVMSDPHGRLDCVISLLQGNHIIDKWSFGKNHLMIIGDIFDRGKDVPQIFWLFYKLEEEAAKAGGHVSFILGNHEPMVL---------------AND---LRYTKEKYKILAEKLYPRLFGPDTELG-RWLGNTMQMIGNDLYVHAGLGKDFYLSIPTVNEEMSKGLFMTKYG-----NSGPIWYRGLVRTDAKDSLEMIMDRYK-----AKHIIVGHTIF--DISTFYNGKVIGVNVDNKENGRAMLIENNQYF---------NGKIIAIGDIHGDIESLKLILRHSKLIGNWIGDNVLLVQNGDVFDRGIYGPIIYNFLFKLQKEAIKKNSRVILIMGNHEQLNL---------------CGY---FNYVNPKEIEMFFHNRYHSFVNPGEYHKRLIRPPMVKVNNIIFTHGGLNLLISLSINDINLKTRLQIENNCLS-----RDGVLWSDAMSRNVKCSELFQILDKYD-----AKYLVVGHTRQSHQIGSYCNNHYFLIDTGMSLFPYPNYLKIDDHK---------NGKIIAIGDIHGDIESLKLILRHSKLIDNWIGNNVLLVQNGDVFDRGIYGPIIYNFLFKLQKEAIKKNSRVILIMGNHEQLNL---------------CGY---FNYVNPKEIEMFFYNRYHSFVNPGEYHKRLIRPPMVKVNNIIFTHGGLNLLISFSINDINLKTRLQIENKCLS-----RDGVLWSDAISRSVKCSELFQILDKYD-----AKYLVVGHTRQSHQIGSYCNNHYFLIDTGMSLFPYPNYLKIDDHKPSHQIGSYCNGKIIAIGDLHGDIDSLKLILRHSELIDNWIGDNVLLVQNGDVFDRGIYGPIIYSFLFKLQKEAVKKNSRVILIMGNHEQLNL---------------CGS---FHYVNPMETKIFFDNRYYSFVSPGAYHKRLIRPPMVKVNNIIFTHGGLNSLISFSINDINLKTRLQIENNCLS-----RDGVLWSDVISRSVRCSELFHILDKYD-----AKYLVVGHTRQSHKIGSYCNNHYFLIDTGMSLFPYPSYLKIDDNK---------EGKIIAIGDIHGDIESLKLILRHANLINEWVAENVLLVQVGDVLDRGIYGPLIYDYLFKLQKEAPLKKSKVLLIMGNHEQLNL---------------CGY---FDYVNEKEVEVFFKKRLFHFVYSGEYFKKLIRPAIAKVNDILFVHAGISTQISLSLNTIRLKTRLQIENMCVS-----REGVLWHDHISRTAACSILSQIFNNYK-----AKHLVVGHTRQTHEISSYCNGGFFLIDTGMSLFPYPNYLVVQNGT---------EYDFYSIGDLHGDKDAFIRILLNESIIDKVIRNNVLTVITGDVLDPTYDDIDIILFIKNYNESGKSLNSKIILLLGNHEVNNL---------------CLK---FK-TPQSNIENY---RNDMFRKGETIYNYLIDPFVVNVNNIIFSHAGVLPFYSYGIDFINEEGKREIINNC-------EYGPTLNRYYSYVTICSSLYKSLGLLK-----SSRMVIGHTVQNKQVNSFCQDKLLLADTGISRWGVISYIQYFNDG---------EYDFYSIGDLHGDKDAFIRILLNESIIDKVIRNNVLTVITGDVLDPTYDDIDIILFIKNYNESGKSLNSKIILLLGNHEVNNL---------------CLK---FK-TPQSNIENY---RNDMFRKGGTIYNYLIDPFVVNVNNIIFSHAGVLPFYSYGIDFINEEGKKEIINNC-------EYGPTLNRYYSYVTVCSSLYKSLGLLK-----SNRMVIGHTVQNKQVNSFCQDKLLLADTGISKWGVISYIQYFNDG---------EYDFYSIGDLHGDKDAFIRILLNESIIDNVIRNNVLTVITGDVLDPTYDDIDIILFIKHYNESGKSLNSKIILLLGNHEVSNL---------------CLK---FK-NPQGNIEDY---RNDMFRKGQEIYNYLIDPFVVNVNNITFSHAGVLPFYSYGIDFINEEGKKELINNC-------EYGPTLNRYYSYVTVCSSLYKSLGLLK-----SNRMVIGHTVQNKQVNSYCQDKLLLADTGISKWGVISYIQHFNDG---------EHDLFSIGDLHGDMDAFLKILLNEKMIDNVIRENVLIVITGDVLDPSYDDINILFFIEEYNEKGKALNSKILMVLGNHEVKNM---------------CLE---FN-KVKKNVEKY---RNDMFPKNEVIYNILVNPFVLRVNEMVFSHAGVLPFYAYGIDYINKEGKNEIENNC-------DYGPTLNRYFSFVNVCSTLNKSLNLLS-----SRRMIVGHTVQNKKINSFCDDKLLLTDTGISKWGVVSYVQYFKDGKKINSFCDDRNGLRIVGDVHGDLDAFRHA----------VATDRFVIQLGDLVDYGPDSAGVLRLMLQVMHE-----KRGLFLIGNHDRKLGRAL------------MGK---RLRSTPHLEDTLAQ-LYRPENTDLHALLPVLEPAWMVMGQTVFVHGAFDPRM---LGRVTYLLSRALFGETDGPERTLN----WVN--------------------TIPAGYTIYCGHDQRNGCPLA--GGQAIFVDTGAGKGGHLAWLDLPPPF---------GRKLRVVGDVHGDLHAFRHA----------AATDRFVIQLGDLIDYGPDSAGTFRLMQQLMDE-----RRGLFILGNHDRKLARAL------------QGR---KMRRDPPLMETLAQ-FMAEENADHQRALADLAPPWVVIGQSVFVHGGFHIRM---LGTVTPLLSRALFGETDGPERRLN----WVD--------------------HIPAGYTVYCGHDRRDGRPWV--GGRAIFTDTGAGKGGHLAWIDLPPLL---------GRPIRVVGDVHGDLRAFEHA----------VATDRFVIQLGDLVDHGPDSAGTFRLMQRLLDD-----GRGLFILGNHDRKLARAL------------AGR---KMRQDAPLIQTMRQ-FQAPENEDRTRAWQDIAPPWIVLGRRIFVHGGFHSRM---LGTVTPLLSRALFGETDGPERRLN----WID--------------------HIPPGYTVYCGHDRRDGRPWI--GGTSVFTDTGAGKGGHLAWIDLPDDA---------EHGIRVVGDVHGDFNAFRHA----------TATDRFVIQLGDLVDHGPDSAGVMELMLELLEQ-----QRGLFILGNHDRKLGRAL------------EGR---RLRRDPPLEETLRQ-ISLPEYEGPERAYRAIDPTWLRIGRSLFVHGGFHTAM---LGEMSAPLSRALFGETDGPERRLT----WIN--------------------RIPEGMTVYVGHDRRDGRPWR--GGTAVFTDLGAGKGGHLAWIDLNEP----------GAKLRVVGDVHGDSTAFAAA----------CATERFIVQLGDLVDDGPDTPGALRLMFGRLDA-----GRGLFLLGNHDYKLARAL------------RGD---SVQVGEALAATI-----ASLDPAAARAVEEIGPAWLVAGRVVFVHGGFDPAM---ADKRDRLLARALYGQTMGPERVLD----WVH--------------------RIPEGVTVYCGHDQRNGQPLT--GGRAIMMDTGAGKGGHLSWLDIDLP----------GAKLRVVGDVHGDSTAFAAA----------CATERFIVQLGDLVDDGPDTPGALRLMFGRIDA-----GRGLFLLGNHDYKLARAL------------RGD---SVQVGEALAATI-----ASLDPAAARAVEEIGPAWLVAGRVVFVHGGFDPAM---ADKRDRLLARALYGQTMGPERVLD----WVH--------------------RIPEGVTVYCGHDQRNGQPLT--GGRAIMMDTGAGKGGHLSWLDIDLP-----------MATYVFSDIHGHVEPLKRALERIN-----PTESDVFYCLGDMIDRGPSSLDTIKVIRAL--------PNCTVLMGNHEQLALQALANIEAQFMWQINGGDATLAELKTLSEEE-------------YCELIAWLQPLYVQGKDFVLVHAGVKSNG---VPVPTASLEQYLNKQS-------ENDLLWIREDFWQH------------RTSDASYPIVICGHTPT--WVQS--DDDKWGIDTGTTGGGQVTILRLDDLQ----------MRVLAIGDIHSGLKALEQVLAKAK-----VTTEDKLIFLGDYVDGWSQATETINFLIDLQKT-----HNCVFIRGNHDEFCRSWLTERKDNPMWYEHGGEATVNSYAKLDKQT-------------KELHIDFFTDYYLDEDKRLFLHAGFTNLK--------------------GDFEYFSKTFYWDR--------TLWELVLSLDPQRLTHYSEIYIGHTPV--------AANVWNVDTGAAFKGPLSIIDIATKQ----------MRTLVVGDIHSGLKALDQVLQRAE-----VTTNDKLVFLGDYVDGWSEAAETVDFLIELDKT-----HNCVFLRGNHDELCSDWLVKREDNPMWLQHGGAASAESYKKASQST-------------IDRHINFFNNYHLDAENRLYLHAGFTNVK--------------------GEHEYFQKTFYWDR--------TLWELALSLNPKRLLHYKEIYIGHTPV--------GANVWNIDTGAAFKGPLSIVDVDTKD----------MRKLVIGDIHGGLKALRQLLDRVA-----PAQEDFFVFLGDYVDGWSEAAETVDYLIGFARE-----HRCLFLKGNHDELCEEWLNGQAERELWLRHGGAATKKSYQGVGAAT-------------RGQHAKFFRAYHLDSENRLFLHAGFTNQR--------------------GEHEYFEKNFYWDR--------TLWETALSLDPARLRHYREIYIGHTPV--------AANVWNVDTGAAFRGPLSAIDAGNKE----------MRTLVFGDIHGGLRALEQLIEKVG-----INPTDKLIFLGDYVDGWSESAQTVEYLIQLSKK-----YQCVFIQGNHDLWCGRWLNLGVSNPVWEEHGGKATIQSYIQSGLLA-------------SAEHKTFYQEYHNGEDNRLYIHAGFTSMH--------------------GEKEENRLDFCFDR--------TLWEMALTMDPKRLVHYHEIFIGHTPT--------GCNVWNIDTGAGFSGKLTCMDVATKE---------MARTFVIGDIHGALKALEQVIGKIK-----PKAADTLIFLGDYVDGWSQSAQVIDYLMQLEKR-----YKCIFIKGNHDAWCESWLMGSLPDPTWIFNGGQATVESYAGLSPEQ-------------KDVHIAFYNDYVIDTENRLFIHAGFTSMH--------------------GAMERYEASTRWDR--------TLWEMACTMDPKRLLLYHEIYIGHTPT--------GCNVWNVDTGAAFYGKLTAMDIATKK----------MRTLAIGDIHGCLSAFNLLLEVID-----PRPEDVIVTLGDYVDKGHQSKGVIDKLISLHKR-----GQLVALKGNHELMMLEARQSLEKEFDWLNNDGKSTIDSYAKLGLPARL---------EDPDAHWHFIEVDWWERDNHFFVHANIDPY--LP------------------FEEQPEDKLFWEKFIN---------------PKPHYSNKIMVCGHTSQRGEPVN--IGYAICIDTWACGDGWLTGLDIETGQ----------MRTLAISDIHGCSIALETLLETVH-----LTPKDTLITLGDYIDKGPDSKGVLDKLINLYKN-----YRLIPLKGNHEIKMLQARQSDPDECFWLEFGGRETLNSYSKLGRKKTL---------ANPEEHWNFIQVDYWQTDNHIFVHANLDPN--LS------------------LKRQSEYDLFWKKFNY---------------QAPHYSGKTMICGHTSQNGKPIN--LGHRICLDTWVCGDGWLTCLELESGK----------MRTLAVGDIHGCTTAFDQLLEAID-----LRPEDKLITLGDYVDKGPNSKGVLERLLFLYEN-----HQLIPLKGNHELMMLDAFQGKRKDNFWLLTEGKTTLESYPQTN-DSPL---------LNPDSHWDFLKLDWYETDNHIFVHANLDPH--LP------------------LHKQSNHNLFWQKLYP---------------HHGHYSGKIVVCGHTSQDGCPVN--MGHQICIDTWACGQGWLSCLDVDTGK----------MRTLAVGDIHGCATAFDKLLEAIH-----LRPQDRLITLGDYVDKGPNSKEVLERLLYLYEN-----HRLVPLKGNHELMMLDAFQGKKKDDFWVIAGGKTTLQSYPQIEEDNPL---------LNPDSHRDFIKLDWYETDNHIFVHANLDPH--LP------------------LHKQSNHDLFWQKLYP---------------RHGHYSGKIVVCGHTSQNGSPVN--MGHQICIDTWACGQGWLTCLDVDSGK----------MRTLAVGDIHGCAKAFDKLLETIH-----LRPEDKLITLGDYVDKGPDSKGVLERLLYLYEN-----HQLVPLKGNHELMMLEAYQNQNHENFWVTVGGKATLASYGDTDKKNPL---------ANPDAHWTFVQLDWYETDNHIFVHANLDPD--LP------------------VHKQSGHDLFWQKLYP---------------RQGHYSGKIVVCGHTSQDGCPVN--MGHQICIDTWACGKGWLTCFDVNTGE----------MRTLAIGDIHGCSKALDHLLEIVN-----PKPQDTLITLGDYVNKGKDSKGVIDRLISLHKQ-----GNLIPLKGNHEIIMLQARHNPLKQRLWLEKGGKATLKSYSE----GHL---------IKPESHWDFLGINSYETANHLFVHASLDPY--LP------------------LARQPEYKLFWEKFQY---------------PAAHSSGKTMICGHTSQSGKPVN--LGHAICIDTWAYGQGWLSCLDVETGK---------EGRRIFIGDVHGHYDGLMRLLETIA-----PGQGDQIFFLGDLIDRGPASSQVVEFVKN---------SAYPCILGNHELMMLSAFEHTLHLLSWLSSGGRETIAGYTSRDL---------------FLEHMEWMQPYFLDLGDIWLVHAGVEPT--LP------------------LAEQTTEEFCWIRSNFHRS------------DRPFFADKTIVTGHTIT--------GSGWMDIDTGAYHPGWLTGLDWTAQT---------GQRRICIGDVHGHYDTLMALLELVA-----PGTEDAVYFLGDLIDRGPKSADIIEFVRR---------SSYQSLLGNHEMMMLEAIVQQETFIAWYHSGGANTLQSY-NHRI---------------PAEHLQWLRPTHLDLGDVWLVHAGLSPH--LP------------------IEQQGAEQFCWVRSEFHSM------------TQPYFANKLIIVGHTIT--------GPGWLDIDTGVYHTGWLTAFDIDQRQ---------SERRIVIGDVHGHYDTLNLLLEAIA-----PNQDDQVYFLGDLIDRGPQSSQVVELVMK---------HRYHCLLGNHEYMLLETVINSHQLQGWLYGGGYSTLVSY-DHHI---------------PQEHINWMKPTYLDLGDVWLVHGGIDPN--IP------------------LQEQTAQQFCWVRDDFHGM------------KKPYFEDKLIIIGHTIT--------GAGWLDIDTGAYHPGWLSALDLSTET---------THRRIVIGDVHGHYDTLIALLDAIA-----PASDDPIYFLGDLVDRGPESAKVVDFVRE---------NKYRCLLGNHEQMLLDVLISSEMFQSWLHSGGYSTLLSY-KHNI---------------PQEHLDWLKPHYLDLGDVWLVHAGVDPK--LS------------------LEDQTEEQFCWIRDQFHST------------TKPYFPDKLIIVGHTIT--------GVGWLDIDTGAYHPGWLTGLELTNKI---------SQRRIVIGDVHGHYEGLITLLEAIA-----PGGDDQVYFLGDLIDRGPHSSYVIDLVRD---------NNYLCLLGNHEQMLLNILISVATTQAWLHSGGHATIASYPDQSI---------------PKEHLEWLRPTYIDLGDVWLTHAGLDPN--LP------------------LSEQTAEQFCWIREDFHSI------------PQPYFPDKLVIIGHTIT--------GQGWLDIDTGAYHPGWLTGLDITNNL---------EPRRIIIGDVHGSFQTLLRLLNRVA-----PDSEDEVYFLGDLIDRGQQSLEVVDFVIK---------NNYQCLLGNHEYMLLKALVSEKWFNGWIESGGAATLLSY-NNNI---------------PAEHINWFQPAYLDLGDIWLVHAGVQPE--YP------------------LEQQTNEQFCWIRNEFHAM------------TQPYFKDKLIITGHTLT--------GSGWLDIETGVYHPGWLTALDWTNQL---------------MSDIHGCVDEFERALEQVLPHL--AEPGSELLLLGDYVHGGPASFAVIDRIMELQSRWP---DKVVALRGNHEQMMLEPG------------MGD------------------DERSHAHSEREYRAWLRPLYHVEGHVIFVHAGIDERA----------------------------GDLWRWGTDETT------------IGRFEDGWAIVAGHVST--------GEAHYYIDGDVLVSGRIPILLVDTAE----------MLIYAMSDIHGEKEAFEDALSVVDF----SRPDTVLVLCGDYFDSRHEHPEFLTYMREFQESHE---GQVVALMGNHEAWLL---------------EHD---TPASDPVFLDDMEEAKEEPLLRD-EKTRRWLSPLYYETDSQIFVHAGIDEDA----------------------------GEYWKLGVEDWY------------TYGTAFEKDIVAGHVGT--------GESHFFIDGTTEESKFVPVLKYDTET----------MKTYAMGDIHGCAAAFCEQLSELGFFD--SRCEDVLVLLGDYVDRGPNSLGVIREAMRLERDCP---GRVVALLGNHEDDLLRWLTPIERLRMWRAASGGATLRSFLGPAAYAELEDARACARIRCHADEVRWLCWLFHETERQVFVHAGIDESL----------------------------GVSWGT-SARDT------------IRFGTFPKDVIAGHTPT--------GASHFYMDGATFLSGRIPVLVYDSRD----------MRRYAISDIHGCIEPLQAQFEELGFFD--TDCADELVLLGDYVDRGPDSLGVLHAVMALEQRAA---GRVTVLRGNHDEMFLEWLDPEYRFRSFRQMPNLATMRSFLTDEQLRQLDHGTACHAIRNYPEVISWMQRDYHETERQIFVHAGIDESA----------------------------GREWALGTPRET------------TSNAPFYKDVICGHTPT--------GPSHIYIDGMTTASGVLPLLVWNSET---------ALRVALLTDVEGNWQYVRNVVRQSSCLK--LRDDCMLVFGGDAGDKGDQTLQCYEQLVSLKKRYP---DRVVLLVGNRDVNKMRFTNRLKWMLEHTMGQGDFERRRDVTDEEVVES---YMDSVKEGGVLYEYLLHSLAFVAHQTLWVHGGIINGD-PDVDELNRQVQEWI-----------E-HPTWNEKYVLPDVPLEISSLLSESG-----IRRVVIGHTPH--------GEEVIMCDTSYSDARAASELVVQPSG---------SRRVALLTDVEGNWQYVRNVVRQSSCLQ--LRDDCMLVFGGDAGDKGDHTLKCYEQLVHLKKKHP---DRVVLLVGNRDVNKMRLTNRLIWMLEHTMGQGDFERRREVTDDDIAKS---YLDSVEEGGVLREYLLHSLAFVAHQTLFVHGGIIDGD-PDVDKLNSQVQEWI-----------D-HPTWSEKYVLPDVPEEIASLLSESG-----IRRVIIGHTPH--------GEDVVMCDTSYSDACAASEVVVGPSG---------SLRVALLTDVEGNWDYVRNVARQSSCLQ--LKDDCLLVFGGDAGDKGDHTLKCYEQLVRLKKRHP---ERVVLLVGNRDVNKMRLTNRLKWMLEHTMGQGDFERRREVTDDAVVKS---YMDSVEEGGVLRDYLLHSLAFVTHQTLFVHGGIINGD-PDVDKLNSQVREWI-----------E-HPTWNEKYVLPDVPEEIASLLSESG-----IRRVIIGHTPH--------GEDVIMCDTSYSDANAASELVVEPSG---------GLRVALLTDVEGNWEYVRNVVRQSACLK--LRDGCMLVFGGDAGDKGEHTLKCYEQLVDLKKRHP---DRVVLLVGNRDVNKMRLTNRLKWMLEHTMGQGDFERRREVSEEDVVKS---YVNSVEDGGVLREFLLHSLAFITHQTLFVHGGIINGD-PDVDKLNGQVQEWI-----------E-RPTWSIKYVLPDLPEEAASLLSESG-----IRRVIIGHTPH--------GEGVIMCDTSYSDASAASELTVEPSG---------SRHICFLTDVEGNWNYVRNFVRQSTCLR--LNDDCFLVFGGDAGDKGGETLKCYEQLVRLKKKHP---ERVVLLAGNRDVNKMRFTNRLKWILEHTMGQGDFERRRTISDDAVLQS---FMESVQEGGVLREYLELSLAFVAYNTLFVHGGLISGA-PDVDKLNREVRAWI-----------D-RPLWTPKYVLPGLPSDVVQRLSESG-----INRLIVGHTPH--------GAEVVMCDTSYSDMRAASEVVLDPNG---------GRPIGYVTDVEGNAEYFCRYVEESTVVC--EADGAVFVYGGDVCDKGNGDLRVIACLLAFKEAFP---ERVFLLVGNRDVNKLRFSARLRWMLDCTMGEGAFDRRRSITDAQVYAS---YVGAAAKGGVLHKYLLQQIAALVDGTLFVHGAVNDAN-LAVAALNEQMAQW------------DASPQWEDDYGP--PSARVLAYLAASG-----VTRVITGHTPH--------GITFVIADTSYSDMSAITAIAVSSGG---------

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GDxHG GDxVDRG GNHE HGG MVVGHT IDVG Motif 1 Motif 2

Supplemental Figure S1: Alignment of the phosphatase domain of SLP protein phosphatases from both Prokaryotes and Eukaryotes. Candidate SLP phosphatase sequences identified as detailed in Materials and Methods were aligned using MAFFT. The alignment was visualized in GeneDoc and manually edited to remove the extreme N- and C- terminal regions outside the protein phosphatase domain, plus poorly aligned regions, prior to phylogenetic tree inference. Two conserved bacterial-like phosphatase motifs (orange) were identified in addition to the known canonical PPP-family protein phosphatase motifs (blue). Of the two bacterial-like PPP-phosphatase motifs, Motif 1 represents a novel region of conservation. Motif 2 was previously reported (Andreeva and Kutuzov, 2004). The gene identifiers of each sequence used here are located in Supplemental Table S1.

Supplemental Figure S2

AlRLPHc :AlRLPHa :AtRLPHb :CarRLPHa :ThalRLPH :BraRLPH :AtRLPHa :CarRLPHb :AlRLPHb :CpaRLPH :CcRLPHa :CcRLPHb :CsRLPH :LuRLPH :MeRLPH :RcRLPH :VvRLPH :PperRLPH :PtRLPHa :PtRLPHc :PtRLPHb :CsatRLPHa :MdpRLPHa :GmRLPHa :PvulRLPH :GmRLPHb :GrRLPHa :GrRLPHb :AcRLPHa :AcRLPHb :MgRLPH :EgRLPH :BdRLPH :PvRLPH :SiRLPH :SbRLPH :ZmRLPH :OsRLPH :CsatRLPHb :PpaRLPH :SmRLPH :MdpRLPHb :MpRLPH :MpRLPHb :SrRLPH :BnRLPH :NgRLPH :F0SP41_PLA :D5SSG4_PLA :E8R2G2_ISO :GammataRLF :B0C4K2_ACA :B2J0C0_NOS :Q8YP31_NOS :D7E399_NOS :Q31LV8_SYN :Q5N017_SYN :C7QL34_CYA :B1WQZ5_CYA :B1X333_CYA :B0JSQ6_MIC :E0UA25_CYA :A8ZSZ1_DES :Q3A7H2_PEL :A7HLU4_FER :H9UCV4_FER :C5CDU8_KOS :D0MK25_RHO :D5H4I3_SAL :Q2S6K7_SAL :B8DK70_DES :E1YER6_9DE :I2Q722_9DE :G7Q752_9DE :E1K2K4_DES :H2J819_MAR :A9BIC6_PET :E3I2B3_RHO :G8API0_AZO :D3NZT3_AZO :G7ZAB6_AZO :H5YEZ7_9BR :E8L7W5_9RH :F2IW59_POL :E0TGJ0_PAR :Q11UR6_CYT :B7IWU6_BAC :B7HV78_BAC :C6GXU9_STR :E8UQ78_STR :D3QFL2_STA :B9DJA7_STA :Q3M5P0_ANA :Q8YZT4_NOS :F4B184_KRO :E4NEL1_KIT :F8JTJ0_STR :G8WZV1_STR :F2RD99_STR :E4N448_KIT :

* 20 * 40 * 60 * 80 * 100 * 120 * 140 * 160 * 180 * 200 * 220 *RTVICVGDIHGYISKLNNLWLNPQSAIDPSEFSSALVIFLGDYCDRGPETGKVIDFLISLPEKHPDQTHVFLAGNHDFAFSGFLG----EGWYRGSVKGMAYKGSIYDLESVKLFVGLPLDDYNNV--NH----------------------------LKAITAGL----KALKLLGVEWGVVEKEAAGKLAVAETHH-TLRIT-------------------------------RTVLCVGDIHGYISKLNNLWLNLQSAIDPSEFSSALVIFLGDYCDRGPETGKVIDFLISLPEKHPDQTHVFLAGNHDFAFSGFLG----EGWYRGSVKGMAYKGSIYDAGSTFESYGVPHGLMKAVPESHKKFLTNMVWVHEEDDVCIDTEEGLKHCKLIAVHAGLNNVEEQLKLLRAK--KIQHLSGRKTVVVSGHH-KLHIRLIIDEGGGFPPVAAIVLPSKKIIRDTDNLSSRTVICVGDIHGYISKLNNLWLNLQSAIDPSDFSSALVIFLGDYCDRGPETRKVIDFLISLPEKHPDQTHVFLAGNHDFAFSGFLG----EGWYTGSVKGMAYKGSIYDAGSTFESYGVPHGLMKAVPESHKKFLTNMVWVHEEDDVCIETEEGLKHCKLIAVHAGLNNVEEQLKLLRAK--KIQHLSGRKTVVVSGHH-KLHIRLIIDEGGGFPPVAAIVLPSKKIIRDTDNLSSRTVICVGDIHGYISKLSNLWLNLQSAVDPSDFNTALVIFLGDYCDRGPETRKVIDFLISLPEKHPDQTHVFLAGNHDFAFSGFLG----EGWYRGSVKGMPYKGSIYDAGSTFESYGVPHGLMKAVPESHKNFLTNMVWVHEEDDVCIETEDGLKHCKLIAVHAGLDNVEEQLKLLRAK--KVQHLSGRKTVVVSGHH-KLHIRLIIDEGGGYPPVAAIVLPSKKIIRDTDNLSSRTVICVGDIHGYISKLNNLWSNLQSSLNPSDFSSALVIFLGDYCDRGPETRKVIDFLISLPEKHPDQTHVFLAGNHDFAFAGFLG----EGWYRGSVKGMAYKGSIYDAGSTFESYGVPHGLMKAVPESHKKFLTNMVWVHEEEDVCIETEEGLKHCKLIAVHAGLNGIDEQLKLLRVK--KIQYLSGRKTIVISGHH-KLHIRLIIDEGGGYPPIAAIVLPSQKIIRDTDNVSSRTVICVGDIHGYITKLTNLWLNLQSALDPSQFTSALVIFLGDYCDRGPETRKVIDFLISLPEKHPEQTHVFLAGNHDFAFAAFLG----EGWYKGSVKGMAYKGSIYDAGTTFESYGVPHGLMKAVPESHKKFLTNMVWVHEEDDVCVETEEGVKRCKLIAVHAGLDSVEEQLKLLRAK--KVPYLSGRRTVLVSGHH-KLHMRLIIDEGGGYPPVAAIVLPSKMIIRDTDNVSSRTVICVGDIHGNISKLNKLWLNLQSDIQNSDFSSALVIFLGDYCDRGPETRKVIDFLISLPEKHPDQTHVFLAGNHDFAFAGFLG----EGWYKGSAYGVLYNGSIYDAASTFESYGVPHGLIKAVPESHKKFLTNMVWVHKEDDVCIETEEGLTHCKLIAVHAGLNNVEEQLKLLRDK--RIQPLTGRKTIVVSGHH-KLHIRLIIDEGGGYTPLAAIVLPSKKIIRDTDNFSNRTVICVGDIHGNISMLSKLWLNLQSALK-SDFSSALVIFLGDYCDRGPETRKVIDFLISLPEKHPNQTHVFLAGNHDFAFAGFLG----EGWYKGSAYGVVYNGSIYDAASTFESYGVPHGLMYAVPESHKNFLTNMVWVHEEDDVCIETEEGLKHCKLIAVHAGLNNVEEQLELLRAK--RIQPLVGRKTIVVSGHH-KLYIRLIIDEGGGYAPLAAIALPSKKIIRDTDDISNRTVICVGDIHGNISLLNKLWLNLQSDIEQSDFNSALVIFLGDYCDRGPETKKVIDFLISLPEKHPEQTPCLSCRKPRLCFCWVLG----EGWYKGSAYGVLYNGSIYDAASTFESYGVPHGLINAVSESHKKFLTNMVWVHEEEDVCIETEKGLKHCKLIAVHAGLNNVEEQLKLLRAK--RIQHLTGRKTLIVSGHH-KLHIRLIIDEGGGYAPLAAIVLPSKKIIRDTDNFSNRTVCCIGDIHGYFTKLKNLWSNLESIIDPPDFQSALVIFLGDYCDRGPDTRRVIDFLLSLPARYPNQTHVYLSGNHDLAFAAFVG----EGWYKGTVKGTDYKGSIYDAAPTFESYNVPHGLVKAVPDDHKKFLADMVWVHEEDDVCIETDEGIKHCRLIAVHGGLVKVEEQLEFLRAR--KVEALSGRKTIVVSGHH-ELHIRLIIDEGGGLEPVAAIVLPSMKVIRDTDNIAKRRVCCIGDVHGYISKLQNLWKNLETHIGPSDFNSAIIIFLGDYCDRGPNTREVIDFLISLPTKYPNQKHVFLSGNHDLGFAAFVG----EGWFKGAAKGTEYKGSIYDAAPTFESYGVAHGLVKAVPDHHKKFLADMLWVHEEDEVCVETNDGIKHCKLIAVHAGLKKVEEQLELLKAK--KVEALSGRKTIVVSGHH-KLHIRLIIDENGGLEPVAAIVLPSMKIVRDINNLV-RRVCCIGDVHGYISKLQNLWKNLETHIGPSDFNSAIIIFLGDYCDRGPNTREVIDFLISLPTKYPNQKHVFLSGNHDLGFAAFVG----EGWFKGAAKGTEYKGSIYDAAPTFESYGVAHGLVKAVPDHHKKFLADMLWVHEEDEVCVETNDGIKHCKLIAVHAGLKKVGEQLELLKAK--KVEALSGRK--------------VII----------------------------RRVCCIGDVHGYISKLQNLWKNLETHIGPSDFNSAIIIFLGDYCDRGPNTREVIDFLISLPTKYPNQKHVFLSGNHDLGFAAFVG----EGWFKGAAKGTEYKGSIYDAAPTFESYGVAHGLVKAVPDHHKKFLADMLWVHEEDEVCVETNDGIKHCKLIAVHAGLKKVGEQLELLKAK--KVEALSGRK--------------VII----------------------------RTVICVGDIHGYITKLQNLWTNLEALID--DFPTALVIFLGDYCDRGPDTKKVIDFLITLPSRYPNQTHVFLAGNHDLAFSAFLG----EGWYEGVAKGTEYQGSIYDAAPTFESYGVPHGLMKAVPESHREFLANMVWVHEEEAVCVEKEGEIKHCKLIAVHAGLKDVQEQLKLLKAK--KIEALSGRKTVVVSGHH-KLHIRLIIDEGGGLAPVAALVLPSMKLVRDTDSLLSRVVICIGDIHGYLAKLQNLWSNLQSVINPEEFSSALVIFLGDYCDRGPDTKKVIDFLLNLPSAYPNQKHVFLSGNHDLAFAAFLG----EGWYKGATKGTEYKGSIYDAGPTFESYGVPHGLMKVVPDEHKRFLADLVWVHEEENVCIESEEGIKHCKLIAVHAGLKNVEEQLKFLKAK--KVEALSGRKTIVVSGHH-KLHIRLIIDEGGGLEPVAAIVLPSMKLVRDTDDLTKRVVICIGDIHGYFSKLQKLWSNLEAIVNPQDFNSALVIFLGDYCDRGPDTKKVLDFLIKLPSFYPNQKHVFLSGNHDLAFAAFLG----EGWYKGVAKGTEYKGSIYDAGPTFESYGVPHGLIKVVPDEHKKFLVDMVWIHEEEDVCIENEEGMKHCKLIAVHAGLKNVEEQLAFLKVK--KIEALSGRKTIVVSGHH-KLHIRLIIDEGGGLEPVAAILLPSMKLVRDTDNFNK-----------------------------------------------------------------------------------------------VTKGTEYQGSIYDARLTFESYGVPHGLVKAVPDEHKKFLADMVWVHEEDDVCIQTEEGIKHCKLIAVHAGLEAVDEQLKTLKAK--KVGPLSGRATIVVSGHH-KLHIRLIIDEGGGLEPVAAVVLPSMQVVRDTDKLAKRVVCCIGDTHGFYTKLQNLWSNLQTTIDPSDFNTALIIFLGDYCDRGPDTKKVLDFLISLPSKYPNQRHVFLSGNHDLAFAAFVG----EGWFKGAAKNTQYKGSIYDAEPTFASYGVPHGLVKAVPDEHKKFLADMVWVHEEDDVCVETEDGIKHCKLIAVHAGLKDVKQQLEFLRAR--RIEALSDRQTVVVSGHH-KLHIRLIIDEGGGKEPVAAVVLPTMKIVRNTDVLANRLVICIGDIHGHITKLQNLWSNLETQFDPQHFNAATIIFLGDYCDRGPDTKKVLDFLIDLPSRYPNQKHVFLSGNHDFAFAAFVG----EGWYKGTIKGTECKGSIYDAGPTFASYGVPHGLLKAVPDDHKKFLADTVWVHEEDDVCIEDEEGIRHCKLIAAHAGLKNVGEQLRFLKAK--KIEALSGRKTIVVSGHH-KLHIRLIIDESGGFEPLAAIALPSMKLVRDTDNLTKRLVICIGDIHGYITKLQNLWSNLETQFDPQHFNAATIIFLGDYCDRGPDTKKVLDFLIDLPSRYPNQKHVFLSGNHDFAFAAFVG----EGWYKGTSKGIEYKGSIYDAGPTFTSYGVPHGLLKAVPDDHKKFLADTVWVHEEDDVCIEDEEGIRHCKLIAAHAGLKNVGEQLRFLKAK-----------IIVVSGHH-KLHIRLIIDEGGGFEPVAAIALPSMKLVRDTDNLTKRLVICIGDIHGHITKLQNLWSNLETQFDPQHFNAATIIFLGDYCDRGPDTKKVLDFLIDLPSRYPNQKHVFLSGNHDFAFAAFVG----EGWYKGTIKGTECKGSIYDAGPTFASYGVPHGLLKAVPDDHKKFLADTVWVHEEDDVCIEDEEGIRHCKLIAAHAGLKNVGEQLRFLKAK--KIEALSGRK-------------LLIFLSETFYPPFSPAFFSGKGLGC-------RVVCCIGDVHGYITKLQNLWSNLESSIHPSDFNSALIIFLGDYCDRGSNTREVIDFLVNLPSKYPNQKHVFLAGNHDFAFAAFLG----EGWFRGLAKGTDYQGSIYDAGPTFESYGVPHGLVKAVPDEHKKFLSNMAWVHEEDDVCLDTEDGIKHYKLIAVHAGLKDVQEQLNSLKAK--KIECLSGRRTMVVSGHH-KLHIRLIIDEGGGLQPVAAVVLPPMKIVRDTDNMKQ---------------ISNPPSTHQISPPPSSFSSAITATA------AXDTKKVIDFLVSLPSRYPNQKHVFLTGNHDLAFAAFVG----EGWFKGXAKGTEYKGSIYDAGPTFESYGVPHGLVKAVPDEHKKFLADMVWVHEEDDVCIETADGIKHXRLIAVHAGLKDVKQQLAFLRAR--KIQALSGRKTVVVSGHH-KLNIRLIIDEGGGMAPVAAVVLPSVKIVRDTDALTNRAVICVGDIHGFITKLQSLWKNLEGSLDRSEFETATLIFLGDYCDRGPATRQVIDFLISLPSRYPRQKHVFLCGNHDLAFAAFLR----EGWFKGTVKGTEYQGSIYDAGPTFESYGVPHGLVKAVPDDHKKFLADLVWVHEEDDVFVNTDDGVKCCKLIAVHAGLKDVKEQLKLLKAR--KVEALSGRKAIVVSGHH-KLHVRLIIDEGGGYKPVAAIILPSMKIIRDTDELAKRVVICVGDIHGFVTKLKNLWSNLERSIDRSEFETATVIFLGDYCDRGPDTRHVIDFLVALPSRYPRQKHVFLSGNHDLAFAAFLH----EGWFNGTVKKTEYQGSIYDAGPTFESYGVPHGLVKAVPDEHKKFLADLVWVHEEDDVFINTEDGGKCCKLIAVHAGL-DVNEQLKLLKAR--KVEALSGRRTIIVSGHH-KLHTRLIIDEGGGFKPMAAIVLPSQKVIRDTDVLAKRLVICMGDIHGFITKLQILWSNLEASLDRSEFETATLIFLGDYCDRGPGTRHLIEFLVSLPSRY------LLGG---------------------TVKGTEYQGSIYDAGPTFESYGVLHALVKAVPDDHKKFLADLVWVHEEDDVFVNTDDGVKCCKLIAVHAGLKDLKEQLKLLKAR--KVEALSGRKQKHLIRHH-KLHVRLIIDEGGGYKPVAAIILPSMKIIRDTDVLAKRTVICVGDIHGYVTKLLNLWSNLQSQIDPDSFNTATVIFLGDYCDRGPDTRKVIDFLITLPKRYSNQKHVFLSGNHDFAFGGFVG----EGWYKGAAKGIDYKGSIYDAAPTFESYGVAHGLMKAVPEAHKKFLADMVWVHEEDDVCIETQEGVKHCKLIAVHAGLKNVREQLEFLKAK--KVTDLSGRKTILVSGHH-KLHIRLIIDEGGGLEPVAAIVLPSMKIVRDTDNFS-RTVICLGDIHGYLTKLLNLWSNLQSQIDPDSFNTATIIFLGDYCDRGPDTRKVIDFLISLPKRYPNQKHVFLSGNHEFAFARFIG----EGWYKGVAQGIDCKGSIFDAAPTFGSYGVSHGLMKVVPEDHKKFLADVVWVHEEDDVCIETQEGVKHCKLIAVHAGLKNVREQLEFLKAK--QVTGLSGRKTIVVSGHH-KLHIRLIIDEGGGLEPLAAIVLPSMKIVRDTDNLS-RVVCCIGDLHGYISKLQNLWSNLESEIDPVSFQSALIIFLGDYCDRGPDTHKVLDFLISLPSKYPNQNHVFICGNHDFAFSAFLR----EGWYKDHAKGTEYKGSIYDAGTTFESYGVLHGLVKAVPDEHKKFLANLVWVHEEDNVSIQTSEGKRNYKLIAVHAGLKGVEEQLKLLKGK--KVAALSGRATVVVSGHH-KLHIRLVIDQGGGLEPIAAIVLPSLKIIRDTDAKVARVVCCIGDLHGYISKLQNLWSNLESEIDPVSFQSALIIFLGDYCDRGPDTHKVLDFLISLPSKYPNQNHVFICGNHDFAFSAFLR----EGWYKDHAKGTEYKGSIYDAGTTFESYGVLHGLVKAVPDEHKKFLANLVWVHEEDNVSIQTSEGKRNYKLIAVHAGLKGVEEQLKLLKGK--KVAALSGRATVVVSGHH-KLHIRLVIDQGGGLEPIAAIVLPSLKIIRDTDAKVARLVICVGDIHGYITKLRNLWTNLETAVGPSDFRSALVVFLGDYCDRGPRTDEVIDFLISLPSKYPDQSHVFLCGNHDLAFAAFLG----EGWYKGHAKNTEYKGSIYDAGPTFEAYGVPHGLMKAVPEEHKKFLRDLVWVHEEDDVSIEMKEGLQKCKMIAVHAGLKGVEEQLNYLKNK--KVEPLSGRKTIVVSGHH-KVHVRLIIDRGGGLEPVAAIVLPSKKMVLDTDEFATRTVVCVGDVHGHFTKLRALWANLESSIPPHAFRAALVIFLGDYCDRGPDTRRVIDFFLSLPSAYPGQTHVFLAGNHDFAFAAFVG----EGWYRGEAKGTEYKGSIFDAAPTFESYGVAHGLIKAVPEEHKKFLANMVLVHEEDDVCITTPEGTKHCRLIAVHAGLKDVGEQLRSLKAK--KIEAIAGRKTIVVSGHH-KLHIRLIIDEGGGYPPVAAVVLPSLKIIRDTDILPTRTVICVGDVHGFISKLESLWANLQSALPADAFATALVIFLGDYCDRGPHTRRVLDFLLALPARHPAQRHVFLCGNHDLAFAAFVG----EGWFHGPKKGLPYKGSIYDAQPTFESYGVAHGLTKAVPEEHKRFLHDLVWIHEGENVPIDTDEGQIVCKLIAVHAGLIDLNEQLRVLRTR--KVQMLSGRQTVIVSGHH-KLHIRFIIDEGGGYEPIAAVVFPSKQLIRSTEGTAPRTVICVGDVHGHITKLESLWSNLQSALPAGAFATALVIFLGDYNDRGPHTRGVLDFLLALPRRHPAQRLVFLCGNHDLAFAAFVG----EGWFRGPKKGLPYRGSIYDAQPTFESYGVAHGLAMAMPEEHKRFLRDLVWIHEEENVPIDTDEGQIICNLIAVHAGLIDLNEQLRVLRTR--KVPMLSGRQTIVVSGHH-QLHIRFIIDEGGGYEPIAAIVFPSKALIRSTEGTTSRTVICVGDVHGYIAKLESLWSNLQSALPADAFATALVIFLGDYNDRGPHTREVLDFLLALPGRHPAQRHVFLCGNHDLAFAAFVG----EGWFRGPKKGLPYRGSIYDAQPTFESYGVAHGLAKAVPEDHKMFLHDLVWIHEEENVPIDTDEGQIICNLIAVHAGLIDLNEQLRVLRTR--KVPMLSGRQTIVVSGHH-QLHIRFIIDEGGGYEPIAAIVFPSKTLIRSTEGAASRTVICVGDVHGYVTKLESLWSNLEAALPADAFATALVIFLGDYNDRGPDTRRVLDFLLELPTRHPGQRHVFLCGNHDLAFAAFVG----EGWFRGPKKGLPYKGSIYDAQPTFESYGVAHGLAKAVPEEHKRFLHDLVWIHEEENVPIDTDEGQIICNLIAVHAGLIDLNEQLRVLRTR--KVQMLSGRQTIIVSGHH-KLHIRFIIDEGGGYAPIAAIVFPSKTLIRSSEAH--RTVICVGDVHGYITKLESLWSNLQAALPADAFATALVIFLGDYNDRGPHTRRVLDFLLALPTRYPAQRHVFLCGNHDLAFAAFVG----EGWFRGPKKGLPYKGSIYDAQPTFESYGVAHGLAKAVPEEHKRFLHDLVWIHEEENVPVDMDGGQIICNLIAVHAGLIDLNEQLRVLRTR--KVQMLSGRQTIIVSGHH-KLHIRFIIDEGGGYEPIAAIVFPSKTLIRSTEEAGTRVVICVGDVHGYISKLESLWANLQSALPPDAFATALVVFLGDYCDRGPSTREVIDFLLALPSRHPAQRHAFLCGNHDLAFAAFVG----EGWYRGPKRGSSYMGSIYDARPTFESYGVAHGLVKAVPEEHKKFLRELVWIHEEENVPIDTNEGQIICKLIAVHAGLIDLNEQFRILRTK--KVAMLSGRQTIVVSGHH-KLHIRFVIDEGGGYAPIAAIVFPSKELIRSTEGTSSGVLCCIGDIHGYFTKLQNLWRNLESAIGASDFASATVIFLGDYCDRGPNSREVIQFLVSLPFRYPDQKHVFLAGNHEFGLAGFLG----EGWYKG-AYGIEFMGSVYDAAPTFESYGVPHGLMNAVPDEHKKFLSNLVWVHEEDDVCLETKDGIKTYRLIAVHAGLKDIEEQLKFLKAK--KIMGLSGRKTILVSGHH-RLHMRFIIDEGGSAPPLAAIILPSIKIVRDTDLL--RMTICVGDIHGHLDRLKALWRNLELKLGSEVFASSTVIFLGDYNDRGPDTKGVLEFLVGLPERYPKQRHVFLCGNHDFAFAAFLG----EGWWSGTTRNEPYKGSIYDARPTFESYGVSHGLIAAVPDNHKEFLRNLAWVHEQEGEETEDPE-TSYTKLIAVHGGLNSLDNQMQMLRTK--RIEPLAGRKVLLVSGHH-KLHFRLIIDESGGFDPIAAMILPAREIVRDTDNFSERPTVCIGDVHGHLIRLRALWRNLEAGLGA-LFASATVIFLGDYCDRGPDTAGVLDFLVALPASYPSQKHVFLCGNHDFGMSAFLG----EGWWSGVKKNMEYRGSIFDSEPTFSSYGVEHGLLGAVPEDHKAFLRKLVWIYEQ-------DGSESCGKLVAVHAGLRPLEEQLRVLREK--RHENMLGRSILSLSGHH-SLHMRLIIDESGGQDPLAAVVLPGRQIVRDTDSIGHSSRIS--------GPISNPPSTHQISPPPSSFSSGITAFPPDIRIRSTSSSPITTTWPSPPSWASCSR---------------------KGGLREATKGTEYKRSIYNDGPTFESYGVPHGLVKAXPDKHKXFLSDMVWVHEEDNVCIETADRIKHCRLIXVHAGLKDVKQQLAFLKAK--KIEAIFG--VVVLIVTD-ETNYKLTIDEGGGMAPVAAVVLPSMKIVLDTDALTNRATVLVGDVHGHRAKLVSLFENLEREIGAERLSTSRVVFLGDLVDRGPETSGVLDFIASLPAVHPSMEVRILGGNHDLGMATFCS----PLWVDA------GTRNAFDSEATFASFGVDPGLLSSLPESHAVLLSSLEFVVELDDV--EDDMHPEVNKLIAVHAGLRPIPEQLEALRER--WIEALQGRTVLVASGHH-ILKTWLVVDECAGLDQLAAVVLPERAVVKSH---------------------------LKLELGTERFETSTVIFLGDLCDRGPETSGVFNFLSSLKDKHPRQDVRHLAGNHDFAFATFLG----PLWEDS------DGINAFDSHTTFTSYSAAPGLLKKVPVEHKKILESLEFVVEVEDA--EEHG----KKLVAVHAGLCPFDVQMTALRQR--WVEALQGRAVIIASGHH-ILEMRIIIDGCGGHRRLAAVILPERKVVRSSS----DMCLCIGDLHGRYLRLQQLWTNASVYFGP-WMAGVDVVFLGDLCDRGSDTRQVVDFLLWLQRTRPNTTHI-IAGNHDFGLSSFLR-------------------SVFEAAATFESYGCKFPLLAAMPAAHLSFFRDLPWLVDL---------RFSFGRVICLHAGLKDMDPQMQLARER--FLEVIAGRGVIEVSGHF-FLDVRCIVDEGGGRDALAALVLPSRHILRHNEHVQTKRVVCIGDLHGNIDKITNLWANLQDQLGKEGLKKATVIFLGDYCDRGPDTKGVISWLIDLKKKRDASGTYFLCGNHDFSMAAYLG----PGYTSG--------CSIYNADSTFSSYGVKWGFIAAVPEAHKLFLKSLDWVCDI-------EIGFGPGRLIACHAGLGSLKDQLEGLKKR--RYFSFSARDAYLVSGHH-YREVRIICDRSGGYALLEAVILPSQPLNFVNDVRENKYIVAIGDLHGHLSALKLLMLKLEEALGNDLHQKYHLVFLGDYVDRGPKIKETIEYLIQLEKSRKPGTTHFLMGNHDFAMAMFLGLFDDELWKGN---------FTYSSFNTFYSYCTKDGLLRRMPESHKQFFRNMPWMLYN-------------EKNIFVHGGFSSLKEQMLPLMRRVPRIKPISERNRRIVSGHMQRVKVRALVDVSGGLTELACVVLPSCKVITTQPPVAAGPIAVVGDLHGQVDKLGVVLDAIQDA---PQFDDRWVVFVGDFVDRGPDTKACLDMVLEFMDYHPK--TTAVAGNHDFAMCSSLG----GRWL-----------DHYDSQATFRSYGVEFGLAAAMPLQHKKFLASLPWVVEH-------------PYTIIVHAGMTPTDMQLKILRQRLNRPQWLCEKKKTVVSGHVWRVTYRILCDTTGGLENLSAVLLPELQVVDSGNSSFPGPVAVIGDVHGQLDLLNFILSQLQQL---PNYDELWIVLIGDLVDRGPDPAGVIQRIVELREAHRR--TTVVFGNHELAMLGALG----PRWV-----------QFYDSEPTFRSYGVEPGLARAIPPEHREFLTTMPWVVEH-------------PENIFVHAGLQPTEMQLRILHAKLVRPPWLCDKARRIISGHVPEVVIRILTDTTGGLRELSCVILPECRILQSRGGVDRYPILAIGDLHGQSEEFDRLLDRVDRL---AEWPDCAVVFLGDFVDRGPDSRKVIDRVLEILERPPG--GAAVMGNHDLALVHAARLRSPHYWLER-------YLSVYDAATTVRSYVGRTWLRAAMPETHRRFLAELPWVVEA-------------SGHLFLHCGLADALAQVEAMKRRWDRPDYWLGADKIQVTGHCQRPDARIRIDTSGGYGPLTACLLPTDPPHFISSWDDLYPVVAIGDLHGRVEWLDKLVAKLRRR---PEWPHAKLVFLGDLVDRHFEVRALVSRVLELIAEKPG--STCVAGNHDLALVRAAG---LVEWAQR-------YGRNYDHQWTFRSYLGRTPLKAAMPAEHRAFLAGLPWVAEA-------------EGHVFLHNGLCPAAVQLECLHRKWDRPEYWLGADKVQVSGHVHAPDARIRIDTSGGVTPLTACVLPNAEPVFVFSNE--LRRFVIGDIHGHYQGLLDLVSLLEIG------ESDQIYFLGDLIDRGPDSSKVVDFVREQ-----S--YTCLLGNHEQLMVAALANLSPQMWL-Q---------A--GGRETLQSYSSK-----QHLWEHLSWIKTLPNHLDL-------------GDYWLVHAGILPLERQTAQEFC-WIRREFHNMP-RMIITGHTMFSGVWLGIDTGAYHPWLTALELSSSTVYQINVHSNVPRRIVIGDVHGHYEGLMTLLEAIAPT------SDDQIYFLGDLIDRGPHSSQVVNFVKRH-----N--YPCLLGNHEQMLLNILTNERTQAWL-Y---------S--GGQATVASYHEA-----SIPDDHLDWFKSLPTYLDL-------------GDIWLTHAGVKLVTEQTADQLC-WIREEFHSIE-KLIIIGHTILPGVWLDIDTGAYHPWLTGLDVTNNLVYQVNIFKNYQRRIVIGDVHGHYEGLVTLLAAIAPG------GDDQVYFLGDLIDRGPHSSYVIDLVRDN-----N--YFCLLGNHEQMLLNILSGDISQAWL-H---------S--GGHATIASYPDQ-----SIPKEHLEWLRSLPTYIDL-------------GDVWLTHAGLLPLSEQTSEQFC-WIREDFHSIP-KLVIIGHTIFPGVWLDIDTGAYHPWLTALDITNNLIYQINIFTNCPRRIIIGDVHGYYQGLMNLFDKIAPS------SADQVYFLGDLIDRGPQSAQVVDFVKQN-----D--YCCLLGNHEQMLLNVFGNRSHQAWL-Y---------S--GGQATITSYQAA-----QIPQEHIDWFLTLPTFIDL-------------GDYWLTHAGVKSVSEQTAEELC-WIREEFHSME-KLIIVGHTILPGVWLDIDTGAYHPWLTGLDITNNLVYQVNVFNNSGRRLIIGDVHGHYRSLYRLLELADPD------TDDQVYCLGDLIDRGPDSAKVVALVRSQ-----G--YTSLMGNHEHLLSQVLAFPDL-HWF-Q---------A--GGQATLASFGSW-----EALEELRPWLQQLPLYLDL-------------GEIWLVHAGVLPLSRQDANEFC-WIRDQFLARS-KTILVGHTIMAGIWLGLDTGVYHPWLTALDWDNQRVFQVQAQSNEGRRLIIGDVHGHYRSLYRLLELADPD------TDDQVYCLGDLIDRGPDSAKVVALVRSQ-----G--YTSLMGNHEHLLSQVLAFPDL-HWF-Q---------A--GGQATLASFGSW-----EALEELRPWLQQLPLYLDL-------------GEIWLVHAGVLPLSRQDANEFC-WIRDQFLARS-KTILVGHTIMAGIWLGLDTGVYHPWLTALDWDNQRVFQVQAQSNEMRTLAISDIHGCSIALETLLETVHLT------PKDTLITLGDYIDKGPDSKGVLDKLINLYKNY-R--LIPLKGNHEIKMLQARQSDPDCFWL-E---------F--GGRETLNSYS----TLANVPEEHWNFIQNLCVYWQT-------------DNHIFVHANLLSLKRQSEYDLF-WKKFNYQAP--KTMICGHTSKPINRICLDTWVCGGWLTCLELESGKIWQANQRGQIMRTLAVGDIHGCATAFDKLLEAIHLR------PQDRLITLGDYVDKGPNSKEVLERLLYLYENH-R--LVPLKGNHELMMLDAFQGKKKDFWV-I---------A--GGKTTLQSYP----PLLNVPDSHRDFIKQHCLWYET-------------DNHIFVHANLLPLHKQSNHDLF-WQKLYPRHG--KIVVCGHTSSPVNQICIDTWACGQWLTCLDVDSGKIWQTNQQGEVMRTLAVGDIHGCTTAFDQLLEAIDLR------PEDKLITLGDYVDKGPNSKGVLERLLFLYENH-Q--LIPLKGNHELMMLDAFQGKRKNFWL-L---------T--EGKTTLESYP----PLLNVPDSHWDFLKQCCLWYET-------------DNHIFVHANLLPLHKQSNHNLF-WQKLYPHHG--KIVVCGHTSCPVNQICIDTWACGQWLSCLDVDTGKIWQTNQQGEVMRTLAIGDIHGCSKALDHLLEIVNPK------PQDTLITLGDYVNKGRDSKGVIDRLISLHKQG-N--LIPLKGNHEIIMLQARNNPLKRLWL-E---------K--GGKATLKSYS----HLIKIPESHWDFLGKVCISYET-------------ANHLFVHASLLPLARQPEYKLF-WEKFQYPAA--KTMICGHTSKPINAICIDTWAYGQWLSCLDVETGKLWQVNQRGNFMRTLAIGDIHGCLEAFNLLLDVVALR------PNDTIITLGDYINKGPQSKGVIDQLIALHERG-Q--LVALKGNHELMILEARKSLEKFEWL-K---------K--YGTSTLLSYS----TLEDIPPHHWDFLQNICLWWET-------------KEHFFVHANILPLDQQLEDKLF-WAKFVDPQP--KVMICGHTSLPLNAICLDTWVCGEWLTCLDIDSGQIWQTNQQGKVGKIFAVGDIHGCYKKLRVLMDRIPINY-----KEDTLVFLGDYIDRGDESFEVVAYLAELRKKHPG--IVFLKGNHEELFFNYLSGEDEVSFL-F---------N--GGEQTLKGYMSPD-GDISVPKEHLNFFNALQLYYET-------------DDYIFVHAGLVPLEQQKPEDLL-WIRKPFIESS-KIVIFGHTPEVVVKIGVDTGAVYGKLTCIELPARKFYEA------GRLLAIGDIHGCHRALRSLLARLSPN------RGDRMVFLGDYIDRGPDPRGVIDTLLAVRRRVMR--CTFLMGNHERMLLDVLEGRNLPLYL-A---------N--GGLVTLLAYMTE--GQLRLPASHRRFFNGLQRFHAT-------------GSHIFVHAGLCPLSQQTEEDLL-WIRDAFLASD-KTVVFGHTPKPLLRIGLDTGAVYGVLTACDLHTRRLWQAREPNRD-MLWAIGDIHGCLNALETLINEISPT------PNDKLVFLGDYIDRGPDSKGVVDFLIELSKRT-D--CIFLRGNHEQMLLDVIDNGDDYLWV-I---------N--GATATWRSYGNL--QNLLYNDEHLEFFRNTQYYFIE-------------DKYLFVHGGVIPIEKQDKRDLI-WIREEFISKK-YIVIFGHTPDVFIKIGIDTGCVYGKLTAYNLTLSKKVEVECLNG-MGLWAIGDIHGCLRALERVIERISPS------EHDKLIFLGDYIDRGPDAKGVVDFLLLLSKMT-Q--CVFLRGNHEQMLLDVIDNNDDFLWN-L---------N--GAQATIRSYGNL--IQLETNEEHMSFYRNTKYYHIE-------------GKYLFVHGGVVPIEKQEPRDLI-WIREEFILKR-FVVVFGHTPEVYFKIGIDTGCVYGKLTAIEVNQKVVIQEDCRNVR-MIYAIGDIHGCLESLKKLIEKINPS------RTDMLIFVGDYIDRGPNSKGVVDFLIKLSRSR-K--CIFIRGNHEQMLLDYLNGGKTKLWH-F---------N--GMEYTINSYG----GIDKIPEKHIRFFEKTILFHET-------------DEYVFVHAGVIPLNKQKDGDLL-WIRDEFIYAE-KVVIFGHTPEPLIKIGIDTGCVYGKLTALRLDDMCFFSVKSIF--MALIAIGDIHGCARTLDALLDRLAPT------RDDQLVFIGDYIDRGPDARGVIERLLRLREEI-S--CVFLRGNHEALMLNYLDRGEADLWF-I---------N--GGLTTLNSYRND---GIRIPEEHEAFIRETLLYYDT-------------PDFFFVHGGLLTIAEAHTDLFL-WEREHLNAPR-KPVVCGHTPEPINLIAIDTGCVYPRLTAVRLPERTFISIPRQDLIMGLIAVGDIHGCLESLNALLDRLNPS------SDDHLLFVGDYIDRGPDSRGVIDRLLDLRESI-S--CTFLRGNHEAMMIDYLDSGAFSLWR-M---------N--GGVSTLQSYLKGEGSEVHIPAAHAEFVRDTKLYHET-------------DDFLFVHAGLLTVEEPDEEVLL-WERGHLEASG-KTVVCGHTPDPISLILIDTGCVYHRLTAVHLPQREFIDVPYADG-MGLIAVGDIHGCLESLNALLDRLNPS------SDDHLLFVGDYIDRGPDSRGVIDRLLDLRESI-S--CTFLRGNHEAMMIDYLDSGAFSLWR-M---------N--GGVSTLQSYLKGEGSEVHIPAAHAEFVRDTKLYHET-------------DDFLFVHAGLLTVEEPDEEVLL-WERGHLEASG-KTVVCGHTPDPISLILIDTGCVYHRLTAVHLPQREFIDVPYADG-TRTFAIGDIHGHRDRLEALLRRLPLDR-----ERDTVVFLGDYVNRGPDSRGVIDLLLGLQRTCPG--AVFLRGNHEQILLDYADTGDALLPL-L---------RFLGVEATLRSYGVD--GLACLPPEHAAFLRGLAFAHET-------------ATHVFVHAGLPRSETQRLDSRR-LVRRDMAPHD-RTVVFGHSSTPLVRIGIDTGAGGGMLTALELPALRFHHA------GKIFAIGDIHGCYDKLISLMDRLPFDL-----HSDTLIFLGDYINRGSQSKEVIEYLLKLKQSSEN--IIFLKGNHEHALLEYAQTKDQYLRL-L---------RSMDVEPTLKSYSDA--DLGFLPPAHLDFLNGLLTYYKT-------------DDYLFIHAGVEDPDGCSLDRLL-SVRDTFLRYE-YTVVFGHTPMPLVMIGIDTGAVYGMLTAVLLPDLRFFHA------GKLIAIGDIHGQSDALRRLLDDLPYRP-----GRDRLIFLGDYINRGPDTRGVLEVLSALRRDDPG--AVFCLGNHEEALLRYAAGGDPDLRL-L---------RTLGIETTLESYGDL--GLSFLPEEHREFLLGLESFRRI-------------GPYVFVHAGLLPPEACPPDCLL-SVRGAFLTGP-LTVVFGHTTTPLVKIGLDTGAAWGALTALVLPDMVFLHAPGDRFLGKLIAIGDVHGQSDALRRLLDDLPYTP-----GRDRLIFLGDYINRGPDTRGVLEILATIRRDDPG--AVFCLGNHEEALLRYAAGGDPDLRL-L---------RTLGIETTLESYGDL--GLAFLPEAHREFLLGLESFRRI-------------GPYVFVHAGLLPPEACPPDCLL-SVRGAFLTGP-LTVVFGHTTTPLVKIGLDTGAAWGALTALVLPDMVFLHAPGERFLARLIAVGDIHGQADALRRLLDDLPYRP-----GTDRLIFLGDYINRGPDTRGVLDLLTDIARQDPG--AVFCLGNHEETLLRYADEGEPDLRL-L---------RGLGIETTLRCYGDP--GLSFLPPEHQAFLRALVPYARI-------------GDMLFVHAGLLPPEECPTDCML-SVRGAFLSGP-LTVVFGHTTTPLVKIGLDTGAAWGALTACILPDMELRHVFI-----MIWAISDIHGMYDNLIKVLNQIP--------ENDKIIFLGDYVDRGPGSRQVLDLLFKLKNR-----AVFLKGNHEDMMLDYFENTGKGAWF-R---------N--GAQATLDSFNND------IEEKYLDFIRNLKLYHGT-------------QKYLFVHGGIISLSDQAERDLL-WIRDDFYMSD-YIVIHGHTPYITGSIDIDTGCVYGKLSALGISNDNKYDIISI----MIWAISDIHGMYDTLISLLKRIQIK------DSDTMIFLGDYVDRGPDSKKVLDLLITLSKQRN---RIFLKGNHDDMMVDYCQKTHEGVWF-Y---------N--GALSTIKSFNNN------IGEEYINFLKDLPLYYEN-------------EKYLFVHAGVKSLSKQDKWDLL-WIRDEFLSMS-YTVIHGHTPYLTGSVDIDTGCVYGKLTAFGITEDNRHVVLQAV--MRVYAVGDIHGRLDLLEIMLDLVDADQHERGIRPALIVFLGDYVDRGPSSKEVVDAFIGELGEALS--PVFIKGNHEALLMSFLYDATPNFWL-K---------N--GGDAALLSYGLDPDFREALPASHLSFYCNLKPSFRI-------------GGYFFVHGGVVPLDQQREEDLL-WIRDPFLTSD-AVVVHGHTPEPQLRIGVDTYAFKSRLTAVGLEGTERWILSTAS--VRVYAVGDIHGRLDLLEQLLAQIDRDAASGADLVKYLVFLGDYVDRGPDSAMVIERLCREPLPGFG--AIHLRGNHEAAMMDFIEKPEAPDWL-E---------Y--GGRATLASYGVPAPFAAALPPHHRTFLAGLRSSVAI-------------GDYLFVHAGILPLHRQRDEDLL-WIRREFLTSH-KLVVHGHTIQPDIRIGIDTGAYASRLTALVLEGGERRFLCTI---MRVYAVGDIHGRLDLLDQMMGQIARDAAQAPNLLKYIVFLGDYVDRGPDSRLVIERLACGLPPVLG--AVFLRGNHEDTLLGFLSDLRVPGWL-T---------Y--GGDATLESYGIPAPLNSLLPAHHRAFLTGLRCHLTI-------------GDYHFVHAGVVPLDRQEDKDRL-WIRDAFLASR-KVIVHGHTIEPELRIGIDTGAYATRLTALVLEGAERRFLCTV---MRVYAVGDIHGRLDLLDQMLGQIAHDAGQAPNLLKYLVFLGDYVDRGPDSRLVIERLACGLPPVFG--AVFLRGNHEDTMLSFLSDLRIPGWL-T---------Y--GGDATLESYGIPAPLNGLLPPHHRAFLTGLRNHLTI-------------GDYHFVHAGIIPLDRQEDKDRL-WIRETFLASR-KIVVHGHTIEPELRIGIDTGAYATRLTALVLEGTERRFLCTV---VRIYAVGDLHGCADLLAGAFDLIDADLARSRPEQAIQVFLGDYIDRGPDAKRTIDLLIDRGQRHE---TVFVRGNHEALLLRLLDDPKMPNWI-K---------L--GGMTTLMSYGITISLAAAIPSAHTDFLANLVPFFSC-------------GDYFFVHAGVVPLDKQSEEDLM-WIREPFLSSD-KVVVHGHTPEPEIRINIDTGAYATLLTVLSIQDDKVEFHSSSRSRLRLYVIGDVHGRLDLLDDLSKQIAADLDDAP-ADVLTIFVGDYIDRGRESAGVIDRLNRGEFPTP---FHALRGNHEEILLKFLEDESVESWR-K---------F--GGLETLHSYGVDVSLLELMPETHRRFLEGTDLFASF-------------GDYLFVHAGVVPVHLQNADDLL-WIREEFLRFR-KVVVHGHTPAPDVRINVDTGAFATVLTALVLEGADRRFLQTRAP-TRVYAVGDIHGRFDLLWRLAGAIEADLAARPVARVVEVYLGDYVDRGPDSARVVDWLSRPAAGGRE--RICLMGNHEHALLSFLADPGLAQWR-Q---------F--GGGETLISYGIDLPLRAALPVSHLRFLRALPALHRI-------------GGYAFVHAGVVTLDAQVETDLL-WIRQEFLDYP-AVVVHGHTPTIDLRINIDTGAYMTRLTCAVLDADGVRFLQTTREGKILVAIGDIHGRLDLLDRLLPKISEHLDG---RAARLVFLGDYIDRGPDSAGVLDRLIGVRESFSD--CVFLKGNHEEALLDFLAAPEEASWL-G---------W--GGDATLLSYGLDTDFAAALPDDHFRFLLDLELFHRA-------------APYQFVHAGLLPFDRQIERDLL-WIRDRFFNAN-WVIVHGHTPAPDNRINVDTGAVWSQLTAVVLDGEDRRFLTS----KRTFVIADIHGCYKSLKALVENLQPT------HEDQFIFLGDYIDRGPDSKAVINYLIYIKEHYKN--CVFLRGNHEQMFLDAHQSIAAERWI-I---------N--GGEEVMISYGLK--NHDHVPYHVQDFISNTFYYFQD-------------ERFIFVHAGIAESPLKDYNSMM-WIRNAEITHT-RIVVHGHTPLDTIEICLDNGCVFKQRTGLGLHSNRLYVQNNIDF-KRILVISDIHGEIEKFEQLLKEAQYDA-----KQDQLILLGDYVDRGPNARAVIEKVKELKEE--G--ALILKGNHEDMMIKALTTNEENHWVKR---------N--GGDKTLYSYGFLEELQSSVLEEHIKFIQELDHYIET-------------EEYIFVHAGVKRVSESEPYTLM-WIRNEFHNG--KVVVFGHTETLHSIIGIDGGAVYGQLNCLELPSKKVYVIKN----KRILVISDIHGEIEKFEQLLEEAQYDA-----KKDQLILLGDYVDRGPNARAVIERVKELKED--G--ALVLKGNHEDMMIKALTTDEENHWVKR---------N--GGDKTLYSYGFVEELQSHVLEEHVKFIQELDHYIET-------------EKYIFVHAGVKRVSECEPYTLM-WIRNEFHNG--KVVVFGHTETLHGIIGIDGGAVYGQLNCLELPSKKVYVIKS----KEFFVIGDVHGKFELLLDILKKWNE-------KRQQLIFLGDLIDRGENSKACLELVWSLVREK-G--AICLTGNHERMFLAWLRDPIDDHYR-R---------N--GGDTTINSLLGRPLLEQY--EDLIDFVKSCPYHLET-------------EDYIFVHAGVLPDWRTSNHDKV-WLRTPFHEAE-KMIVFGHTPNLYQKMGIDGGAVYGVLHGIVLDGTGLVQDYIVGAVKEFFVIGDVHGKFELLLDILKKWNE-------KRQQLIFLGDLIDRGENSKACLELVWSLVREK-G--AICLTGNHERMFLAWLRDPIDDHYR-R---------N--GGDTTINSLLGRPLLEQY--EDLIDFVKSCPYHLET-------------EDYIFVHAGVLPDWRTSNHDKV-WLRTPFHEAE-KMIVFGHTPNLYQKMGIDGGAVYGVLHGIVLDGTGLVQDYIVGAVQRILVASDIHGHGDALIKLLSEAVYNA-----ETDQLVLLGDYVNNGPDSVGTLRLVQKLVNKG----AIALVGNHELRWLERQD---------------------------------------SEAQAWHKFLSGLPYIKVL-------------DSYIFVHAGIVPIDKQQCEHVT-AHHSVALNQH-KTIIHGHVPEIHIMIDIDTGAGHNYLTLVDLTNACSYSVNVSHKDGRLFVASDIHGHGETLRQLLETAEYSP-----GNDQLVLCGDYVNNGPDSEGTLELIQKLQKD--G--AVVLFGNHELRWLEEIA----TEFIMH---------H--KMKVTYQRIQKD-----WGKLKWRSLLESFDKYYMT-------------DDFLFIHAGFVPLEKQTAAEVT-GYDKTKDLQH-KYMVHGHVPEIKVSVNIDTGAGHGYLTLLDLTNSKQYCQRVVMKEMRTIVVGDIHGCYAELLQLLAKVEIA------EEDCLVSLGDIVDRGIDSVKVYDFLKNRPN------TIVLMGNHERKHLRQTLSYSQ--------------------------------QFGDSYDEFLEWISHLPYYHET-------------ESAIFVHAAVIPIEEQREEVLC-WSQ--------KPVIFGHRVHPLITYGIDTGACHGTLTAIILPSFEIVQVQAAKDYMRTIIVGDIHGCYEELLQLLTKAQIT------KEDCLISLGDIVDRGVDSVRVYDFLKNRPN------TIVLMGNHERKHLRQTLSYSQ--------------------------------QFGDRYPEFLEWVSHRPYYHET-------------DAAILVHAAVIPIGEQRPEVLC-WSQ--------KPIIFGHHVIPLIIYGIDTGACHGKLTGLILPSFEVVQVQAPQDYMRTLVFGDIHGGYRALVQVMKRANVT------RDDHLIFLGDYVDGWSESDAVIDELMRIKKEYKK--VTLIRGNHDDLVQQWLEGKTMPKWL-Q---------H--GGQSTIDCYEKR---SAQEIQWHIEFYKTFEDYLDD-------------ENRFFCHAGFGPEYEWHSTAFY-WDRDPLYPKRLEEIYIGHTPVPVNIWNLDTGAAFKSLTVMDVDTKEFWQSDALPSLGPLFVIGDVHGYLDELLAALHQLIDTEGHWSAGRSRIWFLGDFTDRGPDGIGVIDLVMQLAAEAAAAGCRALMGNHELLFLGASR----AAWRLN------------GGQQH---------DLERLQPHHISWLSRLPAMALE-------------DGHLLLHSDTLEYGETIADVNDAW--DAFFTKRFYRVVHGHSPGPYIAIAMDGGVTMDRLLVARLPLN-----------GPLYVVGDVHGYLDELKAALRELIDAEGHWSAGQSRLWFLGDFTDRGPDGVGVIDLVMQLSAEAAAAGAKALMGNHELLLIGAKR----AAWRLN------------GGQPT---------DMERLQDHHIAWMSRLDAIALE-------------DNHLLLHSDTLEYGSSIEEVNDAW--ELFFTKRFGRVVHGHSPGPHLALAMDGGVTMERLLVAQLPLRG----------GPLYVVGDVHGYLDELKAALRELIDAEGHWSAGQSRLWFLGDFTDRGPDGVGVIDLVMQLSAEAAAAGAKALMGNHELLLIGAKR----AAWRLN------------GGQPT---------DMERLQDHHIAWMSRLDAIALE-------------DNHLLLHSDTLEYGSSIEEVNDAW--ELFFTKRFGRVVHGHSPGPHLALAMDGGVTMERLLVAQLPLRG----------GPLYVVGDVHGYLDELVAALRALIDENGGWAAGNARLWFLGDFTDRGPDGIGVIDLVMRLSAEAAAAGCKALMGNHELLLIGAKR----AAWLLN------------GGQKH---------DMDRLQDVHLQWMSRLDAVVRE-------------DDHLLVHSDTLEYGQTIEDVNETW--DVFFTKRFHRIVHGHSPGPHVAIAMDGGVTMAKLLVVQLPLNG----------TPLYVAADIHGHRTEFRAVLRALADENGHWSGGRARLWLLGDHVDRGPDGIGVIEDVRRLAAQARDEGVGALLGNHEVQLLAAHR----GGWARF------------GGQEA---------DLRGLTPSHLEWLAALPAAALV-------------DGHLLVHSDTLELGTSVAAVNAAWL-EFSMSSRGSVLVHGHSTAALRVLAIDGGAYLGRILLTRL--------------

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GDxHG GDxVDRG GNHE HGG VVSGH IDEG Motif 1 Motif 2

Supplemental Figure S2: Alignment of the phosphatase domain of RLPH protein phosphatases from both Prokaryotes and Eukaryotes. Candidate RLPH phosphatase sequences identified as detailed in Materials and Methods were aligned using MAFFT. The alignment was visualized in GeneDoc and manually edited to remove the extreme N- and C- terminal regions outside the protein phosphatase domain, plus poorly aligned regions, prior to phylogenetic tree inference. Two conserved bacterial-like phosphatase motifs (orange) were identified in addition to the known canonical PPP-family protein phosphatase motifs (blue). Of the two bacterial-like PPP-phosphatase motifs, Motif 1 represents a novel region of conservation. Motif 2 was previously reported (Andreeva and Kutuzov, 2004). The gene identifiers of each sequence used here are located in Supplemental Table S1.

PrpE_1 :PrpE_2 :PrpE_3 :PrpE_4 :PrpE_5 :PrpE_7 :PrpE_10 :PrpE_9 :PrpE_8 :PrpE_6 :Q0ALJ2_MARMM :AaALPH :EhALPHa :BnALPH :CmALPH :PtALPHa :TpALPHb :EsALPH :CpALPH :F8CMG1_MYXFH :Q1CWE7_MYXXD :H8MWN3_CORCM :Q097S7_STIAD :A9ER55_SORC5 :EhALPHb :EhALPHc :CocALPHa :AqALPH :BfALPHa :BfALPHb :SkALPHa :SkALPHb :LgALPH :CtALPH :GtALPHa :CgALPH :CocALPHb :PcALPH :PrALPH :PsALPH :PiALPH :PuALPH :IsALPH :AmALPH :RpALPH :SpALPH :CvALPHb :E3FDL0_STIAD :F8CB73_MYXFH :Q1DC62_MYXXD :LmALPHb :TbALPHb :TcALPHb :TbALPHa :TbALPHc :TcALPHa :A7HDV6_ANADF :B4UIJ2_ANASK :B8JET4_ANAD2 :Q2ILE6_ANADE :CrALPH :VcALPH :FcALPH :TpALPHa :PtALPHb :CvALPHa :SaALPH :E4NPT8_HALBP :Halosarcin :G0LN38_HALWC :J3A001_9EURY :Halogranum :D4GUB7_HALVD :E7QTB4_9EURY :Halorubrum :G0I0G4_HALHT :Halosimple :C7P488_HALMD :Natrialba :D2RRW5_HALTV :F8D2X2_HALXS :I7BUV9_NATSJ :Natronorub :Halovivax :LmALPHa :OdALPH :FgALPHb :FgALPHa :AnALPH :ApaH_1 :CsApaHb :HhApaH :RprApaH :SrApaH :BiApaH :SsApaHa :SsApaHb :RcApaHa :RcApaHb :AaeApaH :AgApaH :PotApaH :HvApaH :XtApaH :PscApaHa :HmApaH :AstApaH :OsApaHa :OsApaHb :PscApaHb :LsApaH :ApaH_9 :ApaH_3 :CarApaH :OvApaH :ApaH_5 :ApaH_6 :ApaH_8 :ApaH_10 :ApaH_4 :ApaH_7 :F9ZYF7_METMM :A0L5C1_MAGSM :ApaH_2 :Q7NN25_GLOVI :PA3087_1 :PA3087_5 :PA3087_2 :LsPA3087 :PA3087_9 :PA3087_8 :PA3087_7 :PA3087_3 :PA3087_10 :PA3087_6 :PA3087_4 :BnPA3087 :GtPA3087 :PscPA3087 :

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160MAYDIISDIHGCYDEMTALIQKLGYTEGRVLVFAGDLTDRGPKSIEVIRFVAGGAVRYVPGNHCNKLYRYLKGNPVKVKSVSEQFMKLYETAPLYDILELVVAHAGIRADDIGKYTRRVKGRPIRRD--WAAAYGKAWVVYGHTPVKEPRKVNRTINIDTGCVFGNMQFDIIGDVHGCYDELMELIDKLGYEDGRLLAFVGDLTDRGPHSLEVIRLVSHKTAYYVPGNHCNKLYRYMIGRKVQVIEVIAQFKELYEQAPLYHSFKLVITHAGIREDDIGSYGKRVEGTPVRRD--WAATYGDWWIVYGHTPVRRPRIIHRTVNIDTGCVFGGMKIDIIGDVHGCLEELEELLFKLGYQNNRQIVFVGDITDRGPDSIKVIKLVYQKLAYYIPGNHCNKLYRFFQGNKVMENNIKHKFIELYERSPLYLHLNVIIAHAGIPEHLIGKKDKRTKGKPIRRD--WAKHYGDSWIVYGHTPVLEPRVVNHTINIDTGCVFGNMKYDIIGDIHGCLQEFQNLTEKLGYNDQRKLAFVGDITDRGPHSLRMIEIVWEKVAYYAPGNHCNKLYRFFLGRNVTINMIKEKFITLYEQSPLYHVLRLLVCHAGIRQDYIGRQDKKVQGSPVRRD--WAKEYGTTWIVYGHTPVKEPRFVNHTVNIDTGAVFGGGPFDIIGDVHGCCDEVEQLLEKLGYREGRKALFLGDLVDRGPRILDTLKLVRNGSGMCILGNHEHKLIQKLAGKNVKVDQDIEEIQSFLKSLISHYVLKLVVAHAGLREELQGRGSGYVRGLPIRRN--WATDYGSAMVVHGHTPVATAEWLNNTIDIDTGCVYGLGPFDVIGDIHGCADELEDLLAQLGYREGRRAIFLGDLVDRGPRIPDVLKIVMSGTAFCVPGNHDTKLLRWLGGKDVKI---KKTVAKFLDSLIGHYVLKLVVAHAGMKESMQGRSSGAVRGLPVRFD--WASEYGSAMVVYGHTPVPQPQWLNNTINIDTGCVFGGGPFDIIGDIHGCYDELKMLLEKLGYLEGRKVLFLGDLVDRGPKITEVLKLVMGGIALCVPGNHDVKLLRKLSGRDVQI---IEEVKAFIDGLVSHYVLKLVVAHAGMKEEFQGRGSGKVRGLPVRYD--WASDYGKALVVYGHTPQAEVLKVNNTINIDTGCVFGGGPFDIIGDIHGCYDETVDLLTKLGYQQNRQVIFLGDLVDRGPGSPAVLKLVMSGVAWCVPGNHDLKLHKKLKGKQVAI---IGQVKEFLYGLVSHYVFKLVVAHAGIKEEMQGRGSGAVRGLPVRYH--WANEYGNAKVVYGHTPVPEAEWLNKTIDIDTGCVFGGGPFDIIGDVHGCYDELKNLLEKLGYRQERRIIFVGDLVDRGPNSPEVLRLVMDSIAFCVNGNHDDKLKRKLQGRNVVI---KASVLEFLESLSSYYILKLAVSHAGIKEKDLGRSSERISGLPLRYP--WDQEYGNTLIVYGHTPVCEAQWLNNTINIDTGCVFGGGPFDIIGDIHGCAGELESLLEELGYTEGRRAIFVGDLVDRGPRSPDVLRLVKGGTAFCVIGNHENKLVRKLNGRNVQL---AEEMRVWLDGLISHYVFKLVVAHAGLSEDMHNRASGKVRGLPVRAD--WAANYGRAKVVYGHTPTPEAEWVNGTICIDTGCVFGGGPFDLIGDIHGCFDELVSLLARLGYDKGRRLVFLGDLVDRGPDSPAVLRTVMSGRGHCVVGNHDDKFRRWLAGRDVKL---RRELLAFIDTLPHHLILRLIVAHAGVQADMHGEDSKRVRGLPVRLD--WARNYGEATVVHGHIAEPDVRERNNVICVDTGCVFGGRRFLVVGDVHGCRDELELLLAKAAYDTTTQLVLVGDLVNKGPYSAGVVRWCRERGALCVRGNHDDHAVDHWQKHFHL-KELSAADGAWLEALPHTLSLDAIVVHAGLAPDVPLDGQEPKHMTRMRSLASWAATRERPLVVFGHDAKRGLQVHANAVGLDTGCCYGKSRTILVGDVHGCLDELKSLLQACGFDSTDHVVLVGDLVNKGPHSAETVAYARESGFACVRGNHDDAALFAHEARTEAGDALGEADLAFLRELPHTLRLEVLVVHAGVVPGVPLAEQRAEDMTTMRNLVAWAEEWGVRHVVFGHDAKRRLQRHEHATGLDTGCCYGGQRTILIGDVHGCFVELKALLKKARFNQSDRLVLAGDLVGKGPYSRQVVEFVRKMGGIAVRGNHDHRAVKAHAGML---DELGAESLDWLATLPLSIFLKAYVVHAGVMPHTRVEQNTPELLMNLRGLEPWAQSWGPELVIFGHDATRRLQVHKYALGLDTGCVHGGPRVIAIGDVHGCITELQDLLRVCDYRG-DELILLGDLVAKGPDSQAVVQMAREIGARAVRGNHDHEVIRCREAMMRGHRQLSQQEHEWLRSCPWYIRSETVFVHAGFQPDVPFEEQLPRHMMNLRSVMAWARLWGPLRVVFGHDAYMGLQLWDKCIGLDTGCVYGGPRVIAIGDVHGCIDELQDLLRQCDYRPGDLVVFLGDLVCKGPDSISVVQMAREIGAFGVRGNHDFEVIRWHQAIKSGVSCLSKADMKWMNSLPWYLSSGSLFVHAGFVSGIRLAKQNPRLMMNMRSIWPWARLWGPQTVLFGHDADRGLQQYEHAIGLDTGCVYGGPYKGELGHVHGCIDELQALLRKCDYHPGDLVVFLGDLVCKGPDSLSVVQMAREIGAIGIRGNHDFEVVRWHQAIKSGASALSTADLKWMYSLPWFISSNALFVHAGFVSGIRLAKQNPRLMMNMRSIWPWARLWGPQTVFFGHDADRGLQQYEHAIGLDTGCVYGGPRIVAIGDVHGCVNEMKDLVRKVEYWPGDLLLFLGDLVAKGPNSAGVVRTARELGGVSVRGNHEFEVLRWLNVGENENMSLGEDDGLWLKNSPWYFQCDALFVHAGFIPGVSMKRQNPRMMMNMRSLRPWAREWGPDTVFFGHDAARGLQVLDQAMGLDTGCVYGGKRLIFIGDVHGCIDELQDLLKECDYSATDRVIFVGDLVAKGPDSQAVLQLAREIDALSVRGNHDEATLRVRHAWMNPGTTLKEEDWEYLSSLPYYLTIPCVVVHAGLAPGLPLRWQRPIDMMYMRVIVPWAGEWGPELVLFGHDAARGLQLWPHAVGLDTGAVYGGMRTLFIGDVHGCAEELDALLTRCGWRPDDRVVLVGDLVAKGPDSAGVVRRAREQGFLAVRGNHDAHVLRWHAGRGPRGDTLTPEDWAWLESQPLYRCFNVVAVHGGLVPGVPLEAQKEDELLNLRSIAPWASLWGPELVIFGHDAMRGLQRYPHAVGLDSGCVYGGMRTLFIGDVHGCAEELDALLTQCAWQPDDRVVLVGDLVAKGPDSAGVVRRAREQGFLAVRGNHDAHVLRWHAGRGPRGDTLTPEDWAWLESQPLYRFFNVVAVHGGLVPGVPLEAQKEDELLNLRSIAPWASLWGPELVIFGHDAMRGIQRHPHAVGLDSGCVYGGMRTLFIGDVHGCSSELDALLKACDWQPGDRVVLVGDLVAKGPDSAGVVRRAREHGFQAVKGNHDAHVLRWHGGHASKGDTLSAADWAWMERLPSYLRFNALAVHAGLVPGVPLEEQKEEFLFNLRSIEPWGSLWGPELVIFGHDAMRGLQKHPFAVGLDSGCVYGGMRTLFIGDVHGCAEELDALLAVCGWQPGDRVVLVGDLVAKGPDSAGVLARARERGLLAVRGNHDEHVLRWHQGYVKPGDTLAPEDWAYLASLPLYLRLNVVAVHAGMLPGVPLESQHREHLLNLRSIEPWASHWGPELVLFGHDAMRGIQRYPHALGLDSGCVYGGPRTIIIGDVHGCRDELARLIEHVGLVSGDRVVMVGDLIVRGPDPCGTLDLLREVGAISVRGNHEDRLLRWRAGRSDPRQQLRKRDWAWLETLPYWLDLGLRVVHAGLIPGLPIERQDPHTLMYVRCLTLWGQTYGPPHVVFGHNARSEPQMHAWATGIDTGAVYGG-RTMVIGDVHGCHRELQQMLARLSPGPSDRVVFVGDVISKGPDPVASLRLARNAGSEILVGNHERNLLTWLKQRDQGVEQLTRGEVEWLRGRPDRLALNAIVAHAGLRAGVPLAQQQHADLTAMRSLVSWAASWGPTHVIFGHDSRRRLQLHPFATGIDTGCVYGG------------MRATESLLGKLAFSARYRVVFVGDVISKGPDPVASLRLARNAGSEILVGNHERNLLTWLKQRDQGVEQLTRGEVEWLRGRPDRLALNAIVAHAGLRAGVPLAQQQHADLTAMRSLVSWAASWGPTHVIFGHDSRRRLQLHPFATGIDTGCVYGGGQIIVIGDVHGCPVELNALLDKCKFQGSDKVVFVGDLVNKGEQSAEAVHLARQIGGISVRGNHDEMALERYEMWKK--EQFSEEDVEYFRQMPFSLSIGVLVVHAGIVPGTPLEDQLLDDLINMRHVQPWANIYGPQHVIFGHHARRRLQPCRFATGIDTGCVLGDRRLLVVGDVHGCYDELVQLLDKAGGRPGVLVVFVGDVCNKGPLNVESIRLVREVGGYCVRGNHDEICLLEWLKHSEG-SRLSKEEMDWYFELPFSIHFEVLVIHAGLVPGVPIEEQSHHDLLHLRNVQPWAQTWGPDHVYFGHDAIRFLQRYPFATGLDTGCVYGGKRVFFIGDVHGCYDEMMQLLNKADALDDTVVIFVGDMVNKGPKSREVIDFLRRSKVYAVKGNHEDHVLREYDNSRDP-GKLTLEEAQYLRDLPYTISLNIIAVHAGLVPGRPLEEQSDYEMMTMRNLKPWAAEWGPQHVVFGHDAVRRLQLYDHATGLDTGCLYGGKRVFFIGDVHGCYDEMMQLLHKADALDDTVVIFVGDMVNKGPKSREVIDFLRHSKVYAVKGNHEDHVLREYDNSQNP-GKLTLEEAQYLRDLPYTISLNIIAVHAGLVPGRPLEEQSDYEMMTMRNLKPWAAEWGPQHVVFGHDAVRRLQLYDHATGLDTGCLYGGKRIVIIGDVHGCYDELQEMLDLTGARNDTVVLFVGDLVNKGPKSKEVVNLVRSKNAQSVRGNHDEAVLREYANREKDSTASDKSERDFLTNLPYTITVNILIVHAGLVPGKQLLQQKTQDMVTMRNAYPWASLWGPHHVYFGHDAKRKLQLYDYATGLDTGCVYGGKRIVIIGDVHGCYDELQEMLDLTGARNDTVVLFVGDLVNKGPKSKEVVNLVRSKNAQSVRGNHDEAVLREYANREKDSTASDKSERDFLTNLPYTITVNILIVHAGLVPGKQLLQQKTQDMVTMRNAYPWASLWGPHHVYFGHDAKRKLQLYDYATGLDTGCVYGGRPVFVVGDIHGCCDELEEIVTEARKEKDTLFVFVGDLVNKGPKNSEVLDFLESLGHYAVRGNHDEVILKELHKFNTQPKKLTRIQVEYLQQLPYTIQINSIIVHAGLIPGKPLELTDFNTFTNMRNIEPWTSLWGPEHVYFGHDAKRKLQLLPLATGLDTGCLYGG-RVVVIGDVHGCFDELQDLLRVHNLMEDTVLVFCGDIINRGPKNQEVIQFIRNMGAYSVRGNHEDRVIYEWLNFHKRSTTLSSEDIDFLCSLPYTLSIETIVLHAGMDPWKCLCKQQPKDLVLTRNIVPWISCWGPQHVYFGHDARRGLQERRFGTGLDTGCVYGNGRVMIVGDVHGCCDELEELLRLHH--EGDLLILAGDLVNKGPKSVEVVRLARRMNAMAVVGNHEISSLRGYFARSGGKDGLCVEDVEFIRSLPFTISINVIVVHAGLVPDLSLAEQDHRHMVTMRNLEPWAALWGPSHVYFGHDAKRRLQLYKHATGLDTGCLYGDRKVLIVGDVHGCLREMEELLQEAKSKQEILPIFVGDLLSKGPFPVETLKKLQKIEHYAVRGNHDEAVLRQALSLKKEEPNLSDDDIGYLRELPYTISISVIIVHAGLVPGIPLTEQELTNMIIMRNLEAWASFWGPDHVYFGHDARRKLQKHAHATGLDTGCVYGNGRLIIIGDVHGCVKELKELLEEAEYVGEDTVVLVGDLVDKGPYPLEVLAEARRLKFHSVRGNHDDEVLAAYEALAR--KDLPAAAAQWLHALPFSLRIGVTVVHAGIVPDVPLERQSLGDMYLMREVPPWAAVWGPEHIYFGHDHQRGLQERPYATGLDTGCCYGDTRLLVIGDVHGCFDELQLLLETCHFSLEDRLVFVGDLVNKGPKSLDVVRFVRESDSLCVRGNHDDAALSAYYKWVEGGEHFLPDDVEFLEQLPFSLSLDIIVVHAGVVADVELEQQKPFDLYKMRFVEMWAKVWGPRHVYFGHAASAGLQQESFATGLDTGCCYGKTRLLVIGDVHGCFGELQLLLEACDFRASDRLVFVGDLVNKGPRSLDVVRFARDSDALCVRGNHDDAALSAYYQWVQGGELLEEEDVAFLEQLPFSLSLNAIVVHAGVVDGVGLQQQKPFDMYKMRFVRMWAKVWGPRHVYFGHA----------------------SRLLVIGDVHGCLDELQALLAACHFAAGDRLVFVGDLVNKGPKSLDVVRFVRDSGALCVRGNHDDAALSAYYRWVQGGEQFEPRDVAFLEQLPFSLSLNIIVVHAGLVEGVELQDQKPFDMYKMRFVKMWAKVWGPRHVYFGHAASAGLQV------------GGGNRAGAPGRGSSCARELQLLLSACDFSPNDCLVFVGDLVNKGPKPLDVVRFVRESGSLCVRGNHDDAALSAFYQWINGGEHFKPEDVEFLEQLPFSVSLNIIVIHAGVVPEVNLEEQRPVDMYKMRFVEMWAKVWGPRHVYFGHAASAGLQVRRLLRRN--------VRAVIVGDVHACYEELLELLHACAFDASDTLVLVGDLVNKGPQPLEVVRFARETKALCVRGNHDDAALSAYYAWQANGEQFTPEDVQFLEQLPFTVTLNAIVVHAGLVPGVPLSAQQPRHMYKMRYLTQWATQWGPLHVYFGHDAVPGLQQEAFATGLDTGCCYGRKQVLIIGDIHGCYDELMKLLHSQRANKDTLKLFVGDLVNKGPKSEQVLDFIMGNNCQSVRGNHDEVVLREYLASRDP-GRLSGQQARFLQELPYTLSLNALVVHAGLVPGQGLATS-PRNMVSMRNLVPWGSLWGPAHVYFGHDAKRMLQTWPRCTGLDTGCVYGNKQVFVIGDVHGCYEELMDLLAVAKVKKHTLKLFVGDLVNKGPKSEEVLDYLISDRCHAVRGNHDEVVLKEYYASRSL-NRLTARHVRYLEQLPYTLLLNTVIVHAGLVPGQGLSTS-LADMVTMRNVEPWGQVWGPQHVIFGHDAKRNLQTWQHCTGLDTGCVYGNKQVFVIGDVHGCYEELMDLLAVAKARNDTLKLFVGDLVNKGPRSEDVLEFLMNNHCHSVRGNHDEVVLKEYYASRNP-KQLTVCQIRYLEQLPYTLIMNTVIVHAGLVPDEGLSTS-LVDMVTMRNVEPWGQVWGPHHVIFGHDAKRKLQKWRYCTGLDTGCVYGNKRIFVIGDVHGCYDNLLTLLHVADIDPNALLIFVGDIINKGPKSLEVLNFVRSSNSYSVMGNHERAAVRKLRLIKMNVHDLNGSDYEYLQELPYTISINAVIVHGGLLPGKPLEEHTQDEMLLMRNIQLWGELWGPRHVYFGHHALEGLQRYPYATGLDTGCVYHGRRVLVVGDIHGCYEELLDLLDKCSYAGEDVLVLVGDLVNKGPRSAEVLRFVRDGGVFAVRGNHDDSSLAAYTRLSSGDRDLDASLATVLEQLPFTLRLDALVVHAGLVPNIPVGEQRMMDLLHMRNVLAWASAWGPPHVFFGHDARRLVQLERCATGLDGGCVYGNSRTIVIGDLHGCYDEALELLEKVGATSQDRILFVGDLVDRGPKPRECVELAMR--HEAIQGNHEEKHLQQRHRAD---RALEPEHFDYMARLPFYLRLNAAVVHAGVMPGKRLEDQDPYHLLHAQCIRFWTHHWGPERIIFGHTVFDQPLVTPHAVGIDTGCVYGRRRTIVIGDLHGCYDEAVELLDKVGATSSDRVIFAGDLVDRGPKRRECVELAMR--HEAVLGNHEEKHLQQRHRAD---RVLEAEHYAWMAGLPHYLRLNAIVVHAGMLPGRPVEEQDAYHLLHAQCITFWTHHWGPERVIFGHTAFDAPLVTEYAVGIDTGCVYGHRRTIVIGDLHGCYDEAVELLGKVGATSSDRIIFAGDLVDRGPKRRECVELAMR--HEAILGNHEEKHLQQRHRAD---RVLQPGHYDWMARLPRYLRLNAIVVHAGMLPDIPVEKQDPYHLLHAQCITFWTHHWGPERVIFGHTVFDAPLVTEHAVGIDTGCVYGRGRYIIVGDVHGCVDQLEQLVEKVKYVGKDCLFIIGDYVNKGPDSIGAVRACQRLGAYGVLGNHDYTLLRCCVRMRR--QKLPKDCEYYLRGLPHIVRINVLLVHAGLNLQHSVENQNVEEVMHLRRLEPWAKLWGPEMVIFGHDAYAGFQAHAHACGIDTGCVYGDYRYIIVGDVHGCPEQLEELLLKVEFQGKDCLIHVGDLVNKGPDSLAVVQLVQAKGAIGVLGNHDFTLLNCIARVKG--STFPQGCEDYIRSLPHILRINVIVVHAGLNVENSLEKQNVHEIMHLRRLQPWGELWGPECVVFGHDARAGLQELPFAYGIDTGCVYGGHRYIVVGDVHGCPEQLEQLMLKVNYQGKDCLILAGDLVNKGPDSIGAVRVAQKLGAIGVLGNHDSTLLNCIARCRK--LSFPQGCQDYLRSLPHILRINVIVVHAGLNLNNSIENQDVFEIMHMRRLEPWAEHWGPEFVVFGHDARSGLQEHPFAYGIDTGCVYGSGRLVVVGDIHGCLAQLQGLLRAVSFKGSDTLVAVGDLVNKGPDSFGVVRLLKRLGAHSVLGNHDVKLLKLVKKIRE--LTVPVDVEVYLSQLPHIIRINVIVTHGGLHPQRPLDCQYIDEVTTLRNLVPWASLWGPETVVFGHDSRRGLQERPLAIGLDSGCVYGGGRVIIVGDIHGCRAQLEDLLRAVSFKGSDTLVAVGDLVNKGPDSFGVVRLLKRLGAYSVLGNHDAKLLKLVKKLGK--QSIPTDVETYLSQLPHIIRINVMVAHAGLHPQRPVDRQYEDEVTTMRNLKPWASMWGPETVVFGHDARRGLQEKPLAIGLDSRCVYGGGRVVIVGDIHGCLAQLEDILSVTDFAGRDQLITAGDMVNKGPDSFGVVRLLKSLGARGVIGNHDAKLLKLRKKIRK--MSLPQDVEEYLSQLPHILRIKILVVHAGLHVQHPLERQLVKEVTTMRNLVPWASLWGPETVVFGHDARRGLQRYPHAIGLDTRCVYGGRRTLVVGDVHGCSAELDDLLRAAGFAGRDRLVLLGDLLDRGPDPIGVLRRVRELRAECVLGNHEEKHLRYAAHEARR-AALRRDDLAWLAALPRTIALGWVAVHAGFLPGRPIAAQPPDWMVRLRYVEPWAEVWGPERVVYGHHPQSLVEPDTPALGIDTGCVYGGSRTLVVGDVHGCLGELEDLLAAARYEMRDRLVFLGDLVDRGPDPVGVVRRVRALGADCLLGNHEEKHLRYAAHEARR-LRLSPDDLAWMAALPRALRLGWLAVHGGLLPGRPLSRQPPDWLIRLRFLEPWAERWGPSSVVYGHHARDEVVVDEPAVGIDTGCVYGGSRTLVVGDVHGCLGELEDLLAAARYEMRDRLVFLGDLVDRGPDPVGVVRRVRALGADCLLGNHEEKHLRYAAHEARR-LRLSPDDLAWMAALPRALRLGWVAVHGGLLPGRPLSRQPPDWLIRLRFLEPWAERWGPSSVVYGHHARDEVVVDEPAVGIDTGCVYGGSRTLVVGDVHGCLAELEDLLVAARYEARDRLVFLGDLMDRGPDPVGVVRRVRALGADCLLGNHEEKHLRYAAHEARR-LRLSPDDLAWMAALPRALRLRWLAVHGGLLPGRPLSRQPPDWLIRLRFLEAWAQRWGPSSVVYGHHAREEVVVDEPAVGIDTGCVYGGGRLIVVGDLHG-TPELFTLLERLSFRSHDNLVLVGDLVNKGPASLRLLEALPGLGAVAVRGNHDDAALAAWLAWRQK-RDMSPAQADLLAQLPFTLAVGVAVVHAGLVPGVPLKQQKLWACYKMRNLQAWAPLWGAQHVFFGHDAKRRLQLAPHATGLDTGCVYGGGRLIIVGDVHG-TPELFRLLDSLRYNASDNLILAGDLVNKGPVSLAILDAVPKLGCWAVRGNHDDAVLSAWLQFRA--QDMTDEQAAVLLGLPFTVSVGITVVHAGLVPGVPIEQQDMWAMYKMRNVKAWGALWGPTHVFFGHDAKRRLQLHPHATGLDTGCVYGGKNILVVGDVHGCYNELLELHNKALNEPFQYVILVGDLCNKGPESAKVIRHVRLSNWFSVRGNHDDGALLATLGGR---EALSDDDVQFMADLPYTIKIDTIIVHAGLIPNREIETQEIKTMITIRDLVPWGTAWGPF-VIFGHDAKRKLQMYDNAIGLDTGAVYGGDKILLIGDIHGCLDELKALVSKATDEQFKAIVLVGDLCNKGPYSAQVIEYVRHLHWYAVRGNHDDRALAAAFGDE---KVLTDEDVVWMANLPYTIRIDVIVVHAGLIPNVDLEEQKLKTMLTVRDLIPWVAAWGPELIVFGHDAKRGIQLEEFAIGLDSGCVYGKKGILVIGDVHGCFHELLRLHEKAVQEQFQYVILVGDLCNKGPDSTNVIRHVRAPNWLCVRGNHDDGALAAALGDE---NVLSDEDVLWMANLPYTIRIDTLIVHAGLIPGVLLKDQSIETMITIREVFLWADVWGPERVIFGHDARRGLQQDKWTLGLDTGVVYGKRRIIVVGDIHGCPEELQALLDKVRYRGVDLLVSVGDLVNKGPDSEKVIKLAMESDCLAVRGNHDDSAYEAFRCWLDGKDIPKPKKQGWL---------GVIVVHAGLVPGVPLEQQGMLEMEKMRDVRAWAEVWGPQHVFFGHDAKRRLQLCPAATGLDTGCVYGGKEVLVFGDIHGCFDELQELLHKRKYSSTHVVLSVGDMVNKGPKSLDVLNWFYENGVYTVRGNHDDSMLVTLDKLKEGGNDITTEVHNWATRLPYTIEIDLLIVHAGIVPKLDMDQQTPFDMTRMRFVVQWATTWGPQLIVFGHDAKQGLQEEPFALGLDTGCCYGKDGVYVVGDVHGCRAELEQLLDELGVTEDDLVVFVGDLVRKGPDSAGVVSLVRNDNMFTVRGNNEEKLIRGTKE-----DALSGEQLAWIRNLPVAISWDSLVVHGGVDPRKPLADHTIDELENVRALPYWWEVYGPSRVFFGHTPLSAPVARRHAVGLDTGCVYGNEGIYVVGDVHGCHEELEQLLDELGVTDDDLVVFVGDLVRKGPDSEGVVSLVRNPNMLTVRGNNEEKLIRGDKR-----DELTEEQMEWIRNLPVAISWDAFVVHGGVDPQKPLSEHSIKELETFRKFAYWWEAYGPRRVFFGHTPLSAPVDRRYAVGLDTGCVYGNDDIYIIGDVHGCHDELNQLLSTLDVTDTDLVVFVGDLVRKGPDSKGVLEHVRHENMFTIRGNNEEKLLRGEKS-----PVLSSDDLSWIRSRPVGISWDTLVVHGGVDPRKELSEHTTYELQTFRSLPFWWERYGSDRIFFGHTPLAAPVYRECAIGLDTGCVYGNDDIYVVGDVHGCLSELETLLDELDPSDEDLVVFVGDLIRKGPDNHGVVDLVRSPNMISIRGNNEEKIIKGTKE-----DDLTEEDIDWIRNLPVAISWGALVVHGGVDPRMDLDDHTVDDLQNTRSLPFWWEEYGPAHVFFGHTVMREPAIADYALGLDTGCVYGGDDIYVVGDVHGCLSELETLLDELDPSDEDLVVFVGDLIRKGPDNHGVVDLVRSPNMISIRGNNEEKIIKGTKE-----DDLTEEDIDWIRNLPVAISWGALVVHGGVDPRMDLDDHTVDDLQNTRSLPFWWEEYGPAHVFFGHTVMREPAIADYALGLDTGCVYGGDDVYVVGDVHGCLPALERLVDRLEPSEDDLVVFVGDLVRKGPDSKGVVDYVREDNFLTVRGNNEEKLIRGTKE-----DALTDDDLEWISNLPVAITWDAIVVHGGVHPEKPLSEHSVDELENTRAMPFWFEYYGPERVFFGHTVMAHPAVFEYAMGLDTGAVYGGEDIYVVGDVHGCLPELESLLDDLAPSADDLVVFVGDLIRKGPDSIGVVELVREDNFRSVRGNNEQKLLDGDVE-----DEFGEAEIEYVRSLPAAISWDALVVHGGVDPRKPLSEHSIDDLETTRSLPFWFEEYGPRRVFFGHTVLERPVEREWAVGLDTGCVYGG---------HGCPEPLDRLLSTLEITDDDLVVFVGDLVRKGPDSAGVVERVRDDNMFSVRGNNEEKLLRGDKS-----ASLSDDDLAWIESLPVAITVENLIVHGGVDPRKPLAEHTIDDLQNTRSLPYWYEEYGPPRVFFGHTVLDEPVRSEWAVGLDTGCVYGGEEIYVVGDVHGCRPTLERLLNRLDPTPDELVVFVGDLVRKGPDSAGVVDMVRHPNFLTVRGNNEQKLIDGRKS-----PSLTDDDLSWMASLPVAISWDSLVVHGGVDHRKSIAEHELTELLNMRSLPYWFETRADPRIFFGHTVLSEPFETPTAVGLDTGCVYGGEDIYVVGDVHGCLSALERLVDRIDPDDDTLLVVVGDLIRKGPDSHGVVEFVREDTVVSVRGNNEAKIVRGDKE-----PGLTGEDRAYIESLPHAISWGNLVVHGGVDPRKSLGDHDPAELLTMRSLPFWFEEYDSPRVFFGHTVLAEPYESAGAVGLDTGCVYGGDEVYVVGDVHGCAETLERLLDRLD-NGRSLFVFVGDLVRKGPDSRRALSLVREDNLLSVRGNNEQKLLDGRAS-----DALDDDDLAFVESMPLVVSWGALVVHGGIDHRKPLAEHSAEELLNNRSLPYWFETRGGRTVFFGHTVLAQPFATPWAVGLDTGCVYGGSDIYVVGDVHGSRAALETLLSDLGLNDDDLVIFVGDLVRKGPDSPGVIDLVRESRLISVRGNNEQKVVRGYKD-----EWLRERDRAYFDSLPVVISFDALVVHGGVDPKQTLENHSVEELLTMRAPPFWYESYGPYRVFFGHTVHNRPVEREFAVGLDTGCVYGGDDVYVIGDVHGCLDALEQLLSTLEFGPNDLGVFVGDLVRKGPDSKAVLKRVRDPQLRSVRGNNEQKFLDDEAD-----EALEPADYRYLESLPTAISWDNLVVHGGVDPARSLSEHSDRDLLTMRSPPFWFDEYGPLRVFFGHTVLDEPVEREWAVGLDTGCVYGGDDVYVVGDVHGCPDALERLFSTLEFGSSDLAIFVGDLVRKGPDSKAVLDRVKSPQLRSVRGNNEQKLLDGRAE-----PALDESDRQYIESLPTAISWGNLVVHGGVDPSRPLLEHSNGDLLTMRSPPFWFDEYDGPRVFFGHTVLEEPLERECAVGLDTGCVYGGDEVYVIGDVHGCLDALEALLGTLELGANDLAVFVGDLVRKGPESKAVLDRVRRPRLLSVRGNNERKLLEGEAS-----SALDAVDYQYLESLPTAISWGGLVVHGGLDPSRPLSGHSDDDVLTMRSPPFWFDRYGPPRVFFGHTVLAEPIEREWTVGLDTGCVYGGDSVYVVGDVHGCLDALETLLSTLDLGENDLAIFVGDLVRKGPESEAVVDRIRAPQLMSVRGNNEQKLIDGTAT-----EEFGPSAQAYIESLPVAISWGGLVVHGGIEPSRPFTAHSSEELLTMRAPPFWFDEYGNPRVFFGHTVLEQPLDGERTVGLDTGCVYGG---------HGCRGALDELLATIGVDDDDLVLFVGDLIRKGPDGGSVVRFVRRENMLAVRGNNEQKLLDEEIT-----PSVGPSDRAYLRTLPDAIRWGGLVVHGGLDPEREVYAHTREELQTMRSPPFWFERYGPPRVFFGHTVLSAPIEDEWIVGLDTGCVYGG----------MCIPAVLKLGESASPSGADVCVFVGDLVNKGPDSYGVVRFLRDIGAIGVLGNHDAALLQLSEK-----LHCPDDVFAFMMSVPHILCFRLIVVHAGIDPSIPLAAQSVEAVTRMRNLANWSELWRRIHVVYGHDAKRRLQVYPYAYGLDSGCVYGGRPVVVIGDIHGCFDEFEELLVKIKDESTFQLFLVGDLVNKGPKSAEVVKKVRAGSTHVVRGNHEEALLEEWSTTN---SKLNSDDRLFLLQLPYTISVEWMIVHAGLDPQKSLEHQEPDYMVRMRNFEKWVIKWGEFRVIFGHDARRRLQQGNNYLGLDTGVVYGDRRLVVVGDIHGMLDPFEKLLKKIKFNETDHVIAVGDMINKGPKSSEVIARLMEIKASAVRGNHEDRVILAWRGLSS--RSLTEPQMTWLKRLPVILSAALYFVHAGLVPGVPLPQQDAWAVMNMRTLERWTKMWKEQKVVYGHDAKMGYQEDSYTFGLDSGCVKGNGRIIIVGDVHGHLPELKNLLQKVSYDNGDQLIFVGDLINKGPDSPGVVQLAMDYDALAIRGNNEDRVLAAYSAIKRGQANLSKEQITWLASRPLILRITLIVAHGGLVPHVSLEEQDPWAVMNMRSLLPWIDAWERSIVVYGHDARVGLQVSRYTFGLDSGCVYGRERLIVVGDVQGCMAELDRLLEELLFDTNDHLIFTGNMISQGPNSTDVVDFARKYSASCVRGNNEDRVLVMRHNMIEAQRALSDEQSEWLDACPVILNVQVAVVHGGLIPGVDLNHQDPYSVMNMLTLMMWTKFFGATTVIYGHDSETGLNINTYTKGIDTGCVAGGMATYLIGDVHGCYDELIALLHKVEFTGKDTLWLTGDLVARGPGSLDVLRYVKSDSVRLVLGNHDLHLLAVFAGISRNKAPDADELLNWLRRQPLLQIDKLVMAHAGITPQWDLQTAKECAFTRMRFCKPWFAIPEEYSIAFGHWASLGKGTPEGIYALDTGCCWGGMSTYLIGDVHGCYDELIALLKQVDFTGQDTLWLTGDLVARGPGSLDVLRYVKSDSVRLVLGNHDLHLLAVYAGISRNKAPDADELLNWLRRQPLLQIDKLVMAHAGITPQWDLETAKTCAFTRMRYCKPWFAIPNEYSVVFGHWASLGKGTPENIYALDTGCCWGGMSTYLIGDVHGCFDELQSLLAQVAFDQHDRLWLTGDLVARGPGSLDVLRYVRSPAVRMVLGNHDLHLLAVYAGISRNKAPDADELINWLRRQPVLQVDKLVMAHAGITPQW--------ALTRMRYCKPWFELPADYTIIFGHWASLGKGTPAGVIGLDTGCCWGGMSTYLIGDVHGCFDELMALLAQVSFNAHDRLWFTGDLVARGPASLEVLRYVRSPAAQMVLGNHDLYLLAVYAGISRNKARDVDTLINWLRSQPVMLVDKLVMAHAGVTPQWDLETAQLCAFTRMRYCKPWFYLPPGYAIAFGHWASLGKGTPDNIYALDTGCCWGGMATYLIGDVHGCYHELRALLAQADFDLADTLWLTGDLVARGPDSLDVLRYVKSDCVRLVLGNHDLHLLGIYAGISRNKAPDLDELINWLRRQPMLQVDKLVMAHAGITPQWDLDTAILCALTRMRYCKPWFALPEGYSVAFGHWASLGKGAPRGIYALDTGCCWGGMANLLIGDVHGCYQELRLLLDKANFDDLDTVWFTGDLVARGPDSLQVLRFIKSDKARICLGNHDLHLLAVHANISHLKAPDCDELMHWLRHQPIMQIDKLIMVHAGISPQWDLETAKKCAFTRMRYCKPWFMLPVEYSIAFGHWAALGQGTPDQIYALDTGCCWGGMATYAVGDLQGCLAPLKRLLDRVAFDANDRLWLVGDLVNRGPQSLETLRYLYSDSLVCVLGNHDLHLLAAGNNIERLKAPDRAQLLDWLRRQKLMHYDNMALVHAGIPPQWTLKKALKCAFTRMRFCKPWFAYKRDTKIIFGHWAALGKCDEPGVFALDTGCVWGGMATYAVGDLQGCLQPLKCLLERVRFDAVDQLWLVGDLVNRGPESLETLRYLYSQSLTCVLGNHDLHLLAAWRNVERLKAPDADQLLDWLRQQKLLHYDGIALVHAGIPPQWTLGKALELALTRMRFCKPWFAHKRHVTIIFGHWAALGQVKEPGVIALDTGCVWGGMARYAIGDIQGCYHSMMHLLAQVDFQGRDSLWLVGDLINRGTGSLEVLRWVYADHVRLVLGNHDLHAIAVAHHIRPPHADDGAALLGWLRQQPLMVLE-FAMLHAGLYPQWTLPEARALALTRMRLLQPWFKVAAQATILFGHWSALGLYQGEGVVALDTGCLWGR-----IGDLQGCYYSFINLLDACGFNKRDRLWLVGDLINRGPHSTAVLRWLKEANVTTVLGNHDLHALAVHEGFAEVHAADRDELFDWIRLQSLAYAE-YLIVHAGLLPQWDAQQARALAMTRLRVCLPWFDIKKKDTLIFGHWSALGLVLRKRLIGLDTGCLWGEMATYAIGDIQGCFTSLTALLNRIEFDARDRLWLVGDLVNRGPDSLQTLRFVRDASAVTVLGNHDLYLLMVAYGSVRARAPDRDALLNWLRTRPLMHLE-FAMVHAGLLPGWTAQRARALAMTRMRFCVPWFEAPADTTVVFGHWSALGLRVEPRLLALDSGCLWGRMATYAIGDIQGCFGPFQQLLRQIEFNGKDTLWLTGDLVNRGPESLQVLRWVFQDRVQIVLGNHDLHLLAVSEGFGKLHAADGKVLLDWLRCQPLMIAE-YAMVHAGLLPEWSIDKALRLAMTRMRFIIPWFEAKSHTPIICGHWSALGLHITEDILSIDSGCLWGG-----------------------------------------------------DRVRTVLGNHDIHLLAVAAGVRKSGAPDSVELITWLRHQPLAIRE-YLIVHAGVLPQWTAEQVTKLALTRLRYCMPWFEVPSDVTVVCGHWSTLGLVMRPNLIALDTGCVWGG----VIGDLQGCAHEAGLLLERIAADEEARVLFVGDLINRGPASLTALRRMKTGRVEALLGNHDLHLLAVAAGVQKTSAPDRDELIAWLRRRPLAMFV-HLLVHAGVPPQWSAEQTMRLALTRMRLCLPWFDVPADVTVVFGHWSALGLVLRPNLVGLDSGCVWGGMALYCIGDIQGCSDALERLLAHIGFSSRDTVYLLGDLVNRGPDSAAVLRRCMRGALRALLGNHDLHLLAAAHGTRRTSAPDRDALLGWLRRQPLARAHRLLMVHAGVLPSWSVDDTLALALTRLRFCLPWFDVPADTLVAFGHWSTLGWLNRPDLLALDTGCVWGGMAIYCVGDIQGCDSAFARLLETIGFSSRDIVYLLGDLVNRGPESAAVLRRCMRDSARALLGNHDLHLMAAAYGVRQPSAPDRAALLAWIAQQPLARQRTLLMVHAGVLPQWSAADTLAYALTRLRFCVPWFDAPRDVVVAFGHWSTLGWMSRADVLGLDTGCVWGGMAMYLIGDIQGCDSALERLTRLIDFSSRDTLYLLGDLVNRGPESADVLRRLMRASARCLLGNHDLHLLAVSYGVRKPGADDAPALLHWLHHQKLALLEKLLMVHAGVLPAWTATKTIALALTRLRYCVPWFDTPAGDAVAFGHWSTLGWLNRPDAFALDSGCVWGG--------------------------------------NRGHDSLGTLRLLRDSAATCLLGNHDLHLLAVAHGIRKAHAPDRAAWIDWLRQRRMALHA-WLMVHAGVPPPWTLNTTLQLALTRTRYVQPWFEHPQGVPIAFGHWSTLGLIQRHDLLALDTGCVWGG-----IGDLQGCYDVTQRLLEKIRFDAQDTLWFCGDLVNRGGQSLETLRLVHSEHSVVVLGNHDLSLLAVGARTEEEQAEDRDELLDWLRLQKLVHVDGWMMVHAGLAPKWTTQMAEKHALTRMRYCYPWFEVPRDLKVVCGHWSALGLTITQGVHAIDTGAVWGG-----IGDLQGCYDVTQRLLEKIRFDAQDTLWFCGDLVNRGGQSLETLRLVHSEHSVVVLGNHDLSLLAVGARTEEEQAEDRDELLDWLRLQKLVHVDGWMMVHAGLAPKWTTQMAEKHALTRMRYCYPWFEVPRDLKIVCGHWSALGLTITQGVHAIDTGAVWGGMSVWAIGDLQGCYDVTQRLLEKIRFDAQDTLWFCGDLVNRGGQSLETLRLVHSEHSVVVLGNHDLSLLAVGSRTEEEQAEDRDELLDWLRLQKLVHVDGWMMVHAGLAPKWTTQMAEKHALTRMRYCYPWFEVPRDLKVVCGHWSALGLTITQGVHAIDTGAVWGGMATYAVGDLHGCYKSLRRLIDKIDFSERDRIWFTGDLVSRGNQSLEVLRYVKSDSAVCVLGNHDISLIASHYGVTKP-ADDREELISWLRQLPLLHSDGYCMAHAGVYPHWSWRQAEQCAFTRMRGCYPWFSLPLPYKVVFGHWSALGYRHNSQVISLDTGCVWGRMSNYVVGDIQGCFRELEALLTQVSFNANDSLWCVGDIVARGPSSRDALRFFYENSVHSVLGNHDLNLMAVLLGYRQPNDSDRYDWLEWLRHQPLMHQLNTVITHAGIYPWWTLKQASQYAFTRMRYCKPWFNFW-ENRVLFGHWAALGETRRQDVIALDTGCVWGQMAVWAVGDIQGCYGAFRKLLEEIDFDKRDKLWLAGDLVNRGDGSLETLEYIYSESVEVVLGNHDLSLIAAYYGIKKS-SPRAKELIDWLRSQKFLHVDGYCMAHAGISPEFDLGMAIRYAFTRMRFCKPWFECEIDLKIIFGHWSTLGFYQDEHVLALDTGCLWGG---YVIGDVQGCFEALKALLKEIQFDDQDFIWFAGDLIARGENSVGALRFIKKGNAATVLGNHDLNLLAVARGIKKLKALESDELIDWLRKQPLCLFPKTILTHAGIPNIWNAEKTAALALTRMRLTQPWFKFEKTHQIVFGHWAALGERINAQIQNVDGGCVWGH---YVIGDVQGCFEALKALLKTIQFDDQDFIWFAGDLVARGENSLGALRFIKKNAAATVLGNHDLTLLAAARGIKAIKAIDSDDLIDWLRKQPLCVFPTTVLTHAGIPTNWTAEQTAALALTRMRLTKPWFEFAQTHKVVFGHWAALGKTISDSIQNVDGGCVWGHMADYIVGDIQGCLSGLKVVLSKVDFAGKDTLYAVGDLIGRGPESLETLGYLHGDSFHTVLGNHDLNLLAIFCGVRRAKSDRFAKYCHWLRQKPLALSLNTLLTHAGLYPKWSFDKALGLSFTRMRFLTPWFSVNTQQRVVFGHWAALGETQNSHFIALDTGFVWGGMAQYVIGDLQGCFKEFKAILATLAFNSQDTLYLVGDIVARGPDSLSCLRFIKDSSVKTTLGNHDLHLISTFLLNKQPNAPDRNELIEYLQARPLALFLNSLVCHAGLSPEWTLAQALKAAFTRMRYFIPWFELPNDLTVIFGHWAALGKTNSNQFQAIDTGCVWGQMADYAIGDLQGCFNEFNALLQRVNFNSKDHLYLVGDIVARGPDSLACLEYLYKNSITVTLGNHDLHLIACYLLNKPPNSTKLPHYIAFLQTQPLALYLNSFISHAGLNPDWSIAQALQHAFTRMRFLTPWFMHPAKQTLIFGHWAALGKTPHNHLLALDTGCVWGGMATYAVGDLQGCFHTFNSLLDKISFNNSDELWLVGDLINRGLNSLEIIHWCYQKNIKLVLGNHDLHFLSVALSNHKVSSPYKRVFTDWLISIPLLHHS-HIMTHAGLLPSWKTSQAIALALTRMRCLKPWFSIPREVALITGHWSAVGFVKHASGYSLDSGCVWGKTATYAMGDLQGCYVPFAALLEQIDFTQTDRLWLAGDLVNRGPDSHAVINQLYADRVQIVLGNHDLYALARWAGITAAKDPHTDDWMEWLRTRSLLHTDGWSMVHAAIHPDWDMASARGHAFTRARYVAPWHERFTSESIICGHWATQGLLVQPRLLALDSGCVWGRMATYVIGDVHGHYTALMRLLDKIHFSGSDELWFLGDLINKGPDSLAVVRFVSQARHKVVMGNHDFSLLVQAAYPSLQMAADGADLLAKMRQWPLMFVDKIIVSHAGLYPNWTVEQALSLHLTRMRFFIPWYELK-GYRCIFGHWAALGLKIRESWACLDDGAAWGGMTTYALGSVNGDYQALMTLLDKIAFNDIDCLWFSGNLAG-GPESLAVLRLVKDKKAVTVLGNAELQLLQRAAGIVEPSAPDREELLKWLRQRGLMHHDNFTLVHAGIPGAWSFSQALTFAYTQMKYCMPWYRQPAHLHILFADDAGFADQPCPGIYPLSS------MAVYAIGDLHGCLDELQRLLALIRFDAADRLYFTGDLISRGPHGLDCMRLVQSAQAVTLLGNHEVRLLALEHGALPASAEDRSSLYQWVRQMPLMVQERAYMVHAGIPAHWSLAQAQALALTRMRLCQPWFAQRAGEKVLYGHWAMAGLQLKQHSLGLDSGCVYGGMSTYIIGDIHGCADELNRLLRKIKFNLYDKLILAGDLVGRGPASEEVIAQLMEDAVVKVLGNHDLKLLATHYGLAAPKSPRAKDYVAWLEDAKFAHWDAVIVVHGGIPLNWPVSQLRKQVLTRVKFVYPWYACRAGYKIVFGHWAALGMTISDYYICCDDGCVWGGPKLAVIGDVHGSAGQLSALLARLP--AGYEPIFVGDFVDRGPDPVAVLDTLIANRFRAVKGNHDDKLFRALKGNPVQVAPWRERLMVWLAELPTVLLFGIAVVHAYWSPTCPPDEHLWGPIYRIR----WWSVWPGIQVVFGHYHMP--VVTPQAVCVDFGAPEG-RGYDLIGDVHGCAHTLDRLLDLLGYR-RRQALFLGDIVDRGPRIREALHRVHAGEALCIMGNHEFNALGWSTPAAPGSDADWRDFLGWFQQLPLFLDARFRMVHAC----WDGELIATLRRAFFRTK--FWVEADEPLLFVGHYWRPAPI-RPNLACLDYSAVMYG-MYDLIGDIHGHATELKALLAKMDYR-ERTVIFLGDFVDRGPEQVETVTIAQNGHALAVMGNHEFNAVAWATEDPQNLSELHHSMIEWFKTLPVYLDLEFRVVHAC----WHPEHLAAIARTNIRTE--WWREDGEKPLFVGHYWMPAPL-NERIACLDYSVATGGMKVDFIGDIHGHAVELASLLIKLGYNEGRKVVFVGDYIDRGLQIRETLEIVKGKTADAVMGNHEYNAILFHAKNKKNGQEELKMYLEWFKNLPLFIETNYRVVHAY----WNKKHIEFLRRDKCRVK--WWHYPDDKPIFFGHYWLP--TLKSNAKCLDYSVAKNG--VDIIGDIHGHADKLEELLLKMDYKDYRKVIFVGDYIDRGPNNLRVLELVRSGNAMALCGNHEHNAICFNTKVDTG-QALYDETIEWFKSLPLFYETSFRVVHAT----WEENAINYLKRTDIRIK--WWLNEFQMPVFFGHYWLKGAPNRNNICCLDYSVA---MIYDVIGDIHGHADKLKGLLDKLGYKPNHRAIFIGDLIDRGPHEIETLQLVFAGVADALMGNHEYNALAYATVDDMAESEAHNYWLTRFYELPLWIETHACFVHAC----WDVDSMAVLKRHRMRVK--WWQQ-TDKPIFVGHYWLPEPL-SPQVVCTDYSVAGQGSVTDIIPDIHGQAEKLRVALRNLGWQPDREIVFLGDFIDRGPENAAVIRIVREGRARAIMGNHELNALHFHTKDPET-APHTKDVLDWMKGLQLFIEAGFRAVHAA----WIQSDVDRLRRRDIRVK--WW--AKEKPVFFGHYWMPVLQ-TENALCLDYSAGKDGDGLIFIGDLHGQYQKLIDLLEQLDFNEFSKLVFMGDLIDNKPEQVETLELVKSGHAYCLLGNHEFNAVCWASAHPLTDSRLHMKWIEWFKTLPLFIDFDVRAVHAC----WDDVAIQRVLRHHIRVR--WWII-QTIPVVIGHYTLPGPL-NAKVACVDYNAAEDGNKYDVIGDVHGYADELEVLLKKLGYQQGRQVIFIGDLIDKGPKIRQVLEIAKSGTALAVLGNHEYNAICYHTMDRSGLESEWKTYLKWFRSLPIYLNLGLNIVHAC----WDEKYIGFLERSRIRTQ--WWLSPNTGLTLVGHYTFKNEAANERIACLDYSGA---SGYDVIGDVHGCASQLEVLLHKLGYE-ERQAIFVGDLIDRGGEQLRVLEVVKAGSALIVMGNHEFNALAYHTEWPVGSGEDRQRCLEWFATIPLWLDLELRVVHAC----WHDDSIGVVERDNARVQ--WWNS-AEIPVFYGHYWRPKHRHTDYTACVDFSAVKGGGRFDFIGDIHAQYEKLTDLLTHCGYI-YGRLVFLGDLIDNKPDHLSLLNHIKDRLAYCVLGNHEFNAIGWSLKKPDG-SRQYHQWIEWFKTLPLFMDFDVRVIHAC----WHQESIDRIRRKNIRVG--WWKAEQDVPVVVGHYTLPYCV-GDKVVCVDFNAAPGKAGYDFIGDIHGQHGKLLQLLHKLGYEEGRIPVFLGDLLDRGPDVRGLVHRVRTDAAFCILGNHEYNFILLHTPDRQG-EEELTGHLHWMKGLPLALDLKCRAIHAC----WDDALLNRVARRNMRAR--WWN-AEAPPVFFGHYWMKAPL-APNLACLDYGAGLGGGKIDVIGDIHGEAGALTTLLDRLGYDDGRRLVFVGDLVDRGPNSVAVCDVVRGGNAQMVLGNHELNLLLGKHKHGNH-EEWRKKTLDFFRSQPVILERDVIVVHAAILP----ESLKALR---------WDDTKGKE------------------GGAGSGCVLGGGPVDIIGDVHGEIGALLSVLDVLGYNEGRRLVFVGDVVDRGPDSVRCLQVVRGGRAQMVLGNHELNLLRGSRKHGNL-EAFREEALSFLRKLPLVLERDCRVVHAC----WDDESISKLRRDVDRNR--WWNKEEEKLVVFGHYWR-------RACCIDYSVGLGTGPLDIVGDIHGEAEALEHLLGHLGYDQGRRLVFVGDFCDRGPDSPGVLARVVPGHALAVLGNHEINLLREDAKDGSG-LCDIPDTLALLERLPIAMERDLRVVHAAWRP----QQIAMARRFVERVA--WWNEYDAQAVVVGHYWRQGPLSGRRVFCVDYS--VGG

Supplemental Figure S3 GDxHG GDxVDRG GNHE HGG

VxFGH LDTG Motif 1 Motif 2

Supplemental Figure S3: Alignment of the phosphatase domain of ALPH protein phosphatases from both Prokaryotes and Eukaryotes. Candidate ALPH phosphatase sequences identified as detailed in Materials and Methods were aligned using MAFFT. The alignment was visualized in GeneDoc and manually edited to remove the extreme N- and C- terminal regions outside the protein phosphatase domain, plus poorly aligned regions, prior to phylogenetic tree inference. Two conserved bacterial-like phosphatase motifs (orange) were identified in addition to the known canonical PPP-family protein phosphatase motifs (blue). Of the two bacterial-like PPP-phosphatase motifs, Motif 1 represents a novel region of conservation. Motif 2 was previously reported (Andreeva and Kutuzov, 2004). The gene identifiers of each sequence used here are located in Supplemental Table S1.

Supplemental Figure S4

CpSLPA6G215 9DELT

EhSLPaLmSLPcTcSLPb LmSLPb

TcSLPaLmSLPaTcSLPc

TbSLPaPmSLPa

MpSLPgOlSLPd

VcSLPcCrSLPc

A5FYZ4 ACICJ

C7JGL0 ACEP3Q5FPF8 GLUOX

G2I4P6 GLUXN

A9HIJ4 GLUDA

C7PBV5 CHIPD

G8XAS9 FLACAA4CIK5 ROBBHA4APQ2 MARSH

E6X796 CELAD

F7UVF4 EEGSY

F2N9L1 CORGP

C7N2D2 SLAHDC7N0S7 SLAHD

A3IN61 9CHROG6H040 9CHROC8W9T6 ATOPD

B8HLS9 CYAP4

B0JIT7 MICANB1WW02 CYAA5

E0UG92 CYAP2

H8MYK0 CORCM

F9YU86 CAPCC

F4KVD8 HALH1

A6L339 BACV8

A6LG58 PARD8A8FSQ7 SHESH

A0KU52 SHESAA6WR58 SHEB8

A0Z563 9GAMMSpSLP

PvxSLPaPchaSLPb

PbSLPa

PvxSLPbPchaSLPa

HcSLPHcalSLP

G0LIG8 HALWCQ18I99 HALWD

TtSLPPutSLP

PiSLPPcapSLP PrSLP

FcSLPEsSLPb

GtSLPaGtSLPc

ZmSLPc

ZmSLPe

CpaSLPbMpSLPeOlSLPb

OtSLPdOrcSLPc

GtSLPdGtSLPe

CrSLPaCocSLPaOtSLPc

BrSLPbMdpSLPe

Eukaryotes

Myxococcales &

γ-Proteobacteria

α-Proteobacteria

Other Bacteria

Outer Myxococcales

Inner Myxococcales

Archaea

F

E D

B C

A

Supplemental Figure S4: Phylogenetic radial tree depicting SLP protein phosphatase distribution and interrelationships across Eukaryotes, Archaea, and Bacteria. A radial depiction of the orthogonal tree presented in Figure 1. Insets highlight key evolutionary nodes depicted within the tree. Sequences from eukaryotic SLP phosphatases (green), α-Proteobacteria (purple), γ-Proteobacteria (blue), Archaea (black) and other bacteria (red) are highlighted. "Inner Myxococcales" and "Outer Myxococcales" are highlighted in orange and are explicitly labeled on the tree. Sequences used in multiple sequence alignment and phylogenetic tree generation are listed in Supplemental Table S1.

Basal Eukaryotic SLP Phosphatases

SLP1, 2 & Other Eukaryotic SLP Phosphatases

Inner Myxococcales

Basal Eukaryotic SLP Phosphatases

Outer Myxococcales

α-proteobacteria

Supplemental Figure S5

0.1

E0TGJ0 PARBH

E8L7W5 9RHIZ

F2IW59 POLGS

G8API0 AZOBR

G7ZAB6 AZOL4

D3NZT3 AZOS1

E3I2B3 RHOVT

H5YEZ7 9BRADA7HLU4 FERNB

H9UCV4 FERPDA9BIC6 PETMO

H2J819 MARPK

Q11UR6 CYTH3

F4B184 KROS4

C7QL34 CYAP0

E0UA25 CYAP2

B0JSQ6 MICAN

B1WQZ5 CYAA5

B8DK70 DESVME1YER6 9DELT

G7Q752 9DELT

Q3A7H2 PELCD

F2RD99 STRVP

E4N448 KITSK

E4NEL1 KITSK

F8JTJ0 STREN

E8UQ78 STREJ

B7HV78 BACC7

Q8YZT4 NOSS1

Q3M5P0 ANAVT

Q8YP31 NOSS1D7E399 NOSA0

B2J0C0 NOSP7

B0C4K2 ACAM1

Q31LV8 SYNE7

D3QFL2 STALH

B9DJA7 STACT

GammataRLF

E8R2G2 ISOPI

F0SP41 PLABD

D5SSG4 PLAL2NgRLPH

BnRLPH

SrRLPH

MpRLPHb

MpRLPH

SmRLPH

PvRLPHPtRLPHc

CsatRLPHbGmRLPHb

MdpRLPHb

AlRLPHc

Other Bacteria 2

Other Bacteria 1

α-Proteo bacteria

Eukaryotes Planctomycetes

Eukaryotic RLPH

Phosphatases

α-proteobacteria

Planctomycetes

D C

F E

B

A

Supplemental Figure S5: Phylogenetic radial tree depicting RLPH protein phosphatase distribution and interrelationships across both Eukaryotes and Bacteria. A radial depiction of the orthogonal tree presented in Figure 2. Insets highlight key evolutionary nodes depicted within the tree. Sequences from eukaryotic ALPH phosphatases (green), α-Proteobacteria (purple), Planctomycetes (blue), and other bacteria (red and black) are highlighted. Sequences used in multiple sequence alignment and phylogenetic tree generation are listed in Supplemental Table S1.

D4GUB7 HALVDE7QTB4 9EURY

NatrialbaHalovivax

Natronorub

I7BUV9 NATSJ

D2RRW5 HALTVHalosimple

G0I0G4 HALHTC7P488 HALMD

Halosarcin

A7HDV6 ANADFQ2ILE6 ANADE

EhALPHcQ097S7 STIAD

CmALPH

EsALPH

FgALPHb

FgALPHa

AnALPH

LmALPHaLmALPHbTbALPHb

TcALPHbTbALPHa

TbALPHcAqALPHOdALPH

CgALPH

BfALPHbSpALPH

LgALPH

IsALPHAmALPHRpALPH CocALPHa

CocALPHb

CvALPHbSaALPH BnALPH

PtALPHb

FcALPH

Q0ALJ2 MARMMPrpE 9PrpE 8

PrpE 2PrpE 1

PrpE 3

PrpE 4

PrpE 7

PrpE 10

PrpE 5

Q7NN25 GLOVIPA3087 10

PA3087 4

PA3087 1

PA3087 3

PA3087 2

PA3087 8

LsPA3087

PA3087 7PA3087 6

PA3087 9

PA3087 5 PscPA3087BnPA3087

A0L5C1 MAGSM

ApaH 2ApaH 7

CarApaH

ApaH 5 ApaH 6ApaH 8

F9ZYF7 METMM

SrApaH AstApaH

HmApaH

XtApaH

PscApaHaHvApaH

PtApaHAaeApaH

RcApaHb

ApaH 10RcApaHaAgApaH

SsApaHb

ApaH 4

ApaH 3OsApaHb

Supplemental Figure S6

Living Archaeal ALPHs

Eukaryotic ALPHs

Ancient Archaeal Ancestor

Eukaryotes

ApaH PA3087

PrpE

Archaea

Inner Myxococcales

Outer Myxococcales

I

H

G

F

E

D

A

C B

Supplemental Figure S6: Phylogenetic radial tree depicting ALPH protein phosphatase distribution and interrelationships across Eukaryotes, Archaea and Bacteria. A radial depiction of the orthogonal tree presented in Figure 3. Insets highlight key evolutionary nodes depicted within the tree. Sequences from eukaryotic ALPH phosphatases (green), Archaea (black), PrpE (pink), PA3087 (red) and ApaH (blue) groups are highlighted. "Outer Myxococcales" and "Inner Myxococcales" are highlighted in orange and are explicitly labeled on the tree. Sequences used in multiple sequence alignment and phylogenetic tree generation are listed in Supplemental Table S1.

Proposed Ancestral Archaeal

ALPH Root

Eukaryotic ALPHs

Outer Myxococcales

Ancient Archeal Ancestor

D3QFL2 STALH

C7JGL0 ACEP3Q5FPF8 GLUOX

G2I4P6 GLUXN

A9HIJ4 GLUDAF0IZ02 ACIMA

Q1D163 MYXXDF8CJ73 MYXFH

A6LG58 PARD8

A6L339 BACV8G8T712 NIAKG

F9YU86 CAPCCF4KVD8 HALH1

B8CJM1 SHEPW

TtSLP

PutSLPPiSLPPsSLP

PrSLP

SpSLPLbSLP

PvxSLPaPchaSLPb

PvxSLPbPchaSLPa

PbSLPb

LmSLPbLmSLPc

TcSLPc

BdSLPbOsSLPb

ZmSLPc

ZmSLPe

ZmSLPdMgSLPc

PperSLPa

OlSLPb

ThalSLPb BrSLPb

MpSLPdA6G215 9DELT

AaSLPaGtSLPa

FcSLPCrSLPc

VcSLPcMpSLPhOlSLPd

E4N448 KITSK

F2RD99 STRVP

E4NEL1 KITSK

B3Q125 RHIE6F7UVF4 EEGSY

F4B184 KROS4A4CIK5 ROBBH

A4APQ2 MARSHC7PBV5 CHIPD

GammataRLF

E8R2G2 ISOPI

F0SP41 PLABD

D5SSG4 PLAL2

NgRLPH

BnRLPH

SrRLPHMpRLPHa

MpRLPHbGmRLPHb

EgRLPHAlRLPHc

PtRLPHb

MdpRLPHb

OsRLPHPscPA3087

PA3087 8

PA3087 2

PA3087 5

PA3087 9

PA3087 6

PA3087 7

PA3087 3

PA3087 4

PA3087 1

PA3087 10

PrpE 8

PrpE 1PrpE 2

PrpE 3

PrpE 4

PrpE 5ApaH 2 PscApaHa

ApaH 10ApaH 5ApaH 6

ApaH 8ApaH 4

A0L5C1 MAGSMSrApaH

HhApaHHalovivax

NatronorubD2RRW5 HALTVI7BUV9 NATSJ

G0LN38 HALWC

B8JET4 ANAD2A9ER55 SORC5

F8CMG1 MYXFHLmALPHb

LmALPHaTbALPHaCtALPHCgALPHSpALPHLgALPHRpALPH

SaALPH

ALPH Phosphatase Region

SLP Phosphatase Region

RLPH Phosphatase Region

Planctomycetes

Inner Myxococcales

Outer Myxococcales

Outer Myxococcales

Inner Myxococcales

Eukaryotic ALPH

Phosphatases

α- Proteobacteria

Eukaryotic SLP Phosphatases

α- Proteobacteria

Eukaryotic RLPH Phosphatases

Archaea

A

B C

Supplemental Figure S7: Phylogenetic radial tree depicting SLP, RLPH and ALPH protein phosphatase distribution and interrelationships across Eukaryotes, Archaea, and Bacteria. A radial depiction of a maximum-likelihood phylogenetic tree (PhyML, 5 random starts) inferred from a combined sequence set composed of all three classes of bacterial-like phosphoprotein phosphatase sequences. The eukaryotic SLP region is colored green, and the associated α-proteobacterial sequence cluster is labeled 'α-Proteobacteria'. The eukaryotic RLPH region is colored yellow, and the associated α-proteobacterial sequence cluster is labeled 'α-Proteobacteria', with branches denoted with purple circles. The eukaryotic ALPH region is colored blue, and the associated archaeal sequence cluster is labeled 'Archaea'. Support for the labeled nodes (aBayes support) is as follows: Node A (0.997) [α-Proteobacteria plus SLP radiation]; Node B (1.00) [α-Proteobacteria plus RLPH radiation]; Node C (0.999) [Archaeal ALPHs plus ALPH radiation]. In the SLP sequence region and the ALPH sequence region, "Outer Myxococcales" and "Inner Myxococcales" are both clearly indicated in orange and red, respectively. In the RLPH sequence region the associated Planctomycetes bacteria are highlighted in green. Sequences used in multiple sequence alignment and phylogenetic tree generation are listed in Supplemental Table S1.

Supplemental Figure S7