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  • Supplemental Figure S1 - Plant physiology · 2013-10-09 · Supplemental Figure S1 . Mglo SLP : Um...
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Supplemental Figure S1 M g l o S L P : U m S L P : P g r a S L P : M l a r p S L P : R g l u S L P : B d e n S L P : T g S L P : C p a r S L P : L b S L P : C n e o S L P : S p S L P : Q 1 D 1 6 3 _ M Y X : F 8 C J 7 3 _ M Y X : Q 0 8 Y 5 3 _ S T I : H 8 M Y K 0 _ C O R : Q 0 2 8 W 8 _ S O L : B 8 K K W 3 _ 9 G A : A 4 A B U 5 _ 9 G A : A 0 Z 5 6 3 _ 9 G A : A l S L P a : A t S L P 1 : C a r S L P a : B r S L P b : T h a l S L P b : A c S L P a : A c S L P b : C p a S L P a : C c S L P b : C s S L P : C s S L P b : G r S L P b : M d p S L P d : P p e r S L P b : M d p S L P e : V v S L P b : M e S L P b : P t S L P a : P t S L P b : P t S L P c : P t S L P d : R c S L P b : M g S L P a : M g S L P b : G m S L P b : G m S L P c : P v u l S L P b : M t S L P b : E g S L P a : E g S L P b : C s a t S L P a : C s a t S L P b : L u S L P c : B d S L P a : P v S L P a : P v S L P b : P v S L P c : S i S L P a : S b S L P a : Z m S L P b : O s S L P a : P p a S L P c : P p a S L P a : S m S L P a : C r S L P a : V c S L P b : C v S L P b : C o c S L P a : M p S L P c : M p S L P d : O l S L P a : O r c S L P a : O t S L P c : M p S L P b : M p S L P f : O l S L P c : O t S L P b : O r c S L P b : A 9 E U H 1 _ S O R : D 0 L Q 6 4 _ H A L : A 6 F X L 1 _ 9 D E : A 6 G 2 1 5 _ 9 D E : A l S L P b : A t S L P 2 : C a r S L P b : T h a l S L P a : B r S L P a : C p a S L P c : C c S L P a : C s S L P a : M e S L P a : R c S L P a : P t S L P e : G r S L P a : C s a t S L P c : G m S L P a : G m S L P d : P v u l S L P a : M t S L P a : M d p S L P a : M d p S L P b : M d p S L P c : P p e r S L P a : L u S L P a : L u S L P b : C p a S L P b : V v S L P a : A c S L P c : M g S L P c : B d S L P b : O s S L P b : P v S L P d : S i S L P b : S b S L P b : Z m S L P a : P p a S L P b : S m S L P b : M p S L P a : M p S L P e : O l S L P b : O t S L P d : O r c S L P c : C o c S L P b : C v S L P a : C r S L P b : V c S L P a : Z m S L P d : Z m S L P f : Z m S L P g : C m S L P : E h S L P a : G t S L P e : G t S L P d : F c S L P : T p S L P : E s S L P a : E s S L P b : G t S L P b : G t S L P c : G t S L P a : C p S L P : A a S L P a : T c S L P a : L m S L P a : T b S L P a : T c S L P c : C r S L P c : V c S L P c : M p S L P g : M p S L P h : O l S L P d : O r c S L P d : O t S L P a : P m S L P a : P m S L P b : Z m S L P c : Z m S L P e : E h S L P b : L m S L P c : T b S L P b : T c S L P b : L m S L P b : F 4 K V D 8 _ H A L : G 8 T 7 1 2 _ N I A : F 9 Y U 8 6 _ C A P : B 8 C J M 1 _ S H E : A 8 F S Q 7 _ S H E : A 0 K U 5 2 _ S H E : A 6 W R 5 8 _ S H E : A 6 L G 5 8 _ P A R : A 6 L 3 3 9 _ B A C : P b S L P a : P y S L P b : P c h a S L P b : P v x S L P a : P b S L P b : P y S L P a : P c h a S L P a : P v x S L P b : C 7 J G L 0 _ A C E : G 2 I 4 P 6 _ G L U : A 9 H I J 4 _ G L U : Q 5 F P F 8 _ G L U : F 0 I Z 0 2 _ A C I : A 5 F Y Z 4 _ A C I : C 8 W 9 T 6 _ A T O : E 6 X 7 9 6 _ C E L : A 4 A P Q 2 _ M A R : A 4 C I K 5 _ R O B : G 8 X A S 9 _ F L A : C 7 P B V 5 _ C H I : B 7 K A Y 7 _ C Y A : B 7 K 0 3 3 _ C Y A : G 6 H 0 4 0 _ 9 C H : G 6 G V E 8 _ 9 C H : A 3 I N 6 1 _ 9 C H : I 4 G U D 1 _ M I C : B 8 H L S 9 _ C Y A : B 1 X J X 5 _ S Y N : B 1 W W 0 2 _ C Y A : E 0 U G 9 2 _ C Y A : Q 3 M 7 X 2 _ A N A : B 0 J I T 7 _ M I C : F 2 N 9 L 1 _ C O R : F 7 U V F 4 _ E E G : C 7 N 2 D 2 _ S L A : C 7 N 0 S 7 _ S L A : P c a p S L P : P i S L P : P s S L P : P r S L P : P u t S L P : T t S L P : * 2 0 * 4 0 * 6 0 * 8 0 * 1 0 0 * 1 2 0 * 1 4 0 * 1 6 0 * 1 8 0 * 2 0 0 * 2 2 0 * 2 4 0 * 2 6 0 H R R I V A L G D I H G D Y E H A T S I L R A A G I L H S W A G G S T I F V S T G D T V D R G D D T I R L Y R L P Q D L R E Q S R R V G G N V I N V L G N H E M M N A - - - - - - - - - - - - - - - M M D - - - W R Y V T P G D M A S F G G P R R Q A M S L H G W L G M E W M Q N V T M N V Q R A S F V H G G I T P A F A I G V D A M N K D A H S L L T K A L W L S - - - - D - G P F W Y R G Y A L D - A C A T A N R A I D A L G - - - - - V S S L I M G H T P H S G - I H A R C H G Q I F I I D T G M S R A G R L S A L E I D S Y A Y S A V Y V P E G S R R T V A V A D L H G D L D H A L N V L S M A S I V S T W I G G H D T L V S T G D I V D R G D D T I A L Y R L P V S L R Q Q A R L A G G E V K N C L G N H E V M N A - - - - - - - - - - - - - - - I G D - - - W R Y V T K A D V E S F G G V R R H A M S D Q G W I G Q E W L H N V T H T I P R V S F V H G G I T P Q Y A L G I D F I N T V G H S L L L K G L W S E - - - - H - G P L W Y R G Y A T D - A C A N A E K A T K S L A - - - - - V N Q L V M G H T P H D G - F V T R C N N T I L L I D T G I S R A G Q Q S A L I I D F D L L T A L Y K A R P S S R I V A V G D L H G D L D H A V R V L R M A G V V D Q W I G G P S I L V Q T G D I V D R G K A T I L L Y K W M D A L R T E A Q A A G G A V V S L L G N H E Y M N A - - - - - - - - - - - - - - - L G D - - - W R Y V T K E D I E T F G S A R R K V M S T Q G W I G K T W E A S V T A R I A G T V F V H G G I T P E Y A L G I S E I N R I G H S L L H R A L Y A E - - - - H - G P L W E R S Y A L E D I C R Q I E I A T Q R L H - - - - - V R R M V M G H T P Q K G - I S S R C G G K I L L I D T G I S S A G P L T A L E I N Y S L I Q E L A D K K K K Q R V V A I G D L H G D L P H A V R V L R L A E L I D K W I G K K T V L V Q T G D I V D R G R D T I V L Y Q L M D R L R N E A K A A G G A V V S L L G N H E Y M N A - - - - - - - - - - - - - - - L G D - - - W R Y V T E E D I E T F G G K R R K L M S S E G W I G E S W L K N T T A R V S A I A F V H G G I T P E Y A I G I S E I N R I G Q S F L N R S L Y S S - - - - H - G P L W E R S Y A L E E I C D Q I E K T I N L L N - - - - - V R R L V M G H T P Q K G - I L G R C Q G K I L L I D T G I S S A G A L S A L E I Q Y T L V H G L Q E G K L R Q R I V A M G D I H G D L P A A T K I L R R A E V V D Q W I G G D T I L V Q T G D I V D R G P D T I A L Y R F F Q S L R P Q A E R A G G A V V S L L G N H E M M N C - - - - - - - - - - - - - - - L G D - - - Y R Y V T K E D I A S F G G E R R E A F L H - G W I G Q E F R A S V T A R V S A I S F V H G G I T P E Y S S P I T D I N R I G H S I L E S L L W S E - - - - R - G P M W N R D W A L E - I C E R V E K A L E V L N - - - - - V R R M V M G H T P Q E G - I L S R C D G K I L L I D T G I S R A G A H S S L S L T Y T L V E A L Y T A G R P S R I I A V G D L H G D L A Q A L K T L K M A R I M N E W I A G S S I F V Q T G D V V D R G P D T I K L Y K M L Y D L K V Q A E E H G G Q V I Q L L G N H E V M N M - - - - - - - - - - - - - - - A E D - - - L R Y V T E G D Y S S F G G H R R K A F D K D G W P G - N Y L R N I T T W V N G T V F F H G G A H P Q W A L G I D G M N L R A H N G L I G R S F G G - - - - S - G P L W F R G Y A E D - I C K Q L D K A L A D M N - - - - - A V R M V V G H T P Q D G S V L R R C N G K L Y V I D V G I S R V G N S A A L E I - - - - - - - - - - - - - G S R I L A V G D L H G D I G N T M L L L Y G A G V V D N W I A G D T L L I Q T G D V V D R G P D G K R I Y D Y F A S L S A Q A T E Q G G K I I Q L L G N H D V M N I - - - - - - - - - - - - - - - C G D - - - F R Y A H P S E T I E F G G A R R R Q F M D G G H Y G - N M L R P L S I K A N G V I F S H A G I P S D F A L G L S K L T Q Q L R E E L A N D C A G S - - - - Q - G P L W T R V Y S M G - I C E E L D K T L G I L D - - - - - S E K M V I G H T V Q S G N I E V Y C G G R L L L I D T G V S R Y D S P R M L E I R D G S - - - - - - - - - K G R V L V I G D I H G D L K S L I T S L F L S G V I N D W I A K N T L L I Q L G D V V D R G S H A L Q I Y K L F N K L K S Q A P S L G S K F V G L L G N H E V M N L - - - - - - - - - - - - - - - C G Q - - - L H Y V T D E D F Q T Y G G R R T F E W S K E G F V G - K Y L R K L A I R V N D S L Y V H A G L L P K Y A L G L D K L D K L S N D L L E G D F F V E - - - - D - G P L W T R D I S L G - A C K L V D E T L Q I L G - - - - - L S R M V V G H T I Q D N R I N I K C D N K L I L A D T G F S E A G K P C M L E I L Y H N - - - - - - - - - T R H I V A V G D L H G D L P N A R K V L Q F S G I T D D W T G D V D F F V Q T G D I I D R G D D T I P L F F W M D K L R S Q A A A V G G T V L S H L G N H E W M N V - - - - - - - - - - - - - - - I G D - - - W R Y V Y P T E I K T F G S V R Q Q M L T T - G R I G R S W A A T T A S R L S A I S F V H G G L S P T Y T L T P S R I N Q I S D S L L A K L Q Y D G - - - - N - G P L W Y R G W A T D - V C A D V D R V L A K T G - - - - - T R R M I M G H T P D K N - I K A R C G G K I I I I D T G I S H A G A L S A L S L Y Y S L V S A I Y Q H R R R Q R L V A V G D L H G D I D N A K K T L Q M A R I I D K W V A S T D I L V Q T G D I V D R G A Y A D D I Y R L M Q S L R G Q A A S Q G G K V V S I L G N H E V M N A - - - - - - - - - - - - - - - I G D - - - W R Y V T K G D I A R F G G T R Q H A L S A E G W L G Q E W L A S T T A L V P T F S F T H G S L R P S Y A L T P A A I N D L G H S L L T K A L Y A E - - - - G - G P L W W R G L A E R - V C E W A K N L K Q K I G - - - - - A R R I I G G H T P N E K - I V A R C N A S V I I I D T G I S S A G V L S A L E I V Y T L V H A I Y E H S R P T V V Y A I G D I H G D F P N A L D V L S A A G V V S E W T A G N A T L V Q T G D V V D R G P D T R K L F R W F N D L H K Q A E K H G G R V V R L L G N H E F M N A - - - - - - - - - - - - - - - K G D - - - W R Y V H P G D K A S Y P E P R I I D W G H S G E I G N L L L S N V T Y K D N T S H F M H A G L S P E W A Y R E E T V N E L G K E L L S H F M W A I - - - - E - G P M W Y R G L A Q L - A C E V A L N V T K T L N - - - - - V N R L V M G H T P Q H G - I V S R C E G R I L L I D T G L C S A G E R A V L R I S Q N D V E A V Y R G K I V E R V V A V G D V H G D V D A L K E V L R L A G L I D R W I G G K T H L V Q T G D V P D R G D Q T R A A F D L L M R L E Q E A L A A G G R V H A L L G N H E A M N M - - - - - - - - - - - - - - - L G D - - - L R Y V N P G E M A S F A D Q H R V A Y S L Q G R Y G - Q W L R A A V V R I N D T L F V H G G V A P G V P G N L A E L N R W V R Q D F F P D H R D A - - - - Q - G P L W F R G Y A L G - A E P A L D A V L K R Y G - - - - - A R R M V M G H T T N D G K V K V R F N G K A L L I D T G L S T G R N L A A L E L R G G K V N A L Y R E G P V E R V V A V G D V H G D V D A L K E V L R L A G I I D R W I G G K T H L V Q T G D I P D R G D Q T R A A F D L L M R L E Q E A L A A G G R V H A L L G N H E A M N M - - - - - - - - - - - - - - - L G D - - - L R Y V S P G E M A S F A D Q H R V A Y S L Q G R Y G - Q W L R A A V V R I N D T L F V H G G V A P G V P T D L S A L N R W V R Q D F F P G Q R N P - - - - Q - G P L W F R G Y A L G - A G P A L D A V L Q R Y G - - - - - A R R M V M G H T T N D G K V K V R F N G K A L L I D T G L S T G R N L A A L E L R G G K V N A L Y R E G P V E R V V A V G D V H G D V E A L K E V L R L A G L I D Q W T G G K T H L V Q T G D I A D R G A R T R E A F E L M M R L E R E A L A A G G R V H L L L G N H E V M N M - - - - - - - - - - - - - - - R G D - - - L R Y V T P E E L A S F A G L H R A A Y G L E G R Y G - R W L R P A V V R I D G T L F L H G G L H P E V P K T L G A L N R W T R Q D L F P D A T D A - - - - K - G P L W F R G Y A Q E - W S Q G L D A V L E R F G - - - - - A R R M V M G H T P T D G R I G V R F G G R A V L I D T G L S T Y R H L A A L E I R G D R L T A L Y P D G R V E R I V A V A D V H G D V D A L K E V L R L A G L I D H W I G G K A H L V Q T G D L P D R G D H T R D A F E L L M R L E T E A R K A G G R V H P L L G N H E L M N M - - - - - - - - - - - - - - - R G D - - - L R Y V T P G E F A S F A D Q H A A A Y A A D G R Y G - K W L R P A V I R I N D T L F L H G G L A P T V P T T L E E V N R W V W Q D L T P G Q V D P - - - - Q - G P V W F R G Y A I D - W D A G L T Q V L E R F S - - - - - A R R M V M G H T P S D G R L S I R F G G R V I V I D T G L S T H R H L A A L E L R G D R L T A L Y P E G R V P R V V A V G D V H G D Y N G F V E V L R S A G V I D H W A G G K T H L V Q T G D V P D R G P D T R K A M D L L M Q L E K E A D K A G G H V H A L V G N H E A M N V - - - - - - - - - - - - - - - Y A D - - - L R Y T T P A E F A A F V D N Q R I A F S S E G K Y G - K W I R N A L V K I N D T I Y L H G G I S P R Y A M T V K Q I N E A V A A E L N D L P M G T - - - - D - S P L W Y R G I A L E - I A A H V D L V L K T N D - - - - - A Q R I V I S H T V T G A - I I E R F G G K V V M I D T G M T A V G H R A C L L L E G D K V Y A I H R G E K I D R V V A I A D L H G D Y Q S Y I T V L E Q A G L V N R W T G G T T H L V Q L G D V P D R G P D T A R I I E H L M K L E T Q A K K A G G K V H A L I G N H E V M N M - - - - - - - - - - - - - - - T G D - - - L R Y V H P G E Y E A L K S R H R Q H W L P N G E F G - A W V A N T V V R I N R S L F V H A G I S P D Y L R S I G D I N D A V R A E L A K P N V D E - - - - R - G P L W Y R G L A L G D V A V E V D A L L K Y F D - - - - - V D R I V V G H T P G G T - V V P R Y D A R V I A A D S G L A Q H G H L A S L L I E G G K V Y T L Q R G Q Q V E R V V A V A D L H G D Y D N Y I T V L R Q A G V I D R W D A G K T H L V Q L G D V P D R G P D S D K I I R H L M K L E E Q A E K A G G K V H P L I G N H E V M N I - - - - - - - - - - - - - - - T G D - - - L R Y V H P G E Y E A L T S R H R Q H W H P E G Q F G - A W V A N T V I R I N R S L F V H G G I G P D Y L A S M E D I N D T V R E E L R A P D E D E - - - - E - G P L W Y R G L I M G E I A A H V D A L M E R F D - - - - - V D R I V M G H T P G G T - V V P R Y H G R V L A A D S G I A E Y G N L A S V L I E N G Q A F T L Q S G E R S E T V I A I G D V H G D H E Q F V K L L Q A T K L I D R W T G G E T H L V Q L G D L P D R G P D T R K T M D L L L E L Q T S S I E Q G G A V T T L I G N H D M M N V - - - - - - - - - - - - - - - M N D - - - L R Y V D P G E Y K A F R S R H R L A W A P T G T Y G - E W V L P T V A V V G D S L F V H G G I S P D Y I M S I E D I N T A V H S A M G E G Y Y D P - - - - L - G P L W F R G W S Q D L N T M A L N S I L N K Y G - - - - - V A R M V V A H T P V P V - V V P R Y D G K I I M V D V G L S Q H H G F S A L K I E N G Q T M A M V G D R W A R R I V A V G D L H G D L G K A R D A L Q M A G V L S Q W I G Q D S V L V Q V G D I L D R G D D E I A I L S L L R S L D G Q A K A N G G A V F Q V N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V D A R A F D E C T D F R S I L F R P G G R L A C E - L A G V I L R V N N W I F C H G G L L P H H V Y G V E R I N R E V S T W M - R S P R G Y - - - - D - S V V W S R L Y S R E T V N K I L H D T L E A V G - - - - - A K A M V V G H T P Q S G - V N C E Y G C S I W R V D V G M S S G S R P E V L E I R G D K A R V I R S N R D A R R I V A V G D L H G D L G K A R D A L Q L A G V L S Q W V G Q D T V L V Q V G D I L D R G D D E I A I L S L L R S L D D Q A K A N G G A V F Q V N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V D A R A F D E C T D F R S V L L R P G G R L A C E - L S G V I L R V N N W L F C H G G L L P H H V Y G I E R I N R E V S T W M - R S P R G Y - - - - D - S V V W S R L Y S R E T V N K I L H D T L E A V G - - - - - A K A M V V G H T P Q S G - V N C E Y G C G I W R V D V G M S S G S R P E V L E I R G D K A R V I R S N R D A R R I I A V G D L H G D L S K A R D A L Q L G G V L S Q W I G Q D T - - - - V G D I L D R G D D E I A I L S L L R S L D V Q A K A N G G A V F Q V N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V D A R A F D E C T D F R S V L F R P G G R L A C E - L A G V V L R I N N W V F C H G G L L P H H V Y G V E R I N R E V S T W M - R S A R G Y - - - - D - S V V W S R L Y S R E T V S K I L R D T L D A V G - - - - - A K A M V V G H T P Q S G - V N C E Y G C G I W R V D V G M S S G S R P E V L E I I G D K A R V I R S N R D S R R I I A V G D L H G D L S K A R D A L Q I A G V L S Q W V G E D T V V V Q V G D I L D R G E D E I A I L S L L R L L D E Q A K A N G G A V F Q V N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V D T R A F D E C I D F R S V L F R P G G R L A C E - L S G V V L R V N N W V F C H G G L L P H H V Y G V E R I N R E V S T W M - K S S R G Q V E S S K - T V K S S S A W I E C V V G K I L R D S L E A V G - - - - - A K A M V V G H T P Q S G - V N C E Y G C G I W R V D V G M S S G S R P E V L E I R G D K A R V I R S N Q D - - - - L A V - - - - - - - - - - - - - - - - - - - - - - - - - S S Q V L V Q V G D I L D R G D D E I A I L S L L R L L D E Q A K A N G G A V F Q V N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V D A R A F D E C T D F R S V L F R P G G R L A C E - L A G V I L R V N D W V F C H G G L L P H H V Y G V E R I N R E V A T W M - R S Y R G Y - - - - D - S V V W S R L Y S R E T V S K I L R D T L E A V G - - - - - A K A M V V G H T P Q S G - V N C E Y G C S I W R V D V G M S S G S R P E V L E I R G D K A R V I R S N Q D G R R I V A V G D L H G D L A Q T R C A L E L A G V L S L W T G E E T V L I Q L G D I L D R G E D E I A I L S L L R S L S N Q A K S K G G A V F Q L N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V D P G A F N E C G D F R S A L L R P G G P L A C E - L A A V V L K V D D W V F C H G G L L P R H V Y G I E R M N R E V S H W M - K G L R G Y - - - - D - S V V W N R L Y S R D L I Q A V L E D T L D A M G - - - - - A K A M V V G H T P Q A G - I N S K Y S S S I W R I D V G M S S G S R P E V L E I I D N E A R V I R S N R Q G R R I V A V G D L H G D L A Q T R C A L E L A G V L S L W T G E E T V L I Q L G D I L D R G E D E I A I L S L L R S L S N Q A K S K G G A V F Q L N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V D P G A F N E C G D F R S A L L R P G G P L A C E - L A A V V L K V D D W V F C H G G L L P R H V Y G I E R M N R E V S H W M - K G L R G Y - - - - D - S V V W N R L Y S R D L I Q A V L E D T L D A M G - - - - - A K A M V V G H T P Q A G - I N S K Y S S S I W R I D V G M S S G S R P E V L E I I D N E A R V I R S N R Q G R R I I A V G D L H G D L D Q A R F A L Q M A G V L S L W T G G E T V L V Q L G D I L D R G E D E I A I L S L L R L L D V Q A K D V G G A V F Q V N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V E A G A F D E C G A F R T A L F R P G G P L A C E - L A S V V L R V N D W V F C H G G L L P N H V Y G I E R M N K E V S S W M - R G F R G Y - - - - D - S V V W N R L Y S R D N I N A I L Q D T L Q A V G - - - - - A K A M V V G H T P Q E G - V N C K Y N C S I W R V D V G M S S G S R P E V L E I S D D K A R V I R S K R E G R R I V A V G D L H G D L D Q A R C A L A M A G V L S L W T G G E S V L I Q L G D V L D R G E D E L A I L S L L R S L D M Q A K A E G G A V F Q V N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V D S G G F D E C S D F R S V L F R P G G P M A C E - L A G V V L K V N D W V F C H G G L L P H H V Y G L E R M N N E V S L W M - K G L R G Y - - - - D - S V V W N R L Y S R D I I N A V L Q D T L R A V G - - - - - A K A M V V G H T P Q A G - A N C E Y N C S I W R I D V G M S S G S R P E V L E I T D N K A R V I S S K R D G R R I V A V G D L H G D L D Q A R C A L E M A G V L S L W T G G E S V L I Q L G D V L D R G E D E L A I L S L L R S L D M Q A K A E G G A V F Q V N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V D S G G F D E C S D F R S V L F R P G G P M A C E - L A G V V L K V N D W V F C H G G L L P H H V Y G L E R M N N E V S L W M - K G L R G Y - - - - D - S V V W N R L Y S R D I I N A V L Q D T L R A V G - - - - - A K A M V V G H T P Q A G - A N C E Y N C S I W R I D V G M S S G S R P E V L E I T D N K A R V I S G K R D G R R I V A V G D L H G D L D Q A R C A L E M A G V L S L W T G G E S V L I Q L G D V L D R G E D E L A I L S L L R S L D M Q A K A E G G A V F Q V N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V D S G G F D E C S D F R S V L F R P G G P M A C E - L A G V V L K V N D W V F C H G G L L P H H V Y G L E R M N N E V S L W M - K G L R G Y - - - - D - S V V W N R L Y S R D I I N A V L Q D T L R A V G - - - - - A K A M V V G H T P Q A G - A N C E Y N C S I W R I D V G M S S G S R P E V L E I T D N K A R V I S G K R D G R R I V A V G D L H G D L D Q A R Y A L E M A G V L S L W T G E D A V L V Q L G D V L D R G D D E I A I L S L L R S L D I Q A K A K G G A V F Q V N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V E S G A F D E C A D F R S V L F R P G G P L A C E - L A A V A L K V N D W I F C H G G L L P H H V Y G I E K M N K E V S Q W M - R G L K G Y - - - - D - S V V W N R L Y S R N I I N A I L Q E T L Q A L G - - - - - A K A M V V G H T P Q S G - A N C E Y N C S I W R I D V G M S S G S R P E V L E I R D D K A R V I R S K R N - - - - M S V G D L H G D L G Q T R C A L E T A G V L S V W I G G E T V L I Q L G D I L D R G E D E I A I L S L L R S L D M Q A K A E G G A V F Q V N G N H E T I N V - - - - - - - - - - - - - - - E G D - - - F R Y V D T G G F D E C L D F R S I L L R P G G P L A R E - L A A V V L K V N D W V F C H G G L V P Q H V Y G V E R M N R E V S D W M - R G L R G Y - - - - D - S V V W N R L Y S R D T I N Y I L Q Q T L Q A V G - - - - - A K G M V V G H T P Q T G - A N C E Y D C S I W R I D V G M S S G S R P E G L S S L N M - - - - - - - - - - G R R I V A V G D L H G D L D Q T R C A L E M A G V L S L W T G G E T V L I Q L G D I L D R G E D E I A I L S L L R S L D I Q A K D E G G A V F Q V N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V E T G G F D E C I D F R S I L L R P G G P L A C E - L A A V V L K V N D W V F C H G G L I P N H V Y G V E R M N R E V S H W M - R G L R G Y - - - - D - S V V W N R L Y S R D T I H S I L E E T L H A V G - - - - - A K A M V V G H T P Q T G - A N C K Y N C S I W R I D V G M S S G S R P E V L E I K D N K A R V I R S K K D Y R S V L C V G D L H G D L G Q T R C A L E T A G V L S V W I G G E T V L I Q L G D I L D R G E D E I A I L S L L R S L D M Q A K A E G G A V F Q V N G N H E T I N V - - - - - - - - - - - - - - - E G D - - - F R Y V D T G G F D E C L D F R S I L L R P G G P L A R E - L A A V V L K V N D W V F C H G G L V P Q H V Y G V E R M N R E V S D W M - R G L R G Y - - - - D - S V V W N R L Y S R D T A N K L H S S T D A T S G - - - - - N G G G A Y S S T Y G K L - V R C E Y D C S I W R I D V G M S S G S R P E V L E I K D N K A R V I R S K K D G R R I V A V G D L H G D L A Q A R C A L E M A G V L S L W T G G D T V L V Q L G D I L D R G E D E I A I L S L L R S L D I Q A K A S G G A V F Q V N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V D S G A F D E C T D F R S I L L R P G G L L A C E - L A A V V L K I D D W V F C H G G L L P H H V Y G I E R M N R E V S H W M - R G L R G Y - - - - D - S V V W N R L Y S R D V I Y S L L E E T L Q A V G - - - - - A K A M V V G H T P Q V G - V N C K Y D C S I W R I D V G M S S G S R P E V L E I R D N T A R V I R S K R D G R R I V A V G D L H G D L D Q A R C A L E M A G V L S L W I G G E T V L I Q L G D I L D R G E D E I A I L S L L R S L D I Q A K A Q G G A V F Q I N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V D S G A F D E C T D F R S I L L T P G G P L A C E - L A S V I L K V N D W I F C H G G L L P Q H V Y G I E R M N S K V S Q W M - K G L K G Y - - - - D - S V V W N R L Y S R D V I L S I L E E T L Q A I G - - - - - A K A M V V G H T P Q A G - V N C K Y N C S V W C V D V G M S S G S R P E V I - - - - - - - - - - - - - - - G R R I V A V G D V H G D L D Q A R C A L E I A G V L S L W T G G E T V L I Q L G D V L D R G E E E I A I L S L L R S L D I Q A K A Q G G A V F Q V N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V D S G A F D E C S D F R S I L L R P G G P L A C E - L A A V V L K I N D W V F C H G G L L P Q H V Y G V E R M N Y E V S H W M - R G L K G F - - - - D - S V V W N R L Y S R D M I Q S V L E E T L Q L L G - - - - - A K A M V V G H T P Q T G - V N C K Y N C S I W C I D V G M S S G S R P E V L E I V E N K A R V I R S K R D G R R I V A V G D V H G D L D Q A R C A L E I A G V L S L W T G G E T V L I Q L G D V L D R G E E E I A I L S L L R S L D I Q A K A Q G G A V F Q V N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V D S G A F D E C S D F R S I L L R P G G P L A C E - L A A V V L K I N D W V F C H G G L L P Q H V Y G V E R M N Y E V S H W M - R G L K G F - - - - D - S V V W N R L Y S R D M I Q S V L E E T L Q L L G - - - - - A K A M V V G H T P Q T G - V N C K Y N C S I W C I D V G M S S G S R P E V L E I V E N K A R V I R S K R D G R R I V A V G D V H G D L D Q A R C A L E I A G V L S L W T G G E T V L I Q L G D V L D R G E E E I A I L S L L R S L D I Q A K A Q G G A V F Q V N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V D S G A F D E C S D F R S I L L R P G G P L A C E - L A A V V L K I N D W V F C H G G L L P Q H V Y G V E R M N Y E V S H W M - R G L K G F - - - - D - S V V W N R L Y S R D M I Q S V L E E T L Q L L G - - - - - A K A M V - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - G R R I V A V G D V H G D L D Q A R C A L E I A G V L S L W T G G E T V L I Q L G D V L D R G E E E I A I L S L L R S L D I Q A K A Q G G A V F Q V N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V D S G A F D E C S D F R S I L L R P G G P L A C E - L A A V V L K I N D W V F C H G G L L P Q H V Y G V E R M N Y E V S H W M - R G L K G F - - - - D - S V V W N R L Y S R D M I Q S V L E E T L Q L L G - - - - - A K A M V V G H T P Q T G - V N C K Y N C S I W C I D V G M S S G S R P E V I - - - - - - - - - - - - - - - G R R I V A V G D L H G D L D Q A R C A L E M A G V L S L W I G G E T V L V Q L G D I L D R G E D E I A I L S L L R S L D I Q A K A E G G A V F Q V N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V D S G A F D E C T D F R S V L L R P G G P L A C E - L A S V I L R I N D W I F C H G G L L P H H V Y G I E R I N R E V S Q W M - K G L R G Y - - - - D - S V V W N R L Y S R D M I L S I L E E T L Q S A G - - - - - A K A M V V G H T P Q A G - V N C K Y N C S V W R I D V G M S S G S R P E V L E I Q N D K A K V I R S R K D G R R I I A V G D L H G D L D K A R Y A L Q M A G I L S L W I G G Q T V L V Q L G D I L D R G E D E I A I L S L L K S L N I Q A K L N G G A V F Q V N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V D S G G F D E C A D F R S V L L R P G G P L A S E - L A A V V L K V N D W I F C H G G L L P H H V Y G I E R I N R E V S Y W M - E G L R G Y - - - - D - S V V W S R L Y S R D T I E S I L R E T L Q A V G - - - - - A K A M V V G H T P Q T G - V N C D F N C S I W R I D V G M S S G S R P E V L E I R E G R A R A I R S K R D G R R I I A V G D L H G D L D K A R Y A L Q M A G I L S L W I G G Q T V L V Q L G D I L D R G E D E I A I L S L L K S L N I Q A K L N G G A V F Q V N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V D S G G F D E C A D F R S V L L R P G G P L A S E - L A A V V L K V N D W I F C H G G L L P H H V Y G I E R I N R E V S Y W M - E G L R G Y - - - - D - S V V W S R L Y S R D T I E S I L R E T L Q A V G - - - - - A K A M V V G H T P Q T G - V N C D F N C S I W R I D V G M S S G S R P E V L E I R E G R A R A I R S K R D G R R I L A V G D L H G D L K Q A R S A L E M A G V L S L W T G G E T V L V Q L G D I L D R G E D E I A I L S L L R S L D K Q A K A K G G A V F Q V N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V D S G G F D E C N D F R S I L F R P G G L L A R E - L A A V V L K V N D W V F C H G G L L P H H V Y G L E R M N K E V S E W M - R G Q R G Y - - - - D - S V V W N R L Y S R D T V C S I L D E T L Q A V G - - - - - A K A M V V G H T P Q I G - V N C K Y N C S I W R V D V G M S S G S R P E V L E I I D D K A R V I R C K R D G R R I L A V G D L H G D L K Q A R S A L E M A G V L S L W T G G E T V L V Q L G D I L D R G E D E I A I L S M L R S L D R Q A K E K G G A V F Q V N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - Y R Y V E S G G F D E C N D F R S I L F R P G G L L A R E - L A A V V L K V N D W V F C H G G L L P H H V Y G L E R M N K E V S E W M - R G Q R G Y - - - - D - S V V W N R L Y S R D T V C S I L D E T M Q A V G - - - - - A K A M V V G H T P Q I G - V N C K Y N C S I W R V D V G M S S G S K P E V L E I I D D K A R V I R C K R D G R R I L A V G D L H G D L K Q A R S A L E M A G V L S L W T G G E T V L V Q L G D I L D R G E D E I A I L S L L R S L D K Q A K A K G G A V F Q V N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V D S G G F D E S N D F R S V L F R P G G L L A R E - L A A V V L K V N D W V F C H G G L L P H H V Y G L E R M N K E V S E W M - K G Q R G Y - - - - D - S V V W N R L Y S R D A V C S I L D E T L Q A V G - - - - - A K S M V V G H T P Q T G - V N C K Y N C N I W R I D V G M S S G S R P E V L E I I D N Q A K V I R C K R D G R T I L A V G D L H G D L K Q A R Y A L E M A G V L S L W T G G E N V L I Q L G D I L D R G E D E I A I L S L L R S L D K Q A K S K G G A V F Q V N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V D S G G F D E C S D F R S I L F R P G G P L A C E - L A G V A L K V N D W V F C H G G L L P H H V Y G L E R M N K E V S E W M - R D P R G Y - - - - D - S V V W N R L Y S R D S V C S V L E E T L Q A V D - - - - - A K A M V V G H T P Q I G - V N C K Y N C S I W R V D V G M S S G S R P E V L E I I D D K A R V I R S K T D G R R I V A V G D L H G D L E Q A R R A F Q M A G V L S T W T G K E T V L V Q L G D I L D R G E N E I A I L S L L R S M D K Q A Q E D G G A I F Q I N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V E S G A F E E C A G F R S V L L R P G G P L A C E - L A A V V L K V N D W I F C H G G L L P H H V Y G I E R M N F E V S N W M - R G L R G Y - - - - D - S V V W S R L Y S R D V I Q S I L E E T L Q A V N - - - - - A K A M V V G H T P Q A G - V N C K Y N C S I W R I D V G M S S G S R P E V L E I V D G K A R A I K G R R D G R R I V A V G D L H G D L E Q A R R A F Q M A G V L S T W T G K E T V L V Q L G D I L D R G E N E I A I L S L L R S M D K Q A Q E D G G A I F Q I N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V E S G A F E E C A G F R S V L L R P G G P L A C E - L A A V V L K V N D W I F C H G G L L P H H V Y G I E R M N F E V S N W M - R G L R G Y - - - - D - S V V W S R L Y S R D V I Q S I L E E T L Q A V N - - - - - A K A M V V G H T P Q A G - V N C K Y N C S I W R I D V G M S S G S R P E V L E I V D G K A R A I K G R R D A R R I V A V G D L H G D L K Q T R L A L E M A G V L G L W T G G Q T V L V Q L G D I L D R G E D E I A I L S L L R S L D V Q A R A Q G G A V F Q V N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V D S G A F D E C L N F R S I L F R P G G R L A R E - L A A V V L K V N D W V F C H G G L L P H H V Y G I E R M N R E V S Q W M - K G L R G Y - - - - D - S V V W N R L Y S R D F I N S I L K D T L E A V G - - - - - A K A M V V G H T P Q A G - V N C K Y N C S I W R V D V G M S S G S R P E V L E I R D D K V R V I R S K R D A R R I V A V G D L H G D L K Q T R L A L E M A G V L G L W T G G Q T V L V Q L G D I L D R G E D E I A I L S L L R S L D V Q A R A Q G G A V F Q V N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V D S G A F D E C L N F R S I L F R P G G R L A R E - L A A V V L K V N D W V F C H G G L L P H H V Y G I E R M N R E V S Q W M - K G L R G Y - - - - D - S V V W N R L Y S R D F I N S I L K D T L E A V G - - - - - A K A M V V G H T P Q A G - V N C K Y N C S I W R V D V G M S S G S R P E V L E I R D D K V R V I R S K R D G R R I V A V G D L H G D L D Q T R S A L R I A G V L S R W T G G Q T V L V Q L G D V L D R G G G E I A I L S L L R S L D V Q A R L Q G G A V F Q I N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V D S T G F D E C L D F R S T L L R P G G A L A C E - L A G V L L K I N D W V F C H G G I L P H H V H G V E R M N R E V S Q W M - K G L R G Y - - - - D - S V V W N R L Y S Q D L I E A A L Y D T L G S L D - - - - - A K G M V V G H T P Q R G - A N C E C N G R I W R V D V G M S K G S R P E V L E I N E S K T R V L R L G R D G R R I V A V G D L H G D L Y Q T R A A L V M A G V L S L W T G G Q T V L V Q V G D I L D R G E D E I A I L S L L S S L N M Q A K S Q G G A V F Q V N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V D P G S F D E C M R Y R A S L L K Q G G P L A C E - L A P V V L V V N D W I F C H G G L L P H H V Y G L E R I N K D V S N W M - Q G S R G Y - - - - D - S V V W T R F Y S Q D S S S L V A E Q T L K S V G - - - - - A K G M V V G H T P Q R G - V N C K C D G K V W C V D V G M S Y G S R P E V L E I I N D R A R V I K D R R G G R R I V A I G D A H G D L S Q T R A A L V L A G V L S V W T G G R T V L V Q V G D I L D R G E D E I A I L S L L S S L S V Q A K S Q G G A V F Q V N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V Y P G G F D E C I R F R S S L F K R G G P L A C E - L A P V V L K I N D W I F C H G G L L P H H V Y G I E R M N I E V S T W M - K S S R G Y - - - - D - S V V W S R M Y S Q D S S S I I A E E T L K S V G - - - - - A K G M V V G H T P Q R G - V N C K C D G K V W C I D V G M S Y G S R P E V L E I V N D R P R V L K K R R D G R R I V A I G D A H G D L S Q T R A A L V L A G V L S V W T G G R T V L V Q V G D I L D R G E D E I A I L S L L S S L S V Q A K S Q G G A V F Q V N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V Y P G G F D E C I R F R S S L F K R G G P L A C E - L A P V V L K I N D W I F C H G G L L P H H V Y G I E R M N I E V S T W M - K S S R G Y - - - - D - S V V W S R M Y S Q D S S S I I A E E T L K S V G - - - - - A K G M V V G H T P Q R G - V N C K C D G K V W C I D V G M S Y G S R P E V L E I V N D R P R V L K K R R D G R R I V A I G D V H G D L S Q T R A A L V L A G V L S V W T G G R T V L V Q V G D I L D R G A D E I A I L S L L S S L N V Q A K P Q G G A V F Q V N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V D P G G F D E C M R F R S S L F K R G G P L A C E - L A P V V L K I N D W I F C H G G L L P H H V Y G I G R M N R E V S R W M - K S S R G Y - - - - D - S V V W S R L Y S Q D S S S I V A E E T L E S V R - - - - - A K G M V V G H T P Q H G - V N C K C D G K V W C I D V G M S Y G S R P E V L E I V N D S P R V L K K R R D D R R I V A I G D V H G D L S Q T R A A L V L A G V L S V W T G G R T V L V Q V G D I L D R G K D E I A I L S L L S S L N L Q A K S Q G G A V F Q V N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y V D P G G F D E C I R F R S S L F K R G G P L A C E - L A P V V L K I N D W V F C H G G L L P H H V Y G I E R M N R E V S M W M - K C S R G Y - - - - D - S V V W S R L Y S H D P S S I V A E Q T L K S V G - - - - - A K G M V V G H T P Q G G - V N C K C D G K V W C V D V G M S Y G S R P E V L E I V N D R P R V L K K R R D G R R I V A I G D V H G D L S Q T R A A L V L A G V L S L W T G G R T V L V Q V G D I L D R G E D E I A I L S L L S S L N M Q A K S Q G G A V F Q I N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y C D P G G F D E C V R F R S S L L K R G G P L A C E - L A P V V L K I N D W I F C H G G L L P H H V Y G I E R M N R E V S I W M - K C S R G Y - - - - D - S V V W S R L Y S Q D P S S I V A E Q T L E A V G - - - - - A K G M V V G H T P Q H G - V N C K C D G K V W C V D V G M S S G S R P E V L E I V N D R P K V L K K R R E G R R I V A I G D A H G D L S Q T R A A L V L A G V L S V W T G G R T I L V Q V G D I L D R G E D E I A I L S L L S S L N M Q A K S Q G G A V F Q V N G N H E T M N V - - - - - - - - - - - - - - - E G D - - - F R Y C D P G G F D E C M R F R S S L L K R G G P L A H E - L A P V V L K I N D W I F C H G G L L P H H V Y G I E R M N R E V S M W M - K C S R G Y - - - - D - S V V W S R M Y S Q D P S S I A A E Q T L E A V G - - - - - A K G M V V G H T P Q H G - V T C K C D G K V W C V D V G M S C G S R P E V L E I V N D R P R V L K E R R E G R R I V A V G D L H G D L N Q T R A A L V M A G L L S V W T G G Q T V L V Q V G D I L D R G E D E I A I L S L L S S L N M Q A K S Q G G A V F Q V N G N H E T I N V - - - - - - - - - - - - - - - E G D - - - Y R Y V D P G A F D E C I R F R S S L F K R G G P L A C E - L A P V V L S V N D W I F C H G G L L P H H V Y G I E R M N R E V S V W M - K S S R G Y - - - - D - S V V W S R L Y S Q G P S S V V A E R T L K S V G - - - - - A K G M V V G H T P Q R G - V N - - - - - - - W Y L L - - F S L G - - - - - - - - - - - - - - - - - - - - - D R R I I A I G D L H G D F E R A Q W A L Q L A G V M S R W T G G T T V L V Q I G D V L D R G E D E I T I L S L L A W L G K Q A R S K G G A V F Q I L G N H E T M N V - - - - - - - - - - - - - - - A G D - - - F R Y V A P G G F Q E A E A F R T K L L S P G G P L A R Q - L A G V V L K V N D W L F A H G G V L P H H V Y G L E R M N R E V S L W M - K N I K G F - - - - D - S I V W S R L Y S K E N A C G I L T A A L S A T N - - - - - S R G L I V G H T P Q I G - A N S K C D G R I W R I D V G M S S G A L P E V L E I V D D K V R I L S V A E E N R R I V S I G D L H G D F E R A Q E A L E L A G V L S R W T G G T T I L V Q I G D V L D R G E D E I A I L S L L A L L G R E A R S K G G A V F Q L L G N H E A M N V - - - - - - - - - - - - - - - A G D - - - F R Y V A P G G F L E A E V F R T K L L S P G G P L A T H - L A G V V L K V N D W L F A H G G V L P Y H V Y G L E R M N R E V S L W I - Q K E K G Y - - - - D - S V V W S R L Y S K E N A C G T L A A A L S A T N - - - - - S R G L V V G H T P Q I G - G N S K C D G R V W R I D V G M S S G A L P E V L E I V D D K V R I L C A R E E E R R I V A V G D L H G D L R Q T K R A L R V A G V L S N W T G G T T V L V Q V G D I L D R G P D E I A I L S L L W H L T E Q A R S K G G A V F Q V H G N H E T M N V - - - - - - - - - - - - - - - S H E - - - F N D T P D C G F E D S Q H F R V L L F S P G G P L A L E - L S G V V L K I N D W L F A H G G L L P H H V Y G L E K M N S E V S N W M - K G G K G F - - - - D - S I V W S R L Y S R K T A C A V L Q Q T L D A V K - - - - - A K G L V I G H T P Q N G - A N S E C D G K V W R I D V G M S R G A T P Q V I E I V G D E V K V L S C Q K E T G R I I A I G D L H G D L D K A V E A L K L G R V I S S W V G G D T V V V Q L G D V L D R G D V E I G I I N L L R Y L D T E A R K Q G G A V Y M L N G N H E S L N V - - - - - - - - - - - - - - - C G D - - - F R Y V T P G A F A E S A L Y R Y S L Y K P G G D L A R E - F S P T V L V V N D T V F A H G G L L P T H V Y G I E R L N S E V A A W M - R G D G D A - - - - N - S V M W N R T L S K E R A C N A L K Q A L A K V R - - - - - G K R L V V G H T P Q G G - V N C E C E N Q V W R I D V G M S Y G R P V Q V I E I V P P E V R V I R N T P N T G R I V A I G D L H G D L D K A V E A L K L G R V I R A W V G S D T V V V Q L G D V L D R G D V E I G I I N L L R Y L D S E A R K C G G A V Y M L N G N H E S L N V - - - - - - - - - - - - - - - C G D - - - F R Y V T P G A F A E S A M Y R Y S L F K P G G D L A K E - F A P T V L V V N D T V F A H G G L L P I H V Y G I E R L N S E V A A W M - R G D G D A - - - - N - S V M W N R T L S K E R A C R A L Q Q A L A K V H - - - - - G K R L V V G H T P Q S G - V N C E C E N Q V W R I D V G M S Y G R P V Q V L E I T Q H E V R I I R S T P T T G R I I A I G D I H G D L Q K A L S C L E M A G V L A K W V G G D T V V V Q L G D V L D R G D C E I G S V L L L R E L D R Q A R Q Q G G A V Y M L N G N H E S L N V - - - - - - - - - - - - - - - A G D - - - F R Y V T P G A F F E S A R A R W Y L Y Q P G G A M A R E - L A A T V L V V N D V V F A H G G L L P H H L Y G L Q R I N D E V A E W M - N G A G D S - - - - S - S V Q W N R T F G K E R M N F Q L R A T L E S L N - - - - - A R A M V V G H T P Q S G - V N C E C D G R V W R V D A G M S S G A A P Q V - - - - - - - - - - - - - - - - S G R I I A I G D I H G D V Q K A I T S L K L G G V L V V W C G G N T V V V Q L G D V L D R G D S E I G A I I L L R E L D R Q A R L Q G G A V Y M L N G N H E S L N L - - - - - - - - - - - - - - - L G A A M W R R Y V T P G G F R E S G L V R L H L Y S P G G R L A C E - L A P T V L I I N D T V F A H G G V L P N H V Y G L E R L N A E V A A W M - R G A G G P - - - - D - S V M W N R Q F G H E R A C M D L D A T L R L L G - - - - - A R Q L I V G H T P Q N G - A N C E C N G R V W R M D V G M S K G A A P Q V L E I E P E D I R L L C P P S V K G R V V A L G D V H G D I G Q A R R A L T I A G V L G T W I G G D T V V V Q V G D V L D R G D D E I A I L I L L Q K L H K A A Q A D G G A V Y I L N G N H E V L N V - - - - - - - - - - - - - - - S G D - - - F R Y V T Q G A F Q E S T R F R V G L F S P G G P L A Q Q - L A S T V L I V N D T V F A H G G L M P R H V F G L E K L N N A V A D W M - R G A G S K - - - - D - S V V W N R T F G Q E N A C E T L G K T L D A I D - - - - G A K R L V V G H T P Q G G - C N A E C D G R I W R I D V G M S F G A D P E V I E I V G D E V R V L T S R V P P G R V V A L G D V H G D I G Q A R R A L T I A G V L G E W T G G N T V V V Q V G D V L D R G D D E I A I L I L L Q K L H K Q A E A Q G G A V Y I L N G N H E V L N V - - - - - - - - - - - - - - - S G D - - - F R Y V T Q G A F Q E S A R F R V G L F S P G G P L A Q Q - L A S T V L I V N D T V F A H G G L M P R H V F G L E R L N N A V A D W M - R G A G S K - - - - D - S V V W N R T F G T E N A C E V L G N T L D A I S E K Y G A A K R L V V G H T P Q G G - C N G E C D G R I W R I D V G M S F G A D P E V I E I D G D E V R V L N S R V P - G R V V A I G D L H G D I G Q A R R A L R M A G V L D R W V G G D T T L V Q L G D I L D R G D D E I G I L I L L Q K L D K E A Q K Q G G R V Y V M N G N H E V L N V - - - - - - - - - - - - - - - S G D - - - F R Y V S R G A F G E S T R F R I G L F S P G G P L A Q Q - L S H T V L I V N D T V F A H G G L V P R H V F G L D K L N R A V T D W M - R G K G G R - - - - D - S I V W H R A Y G T E K S C E L L G K T L G M I D - - - - G V S R L V V G H T P Q G G - A N C E C N G Q I W R I D V G M S F G A E P Q V L E I D G D E V R V L S S S S V P G R V I A I G D L H G D I G Q A R R A L R L A G V L G T W V G G D T T V V Q V G D I L D R G D D E I G I L I L L Q K L E K E A R K Q G G G V Y V L N G N H E V L N V - - - - - - - - - - - - - - - S G D - - - F R Y V S R G A F G E T M R F R I G L F S P G G P L A Q Q - M S H T V L I V N D T V F A H G G L V P R H V F G L D K L N R A V T D W M - R G K G G R - - - - D - S I V W H R G Y G T E R S C A L L G E T L G M I D - - - - G A N R L V V G H T P Q G G - A N C E C D G R I W R I D V G M S F G A D P Q V L E I D G Q E V R V L T P T N M F G R T V E V S D L A G A M G Q A R R L P H M R R Y R A A W V G G N A T L V Q L G D I L D R G D D E I G I L I L L Q K L D K E A K K A G G A V Y V M N G N H E V L N I - - - - - - - - - - - - - - - S G D - - - F R Y V T R G A F G E T T R F R I G L F S P G G P L A Q Q - L S H T V L I V N D T V F V H G G L V P R H V Y G L D K L N R A V S D W M - R G K G G R - - - - D - S I V W H R G Y G T E N S C E L L E K T L G M I D - - - - G A N R M V V G H T P Q G G - A N C E C D G K I W R I D X X X X X X A E P Q V L E I D G G D V R V I T S A S S - - - - - - - - - - - - - - - - - M K A L E C A K V M D K W C G G D T V V V Q V G D I L D R G D N E L A I M R K F R A L A K D A R A A G G D F I V I N G N H E I M N V - - - - - - - - - - - - - - - L G D - - - F R Y V T K G A Y G E C A R Y R R A L F L P G G E M A V K - M A P T V L Q V D D T V F A H A G I D E S H V Y G F A R I N A E V S Q W M - A G S L E E - - - - K - G V V W T R E Y G G A D A C R R L E K A L D A T G - - - - - A K R I V I G H T P Q K G - V N S G C G G K V W R A D V G A S R G N T P Q V I E I V N G R V R V L S A - - - G R R L V A V G D I H G D F A Q A M K A L E L S K C M N K W I G G T T V L V Q V G D I L D R G D N E L A I M R K F Q K L A K E A K E A G G D V V V M N G N H E I M N V - - - - - - - - - - - - - - - M G D - - - F R Y V T K G A F G E C R R W R R D L F L P G G E M A V K - M A P T V L Q V G D T V F A H A G I T E N H V Y G F Q R L N N E V A A W M - V G K L E E - - - - K - G V V W T R D Y G G A E A C K R L T E A L D A T G - - - - - A K R L I V G H T P Q K G - I N S G C G G K V W R S D T G M S R G N T P Q V I E I V N G R V R I L - - - - - G R R L I A I G D L H G D F L A M V K S L E L A Q V I D K W N G G D A V V V Q V G D V L D R G D S E I A I L R K L R S L A K Q A K E A G G D L I T M N G N H E I M N V - - - - - - - - - - - - - - - M G D - - - F R Y A T P G A F E E C R R Y R Q Q L F K P G G E I A K W - L A P T V L V V D D T V F A H A G I D L S H V Y G F E R I N K E V A M W M - E G K L E S - - - - D - G V V W T R D Y G G K D S C R R L A S A L E G A D - - - - - A K R L V I G H T P Q T G - V T S G C K G T V W R V D V G A S R G N S A Q V I E I I G G K V R V L A - - - - G R R L V A V G D L H G D F L A A V R A L E L A G V M D K W V G G D A V V V Q V G D V L D R G D S E I A I M R K L R A L R K Q A R Q V G G D V V C M N G N H E I M N V - - - - - - - - - - - - - - - M G D - - - F R Y A T P G A F E E C R R Y R Q Q L F K P G G E L A M W - L A P T V L V V D D T V F A H A G I D L S H V Y G F E R I N K E V S M W M - Q G K L E S - - - - D - G V V W T R D Y G G K D A C R K L N T A L D A A G - - - - - A K R L V I G H T P Q T G - V T N G C K G A L W R V D V G A S R G H D V Q V I E I V N G R T R V L A - - - - G R R L I A I G D L H G D F L A M V R S L E L A G V C D K W I G G N A V V V Q V G D V L D R G D S E I A I L R K L R A L K R Q A K E Q G G D V I T M N G N H E I M N V - - - - - - - - - - - - - - - M G D - - - F R Y A T P G A F E E C R L Y R Q K L F S P G G E I A K W - L A P T V L V V D D T V F A H A G I D L S H V Y G F E R I N R E V S L W M - Q G K L E S - - - - D - G V V W T R D Y G G K D A C R R L G A A L D A A E - - - - - A K R L V I G H T P Q T G - V T S G C K G A V W R V D V G A S R G N A A Q V I E V I G G R V R V L A - - - - A D R V V A I G D V H G D L A A T R A A L R I A G A I D R W I G G K L V L V Q T G D E L D R G D D E Q T I V D L F D R L A V E A R A A G G A V Y A L N G N H E V M N V - - - - - - - - - - - - - - - Q L D - - - F R Y V T E G G F K D F E D V R A A A F A P G G L Y A R K - L A D V I I A V G D T V F T H G G V L P A H T Y G I S R I N R E V R A W M - E G K A A E - - - - D - S P V W A R L Y S S D P P C A A L D Q T L A A M S - - - - - A K R M V V G H T V Q H G - A T S A C G D K I W R I D V G M A S H G K P A A L E I V G D T V R V L T P E A T P A R V V A I G D L H G D L D A A L R A L S L A G A I A L W T G G D M V L V Q T G D V L D R G D D E Q A I L D L L A R L E R E A R A A G G A V H A L L G N H E T M N A - - - - - - - - - - - - - - - A G D - - - F R Y V T P G G F S D F A D A R A A A F L P G G V Y A E R - L A N T V V V V G D T V F A H G G V V P R W A Y G I E R V N A E L R C W L - A G E L A E - - - - D - N P M W S R D F S R E P A C D A L E R A L A A L D - - - - - A T R M V V G H T P Q D G - I T S A C D G R V W R I D T G M A A H G A V Q A L E L R G D S A R I L S E D E - - - - - - - - - - - - - - - - - - - - - - - - - - - M D K W I G G S L V I V Q T G D Q L D R G D G E Q A I L E L L A R L Q H E A K A A G G A I H I L N G N H E F M N A - - - - - - - - - - - - - - - M G D - - - L R Y V T P G G L V D F A D A R V A A F L P G R P W A K E - L G N T V V V V G D T A F V H G G V L P A Y A G D I T T L N R E A R A F L - N G E V D P - - - - D - G P V W S R H Y S D E - D C A L L D Q A L A K L E - - - - - V K R M V V G H T V H E G - I Q S A C D E K V W M V D V G M A A H G P T Q V L V I A G A E V S V L A G - - - V P H I I A F G D V H G D F V A M A E V L L G A G I V D H W I A G E T W V V Q V G D Q L D R G Y Q E E E I M N L F E Q L R V E A A E A G G R F L A L N G N H E I M Q A - - - - - - - - - - - - - - - E G R - - - M D Y V F D - - L E A F G G L R V E A F A P G G E W A L V - L A N V I V K V G R T V F V H G G A L P E H A L G I E N M N D A A K A W L - V G D D G S - - - - G - S I V W D R T Y S D D D R C E L L T A A L A A M D - - - - - A D R I V V A H T I Q P G - I N A I C D D R A W R I D T G M A D Y G P I E A L E I T G D V A S V I Q M E - - P E R L V A V G D L H G D L D K S R E A F K I A G L I D R W T G G S T M V V Q V G D V L D R G G E E L K I L Y F L E K L K R E A E R A G G K V L T M N G N H E I M N I - - - - - - - - - - - - - - - E G D - - - F R Y V T K T G L E E F Q V W R I A A L R P E G P I S K R F L T Q T V A V V G D S V F V H G G L L A E H I Y G L E R I N E E V R G W I - N G L R G G - - - - N - S V V W L R K F S E E M D C A A L E H A L S T I G - - - - - V K R M I M G H T I Q A G - I N G V C N D K A I R I D V G M S K G G L P E V L E I R R - D V R I L T S N P L P E R L V A I G D L H G D L E K S R E A F K I A G L I D R W T G G S T M V V Q V G D V L D R G G E E L K I L Y F L E K L K R E A E R A G G K I L T M N G N H E I M N I - - - - - - - - - - - - - - - E G D - - - F R Y V T K K G L E E F Q I W R I A A L R P D G P I A K R F L T Q T V A V V G D S V F V H G G L L A E H I Y G L E R I N E E V R G W I - N G F R G G - - - - N - S V V W L R K F S E E M D C A A L E H A L S T I G - - - - - V K R M I M G H T I Q A G - I N G V C N D K A I R I D V G M S K G G L P E V L E I R R - D V R I V T S N P L P E R L V A I G D L H G D L E K S K E S F R I A G L I D R W T G G S T V V V Q V G D V L D R G G E E I K I L Y F L E K L K R E A E R S G G K V L T M N G N H E I M N V - - - - - - - - - - - - - - - E G D - - - F R Y V T K K G L E E F Q I W R I A A L R P E G P I A K R F L T Q T V A V V G D S V F V H G G L L A E H I Y G L E R I N E E V K G W I - N G L R G G - - - - N - S V V W L R K F S E E M D C A A L E H A L S T I G - - - - - V K R M I M G H T I Q A G - I N G V C N D K A I R I D V G M S K G G L P E V L E I R R - D V R I V T S N P L P E R L V A I G D L H G D L D K S K E A F R I A G L I D K W T G G S T M V V Q V G D V L D R G G E E L K I L Y F L E K L K R E A E K S G G K I L T M N G N H E I M N V - - - - - - - - - - - - - - - E G D - - - F R Y V T E K G L E E F Q I W R I A A L R P E G P I A K R F L S Q T V A V V G D S L F V H G G L L A E H I Y G L E R I N E E V T C W I - N G L R G G - - - - N - S V V W L R K F S D E M D C S A L E H A L S T I G - - - - - V K R M I M G H T I Q A G - I N G V C D N K A I R I D V G M S K G G L P E V L E I R K - D V R I V T S N P L P D R L V A I G D L H G D L E K S K E A F R I A G L I D R W T G G S T M V V Q V G D V L D R G G D E L K I L Y F L E R L K R E A E R E G G R V V T M N G N H E I M N I - - - - - - - - - - - - - - - E G D - - - F R F V T K E G L E E F R V W R I A A L R P Q G P I A K R F L S Q T V A V V G D S V F V H G G L L A E H V Y G L E R M N E E V T S W I - N G L R G G - - - - N - S V V W L R K F S D E R D C A A L E H A L S T I G - - - - - V R R M I M G H T I Q A G - I N G V C G D K A I R I D V G M S K G G L P E V L E I R K - D V R I V T S N P L P E R L I A I G D L H G D F D K S K Q A F R I A G L I D K W I G G S T T V V Q I G D V L D R G G N E L K I L Y F I E K L K R E A A K T G G K I I T M N G N H E I M N M - - - - - - - - - - - - - - - E G D - - - F R F V T K E G L D E F R V W R I A A L R P E G P I S R R F F T V T V L V V G D S I F V H G G L L P E H V Y G L E R I N Q E V R N W I - N G S R G R - - - - D - G V V W V R R F S R E Q D C S A L E H V L A T V G - - - - - V K R M I M G H T I Q S G - I N G A C N N R A I R I D V G M S S G G L P E V L E I D R - N L Q V L T S N T I V D R L I A I G D L H G D L E K S K Q A L R L A G L I N Q W T G G T A T V V Q I G D V L D R G D D E I K I L Y L L E K L K R E A E K S G G K F I T M N G N H E I M N I - - - - - - - - - - - - - - - E A D - - - F R Y A T E M G L K E F E D W R I A A L R P D G P I A R R F L S T T V L V V G D S V F V H G G L L K Q H V Y G L E R I N R E V R D W I - N G L K G R - - - - H - A V V W L R K F S D E - D C S A L E H A L A T L G - - - - - V K R M I M G H T I Q K G - I N A V C D N R A I R I D V G L S R G G L P E V L E I N G - N L L V L T A N P L V D R L I A I G D L H G D L E K S K Q A L R L A G L I N Q W T G G T A T V V Q I G D V L D R G D D E I K I L Y L L E K L K R E A E K S G G K F I T M N G N H E I M N I - - - - - - - - - - - - - - - E A D - - - F R Y A T E M G L K E F E D W R I A A L R P D G P I A R R F L S T T V L V V G D S V F V H G G L L K Q H V Y G L E R I N R E V R D W I - N G L K G R - - - - H - A V V W L R K F S D E - D C S A L E H A L A T I G - - - - - V K R M I M G H T I Q K G - I N A V C D N R A I R I D V G L S R G G L P E V L E I N G - N L L V L T A N P L P D R L I A I G D L H G D L E K S K Q A L R L A G L I D R W F G G S A T V V Q I G D V L D R G D D E L K I L Y F L E K L K R E A V K S G G N L I T M N G N H E I M N V - - - - - - - - - - - - - - - E G D - - - F R Y M T K L G L E E F T N W R I A A L R P N G P I A N R F L S L T V L V V G D S V F V H G G L L A E H V Y G L A R M N K E V S D W I - T G L R G R - - - - N - A V V W L R K F S D E V D C A A L E H V L A T I G - - - - - V K R M I M G H T I Q A G - I N G V C E N K A I R I D V G M S R G G L P E V L E I N G - N L R V L T S N P L P N R L V A I G D L H G D L E K S K Q A F R L A G L I D R W S G G S A T V V Q I G D V L D R G G E E L K I L Y F L E K L K R E A V K S G G N L I T M N G N H E I M N V - - - - - - - - - - - - - - - E S D - - - F R Y V T K V G L E E F S N W R I A A L R P D G P I A N K F L S V T V L V I G D S V F V H G G L L A K H V Y G L E R M N Q E V R D W I - T G L R G R - - - - E - A V V W L R K F S D E V D C S A L E H V L A T I G - - - - - V K R M I M G H T I Q A G - I N A V C D N R A I R I D V G M S K G G L P E V L E I N G - K L R V L T S N P W P D R L I A I G D L H G D L E K S K Q A L R L A G L I D K W A G G S A T A V Q V G D V L D R G D D E I Q I L Y F L E K L K R E A M K D G G N F I T M N G N H E I M N I - - - - - - - - - - - - - - - E G D - - - F R Y V T K L G L K E F E D W R I A A L R P N G P I A N K F L S V T V L V V G D S I F V H G G L L A Q H V Y G L E R I N E E V R D W I - S G L R G R - - - - N - A V V W L R K Y S D V - D C S M L E H V L A T V G - - - - - V K R M I M G H T I Q D G - I N V A C N N R A V R I D V G M S K G G L P E V L E I N Q - N L R V L T S N P L P N R L V A I G D L H G D L E K S K Q A F R L A G L I D R W C G G S T T V V Q I G D V L D R G G E E L K I L Y F L E K L K R E A V K S G G Q L I T L N G N H E I M N I - - - - - - - - - - - - - - - E G D - - - F R Y V T K K A L E E F D V W R I A A L R P D G P I S R R F L A L T V L V V G D S V F V H G G L L E K H V Y G L Q R I N D E V R D W I - N G L R G R - - - - N - A V V W L R K F S D E F D C S L L E H V L A T I G - - - - - A K R M I M G H T I Q I G - I N G A C D N R A I R I D V G M S K G G L P E V L E I D R - N L R V L T S N P M P D R L I A V G D L H G D L S K S K E A L R L A G L I D R W I G G S A T V V Q I G D V L D R G G D E L K I L Y F L E K L K R E A A K D G G M I I T M N G N H E I M N V - - - - - - - - - - - - - - - E G D - - - F R Y V T K E G L E E F R A W R I A A L H P N G P I S G R F L S T T V L V V G E S V F V H G G L L P G H V Y G L Q R I N E E V R D W I - K G L R R S - - - - N - A V V W L R K F S D E S D C S L L K H V L D T I G - - - - - A K R M I M G H T I Q A G - I N G V C N N Q A I R I D V G M S K G G F P E V L E F V G - N P R I L T S N P Y P P R L V A I G D L H G D L E K S K E A L R L A G L I D R Y T G G S A T V V Q I G D V L D R G G D E L K I L Y F L E K L K R E A A R R G G R I I T M N G N H E I M N V - - - - - - - - - - - - - - - E G D - - - F R F A T L P G V E E F R V W R V A A L R P N G P I A K R F L S V T V L V V G D S I F V H G G L L P Q H T Y G L E K I N E E V R D W V - N G S R G A - - - - D - G L V W V R K F S R G D D C S A L E H V L S T V G - - - - - V K R M V M G H T I Q V G - I N G V C D D K A I R I D V G L S K G G L P E V L E I S G - S L R I L T G N P L P P R L V A I G D L H G D L E K S K E A L R L A G L I D R Y T G G S A T V V Q I G D V L D R G G D E L K I L Y F L E K L K R E A A R R G G R I I T M N G N H E I M N V - - - - - - - - - - - - - - - E G D - - - F R F A T L P G V E E F R V W R V A A L R P N G P I A K R F L S V T V L V V G D S I F V H G G L L P Q H T Y G L E K I N E E V R D W V - N G S R G A - - - - D - G L V W V R K F S R G D D C S A L E H V L S T V G - - - - - V K R M V M G H T I Q V G - I N G V C D D K A I R I D V G L S K G G L P E V L E I S G - S L R I L T G N P L P P R L V A V G D L H G D L E K S K Q A L R L A G L I D R Y I G G S A T V V Q V G D V L D R G G E E L K I L Y F L E K L K R E A A R S G G R I V T M H G N H E I M N V - - - - - - - - - - - - - - - E G D - - - F R F A T E S G V E E F R V W R V A A L R P N G P I A T R F L S V T V L V V G D S I F V H G G L L P E H S Y G L E K I N E E V R D W V - K G L R S A - - - - D - G L L W L R K F S R S K D C S A L E H V L A T V G - - - - - V K R M V M G H S I Q V G - I N G A C D D K A I R I D V G L S K G G L P E V L E I S R - N L R I L T E D P L P S R L I A I G D L H G D L K K S K E A L S I A G L I D N Y T G G S A T V V Q I G D V L D R G G D E I K I L Y L L E K L K R Q A A I H G G N F I T M N G N H E I M N A - - - - - - - - - - - - - - - E G D - - - F R F A T K N G V E E F K V W R V A A L R P N G P I S K R F F T V T V L V V G D S I F V H G G L L K E H V Y G L E K I N G E V S D W Y - K G L R G R - - - - N - A L V W L R K F S D - - D C S S L E H V L S T I G - - - - - V K R M I M G H T I Q E G - I N G V C E N K A I R I D V G M S K G G L P E V L E I D R - - V R I L T S N P L Q D R L V A I G D L H G D L E K T K E S L R L A K L I D K W V G G S T T V V Q I G D V M D R G G D E I K I L Y Y L E K L K R E A A R C G G T V I T M H G N H E I M N V - - - - - - - - - - - - - - - E G D - - - F R F V T R K G L E E F R V W R I A A L R P S G P I S S R F L S V A V L V V G D S V F V H G G L L S Q H V Y G L E K I N E E V R D W I - H G L H G A - - - - N - G V V W L R K F S L G L D C S A L E H V L A T I G - - - - - A K R M I M G H T I Q F G - I N G V C N E R A I R I D V G M S K G G L P E V L E I K G - N M R I L T S N P L Q D R L V A I G D L H G D L E K T K E S L R L A K L V D K W V G G S T T V V Q I G D V L D R G G D E I K I L Y Y L E K L K R E A A R C G G T V I T M H G N H E I M N V - - - - - - - - - - - - - - - E G D - - - F R X V T R K G L D D F R V W R I A A L R P S G P I S S R F L S V A V L V V G D S V F V H G G L L G Q H V Y G L E K I N E E L R E W I - H G L R G A - - - - N - S V V W L R K F S H E Y D C S A L E H V L A T I G - - - - - A K R M I M G H T I Q F G - I N G V C N E R A I R I D V G M S K G G L P E V L E I K G - N L R I L T S N P L Q D R L V A I G D L H G D L E K T K E S L R L A K L V D K W V G G S T T V V Q I G D V L D R G G D E I K I L Y Y L E K L K R E A A R C G G T V I T M H G N H E I M N V - - - - - - - - - - - - - - - X X D - - - F R X V T R K G L D D F R V W R I A A L R P S G P I S S R F L S V A V L V V G D S V F V H G G L L G Q H V Y G L E K I N E E L R E W I - H G L R G A - - - - N - S V V W L R K F S H E Y D C S A L E H V L A T I G - - - - - A K R M I M G H T I Q F G - I N G V C N E R A I R I D V G M S K G G L P E V L E I K G - N L R I L T S N P L Q D R L I A I G D L H G D L E K T K E S L R L A K L I D K W V G G S S T L V Q I G D V F D R G G D E L K I L Y Y L E K L R R E A A R C G G T V I T M H G N H E I M N V - - - - - - - - - - - - - - - E G D - - - F R F A T H K G L D E F R G W R V A A L R P N G P I S S R F L A L T V L V V G D S V F V H G G L L A A H V Y G L E K I N A E V R D W V - H G L R G R - - - - N - A V V W L R N F S H E F D C S A L E H V L S T I G - - - - - A K K M I M G H T I Q F G - I N G V C E E R A I R I D V G M S K G G L P E V L E I N G - N M R I L T S N P L P S R L I A I G D L H G D L D K T K Q A F H L A G L I D R W S G G S S T V V Q V G D V F D R G G D E L K I L Y F L E K L K R E A A K S G G E L I T M N G N H E I M N V - - - - - - - - - - - - - - - E A D - - - F R F V T R S G L Q E F E D W R I A A L R P G G P V S T R F L T Q T V V V V G D S V F V H G G L L S N H V Y G L E R I N D E V R E W L - S G S R G R - - - - D - A V V W L R R F S E E A D C S A L E H V L A T I G - - - - - V K R M I M G H T I Q S G - I N G I C G N K A I R I D V G L S K G G L P E V L E I D G T N L R I L T A N P L P S R L I A I G D L H G D L E K T K Q A F R L A G L I D R W S G G S S T V V Q V G D V F D R G G D E L K I L Y F L E K L K R E A A K S G G E L I T M N G N H E I M N V - - - - - - - - - - - - - - - E A D - - - F R F V T R S G L Q E F E D W R I A A L R P G G P V S T R F L T Q T V V V V G D S V F V H G G L L S N H V Y G L E R I N D E V R E W L - S G S K G R - - - - D - A V V W L R K F S E E A D C S A L E H V L A T I G - - - - - V K R M I M G H T I Q G G - I N G I C E N R A I R I D V G L S K G G L P E V L E I D G T N V R I L T A N P L P D R L I A I G D V H G D L E K T K E A F R I G G L I D R W I G G S T T V V Q V G D V L D R G G E E I Q I L Y F L E K L K R E A A R S G G K I I T M N G N H E L L N V - - - - - - - - - - - - - - - D G N - - - F K F T T A D S L K E F K K W R I A A L R P G G P I T R R F L S A T V L V I G D S I F V H G G L S S K H L Y G L D R I N E E V K D W M - N G L - G E - - - - D - G V V W M R K F S V K K D C S A L E H L L T T V G - - - - - V Q R M I M G H T P Q - R - I N D E C D G K A I R I D V G M S R G R L P E V L E I T R - G L K I L S S S P A P D R L I A V G D L H G D L Q K S K E A L R L A A L I D R W T G R T A T V V Q I G D V L D R G G D E L K I L Y F L E K L K R E A E K S G G T I I T M N G N H E I M N V - - - - - - - - - - - - - - - D G D - - - F R F V T Q A G L D E F R V W R I A A L R P E G P I S V R F L S Q T V V V V G D S V F V H G G L L P K H V Y G L E R I N E E V R D W I - N G L R G K - - - - H - S M V W L R K F S H E L D C S T L E H V L A T I G - - - - - A K R M I M G H T I Q T G - I N G A C G N R A I R I D V E A D R - - - - - - - - - - - - - - - - - - - - - - P N R L V A I G D L H G D L D K S K Q A F K I A G L I H R W I G G N T T V V Q I G D V F D R G D D E L K I L Y F L E K L K R E A L R S G G S I I T M I G N H E I M N I - - - - - - - - - - - - - - - D G D - - - F R Y I T P S G L Q E F K A W R I A A L R P N G P I S T R F L S P T A L V V G D S V F V H G G L L Q D H V Y G L E R I N E E V R D W I - N G L R G R - - - - N - S V V W L R K F S D Q V D C S T L Q H V L A T I G - - - - - A K R M I M G H T I Q M G - I N G V C D N Q A I R I D V G M S K G G L P E V L E I I G - N V R I L T S E K V P S R L I A I G D L H G D L P K A K Q A L R L A G L V G R W S G G S A T V V Q V G D I F D R G G D E I K L L Y F F E K L K R E A A G A G G L V I T M N G N H E I M N V - - - - - - - - - - - - - - - E G D - - - F R F A A R E G F E E F E N W R I A A L R P N G L I S S R F L S Q T V V V V G D S V F A H G G L L Q N H V Y G L D L I N E E V R D W I - L G L R G R - - - - D - S I V W L R S F S N E L D C S M L E H V L E T I G - - - - - V K R M I M G H T I Q N G - I N T V C G N R A V R I D V G M S R L R F P E V L E I G E - N L K V L T S N P L P S R L V A I G D L H G D L A K S L A A L R L A G L L P S W A A G P T L A V Q L G D I L D R G G D E L R L L Y F L R R L S I S A A A Q G G A L L P I L G N H E V M N V - - - - - - - - - - - - - - - A G D - - - Y R F V T P E G L R E F S A W R L A A L R P E G P I A R R F L A P T V L V V G D S V F V H G G L L E A H V Y G I E R I N A E V S D W I - R G G S G R - - - - D - A V V W L R R F S E G F D C Q R L Q G V L G M L G - - - - - T K R M V M G H T I Q E G - I N A V C G A Q A V R V D V G L S R G G L P E V L E I N G G G V R V I T T D P A P T R L V A I G D L H G D L P K S L S A L R L A G L V P S W S A G P T L A V Q L G D I L D R G G D E I R L L Y L I R R L A I S A A G Q G G A L L P I M G N H E V M N V - - - - - - - - - - - - - - - S G D - - - F R F A T P Q G L R E F S A W R L A A L L P D G P I A R R F L A P T V L V V G D S V F V H G G L L E A N V Y G L E R I N A E V S E W I - R G E R G R - - - - D - A V V W L R R F S D G V D C Q R L E G V L G M I G - - - - - A K R M I M G H T I Q E G - I N A V C G A Q A V R V D V G L S R G G L P E V L E I N G G G V R V I T T D P A P S R L V A I G D L H G D L P K S L S A L R L A G L V P S W A A G P T L A V Q L G D I L D R G G D E L R L L Y L L R R L A L S A E A R G G A L L P I L G N H E V M N V - - - - - - - - - - - - - - - S G D - - - F R F A T P Q G L Q E F S A W R L A A L R P D G P I A R R F L A P T V L V V G D S V F V H G G L L E A N V Y G L E R I N A E V S E W I - R G E R G R - - - - D - A V V W L R R F S D G F D C Q K L E G V L G M I G - - - - - A K R M V M G H T I Q V G - I N A V C G A Q A V R V D V G L S K G G L P E V L E I N G G G V R V I T T P P S P S R L V A I G D L H G D L P K S L S A L R L A G L V P S W A A G P T L A V Q L G D I L D R G G D E L R L L Y L L R R L A L S A E A R G G A L L P I L G N H E V M N V - - - - - - - - - - - - - - - S G D - - - F R F A T P Q G F Q E F S A W R L A A L R P D G P I A R R F L A P T V L V V G D S V F V H G G L L E A N V Y G L E R I N A E V S E W I - R G E R G R - - - - D - A V V W L R R F S D G F D C Q R L E G V L G M I G - - - - - A K R M V M G H T I Q V G - I N A V C G A Q A V R V D V G L S R G G L P E V L E I N G G G V R V I T T P P S P S R L V A I G D L H G D L P K S L S A L R L A G L V P S W A A G P T L A V Q L G D I L D R G G D E L R L L Y L L R R L A L S A E A R G G A F L P I L G N H E V M N V - - - - - - - - - - - - - - - S G D - - - F R F A T P Q G L Q E F S A W R L A A L R P D G P I A R R F L A P T V L V V G D S V F V H G G L L E A N V Y G L E R I N A E V S E W I - R G E R G R - - - - D - A V V W L R R F S D G F D C K R L E G V L G M I G - - - - - A R R M V M G H T I Q V G - I N A V C S A Q A V R V D V G L S R G G L P E V L E I N A G G V R V I T T P P S L S R L V A I G D L H G D L P K S L S A L R L A G L V P S W A A G P T L A V Q L G D I L D R G G D E L R L L Y L L R R L S L S A E S R G G A F L P I L G N H E V M N V - - - - - - - - - - - - - - - S G D - - - F R F A T P Q G F Q E F S A W R L A A L R P D G P I A R R F L A P T V L V V G D S V F V H G G L L E A N V Y G L E R I N A E V S E W I - R G E R G R - - - - D - A V V W L R R F S D G F D C K R L E G V L G M I G - - - - - A K R M V M G H T I Q V G - I N A V C S A Q A V R V D V G L S R G G L P E V L E I N A G G V R V I T T P P S P K R L I A V G D I H G D L A K A R A A L H V A E V I D H W I G G E T V V V Q V G D L L D R G G E E I K V I Y L L E K L R G E A Q K V G G N V H I M N G N H E I M N I - - - - - - - - - - - - - - - E G D - - - F R Y A T P L G L D E F Q R W R I A A L R P G G P L A S R F L A P T V L V V G S S V F V H G G L L P V H V H G L E R I N Q E V S E W M - L G T H G G - - - - N - A L V W L R K Y S D V K D C D L L K R C L G S I G - - - - - A K R M V V G H T I Q I G - L N G A C D N K V I R V D V G L S K G G M P Q V L E I R G - D L R I L S S R L P V E R L V A I G D I H G D L A K T R E S L R I A G V V D R W I G G K T V V V Q V G D V L D R G G Q E L K V L Y L L E R L K G E A Q R H G G D L H I M N G N H E V M N I - - - - - - - - - - - - - - - E G D - - - F R Y A T K E A L D E F S A W R Y A A L R P G G P I S S R F L A P T I L I V G S T V F A H G G I L P S H L Y G L E K I N A E V R D W I - Q G R R G K - - - - D - A V V W A R Q Y S I P V D C K L L D E V L T G I G - - - - - A S R M V V G H T I Q F G - I N S A C Q N Q V F R V D V G M S S G T A P E V L E I R H - D V R V L S - - - - V R R L V A V G D L H G D L A K T K E A L V A G G L M D R W S G G T T T A V Q V G D Q L D R G G D E V A I L L L L E R L R K E A R D A G G E L V V M N G N H E T L N V - - - - - - - - - - - - - - - A G R - - - F R Y A T A D G L E D F R R W R L A A L A P G G P M A R R F L A P L V V A V G S T V F A H G G V L P H H V Y G L E R I N K E T S D W V - R G N S G R - - - - E - S V V W A R D Y S M P E D C D V L E A S L S K M G - - - - - M K R V V V G H T I Q H G - V N A A C D G K V L R V D V G M S K G G K P E V L E I L D D G G V F R L S L D E - E R L V A I G D L H G D L N K A T R A F R A G G L I D K W I G G A T V A V Q V G D Q L D R G G D E V A I L Y M L E R L R K E A R D A G G E L I V M N G N H E T L N V - - - - - - - - - - - - - - - A G R - - - F R Y A F E P G I E D F R R W R L A A L A P G G P M A K R F L A P V V V A V G S T L F A H G G V L P H H V Y G L E R I N Q E T S E W I - R G D S G G - - - - R - S V V W A R D Y S W P Q D C G V L R R A L D G L G - - - - - I D R V V V G H T I Q E G - V N A A C D G R V L R V D V G M S E G S E P E V L E I L - - - - - - - - - - - - V E R L V A I G D V H G D L A K T R E A F R A A K L T N E W V G G T T T C V Q V G D Q L D R G K D E V A I L H F L E R L R G E A R A A G G E L V V M N G N H E T L N V - - - - - - - - - - - - - - - S G R - - - Y R Y S L A E G N A D F T R W R W R A L A P G A P L A L R F L A P V V V A I G S T L F V H G G V L P E H V Y G L D T L N E E I S Q W I - K R G Q G R - - - - D - S V V W A R D Y S H V Q D C D L L E E T L R M I G - - - - - V E R V V V G H T I Q H G - I T S A C D G K V I R I D V G M S K G A K P E A L E I L K D G I A K M K L G D D V E R L V A I G D V H G D L S K V R E A F R A A G M T N E W V G G S A T C V Q V G D Q L D R G K D E V A I L H F L E R L R G E A R D A G G E L V V M N G N H E T L N V - - - - - - - - - - - - - - - S G R - - - F R Y S L P E G R A D F A R W R W R A L A P G S P M T M R F L A P V V V A I G S T L F V H G G V L P E H V Y G L D T L N A E I S A W M - Q R G Q G R - - - - D - S L V W A R D Y S H V Q D C D L L K E T L A M I G - - - - - I E R V V V G H T I Q Y G - I T K A C D G Q V I R I D V G M S K G A K P E A L E I L N D G I - - - - - - - - V E R L V A I G D V H G D L D K T R E A F R A A R L T N E W I G G T A T C V Q V G D Q L D R G K D E V A I L H F L E R L R T E A R N A G G E L I V M N G N H E T L N V - - - - - - - - - - - - - - - A G R - - - Y R Y A L T E G S A D F A R W R W R A L A P G A P L T L R F L A P V V V A V G S T L F V H G G I L P E H V Y G L D S L N A E I S T W M - K M G Q G R - - - - D - S L V W A R D Y S H V Q D C D L L K E T L K M I G - - - - - V E R I V V G H T I Q H G - I T S A C D G K V I R V D V G M S K G A K P E A L E I L R D G L T K L K V G A D V P R L V A I G D L H G D L K K A R R A F R L G G L T D R W I G G T T T A V Q V G D Q L D R G N D E V R I L Y F L E R L E R E A E R A G G K L H I L N G N H E T M N V - - - - - - - - - - - - - - - A G R - - - F N Y A T L P G L A D F Y H H S E A L H C S A G A V T A R F L A P I A L Q I G S T V F V H G G V L P Q H A L G L E R I N Q E T R A W M - R G E T G R - - - - Q - A I V W A R E Y S A G A D C A A L E Q V L G R L G - - - - - A E R M V V G H T I Q A G - I N S A C E D R V F R I D V G L S K G G E P Q V - - - - - - - - - - - - - - - - V P R L V A I G D L H G D L R K A R R A F R L A G L I D R W A G G T T T V - - V G D L L D R G D Q E L P L L F F L E R L Q G Q A A A A G G A L H V L N G N H E T M N V - - - - - - - - - - - - - - - A G Q - - - F R Y V T H R G M H S F A D W R I L A L Q P G G E V T R R F L A P V V L Q V G S T L F V H G G V L R Q H V Y G L E R I N R E T Q E W M L K G S S G R - - - - G - A V V W S R H Y S A A A D C G Q L A E V L G R V G - - - - - A Q R M V V G H T I Q G G - I N S A C Q G R V L R I D V G L S R G G S P E V L E I V N - D V R R L S E S Q Q P P R L V A I G D I H G D Y H K A V R A L R L A G L M D R W A G G S T V A V Q V G D I L D R G D H E I R I L I L L E R L A A E A A A A G G R L Y L L N G N H E T M N V - - - - - - - - - - - - - - - M G D - - - H R Y A T P G A N L E F L G F R - - A L M P G S E L A R R F F A P T V L Q L G G N V F V H G G V L P A H V Y G L E K I N S E T Q S W M - L A P R G G - - - - S - A I V W A R A F S A S D D C D T L K S V L E S V G - - - - - A Q R M V V G H T I Q R G - I N S A C E S R V V R V D V G M S H G G P V E V L E V L K - D V L R L R E H T P A D R L V A I G D I H G D Y H K A V R A F R L A G L T D R W S G G S T V A V Q V G D I L D R G D H E I R T L I M L E R L A R E A E A A G G R L Y L L N G N H E T M N V - - - - - - - - - - - - - - - M G D - - - H R Y A T P G A N L E V L G L R - - A L R P G S E I S R R F F A P T V L Q V G D N L F V H G G V L P A H V Y G L E R I N R E T Q S W L - L G G L G G - - - - S - A I V W A R A F S A S D D C E T L Q N V L E S I G - - - - - A R R M V V G H T I Q R G - I N S A C E S R V I R I D V G M S H G F P V E V L E V L K - D V R R L R E H G P - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - C L T V L R P D G P I S R R F M A P T V L V V G D S V F V H G G L L E A N V Y G L E R I N A E V S E W I - R G E R G W - - - - D - I V V W L R R F S D G F D C K R L E G V L G M I G - - - - - A K R M V M G H T I Q V G - I N T V G R G P P P S T S V S V G R G A M A Q T L A T V G - - - R T L P Q R G G - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - R L T A L R P D G P I S R R F L A P T V L V V G D S V F I H G G L L E A N I Y G L E R I N A E V S E W I - R G E R G R - - - - D - T V V W L R R F F D G F D C K R L E G V L G M I G - - - - - A K R M V M G H T I Q V E - I N T V G R G P P P S T S V S V G R G A M A Q T L A T T G - - - R T L P Q R G G - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - R L T A L R P D G P I S R R F L A P T V L V V G D S V F I H G G L L E A N I Y G L E R I N A E V S E W I - R G E R G R - - - - D - T V V W L R R F F D G F D C K R L E G V L G M I G - - - - - A K R M V M G H T I Q V E - I N T V G R G P P P S T S V S V G R G A M A Q T L A T T G - - - R T L P Q R G G V R R L L A L G D V H G D L A S L R K C L S L A N V I N E W I G G D A V V V Q V G D V F D R G D A E R A V L H F L D T L D R Q A R E R G G A V Y R L L G N H E V M N V - - - - - - - - - - - - - - - D L D - - - F R Y V T P G G F A E F R R R R A M A L A P G C P T A R L L A E Q L V L I I G D T L F V H G G L R P D H V Y G L E R L N A E T R A W M E R R A K G S - - - - R - S P V W M R T Y S A P H A C R E L E E T L R R A G - - - - - V R R M V V G H T P Q - - V I N G A C R G R V W R V D T G M S A A G A C E V L E I S E T H I R I F T D H G V P G R V V A L G D L H G D A A A A V T A L T A A G L I D H W S G G D A T L V Q L G D V L D R G G E E F A L W G L L E R L R L E A R S A G G R V V T L L G N H E V L N A - - - - - - - - - - - - - - - L G K A - - A T Y V H P A G H A Q F G D D R C A A F R P G G A L A A R L A D P V V A V V G D S V F A H A S L P R G A T G S L A R L N A E T R A W L - L G E G G R - - - - D - S P V W D R T F S A P G D C E A L R D T L R G L G - - - - - A S R L V V G H T P Q - - R V N G A C G G A V W R C D T G C S R W G P V E A L E I Q G G A V R V L R R G T A P K R I V A V G D L H G D I H A T R Q A L R L A G V L H E W I G G D T F L V Q V G D Q V D R G D D E I Q V M S L L H R L G K Q A R A E G G R V E V L V G N H E L M S A - - - - - - - - - - - - - - - Q G N - - - F R Y A T K G A M R N F Q R W R Y L S L R S G G T F A S K F L A K A I L I V G D T V F V H A G L L H K H F E A I N V L N Q E V A A F L - K G E W G N - - - - D - G I L W T R R F S K I D T C K Q L K K T L N R L N - - - - - V R R M V V G H S V Q D G - I S P A C D A S V W R I D V G M S K G T S P Q V L E I K Q D G V N I L G K S I E P D R L V A I G D L H G D I V A T R R A L R L A E V L H E W V G G K T V V V Q V G D Q L D R G D D E L Q I L S L L R K L A V Q A R Q H E G A L H V L I G N H E I L S - - - - - - - - - - - - - - - - T H T - - - A R Y A T R G A L E N F F R W R Y M A L H P G G M I S R T I L A T T A L I V G Q T L F V H A G I D L D H I E A L K K I N E E V S A F F - R G E S T P - - - - D - S M V W M R R Y G G T H T C A T L N A T L K A L D - - - - - V R R M V I G H T I Q S K T I N S A C D G A V W R V D I G M S S G T E P Q I L E M W K N G V N V K K E A A M N Q R L I C I G D V H G D L W A L Q D F L E I S G V Y D E W I G G N T I V V Q C G D I L D R G V E E L A C Y K L L C K L S Q Q A I H T D G K V I L L V G N H E A M N S - - - - - - - - - - - - - - - M G L - - - F Q Y A I N D L E H E R K I G R W S S Y E P G G L L A T S L L A K V A I R V G R T V C V H A G L R P S H L G G I E G M N K Q F R D W I T L E T - - - - - - - - - G P I W M R D Y S Y P H T T R M I E E T L L L L D - - - - - C D R M I M G H T I Q - - Q I N C V L H G R A W R I D V G A S R G G T P E - I K I K Y R Y - - - - - - - - - N Q R I V S F G D V H G D I T A L R T F L I T A R V L D R W S G G D T I C V Q T G D V L D R G D D E L A C F R L L A T L S R Q A K E S G G A L L L L Y G N H E S L N A - - - - - - - - - - - - - - - A G L - - - F Q Y A N P G G N A E F E S T R W A S F E P G G L L A E N M L G L V A C V V G R T V F V H A G L Q A V H L N G I S K L N M E A R D W I L K D C I G A - - - - S - S P V W M R D Y S Q P N K N P Y A K T M I G T L N - - - - - V Q R M V M G H T P Q - - - I N A A M N G R A W R I D V G A S Q G G T P E V L E I - - - - - - - - - - - - - A E R L V V I G D V H G D I D A F R S C L Q M A D L V D K W A G G E T V V V Q M G D I F D R G D D D L P I Q E W V Y K L A Q E A G R A N G A L Y S V M G N H E M L N A - - - - - - - - - - - - - - - M G D - - - H S M A T R K A F V P F L A L R L A A M R P G G P V A - R L M A A V S M K V G D N L F V H A G L L P E H I G G M E R L N A D T C A W M - L G K W Q P - - - - E - G P L W T R V Y S T P D A R A Q L E E V L R L T G - - - - - T K R M V V G H T P Q A G - I N S A A D G Q V W R V D T G M T A M G R P E A L E I R G E E M T I L T E Y K S - - M I P F I G N R V L D - - A F A E T L L A A G L V D N W A A G E T V L V Q A G D V F D R G D A D L E V E E W L W T L Q E Q A T E S G G A V Y H L L G N H E I M N A - - - - - - - - - - - - - - - M G D - - - H S T A S P N S F K P F Q D L R L A A M A P G G P V S - K M L A S V A M K I G D T L L V H G G L R P V N - F D L E S L N R W T H E W L - V G Q W N R - - - - D - S P V W T R F Y S S P G A E A D L Q K V L D A T G - - - - - T V R M I V G H T P Q A G - I N S A L G G R L W R T D T G M T A M G Q P E A L E I V D G V A T I I T A G G K A E R I I A I G D V H G D V D A L H E C L K V A N L V D N W I G G A A H L V Q V G D I L D R G M E E R R C L Q S L L D L K Q K A A D A G G A V H V L L G N H E V M N V - 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- V A E G A N E V V R V L G N H E V L N L - - - - - - - - - - - - - - - L G M A - - G R Y V T D E D V A E F G G E R R E S W S P G G E I W T I L K D E L V H V Y G G H R F V H G G V M P A L T R S I D E L N E Q A S R M I K N G A L S - - - - - E S S P L W S R V Y A L G - A C P P L L N V L R H Y G - - - - - V A R M V V G H T P S D G R M K V R C G G R A I L A D V A L S R W G H P A A L E M T L V N - - - - - - - - - L K R I V A V A D V H G D R R N L M Q A L E N G R V L V E W V M E G T Q V V Q L G D L V D R G P L G L Q C Y R L M Q D L Y - - V A E G A N E V V R V L G N H E V L N L - - - - - - - - - - - - - - - L G M A - - G R Y V T D E D V A E F G G E R R E S W S P G G E I W T I L K D E L V H V Y G G T L F V H G G V M P A L T R S I D E L N E Q A T R M I R D G A L S - - - - - E S S P L W S R V Y A L G - A C P P L L N V L R H Y G - - - - - V A R M V V G H T P S D G R M K V R C G G R A I L A D V A L S R W G H P A A L E M T L V N - - - - - - - - - P S R L V A I G D L H G D L P K S L S V L R L A G L V P S W P A G P T L A V Q L G D I L N R S D D E L R L L Y L L H R L S L S A E T R G G A F L P I L G N H E V M N V - - - - - - - - - - - - - - - S G D - - - F R F A T P Q G F H D R A V C K L P A F L P G G F L A S N Q T S Q R L I K V - - - L F V H S G L L M K N R S D L E E Y I Q E T G R A G R D G R L S C H L F L D S T T F Y K S E Y A M S K I C S L V K E S T S R K V - - - - - L T Q L E I G H L Q Q S G E I S F G C G G R Y L E V D P V V M E A A K A E L V K L V G K G - - - - - - - - - P S R L V A I G D L H G D L P K S L S A L R L V G L V P S W T A G P T L T V Q L G D I L D R G G D E L R L L Y L L - R L S L S A E T R G G A F L P I L G N H E V K N V - - - - - - - - - - - - - - - S S D - - - F R F A T P Q G F H D R A V N R G G G L D P S R L C A C A G F A G A V L I V S R D F N L H Q A F K F E C A Y A Y T E E N T K P G K Y I - - - - - - T K P R T N N S L I W - - - - - - - - K C D Q V L S - - - - - - - - - - - N N L F G L G Y A I Q - - - - - - - - E R R V E R A S V C V T T - - - - - - - - - - - - - - - - - - - - - - P S S V C A V G D L H G D L Q H A L A A L A L C G A V D S W V G G A M T V V Q T G D V L D R G N N S L G V L R A L W R L Q A E A E A A G G E L V L L L G N H E L M N M - - - - - - - - - - - - - - - Q G K - - - V H Y V H K A E L A A E G G A W K R R M Q P T G D L G A A L L R D A A A V R G G T L F V H A G V R L S V A F G V E R L N E A - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - V G H N I V - - W V S S R C G G T L A L L D V G M S S A G L P A A C D V G E E G Y H G A A T R G P A R R L V A V G D L H G D Y E Q T V S V L R L T R L I D H W I G E D A L L V Q L G D I L D V G P D D I L I V R L L M R L Q Q E A H A K G G D V I E L L G N H E L R N F - - - - - - - - - - - - - - - R G D - - - Y K A V D K A S L A A S G G Q R D V L L S N A T D L G R Y - L R K A V F H Y G P F L F M H G G F S T A T A T S V E Q F N S E L T K A L L N G T E D D V D D V A - N P I L V R S I L T V - K C N A L S K V L D K K G - - - - - I Q S V V V G H V P H P R D F D G L C G G R L I D I D F G M S R W G H V A A L E I E E A T V Q L I E T S T A G R Q I V V V G D L H G D L N Q T L A I L K I T G L V D H W I G G D S F F V Q L G D I F D V G P D D I S I V K L L M K L E K E A Q S V G G D V I E L L G N H E I R N L - - - - - - - - - - - - - - - L G D - - - Y S A V D P G S L A G S G G V R D R L L S N R T S V G M Y - L R K A I F H H N E F L F M H G G L S T A T A T G I H E F N K D L R K A L T N G T E G G G Q E V V - N P I L V R S I L N V - R C K D L I K V L Q N K G - - - - - I K S V V V G H V P H H Q D F K D L C G G H L I A I D F G L S R W G H V A A L Q I D D T T V Q L L E S T V R G R R I V A V G D L H G D L N Q T L S I L H L A G L V N H W I G K D T Y F V Q L G D I L D V G P D D L M I V R L L M R L E K E A Q A E G G D V I Q I L G N H E I R N L - - - - - - - - - - - - - - - L G D - - - F S A V D P V S L A Q S G G K R R E L L S N R T P L G I Y - L R R A I F H H K E F L F M H G G L S T A T G T G V E E F N K A L R D T L I N N T E N E A K K V A - N P I L V R S I L N V - R C S E L E K V L S K K G - - - - - I K S V V V G H V P H T D D F S D L C G G R L I A I D F G L S R W G H V A A L E W D D V S V Q L M E S T G K N Q R I I A I G D L H G D I D R L R S T L R A A N V L E A W R K G T D V V V Q L G N V V G Y G P D A P E M L Q L L S G L K P Q A L A S G G R L I T L S G N Q E L L T L - - - - - - - - - - - - - - - S G V - - - L E Y V H P R Q L N L S A G Y L R Y L Y G P G G R Y G R M M A E L A V A I V S D I V F V H G G L T A A Y A R G V N K L N A E - - - W Y - E G A H D E - - - - E - S P L W D H S V V R A - N C G P L S A G M A A L D - - - - - I N L M V V G H T T M D G K V G T W C A G K L M T I D V A M S R Y G G Y E A F V S F L P M L V L G T A E R V V E K L I A I S D I E G N F E A F R R F L L S H K V I D N W I F G K G H L V C V G D F F D R G A N V T E C L W L I Y D L E E K A K A A G G Y V H F I L G N H E I M N M - - - - - - - - - - - - - - - S N D - - - Y R Y V S P K Y M R N A D L Y Y G N W F K S S T E L G - R W L G N V V E K I G D M I F V H G G L A P D L N K T L I D I N N A M R P F Y F I Q E F D A - - - - N - G P L W N R S Y V M A N P E S D V A E S L R K F G - - - - - G K R I I V G H T L V - - H A K M L Y G G K V I A I D T R H V D P N S T A L F F E D G K L - - - - - - - - - P K Q I F V L S D I E G N F K S L F L L L R N Y K I I D K W S F K D N H L V I L G D C F D R G E E V M E C L W L I Y S L E E R A Q R D G G H V H F I L G N H E I M N M - - - - - - - - - - - - - - - N G D - - - W R Y I H P K Y A I T P S G S A T A L Y D G N S E L W - R W L R N I I E Q I G D I L F V H G G I S E A L L L S V T E I N E L A R P Y Y T R A N N S - - - - - D E S P F W Y R G Y Y R A A S E G Q V D T I L K K F D - - - - - A K M I I T G H T I V - - K V T S F F N G K I I N V D T N H A A G V S E A L F I K G N N F - - - - - - - - - P E K L I A I S D I E G N F D A F C G F L Q K N K I I D N W V F G K G H L V L N G D F V D R G Q H V T P T L W L I Y K L E E Q A L Q Q G G K I H Y V L G N H E I M N F - - - - - - - - - - - - - - - Q G N - - - H K Y A D A K Y I K L A Q I I Y K I L Y S K K S E I G - R W L R N V V T K I G D Y L F V H A G F S P E I L L S L E N I N E I T R K N W D K D L L G - - - - - R K G P F W Y R G L V K S Y N A K D V Q E I L K T Y Q - - - - - A E K I V V G H S I V - - A V S A D Y H G K V I R I D V K H G N E - Q G L L V E N G I E Y - - - - - - - - - I K K V V A L S D V H G Q F D V L I T L L T N Q K I I D N W A F G N G H M V M T G D I F D R G H Q V N E V L W F M Y K L D Q Q A R D A G G M V H L L M G N H E Q M V L - - - - - - - - - - - - - - - G G D - - - L R Y V H K R Y D V A A K L L Y D K L Y G A D T E I G - Q W L R N T I I K I N D V L Y M H G G I S S E W I L T L A R A N K L Y R Q H V D A S K F F G - - - - N - G P T W Y R G Y F S E E T E T E L D T I L N H F D - - - - - V K R I V V G H T S Q - - R I L G L F N N K V I A V D T S I K K G G E L L L L E N K Q L T - - - - - - - - - I K K V V A L S D V H G Q Y D I L I T L L R N Q N I I D N W A F G D G H M V M T G D M F D R G H Q V N E V L W F M Y Q L D Q Q A I E A G G K L H L L M G N H E Q M V M - - - - - - - - - - - - - - - R G D - - - L R Y V H E R Y Q V A A K L L Y D E L Y D K S S E I G - Q W L R H T L V K I N D T L F L H G G I S G E W L L T L D V A N D L Y R K N I D R S K F F G - - - - N - G P T W Y R G Y F K P G D E A E L D K I L S Y F D - - - - - V K H I V V G H T S Q - - R V L G L Y N N K V I A V D S S I K E G G E L L L M E D N T L T - - - - - - - - - A G K I V A L S D V H G Q F D V M I N L L K A H K I I D H W A F G D G H M V M T G D M F D R G H Q V N E V L W F L Y E L D K E A Q A A G G R L H L L M G N H E Q M V F - - - - - - - - - - - - - - - R G D - - - L R Y I N E R Y K T S A E L L Y D A L Y N K D T E I G - R W L R N T L V K I N N L L F M H G G I S P E W V L N I S D A N Q L F R Q H L D D K K F F T - - - - N - G P T W Y R G Y F K D A S E Q E I D Q I L S Y F K - - - - - V D H I I V G H T S Q - - R V L G L Y H N K I I A I D S S I K N G G E L L L I D K D K L T - - - - - - - - - V S K I V A L S D V H G Q F D V M I N L L K A H K I I D H W A F D D G H M V M T G D M F D R G H Q V N E V L W F L Y A L D Q E A Q A A G G R L H L L M G N H E Q M V F - - - - - - - - - - - - - - - R G D - - - L R Y V N E R Y Q V S A D L L Y D A L Y N K D T E I G - Q W L R H S L V K I I N I L F M H G G I S P E W V L H I S E A N Q L F R Q H L D D K K F F T - - - - N - G P T W Y R G Y F K D E K E S D I D S I L S Y F K - - - - - V E H I V V G H T S Q - - Q V L G L Y H N K I I A I D S S I K N G G E L L L I D A G K L S - - - - - - - - - P E K T F V L S D P H A N W S C F A S L L K A G K V I D N W I F G T N Q L V I I G D V F D R G V D V L P I Y W L I Y K L E K E A E D A G G K V T F L I G N H E T M V L - 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K H N I - - - - - - - - - - - - - - - P Q E H L D W L K P H Y L D L G D V W L V H A G V D P K - - L S - - - - - - - - - - - - - - - - - - L E D Q T E E Q F C W I R D Q F H S T - - - - - - - - - - - - T K P Y F P D K L I I V G H T I T - - - - - - - - G V G W L D I D T G A Y H P G W L T G L E L T N K I - - - - - - - - - S Q R R I V I G D V H G H Y E G L I T L L E A I A - - - - - P G G D D Q V Y F L G D L I D R G P H S S Y V I D L V R D - - - - - - - - - N N Y L C L L G N H E Q M L L N I L I S V A T T Q A W L H S G G H A T I A S Y P D Q S I - - - - - - - - - - - - - - - P K E H L E W L R P T Y I D L G D V W L T H A G L D P N - - L P - - - - - - - - - - - - - - - - - - L S E Q T A E Q F C W I R E D F H S I - - - - - - - - - - - - P Q P Y F P D K L V I I G H T I T - - - - - - - - G Q G W L D I D T G A Y H P G W L T G L D I T N N L - - - - - - - - - E P R R I I I G D V H G S F Q T L L R L L N R V A - - - - - P D S E D E V Y F L G D L I D R G Q Q S L E V V D F V I K - - - - - - - - - N N Y Q C L L G N H E Y M L L K A L V S E K W F N G W I E S G G A A T L L S Y - N N N I - - - - - - - - - - - - - - - P A E H I N W F Q P A Y L D L G D I W L V H A G V Q P E - - Y P - - - - - - - - - - - - - - - - - - L E Q Q T N E Q F C W I R N E F H A M - - - - - - - - - - - - T Q P Y F K D K L I I T G H T L T - - - - - - - - G S G W L D I E T G V Y H P G W L T A L D W T N Q L - - - - - - - - - - - - - - - M S D I H G C V D E F E R A L E Q V L P H L - - A E P G S E L L L L G D Y V H G G P A S F A V I D R I M E L Q S R W P - - - D K V V A L R G N H E Q M M L E P G - - - - - - - - - - - - M G D - - - - - - - - - - - - - - - - - - D E R S H A H S E R E Y R A W L R P L Y H V E G H V I F V H A G I D E R A - - - - - - - - - - - - - - - - - - - - - - - - - - - - G D L W R W G T D E T T - - - - - - - - - - - - I G R F E D G W A I V A G H V S T - - - - - - - - G E A H Y Y I D G D V L V S G R I P I L L V D T A E - - - - - - - - - - M L I Y A M S D I H G E K E A F E D A L S V V D F - - - - S R P D T V L V L C G D Y F D S R H E H P E F L T Y M R E F Q E S H E - - - G Q V V A L M G N H E A W L L - - - - - - - - - - - - - - - E H D - - - T P A S D P V F L D D M E E A K E E P L L R D - E K T R R W L S P L Y Y E T D S Q I F V H A G I D E D A - - - - - - - - - - - - - - - - - - - - - - - - - - - - G E Y W K L G V E D W Y - - - - - - - - - - - - T Y G T A F E K D I V A G H V G T - - - - - - - - G E S H F F I D G T T E E S K F V P V L K Y D T E T - - - - - - - - - - M K T Y A M G D I H G C A A A F C E Q L S E L G F F D - - S R C E D V L V L L G D Y V D R G P N S L G V I R E A M R L E R D C P - - - G R V V A L L G N H E D D L L R W L T P I E R L R M W R A A S G G A T L R S F L G P A A Y A E L E D A R A C A R I R C H A D E V R W L C W L F H E T E R Q V F V H A G I D E S L - - - - - - - - - - - - - - - - - - - - - - - - - - - - G V S W G T - S A R D T - - - - - - - - - - - - I R F G T F P K D V I A G H T P T - - - - - - - - G A S H F Y M D G A T F L S G R I P V L V Y D S R D - - - - - - - - - - M R R Y A I S D I H G C I E P L Q A Q F E E L G F F D - - T D C A D E L V L L G D Y V D R G P D S L G V L H A V M A L E Q R A A - - - G R V T V L R G N H D E M F L E W L D P E Y R F R S F R Q M P N L A T M R S F L T D E Q L R Q L D H G T A C H A I R N Y P E V I S W M Q R D Y H E T E R Q I F V H A G I D E S A - - - - - - - - - - - - - - - - - - - - - - - - - - - - G R E W A L G T P R E T - - - - - - - - - - - - T S N A P F Y K D V I C G H T P T - - - - - - - - G P S H I Y I D G M T T A S G V L P L L V W N S E T - - - - - - - - - A L R V A L L T D V E G N W Q Y V R N V V R Q S S C L K - - L R D D C M L V F G G D A G D K G D Q T L Q C Y E Q L V S L K K R Y P - - - D R V V L L V G N R D V N K M R F T N R L K W M L E H T M G Q G D F E R R R D V T D E E V V E S - - - Y M D S V K E G G V L Y E Y L L H S L A F V A H Q T L W V H G G I I N G D - P D V D E L N R Q V Q E W I - - - - - - - - - - - E - H P T W N E K Y V L P D V P L E I S S L L S E S G - - - - - I R R V V I G H T P H - - - - - - - - G E E V I M C D T S Y S D A R A A S E L V V Q P S G - - - - - - - - - S R R V A L L T D V E G N W Q Y V R N V V R Q S S C L Q - - L R D D C M L V F G G D A G D K G D H T L K C Y E Q L V H L K K K H P - - - D R V V L L V G N R D V N K M R L T N R L I W M L E H T M G Q G D F E R R R E V T D D D I A K S - - - Y L D S V E E G G V L R E Y L L H S L A F V A H Q T L F V H G G I I D G D - P D V D K L N S Q V Q E W I - - - - - - - - - - - D - H P T W S E K Y V L P D V P E E I A S L L S E S G - - - - - I R R V I I G H T P H - - - - - - - - G E D V V M C D T S Y S D A C A A S E V V V G P S G - - - - - - - - - S L R V A L L T D V E G N W D Y V R N V A R Q S S C L Q - - L K D D C L L V F G G D A G D K G D H T L K C Y E Q L V R L K K R H P - - - E R V V L L V G N R D V N K M R L T N R L K W M L E H T M G Q G D F E R R R E V T D D A V V K S - - - Y M D S V E E G G V L R D Y L L H S L A F V T H Q T L F V H G G I I N G D - P D V D K L N S Q V R E W I - - - - - - - - - - - E - H P T W N E K Y V L P D V P E E I A S L L S E S G - - - - - I R R V I I G H T P H - - - - - - - - G E D V I M C D T S Y S D A N A A S E L V V E P S G - - - - - - - - - G L R V A L L T D V E G N W E Y V R N V V R Q S A C L K - - L R D G C M L V F G G D A G D K G E H T L K C Y E Q L V D L K K R H P - - - D R V V L L V G N R D V N K M R L T N R L K W M L E H T M G Q G D F E R R R E V S E E D V V K S - - - Y V N S V E D G G V L R E F L L H S L A F I T H Q T L F V H G G I I N G D - P D V D K L N G Q V Q E W I - - - - - - - - - - - E - R P T W S I K Y V L P D L P E E A A S L L S E S G - - - - - I R R V I I G H T P H - - - - - - - - G E G V I M C D T S Y S D A S A A S E L T V E P S G - - - - - - - - - S R H I C F L T D V E G N W N Y V R N F V R Q S T C L R - - L N D D C F L V F G G D A G D K G G E T L K C Y E Q L V R L K K K H P - - - E R V V L L A G N R D V N K M R F T N R L K W I L E H T M G Q G D F E R R R T I S D D A V L Q S - - - F M E S V Q E G G V L R E Y L E L S L A F V A Y N T L F V H G G L I S G A - P D V D K L N R E V R A W I - - - - - - - - - - - D - R P L W T P K Y V L P G L P S D V V Q R L S E S G - - - - - I N R L I V G H T P H - - - - - - - - G A E V V M C D T S Y S D M R A A S E V V L D P N G - - - - - - - - - G R P I G Y V T D V E G N A E Y F C R Y V E E S T V V C - - E A D G A V F V Y G G D V C D K G N G D L R V I A C L L A F K E A F P - - - E R V F L L V G N R D V N K L R F S A R L R W M L D C T M G E G A F D R R R S I T D A Q V Y A S - - - Y V G A A A K G G V L H K Y L L Q Q I A A L V D G T L F V H G A V N D A N - L A V A A L N E Q M A Q W - - - - - - - - - - - - D A S P Q W E D D Y G P - - P S A R V L A Y L A A S G - - - - - V T R V I T G H T P H - - - - - - - - G I T F V I A D T S Y S D M S A I T A I A V S S G G - - - - - - - - - : 2 3 8 : 2 3 8 : 2 3 9 : 2 3 9 : 2 3 7 : 2 2 5 : 2 2 9 : 2 2 9 : 2 3 7 : 2 3 8 : 2 3 8 : 2 3 8 : 2 3 8 : 2 3 8 : 2 3 8 : 2 3 7 : 2 3 8 : 2 3 8 : 2 3 8 : 2 3 7 : 2 3 7 : 2 3 3 : 2 4 1 : 2 0 8 : 2 3 7 : 2 3 7 : 2 3 7 : 2 3 7 : 2 3 7 : 2 3 7 : 2 3 7 : 2 2 3 : 2 3 7 : 2 3 7 : 2 3 7 : 2 2 2 : 2 3 7 : 2 3 7 : 1 8 9 : 2 2 2 : 2 3 7 : 2 3 7 : 2 3 7 : 2 3 7 : 2 3 7 : 2 3 7 : 2 3 7 : 2 3 7 : 2 3 7 : 2 3 7 : 2 3 7 : 2 3 7 : 2 3 7 : 2 3 7 : 2 3 7 : 2 3 7 : 2 3 7 : 2 3 7 : 2 3 7 : 2 0 7 : 2 3 7 : 2 3 7 : 2 3 7 : 2 3 7 : 2 3 7 : 2 2 1 : 2 4 0 : 2 3 8 : 2 4 2 : 2 3 7 : 2 3 8 : 2 3 8 : 2 1 7 : 2 3 2 : 2 3 3 : 2 3 3 : 2 3 3 : 2 3 7 : 2 3 6 : 2 0 7 : 2 3 3 : 2 3 7 : 2 3 7 : 2 3 7 : 2 3 7 : 2 3 7 : 2 3 7 : 2 3 6 : 2 3 6 : 2 3 7 : 2 3 7 : 2 3 6 : 2 3 7 : 2 3 7 : 2 3 7 : 2 3 7 : 2 3 7 : 2 3 4 : 2 3 7 : 2 3 7 : 2 3 7 : 2 3 7 : 2 3 8 : 2 3 8 : 2 3 5 : 2 1 6 : 2 3 7 : 2 3 7 : 2 3 8 : 2 3 8 : 2 3 8 : 2 3 8 : 2 3 8 : 2 3 8 : 2 3 7 : 2 3 3 : 2 3 8 : 2 2 5 : 2 3 8 : 2 3 0 : 2 3 8 : 2 2 2 : 2 3 6 : 2 3 5 : 2 3 5 : 1 3 4 : 1 3 4 : 1 3 4 : 2 3 8 : 2 3 8 : 2 3 8 : 2 3 8 : 2 2 4 : 2 2 4 : 2 3 7 : 2 3 2 : 2 3 7 : 2 3 7 : 2 4 2 : 2 2 1 : 2 2 4 : 2 2 9 : 2 3 0 : 2 3 0 : 2 3 0 : 2 3 0 : 2 3 9 : 2 3 8 : 2 3 6 : 2 2 1 : 2 2 5 : 1 5 2 : 2 2 9 : 2 2 9 : 2 3 3 : 1 9 4 : 1 9 5 : 2 4 2 : 2 4 2 : 2 4 2 : 2 3 5 : 2 2 8 : 2 2 8 : 2 2 7 : 2 2 8 : 2 2 8 : 2 2 8 : 2 2 8 : 2 2 7 : 2 2 8 : 2 3 1 : 2 4 0 : 2 3 1 : 2 3 1 : 2 2 5 : 2 2 5 : 2 2 5 : 2 3 4 : 1 9 9 : 1 9 9 : 1 9 9 : 1 9 8 : 1 9 4 : 1 9 4 : 2 0 6 : 1 9 9 : 1 9 9 : 1 9 9 : 1 9 9 : 2 0 0 : 2 0 2 : 2 0 2 : 2 0 1 : 2 0 2 : 2 0 2 : 1 9 8 : 1 9 0 : 1 8 9 : 1 8 9 : 1 8 9 : 1 9 0 : 1 8 9 : 1 7 0 : 1 8 4 : 2 0 4 : 2 0 5 : 2 2 5 : 2 2 5 : 2 2 5 : 2 2 5 : 2 2 5 : 2 2 3 GDxHG GDxVDRG GNHE HGG MVVGHT IDVG Motif 1 Motif 2 Supplemental Figure S1: Alignment of the phosphatase domain of SLP protein phosphatases from both Prokaryotes and Eukaryotes. Candidate SLP phosphatase sequences identified as detailed in Materials and Methods were aligned using MAFFT. The alignment was visualized in GeneDoc and manually edited to remove the extreme N- and C- terminal regions outside the protein phosphatase domain, plus poorly aligned regions, prior to phylogenetic tree inference. Two conserved bacterial-like phosphatase motifs (orange) were identified in addition to the known canonical PPP-family protein phosphatase motifs (blue). Of the two bacterial-like PPP-phosphatase motifs, Motif 1 represents a novel region of conservation. Motif 2 was previously reported (Andreeva and Kutuzov, 2004). The gene identifiers of each sequence used here are located in Supplemental Table S1.

Supplemental Figure S1 - Plant physiology · 2013-10-09 · Supplemental Figure S1 . Mglo SLP : Um SLP : PgraSLP : MlarpSLP : RgluSLP : BdenSL P: TgSLP : CparSL P: LbSL P: CneoS LP

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Page 1: Supplemental Figure S1 - Plant physiology · 2013-10-09 · Supplemental Figure S1 . Mglo SLP : Um SLP : PgraSLP : MlarpSLP : RgluSLP : BdenSL P: TgSLP : CparSL P: LbSL P: CneoS LP

Supplemental Figure S1 MgloSLP :UmSLP :PgraSLP :MlarpSLP :RgluSLP :BdenSLP :TgSLP :CparSLP :LbSLP :CneoSLP :SpSLP :Q1D163_MYX :F8CJ73_MYX :Q08Y53_STI :H8MYK0_COR :Q028W8_SOL :B8KKW3_9GA :A4ABU5_9GA :A0Z563_9GA :AlSLPa :AtSLP1 :CarSLPa :BrSLPb :ThalSLPb :AcSLPa :AcSLPb :CpaSLPa :CcSLPb :CsSLP :CsSLPb :GrSLPb :MdpSLPd :PperSLPb :MdpSLPe :VvSLPb :MeSLPb :PtSLPa :PtSLPb :PtSLPc :PtSLPd :RcSLPb :MgSLPa :MgSLPb :GmSLPb :GmSLPc :PvulSLPb :MtSLPb :EgSLPa :EgSLPb :CsatSLPa :CsatSLPb :LuSLPc :BdSLPa :PvSLPa :PvSLPb :PvSLPc :SiSLPa :SbSLPa :ZmSLPb :OsSLPa :PpaSLPc :PpaSLPa :SmSLPa :CrSLPa :VcSLPb :CvSLPb :CocSLPa :MpSLPc :MpSLPd :OlSLPa :OrcSLPa :OtSLPc :MpSLPb :MpSLPf :OlSLPc :OtSLPb :OrcSLPb :A9EUH1_SOR :D0LQ64_HAL :A6FXL1_9DE :A6G215_9DE :AlSLPb :AtSLP2 :CarSLPb :ThalSLPa :BrSLPa :CpaSLPc :CcSLPa :CsSLPa :MeSLPa :RcSLPa :PtSLPe :GrSLPa :CsatSLPc :GmSLPa :GmSLPd :PvulSLPa :MtSLPa :MdpSLPa :MdpSLPb :MdpSLPc :PperSLPa :LuSLPa :LuSLPb :CpaSLPb :VvSLPa :AcSLPc :MgSLPc :BdSLPb :OsSLPb :PvSLPd :SiSLPb :SbSLPb :ZmSLPa :PpaSLPb :SmSLPb :MpSLPa :MpSLPe :OlSLPb :OtSLPd :OrcSLPc :CocSLPb :CvSLPa :CrSLPb :VcSLPa :ZmSLPd :ZmSLPf :ZmSLPg :CmSLP :EhSLPa :GtSLPe :GtSLPd :FcSLP :TpSLP :EsSLPa :EsSLPb :GtSLPb :GtSLPc :GtSLPa :CpSLP :AaSLPa :TcSLPa :LmSLPa :TbSLPa :TcSLPc :CrSLPc :VcSLPc :MpSLPg :MpSLPh :OlSLPd :OrcSLPd :OtSLPa :PmSLPa :PmSLPb :ZmSLPc :ZmSLPe :EhSLPb :LmSLPc :TbSLPb :TcSLPb :LmSLPb :F4KVD8_HAL :G8T712_NIA :F9YU86_CAP :B8CJM1_SHE :A8FSQ7_SHE :A0KU52_SHE :A6WR58_SHE :A6LG58_PAR :A6L339_BAC :PbSLPa :PySLPb :PchaSLPb :PvxSLPa :PbSLPb :PySLPa :PchaSLPa :PvxSLPb :C7JGL0_ACE :G2I4P6_GLU :A9HIJ4_GLU :Q5FPF8_GLU :F0IZ02_ACI :A5FYZ4_ACI :C8W9T6_ATO :E6X796_CEL :A4APQ2_MAR :A4CIK5_ROB :G8XAS9_FLA :C7PBV5_CHI :B7KAY7_CYA :B7K033_CYA :G6H040_9CH :G6GVE8_9CH :A3IN61_9CH :I4GUD1_MIC :B8HLS9_CYA :B1XJX5_SYN :B1WW02_CYA :E0UG92_CYA :Q3M7X2_ANA :B0JIT7_MIC :F2N9L1_COR :F7UVF4_EEG :C7N2D2_SLA :C7N0S7_SLA :PcapSLP :PiSLP :PsSLP :PrSLP :PutSLP :TtSLP :

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260HRRIVALGDIHGDYEHATSILRAAGILHSWAGGSTIFVSTGDTVDRGDDTIRLYRLPQDLREQSRRVGGNVINVLGNHEMMNA---------------MMD---WRYVTPGDMASFGGPRRQAMSLHGWLGMEWMQNVTMNVQRASFVHGGITPAFAIGVDAMNKDAHSLLTKALWLS----D-GPFWYRGYALD-ACATANRAIDALG-----VSSLIMGHTPHSG-IHARCHGQIFIIDTGMSRAGRLSALEIDSYAYSAVYVPEGSRRTVAVADLHGDLDHALNVLSMASIVSTWIGGHDTLVSTGDIVDRGDDTIALYRLPVSLRQQARLAGGEVKNCLGNHEVMNA---------------IGD---WRYVTKADVESFGGVRRHAMSDQGWIGQEWLHNVTHTIPRVSFVHGGITPQYALGIDFINTVGHSLLLKGLWSE----H-GPLWYRGYATD-ACANAEKATKSLA-----VNQLVMGHTPHDG-FVTRCNNTILLIDTGISRAGQQSALIIDFDLLTALYKARPSSRIVAVGDLHGDLDHAVRVLRMAGVVDQWIGGPSILVQTGDIVDRGKATILLYKWMDALRTEAQAAGGAVVSLLGNHEYMNA---------------LGD---WRYVTKEDIETFGSARRKVMSTQGWIGKTWEASVTARIAGTVFVHGGITPEYALGISEINRIGHSLLHRALYAE----H-GPLWERSYALEDICRQIEIATQRLH-----VRRMVMGHTPQKG-ISSRCGGKILLIDTGISSAGPLTALEINYSLIQELADKKKKQRVVAIGDLHGDLPHAVRVLRLAELIDKWIGKKTVLVQTGDIVDRGRDTIVLYQLMDRLRNEAKAAGGAVVSLLGNHEYMNA---------------LGD---WRYVTEEDIETFGGKRRKLMSSEGWIGESWLKNTTARVSAIAFVHGGITPEYAIGISEINRIGQSFLNRSLYSS----H-GPLWERSYALEEICDQIEKTINLLN-----VRRLVMGHTPQKG-ILGRCQGKILLIDTGISSAGALSALEIQYTLVHGLQEGKLRQRIVAMGDIHGDLPAATKILRRAEVVDQWIGGDTILVQTGDIVDRGPDTIALYRFFQSLRPQAERAGGAVVSLLGNHEMMNC---------------LGD---YRYVTKEDIASFGGERREAFLH-GWIGQEFRASVTARVSAISFVHGGITPEYSSPITDINRIGHSILESLLWSE----R-GPMWNRDWALE-ICERVEKALEVLN-----VRRMVMGHTPQEG-ILSRCDGKILLIDTGISRAGAHSSLSLTYTLVEALYTAGRPSRIIAVGDLHGDLAQALKTLKMARIMNEWIAGSSIFVQTGDVVDRGPDTIKLYKMLYDLKVQAEEHGGQVIQLLGNHEVMNM---------------AED---LRYVTEGDYSSFGGHRRKAFDKDGWPG-NYLRNITTWVNGTVFFHGGAHPQWALGIDGMNLRAHNGLIGRSFGG----S-GPLWFRGYAED-ICKQLDKALADMN-----AVRMVVGHTPQDGSVLRRCNGKLYVIDVGISRVGNSAALEI-------------GSRILAVGDLHGDIGNTMLLLYGAGVVDNWIAGDTLLIQTGDVVDRGPDGKRIYDYFASLSAQATEQGGKIIQLLGNHDVMNI---------------CGD---FRYAHPSETIEFGGARRRQFMDGGHYG-NMLRPLSIKANGVIFSHAGIPSDFALGLSKLTQQLREELANDCAGS----Q-GPLWTRVYSMG-ICEELDKTLGILD-----SEKMVIGHTVQSGNIEVYCGGRLLLIDTGVSRYDSPRMLEIRDGS---------KGRVLVIGDIHGDLKSLITSLFLSGVINDWIAKNTLLIQLGDVVDRGSHALQIYKLFNKLKSQAPSLGSKFVGLLGNHEVMNL---------------CGQ---LHYVTDEDFQTYGGRRTFEWSKEGFVG-KYLRKLAIRVNDSLYVHAGLLPKYALGLDKLDKLSNDLLEGDFFVE----D-GPLWTRDISLG-ACKLVDETLQILG-----LSRMVVGHTIQDNRINIKCDNKLILADTGFSEAGKPCMLEILYHN---------TRHIVAVGDLHGDLPNARKVLQFSGITDDWTGDVDFFVQTGDIIDRGDDTIPLFFWMDKLRSQAAAVGGTVLSHLGNHEWMNV---------------IGD---WRYVYPTEIKTFGSVRQQMLTT-GRIGRSWAATTASRLSAISFVHGGLSPTYTLTPSRINQISDSLLAKLQYDG----N-GPLWYRGWATD-VCADVDRVLAKTG-----TRRMIMGHTPDKN-IKARCGGKIIIIDTGISHAGALSALSLYYSLVSAIYQHRRRQRLVAVGDLHGDIDNAKKTLQMARIIDKWVASTDILVQTGDIVDRGAYADDIYRLMQSLRGQAASQGGKVVSILGNHEVMNA---------------IGD---WRYVTKGDIARFGGTRQHALSAEGWLGQEWLASTTALVPTFSFTHGSLRPSYALTPAAINDLGHSLLTKALYAE----G-GPLWWRGLAER-VCEWAKNLKQKIG-----ARRIIGGHTPNEK-IVARCNASVIIIDTGISSAGVLSALEIVYTLVHAIYEHSRPTVVYAIGDIHGDFPNALDVLSAAGVVSEWTAGNATLVQTGDVVDRGPDTRKLFRWFNDLHKQAEKHGGRVVRLLGNHEFMNA---------------KGD---WRYVHPGDKASYPEPRIIDWGHSGEIGNLLLSNVTYKDNTSHFMHAGLSPEWAYREETVNELGKELLSHFMWAI----E-GPMWYRGLAQL-ACEVALNVTKTLN-----VNRLVMGHTPQHG-IVSRCEGRILLIDTGLCSAGERAVLRISQNDVEAVYRGKIVERVVAVGDVHGDVDALKEVLRLAGLIDRWIGGKTHLVQTGDVPDRGDQTRAAFDLLMRLEQEALAAGGRVHALLGNHEAMNM---------------LGD---LRYVNPGEMASFADQHRVAYSLQGRYG-QWLRAAVVRINDTLFVHGGVAPGVPGNLAELNRWVRQDFFPDHRDA----Q-GPLWFRGYALG-AEPALDAVLKRYG-----ARRMVMGHTTNDGKVKVRFNGKALLIDTGLSTGRNLAALELRGGKVNALYREGPVERVVAVGDVHGDVDALKEVLRLAGIIDRWIGGKTHLVQTGDIPDRGDQTRAAFDLLMRLEQEALAAGGRVHALLGNHEAMNM---------------LGD---LRYVSPGEMASFADQHRVAYSLQGRYG-QWLRAAVVRINDTLFVHGGVAPGVPTDLSALNRWVRQDFFPGQRNP----Q-GPLWFRGYALG-AGPALDAVLQRYG-----ARRMVMGHTTNDGKVKVRFNGKALLIDTGLSTGRNLAALELRGGKVNALYREGPVERVVAVGDVHGDVEALKEVLRLAGLIDQWTGGKTHLVQTGDIADRGARTREAFELMMRLEREALAAGGRVHLLLGNHEVMNM---------------RGD---LRYVTPEELASFAGLHRAAYGLEGRYG-RWLRPAVVRIDGTLFLHGGLHPEVPKTLGALNRWTRQDLFPDATDA----K-GPLWFRGYAQE-WSQGLDAVLERFG-----ARRMVMGHTPTDGRIGVRFGGRAVLIDTGLSTYRHLAALEIRGDRLTALYPDGRVERIVAVADVHGDVDALKEVLRLAGLIDHWIGGKAHLVQTGDLPDRGDHTRDAFELLMRLETEARKAGGRVHPLLGNHELMNM---------------RGD---LRYVTPGEFASFADQHAAAYAADGRYG-KWLRPAVIRINDTLFLHGGLAPTVPTTLEEVNRWVWQDLTPGQVDP----Q-GPVWFRGYAID-WDAGLTQVLERFS-----ARRMVMGHTPSDGRLSIRFGGRVIVIDTGLSTHRHLAALELRGDRLTALYPEGRVPRVVAVGDVHGDYNGFVEVLRSAGVIDHWAGGKTHLVQTGDVPDRGPDTRKAMDLLMQLEKEADKAGGHVHALVGNHEAMNV---------------YAD---LRYTTPAEFAAFVDNQRIAFSSEGKYG-KWIRNALVKINDTIYLHGGISPRYAMTVKQINEAVAAELNDLPMGT----D-SPLWYRGIALE-IAAHVDLVLKTND-----AQRIVISHTVTGA-IIERFGGKVVMIDTGMTAVGHRACLLLEGDKVYAIHRGEKIDRVVAIADLHGDYQSYITVLEQAGLVNRWTGGTTHLVQLGDVPDRGPDTARIIEHLMKLETQAKKAGGKVHALIGNHEVMNM---------------TGD---LRYVHPGEYEALKSRHRQHWLPNGEFG-AWVANTVVRINRSLFVHAGISPDYLRSIGDINDAVRAELAKPNVDE----R-GPLWYRGLALGDVAVEVDALLKYFD-----VDRIVVGHTPGGT-VVPRYDARVIAADSGLAQHGHLASLLIEGGKVYTLQRGQQVERVVAVADLHGDYDNYITVLRQAGVIDRWDAGKTHLVQLGDVPDRGPDSDKIIRHLMKLEEQAEKAGGKVHPLIGNHEVMNI---------------TGD---LRYVHPGEYEALTSRHRQHWHPEGQFG-AWVANTVIRINRSLFVHGGIGPDYLASMEDINDTVREELRAPDEDE----E-GPLWYRGLIMGEIAAHVDALMERFD-----VDRIVMGHTPGGT-VVPRYHGRVLAADSGIAEYGNLASVLIENGQAFTLQSGERSETVIAIGDVHGDHEQFVKLLQATKLIDRWTGGETHLVQLGDLPDRGPDTRKTMDLLLELQTSSIEQGGAVTTLIGNHDMMNV---------------MND---LRYVDPGEYKAFRSRHRLAWAPTGTYG-EWVLPTVAVVGDSLFVHGGISPDYIMSIEDINTAVHSAMGEGYYDP----L-GPLWFRGWSQDLNTMALNSILNKYG-----VARMVVAHTPVPV-VVPRYDGKIIMVDVGLSQHHGFSALKIENGQTMAMVGDRWARRIVAVGDLHGDLGKARDALQMAGVLSQWIGQDSVLVQVGDILDRGDDEIAILSLLRSLDGQAKANGGAVFQVNGNHETMNV---------------EGD---FRYVDARAFDECTDFRSILFRPGGRLACE-LAGVILRVNNWIFCHGGLLPHHVYGVERINREVSTWM-RSPRGY----D-SVVWSRLYSRETVNKILHDTLEAVG-----AKAMVVGHTPQSG-VNCEYGCSIWRVDVGMSSGSRPEVLEIRGDKARVIRSNRDARRIVAVGDLHGDLGKARDALQLAGVLSQWVGQDTVLVQVGDILDRGDDEIAILSLLRSLDDQAKANGGAVFQVNGNHETMNV---------------EGD---FRYVDARAFDECTDFRSVLLRPGGRLACE-LSGVILRVNNWLFCHGGLLPHHVYGIERINREVSTWM-RSPRGY----D-SVVWSRLYSRETVNKILHDTLEAVG-----AKAMVVGHTPQSG-VNCEYGCGIWRVDVGMSSGSRPEVLEIRGDKARVIRSNRDARRIIAVGDLHGDLSKARDALQLGGVLSQWIGQDT----VGDILDRGDDEIAILSLLRSLDVQAKANGGAVFQVNGNHETMNV---------------EGD---FRYVDARAFDECTDFRSVLFRPGGRLACE-LAGVVLRINNWVFCHGGLLPHHVYGVERINREVSTWM-RSARGY----D-SVVWSRLYSRETVSKILRDTLDAVG-----AKAMVVGHTPQSG-VNCEYGCGIWRVDVGMSSGSRPEVLEIIGDKARVIRSNRDSRRIIAVGDLHGDLSKARDALQIAGVLSQWVGEDTVVVQVGDILDRGEDEIAILSLLRLLDEQAKANGGAVFQVNGNHETMNV---------------EGD---FRYVDTRAFDECIDFRSVLFRPGGRLACE-LSGVVLRVNNWVFCHGGLLPHHVYGVERINREVSTWM-KSSRGQVESSK-TVKSSSAWIECVVGKILRDSLEAVG-----AKAMVVGHTPQSG-VNCEYGCGIWRVDVGMSSGSRPEVLEIRGDKARVIRSNQD----LAV-------------------------SSQVLVQVGDILDRGDDEIAILSLLRLLDEQAKANGGAVFQVNGNHETMNV---------------EGD---FRYVDARAFDECTDFRSVLFRPGGRLACE-LAGVILRVNDWVFCHGGLLPHHVYGVERINREVATWM-RSYRGY----D-SVVWSRLYSRETVSKILRDTLEAVG-----AKAMVVGHTPQSG-VNCEYGCSIWRVDVGMSSGSRPEVLEIRGDKARVIRSNQDGRRIVAVGDLHGDLAQTRCALELAGVLSLWTGEETVLIQLGDILDRGEDEIAILSLLRSLSNQAKSKGGAVFQLNGNHETMNV---------------EGD---FRYVDPGAFNECGDFRSALLRPGGPLACE-LAAVVLKVDDWVFCHGGLLPRHVYGIERMNREVSHWM-KGLRGY----D-SVVWNRLYSRDLIQAVLEDTLDAMG-----AKAMVVGHTPQAG-INSKYSSSIWRIDVGMSSGSRPEVLEIIDNEARVIRSNRQGRRIVAVGDLHGDLAQTRCALELAGVLSLWTGEETVLIQLGDILDRGEDEIAILSLLRSLSNQAKSKGGAVFQLNGNHETMNV---------------EGD---FRYVDPGAFNECGDFRSALLRPGGPLACE-LAAVVLKVDDWVFCHGGLLPRHVYGIERMNREVSHWM-KGLRGY----D-SVVWNRLYSRDLIQAVLEDTLDAMG-----AKAMVVGHTPQAG-INSKYSSSIWRIDVGMSSGSRPEVLEIIDNEARVIRSNRQGRRIIAVGDLHGDLDQARFALQMAGVLSLWTGGETVLVQLGDILDRGEDEIAILSLLRLLDVQAKDVGGAVFQVNGNHETMNV---------------EGD---FRYVEAGAFDECGAFRTALFRPGGPLACE-LASVVLRVNDWVFCHGGLLPNHVYGIERMNKEVSSWM-RGFRGY----D-SVVWNRLYSRDNINAILQDTLQAVG-----AKAMVVGHTPQEG-VNCKYNCSIWRVDVGMSSGSRPEVLEISDDKARVIRSKREGRRIVAVGDLHGDLDQARCALAMAGVLSLWTGGESVLIQLGDVLDRGEDELAILSLLRSLDMQAKAEGGAVFQVNGNHETMNV---------------EGD---FRYVDSGGFDECSDFRSVLFRPGGPMACE-LAGVVLKVNDWVFCHGGLLPHHVYGLERMNNEVSLWM-KGLRGY----D-SVVWNRLYSRDIINAVLQDTLRAVG-----AKAMVVGHTPQAG-ANCEYNCSIWRIDVGMSSGSRPEVLEITDNKARVISSKRDGRRIVAVGDLHGDLDQARCALEMAGVLSLWTGGESVLIQLGDVLDRGEDELAILSLLRSLDMQAKAEGGAVFQVNGNHETMNV---------------EGD---FRYVDSGGFDECSDFRSVLFRPGGPMACE-LAGVVLKVNDWVFCHGGLLPHHVYGLERMNNEVSLWM-KGLRGY----D-SVVWNRLYSRDIINAVLQDTLRAVG-----AKAMVVGHTPQAG-ANCEYNCSIWRIDVGMSSGSRPEVLEITDNKARVISGKRDGRRIVAVGDLHGDLDQARCALEMAGVLSLWTGGESVLIQLGDVLDRGEDELAILSLLRSLDMQAKAEGGAVFQVNGNHETMNV---------------EGD---FRYVDSGGFDECSDFRSVLFRPGGPMACE-LAGVVLKVNDWVFCHGGLLPHHVYGLERMNNEVSLWM-KGLRGY----D-SVVWNRLYSRDIINAVLQDTLRAVG-----AKAMVVGHTPQAG-ANCEYNCSIWRIDVGMSSGSRPEVLEITDNKARVISGKRDGRRIVAVGDLHGDLDQARYALEMAGVLSLWTGEDAVLVQLGDVLDRGDDEIAILSLLRSLDIQAKAKGGAVFQVNGNHETMNV---------------EGD---FRYVESGAFDECADFRSVLFRPGGPLACE-LAAVALKVNDWIFCHGGLLPHHVYGIEKMNKEVSQWM-RGLKGY----D-SVVWNRLYSRNIINAILQETLQALG-----AKAMVVGHTPQSG-ANCEYNCSIWRIDVGMSSGSRPEVLEIRDDKARVIRSKRN----MSVGDLHGDLGQTRCALETAGVLSVWIGGETVLIQLGDILDRGEDEIAILSLLRSLDMQAKAEGGAVFQVNGNHETINV---------------EGD---FRYVDTGGFDECLDFRSILLRPGGPLARE-LAAVVLKVNDWVFCHGGLVPQHVYGVERMNREVSDWM-RGLRGY----D-SVVWNRLYSRDTINYILQQTLQAVG-----AKGMVVGHTPQTG-ANCEYDCSIWRIDVGMSSGSRPEGLSSLNM----------GRRIVAVGDLHGDLDQTRCALEMAGVLSLWTGGETVLIQLGDILDRGEDEIAILSLLRSLDIQAKDEGGAVFQVNGNHETMNV---------------EGD---FRYVETGGFDECIDFRSILLRPGGPLACE-LAAVVLKVNDWVFCHGGLIPNHVYGVERMNREVSHWM-RGLRGY----D-SVVWNRLYSRDTIHSILEETLHAVG-----AKAMVVGHTPQTG-ANCKYNCSIWRIDVGMSSGSRPEVLEIKDNKARVIRSKKDYRSVLCVGDLHGDLGQTRCALETAGVLSVWIGGETVLIQLGDILDRGEDEIAILSLLRSLDMQAKAEGGAVFQVNGNHETINV---------------EGD---FRYVDTGGFDECLDFRSILLRPGGPLARE-LAAVVLKVNDWVFCHGGLVPQHVYGVERMNREVSDWM-RGLRGY----D-SVVWNRLYSRDTANKLHSSTDATSG-----NGGGAYSSTYGKL-VRCEYDCSIWRIDVGMSSGSRPEVLEIKDNKARVIRSKKDGRRIVAVGDLHGDLAQARCALEMAGVLSLWTGGDTVLVQLGDILDRGEDEIAILSLLRSLDIQAKASGGAVFQVNGNHETMNV---------------EGD---FRYVDSGAFDECTDFRSILLRPGGLLACE-LAAVVLKIDDWVFCHGGLLPHHVYGIERMNREVSHWM-RGLRGY----D-SVVWNRLYSRDVIYSLLEETLQAVG-----AKAMVVGHTPQVG-VNCKYDCSIWRIDVGMSSGSRPEVLEIRDNTARVIRSKRDGRRIVAVGDLHGDLDQARCALEMAGVLSLWIGGETVLIQLGDILDRGEDEIAILSLLRSLDIQAKAQGGAVFQINGNHETMNV---------------EGD---FRYVDSGAFDECTDFRSILLTPGGPLACE-LASVILKVNDWIFCHGGLLPQHVYGIERMNSKVSQWM-KGLKGY----D-SVVWNRLYSRDVILSILEETLQAIG-----AKAMVVGHTPQAG-VNCKYNCSVWCVDVGMSSGSRPEVI---------------GRRIVAVGDVHGDLDQARCALEIAGVLSLWTGGETVLIQLGDVLDRGEEEIAILSLLRSLDIQAKAQGGAVFQVNGNHETMNV---------------EGD---FRYVDSGAFDECSDFRSILLRPGGPLACE-LAAVVLKINDWVFCHGGLLPQHVYGVERMNYEVSHWM-RGLKGF----D-SVVWNRLYSRDMIQSVLEETLQLLG-----AKAMVVGHTPQTG-VNCKYNCSIWCIDVGMSSGSRPEVLEIVENKARVIRSKRDGRRIVAVGDVHGDLDQARCALEIAGVLSLWTGGETVLIQLGDVLDRGEEEIAILSLLRSLDIQAKAQGGAVFQVNGNHETMNV---------------EGD---FRYVDSGAFDECSDFRSILLRPGGPLACE-LAAVVLKINDWVFCHGGLLPQHVYGVERMNYEVSHWM-RGLKGF----D-SVVWNRLYSRDMIQSVLEETLQLLG-----AKAMVVGHTPQTG-VNCKYNCSIWCIDVGMSSGSRPEVLEIVENKARVIRSKRDGRRIVAVGDVHGDLDQARCALEIAGVLSLWTGGETVLIQLGDVLDRGEEEIAILSLLRSLDIQAKAQGGAVFQVNGNHETMNV---------------EGD---FRYVDSGAFDECSDFRSILLRPGGPLACE-LAAVVLKINDWVFCHGGLLPQHVYGVERMNYEVSHWM-RGLKGF----D-SVVWNRLYSRDMIQSVLEETLQLLG-----AKAMV-------------------------------------------------GRRIVAVGDVHGDLDQARCALEIAGVLSLWTGGETVLIQLGDVLDRGEEEIAILSLLRSLDIQAKAQGGAVFQVNGNHETMNV---------------EGD---FRYVDSGAFDECSDFRSILLRPGGPLACE-LAAVVLKINDWVFCHGGLLPQHVYGVERMNYEVSHWM-RGLKGF----D-SVVWNRLYSRDMIQSVLEETLQLLG-----AKAMVVGHTPQTG-VNCKYNCSIWCIDVGMSSGSRPEVI---------------GRRIVAVGDLHGDLDQARCALEMAGVLSLWIGGETVLVQLGDILDRGEDEIAILSLLRSLDIQAKAEGGAVFQVNGNHETMNV---------------EGD---FRYVDSGAFDECTDFRSVLLRPGGPLACE-LASVILRINDWIFCHGGLLPHHVYGIERINREVSQWM-KGLRGY----D-SVVWNRLYSRDMILSILEETLQSAG-----AKAMVVGHTPQAG-VNCKYNCSVWRIDVGMSSGSRPEVLEIQNDKAKVIRSRKDGRRIIAVGDLHGDLDKARYALQMAGILSLWIGGQTVLVQLGDILDRGEDEIAILSLLKSLNIQAKLNGGAVFQVNGNHETMNV---------------EGD---FRYVDSGGFDECADFRSVLLRPGGPLASE-LAAVVLKVNDWIFCHGGLLPHHVYGIERINREVSYWM-EGLRGY----D-SVVWSRLYSRDTIESILRETLQAVG-----AKAMVVGHTPQTG-VNCDFNCSIWRIDVGMSSGSRPEVLEIREGRARAIRSKRDGRRIIAVGDLHGDLDKARYALQMAGILSLWIGGQTVLVQLGDILDRGEDEIAILSLLKSLNIQAKLNGGAVFQVNGNHETMNV---------------EGD---FRYVDSGGFDECADFRSVLLRPGGPLASE-LAAVVLKVNDWIFCHGGLLPHHVYGIERINREVSYWM-EGLRGY----D-SVVWSRLYSRDTIESILRETLQAVG-----AKAMVVGHTPQTG-VNCDFNCSIWRIDVGMSSGSRPEVLEIREGRARAIRSKRDGRRILAVGDLHGDLKQARSALEMAGVLSLWTGGETVLVQLGDILDRGEDEIAILSLLRSLDKQAKAKGGAVFQVNGNHETMNV---------------EGD---FRYVDSGGFDECNDFRSILFRPGGLLARE-LAAVVLKVNDWVFCHGGLLPHHVYGLERMNKEVSEWM-RGQRGY----D-SVVWNRLYSRDTVCSILDETLQAVG-----AKAMVVGHTPQIG-VNCKYNCSIWRVDVGMSSGSRPEVLEIIDDKARVIRCKRDGRRILAVGDLHGDLKQARSALEMAGVLSLWTGGETVLVQLGDILDRGEDEIAILSMLRSLDRQAKEKGGAVFQVNGNHETMNV---------------EGD---YRYVESGGFDECNDFRSILFRPGGLLARE-LAAVVLKVNDWVFCHGGLLPHHVYGLERMNKEVSEWM-RGQRGY----D-SVVWNRLYSRDTVCSILDETMQAVG-----AKAMVVGHTPQIG-VNCKYNCSIWRVDVGMSSGSKPEVLEIIDDKARVIRCKRDGRRILAVGDLHGDLKQARSALEMAGVLSLWTGGETVLVQLGDILDRGEDEIAILSLLRSLDKQAKAKGGAVFQVNGNHETMNV---------------EGD---FRYVDSGGFDESNDFRSVLFRPGGLLARE-LAAVVLKVNDWVFCHGGLLPHHVYGLERMNKEVSEWM-KGQRGY----D-SVVWNRLYSRDAVCSILDETLQAVG-----AKSMVVGHTPQTG-VNCKYNCNIWRIDVGMSSGSRPEVLEIIDNQAKVIRCKRDGRTILAVGDLHGDLKQARYALEMAGVLSLWTGGENVLIQLGDILDRGEDEIAILSLLRSLDKQAKSKGGAVFQVNGNHETMNV---------------EGD---FRYVDSGGFDECSDFRSILFRPGGPLACE-LAGVALKVNDWVFCHGGLLPHHVYGLERMNKEVSEWM-RDPRGY----D-SVVWNRLYSRDSVCSVLEETLQAVD-----AKAMVVGHTPQIG-VNCKYNCSIWRVDVGMSSGSRPEVLEIIDDKARVIRSKTDGRRIVAVGDLHGDLEQARRAFQMAGVLSTWTGKETVLVQLGDILDRGENEIAILSLLRSMDKQAQEDGGAIFQINGNHETMNV---------------EGD---FRYVESGAFEECAGFRSVLLRPGGPLACE-LAAVVLKVNDWIFCHGGLLPHHVYGIERMNFEVSNWM-RGLRGY----D-SVVWSRLYSRDVIQSILEETLQAVN-----AKAMVVGHTPQAG-VNCKYNCSIWRIDVGMSSGSRPEVLEIVDGKARAIKGRRDGRRIVAVGDLHGDLEQARRAFQMAGVLSTWTGKETVLVQLGDILDRGENEIAILSLLRSMDKQAQEDGGAIFQINGNHETMNV---------------EGD---FRYVESGAFEECAGFRSVLLRPGGPLACE-LAAVVLKVNDWIFCHGGLLPHHVYGIERMNFEVSNWM-RGLRGY----D-SVVWSRLYSRDVIQSILEETLQAVN-----AKAMVVGHTPQAG-VNCKYNCSIWRIDVGMSSGSRPEVLEIVDGKARAIKGRRDARRIVAVGDLHGDLKQTRLALEMAGVLGLWTGGQTVLVQLGDILDRGEDEIAILSLLRSLDVQARAQGGAVFQVNGNHETMNV---------------EGD---FRYVDSGAFDECLNFRSILFRPGGRLARE-LAAVVLKVNDWVFCHGGLLPHHVYGIERMNREVSQWM-KGLRGY----D-SVVWNRLYSRDFINSILKDTLEAVG-----AKAMVVGHTPQAG-VNCKYNCSIWRVDVGMSSGSRPEVLEIRDDKVRVIRSKRDARRIVAVGDLHGDLKQTRLALEMAGVLGLWTGGQTVLVQLGDILDRGEDEIAILSLLRSLDVQARAQGGAVFQVNGNHETMNV---------------EGD---FRYVDSGAFDECLNFRSILFRPGGRLARE-LAAVVLKVNDWVFCHGGLLPHHVYGIERMNREVSQWM-KGLRGY----D-SVVWNRLYSRDFINSILKDTLEAVG-----AKAMVVGHTPQAG-VNCKYNCSIWRVDVGMSSGSRPEVLEIRDDKVRVIRSKRDGRRIVAVGDLHGDLDQTRSALRIAGVLSRWTGGQTVLVQLGDVLDRGGGEIAILSLLRSLDVQARLQGGAVFQINGNHETMNV---------------EGD---FRYVDSTGFDECLDFRSTLLRPGGALACE-LAGVLLKINDWVFCHGGILPHHVHGVERMNREVSQWM-KGLRGY----D-SVVWNRLYSQDLIEAALYDTLGSLD-----AKGMVVGHTPQRG-ANCECNGRIWRVDVGMSKGSRPEVLEINESKTRVLRLGRDGRRIVAVGDLHGDLYQTRAALVMAGVLSLWTGGQTVLVQVGDILDRGEDEIAILSLLSSLNMQAKSQGGAVFQVNGNHETMNV---------------EGD---FRYVDPGSFDECMRYRASLLKQGGPLACE-LAPVVLVVNDWIFCHGGLLPHHVYGLERINKDVSNWM-QGSRGY----D-SVVWTRFYSQDSSSLVAEQTLKSVG-----AKGMVVGHTPQRG-VNCKCDGKVWCVDVGMSYGSRPEVLEIINDRARVIKDRRGGRRIVAIGDAHGDLSQTRAALVLAGVLSVWTGGRTVLVQVGDILDRGEDEIAILSLLSSLSVQAKSQGGAVFQVNGNHETMNV---------------EGD---FRYVYPGGFDECIRFRSSLFKRGGPLACE-LAPVVLKINDWIFCHGGLLPHHVYGIERMNIEVSTWM-KSSRGY----D-SVVWSRMYSQDSSSIIAEETLKSVG-----AKGMVVGHTPQRG-VNCKCDGKVWCIDVGMSYGSRPEVLEIVNDRPRVLKKRRDGRRIVAIGDAHGDLSQTRAALVLAGVLSVWTGGRTVLVQVGDILDRGEDEIAILSLLSSLSVQAKSQGGAVFQVNGNHETMNV---------------EGD---FRYVYPGGFDECIRFRSSLFKRGGPLACE-LAPVVLKINDWIFCHGGLLPHHVYGIERMNIEVSTWM-KSSRGY----D-SVVWSRMYSQDSSSIIAEETLKSVG-----AKGMVVGHTPQRG-VNCKCDGKVWCIDVGMSYGSRPEVLEIVNDRPRVLKKRRDGRRIVAIGDVHGDLSQTRAALVLAGVLSVWTGGRTVLVQVGDILDRGADEIAILSLLSSLNVQAKPQGGAVFQVNGNHETMNV---------------EGD---FRYVDPGGFDECMRFRSSLFKRGGPLACE-LAPVVLKINDWIFCHGGLLPHHVYGIGRMNREVSRWM-KSSRGY----D-SVVWSRLYSQDSSSIVAEETLESVR-----AKGMVVGHTPQHG-VNCKCDGKVWCIDVGMSYGSRPEVLEIVNDSPRVLKKRRDDRRIVAIGDVHGDLSQTRAALVLAGVLSVWTGGRTVLVQVGDILDRGKDEIAILSLLSSLNLQAKSQGGAVFQVNGNHETMNV---------------EGD---FRYVDPGGFDECIRFRSSLFKRGGPLACE-LAPVVLKINDWVFCHGGLLPHHVYGIERMNREVSMWM-KCSRGY----D-SVVWSRLYSHDPSSIVAEQTLKSVG-----AKGMVVGHTPQGG-VNCKCDGKVWCVDVGMSYGSRPEVLEIVNDRPRVLKKRRDGRRIVAIGDVHGDLSQTRAALVLAGVLSLWTGGRTVLVQVGDILDRGEDEIAILSLLSSLNMQAKSQGGAVFQINGNHETMNV---------------EGD---FRYCDPGGFDECVRFRSSLLKRGGPLACE-LAPVVLKINDWIFCHGGLLPHHVYGIERMNREVSIWM-KCSRGY----D-SVVWSRLYSQDPSSIVAEQTLEAVG-----AKGMVVGHTPQHG-VNCKCDGKVWCVDVGMSSGSRPEVLEIVNDRPKVLKKRREGRRIVAIGDAHGDLSQTRAALVLAGVLSVWTGGRTILVQVGDILDRGEDEIAILSLLSSLNMQAKSQGGAVFQVNGNHETMNV---------------EGD---FRYCDPGGFDECMRFRSSLLKRGGPLAHE-LAPVVLKINDWIFCHGGLLPHHVYGIERMNREVSMWM-KCSRGY----D-SVVWSRMYSQDPSSIAAEQTLEAVG-----AKGMVVGHTPQHG-VTCKCDGKVWCVDVGMSCGSRPEVLEIVNDRPRVLKERREGRRIVAVGDLHGDLNQTRAALVMAGLLSVWTGGQTVLVQVGDILDRGEDEIAILSLLSSLNMQAKSQGGAVFQVNGNHETINV---------------EGD---YRYVDPGAFDECIRFRSSLFKRGGPLACE-LAPVVLSVNDWIFCHGGLLPHHVYGIERMNREVSVWM-KSSRGY----D-SVVWSRLYSQGPSSVVAERTLKSVG-----AKGMVVGHTPQRG-VN-------WYLL--FSLG---------------------DRRIIAIGDLHGDFERAQWALQLAGVMSRWTGGTTVLVQIGDVLDRGEDEITILSLLAWLGKQARSKGGAVFQILGNHETMNV---------------AGD---FRYVAPGGFQEAEAFRTKLLSPGGPLARQ-LAGVVLKVNDWLFAHGGVLPHHVYGLERMNREVSLWM-KNIKGF----D-SIVWSRLYSKENACGILTAALSATN-----SRGLIVGHTPQIG-ANSKCDGRIWRIDVGMSSGALPEVLEIVDDKVRILSVAEENRRIVSIGDLHGDFERAQEALELAGVLSRWTGGTTILVQIGDVLDRGEDEIAILSLLALLGREARSKGGAVFQLLGNHEAMNV---------------AGD---FRYVAPGGFLEAEVFRTKLLSPGGPLATH-LAGVVLKVNDWLFAHGGVLPYHVYGLERMNREVSLWI-QKEKGY----D-SVVWSRLYSKENACGTLAAALSATN-----SRGLVVGHTPQIG-GNSKCDGRVWRIDVGMSSGALPEVLEIVDDKVRILCAREEERRIVAVGDLHGDLRQTKRALRVAGVLSNWTGGTTVLVQVGDILDRGPDEIAILSLLWHLTEQARSKGGAVFQVHGNHETMNV---------------SHE---FNDTPDCGFEDSQHFRVLLFSPGGPLALE-LSGVVLKINDWLFAHGGLLPHHVYGLEKMNSEVSNWM-KGGKGF----D-SIVWSRLYSRKTACAVLQQTLDAVK-----AKGLVIGHTPQNG-ANSECDGKVWRIDVGMSRGATPQVIEIVGDEVKVLSCQKETGRIIAIGDLHGDLDKAVEALKLGRVISSWVGGDTVVVQLGDVLDRGDVEIGIINLLRYLDTEARKQGGAVYMLNGNHESLNV---------------CGD---FRYVTPGAFAESALYRYSLYKPGGDLARE-FSPTVLVVNDTVFAHGGLLPTHVYGIERLNSEVAAWM-RGDGDA----N-SVMWNRTLSKERACNALKQALAKVR-----GKRLVVGHTPQGG-VNCECENQVWRIDVGMSYGRPVQVIEIVPPEVRVIRNTPNTGRIVAIGDLHGDLDKAVEALKLGRVIRAWVGSDTVVVQLGDVLDRGDVEIGIINLLRYLDSEARKCGGAVYMLNGNHESLNV---------------CGD---FRYVTPGAFAESAMYRYSLFKPGGDLAKE-FAPTVLVVNDTVFAHGGLLPIHVYGIERLNSEVAAWM-RGDGDA----N-SVMWNRTLSKERACRALQQALAKVH-----GKRLVVGHTPQSG-VNCECENQVWRIDVGMSYGRPVQVLEITQHEVRIIRSTPTTGRIIAIGDIHGDLQKALSCLEMAGVLAKWVGGDTVVVQLGDVLDRGDCEIGSVLLLRELDRQARQQGGAVYMLNGNHESLNV---------------AGD---FRYVTPGAFFESARARWYLYQPGGAMARE-LAATVLVVNDVVFAHGGLLPHHLYGLQRINDEVAEWM-NGAGDS----S-SVQWNRTFGKERMNFQLRATLESLN-----ARAMVVGHTPQSG-VNCECDGRVWRVDAGMSSGAAPQV----------------SGRIIAIGDIHGDVQKAITSLKLGGVLVVWCGGNTVVVQLGDVLDRGDSEIGAIILLRELDRQARLQGGAVYMLNGNHESLNL---------------LGAAMWRRYVTPGGFRESGLVRLHLYSPGGRLACE-LAPTVLIINDTVFAHGGVLPNHVYGLERLNAEVAAWM-RGAGGP----D-SVMWNRQFGHERACMDLDATLRLLG-----ARQLIVGHTPQNG-ANCECNGRVWRMDVGMSKGAAPQVLEIEPEDIRLLCPPSVKGRVVALGDVHGDIGQARRALTIAGVLGTWIGGDTVVVQVGDVLDRGDDEIAILILLQKLHKAAQADGGAVYILNGNHEVLNV---------------SGD---FRYVTQGAFQESTRFRVGLFSPGGPLAQQ-LASTVLIVNDTVFAHGGLMPRHVFGLEKLNNAVADWM-RGAGSK----D-SVVWNRTFGQENACETLGKTLDAID----GAKRLVVGHTPQGG-CNAECDGRIWRIDVGMSFGADPEVIEIVGDEVRVLTSRVPPGRVVALGDVHGDIGQARRALTIAGVLGEWTGGNTVVVQVGDVLDRGDDEIAILILLQKLHKQAEAQGGAVYILNGNHEVLNV---------------SGD---FRYVTQGAFQESARFRVGLFSPGGPLAQQ-LASTVLIVNDTVFAHGGLMPRHVFGLERLNNAVADWM-RGAGSK----D-SVVWNRTFGTENACEVLGNTLDAISEKYGAAKRLVVGHTPQGG-CNGECDGRIWRIDVGMSFGADPEVIEIDGDEVRVLNSRVP-GRVVAIGDLHGDIGQARRALRMAGVLDRWVGGDTTLVQLGDILDRGDDEIGILILLQKLDKEAQKQGGRVYVMNGNHEVLNV---------------SGD---FRYVSRGAFGESTRFRIGLFSPGGPLAQQ-LSHTVLIVNDTVFAHGGLVPRHVFGLDKLNRAVTDWM-RGKGGR----D-SIVWHRAYGTEKSCELLGKTLGMID----GVSRLVVGHTPQGG-ANCECNGQIWRIDVGMSFGAEPQVLEIDGDEVRVLSSSSVPGRVIAIGDLHGDIGQARRALRLAGVLGTWVGGDTTVVQVGDILDRGDDEIGILILLQKLEKEARKQGGGVYVLNGNHEVLNV---------------SGD---FRYVSRGAFGETMRFRIGLFSPGGPLAQQ-MSHTVLIVNDTVFAHGGLVPRHVFGLDKLNRAVTDWM-RGKGGR----D-SIVWHRGYGTERSCALLGETLGMID----GANRLVVGHTPQGG-ANCECDGRIWRIDVGMSFGADPQVLEIDGQEVRVLTPTNMFGRTVEVSDLAGAMGQARRLPHMRRYRAAWVGGNATLVQLGDILDRGDDEIGILILLQKLDKEAKKAGGAVYVMNGNHEVLNI---------------SGD---FRYVTRGAFGETTRFRIGLFSPGGPLAQQ-LSHTVLIVNDTVFVHGGLVPRHVYGLDKLNRAVSDWM-RGKGGR----D-SIVWHRGYGTENSCELLEKTLGMID----GANRMVVGHTPQGG-ANCECDGKIWRIDXXXXXXAEPQVLEIDGGDVRVITSASS-----------------MKALECAKVMDKWCGGDTVVVQVGDILDRGDNELAIMRKFRALAKDARAAGGDFIVINGNHEIMNV---------------LGD---FRYVTKGAYGECARYRRALFLPGGEMAVK-MAPTVLQVDDTVFAHAGIDESHVYGFARINAEVSQWM-AGSLEE----K-GVVWTREYGGADACRRLEKALDATG-----AKRIVIGHTPQKG-VNSGCGGKVWRADVGASRGNTPQVIEIVNGRVRVLSA---GRRLVAVGDIHGDFAQAMKALELSKCMNKWIGGTTVLVQVGDILDRGDNELAIMRKFQKLAKEAKEAGGDVVVMNGNHEIMNV---------------MGD---FRYVTKGAFGECRRWRRDLFLPGGEMAVK-MAPTVLQVGDTVFAHAGITENHVYGFQRLNNEVAAWM-VGKLEE----K-GVVWTRDYGGAEACKRLTEALDATG-----AKRLIVGHTPQKG-INSGCGGKVWRSDTGMSRGNTPQVIEIVNGRVRIL-----GRRLIAIGDLHGDFLAMVKSLELAQVIDKWNGGDAVVVQVGDVLDRGDSEIAILRKLRSLAKQAKEAGGDLITMNGNHEIMNV---------------MGD---FRYATPGAFEECRRYRQQLFKPGGEIAKW-LAPTVLVVDDTVFAHAGIDLSHVYGFERINKEVAMWM-EGKLES----D-GVVWTRDYGGKDSCRRLASALEGAD-----AKRLVIGHTPQTG-VTSGCKGTVWRVDVGASRGNSAQVIEIIGGKVRVLA----GRRLVAVGDLHGDFLAAVRALELAGVMDKWVGGDAVVVQVGDVLDRGDSEIAIMRKLRALRKQARQVGGDVVCMNGNHEIMNV---------------MGD---FRYATPGAFEECRRYRQQLFKPGGELAMW-LAPTVLVVDDTVFAHAGIDLSHVYGFERINKEVSMWM-QGKLES----D-GVVWTRDYGGKDACRKLNTALDAAG-----AKRLVIGHTPQTG-VTNGCKGALWRVDVGASRGHDVQVIEIVNGRTRVLA----GRRLIAIGDLHGDFLAMVRSLELAGVCDKWIGGNAVVVQVGDVLDRGDSEIAILRKLRALKRQAKEQGGDVITMNGNHEIMNV---------------MGD---FRYATPGAFEECRLYRQKLFSPGGEIAKW-LAPTVLVVDDTVFAHAGIDLSHVYGFERINREVSLWM-QGKLES----D-GVVWTRDYGGKDACRRLGAALDAAE-----AKRLVIGHTPQTG-VTSGCKGAVWRVDVGASRGNAAQVIEVIGGRVRVLA----ADRVVAIGDVHGDLAATRAALRIAGAIDRWIGGKLVLVQTGDELDRGDDEQTIVDLFDRLAVEARAAGGAVYALNGNHEVMNV---------------QLD---FRYVTEGGFKDFEDVRAAAFAPGGLYARK-LADVIIAVGDTVFTHGGVLPAHTYGISRINREVRAWM-EGKAAE----D-SPVWARLYSSDPPCAALDQTLAAMS-----AKRMVVGHTVQHG-ATSACGDKIWRIDVGMASHGKPAALEIVGDTVRVLTPEATPARVVAIGDLHGDLDAALRALSLAGAIALWTGGDMVLVQTGDVLDRGDDEQAILDLLARLEREARAAGGAVHALLGNHETMNA---------------AGD---FRYVTPGGFSDFADARAAAFLPGGVYAER-LANTVVVVGDTVFAHGGVVPRWAYGIERVNAELRCWL-AGELAE----D-NPMWSRDFSREPACDALERALAALD-----ATRMVVGHTPQDG-ITSACDGRVWRIDTGMAAHGAVQALELRGDSARILSEDE---------------------------MDKWIGGSLVIVQTGDQLDRGDGEQAILELLARLQHEAKAAGGAIHILNGNHEFMNA---------------MGD---LRYVTPGGLVDFADARVAAFLPGRPWAKE-LGNTVVVVGDTAFVHGGVLPAYAGDITTLNREARAFL-NGEVDP----D-GPVWSRHYSDE-DCALLDQALAKLE-----VKRMVVGHTVHEG-IQSACDEKVWMVDVGMAAHGPTQVLVIAGAEVSVLAG---VPHIIAFGDVHGDFVAMAEVLLGAGIVDHWIAGETWVVQVGDQLDRGYQEEEIMNLFEQLRVEAAEAGGRFLALNGNHEIMQA---------------EGR---MDYVFD--LEAFGGLRVEAFAPGGEWALV-LANVIVKVGRTVFVHGGALPEHALGIENMNDAAKAWL-VGDDGS----G-SIVWDRTYSDDDRCELLTAALAAMD-----ADRIVVAHTIQPG-INAICDDRAWRIDTGMADYGPIEALEITGDVASVIQME--PERLVAVGDLHGDLDKSREAFKIAGLIDRWTGGSTMVVQVGDVLDRGGEELKILYFLEKLKREAERAGGKVLTMNGNHEIMNI---------------EGD---FRYVTKTGLEEFQVWRIAALRPEGPISKRFLTQTVAVVGDSVFVHGGLLAEHIYGLERINEEVRGWI-NGLRGG----N-SVVWLRKFSEEMDCAALEHALSTIG-----VKRMIMGHTIQAG-INGVCNDKAIRIDVGMSKGGLPEVLEIRR-DVRILTSNPLPERLVAIGDLHGDLEKSREAFKIAGLIDRWTGGSTMVVQVGDVLDRGGEELKILYFLEKLKREAERAGGKILTMNGNHEIMNI---------------EGD---FRYVTKKGLEEFQIWRIAALRPDGPIAKRFLTQTVAVVGDSVFVHGGLLAEHIYGLERINEEVRGWI-NGFRGG----N-SVVWLRKFSEEMDCAALEHALSTIG-----VKRMIMGHTIQAG-INGVCNDKAIRIDVGMSKGGLPEVLEIRR-DVRIVTSNPLPERLVAIGDLHGDLEKSKESFRIAGLIDRWTGGSTVVVQVGDVLDRGGEEIKILYFLEKLKREAERSGGKVLTMNGNHEIMNV---------------EGD---FRYVTKKGLEEFQIWRIAALRPEGPIAKRFLTQTVAVVGDSVFVHGGLLAEHIYGLERINEEVKGWI-NGLRGG----N-SVVWLRKFSEEMDCAALEHALSTIG-----VKRMIMGHTIQAG-INGVCNDKAIRIDVGMSKGGLPEVLEIRR-DVRIVTSNPLPERLVAIGDLHGDLDKSKEAFRIAGLIDKWTGGSTMVVQVGDVLDRGGEELKILYFLEKLKREAEKSGGKILTMNGNHEIMNV---------------EGD---FRYVTEKGLEEFQIWRIAALRPEGPIAKRFLSQTVAVVGDSLFVHGGLLAEHIYGLERINEEVTCWI-NGLRGG----N-SVVWLRKFSDEMDCSALEHALSTIG-----VKRMIMGHTIQAG-INGVCDNKAIRIDVGMSKGGLPEVLEIRK-DVRIVTSNPLPDRLVAIGDLHGDLEKSKEAFRIAGLIDRWTGGSTMVVQVGDVLDRGGDELKILYFLERLKREAEREGGRVVTMNGNHEIMNI---------------EGD---FRFVTKEGLEEFRVWRIAALRPQGPIAKRFLSQTVAVVGDSVFVHGGLLAEHVYGLERMNEEVTSWI-NGLRGG----N-SVVWLRKFSDERDCAALEHALSTIG-----VRRMIMGHTIQAG-INGVCGDKAIRIDVGMSKGGLPEVLEIRK-DVRIVTSNPLPERLIAIGDLHGDFDKSKQAFRIAGLIDKWIGGSTTVVQIGDVLDRGGNELKILYFIEKLKREAAKTGGKIITMNGNHEIMNM---------------EGD---FRFVTKEGLDEFRVWRIAALRPEGPISRRFFTVTVLVVGDSIFVHGGLLPEHVYGLERINQEVRNWI-NGSRGR----D-GVVWVRRFSREQDCSALEHVLATVG-----VKRMIMGHTIQSG-INGACNNRAIRIDVGMSSGGLPEVLEIDR-NLQVLTSNTIVDRLIAIGDLHGDLEKSKQALRLAGLINQWTGGTATVVQIGDVLDRGDDEIKILYLLEKLKREAEKSGGKFITMNGNHEIMNI---------------EAD---FRYATEMGLKEFEDWRIAALRPDGPIARRFLSTTVLVVGDSVFVHGGLLKQHVYGLERINREVRDWI-NGLKGR----H-AVVWLRKFSDE-DCSALEHALATLG-----VKRMIMGHTIQKG-INAVCDNRAIRIDVGLSRGGLPEVLEING-NLLVLTANPLVDRLIAIGDLHGDLEKSKQALRLAGLINQWTGGTATVVQIGDVLDRGDDEIKILYLLEKLKREAEKSGGKFITMNGNHEIMNI---------------EAD---FRYATEMGLKEFEDWRIAALRPDGPIARRFLSTTVLVVGDSVFVHGGLLKQHVYGLERINREVRDWI-NGLKGR----H-AVVWLRKFSDE-DCSALEHALATIG-----VKRMIMGHTIQKG-INAVCDNRAIRIDVGLSRGGLPEVLEING-NLLVLTANPLPDRLIAIGDLHGDLEKSKQALRLAGLIDRWFGGSATVVQIGDVLDRGDDELKILYFLEKLKREAVKSGGNLITMNGNHEIMNV---------------EGD---FRYMTKLGLEEFTNWRIAALRPNGPIANRFLSLTVLVVGDSVFVHGGLLAEHVYGLARMNKEVSDWI-TGLRGR----N-AVVWLRKFSDEVDCAALEHVLATIG-----VKRMIMGHTIQAG-INGVCENKAIRIDVGMSRGGLPEVLEING-NLRVLTSNPLPNRLVAIGDLHGDLEKSKQAFRLAGLIDRWSGGSATVVQIGDVLDRGGEELKILYFLEKLKREAVKSGGNLITMNGNHEIMNV---------------ESD---FRYVTKVGLEEFSNWRIAALRPDGPIANKFLSVTVLVIGDSVFVHGGLLAKHVYGLERMNQEVRDWI-TGLRGR----E-AVVWLRKFSDEVDCSALEHVLATIG-----VKRMIMGHTIQAG-INAVCDNRAIRIDVGMSKGGLPEVLEING-KLRVLTSNPWPDRLIAIGDLHGDLEKSKQALRLAGLIDKWAGGSATAVQVGDVLDRGDDEIQILYFLEKLKREAMKDGGNFITMNGNHEIMNI---------------EGD---FRYVTKLGLKEFEDWRIAALRPNGPIANKFLSVTVLVVGDSIFVHGGLLAQHVYGLERINEEVRDWI-SGLRGR----N-AVVWLRKYSDV-DCSMLEHVLATVG-----VKRMIMGHTIQDG-INVACNNRAVRIDVGMSKGGLPEVLEINQ-NLRVLTSNPLPNRLVAIGDLHGDLEKSKQAFRLAGLIDRWCGGSTTVVQIGDVLDRGGEELKILYFLEKLKREAVKSGGQLITLNGNHEIMNI---------------EGD---FRYVTKKALEEFDVWRIAALRPDGPISRRFLALTVLVVGDSVFVHGGLLEKHVYGLQRINDEVRDWI-NGLRGR----N-AVVWLRKFSDEFDCSLLEHVLATIG-----AKRMIMGHTIQIG-INGACDNRAIRIDVGMSKGGLPEVLEIDR-NLRVLTSNPMPDRLIAVGDLHGDLSKSKEALRLAGLIDRWIGGSATVVQIGDVLDRGGDELKILYFLEKLKREAAKDGGMIITMNGNHEIMNV---------------EGD---FRYVTKEGLEEFRAWRIAALHPNGPISGRFLSTTVLVVGESVFVHGGLLPGHVYGLQRINEEVRDWI-KGLRRS----N-AVVWLRKFSDESDCSLLKHVLDTIG-----AKRMIMGHTIQAG-INGVCNNQAIRIDVGMSKGGFPEVLEFVG-NPRILTSNPYPPRLVAIGDLHGDLEKSKEALRLAGLIDRYTGGSATVVQIGDVLDRGGDELKILYFLEKLKREAARRGGRIITMNGNHEIMNV---------------EGD---FRFATLPGVEEFRVWRVAALRPNGPIAKRFLSVTVLVVGDSIFVHGGLLPQHTYGLEKINEEVRDWV-NGSRGA----D-GLVWVRKFSRGDDCSALEHVLSTVG-----VKRMVMGHTIQVG-INGVCDDKAIRIDVGLSKGGLPEVLEISG-SLRILTGNPLPPRLVAIGDLHGDLEKSKEALRLAGLIDRYTGGSATVVQIGDVLDRGGDELKILYFLEKLKREAARRGGRIITMNGNHEIMNV---------------EGD---FRFATLPGVEEFRVWRVAALRPNGPIAKRFLSVTVLVVGDSIFVHGGLLPQHTYGLEKINEEVRDWV-NGSRGA----D-GLVWVRKFSRGDDCSALEHVLSTVG-----VKRMVMGHTIQVG-INGVCDDKAIRIDVGLSKGGLPEVLEISG-SLRILTGNPLPPRLVAVGDLHGDLEKSKQALRLAGLIDRYIGGSATVVQVGDVLDRGGEELKILYFLEKLKREAARSGGRIVTMHGNHEIMNV---------------EGD---FRFATESGVEEFRVWRVAALRPNGPIATRFLSVTVLVVGDSIFVHGGLLPEHSYGLEKINEEVRDWV-KGLRSA----D-GLLWLRKFSRSKDCSALEHVLATVG-----VKRMVMGHSIQVG-INGACDDKAIRIDVGLSKGGLPEVLEISR-NLRILTEDPLPSRLIAIGDLHGDLKKSKEALSIAGLIDNYTGGSATVVQIGDVLDRGGDEIKILYLLEKLKRQAAIHGGNFITMNGNHEIMNA---------------EGD---FRFATKNGVEEFKVWRVAALRPNGPISKRFFTVTVLVVGDSIFVHGGLLKEHVYGLEKINGEVSDWY-KGLRGR----N-ALVWLRKFSD--DCSSLEHVLSTIG-----VKRMIMGHTIQEG-INGVCENKAIRIDVGMSKGGLPEVLEIDR--VRILTSNPLQDRLVAIGDLHGDLEKTKESLRLAKLIDKWVGGSTTVVQIGDVMDRGGDEIKILYYLEKLKREAARCGGTVITMHGNHEIMNV---------------EGD---FRFVTRKGLEEFRVWRIAALRPSGPISSRFLSVAVLVVGDSVFVHGGLLSQHVYGLEKINEEVRDWI-HGLHGA----N-GVVWLRKFSLGLDCSALEHVLATIG-----AKRMIMGHTIQFG-INGVCNERAIRIDVGMSKGGLPEVLEIKG-NMRILTSNPLQDRLVAIGDLHGDLEKTKESLRLAKLVDKWVGGSTTVVQIGDVLDRGGDEIKILYYLEKLKREAARCGGTVITMHGNHEIMNV---------------EGD---FRXVTRKGLDDFRVWRIAALRPSGPISSRFLSVAVLVVGDSVFVHGGLLGQHVYGLEKINEELREWI-HGLRGA----N-SVVWLRKFSHEYDCSALEHVLATIG-----AKRMIMGHTIQFG-INGVCNERAIRIDVGMSKGGLPEVLEIKG-NLRILTSNPLQDRLVAIGDLHGDLEKTKESLRLAKLVDKWVGGSTTVVQIGDVLDRGGDEIKILYYLEKLKREAARCGGTVITMHGNHEIMNV---------------XXD---FRXVTRKGLDDFRVWRIAALRPSGPISSRFLSVAVLVVGDSVFVHGGLLGQHVYGLEKINEELREWI-HGLRGA----N-SVVWLRKFSHEYDCSALEHVLATIG-----AKRMIMGHTIQFG-INGVCNERAIRIDVGMSKGGLPEVLEIKG-NLRILTSNPLQDRLIAIGDLHGDLEKTKESLRLAKLIDKWVGGSSTLVQIGDVFDRGGDELKILYYLEKLRREAARCGGTVITMHGNHEIMNV---------------EGD---FRFATHKGLDEFRGWRVAALRPNGPISSRFLALTVLVVGDSVFVHGGLLAAHVYGLEKINAEVRDWV-HGLRGR----N-AVVWLRNFSHEFDCSALEHVLSTIG-----AKKMIMGHTIQFG-INGVCEERAIRIDVGMSKGGLPEVLEING-NMRILTSNPLPSRLIAIGDLHGDLDKTKQAFHLAGLIDRWSGGSSTVVQVGDVFDRGGDELKILYFLEKLKREAAKSGGELITMNGNHEIMNV---------------EAD---FRFVTRSGLQEFEDWRIAALRPGGPVSTRFLTQTVVVVGDSVFVHGGLLSNHVYGLERINDEVREWL-SGSRGR----D-AVVWLRRFSEEADCSALEHVLATIG-----VKRMIMGHTIQSG-INGICGNKAIRIDVGLSKGGLPEVLEIDGTNLRILTANPLPSRLIAIGDLHGDLEKTKQAFRLAGLIDRWSGGSSTVVQVGDVFDRGGDELKILYFLEKLKREAAKSGGELITMNGNHEIMNV---------------EAD---FRFVTRSGLQEFEDWRIAALRPGGPVSTRFLTQTVVVVGDSVFVHGGLLSNHVYGLERINDEVREWL-SGSKGR----D-AVVWLRKFSEEADCSALEHVLATIG-----VKRMIMGHTIQGG-INGICENRAIRIDVGLSKGGLPEVLEIDGTNVRILTANPLPDRLIAIGDVHGDLEKTKEAFRIGGLIDRWIGGSTTVVQVGDVLDRGGEEIQILYFLEKLKREAARSGGKIITMNGNHELLNV---------------DGN---FKFTTADSLKEFKKWRIAALRPGGPITRRFLSATVLVIGDSIFVHGGLSSKHLYGLDRINEEVKDWM-NGL-GE----D-GVVWMRKFSVKKDCSALEHLLTTVG-----VQRMIMGHTPQ-R-INDECDGKAIRIDVGMSRGRLPEVLEITR-GLKILSSSPAPDRLIAVGDLHGDLQKSKEALRLAALIDRWTGRTATVVQIGDVLDRGGDELKILYFLEKLKREAEKSGGTIITMNGNHEIMNV---------------DGD---FRFVTQAGLDEFRVWRIAALRPEGPISVRFLSQTVVVVGDSVFVHGGLLPKHVYGLERINEEVRDWI-NGLRGK----H-SMVWLRKFSHELDCSTLEHVLATIG-----AKRMIMGHTIQTG-INGACGNRAIRIDVEADR----------------------PNRLVAIGDLHGDLDKSKQAFKIAGLIHRWIGGNTTVVQIGDVFDRGDDELKILYFLEKLKREALRSGGSIITMIGNHEIMNI---------------DGD---FRYITPSGLQEFKAWRIAALRPNGPISTRFLSPTALVVGDSVFVHGGLLQDHVYGLERINEEVRDWI-NGLRGR----N-SVVWLRKFSDQVDCSTLQHVLATIG-----AKRMIMGHTIQMG-INGVCDNQAIRIDVGMSKGGLPEVLEIIG-NVRILTSEKVPSRLIAIGDLHGDLPKAKQALRLAGLVGRWSGGSATVVQVGDIFDRGGDEIKLLYFFEKLKREAAGAGGLVITMNGNHEIMNV---------------EGD---FRFAAREGFEEFENWRIAALRPNGLISSRFLSQTVVVVGDSVFAHGGLLQNHVYGLDLINEEVRDWI-LGLRGR----D-SIVWLRSFSNELDCSMLEHVLETIG-----VKRMIMGHTIQNG-INTVCGNRAVRIDVGMSRLRFPEVLEIGE-NLKVLTSNPLPSRLVAIGDLHGDLAKSLAALRLAGLLPSWAAGPTLAVQLGDILDRGGDELRLLYFLRRLSISAAAQGGALLPILGNHEVMNV---------------AGD---YRFVTPEGLREFSAWRLAALRPEGPIARRFLAPTVLVVGDSVFVHGGLLEAHVYGIERINAEVSDWI-RGGSGR----D-AVVWLRRFSEGFDCQRLQGVLGMLG-----TKRMVMGHTIQEG-INAVCGAQAVRVDVGLSRGGLPEVLEINGGGVRVITTDPAPTRLVAIGDLHGDLPKSLSALRLAGLVPSWSAGPTLAVQLGDILDRGGDEIRLLYLIRRLAISAAGQGGALLPIMGNHEVMNV---------------SGD---FRFATPQGLREFSAWRLAALLPDGPIARRFLAPTVLVVGDSVFVHGGLLEANVYGLERINAEVSEWI-RGERGR----D-AVVWLRRFSDGVDCQRLEGVLGMIG-----AKRMIMGHTIQEG-INAVCGAQAVRVDVGLSRGGLPEVLEINGGGVRVITTDPAPSRLVAIGDLHGDLPKSLSALRLAGLVPSWAAGPTLAVQLGDILDRGGDELRLLYLLRRLALSAEARGGALLPILGNHEVMNV---------------SGD---FRFATPQGLQEFSAWRLAALRPDGPIARRFLAPTVLVVGDSVFVHGGLLEANVYGLERINAEVSEWI-RGERGR----D-AVVWLRRFSDGFDCQKLEGVLGMIG-----AKRMVMGHTIQVG-INAVCGAQAVRVDVGLSKGGLPEVLEINGGGVRVITTPPSPSRLVAIGDLHGDLPKSLSALRLAGLVPSWAAGPTLAVQLGDILDRGGDELRLLYLLRRLALSAEARGGALLPILGNHEVMNV---------------SGD---FRFATPQGFQEFSAWRLAALRPDGPIARRFLAPTVLVVGDSVFVHGGLLEANVYGLERINAEVSEWI-RGERGR----D-AVVWLRRFSDGFDCQRLEGVLGMIG-----AKRMVMGHTIQVG-INAVCGAQAVRVDVGLSRGGLPEVLEINGGGVRVITTPPSPSRLVAIGDLHGDLPKSLSALRLAGLVPSWAAGPTLAVQLGDILDRGGDELRLLYLLRRLALSAEARGGAFLPILGNHEVMNV---------------SGD---FRFATPQGLQEFSAWRLAALRPDGPIARRFLAPTVLVVGDSVFVHGGLLEANVYGLERINAEVSEWI-RGERGR----D-AVVWLRRFSDGFDCKRLEGVLGMIG-----ARRMVMGHTIQVG-INAVCSAQAVRVDVGLSRGGLPEVLEINAGGVRVITTPPSLSRLVAIGDLHGDLPKSLSALRLAGLVPSWAAGPTLAVQLGDILDRGGDELRLLYLLRRLSLSAESRGGAFLPILGNHEVMNV---------------SGD---FRFATPQGFQEFSAWRLAALRPDGPIARRFLAPTVLVVGDSVFVHGGLLEANVYGLERINAEVSEWI-RGERGR----D-AVVWLRRFSDGFDCKRLEGVLGMIG-----AKRMVMGHTIQVG-INAVCSAQAVRVDVGLSRGGLPEVLEINAGGVRVITTPPSPKRLIAVGDIHGDLAKARAALHVAEVIDHWIGGETVVVQVGDLLDRGGEEIKVIYLLEKLRGEAQKVGGNVHIMNGNHEIMNI---------------EGD---FRYATPLGLDEFQRWRIAALRPGGPLASRFLAPTVLVVGSSVFVHGGLLPVHVHGLERINQEVSEWM-LGTHGG----N-ALVWLRKYSDVKDCDLLKRCLGSIG-----AKRMVVGHTIQIG-LNGACDNKVIRVDVGLSKGGMPQVLEIRG-DLRILSSRLPVERLVAIGDIHGDLAKTRESLRIAGVVDRWIGGKTVVVQVGDVLDRGGQELKVLYLLERLKGEAQRHGGDLHIMNGNHEVMNI---------------EGD---FRYATKEALDEFSAWRYAALRPGGPISSRFLAPTILIVGSTVFAHGGILPSHLYGLEKINAEVRDWI-QGRRGK----D-AVVWARQYSIPVDCKLLDEVLTGIG-----ASRMVVGHTIQFG-INSACQNQVFRVDVGMSSGTAPEVLEIRH-DVRVLS----VRRLVAVGDLHGDLAKTKEALVAGGLMDRWSGGTTTAVQVGDQLDRGGDEVAILLLLERLRKEARDAGGELVVMNGNHETLNV---------------AGR---FRYATADGLEDFRRWRLAALAPGGPMARRFLAPLVVAVGSTVFAHGGVLPHHVYGLERINKETSDWV-RGNSGR----E-SVVWARDYSMPEDCDVLEASLSKMG-----MKRVVVGHTIQHG-VNAACDGKVLRVDVGMSKGGKPEVLEILDDGGVFRLSLDE-ERLVAIGDLHGDLNKATRAFRAGGLIDKWIGGATVAVQVGDQLDRGGDEVAILYMLERLRKEARDAGGELIVMNGNHETLNV---------------AGR---FRYAFEPGIEDFRRWRLAALAPGGPMAKRFLAPVVVAVGSTLFAHGGVLPHHVYGLERINQETSEWI-RGDSGG----R-SVVWARDYSWPQDCGVLRRALDGLG-----IDRVVVGHTIQEG-VNAACDGRVLRVDVGMSEGSEPEVLEIL------------VERLVAIGDVHGDLAKTREAFRAAKLTNEWVGGTTTCVQVGDQLDRGKDEVAILHFLERLRGEARAAGGELVVMNGNHETLNV---------------SGR---YRYSLAEGNADFTRWRWRALAPGAPLALRFLAPVVVAIGSTLFVHGGVLPEHVYGLDTLNEEISQWI-KRGQGR----D-SVVWARDYSHVQDCDLLEETLRMIG-----VERVVVGHTIQHG-ITSACDGKVIRIDVGMSKGAKPEALEILKDGIAKMKLGDDVERLVAIGDVHGDLSKVREAFRAAGMTNEWVGGSATCVQVGDQLDRGKDEVAILHFLERLRGEARDAGGELVVMNGNHETLNV---------------SGR---FRYSLPEGRADFARWRWRALAPGSPMTMRFLAPVVVAIGSTLFVHGGVLPEHVYGLDTLNAEISAWM-QRGQGR----D-SLVWARDYSHVQDCDLLKETLAMIG-----IERVVVGHTIQYG-ITKACDGQVIRIDVGMSKGAKPEALEILNDGI--------VERLVAIGDVHGDLDKTREAFRAARLTNEWIGGTATCVQVGDQLDRGKDEVAILHFLERLRTEARNAGGELIVMNGNHETLNV---------------AGR---YRYALTEGSADFARWRWRALAPGAPLTLRFLAPVVVAVGSTLFVHGGILPEHVYGLDSLNAEISTWM-KMGQGR----D-SLVWARDYSHVQDCDLLKETLKMIG-----VERIVVGHTIQHG-ITSACDGKVIRVDVGMSKGAKPEALEILRDGLTKLKVGADVPRLVAIGDLHGDLKKARRAFRLGGLTDRWIGGTTTAVQVGDQLDRGNDEVRILYFLERLEREAERAGGKLHILNGNHETMNV---------------AGR---FNYATLPGLADFYHHSEALHCSAGAVTARFLAPIALQIGSTVFVHGGVLPQHALGLERINQETRAWM-RGETGR----Q-AIVWAREYSAGADCAALEQVLGRLG-----AERMVVGHTIQAG-INSACEDRVFRIDVGLSKGGEPQV----------------VPRLVAIGDLHGDLRKARRAFRLAGLIDRWAGGTTTV--VGDLLDRGDQELPLLFFLERLQGQAAAAGGALHVLNGNHETMNV---------------AGQ---FRYVTHRGMHSFADWRILALQPGGEVTRRFLAPVVLQVGSTLFVHGGVLRQHVYGLERINRETQEWMLKGSSGR----G-AVVWSRHYSAAADCGQLAEVLGRVG-----AQRMVVGHTIQGG-INSACQGRVLRIDVGLSRGGSPEVLEIVN-DVRRLSESQQPPRLVAIGDIHGDYHKAVRALRLAGLMDRWAGGSTVAVQVGDILDRGDHEIRILILLERLAAEAAAAGGRLYLLNGNHETMNV---------------MGD---HRYATPGANLEFLGFR--ALMPGSELARRFFAPTVLQLGGNVFVHGGVLPAHVYGLEKINSETQSWM-LAPRGG----S-AIVWARAFSASDDCDTLKSVLESVG-----AQRMVVGHTIQRG-INSACESRVVRVDVGMSHGGPVEVLEVLK-DVLRLREHTPADRLVAIGDIHGDYHKAVRAFRLAGLTDRWSGGSTVAVQVGDILDRGDHEIRTLIMLERLAREAEAAGGRLYLLNGNHETMNV---------------MGD---HRYATPGANLEVLGLR--ALRPGSEISRRFFAPTVLQVGDNLFVHGGVLPAHVYGLERINRETQSWL-LGGLGG----S-AIVWARAFSASDDCETLQNVLESIG-----ARRMVVGHTIQRG-INSACESRVIRIDVGMSHGFPVEVLEVLK-DVRRLREHGP-----------------------------------------------------------------------------------------------------------------------CLTVLRPDGPISRRFMAPTVLVVGDSVFVHGGLLEANVYGLERINAEVSEWI-RGERGW----D-IVVWLRRFSDGFDCKRLEGVLGMIG-----AKRMVMGHTIQVG-INTVGRGPPPSTSVSVGRGAMAQTLATVG---RTLPQRGG-----------------------------------------------------------------------------------------------------------------------RLTALRPDGPISRRFLAPTVLVVGDSVFIHGGLLEANIYGLERINAEVSEWI-RGERGR----D-TVVWLRRFFDGFDCKRLEGVLGMIG-----AKRMVMGHTIQVE-INTVGRGPPPSTSVSVGRGAMAQTLATTG---RTLPQRGG-----------------------------------------------------------------------------------------------------------------------RLTALRPDGPISRRFLAPTVLVVGDSVFIHGGLLEANIYGLERINAEVSEWI-RGERGR----D-TVVWLRRFFDGFDCKRLEGVLGMIG-----AKRMVMGHTIQVE-INTVGRGPPPSTSVSVGRGAMAQTLATTG---RTLPQRGGVRRLLALGDVHGDLASLRKCLSLANVINEWIGGDAVVVQVGDVFDRGDAERAVLHFLDTLDRQARERGGAVYRLLGNHEVMNV---------------DLD---FRYVTPGGFAEFRRRRAMALAPGCPTARLLAEQLVLIIGDTLFVHGGLRPDHVYGLERLNAETRAWMERRAKGS----R-SPVWMRTYSAPHACRELEETLRRAG-----VRRMVVGHTPQ--VINGACRGRVWRVDTGMSAAGACEVLEISETHIRIFTDHGVPGRVVALGDLHGDAAAAVTALTAAGLIDHWSGGDATLVQLGDVLDRGGEEFALWGLLERLRLEARSAGGRVVTLLGNHEVLNA---------------LGKA--ATYVHPAGHAQFGDDRCAAFRPGGALAARLADPVVAVVGDSVFAHASLPRGATGSLARLNAETRAWL-LGEGGR----D-SPVWDRTFSAPGDCEALRDTLRGLG-----ASRLVVGHTPQ--RVNGACGGAVWRCDTGCSRWGPVEALEIQGGAVRVLRRGTAPKRIVAVGDLHGDIHATRQALRLAGVLHEWIGGDTFLVQVGDQVDRGDDEIQVMSLLHRLGKQARAEGGRVEVLVGNHELMSA---------------QGN---FRYATKGAMRNFQRWRYLSLRSGGTFASKFLAKAILIVGDTVFVHAGLLHKHFEAINVLNQEVAAFL-KGEWGN----D-GILWTRRFSKIDTCKQLKKTLNRLN-----VRRMVVGHSVQDG-ISPACDASVWRIDVGMSKGTSPQVLEIKQDGVNILGKSIEPDRLVAIGDLHGDIVATRRALRLAEVLHEWVGGKTVVVQVGDQLDRGDDELQILSLLRKLAVQARQHEGALHVLIGNHEILS----------------THT---ARYATRGALENFFRWRYMALHPGGMISRTILATTALIVGQTLFVHAGIDLDHIEALKKINEEVSAFF-RGESTP----D-SMVWMRRYGGTHTCATLNATLKALD-----VRRMVIGHTIQSKTINSACDGAVWRVDIGMSSGTEPQILEMWKNGVNVKKEAAMNQRLICIGDVHGDLWALQDFLEISGVYDEWIGGNTIVVQCGDILDRGVEELACYKLLCKLSQQAIHTDGKVILLVGNHEAMNS---------------MGL---FQYAINDLEHERKIGRWSSYEPGGLLATSLLAKVAIRVGRTVCVHAGLRPSHLGGIEGMNKQFRDWITLET---------GPIWMRDYSYPHTTRMIEETLLLLD-----CDRMIMGHTIQ--QINCVLHGRAWRIDVGASRGGTPE-IKIKYRY---------NQRIVSFGDVHGDITALRTFLITARVLDRWSGGDTICVQTGDVLDRGDDELACFRLLATLSRQAKESGGALLLLYGNHESLNA---------------AGL---FQYANPGGNAEFESTRWASFEPGGLLAENMLGLVACVVGRTVFVHAGLQAVHLNGISKLNMEARDWILKDCIGA----S-SPVWMRDYSQPNKNPYAKTMIGTLN-----VQRMVMGHTPQ---INAAMNGRAWRIDVGASQGGTPEVLEI-------------AERLVVIGDVHGDIDAFRSCLQMADLVDKWAGGETVVVQMGDIFDRGDDDLPIQEWVYKLAQEAGRANGALYSVMGNHEMLNA---------------MGD---HSMATRKAFVPFLALRLAAMRPGGPVA-RLMAAVSMKVGDNLFVHAGLLPEHIGGMERLNADTCAWM-LGKWQP----E-GPLWTRVYSTPDARAQLEEVLRLTG-----TKRMVVGHTPQAG-INSAADGQVWRVDTGMTAMGRPEALEIRGEEMTILTEYKS--MIPFIGNRVLD--AFAETLLAAGLVDNWAAGETVLVQAGDVFDRGDADLEVEEWLWTLQEQATESGGAVYHLLGNHEIMNA---------------MGD---HSTASPNSFKPFQDLRLAAMAPGGPVS-KMLASVAMKIGDTLLVHGGLRPVN-FDLESLNRWTHEWL-VGQWNR----D-SPVWTRFYSSPGAEADLQKVLDATG-----TVRMIVGHTPQAG-INSALGGRLWRTDTGMTAMGQPEALEIVDGVATIITAGGKAERIIAIGDVHGDVDALHECLKVANLVDNWIGGAAHLVQVGDILDRGMEERRCLQSLLDLKQKAADAGGAVHVLLGNHEVMNV---------------DLD---FRYVSPRENAWFGWERVYAFRPGGGAA-RCLSPIAIQIGDSVFVHGGLRLQHVYGLEKLNQETAAWL-YGSDDI----N-SPIWSRIYSVPSAELELEQVLEKLN-----AKRMVVGHTPQRG-INAFVGYEVWRTDTGMSQGGPIECLEILEDGVHVLTQAGIPKRIIALGDIHGDVRALATSLHMSHLIDNWIGKDSVLVQLGDVLDRGPNDYWCMRLLIKLQEQARASGGDVICLLGNHEVMNV---------------QLD---FRYVDPAAWAGWELERVNALRRGGTLS-KTLSPVCVVIGDTVFCHGGLMPEAVYGLQRLNDETSNWL-AGENP-----QFSPIWHRAFATANTLSAADCTMRLLH-----VSRMVIGHTPQEG-VNCLVGREIWRVDAGMSTGGPVECLEILAAKVNILSEDGVAARIIAIGDVHGGFNELHHALKISGCADRWTGGDTVVVQMGDFLDRGSDESRSIEMLRDLKVQAKDAGGDVITLLGNHEIMNA---------------DLD---FSYAP--DIYSFDSWRAQLMQRGGKLA-MLMSPVVVQIGDNVFVHGGLTRETIHGIDKLNQEVADWLRKDADPPKGGRTVSPLWERVYGMPIALETLDGMLESMD-----AKRMIVGHTPQYGGVGTEKEKEVWRIDTNLNDKGRVECLEILTDLVRVLSEDGRARRIIAIGDL--------ASLRLAGVIDKWIGGDTVVVQVGDVLDRGDEESAVYDLLRRLASSAARKGGAVHMLLGNHEVMNV---------------GWD---FRYCEMYEKVDGDCPERGGDRPGGPVARK-LGNTVLVIGENVFVHAGLHGRHVYGLERINREVRDWM-RGT---------DPDATKPACVT-NCAKL--TLEDIP-----AKRMIVGHTDN-G-INCACSGAVWRLDVGMSRVAAAEVLEIRGDTVTALRRGVRTDRVVAIGDVHGDLEALRSCLRLSGLVDAWVAAGATLVSCGDVLDRGDGDWDCLTYLADLKTRATDAGGDVHLVLGNHEVLNV---------------LGD---VRFASRGALVRC---RKRAFAPGSGEGARLLAPVARVCGDTLFCHGGLHAR--GGLDALNGDAARWL-GGAPSP----S-SPVWSRSYSHPAQCGDARSALDALG-----CARMVVGHTPQQG-INACCDDSVFRIDTGLSAYGPKEVLELRPGR---------EPRLVAFGDIHGDVFRCRQILQLANITDRWIAGSSIVVQLGDIADRGLHPHEIYDLFASLERQAMKAGGEFIFLVGNHELMNI---------------LGI---FYYVHPDVMSAFGGEYAAAFGPEGPYGLYILQPVTVVREGVVFAHAGITPEYAKGVEGINAELMNGF-RGESNS----S-SPLWSRAVLDE-NCSLLMESLRLLP-----VRVMVGGHTVQGGVMAVECNGSLVGADVGLSRFGYVAYVEFLLDD---------VHRIIAVGDVHGDADNFLKILRIANLIERWTSVRTTLVQVGDLIDRGEQDLEALNIAISLQEQTAQSGDEVVLLIGNHELLNI---------------QGH---YHYVNKHNYGGFLSKRAEGMKATGAFGKYIVDKAAHMDEGVLFIHAGIETSMNKDVEALNADVREALRQGILGS----S-GPLWTRKMIIE-ECSDVRAALKQLN-----ATRIVVGHTPQSGHIGQHCDGQVLAIDVGMSRWDKVAALELVFSK---------IHRIVAVGDVHGDAERFRQILEMSGVISRWTRLRTTLIQTGDLIDRGEEDLEVLEMAVSLFNEVRTNYDKVVLLMGNHELLNL---------------QGH---FHYVHSKSMGGFLTRRKRAFELDGTFGGFILETVAYAVADTLFVHAGIDEHVVDGIERLNREAKQAIRTKNLGS----T-GPLWSRKMFLD-RCADTKKALASLG-----VKRVVVGHTPQSGRVETFCGGSVIAIDVGMSRWGNIAALEITVTS---------IHRIIAVGDVHGDTENFRQILSMAGIVSMWTKLRSTLIQMGDLIDRGEDDLGVLEMAFSLFEQVKSNHDNIVLLLGNHELLNL---------------QEQ---FYYVHPETMGGFLSKRKRAFEPSGTFGRFLLDNVLYFDAETVFVHAGIDQRFAVGVEMLNKKTMQAIREKDLGT----S-GPLWTRKMITD-RCTGIQKMLSFIG-----AKRIVVGHTPQSGHVEVFCNDSVIAIDVGLSRWGNLAALELMVTS---------HSRLVLLPDLHGDARQAARALQLAGLISQWTGGDAMLVQLGDVVDRGHDSLALLGLLQRLGQAAEAAGGRVQAILGNHELMLV---------------HHD---YRYVSREELRAIGAAWQAGLAPSQPLGALVRRPLALLAKGVLVVHAGAFPWMRAGVDAWNAVALEALVHCDLGG----E-GAVWSRRYIQA-VCAEVAAVAERLG-----VQRVVVGHTVQGGRVSSRCGGQLLMVDVGLSRAGEMAVLTCSNGV---------PSRLVVLPDIHGDGPQALRALHLAGLISQWSGGDTVLVQLGDMVDRGPDSLALLTWLESLRGQARATGGDVVALLGNHELMNI---------------HHD---FRYVAPAEIVALAEAWREALAADAPLGSLVRQPLAALIDAVLAVHAGAFPWMLGGVAAWNAATAGALRFCELGE------GAVWSRHLAHGPVCLEVAAVVSRLR-----VERLLVGHTIQGGRVSSRCGGQLLLADVGISRAGEMAVLQCSSGKTDRQTEEEQFARIVAIPDIHGDLHHYRQSLRLAGVVDEWTAGSTHLVQTGDVVDRGQHSLLIMDMLANLTVRAKRVGGKVTALMGNHELMSL---------------MDD---TRYVHKDEILLLGTKWHRSFDPDAKQGRRLRRPLATVAGSSLFSHAGVRSRHLGGVDAMNEAAAAAI-QGKYDN----E-SPVWNRFYSREDVCDEVNRVLTAAR-----ANRMVIGHTVQGG-MRTKCGGKLHLIDVGMSSAGRGAAWVCEGGETELLEKEADARRLVALPDLHGDLDLARRSLILARVINAWSGGETILVQTGDVLDRGDASVALMRLLNKLARAAKDAGGEVVGLLGNHELMTL---------------QGD---LRYVSKRELVKLGKAWRDLFRAGADLGETLRFSMLHVAGESLFSHAGIRAHHL---EGVNGALRAASAGDGAFG----D-GPLWNRFWSTPRVCDELGAVLAKVG-----ARRMVIGHTIQRG-MATRCGGGLHLIDVGVSGKGRPAAWACEEGVVEVLDDGVE-------------MF---EALALAGVTRGWGAGRATCVQTGDLVDRGERSIEAVDEVERLTREANAVGDEFVSLLGNHELMTL---------------QGD---HRFASRDELTALGRSWRQTFAKGSTRGDVLREPWAAVRGRTAFSHAGLLPEHLFGVDELNARGAKLLAVDELLD----R-GPMWTRTISMG-ACALAAEVIRRLG-----VRRMVVGHTVTSGKIETRCDGLIHMIDVGMSKAGSPSVWMCTESESRVPLEN--RRKRLA------------VGRRLAGVVDSWGGGATTVVQTGDATDRGARSIETIDAIERLRVEAKEVGDEVVGLLGNHELMTL---------------QGD---YRFVAREELLALGRRWGKMFARGSERGEVVREPWAVVRGRTAFAHAGLLPEHLLGVDALNAEGKRLLAVECLVG----D-GPVWTREISTG-ACDAALEVTRRLG-----VRRLVVGHTVTSGRIETRCDGLIHMIDVGMSRLGSPSAWTCVESQGERVALE-----------------------------------------------------------MDLGVRALREGGT----------------------------TGD------------------WMRAFARGSARGDEVRSPVAVTRGETVFVHAGLTSRHLFGVDALNARARELFDVDVTGG----D-GPLWTREISMG-VCKEVEETLARLN-----VKRMVVGHTPTSGSIETRCEGMVHMIDVGMSSAGVPSVWMCTESEGERVALE--LKRIVAVADVHGDRRNLMQALENGRVLVEWVMEGTQVVQLGDLVDRGPLGLQCYRLMQDLY--VAEGANEVVRVLGNHEVLNL---------------LGMA--GRYVTDEDVAEFGGERRESWSPGGEIWTILKDELVHVYGGHRFVHGGVMPALTRSIDELNEQASRMIKNGALS-----ESSPLWSRVYALG-ACPPLLNVLRHYG-----VARMVVGHTPSDGRMKVRCGGRAILADVALSRWGHPAALEMTLVN---------LKRIVAVADVHGDRRNLMQALENGRVLVEWVMEGTQVVQLGDLVDRGPLGLQCYRLMQDLY--VAEGANEVVRVLGNHEVLNL---------------LGMA--GRYVTDEDVAEFGGERRESWSPGGEIWTILKDELVHVYGGTLFVHGGVMPALTRSIDELNEQATRMIRDGALS-----ESSPLWSRVYALG-ACPPLLNVLRHYG-----VARMVVGHTPSDGRMKVRCGGRAILADVALSRWGHPAALEMTLVN---------PSRLVAIGDLHGDLPKSLSVLRLAGLVPSWPAGPTLAVQLGDILNRSDDELRLLYLLHRLSLSAETRGGAFLPILGNHEVMNV---------------SGD---FRFATPQGFHDRAVCKLPAFLPGGFLASNQTSQRLIKV---LFVHSGLLMKNRSDLEEYIQETGRAGRDGRLSCHLFLDSTTFYKSEYAMSKICSLVKESTSRKV-----LTQLEIGHLQQSGEISFGCGGRYLEVDPVVMEAAKAELVKLVGKG---------PSRLVAIGDLHGDLPKSLSALRLVGLVPSWTAGPTLTVQLGDILDRGGDELRLLYLL-RLSLSAETRGGAFLPILGNHEVKNV---------------SSD---FRFATPQGFHDRAVNRGGGLDPSRLCACAGFAGAVLIVSRDFNLHQAFKFECAYAYTEENTKPGKYI------TKPRTNNSLIW--------KCDQVLS-----------NNLFGLGYAIQ--------ERRVERASVCVTT----------------------PSSVCAVGDLHGDLQHALAALALCGAVDSWVGGAMTVVQTGDVLDRGNNSLGVLRALWRLQAEAEAAGGELVLLLGNHELMNM---------------QGK---VHYVHKAELAAEGGAWKRRMQPTGDLGAALLRDAAAVRGGTLFVHAGVRLSVAFGVERLNEA-----------------------------------------------------VGHNIV--WVSSRCGGTLALLDVGMSSAGLPAACDVGEEGYHGAATRGPARRLVAVGDLHGDYEQTVSVLRLTRLIDHWIGEDALLVQLGDILDVGPDDILIVRLLMRLQQEAHAKGGDVIELLGNHELRNF---------------RGD---YKAVDKASLAASGGQRDVLLSNATDLGRY-LRKAVFHYGPFLFMHGGFSTATATSVEQFNSELTKALLNGTEDDVDDVA-NPILVRSILTV-KCNALSKVLDKKG-----IQSVVVGHVPHPRDFDGLCGGRLIDIDFGMSRWGHVAALEIEEATVQLIETSTAGRQIVVVGDLHGDLNQTLAILKITGLVDHWIGGDSFFVQLGDIFDVGPDDISIVKLLMKLEKEAQSVGGDVIELLGNHEIRNL---------------LGD---YSAVDPGSLAGSGGVRDRLLSNRTSVGMY-LRKAIFHHNEFLFMHGGLSTATATGIHEFNKDLRKALTNGTEGGGQEVV-NPILVRSILNV-RCKDLIKVLQNKG-----IKSVVVGHVPHHQDFKDLCGGHLIAIDFGLSRWGHVAALQIDDTTVQLLESTVRGRRIVAVGDLHGDLNQTLSILHLAGLVNHWIGKDTYFVQLGDILDVGPDDLMIVRLLMRLEKEAQAEGGDVIQILGNHEIRNL---------------LGD---FSAVDPVSLAQSGGKRRELLSNRTPLGIY-LRRAIFHHKEFLFMHGGLSTATGTGVEEFNKALRDTLINNTENEAKKVA-NPILVRSILNV-RCSELEKVLSKKG-----IKSVVVGHVPHTDDFSDLCGGRLIAIDFGLSRWGHVAALEWDDVSVQLMESTGKNQRIIAIGDLHGDIDRLRSTLRAANVLEAWRKGTDVVVQLGNVVGYGPDAPEMLQLLSGLKPQALASGGRLITLSGNQELLTL---------------SGV---LEYVHPRQLNLSAGYLRYLYGPGGRYGRMMAELAVAIVSDIVFVHGGLTAAYARGVNKLNAE---WY-EGAHDE----E-SPLWDHSVVRA-NCGPLSAGMAALD-----INLMVVGHTTMDGKVGTWCAGKLMTIDVAMSRYGGYEAFVSFLPMLVLGTAERVVEKLIAISDIEGNFEAFRRFLLSHKVIDNWIFGKGHLVCVGDFFDRGANVTECLWLIYDLEEKAKAAGGYVHFILGNHEIMNM---------------SND---YRYVSPKYMRNADLYYGNWFKSSTELG-RWLGNVVEKIGDMIFVHGGLAPDLNKTLIDINNAMRPFYFIQEFDA----N-GPLWNRSYVMANPESDVAESLRKFG-----GKRIIVGHTLV--HAKMLYGGKVIAIDTRHVDPNSTALFFEDGKL---------PKQIFVLSDIEGNFKSLFLLLRNYKIIDKWSFKDNHLVILGDCFDRGEEVMECLWLIYSLEERAQRDGGHVHFILGNHEIMNM---------------NGD---WRYIHPKYAITPSGSATALYDGNSELW-RWLRNIIEQIGDILFVHGGISEALLLSVTEINELARPYYTRANNS-----DESPFWYRGYYRAASEGQVDTILKKFD-----AKMIITGHTIV--KVTSFFNGKIINVDTNHAAGVSEALFIKGNNF---------PEKLIAISDIEGNFDAFCGFLQKNKIIDNWVFGKGHLVLNGDFVDRGQHVTPTLWLIYKLEEQALQQGGKIHYVLGNHEIMNF---------------QGN---HKYADAKYIKLAQIIYKILYSKKSEIG-RWLRNVVTKIGDYLFVHAGFSPEILLSLENINEITRKNWDKDLLG-----RKGPFWYRGLVKSYNAKDVQEILKTYQ-----AEKIVVGHSIV--AVSADYHGKVIRIDVKHGNE-QGLLVENGIEY---------IKKVVALSDVHGQFDVLITLLTNQKIIDNWAFGNGHMVMTGDIFDRGHQVNEVLWFMYKLDQQARDAGGMVHLLMGNHEQMVL---------------GGD---LRYVHKRYDVAAKLLYDKLYGADTEIG-QWLRNTIIKINDVLYMHGGISSEWILTLARANKLYRQHVDASKFFG----N-GPTWYRGYFSEETETELDTILNHFD-----VKRIVVGHTSQ--RILGLFNNKVIAVDTSIKKGGELLLLENKQLT---------IKKVVALSDVHGQYDILITLLRNQNIIDNWAFGDGHMVMTGDMFDRGHQVNEVLWFMYQLDQQAIEAGGKLHLLMGNHEQMVM---------------RGD---LRYVHERYQVAAKLLYDELYDKSSEIG-QWLRHTLVKINDTLFLHGGISGEWLLTLDVANDLYRKNIDRSKFFG----N-GPTWYRGYFKPGDEAELDKILSYFD-----VKHIVVGHTSQ--RVLGLYNNKVIAVDSSIKEGGELLLMEDNTLT---------AGKIVALSDVHGQFDVMINLLKAHKIIDHWAFGDGHMVMTGDMFDRGHQVNEVLWFLYELDKEAQAAGGRLHLLMGNHEQMVF---------------RGD---LRYINERYKTSAELLYDALYNKDTEIG-RWLRNTLVKINNLLFMHGGISPEWVLNISDANQLFRQHLDDKKFFT----N-GPTWYRGYFKDASEQEIDQILSYFK-----VDHIIVGHTSQ--RVLGLYHNKIIAIDSSIKNGGELLLIDKDKLT---------VSKIVALSDVHGQFDVMINLLKAHKIIDHWAFDDGHMVMTGDMFDRGHQVNEVLWFLYALDQEAQAAGGRLHLLMGNHEQMVF---------------RGD---LRYVNERYQVSADLLYDALYNKDTEIG-QWLRHSLVKIINILFMHGGISPEWVLHISEANQLFRQHLDDKKFFT----N-GPTWYRGYFKDEKESDIDSILSYFK-----VEHIVVGHTSQ--QVLGLYHNKIIAIDSSIKNGGELLLIDAGKLS---------PEKTFVLSDPHANWSCFASLLKAGKVIDNWIFGTNQLVIIGDVFDRGVDVLPIYWLIYKLEKEAEDAGGKVTFLIGNHETMVL---------------GND---LRYTKKKYTQLADTLYPELWQK-SELG-HWLKNSIQVVGDNLFVHAGLSKEFLYDIPTVNEIVSDGLFLTKFA-----TYGPIWYRGMVRSADRDDLRKILEKYN-----VNRIFVGHTIF--DITTFYHYKVIAVNVDNQENGRGVMIEKDGSM---------ADKVFVMSDPHGRLDCVISLLQGNHIIDKWSFGKNHLMIIGDIFDRGKDVPQIFWLFYKLEEEAAKAGGHVSFILGNHEPMVL---------------AND---LRYTKEKYKILAEKLYPRLFGPDTELG-RWLGNTMQMIGNDLYVHAGLGKDFYLSIPTVNEEMSKGLFMTKYG-----NSGPIWYRGLVRTDAKDSLEMIMDRYK-----AKHIIVGHTIF--DISTFYNGKVIGVNVDNKENGRAMLIENNQYF---------NGKIIAIGDIHGDIESLKLILRHSKLIGNWIGDNVLLVQNGDVFDRGIYGPIIYNFLFKLQKEAIKKNSRVILIMGNHEQLNL---------------CGY---FNYVNPKEIEMFFHNRYHSFVNPGEYHKRLIRPPMVKVNNIIFTHGGLNLLISLSINDINLKTRLQIENNCLS-----RDGVLWSDAMSRNVKCSELFQILDKYD-----AKYLVVGHTRQSHQIGSYCNNHYFLIDTGMSLFPYPNYLKIDDHK---------NGKIIAIGDIHGDIESLKLILRHSKLIDNWIGNNVLLVQNGDVFDRGIYGPIIYNFLFKLQKEAIKKNSRVILIMGNHEQLNL---------------CGY---FNYVNPKEIEMFFYNRYHSFVNPGEYHKRLIRPPMVKVNNIIFTHGGLNLLISFSINDINLKTRLQIENKCLS-----RDGVLWSDAISRSVKCSELFQILDKYD-----AKYLVVGHTRQSHQIGSYCNNHYFLIDTGMSLFPYPNYLKIDDHKPSHQIGSYCNGKIIAIGDLHGDIDSLKLILRHSELIDNWIGDNVLLVQNGDVFDRGIYGPIIYSFLFKLQKEAVKKNSRVILIMGNHEQLNL---------------CGS---FHYVNPMETKIFFDNRYYSFVSPGAYHKRLIRPPMVKVNNIIFTHGGLNSLISFSINDINLKTRLQIENNCLS-----RDGVLWSDVISRSVRCSELFHILDKYD-----AKYLVVGHTRQSHKIGSYCNNHYFLIDTGMSLFPYPSYLKIDDNK---------EGKIIAIGDIHGDIESLKLILRHANLINEWVAENVLLVQVGDVLDRGIYGPLIYDYLFKLQKEAPLKKSKVLLIMGNHEQLNL---------------CGY---FDYVNEKEVEVFFKKRLFHFVYSGEYFKKLIRPAIAKVNDILFVHAGISTQISLSLNTIRLKTRLQIENMCVS-----REGVLWHDHISRTAACSILSQIFNNYK-----AKHLVVGHTRQTHEISSYCNGGFFLIDTGMSLFPYPNYLVVQNGT---------EYDFYSIGDLHGDKDAFIRILLNESIIDKVIRNNVLTVITGDVLDPTYDDIDIILFIKNYNESGKSLNSKIILLLGNHEVNNL---------------CLK---FK-TPQSNIENY---RNDMFRKGETIYNYLIDPFVVNVNNIIFSHAGVLPFYSYGIDFINEEGKREIINNC-------EYGPTLNRYYSYVTICSSLYKSLGLLK-----SSRMVIGHTVQNKQVNSFCQDKLLLADTGISRWGVISYIQYFNDG---------EYDFYSIGDLHGDKDAFIRILLNESIIDKVIRNNVLTVITGDVLDPTYDDIDIILFIKNYNESGKSLNSKIILLLGNHEVNNL---------------CLK---FK-TPQSNIENY---RNDMFRKGGTIYNYLIDPFVVNVNNIIFSHAGVLPFYSYGIDFINEEGKKEIINNC-------EYGPTLNRYYSYVTVCSSLYKSLGLLK-----SNRMVIGHTVQNKQVNSFCQDKLLLADTGISKWGVISYIQYFNDG---------EYDFYSIGDLHGDKDAFIRILLNESIIDNVIRNNVLTVITGDVLDPTYDDIDIILFIKHYNESGKSLNSKIILLLGNHEVSNL---------------CLK---FK-NPQGNIEDY---RNDMFRKGQEIYNYLIDPFVVNVNNITFSHAGVLPFYSYGIDFINEEGKKELINNC-------EYGPTLNRYYSYVTVCSSLYKSLGLLK-----SNRMVIGHTVQNKQVNSYCQDKLLLADTGISKWGVISYIQHFNDG---------EHDLFSIGDLHGDMDAFLKILLNEKMIDNVIRENVLIVITGDVLDPSYDDINILFFIEEYNEKGKALNSKILMVLGNHEVKNM---------------CLE---FN-KVKKNVEKY---RNDMFPKNEVIYNILVNPFVLRVNEMVFSHAGVLPFYAYGIDYINKEGKNEIENNC-------DYGPTLNRYFSFVNVCSTLNKSLNLLS-----SRRMIVGHTVQNKKINSFCDDKLLLTDTGISKWGVVSYVQYFKDGKKINSFCDDRNGLRIVGDVHGDLDAFRHA----------VATDRFVIQLGDLVDYGPDSAGVLRLMLQVMHE-----KRGLFLIGNHDRKLGRAL------------MGK---RLRSTPHLEDTLAQ-LYRPENTDLHALLPVLEPAWMVMGQTVFVHGAFDPRM---LGRVTYLLSRALFGETDGPERTLN----WVN--------------------TIPAGYTIYCGHDQRNGCPLA--GGQAIFVDTGAGKGGHLAWLDLPPPF---------GRKLRVVGDVHGDLHAFRHA----------AATDRFVIQLGDLIDYGPDSAGTFRLMQQLMDE-----RRGLFILGNHDRKLARAL------------QGR---KMRRDPPLMETLAQ-FMAEENADHQRALADLAPPWVVIGQSVFVHGGFHIRM---LGTVTPLLSRALFGETDGPERRLN----WVD--------------------HIPAGYTVYCGHDRRDGRPWV--GGRAIFTDTGAGKGGHLAWIDLPPLL---------GRPIRVVGDVHGDLRAFEHA----------VATDRFVIQLGDLVDHGPDSAGTFRLMQRLLDD-----GRGLFILGNHDRKLARAL------------AGR---KMRQDAPLIQTMRQ-FQAPENEDRTRAWQDIAPPWIVLGRRIFVHGGFHSRM---LGTVTPLLSRALFGETDGPERRLN----WID--------------------HIPPGYTVYCGHDRRDGRPWI--GGTSVFTDTGAGKGGHLAWIDLPDDA---------EHGIRVVGDVHGDFNAFRHA----------TATDRFVIQLGDLVDHGPDSAGVMELMLELLEQ-----QRGLFILGNHDRKLGRAL------------EGR---RLRRDPPLEETLRQ-ISLPEYEGPERAYRAIDPTWLRIGRSLFVHGGFHTAM---LGEMSAPLSRALFGETDGPERRLT----WIN--------------------RIPEGMTVYVGHDRRDGRPWR--GGTAVFTDLGAGKGGHLAWIDLNEP----------GAKLRVVGDVHGDSTAFAAA----------CATERFIVQLGDLVDDGPDTPGALRLMFGRLDA-----GRGLFLLGNHDYKLARAL------------RGD---SVQVGEALAATI-----ASLDPAAARAVEEIGPAWLVAGRVVFVHGGFDPAM---ADKRDRLLARALYGQTMGPERVLD----WVH--------------------RIPEGVTVYCGHDQRNGQPLT--GGRAIMMDTGAGKGGHLSWLDIDLP----------GAKLRVVGDVHGDSTAFAAA----------CATERFIVQLGDLVDDGPDTPGALRLMFGRIDA-----GRGLFLLGNHDYKLARAL------------RGD---SVQVGEALAATI-----ASLDPAAARAVEEIGPAWLVAGRVVFVHGGFDPAM---ADKRDRLLARALYGQTMGPERVLD----WVH--------------------RIPEGVTVYCGHDQRNGQPLT--GGRAIMMDTGAGKGGHLSWLDIDLP-----------MATYVFSDIHGHVEPLKRALERIN-----PTESDVFYCLGDMIDRGPSSLDTIKVIRAL--------PNCTVLMGNHEQLALQALANIEAQFMWQINGGDATLAELKTLSEEE-------------YCELIAWLQPLYVQGKDFVLVHAGVKSNG---VPVPTASLEQYLNKQS-------ENDLLWIREDFWQH------------RTSDASYPIVICGHTPT--WVQS--DDDKWGIDTGTTGGGQVTILRLDDLQ----------MRVLAIGDIHSGLKALEQVLAKAK-----VTTEDKLIFLGDYVDGWSQATETINFLIDLQKT-----HNCVFIRGNHDEFCRSWLTERKDNPMWYEHGGEATVNSYAKLDKQT-------------KELHIDFFTDYYLDEDKRLFLHAGFTNLK--------------------GDFEYFSKTFYWDR--------TLWELVLSLDPQRLTHYSEIYIGHTPV--------AANVWNVDTGAAFKGPLSIIDIATKQ----------MRTLVVGDIHSGLKALDQVLQRAE-----VTTNDKLVFLGDYVDGWSEAAETVDFLIELDKT-----HNCVFLRGNHDELCSDWLVKREDNPMWLQHGGAASAESYKKASQST-------------IDRHINFFNNYHLDAENRLYLHAGFTNVK--------------------GEHEYFQKTFYWDR--------TLWELALSLNPKRLLHYKEIYIGHTPV--------GANVWNIDTGAAFKGPLSIVDVDTKD----------MRKLVIGDIHGGLKALRQLLDRVA-----PAQEDFFVFLGDYVDGWSEAAETVDYLIGFARE-----HRCLFLKGNHDELCEEWLNGQAERELWLRHGGAATKKSYQGVGAAT-------------RGQHAKFFRAYHLDSENRLFLHAGFTNQR--------------------GEHEYFEKNFYWDR--------TLWETALSLDPARLRHYREIYIGHTPV--------AANVWNVDTGAAFRGPLSAIDAGNKE----------MRTLVFGDIHGGLRALEQLIEKVG-----INPTDKLIFLGDYVDGWSESAQTVEYLIQLSKK-----YQCVFIQGNHDLWCGRWLNLGVSNPVWEEHGGKATIQSYIQSGLLA-------------SAEHKTFYQEYHNGEDNRLYIHAGFTSMH--------------------GEKEENRLDFCFDR--------TLWEMALTMDPKRLVHYHEIFIGHTPT--------GCNVWNIDTGAGFSGKLTCMDVATKE---------MARTFVIGDIHGALKALEQVIGKIK-----PKAADTLIFLGDYVDGWSQSAQVIDYLMQLEKR-----YKCIFIKGNHDAWCESWLMGSLPDPTWIFNGGQATVESYAGLSPEQ-------------KDVHIAFYNDYVIDTENRLFIHAGFTSMH--------------------GAMERYEASTRWDR--------TLWEMACTMDPKRLLLYHEIYIGHTPT--------GCNVWNVDTGAAFYGKLTAMDIATKK----------MRTLAIGDIHGCLSAFNLLLEVID-----PRPEDVIVTLGDYVDKGHQSKGVIDKLISLHKR-----GQLVALKGNHELMMLEARQSLEKEFDWLNNDGKSTIDSYAKLGLPARL---------EDPDAHWHFIEVDWWERDNHFFVHANIDPY--LP------------------FEEQPEDKLFWEKFIN---------------PKPHYSNKIMVCGHTSQRGEPVN--IGYAICIDTWACGDGWLTGLDIETGQ----------MRTLAISDIHGCSIALETLLETVH-----LTPKDTLITLGDYIDKGPDSKGVLDKLINLYKN-----YRLIPLKGNHEIKMLQARQSDPDECFWLEFGGRETLNSYSKLGRKKTL---------ANPEEHWNFIQVDYWQTDNHIFVHANLDPN--LS------------------LKRQSEYDLFWKKFNY---------------QAPHYSGKTMICGHTSQNGKPIN--LGHRICLDTWVCGDGWLTCLELESGK----------MRTLAVGDIHGCTTAFDQLLEAID-----LRPEDKLITLGDYVDKGPNSKGVLERLLFLYEN-----HQLIPLKGNHELMMLDAFQGKRKDNFWLLTEGKTTLESYPQTN-DSPL---------LNPDSHWDFLKLDWYETDNHIFVHANLDPH--LP------------------LHKQSNHNLFWQKLYP---------------HHGHYSGKIVVCGHTSQDGCPVN--MGHQICIDTWACGQGWLSCLDVDTGK----------MRTLAVGDIHGCATAFDKLLEAIH-----LRPQDRLITLGDYVDKGPNSKEVLERLLYLYEN-----HRLVPLKGNHELMMLDAFQGKKKDDFWVIAGGKTTLQSYPQIEEDNPL---------LNPDSHRDFIKLDWYETDNHIFVHANLDPH--LP------------------LHKQSNHDLFWQKLYP---------------RHGHYSGKIVVCGHTSQNGSPVN--MGHQICIDTWACGQGWLTCLDVDSGK----------MRTLAVGDIHGCAKAFDKLLETIH-----LRPEDKLITLGDYVDKGPDSKGVLERLLYLYEN-----HQLVPLKGNHELMMLEAYQNQNHENFWVTVGGKATLASYGDTDKKNPL---------ANPDAHWTFVQLDWYETDNHIFVHANLDPD--LP------------------VHKQSGHDLFWQKLYP---------------RQGHYSGKIVVCGHTSQDGCPVN--MGHQICIDTWACGKGWLTCFDVNTGE----------MRTLAIGDIHGCSKALDHLLEIVN-----PKPQDTLITLGDYVNKGKDSKGVIDRLISLHKQ-----GNLIPLKGNHEIIMLQARHNPLKQRLWLEKGGKATLKSYSE----GHL---------IKPESHWDFLGINSYETANHLFVHASLDPY--LP------------------LARQPEYKLFWEKFQY---------------PAAHSSGKTMICGHTSQSGKPVN--LGHAICIDTWAYGQGWLSCLDVETGK---------EGRRIFIGDVHGHYDGLMRLLETIA-----PGQGDQIFFLGDLIDRGPASSQVVEFVKN---------SAYPCILGNHELMMLSAFEHTLHLLSWLSSGGRETIAGYTSRDL---------------FLEHMEWMQPYFLDLGDIWLVHAGVEPT--LP------------------LAEQTTEEFCWIRSNFHRS------------DRPFFADKTIVTGHTIT--------GSGWMDIDTGAYHPGWLTGLDWTAQT---------GQRRICIGDVHGHYDTLMALLELVA-----PGTEDAVYFLGDLIDRGPKSADIIEFVRR---------SSYQSLLGNHEMMMLEAIVQQETFIAWYHSGGANTLQSY-NHRI---------------PAEHLQWLRPTHLDLGDVWLVHAGLSPH--LP------------------IEQQGAEQFCWVRSEFHSM------------TQPYFANKLIIVGHTIT--------GPGWLDIDTGVYHTGWLTAFDIDQRQ---------SERRIVIGDVHGHYDTLNLLLEAIA-----PNQDDQVYFLGDLIDRGPQSSQVVELVMK---------HRYHCLLGNHEYMLLETVINSHQLQGWLYGGGYSTLVSY-DHHI---------------PQEHINWMKPTYLDLGDVWLVHGGIDPN--IP------------------LQEQTAQQFCWVRDDFHGM------------KKPYFEDKLIIIGHTIT--------GAGWLDIDTGAYHPGWLSALDLSTET---------THRRIVIGDVHGHYDTLIALLDAIA-----PASDDPIYFLGDLVDRGPESAKVVDFVRE---------NKYRCLLGNHEQMLLDVLISSEMFQSWLHSGGYSTLLSY-KHNI---------------PQEHLDWLKPHYLDLGDVWLVHAGVDPK--LS------------------LEDQTEEQFCWIRDQFHST------------TKPYFPDKLIIVGHTIT--------GVGWLDIDTGAYHPGWLTGLELTNKI---------SQRRIVIGDVHGHYEGLITLLEAIA-----PGGDDQVYFLGDLIDRGPHSSYVIDLVRD---------NNYLCLLGNHEQMLLNILISVATTQAWLHSGGHATIASYPDQSI---------------PKEHLEWLRPTYIDLGDVWLTHAGLDPN--LP------------------LSEQTAEQFCWIREDFHSI------------PQPYFPDKLVIIGHTIT--------GQGWLDIDTGAYHPGWLTGLDITNNL---------EPRRIIIGDVHGSFQTLLRLLNRVA-----PDSEDEVYFLGDLIDRGQQSLEVVDFVIK---------NNYQCLLGNHEYMLLKALVSEKWFNGWIESGGAATLLSY-NNNI---------------PAEHINWFQPAYLDLGDIWLVHAGVQPE--YP------------------LEQQTNEQFCWIRNEFHAM------------TQPYFKDKLIITGHTLT--------GSGWLDIETGVYHPGWLTALDWTNQL---------------MSDIHGCVDEFERALEQVLPHL--AEPGSELLLLGDYVHGGPASFAVIDRIMELQSRWP---DKVVALRGNHEQMMLEPG------------MGD------------------DERSHAHSEREYRAWLRPLYHVEGHVIFVHAGIDERA----------------------------GDLWRWGTDETT------------IGRFEDGWAIVAGHVST--------GEAHYYIDGDVLVSGRIPILLVDTAE----------MLIYAMSDIHGEKEAFEDALSVVDF----SRPDTVLVLCGDYFDSRHEHPEFLTYMREFQESHE---GQVVALMGNHEAWLL---------------EHD---TPASDPVFLDDMEEAKEEPLLRD-EKTRRWLSPLYYETDSQIFVHAGIDEDA----------------------------GEYWKLGVEDWY------------TYGTAFEKDIVAGHVGT--------GESHFFIDGTTEESKFVPVLKYDTET----------MKTYAMGDIHGCAAAFCEQLSELGFFD--SRCEDVLVLLGDYVDRGPNSLGVIREAMRLERDCP---GRVVALLGNHEDDLLRWLTPIERLRMWRAASGGATLRSFLGPAAYAELEDARACARIRCHADEVRWLCWLFHETERQVFVHAGIDESL----------------------------GVSWGT-SARDT------------IRFGTFPKDVIAGHTPT--------GASHFYMDGATFLSGRIPVLVYDSRD----------MRRYAISDIHGCIEPLQAQFEELGFFD--TDCADELVLLGDYVDRGPDSLGVLHAVMALEQRAA---GRVTVLRGNHDEMFLEWLDPEYRFRSFRQMPNLATMRSFLTDEQLRQLDHGTACHAIRNYPEVISWMQRDYHETERQIFVHAGIDESA----------------------------GREWALGTPRET------------TSNAPFYKDVICGHTPT--------GPSHIYIDGMTTASGVLPLLVWNSET---------ALRVALLTDVEGNWQYVRNVVRQSSCLK--LRDDCMLVFGGDAGDKGDQTLQCYEQLVSLKKRYP---DRVVLLVGNRDVNKMRFTNRLKWMLEHTMGQGDFERRRDVTDEEVVES---YMDSVKEGGVLYEYLLHSLAFVAHQTLWVHGGIINGD-PDVDELNRQVQEWI-----------E-HPTWNEKYVLPDVPLEISSLLSESG-----IRRVVIGHTPH--------GEEVIMCDTSYSDARAASELVVQPSG---------SRRVALLTDVEGNWQYVRNVVRQSSCLQ--LRDDCMLVFGGDAGDKGDHTLKCYEQLVHLKKKHP---DRVVLLVGNRDVNKMRLTNRLIWMLEHTMGQGDFERRREVTDDDIAKS---YLDSVEEGGVLREYLLHSLAFVAHQTLFVHGGIIDGD-PDVDKLNSQVQEWI-----------D-HPTWSEKYVLPDVPEEIASLLSESG-----IRRVIIGHTPH--------GEDVVMCDTSYSDACAASEVVVGPSG---------SLRVALLTDVEGNWDYVRNVARQSSCLQ--LKDDCLLVFGGDAGDKGDHTLKCYEQLVRLKKRHP---ERVVLLVGNRDVNKMRLTNRLKWMLEHTMGQGDFERRREVTDDAVVKS---YMDSVEEGGVLRDYLLHSLAFVTHQTLFVHGGIINGD-PDVDKLNSQVREWI-----------E-HPTWNEKYVLPDVPEEIASLLSESG-----IRRVIIGHTPH--------GEDVIMCDTSYSDANAASELVVEPSG---------GLRVALLTDVEGNWEYVRNVVRQSACLK--LRDGCMLVFGGDAGDKGEHTLKCYEQLVDLKKRHP---DRVVLLVGNRDVNKMRLTNRLKWMLEHTMGQGDFERRREVSEEDVVKS---YVNSVEDGGVLREFLLHSLAFITHQTLFVHGGIINGD-PDVDKLNGQVQEWI-----------E-RPTWSIKYVLPDLPEEAASLLSESG-----IRRVIIGHTPH--------GEGVIMCDTSYSDASAASELTVEPSG---------SRHICFLTDVEGNWNYVRNFVRQSTCLR--LNDDCFLVFGGDAGDKGGETLKCYEQLVRLKKKHP---ERVVLLAGNRDVNKMRFTNRLKWILEHTMGQGDFERRRTISDDAVLQS---FMESVQEGGVLREYLELSLAFVAYNTLFVHGGLISGA-PDVDKLNREVRAWI-----------D-RPLWTPKYVLPGLPSDVVQRLSESG-----INRLIVGHTPH--------GAEVVMCDTSYSDMRAASEVVLDPNG---------GRPIGYVTDVEGNAEYFCRYVEESTVVC--EADGAVFVYGGDVCDKGNGDLRVIACLLAFKEAFP---ERVFLLVGNRDVNKLRFSARLRWMLDCTMGEGAFDRRRSITDAQVYAS---YVGAAAKGGVLHKYLLQQIAALVDGTLFVHGAVNDAN-LAVAALNEQMAQW------------DASPQWEDDYGP--PSARVLAYLAASG-----VTRVITGHTPH--------GITFVIADTSYSDMSAITAIAVSSGG---------

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GDxHG GDxVDRG GNHE HGG MVVGHT IDVG Motif 1 Motif 2

Supplemental Figure S1: Alignment of the phosphatase domain of SLP protein phosphatases from both Prokaryotes and Eukaryotes. Candidate SLP phosphatase sequences identified as detailed in Materials and Methods were aligned using MAFFT. The alignment was visualized in GeneDoc and manually edited to remove the extreme N- and C- terminal regions outside the protein phosphatase domain, plus poorly aligned regions, prior to phylogenetic tree inference. Two conserved bacterial-like phosphatase motifs (orange) were identified in addition to the known canonical PPP-family protein phosphatase motifs (blue). Of the two bacterial-like PPP-phosphatase motifs, Motif 1 represents a novel region of conservation. Motif 2 was previously reported (Andreeva and Kutuzov, 2004). The gene identifiers of each sequence used here are located in Supplemental Table S1.

Page 2: Supplemental Figure S1 - Plant physiology · 2013-10-09 · Supplemental Figure S1 . Mglo SLP : Um SLP : PgraSLP : MlarpSLP : RgluSLP : BdenSL P: TgSLP : CparSL P: LbSL P: CneoS LP

Supplemental Figure S2

AlRLPHc :AlRLPHa :AtRLPHb :CarRLPHa :ThalRLPH :BraRLPH :AtRLPHa :CarRLPHb :AlRLPHb :CpaRLPH :CcRLPHa :CcRLPHb :CsRLPH :LuRLPH :MeRLPH :RcRLPH :VvRLPH :PperRLPH :PtRLPHa :PtRLPHc :PtRLPHb :CsatRLPHa :MdpRLPHa :GmRLPHa :PvulRLPH :GmRLPHb :GrRLPHa :GrRLPHb :AcRLPHa :AcRLPHb :MgRLPH :EgRLPH :BdRLPH :PvRLPH :SiRLPH :SbRLPH :ZmRLPH :OsRLPH :CsatRLPHb :PpaRLPH :SmRLPH :MdpRLPHb :MpRLPH :MpRLPHb :SrRLPH :BnRLPH :NgRLPH :F0SP41_PLA :D5SSG4_PLA :E8R2G2_ISO :GammataRLF :B0C4K2_ACA :B2J0C0_NOS :Q8YP31_NOS :D7E399_NOS :Q31LV8_SYN :Q5N017_SYN :C7QL34_CYA :B1WQZ5_CYA :B1X333_CYA :B0JSQ6_MIC :E0UA25_CYA :A8ZSZ1_DES :Q3A7H2_PEL :A7HLU4_FER :H9UCV4_FER :C5CDU8_KOS :D0MK25_RHO :D5H4I3_SAL :Q2S6K7_SAL :B8DK70_DES :E1YER6_9DE :I2Q722_9DE :G7Q752_9DE :E1K2K4_DES :H2J819_MAR :A9BIC6_PET :E3I2B3_RHO :G8API0_AZO :D3NZT3_AZO :G7ZAB6_AZO :H5YEZ7_9BR :E8L7W5_9RH :F2IW59_POL :E0TGJ0_PAR :Q11UR6_CYT :B7IWU6_BAC :B7HV78_BAC :C6GXU9_STR :E8UQ78_STR :D3QFL2_STA :B9DJA7_STA :Q3M5P0_ANA :Q8YZT4_NOS :F4B184_KRO :E4NEL1_KIT :F8JTJ0_STR :G8WZV1_STR :F2RD99_STR :E4N448_KIT :

* 20 * 40 * 60 * 80 * 100 * 120 * 140 * 160 * 180 * 200 * 220 *RTVICVGDIHGYISKLNNLWLNPQSAIDPSEFSSALVIFLGDYCDRGPETGKVIDFLISLPEKHPDQTHVFLAGNHDFAFSGFLG----EGWYRGSVKGMAYKGSIYDLESVKLFVGLPLDDYNNV--NH----------------------------LKAITAGL----KALKLLGVEWGVVEKEAAGKLAVAETHH-TLRIT-------------------------------RTVLCVGDIHGYISKLNNLWLNLQSAIDPSEFSSALVIFLGDYCDRGPETGKVIDFLISLPEKHPDQTHVFLAGNHDFAFSGFLG----EGWYRGSVKGMAYKGSIYDAGSTFESYGVPHGLMKAVPESHKKFLTNMVWVHEEDDVCIDTEEGLKHCKLIAVHAGLNNVEEQLKLLRAK--KIQHLSGRKTVVVSGHH-KLHIRLIIDEGGGFPPVAAIVLPSKKIIRDTDNLSSRTVICVGDIHGYISKLNNLWLNLQSAIDPSDFSSALVIFLGDYCDRGPETRKVIDFLISLPEKHPDQTHVFLAGNHDFAFSGFLG----EGWYTGSVKGMAYKGSIYDAGSTFESYGVPHGLMKAVPESHKKFLTNMVWVHEEDDVCIETEEGLKHCKLIAVHAGLNNVEEQLKLLRAK--KIQHLSGRKTVVVSGHH-KLHIRLIIDEGGGFPPVAAIVLPSKKIIRDTDNLSSRTVICVGDIHGYISKLSNLWLNLQSAVDPSDFNTALVIFLGDYCDRGPETRKVIDFLISLPEKHPDQTHVFLAGNHDFAFSGFLG----EGWYRGSVKGMPYKGSIYDAGSTFESYGVPHGLMKAVPESHKNFLTNMVWVHEEDDVCIETEDGLKHCKLIAVHAGLDNVEEQLKLLRAK--KVQHLSGRKTVVVSGHH-KLHIRLIIDEGGGYPPVAAIVLPSKKIIRDTDNLSSRTVICVGDIHGYISKLNNLWSNLQSSLNPSDFSSALVIFLGDYCDRGPETRKVIDFLISLPEKHPDQTHVFLAGNHDFAFAGFLG----EGWYRGSVKGMAYKGSIYDAGSTFESYGVPHGLMKAVPESHKKFLTNMVWVHEEEDVCIETEEGLKHCKLIAVHAGLNGIDEQLKLLRVK--KIQYLSGRKTIVISGHH-KLHIRLIIDEGGGYPPIAAIVLPSQKIIRDTDNVSSRTVICVGDIHGYITKLTNLWLNLQSALDPSQFTSALVIFLGDYCDRGPETRKVIDFLISLPEKHPEQTHVFLAGNHDFAFAAFLG----EGWYKGSVKGMAYKGSIYDAGTTFESYGVPHGLMKAVPESHKKFLTNMVWVHEEDDVCVETEEGVKRCKLIAVHAGLDSVEEQLKLLRAK--KVPYLSGRRTVLVSGHH-KLHMRLIIDEGGGYPPVAAIVLPSKMIIRDTDNVSSRTVICVGDIHGNISKLNKLWLNLQSDIQNSDFSSALVIFLGDYCDRGPETRKVIDFLISLPEKHPDQTHVFLAGNHDFAFAGFLG----EGWYKGSAYGVLYNGSIYDAASTFESYGVPHGLIKAVPESHKKFLTNMVWVHKEDDVCIETEEGLTHCKLIAVHAGLNNVEEQLKLLRDK--RIQPLTGRKTIVVSGHH-KLHIRLIIDEGGGYTPLAAIVLPSKKIIRDTDNFSNRTVICVGDIHGNISMLSKLWLNLQSALK-SDFSSALVIFLGDYCDRGPETRKVIDFLISLPEKHPNQTHVFLAGNHDFAFAGFLG----EGWYKGSAYGVVYNGSIYDAASTFESYGVPHGLMYAVPESHKNFLTNMVWVHEEDDVCIETEEGLKHCKLIAVHAGLNNVEEQLELLRAK--RIQPLVGRKTIVVSGHH-KLYIRLIIDEGGGYAPLAAIALPSKKIIRDTDDISNRTVICVGDIHGNISLLNKLWLNLQSDIEQSDFNSALVIFLGDYCDRGPETKKVIDFLISLPEKHPEQTPCLSCRKPRLCFCWVLG----EGWYKGSAYGVLYNGSIYDAASTFESYGVPHGLINAVSESHKKFLTNMVWVHEEEDVCIETEKGLKHCKLIAVHAGLNNVEEQLKLLRAK--RIQHLTGRKTLIVSGHH-KLHIRLIIDEGGGYAPLAAIVLPSKKIIRDTDNFSNRTVCCIGDIHGYFTKLKNLWSNLESIIDPPDFQSALVIFLGDYCDRGPDTRRVIDFLLSLPARYPNQTHVYLSGNHDLAFAAFVG----EGWYKGTVKGTDYKGSIYDAAPTFESYNVPHGLVKAVPDDHKKFLADMVWVHEEDDVCIETDEGIKHCRLIAVHGGLVKVEEQLEFLRAR--KVEALSGRKTIVVSGHH-ELHIRLIIDEGGGLEPVAAIVLPSMKVIRDTDNIAKRRVCCIGDVHGYISKLQNLWKNLETHIGPSDFNSAIIIFLGDYCDRGPNTREVIDFLISLPTKYPNQKHVFLSGNHDLGFAAFVG----EGWFKGAAKGTEYKGSIYDAAPTFESYGVAHGLVKAVPDHHKKFLADMLWVHEEDEVCVETNDGIKHCKLIAVHAGLKKVEEQLELLKAK--KVEALSGRKTIVVSGHH-KLHIRLIIDENGGLEPVAAIVLPSMKIVRDINNLV-RRVCCIGDVHGYISKLQNLWKNLETHIGPSDFNSAIIIFLGDYCDRGPNTREVIDFLISLPTKYPNQKHVFLSGNHDLGFAAFVG----EGWFKGAAKGTEYKGSIYDAAPTFESYGVAHGLVKAVPDHHKKFLADMLWVHEEDEVCVETNDGIKHCKLIAVHAGLKKVGEQLELLKAK--KVEALSGRK--------------VII----------------------------RRVCCIGDVHGYISKLQNLWKNLETHIGPSDFNSAIIIFLGDYCDRGPNTREVIDFLISLPTKYPNQKHVFLSGNHDLGFAAFVG----EGWFKGAAKGTEYKGSIYDAAPTFESYGVAHGLVKAVPDHHKKFLADMLWVHEEDEVCVETNDGIKHCKLIAVHAGLKKVGEQLELLKAK--KVEALSGRK--------------VII----------------------------RTVICVGDIHGYITKLQNLWTNLEALID--DFPTALVIFLGDYCDRGPDTKKVIDFLITLPSRYPNQTHVFLAGNHDLAFSAFLG----EGWYEGVAKGTEYQGSIYDAAPTFESYGVPHGLMKAVPESHREFLANMVWVHEEEAVCVEKEGEIKHCKLIAVHAGLKDVQEQLKLLKAK--KIEALSGRKTVVVSGHH-KLHIRLIIDEGGGLAPVAALVLPSMKLVRDTDSLLSRVVICIGDIHGYLAKLQNLWSNLQSVINPEEFSSALVIFLGDYCDRGPDTKKVIDFLLNLPSAYPNQKHVFLSGNHDLAFAAFLG----EGWYKGATKGTEYKGSIYDAGPTFESYGVPHGLMKVVPDEHKRFLADLVWVHEEENVCIESEEGIKHCKLIAVHAGLKNVEEQLKFLKAK--KVEALSGRKTIVVSGHH-KLHIRLIIDEGGGLEPVAAIVLPSMKLVRDTDDLTKRVVICIGDIHGYFSKLQKLWSNLEAIVNPQDFNSALVIFLGDYCDRGPDTKKVLDFLIKLPSFYPNQKHVFLSGNHDLAFAAFLG----EGWYKGVAKGTEYKGSIYDAGPTFESYGVPHGLIKVVPDEHKKFLVDMVWIHEEEDVCIENEEGMKHCKLIAVHAGLKNVEEQLAFLKVK--KIEALSGRKTIVVSGHH-KLHIRLIIDEGGGLEPVAAILLPSMKLVRDTDNFNK-----------------------------------------------------------------------------------------------VTKGTEYQGSIYDARLTFESYGVPHGLVKAVPDEHKKFLADMVWVHEEDDVCIQTEEGIKHCKLIAVHAGLEAVDEQLKTLKAK--KVGPLSGRATIVVSGHH-KLHIRLIIDEGGGLEPVAAVVLPSMQVVRDTDKLAKRVVCCIGDTHGFYTKLQNLWSNLQTTIDPSDFNTALIIFLGDYCDRGPDTKKVLDFLISLPSKYPNQRHVFLSGNHDLAFAAFVG----EGWFKGAAKNTQYKGSIYDAEPTFASYGVPHGLVKAVPDEHKKFLADMVWVHEEDDVCVETEDGIKHCKLIAVHAGLKDVKQQLEFLRAR--RIEALSDRQTVVVSGHH-KLHIRLIIDEGGGKEPVAAVVLPTMKIVRNTDVLANRLVICIGDIHGHITKLQNLWSNLETQFDPQHFNAATIIFLGDYCDRGPDTKKVLDFLIDLPSRYPNQKHVFLSGNHDFAFAAFVG----EGWYKGTIKGTECKGSIYDAGPTFASYGVPHGLLKAVPDDHKKFLADTVWVHEEDDVCIEDEEGIRHCKLIAAHAGLKNVGEQLRFLKAK--KIEALSGRKTIVVSGHH-KLHIRLIIDESGGFEPLAAIALPSMKLVRDTDNLTKRLVICIGDIHGYITKLQNLWSNLETQFDPQHFNAATIIFLGDYCDRGPDTKKVLDFLIDLPSRYPNQKHVFLSGNHDFAFAAFVG----EGWYKGTSKGIEYKGSIYDAGPTFTSYGVPHGLLKAVPDDHKKFLADTVWVHEEDDVCIEDEEGIRHCKLIAAHAGLKNVGEQLRFLKAK-----------IIVVSGHH-KLHIRLIIDEGGGFEPVAAIALPSMKLVRDTDNLTKRLVICIGDIHGHITKLQNLWSNLETQFDPQHFNAATIIFLGDYCDRGPDTKKVLDFLIDLPSRYPNQKHVFLSGNHDFAFAAFVG----EGWYKGTIKGTECKGSIYDAGPTFASYGVPHGLLKAVPDDHKKFLADTVWVHEEDDVCIEDEEGIRHCKLIAAHAGLKNVGEQLRFLKAK--KIEALSGRK-------------LLIFLSETFYPPFSPAFFSGKGLGC-------RVVCCIGDVHGYITKLQNLWSNLESSIHPSDFNSALIIFLGDYCDRGSNTREVIDFLVNLPSKYPNQKHVFLAGNHDFAFAAFLG----EGWFRGLAKGTDYQGSIYDAGPTFESYGVPHGLVKAVPDEHKKFLSNMAWVHEEDDVCLDTEDGIKHYKLIAVHAGLKDVQEQLNSLKAK--KIECLSGRRTMVVSGHH-KLHIRLIIDEGGGLQPVAAVVLPPMKIVRDTDNMKQ---------------ISNPPSTHQISPPPSSFSSAITATA------AXDTKKVIDFLVSLPSRYPNQKHVFLTGNHDLAFAAFVG----EGWFKGXAKGTEYKGSIYDAGPTFESYGVPHGLVKAVPDEHKKFLADMVWVHEEDDVCIETADGIKHXRLIAVHAGLKDVKQQLAFLRAR--KIQALSGRKTVVVSGHH-KLNIRLIIDEGGGMAPVAAVVLPSVKIVRDTDALTNRAVICVGDIHGFITKLQSLWKNLEGSLDRSEFETATLIFLGDYCDRGPATRQVIDFLISLPSRYPRQKHVFLCGNHDLAFAAFLR----EGWFKGTVKGTEYQGSIYDAGPTFESYGVPHGLVKAVPDDHKKFLADLVWVHEEDDVFVNTDDGVKCCKLIAVHAGLKDVKEQLKLLKAR--KVEALSGRKAIVVSGHH-KLHVRLIIDEGGGYKPVAAIILPSMKIIRDTDELAKRVVICVGDIHGFVTKLKNLWSNLERSIDRSEFETATVIFLGDYCDRGPDTRHVIDFLVALPSRYPRQKHVFLSGNHDLAFAAFLH----EGWFNGTVKKTEYQGSIYDAGPTFESYGVPHGLVKAVPDEHKKFLADLVWVHEEDDVFINTEDGGKCCKLIAVHAGL-DVNEQLKLLKAR--KVEALSGRRTIIVSGHH-KLHTRLIIDEGGGFKPMAAIVLPSQKVIRDTDVLAKRLVICMGDIHGFITKLQILWSNLEASLDRSEFETATLIFLGDYCDRGPGTRHLIEFLVSLPSRY------LLGG---------------------TVKGTEYQGSIYDAGPTFESYGVLHALVKAVPDDHKKFLADLVWVHEEDDVFVNTDDGVKCCKLIAVHAGLKDLKEQLKLLKAR--KVEALSGRKQKHLIRHH-KLHVRLIIDEGGGYKPVAAIILPSMKIIRDTDVLAKRTVICVGDIHGYVTKLLNLWSNLQSQIDPDSFNTATVIFLGDYCDRGPDTRKVIDFLITLPKRYSNQKHVFLSGNHDFAFGGFVG----EGWYKGAAKGIDYKGSIYDAAPTFESYGVAHGLMKAVPEAHKKFLADMVWVHEEDDVCIETQEGVKHCKLIAVHAGLKNVREQLEFLKAK--KVTDLSGRKTILVSGHH-KLHIRLIIDEGGGLEPVAAIVLPSMKIVRDTDNFS-RTVICLGDIHGYLTKLLNLWSNLQSQIDPDSFNTATIIFLGDYCDRGPDTRKVIDFLISLPKRYPNQKHVFLSGNHEFAFARFIG----EGWYKGVAQGIDCKGSIFDAAPTFGSYGVSHGLMKVVPEDHKKFLADVVWVHEEDDVCIETQEGVKHCKLIAVHAGLKNVREQLEFLKAK--QVTGLSGRKTIVVSGHH-KLHIRLIIDEGGGLEPLAAIVLPSMKIVRDTDNLS-RVVCCIGDLHGYISKLQNLWSNLESEIDPVSFQSALIIFLGDYCDRGPDTHKVLDFLISLPSKYPNQNHVFICGNHDFAFSAFLR----EGWYKDHAKGTEYKGSIYDAGTTFESYGVLHGLVKAVPDEHKKFLANLVWVHEEDNVSIQTSEGKRNYKLIAVHAGLKGVEEQLKLLKGK--KVAALSGRATVVVSGHH-KLHIRLVIDQGGGLEPIAAIVLPSLKIIRDTDAKVARVVCCIGDLHGYISKLQNLWSNLESEIDPVSFQSALIIFLGDYCDRGPDTHKVLDFLISLPSKYPNQNHVFICGNHDFAFSAFLR----EGWYKDHAKGTEYKGSIYDAGTTFESYGVLHGLVKAVPDEHKKFLANLVWVHEEDNVSIQTSEGKRNYKLIAVHAGLKGVEEQLKLLKGK--KVAALSGRATVVVSGHH-KLHIRLVIDQGGGLEPIAAIVLPSLKIIRDTDAKVARLVICVGDIHGYITKLRNLWTNLETAVGPSDFRSALVVFLGDYCDRGPRTDEVIDFLISLPSKYPDQSHVFLCGNHDLAFAAFLG----EGWYKGHAKNTEYKGSIYDAGPTFEAYGVPHGLMKAVPEEHKKFLRDLVWVHEEDDVSIEMKEGLQKCKMIAVHAGLKGVEEQLNYLKNK--KVEPLSGRKTIVVSGHH-KVHVRLIIDRGGGLEPVAAIVLPSKKMVLDTDEFATRTVVCVGDVHGHFTKLRALWANLESSIPPHAFRAALVIFLGDYCDRGPDTRRVIDFFLSLPSAYPGQTHVFLAGNHDFAFAAFVG----EGWYRGEAKGTEYKGSIFDAAPTFESYGVAHGLIKAVPEEHKKFLANMVLVHEEDDVCITTPEGTKHCRLIAVHAGLKDVGEQLRSLKAK--KIEAIAGRKTIVVSGHH-KLHIRLIIDEGGGYPPVAAVVLPSLKIIRDTDILPTRTVICVGDVHGFISKLESLWANLQSALPADAFATALVIFLGDYCDRGPHTRRVLDFLLALPARHPAQRHVFLCGNHDLAFAAFVG----EGWFHGPKKGLPYKGSIYDAQPTFESYGVAHGLTKAVPEEHKRFLHDLVWIHEGENVPIDTDEGQIVCKLIAVHAGLIDLNEQLRVLRTR--KVQMLSGRQTVIVSGHH-KLHIRFIIDEGGGYEPIAAVVFPSKQLIRSTEGTAPRTVICVGDVHGHITKLESLWSNLQSALPAGAFATALVIFLGDYNDRGPHTRGVLDFLLALPRRHPAQRLVFLCGNHDLAFAAFVG----EGWFRGPKKGLPYRGSIYDAQPTFESYGVAHGLAMAMPEEHKRFLRDLVWIHEEENVPIDTDEGQIICNLIAVHAGLIDLNEQLRVLRTR--KVPMLSGRQTIVVSGHH-QLHIRFIIDEGGGYEPIAAIVFPSKALIRSTEGTTSRTVICVGDVHGYIAKLESLWSNLQSALPADAFATALVIFLGDYNDRGPHTREVLDFLLALPGRHPAQRHVFLCGNHDLAFAAFVG----EGWFRGPKKGLPYRGSIYDAQPTFESYGVAHGLAKAVPEDHKMFLHDLVWIHEEENVPIDTDEGQIICNLIAVHAGLIDLNEQLRVLRTR--KVPMLSGRQTIVVSGHH-QLHIRFIIDEGGGYEPIAAIVFPSKTLIRSTEGAASRTVICVGDVHGYVTKLESLWSNLEAALPADAFATALVIFLGDYNDRGPDTRRVLDFLLELPTRHPGQRHVFLCGNHDLAFAAFVG----EGWFRGPKKGLPYKGSIYDAQPTFESYGVAHGLAKAVPEEHKRFLHDLVWIHEEENVPIDTDEGQIICNLIAVHAGLIDLNEQLRVLRTR--KVQMLSGRQTIIVSGHH-KLHIRFIIDEGGGYAPIAAIVFPSKTLIRSSEAH--RTVICVGDVHGYITKLESLWSNLQAALPADAFATALVIFLGDYNDRGPHTRRVLDFLLALPTRYPAQRHVFLCGNHDLAFAAFVG----EGWFRGPKKGLPYKGSIYDAQPTFESYGVAHGLAKAVPEEHKRFLHDLVWIHEEENVPVDMDGGQIICNLIAVHAGLIDLNEQLRVLRTR--KVQMLSGRQTIIVSGHH-KLHIRFIIDEGGGYEPIAAIVFPSKTLIRSTEEAGTRVVICVGDVHGYISKLESLWANLQSALPPDAFATALVVFLGDYCDRGPSTREVIDFLLALPSRHPAQRHAFLCGNHDLAFAAFVG----EGWYRGPKRGSSYMGSIYDARPTFESYGVAHGLVKAVPEEHKKFLRELVWIHEEENVPIDTNEGQIICKLIAVHAGLIDLNEQFRILRTK--KVAMLSGRQTIVVSGHH-KLHIRFVIDEGGGYAPIAAIVFPSKELIRSTEGTSSGVLCCIGDIHGYFTKLQNLWRNLESAIGASDFASATVIFLGDYCDRGPNSREVIQFLVSLPFRYPDQKHVFLAGNHEFGLAGFLG----EGWYKG-AYGIEFMGSVYDAAPTFESYGVPHGLMNAVPDEHKKFLSNLVWVHEEDDVCLETKDGIKTYRLIAVHAGLKDIEEQLKFLKAK--KIMGLSGRKTILVSGHH-RLHMRFIIDEGGSAPPLAAIILPSIKIVRDTDLL--RMTICVGDIHGHLDRLKALWRNLELKLGSEVFASSTVIFLGDYNDRGPDTKGVLEFLVGLPERYPKQRHVFLCGNHDFAFAAFLG----EGWWSGTTRNEPYKGSIYDARPTFESYGVSHGLIAAVPDNHKEFLRNLAWVHEQEGEETEDPE-TSYTKLIAVHGGLNSLDNQMQMLRTK--RIEPLAGRKVLLVSGHH-KLHFRLIIDESGGFDPIAAMILPAREIVRDTDNFSERPTVCIGDVHGHLIRLRALWRNLEAGLGA-LFASATVIFLGDYCDRGPDTAGVLDFLVALPASYPSQKHVFLCGNHDFGMSAFLG----EGWWSGVKKNMEYRGSIFDSEPTFSSYGVEHGLLGAVPEDHKAFLRKLVWIYEQ-------DGSESCGKLVAVHAGLRPLEEQLRVLREK--RHENMLGRSILSLSGHH-SLHMRLIIDESGGQDPLAAVVLPGRQIVRDTDSIGHSSRIS--------GPISNPPSTHQISPPPSSFSSGITAFPPDIRIRSTSSSPITTTWPSPPSWASCSR---------------------KGGLREATKGTEYKRSIYNDGPTFESYGVPHGLVKAXPDKHKXFLSDMVWVHEEDNVCIETADRIKHCRLIXVHAGLKDVKQQLAFLKAK--KIEAIFG--VVVLIVTD-ETNYKLTIDEGGGMAPVAAVVLPSMKIVLDTDALTNRATVLVGDVHGHRAKLVSLFENLEREIGAERLSTSRVVFLGDLVDRGPETSGVLDFIASLPAVHPSMEVRILGGNHDLGMATFCS----PLWVDA------GTRNAFDSEATFASFGVDPGLLSSLPESHAVLLSSLEFVVELDDV--EDDMHPEVNKLIAVHAGLRPIPEQLEALRER--WIEALQGRTVLVASGHH-ILKTWLVVDECAGLDQLAAVVLPERAVVKSH---------------------------LKLELGTERFETSTVIFLGDLCDRGPETSGVFNFLSSLKDKHPRQDVRHLAGNHDFAFATFLG----PLWEDS------DGINAFDSHTTFTSYSAAPGLLKKVPVEHKKILESLEFVVEVEDA--EEHG----KKLVAVHAGLCPFDVQMTALRQR--WVEALQGRAVIIASGHH-ILEMRIIIDGCGGHRRLAAVILPERKVVRSSS----DMCLCIGDLHGRYLRLQQLWTNASVYFGP-WMAGVDVVFLGDLCDRGSDTRQVVDFLLWLQRTRPNTTHI-IAGNHDFGLSSFLR-------------------SVFEAAATFESYGCKFPLLAAMPAAHLSFFRDLPWLVDL---------RFSFGRVICLHAGLKDMDPQMQLARER--FLEVIAGRGVIEVSGHF-FLDVRCIVDEGGGRDALAALVLPSRHILRHNEHVQTKRVVCIGDLHGNIDKITNLWANLQDQLGKEGLKKATVIFLGDYCDRGPDTKGVISWLIDLKKKRDASGTYFLCGNHDFSMAAYLG----PGYTSG--------CSIYNADSTFSSYGVKWGFIAAVPEAHKLFLKSLDWVCDI-------EIGFGPGRLIACHAGLGSLKDQLEGLKKR--RYFSFSARDAYLVSGHH-YREVRIICDRSGGYALLEAVILPSQPLNFVNDVRENKYIVAIGDLHGHLSALKLLMLKLEEALGNDLHQKYHLVFLGDYVDRGPKIKETIEYLIQLEKSRKPGTTHFLMGNHDFAMAMFLGLFDDELWKGN---------FTYSSFNTFYSYCTKDGLLRRMPESHKQFFRNMPWMLYN-------------EKNIFVHGGFSSLKEQMLPLMRRVPRIKPISERNRRIVSGHMQRVKVRALVDVSGGLTELACVVLPSCKVITTQPPVAAGPIAVVGDLHGQVDKLGVVLDAIQDA---PQFDDRWVVFVGDFVDRGPDTKACLDMVLEFMDYHPK--TTAVAGNHDFAMCSSLG----GRWL-----------DHYDSQATFRSYGVEFGLAAAMPLQHKKFLASLPWVVEH-------------PYTIIVHAGMTPTDMQLKILRQRLNRPQWLCEKKKTVVSGHVWRVTYRILCDTTGGLENLSAVLLPELQVVDSGNSSFPGPVAVIGDVHGQLDLLNFILSQLQQL---PNYDELWIVLIGDLVDRGPDPAGVIQRIVELREAHRR--TTVVFGNHELAMLGALG----PRWV-----------QFYDSEPTFRSYGVEPGLARAIPPEHREFLTTMPWVVEH-------------PENIFVHAGLQPTEMQLRILHAKLVRPPWLCDKARRIISGHVPEVVIRILTDTTGGLRELSCVILPECRILQSRGGVDRYPILAIGDLHGQSEEFDRLLDRVDRL---AEWPDCAVVFLGDFVDRGPDSRKVIDRVLEILERPPG--GAAVMGNHDLALVHAARLRSPHYWLER-------YLSVYDAATTVRSYVGRTWLRAAMPETHRRFLAELPWVVEA-------------SGHLFLHCGLADALAQVEAMKRRWDRPDYWLGADKIQVTGHCQRPDARIRIDTSGGYGPLTACLLPTDPPHFISSWDDLYPVVAIGDLHGRVEWLDKLVAKLRRR---PEWPHAKLVFLGDLVDRHFEVRALVSRVLELIAEKPG--STCVAGNHDLALVRAAG---LVEWAQR-------YGRNYDHQWTFRSYLGRTPLKAAMPAEHRAFLAGLPWVAEA-------------EGHVFLHNGLCPAAVQLECLHRKWDRPEYWLGADKVQVSGHVHAPDARIRIDTSGGVTPLTACVLPNAEPVFVFSNE--LRRFVIGDIHGHYQGLLDLVSLLEIG------ESDQIYFLGDLIDRGPDSSKVVDFVREQ-----S--YTCLLGNHEQLMVAALANLSPQMWL-Q---------A--GGRETLQSYSSK-----QHLWEHLSWIKTLPNHLDL-------------GDYWLVHAGILPLERQTAQEFC-WIRREFHNMP-RMIITGHTMFSGVWLGIDTGAYHPWLTALELSSSTVYQINVHSNVPRRIVIGDVHGHYEGLMTLLEAIAPT------SDDQIYFLGDLIDRGPHSSQVVNFVKRH-----N--YPCLLGNHEQMLLNILTNERTQAWL-Y---------S--GGQATVASYHEA-----SIPDDHLDWFKSLPTYLDL-------------GDIWLTHAGVKLVTEQTADQLC-WIREEFHSIE-KLIIIGHTILPGVWLDIDTGAYHPWLTGLDVTNNLVYQVNIFKNYQRRIVIGDVHGHYEGLVTLLAAIAPG------GDDQVYFLGDLIDRGPHSSYVIDLVRDN-----N--YFCLLGNHEQMLLNILSGDISQAWL-H---------S--GGHATIASYPDQ-----SIPKEHLEWLRSLPTYIDL-------------GDVWLTHAGLLPLSEQTSEQFC-WIREDFHSIP-KLVIIGHTIFPGVWLDIDTGAYHPWLTALDITNNLIYQINIFTNCPRRIIIGDVHGYYQGLMNLFDKIAPS------SADQVYFLGDLIDRGPQSAQVVDFVKQN-----D--YCCLLGNHEQMLLNVFGNRSHQAWL-Y---------S--GGQATITSYQAA-----QIPQEHIDWFLTLPTFIDL-------------GDYWLTHAGVKSVSEQTAEELC-WIREEFHSME-KLIIVGHTILPGVWLDIDTGAYHPWLTGLDITNNLVYQVNVFNNSGRRLIIGDVHGHYRSLYRLLELADPD------TDDQVYCLGDLIDRGPDSAKVVALVRSQ-----G--YTSLMGNHEHLLSQVLAFPDL-HWF-Q---------A--GGQATLASFGSW-----EALEELRPWLQQLPLYLDL-------------GEIWLVHAGVLPLSRQDANEFC-WIRDQFLARS-KTILVGHTIMAGIWLGLDTGVYHPWLTALDWDNQRVFQVQAQSNEGRRLIIGDVHGHYRSLYRLLELADPD------TDDQVYCLGDLIDRGPDSAKVVALVRSQ-----G--YTSLMGNHEHLLSQVLAFPDL-HWF-Q---------A--GGQATLASFGSW-----EALEELRPWLQQLPLYLDL-------------GEIWLVHAGVLPLSRQDANEFC-WIRDQFLARS-KTILVGHTIMAGIWLGLDTGVYHPWLTALDWDNQRVFQVQAQSNEMRTLAISDIHGCSIALETLLETVHLT------PKDTLITLGDYIDKGPDSKGVLDKLINLYKNY-R--LIPLKGNHEIKMLQARQSDPDCFWL-E---------F--GGRETLNSYS----TLANVPEEHWNFIQNLCVYWQT-------------DNHIFVHANLLSLKRQSEYDLF-WKKFNYQAP--KTMICGHTSKPINRICLDTWVCGGWLTCLELESGKIWQANQRGQIMRTLAVGDIHGCATAFDKLLEAIHLR------PQDRLITLGDYVDKGPNSKEVLERLLYLYENH-R--LVPLKGNHELMMLDAFQGKKKDFWV-I---------A--GGKTTLQSYP----PLLNVPDSHRDFIKQHCLWYET-------------DNHIFVHANLLPLHKQSNHDLF-WQKLYPRHG--KIVVCGHTSSPVNQICIDTWACGQWLTCLDVDSGKIWQTNQQGEVMRTLAVGDIHGCTTAFDQLLEAIDLR------PEDKLITLGDYVDKGPNSKGVLERLLFLYENH-Q--LIPLKGNHELMMLDAFQGKRKNFWL-L---------T--EGKTTLESYP----PLLNVPDSHWDFLKQCCLWYET-------------DNHIFVHANLLPLHKQSNHNLF-WQKLYPHHG--KIVVCGHTSCPVNQICIDTWACGQWLSCLDVDTGKIWQTNQQGEVMRTLAIGDIHGCSKALDHLLEIVNPK------PQDTLITLGDYVNKGRDSKGVIDRLISLHKQG-N--LIPLKGNHEIIMLQARNNPLKRLWL-E---------K--GGKATLKSYS----HLIKIPESHWDFLGKVCISYET-------------ANHLFVHASLLPLARQPEYKLF-WEKFQYPAA--KTMICGHTSKPINAICIDTWAYGQWLSCLDVETGKLWQVNQRGNFMRTLAIGDIHGCLEAFNLLLDVVALR------PNDTIITLGDYINKGPQSKGVIDQLIALHERG-Q--LVALKGNHELMILEARKSLEKFEWL-K---------K--YGTSTLLSYS----TLEDIPPHHWDFLQNICLWWET-------------KEHFFVHANILPLDQQLEDKLF-WAKFVDPQP--KVMICGHTSLPLNAICLDTWVCGEWLTCLDIDSGQIWQTNQQGKVGKIFAVGDIHGCYKKLRVLMDRIPINY-----KEDTLVFLGDYIDRGDESFEVVAYLAELRKKHPG--IVFLKGNHEELFFNYLSGEDEVSFL-F---------N--GGEQTLKGYMSPD-GDISVPKEHLNFFNALQLYYET-------------DDYIFVHAGLVPLEQQKPEDLL-WIRKPFIESS-KIVIFGHTPEVVVKIGVDTGAVYGKLTCIELPARKFYEA------GRLLAIGDIHGCHRALRSLLARLSPN------RGDRMVFLGDYIDRGPDPRGVIDTLLAVRRRVMR--CTFLMGNHERMLLDVLEGRNLPLYL-A---------N--GGLVTLLAYMTE--GQLRLPASHRRFFNGLQRFHAT-------------GSHIFVHAGLCPLSQQTEEDLL-WIRDAFLASD-KTVVFGHTPKPLLRIGLDTGAVYGVLTACDLHTRRLWQAREPNRD-MLWAIGDIHGCLNALETLINEISPT------PNDKLVFLGDYIDRGPDSKGVVDFLIELSKRT-D--CIFLRGNHEQMLLDVIDNGDDYLWV-I---------N--GATATWRSYGNL--QNLLYNDEHLEFFRNTQYYFIE-------------DKYLFVHGGVIPIEKQDKRDLI-WIREEFISKK-YIVIFGHTPDVFIKIGIDTGCVYGKLTAYNLTLSKKVEVECLNG-MGLWAIGDIHGCLRALERVIERISPS------EHDKLIFLGDYIDRGPDAKGVVDFLLLLSKMT-Q--CVFLRGNHEQMLLDVIDNNDDFLWN-L---------N--GAQATIRSYGNL--IQLETNEEHMSFYRNTKYYHIE-------------GKYLFVHGGVVPIEKQEPRDLI-WIREEFILKR-FVVVFGHTPEVYFKIGIDTGCVYGKLTAIEVNQKVVIQEDCRNVR-MIYAIGDIHGCLESLKKLIEKINPS------RTDMLIFVGDYIDRGPNSKGVVDFLIKLSRSR-K--CIFIRGNHEQMLLDYLNGGKTKLWH-F---------N--GMEYTINSYG----GIDKIPEKHIRFFEKTILFHET-------------DEYVFVHAGVIPLNKQKDGDLL-WIRDEFIYAE-KVVIFGHTPEPLIKIGIDTGCVYGKLTALRLDDMCFFSVKSIF--MALIAIGDIHGCARTLDALLDRLAPT------RDDQLVFIGDYIDRGPDARGVIERLLRLREEI-S--CVFLRGNHEALMLNYLDRGEADLWF-I---------N--GGLTTLNSYRND---GIRIPEEHEAFIRETLLYYDT-------------PDFFFVHGGLLTIAEAHTDLFL-WEREHLNAPR-KPVVCGHTPEPINLIAIDTGCVYPRLTAVRLPERTFISIPRQDLIMGLIAVGDIHGCLESLNALLDRLNPS------SDDHLLFVGDYIDRGPDSRGVIDRLLDLRESI-S--CTFLRGNHEAMMIDYLDSGAFSLWR-M---------N--GGVSTLQSYLKGEGSEVHIPAAHAEFVRDTKLYHET-------------DDFLFVHAGLLTVEEPDEEVLL-WERGHLEASG-KTVVCGHTPDPISLILIDTGCVYHRLTAVHLPQREFIDVPYADG-MGLIAVGDIHGCLESLNALLDRLNPS------SDDHLLFVGDYIDRGPDSRGVIDRLLDLRESI-S--CTFLRGNHEAMMIDYLDSGAFSLWR-M---------N--GGVSTLQSYLKGEGSEVHIPAAHAEFVRDTKLYHET-------------DDFLFVHAGLLTVEEPDEEVLL-WERGHLEASG-KTVVCGHTPDPISLILIDTGCVYHRLTAVHLPQREFIDVPYADG-TRTFAIGDIHGHRDRLEALLRRLPLDR-----ERDTVVFLGDYVNRGPDSRGVIDLLLGLQRTCPG--AVFLRGNHEQILLDYADTGDALLPL-L---------RFLGVEATLRSYGVD--GLACLPPEHAAFLRGLAFAHET-------------ATHVFVHAGLPRSETQRLDSRR-LVRRDMAPHD-RTVVFGHSSTPLVRIGIDTGAGGGMLTALELPALRFHHA------GKIFAIGDIHGCYDKLISLMDRLPFDL-----HSDTLIFLGDYINRGSQSKEVIEYLLKLKQSSEN--IIFLKGNHEHALLEYAQTKDQYLRL-L---------RSMDVEPTLKSYSDA--DLGFLPPAHLDFLNGLLTYYKT-------------DDYLFIHAGVEDPDGCSLDRLL-SVRDTFLRYE-YTVVFGHTPMPLVMIGIDTGAVYGMLTAVLLPDLRFFHA------GKLIAIGDIHGQSDALRRLLDDLPYRP-----GRDRLIFLGDYINRGPDTRGVLEVLSALRRDDPG--AVFCLGNHEEALLRYAAGGDPDLRL-L---------RTLGIETTLESYGDL--GLSFLPEEHREFLLGLESFRRI-------------GPYVFVHAGLLPPEACPPDCLL-SVRGAFLTGP-LTVVFGHTTTPLVKIGLDTGAAWGALTALVLPDMVFLHAPGDRFLGKLIAIGDVHGQSDALRRLLDDLPYTP-----GRDRLIFLGDYINRGPDTRGVLEILATIRRDDPG--AVFCLGNHEEALLRYAAGGDPDLRL-L---------RTLGIETTLESYGDL--GLAFLPEAHREFLLGLESFRRI-------------GPYVFVHAGLLPPEACPPDCLL-SVRGAFLTGP-LTVVFGHTTTPLVKIGLDTGAAWGALTALVLPDMVFLHAPGERFLARLIAVGDIHGQADALRRLLDDLPYRP-----GTDRLIFLGDYINRGPDTRGVLDLLTDIARQDPG--AVFCLGNHEETLLRYADEGEPDLRL-L---------RGLGIETTLRCYGDP--GLSFLPPEHQAFLRALVPYARI-------------GDMLFVHAGLLPPEECPTDCML-SVRGAFLSGP-LTVVFGHTTTPLVKIGLDTGAAWGALTACILPDMELRHVFI-----MIWAISDIHGMYDNLIKVLNQIP--------ENDKIIFLGDYVDRGPGSRQVLDLLFKLKNR-----AVFLKGNHEDMMLDYFENTGKGAWF-R---------N--GAQATLDSFNND------IEEKYLDFIRNLKLYHGT-------------QKYLFVHGGIISLSDQAERDLL-WIRDDFYMSD-YIVIHGHTPYITGSIDIDTGCVYGKLSALGISNDNKYDIISI----MIWAISDIHGMYDTLISLLKRIQIK------DSDTMIFLGDYVDRGPDSKKVLDLLITLSKQRN---RIFLKGNHDDMMVDYCQKTHEGVWF-Y---------N--GALSTIKSFNNN------IGEEYINFLKDLPLYYEN-------------EKYLFVHAGVKSLSKQDKWDLL-WIRDEFLSMS-YTVIHGHTPYLTGSVDIDTGCVYGKLTAFGITEDNRHVVLQAV--MRVYAVGDIHGRLDLLEIMLDLVDADQHERGIRPALIVFLGDYVDRGPSSKEVVDAFIGELGEALS--PVFIKGNHEALLMSFLYDATPNFWL-K---------N--GGDAALLSYGLDPDFREALPASHLSFYCNLKPSFRI-------------GGYFFVHGGVVPLDQQREEDLL-WIRDPFLTSD-AVVVHGHTPEPQLRIGVDTYAFKSRLTAVGLEGTERWILSTAS--VRVYAVGDIHGRLDLLEQLLAQIDRDAASGADLVKYLVFLGDYVDRGPDSAMVIERLCREPLPGFG--AIHLRGNHEAAMMDFIEKPEAPDWL-E---------Y--GGRATLASYGVPAPFAAALPPHHRTFLAGLRSSVAI-------------GDYLFVHAGILPLHRQRDEDLL-WIRREFLTSH-KLVVHGHTIQPDIRIGIDTGAYASRLTALVLEGGERRFLCTI---MRVYAVGDIHGRLDLLDQMMGQIARDAAQAPNLLKYIVFLGDYVDRGPDSRLVIERLACGLPPVLG--AVFLRGNHEDTLLGFLSDLRVPGWL-T---------Y--GGDATLESYGIPAPLNSLLPAHHRAFLTGLRCHLTI-------------GDYHFVHAGVVPLDRQEDKDRL-WIRDAFLASR-KVIVHGHTIEPELRIGIDTGAYATRLTALVLEGAERRFLCTV---MRVYAVGDIHGRLDLLDQMLGQIAHDAGQAPNLLKYLVFLGDYVDRGPDSRLVIERLACGLPPVFG--AVFLRGNHEDTMLSFLSDLRIPGWL-T---------Y--GGDATLESYGIPAPLNGLLPPHHRAFLTGLRNHLTI-------------GDYHFVHAGIIPLDRQEDKDRL-WIRETFLASR-KIVVHGHTIEPELRIGIDTGAYATRLTALVLEGTERRFLCTV---VRIYAVGDLHGCADLLAGAFDLIDADLARSRPEQAIQVFLGDYIDRGPDAKRTIDLLIDRGQRHE---TVFVRGNHEALLLRLLDDPKMPNWI-K---------L--GGMTTLMSYGITISLAAAIPSAHTDFLANLVPFFSC-------------GDYFFVHAGVVPLDKQSEEDLM-WIREPFLSSD-KVVVHGHTPEPEIRINIDTGAYATLLTVLSIQDDKVEFHSSSRSRLRLYVIGDVHGRLDLLDDLSKQIAADLDDAP-ADVLTIFVGDYIDRGRESAGVIDRLNRGEFPTP---FHALRGNHEEILLKFLEDESVESWR-K---------F--GGLETLHSYGVDVSLLELMPETHRRFLEGTDLFASF-------------GDYLFVHAGVVPVHLQNADDLL-WIREEFLRFR-KVVVHGHTPAPDVRINVDTGAFATVLTALVLEGADRRFLQTRAP-TRVYAVGDIHGRFDLLWRLAGAIEADLAARPVARVVEVYLGDYVDRGPDSARVVDWLSRPAAGGRE--RICLMGNHEHALLSFLADPGLAQWR-Q---------F--GGGETLISYGIDLPLRAALPVSHLRFLRALPALHRI-------------GGYAFVHAGVVTLDAQVETDLL-WIRQEFLDYP-AVVVHGHTPTIDLRINIDTGAYMTRLTCAVLDADGVRFLQTTREGKILVAIGDIHGRLDLLDRLLPKISEHLDG---RAARLVFLGDYIDRGPDSAGVLDRLIGVRESFSD--CVFLKGNHEEALLDFLAAPEEASWL-G---------W--GGDATLLSYGLDTDFAAALPDDHFRFLLDLELFHRA-------------APYQFVHAGLLPFDRQIERDLL-WIRDRFFNAN-WVIVHGHTPAPDNRINVDTGAVWSQLTAVVLDGEDRRFLTS----KRTFVIADIHGCYKSLKALVENLQPT------HEDQFIFLGDYIDRGPDSKAVINYLIYIKEHYKN--CVFLRGNHEQMFLDAHQSIAAERWI-I---------N--GGEEVMISYGLK--NHDHVPYHVQDFISNTFYYFQD-------------ERFIFVHAGIAESPLKDYNSMM-WIRNAEITHT-RIVVHGHTPLDTIEICLDNGCVFKQRTGLGLHSNRLYVQNNIDF-KRILVISDIHGEIEKFEQLLKEAQYDA-----KQDQLILLGDYVDRGPNARAVIEKVKELKEE--G--ALILKGNHEDMMIKALTTNEENHWVKR---------N--GGDKTLYSYGFLEELQSSVLEEHIKFIQELDHYIET-------------EEYIFVHAGVKRVSESEPYTLM-WIRNEFHNG--KVVVFGHTETLHSIIGIDGGAVYGQLNCLELPSKKVYVIKN----KRILVISDIHGEIEKFEQLLEEAQYDA-----KKDQLILLGDYVDRGPNARAVIERVKELKED--G--ALVLKGNHEDMMIKALTTDEENHWVKR---------N--GGDKTLYSYGFVEELQSHVLEEHVKFIQELDHYIET-------------EKYIFVHAGVKRVSECEPYTLM-WIRNEFHNG--KVVVFGHTETLHGIIGIDGGAVYGQLNCLELPSKKVYVIKS----KEFFVIGDVHGKFELLLDILKKWNE-------KRQQLIFLGDLIDRGENSKACLELVWSLVREK-G--AICLTGNHERMFLAWLRDPIDDHYR-R---------N--GGDTTINSLLGRPLLEQY--EDLIDFVKSCPYHLET-------------EDYIFVHAGVLPDWRTSNHDKV-WLRTPFHEAE-KMIVFGHTPNLYQKMGIDGGAVYGVLHGIVLDGTGLVQDYIVGAVKEFFVIGDVHGKFELLLDILKKWNE-------KRQQLIFLGDLIDRGENSKACLELVWSLVREK-G--AICLTGNHERMFLAWLRDPIDDHYR-R---------N--GGDTTINSLLGRPLLEQY--EDLIDFVKSCPYHLET-------------EDYIFVHAGVLPDWRTSNHDKV-WLRTPFHEAE-KMIVFGHTPNLYQKMGIDGGAVYGVLHGIVLDGTGLVQDYIVGAVQRILVASDIHGHGDALIKLLSEAVYNA-----ETDQLVLLGDYVNNGPDSVGTLRLVQKLVNKG----AIALVGNHELRWLERQD---------------------------------------SEAQAWHKFLSGLPYIKVL-------------DSYIFVHAGIVPIDKQQCEHVT-AHHSVALNQH-KTIIHGHVPEIHIMIDIDTGAGHNYLTLVDLTNACSYSVNVSHKDGRLFVASDIHGHGETLRQLLETAEYSP-----GNDQLVLCGDYVNNGPDSEGTLELIQKLQKD--G--AVVLFGNHELRWLEEIA----TEFIMH---------H--KMKVTYQRIQKD-----WGKLKWRSLLESFDKYYMT-------------DDFLFIHAGFVPLEKQTAAEVT-GYDKTKDLQH-KYMVHGHVPEIKVSVNIDTGAGHGYLTLLDLTNSKQYCQRVVMKEMRTIVVGDIHGCYAELLQLLAKVEIA------EEDCLVSLGDIVDRGIDSVKVYDFLKNRPN------TIVLMGNHERKHLRQTLSYSQ--------------------------------QFGDSYDEFLEWISHLPYYHET-------------ESAIFVHAAVIPIEEQREEVLC-WSQ--------KPVIFGHRVHPLITYGIDTGACHGTLTAIILPSFEIVQVQAAKDYMRTIIVGDIHGCYEELLQLLTKAQIT------KEDCLISLGDIVDRGVDSVRVYDFLKNRPN------TIVLMGNHERKHLRQTLSYSQ--------------------------------QFGDRYPEFLEWVSHRPYYHET-------------DAAILVHAAVIPIGEQRPEVLC-WSQ--------KPIIFGHHVIPLIIYGIDTGACHGKLTGLILPSFEVVQVQAPQDYMRTLVFGDIHGGYRALVQVMKRANVT------RDDHLIFLGDYVDGWSESDAVIDELMRIKKEYKK--VTLIRGNHDDLVQQWLEGKTMPKWL-Q---------H--GGQSTIDCYEKR---SAQEIQWHIEFYKTFEDYLDD-------------ENRFFCHAGFGPEYEWHSTAFY-WDRDPLYPKRLEEIYIGHTPVPVNIWNLDTGAAFKSLTVMDVDTKEFWQSDALPSLGPLFVIGDVHGYLDELLAALHQLIDTEGHWSAGRSRIWFLGDFTDRGPDGIGVIDLVMQLAAEAAAAGCRALMGNHELLFLGASR----AAWRLN------------GGQQH---------DLERLQPHHISWLSRLPAMALE-------------DGHLLLHSDTLEYGETIADVNDAW--DAFFTKRFYRVVHGHSPGPYIAIAMDGGVTMDRLLVARLPLN-----------GPLYVVGDVHGYLDELKAALRELIDAEGHWSAGQSRLWFLGDFTDRGPDGVGVIDLVMQLSAEAAAAGAKALMGNHELLLIGAKR----AAWRLN------------GGQPT---------DMERLQDHHIAWMSRLDAIALE-------------DNHLLLHSDTLEYGSSIEEVNDAW--ELFFTKRFGRVVHGHSPGPHLALAMDGGVTMERLLVAQLPLRG----------GPLYVVGDVHGYLDELKAALRELIDAEGHWSAGQSRLWFLGDFTDRGPDGVGVIDLVMQLSAEAAAAGAKALMGNHELLLIGAKR----AAWRLN------------GGQPT---------DMERLQDHHIAWMSRLDAIALE-------------DNHLLLHSDTLEYGSSIEEVNDAW--ELFFTKRFGRVVHGHSPGPHLALAMDGGVTMERLLVAQLPLRG----------GPLYVVGDVHGYLDELVAALRALIDENGGWAAGNARLWFLGDFTDRGPDGIGVIDLVMRLSAEAAAAGCKALMGNHELLLIGAKR----AAWLLN------------GGQKH---------DMDRLQDVHLQWMSRLDAVVRE-------------DDHLLVHSDTLEYGQTIEDVNETW--DVFFTKRFHRIVHGHSPGPHVAIAMDGGVTMAKLLVVQLPLNG----------TPLYVAADIHGHRTEFRAVLRALADENGHWSGGRARLWLLGDHVDRGPDGIGVIEDVRRLAAQARDEGVGALLGNHEVQLLAAHR----GGWARF------------GGQEA---------DLRGLTPSHLEWLAALPAAALV-------------DGHLLVHSDTLELGTSVAAVNAAWL-EFSMSSRGSVLVHGHSTAALRVLAIDGGAYLGRILLTRL--------------

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GDxHG GDxVDRG GNHE HGG VVSGH IDEG Motif 1 Motif 2

Supplemental Figure S2: Alignment of the phosphatase domain of RLPH protein phosphatases from both Prokaryotes and Eukaryotes. Candidate RLPH phosphatase sequences identified as detailed in Materials and Methods were aligned using MAFFT. The alignment was visualized in GeneDoc and manually edited to remove the extreme N- and C- terminal regions outside the protein phosphatase domain, plus poorly aligned regions, prior to phylogenetic tree inference. Two conserved bacterial-like phosphatase motifs (orange) were identified in addition to the known canonical PPP-family protein phosphatase motifs (blue). Of the two bacterial-like PPP-phosphatase motifs, Motif 1 represents a novel region of conservation. Motif 2 was previously reported (Andreeva and Kutuzov, 2004). The gene identifiers of each sequence used here are located in Supplemental Table S1.

Page 3: Supplemental Figure S1 - Plant physiology · 2013-10-09 · Supplemental Figure S1 . Mglo SLP : Um SLP : PgraSLP : MlarpSLP : RgluSLP : BdenSL P: TgSLP : CparSL P: LbSL P: CneoS LP

PrpE_1 :PrpE_2 :PrpE_3 :PrpE_4 :PrpE_5 :PrpE_7 :PrpE_10 :PrpE_9 :PrpE_8 :PrpE_6 :Q0ALJ2_MARMM :AaALPH :EhALPHa :BnALPH :CmALPH :PtALPHa :TpALPHb :EsALPH :CpALPH :F8CMG1_MYXFH :Q1CWE7_MYXXD :H8MWN3_CORCM :Q097S7_STIAD :A9ER55_SORC5 :EhALPHb :EhALPHc :CocALPHa :AqALPH :BfALPHa :BfALPHb :SkALPHa :SkALPHb :LgALPH :CtALPH :GtALPHa :CgALPH :CocALPHb :PcALPH :PrALPH :PsALPH :PiALPH :PuALPH :IsALPH :AmALPH :RpALPH :SpALPH :CvALPHb :E3FDL0_STIAD :F8CB73_MYXFH :Q1DC62_MYXXD :LmALPHb :TbALPHb :TcALPHb :TbALPHa :TbALPHc :TcALPHa :A7HDV6_ANADF :B4UIJ2_ANASK :B8JET4_ANAD2 :Q2ILE6_ANADE :CrALPH :VcALPH :FcALPH :TpALPHa :PtALPHb :CvALPHa :SaALPH :E4NPT8_HALBP :Halosarcin :G0LN38_HALWC :J3A001_9EURY :Halogranum :D4GUB7_HALVD :E7QTB4_9EURY :Halorubrum :G0I0G4_HALHT :Halosimple :C7P488_HALMD :Natrialba :D2RRW5_HALTV :F8D2X2_HALXS :I7BUV9_NATSJ :Natronorub :Halovivax :LmALPHa :OdALPH :FgALPHb :FgALPHa :AnALPH :ApaH_1 :CsApaHb :HhApaH :RprApaH :SrApaH :BiApaH :SsApaHa :SsApaHb :RcApaHa :RcApaHb :AaeApaH :AgApaH :PotApaH :HvApaH :XtApaH :PscApaHa :HmApaH :AstApaH :OsApaHa :OsApaHb :PscApaHb :LsApaH :ApaH_9 :ApaH_3 :CarApaH :OvApaH :ApaH_5 :ApaH_6 :ApaH_8 :ApaH_10 :ApaH_4 :ApaH_7 :F9ZYF7_METMM :A0L5C1_MAGSM :ApaH_2 :Q7NN25_GLOVI :PA3087_1 :PA3087_5 :PA3087_2 :LsPA3087 :PA3087_9 :PA3087_8 :PA3087_7 :PA3087_3 :PA3087_10 :PA3087_6 :PA3087_4 :BnPA3087 :GtPA3087 :PscPA3087 :

* 20 * 40 * 60 * 80 * 100 * 120 * 140 * 160MAYDIISDIHGCYDEMTALIQKLGYTEGRVLVFAGDLTDRGPKSIEVIRFVAGGAVRYVPGNHCNKLYRYLKGNPVKVKSVSEQFMKLYETAPLYDILELVVAHAGIRADDIGKYTRRVKGRPIRRD--WAAAYGKAWVVYGHTPVKEPRKVNRTINIDTGCVFGNMQFDIIGDVHGCYDELMELIDKLGYEDGRLLAFVGDLTDRGPHSLEVIRLVSHKTAYYVPGNHCNKLYRYMIGRKVQVIEVIAQFKELYEQAPLYHSFKLVITHAGIREDDIGSYGKRVEGTPVRRD--WAATYGDWWIVYGHTPVRRPRIIHRTVNIDTGCVFGGMKIDIIGDVHGCLEELEELLFKLGYQNNRQIVFVGDITDRGPDSIKVIKLVYQKLAYYIPGNHCNKLYRFFQGNKVMENNIKHKFIELYERSPLYLHLNVIIAHAGIPEHLIGKKDKRTKGKPIRRD--WAKHYGDSWIVYGHTPVLEPRVVNHTINIDTGCVFGNMKYDIIGDIHGCLQEFQNLTEKLGYNDQRKLAFVGDITDRGPHSLRMIEIVWEKVAYYAPGNHCNKLYRFFLGRNVTINMIKEKFITLYEQSPLYHVLRLLVCHAGIRQDYIGRQDKKVQGSPVRRD--WAKEYGTTWIVYGHTPVKEPRFVNHTVNIDTGAVFGGGPFDIIGDVHGCCDEVEQLLEKLGYREGRKALFLGDLVDRGPRILDTLKLVRNGSGMCILGNHEHKLIQKLAGKNVKVDQDIEEIQSFLKSLISHYVLKLVVAHAGLREELQGRGSGYVRGLPIRRN--WATDYGSAMVVHGHTPVATAEWLNNTIDIDTGCVYGLGPFDVIGDIHGCADELEDLLAQLGYREGRRAIFLGDLVDRGPRIPDVLKIVMSGTAFCVPGNHDTKLLRWLGGKDVKI---KKTVAKFLDSLIGHYVLKLVVAHAGMKESMQGRSSGAVRGLPVRFD--WASEYGSAMVVYGHTPVPQPQWLNNTINIDTGCVFGGGPFDIIGDIHGCYDELKMLLEKLGYLEGRKVLFLGDLVDRGPKITEVLKLVMGGIALCVPGNHDVKLLRKLSGRDVQI---IEEVKAFIDGLVSHYVLKLVVAHAGMKEEFQGRGSGKVRGLPVRYD--WASDYGKALVVYGHTPQAEVLKVNNTINIDTGCVFGGGPFDIIGDIHGCYDETVDLLTKLGYQQNRQVIFLGDLVDRGPGSPAVLKLVMSGVAWCVPGNHDLKLHKKLKGKQVAI---IGQVKEFLYGLVSHYVFKLVVAHAGIKEEMQGRGSGAVRGLPVRYH--WANEYGNAKVVYGHTPVPEAEWLNKTIDIDTGCVFGGGPFDIIGDVHGCYDELKNLLEKLGYRQERRIIFVGDLVDRGPNSPEVLRLVMDSIAFCVNGNHDDKLKRKLQGRNVVI---KASVLEFLESLSSYYILKLAVSHAGIKEKDLGRSSERISGLPLRYP--WDQEYGNTLIVYGHTPVCEAQWLNNTINIDTGCVFGGGPFDIIGDIHGCAGELESLLEELGYTEGRRAIFVGDLVDRGPRSPDVLRLVKGGTAFCVIGNHENKLVRKLNGRNVQL---AEEMRVWLDGLISHYVFKLVVAHAGLSEDMHNRASGKVRGLPVRAD--WAANYGRAKVVYGHTPTPEAEWVNGTICIDTGCVFGGGPFDLIGDIHGCFDELVSLLARLGYDKGRRLVFLGDLVDRGPDSPAVLRTVMSGRGHCVVGNHDDKFRRWLAGRDVKL---RRELLAFIDTLPHHLILRLIVAHAGVQADMHGEDSKRVRGLPVRLD--WARNYGEATVVHGHIAEPDVRERNNVICVDTGCVFGGRRFLVVGDVHGCRDELELLLAKAAYDTTTQLVLVGDLVNKGPYSAGVVRWCRERGALCVRGNHDDHAVDHWQKHFHL-KELSAADGAWLEALPHTLSLDAIVVHAGLAPDVPLDGQEPKHMTRMRSLASWAATRERPLVVFGHDAKRGLQVHANAVGLDTGCCYGKSRTILVGDVHGCLDELKSLLQACGFDSTDHVVLVGDLVNKGPHSAETVAYARESGFACVRGNHDDAALFAHEARTEAGDALGEADLAFLRELPHTLRLEVLVVHAGVVPGVPLAEQRAEDMTTMRNLVAWAEEWGVRHVVFGHDAKRRLQRHEHATGLDTGCCYGGQRTILIGDVHGCFVELKALLKKARFNQSDRLVLAGDLVGKGPYSRQVVEFVRKMGGIAVRGNHDHRAVKAHAGML---DELGAESLDWLATLPLSIFLKAYVVHAGVMPHTRVEQNTPELLMNLRGLEPWAQSWGPELVIFGHDATRRLQVHKYALGLDTGCVHGGPRVIAIGDVHGCITELQDLLRVCDYRG-DELILLGDLVAKGPDSQAVVQMAREIGARAVRGNHDHEVIRCREAMMRGHRQLSQQEHEWLRSCPWYIRSETVFVHAGFQPDVPFEEQLPRHMMNLRSVMAWARLWGPLRVVFGHDAYMGLQLWDKCIGLDTGCVYGGPRVIAIGDVHGCIDELQDLLRQCDYRPGDLVVFLGDLVCKGPDSISVVQMAREIGAFGVRGNHDFEVIRWHQAIKSGVSCLSKADMKWMNSLPWYLSSGSLFVHAGFVSGIRLAKQNPRLMMNMRSIWPWARLWGPQTVLFGHDADRGLQQYEHAIGLDTGCVYGGPYKGELGHVHGCIDELQALLRKCDYHPGDLVVFLGDLVCKGPDSLSVVQMAREIGAIGIRGNHDFEVVRWHQAIKSGASALSTADLKWMYSLPWFISSNALFVHAGFVSGIRLAKQNPRLMMNMRSIWPWARLWGPQTVFFGHDADRGLQQYEHAIGLDTGCVYGGPRIVAIGDVHGCVNEMKDLVRKVEYWPGDLLLFLGDLVAKGPNSAGVVRTARELGGVSVRGNHEFEVLRWLNVGENENMSLGEDDGLWLKNSPWYFQCDALFVHAGFIPGVSMKRQNPRMMMNMRSLRPWAREWGPDTVFFGHDAARGLQVLDQAMGLDTGCVYGGKRLIFIGDVHGCIDELQDLLKECDYSATDRVIFVGDLVAKGPDSQAVLQLAREIDALSVRGNHDEATLRVRHAWMNPGTTLKEEDWEYLSSLPYYLTIPCVVVHAGLAPGLPLRWQRPIDMMYMRVIVPWAGEWGPELVLFGHDAARGLQLWPHAVGLDTGAVYGGMRTLFIGDVHGCAEELDALLTRCGWRPDDRVVLVGDLVAKGPDSAGVVRRAREQGFLAVRGNHDAHVLRWHAGRGPRGDTLTPEDWAWLESQPLYRCFNVVAVHGGLVPGVPLEAQKEDELLNLRSIAPWASLWGPELVIFGHDAMRGLQRYPHAVGLDSGCVYGGMRTLFIGDVHGCAEELDALLTQCAWQPDDRVVLVGDLVAKGPDSAGVVRRAREQGFLAVRGNHDAHVLRWHAGRGPRGDTLTPEDWAWLESQPLYRFFNVVAVHGGLVPGVPLEAQKEDELLNLRSIAPWASLWGPELVIFGHDAMRGIQRHPHAVGLDSGCVYGGMRTLFIGDVHGCSSELDALLKACDWQPGDRVVLVGDLVAKGPDSAGVVRRAREHGFQAVKGNHDAHVLRWHGGHASKGDTLSAADWAWMERLPSYLRFNALAVHAGLVPGVPLEEQKEEFLFNLRSIEPWGSLWGPELVIFGHDAMRGLQKHPFAVGLDSGCVYGGMRTLFIGDVHGCAEELDALLAVCGWQPGDRVVLVGDLVAKGPDSAGVLARARERGLLAVRGNHDEHVLRWHQGYVKPGDTLAPEDWAYLASLPLYLRLNVVAVHAGMLPGVPLESQHREHLLNLRSIEPWASHWGPELVLFGHDAMRGIQRYPHALGLDSGCVYGGPRTIIIGDVHGCRDELARLIEHVGLVSGDRVVMVGDLIVRGPDPCGTLDLLREVGAISVRGNHEDRLLRWRAGRSDPRQQLRKRDWAWLETLPYWLDLGLRVVHAGLIPGLPIERQDPHTLMYVRCLTLWGQTYGPPHVVFGHNARSEPQMHAWATGIDTGAVYGG-RTMVIGDVHGCHRELQQMLARLSPGPSDRVVFVGDVISKGPDPVASLRLARNAGSEILVGNHERNLLTWLKQRDQGVEQLTRGEVEWLRGRPDRLALNAIVAHAGLRAGVPLAQQQHADLTAMRSLVSWAASWGPTHVIFGHDSRRRLQLHPFATGIDTGCVYGG------------MRATESLLGKLAFSARYRVVFVGDVISKGPDPVASLRLARNAGSEILVGNHERNLLTWLKQRDQGVEQLTRGEVEWLRGRPDRLALNAIVAHAGLRAGVPLAQQQHADLTAMRSLVSWAASWGPTHVIFGHDSRRRLQLHPFATGIDTGCVYGGGQIIVIGDVHGCPVELNALLDKCKFQGSDKVVFVGDLVNKGEQSAEAVHLARQIGGISVRGNHDEMALERYEMWKK--EQFSEEDVEYFRQMPFSLSIGVLVVHAGIVPGTPLEDQLLDDLINMRHVQPWANIYGPQHVIFGHHARRRLQPCRFATGIDTGCVLGDRRLLVVGDVHGCYDELVQLLDKAGGRPGVLVVFVGDVCNKGPLNVESIRLVREVGGYCVRGNHDEICLLEWLKHSEG-SRLSKEEMDWYFELPFSIHFEVLVIHAGLVPGVPIEEQSHHDLLHLRNVQPWAQTWGPDHVYFGHDAIRFLQRYPFATGLDTGCVYGGKRVFFIGDVHGCYDEMMQLLNKADALDDTVVIFVGDMVNKGPKSREVIDFLRRSKVYAVKGNHEDHVLREYDNSRDP-GKLTLEEAQYLRDLPYTISLNIIAVHAGLVPGRPLEEQSDYEMMTMRNLKPWAAEWGPQHVVFGHDAVRRLQLYDHATGLDTGCLYGGKRVFFIGDVHGCYDEMMQLLHKADALDDTVVIFVGDMVNKGPKSREVIDFLRHSKVYAVKGNHEDHVLREYDNSQNP-GKLTLEEAQYLRDLPYTISLNIIAVHAGLVPGRPLEEQSDYEMMTMRNLKPWAAEWGPQHVVFGHDAVRRLQLYDHATGLDTGCLYGGKRIVIIGDVHGCYDELQEMLDLTGARNDTVVLFVGDLVNKGPKSKEVVNLVRSKNAQSVRGNHDEAVLREYANREKDSTASDKSERDFLTNLPYTITVNILIVHAGLVPGKQLLQQKTQDMVTMRNAYPWASLWGPHHVYFGHDAKRKLQLYDYATGLDTGCVYGGKRIVIIGDVHGCYDELQEMLDLTGARNDTVVLFVGDLVNKGPKSKEVVNLVRSKNAQSVRGNHDEAVLREYANREKDSTASDKSERDFLTNLPYTITVNILIVHAGLVPGKQLLQQKTQDMVTMRNAYPWASLWGPHHVYFGHDAKRKLQLYDYATGLDTGCVYGGRPVFVVGDIHGCCDELEEIVTEARKEKDTLFVFVGDLVNKGPKNSEVLDFLESLGHYAVRGNHDEVILKELHKFNTQPKKLTRIQVEYLQQLPYTIQINSIIVHAGLIPGKPLELTDFNTFTNMRNIEPWTSLWGPEHVYFGHDAKRKLQLLPLATGLDTGCLYGG-RVVVIGDVHGCFDELQDLLRVHNLMEDTVLVFCGDIINRGPKNQEVIQFIRNMGAYSVRGNHEDRVIYEWLNFHKRSTTLSSEDIDFLCSLPYTLSIETIVLHAGMDPWKCLCKQQPKDLVLTRNIVPWISCWGPQHVYFGHDARRGLQERRFGTGLDTGCVYGNGRVMIVGDVHGCCDELEELLRLHH--EGDLLILAGDLVNKGPKSVEVVRLARRMNAMAVVGNHEISSLRGYFARSGGKDGLCVEDVEFIRSLPFTISINVIVVHAGLVPDLSLAEQDHRHMVTMRNLEPWAALWGPSHVYFGHDAKRRLQLYKHATGLDTGCLYGDRKVLIVGDVHGCLREMEELLQEAKSKQEILPIFVGDLLSKGPFPVETLKKLQKIEHYAVRGNHDEAVLRQALSLKKEEPNLSDDDIGYLRELPYTISISVIIVHAGLVPGIPLTEQELTNMIIMRNLEAWASFWGPDHVYFGHDARRKLQKHAHATGLDTGCVYGNGRLIIIGDVHGCVKELKELLEEAEYVGEDTVVLVGDLVDKGPYPLEVLAEARRLKFHSVRGNHDDEVLAAYEALAR--KDLPAAAAQWLHALPFSLRIGVTVVHAGIVPDVPLERQSLGDMYLMREVPPWAAVWGPEHIYFGHDHQRGLQERPYATGLDTGCCYGDTRLLVIGDVHGCFDELQLLLETCHFSLEDRLVFVGDLVNKGPKSLDVVRFVRESDSLCVRGNHDDAALSAYYKWVEGGEHFLPDDVEFLEQLPFSLSLDIIVVHAGVVADVELEQQKPFDLYKMRFVEMWAKVWGPRHVYFGHAASAGLQQESFATGLDTGCCYGKTRLLVIGDVHGCFGELQLLLEACDFRASDRLVFVGDLVNKGPRSLDVVRFARDSDALCVRGNHDDAALSAYYQWVQGGELLEEEDVAFLEQLPFSLSLNAIVVHAGVVDGVGLQQQKPFDMYKMRFVRMWAKVWGPRHVYFGHA----------------------SRLLVIGDVHGCLDELQALLAACHFAAGDRLVFVGDLVNKGPKSLDVVRFVRDSGALCVRGNHDDAALSAYYRWVQGGEQFEPRDVAFLEQLPFSLSLNIIVVHAGLVEGVELQDQKPFDMYKMRFVKMWAKVWGPRHVYFGHAASAGLQV------------GGGNRAGAPGRGSSCARELQLLLSACDFSPNDCLVFVGDLVNKGPKPLDVVRFVRESGSLCVRGNHDDAALSAFYQWINGGEHFKPEDVEFLEQLPFSVSLNIIVIHAGVVPEVNLEEQRPVDMYKMRFVEMWAKVWGPRHVYFGHAASAGLQVRRLLRRN--------VRAVIVGDVHACYEELLELLHACAFDASDTLVLVGDLVNKGPQPLEVVRFARETKALCVRGNHDDAALSAYYAWQANGEQFTPEDVQFLEQLPFTVTLNAIVVHAGLVPGVPLSAQQPRHMYKMRYLTQWATQWGPLHVYFGHDAVPGLQQEAFATGLDTGCCYGRKQVLIIGDIHGCYDELMKLLHSQRANKDTLKLFVGDLVNKGPKSEQVLDFIMGNNCQSVRGNHDEVVLREYLASRDP-GRLSGQQARFLQELPYTLSLNALVVHAGLVPGQGLATS-PRNMVSMRNLVPWGSLWGPAHVYFGHDAKRMLQTWPRCTGLDTGCVYGNKQVFVIGDVHGCYEELMDLLAVAKVKKHTLKLFVGDLVNKGPKSEEVLDYLISDRCHAVRGNHDEVVLKEYYASRSL-NRLTARHVRYLEQLPYTLLLNTVIVHAGLVPGQGLSTS-LADMVTMRNVEPWGQVWGPQHVIFGHDAKRNLQTWQHCTGLDTGCVYGNKQVFVIGDVHGCYEELMDLLAVAKARNDTLKLFVGDLVNKGPRSEDVLEFLMNNHCHSVRGNHDEVVLKEYYASRNP-KQLTVCQIRYLEQLPYTLIMNTVIVHAGLVPDEGLSTS-LVDMVTMRNVEPWGQVWGPHHVIFGHDAKRKLQKWRYCTGLDTGCVYGNKRIFVIGDVHGCYDNLLTLLHVADIDPNALLIFVGDIINKGPKSLEVLNFVRSSNSYSVMGNHERAAVRKLRLIKMNVHDLNGSDYEYLQELPYTISINAVIVHGGLLPGKPLEEHTQDEMLLMRNIQLWGELWGPRHVYFGHHALEGLQRYPYATGLDTGCVYHGRRVLVVGDIHGCYEELLDLLDKCSYAGEDVLVLVGDLVNKGPRSAEVLRFVRDGGVFAVRGNHDDSSLAAYTRLSSGDRDLDASLATVLEQLPFTLRLDALVVHAGLVPNIPVGEQRMMDLLHMRNVLAWASAWGPPHVFFGHDARRLVQLERCATGLDGGCVYGNSRTIVIGDLHGCYDEALELLEKVGATSQDRILFVGDLVDRGPKPRECVELAMR--HEAIQGNHEEKHLQQRHRAD---RALEPEHFDYMARLPFYLRLNAAVVHAGVMPGKRLEDQDPYHLLHAQCIRFWTHHWGPERIIFGHTVFDQPLVTPHAVGIDTGCVYGRRRTIVIGDLHGCYDEAVELLDKVGATSSDRVIFAGDLVDRGPKRRECVELAMR--HEAVLGNHEEKHLQQRHRAD---RVLEAEHYAWMAGLPHYLRLNAIVVHAGMLPGRPVEEQDAYHLLHAQCITFWTHHWGPERVIFGHTAFDAPLVTEYAVGIDTGCVYGHRRTIVIGDLHGCYDEAVELLGKVGATSSDRIIFAGDLVDRGPKRRECVELAMR--HEAILGNHEEKHLQQRHRAD---RVLQPGHYDWMARLPRYLRLNAIVVHAGMLPDIPVEKQDPYHLLHAQCITFWTHHWGPERVIFGHTVFDAPLVTEHAVGIDTGCVYGRGRYIIVGDVHGCVDQLEQLVEKVKYVGKDCLFIIGDYVNKGPDSIGAVRACQRLGAYGVLGNHDYTLLRCCVRMRR--QKLPKDCEYYLRGLPHIVRINVLLVHAGLNLQHSVENQNVEEVMHLRRLEPWAKLWGPEMVIFGHDAYAGFQAHAHACGIDTGCVYGDYRYIIVGDVHGCPEQLEELLLKVEFQGKDCLIHVGDLVNKGPDSLAVVQLVQAKGAIGVLGNHDFTLLNCIARVKG--STFPQGCEDYIRSLPHILRINVIVVHAGLNVENSLEKQNVHEIMHLRRLQPWGELWGPECVVFGHDARAGLQELPFAYGIDTGCVYGGHRYIVVGDVHGCPEQLEQLMLKVNYQGKDCLILAGDLVNKGPDSIGAVRVAQKLGAIGVLGNHDSTLLNCIARCRK--LSFPQGCQDYLRSLPHILRINVIVVHAGLNLNNSIENQDVFEIMHMRRLEPWAEHWGPEFVVFGHDARSGLQEHPFAYGIDTGCVYGSGRLVVVGDIHGCLAQLQGLLRAVSFKGSDTLVAVGDLVNKGPDSFGVVRLLKRLGAHSVLGNHDVKLLKLVKKIRE--LTVPVDVEVYLSQLPHIIRINVIVTHGGLHPQRPLDCQYIDEVTTLRNLVPWASLWGPETVVFGHDSRRGLQERPLAIGLDSGCVYGGGRVIIVGDIHGCRAQLEDLLRAVSFKGSDTLVAVGDLVNKGPDSFGVVRLLKRLGAYSVLGNHDAKLLKLVKKLGK--QSIPTDVETYLSQLPHIIRINVMVAHAGLHPQRPVDRQYEDEVTTMRNLKPWASMWGPETVVFGHDARRGLQEKPLAIGLDSRCVYGGGRVVIVGDIHGCLAQLEDILSVTDFAGRDQLITAGDMVNKGPDSFGVVRLLKSLGARGVIGNHDAKLLKLRKKIRK--MSLPQDVEEYLSQLPHILRIKILVVHAGLHVQHPLERQLVKEVTTMRNLVPWASLWGPETVVFGHDARRGLQRYPHAIGLDTRCVYGGRRTLVVGDVHGCSAELDDLLRAAGFAGRDRLVLLGDLLDRGPDPIGVLRRVRELRAECVLGNHEEKHLRYAAHEARR-AALRRDDLAWLAALPRTIALGWVAVHAGFLPGRPIAAQPPDWMVRLRYVEPWAEVWGPERVVYGHHPQSLVEPDTPALGIDTGCVYGGSRTLVVGDVHGCLGELEDLLAAARYEMRDRLVFLGDLVDRGPDPVGVVRRVRALGADCLLGNHEEKHLRYAAHEARR-LRLSPDDLAWMAALPRALRLGWLAVHGGLLPGRPLSRQPPDWLIRLRFLEPWAERWGPSSVVYGHHARDEVVVDEPAVGIDTGCVYGGSRTLVVGDVHGCLGELEDLLAAARYEMRDRLVFLGDLVDRGPDPVGVVRRVRALGADCLLGNHEEKHLRYAAHEARR-LRLSPDDLAWMAALPRALRLGWVAVHGGLLPGRPLSRQPPDWLIRLRFLEPWAERWGPSSVVYGHHARDEVVVDEPAVGIDTGCVYGGSRTLVVGDVHGCLAELEDLLVAARYEARDRLVFLGDLMDRGPDPVGVVRRVRALGADCLLGNHEEKHLRYAAHEARR-LRLSPDDLAWMAALPRALRLRWLAVHGGLLPGRPLSRQPPDWLIRLRFLEAWAQRWGPSSVVYGHHAREEVVVDEPAVGIDTGCVYGGGRLIVVGDLHG-TPELFTLLERLSFRSHDNLVLVGDLVNKGPASLRLLEALPGLGAVAVRGNHDDAALAAWLAWRQK-RDMSPAQADLLAQLPFTLAVGVAVVHAGLVPGVPLKQQKLWACYKMRNLQAWAPLWGAQHVFFGHDAKRRLQLAPHATGLDTGCVYGGGRLIIVGDVHG-TPELFRLLDSLRYNASDNLILAGDLVNKGPVSLAILDAVPKLGCWAVRGNHDDAVLSAWLQFRA--QDMTDEQAAVLLGLPFTVSVGITVVHAGLVPGVPIEQQDMWAMYKMRNVKAWGALWGPTHVFFGHDAKRRLQLHPHATGLDTGCVYGGKNILVVGDVHGCYNELLELHNKALNEPFQYVILVGDLCNKGPESAKVIRHVRLSNWFSVRGNHDDGALLATLGGR---EALSDDDVQFMADLPYTIKIDTIIVHAGLIPNREIETQEIKTMITIRDLVPWGTAWGPF-VIFGHDAKRKLQMYDNAIGLDTGAVYGGDKILLIGDIHGCLDELKALVSKATDEQFKAIVLVGDLCNKGPYSAQVIEYVRHLHWYAVRGNHDDRALAAAFGDE---KVLTDEDVVWMANLPYTIRIDVIVVHAGLIPNVDLEEQKLKTMLTVRDLIPWVAAWGPELIVFGHDAKRGIQLEEFAIGLDSGCVYGKKGILVIGDVHGCFHELLRLHEKAVQEQFQYVILVGDLCNKGPDSTNVIRHVRAPNWLCVRGNHDDGALAAALGDE---NVLSDEDVLWMANLPYTIRIDTLIVHAGLIPGVLLKDQSIETMITIREVFLWADVWGPERVIFGHDARRGLQQDKWTLGLDTGVVYGKRRIIVVGDIHGCPEELQALLDKVRYRGVDLLVSVGDLVNKGPDSEKVIKLAMESDCLAVRGNHDDSAYEAFRCWLDGKDIPKPKKQGWL---------GVIVVHAGLVPGVPLEQQGMLEMEKMRDVRAWAEVWGPQHVFFGHDAKRRLQLCPAATGLDTGCVYGGKEVLVFGDIHGCFDELQELLHKRKYSSTHVVLSVGDMVNKGPKSLDVLNWFYENGVYTVRGNHDDSMLVTLDKLKEGGNDITTEVHNWATRLPYTIEIDLLIVHAGIVPKLDMDQQTPFDMTRMRFVVQWATTWGPQLIVFGHDAKQGLQEEPFALGLDTGCCYGKDGVYVVGDVHGCRAELEQLLDELGVTEDDLVVFVGDLVRKGPDSAGVVSLVRNDNMFTVRGNNEEKLIRGTKE-----DALSGEQLAWIRNLPVAISWDSLVVHGGVDPRKPLADHTIDELENVRALPYWWEVYGPSRVFFGHTPLSAPVARRHAVGLDTGCVYGNEGIYVVGDVHGCHEELEQLLDELGVTDDDLVVFVGDLVRKGPDSEGVVSLVRNPNMLTVRGNNEEKLIRGDKR-----DELTEEQMEWIRNLPVAISWDAFVVHGGVDPQKPLSEHSIKELETFRKFAYWWEAYGPRRVFFGHTPLSAPVDRRYAVGLDTGCVYGNDDIYIIGDVHGCHDELNQLLSTLDVTDTDLVVFVGDLVRKGPDSKGVLEHVRHENMFTIRGNNEEKLLRGEKS-----PVLSSDDLSWIRSRPVGISWDTLVVHGGVDPRKELSEHTTYELQTFRSLPFWWERYGSDRIFFGHTPLAAPVYRECAIGLDTGCVYGNDDIYVVGDVHGCLSELETLLDELDPSDEDLVVFVGDLIRKGPDNHGVVDLVRSPNMISIRGNNEEKIIKGTKE-----DDLTEEDIDWIRNLPVAISWGALVVHGGVDPRMDLDDHTVDDLQNTRSLPFWWEEYGPAHVFFGHTVMREPAIADYALGLDTGCVYGGDDIYVVGDVHGCLSELETLLDELDPSDEDLVVFVGDLIRKGPDNHGVVDLVRSPNMISIRGNNEEKIIKGTKE-----DDLTEEDIDWIRNLPVAISWGALVVHGGVDPRMDLDDHTVDDLQNTRSLPFWWEEYGPAHVFFGHTVMREPAIADYALGLDTGCVYGGDDVYVVGDVHGCLPALERLVDRLEPSEDDLVVFVGDLVRKGPDSKGVVDYVREDNFLTVRGNNEEKLIRGTKE-----DALTDDDLEWISNLPVAITWDAIVVHGGVHPEKPLSEHSVDELENTRAMPFWFEYYGPERVFFGHTVMAHPAVFEYAMGLDTGAVYGGEDIYVVGDVHGCLPELESLLDDLAPSADDLVVFVGDLIRKGPDSIGVVELVREDNFRSVRGNNEQKLLDGDVE-----DEFGEAEIEYVRSLPAAISWDALVVHGGVDPRKPLSEHSIDDLETTRSLPFWFEEYGPRRVFFGHTVLERPVEREWAVGLDTGCVYGG---------HGCPEPLDRLLSTLEITDDDLVVFVGDLVRKGPDSAGVVERVRDDNMFSVRGNNEEKLLRGDKS-----ASLSDDDLAWIESLPVAITVENLIVHGGVDPRKPLAEHTIDDLQNTRSLPYWYEEYGPPRVFFGHTVLDEPVRSEWAVGLDTGCVYGGEEIYVVGDVHGCRPTLERLLNRLDPTPDELVVFVGDLVRKGPDSAGVVDMVRHPNFLTVRGNNEQKLIDGRKS-----PSLTDDDLSWMASLPVAISWDSLVVHGGVDHRKSIAEHELTELLNMRSLPYWFETRADPRIFFGHTVLSEPFETPTAVGLDTGCVYGGEDIYVVGDVHGCLSALERLVDRIDPDDDTLLVVVGDLIRKGPDSHGVVEFVREDTVVSVRGNNEAKIVRGDKE-----PGLTGEDRAYIESLPHAISWGNLVVHGGVDPRKSLGDHDPAELLTMRSLPFWFEEYDSPRVFFGHTVLAEPYESAGAVGLDTGCVYGGDEVYVVGDVHGCAETLERLLDRLD-NGRSLFVFVGDLVRKGPDSRRALSLVREDNLLSVRGNNEQKLLDGRAS-----DALDDDDLAFVESMPLVVSWGALVVHGGIDHRKPLAEHSAEELLNNRSLPYWFETRGGRTVFFGHTVLAQPFATPWAVGLDTGCVYGGSDIYVVGDVHGSRAALETLLSDLGLNDDDLVIFVGDLVRKGPDSPGVIDLVRESRLISVRGNNEQKVVRGYKD-----EWLRERDRAYFDSLPVVISFDALVVHGGVDPKQTLENHSVEELLTMRAPPFWYESYGPYRVFFGHTVHNRPVEREFAVGLDTGCVYGGDDVYVIGDVHGCLDALEQLLSTLEFGPNDLGVFVGDLVRKGPDSKAVLKRVRDPQLRSVRGNNEQKFLDDEAD-----EALEPADYRYLESLPTAISWDNLVVHGGVDPARSLSEHSDRDLLTMRSPPFWFDEYGPLRVFFGHTVLDEPVEREWAVGLDTGCVYGGDDVYVVGDVHGCPDALERLFSTLEFGSSDLAIFVGDLVRKGPDSKAVLDRVKSPQLRSVRGNNEQKLLDGRAE-----PALDESDRQYIESLPTAISWGNLVVHGGVDPSRPLLEHSNGDLLTMRSPPFWFDEYDGPRVFFGHTVLEEPLERECAVGLDTGCVYGGDEVYVIGDVHGCLDALEALLGTLELGANDLAVFVGDLVRKGPESKAVLDRVRRPRLLSVRGNNERKLLEGEAS-----SALDAVDYQYLESLPTAISWGGLVVHGGLDPSRPLSGHSDDDVLTMRSPPFWFDRYGPPRVFFGHTVLAEPIEREWTVGLDTGCVYGGDSVYVVGDVHGCLDALETLLSTLDLGENDLAIFVGDLVRKGPESEAVVDRIRAPQLMSVRGNNEQKLIDGTAT-----EEFGPSAQAYIESLPVAISWGGLVVHGGIEPSRPFTAHSSEELLTMRAPPFWFDEYGNPRVFFGHTVLEQPLDGERTVGLDTGCVYGG---------HGCRGALDELLATIGVDDDDLVLFVGDLIRKGPDGGSVVRFVRRENMLAVRGNNEQKLLDEEIT-----PSVGPSDRAYLRTLPDAIRWGGLVVHGGLDPEREVYAHTREELQTMRSPPFWFERYGPPRVFFGHTVLSAPIEDEWIVGLDTGCVYGG----------MCIPAVLKLGESASPSGADVCVFVGDLVNKGPDSYGVVRFLRDIGAIGVLGNHDAALLQLSEK-----LHCPDDVFAFMMSVPHILCFRLIVVHAGIDPSIPLAAQSVEAVTRMRNLANWSELWRRIHVVYGHDAKRRLQVYPYAYGLDSGCVYGGRPVVVIGDIHGCFDEFEELLVKIKDESTFQLFLVGDLVNKGPKSAEVVKKVRAGSTHVVRGNHEEALLEEWSTTN---SKLNSDDRLFLLQLPYTISVEWMIVHAGLDPQKSLEHQEPDYMVRMRNFEKWVIKWGEFRVIFGHDARRRLQQGNNYLGLDTGVVYGDRRLVVVGDIHGMLDPFEKLLKKIKFNETDHVIAVGDMINKGPKSSEVIARLMEIKASAVRGNHEDRVILAWRGLSS--RSLTEPQMTWLKRLPVILSAALYFVHAGLVPGVPLPQQDAWAVMNMRTLERWTKMWKEQKVVYGHDAKMGYQEDSYTFGLDSGCVKGNGRIIIVGDVHGHLPELKNLLQKVSYDNGDQLIFVGDLINKGPDSPGVVQLAMDYDALAIRGNNEDRVLAAYSAIKRGQANLSKEQITWLASRPLILRITLIVAHGGLVPHVSLEEQDPWAVMNMRSLLPWIDAWERSIVVYGHDARVGLQVSRYTFGLDSGCVYGRERLIVVGDVQGCMAELDRLLEELLFDTNDHLIFTGNMISQGPNSTDVVDFARKYSASCVRGNNEDRVLVMRHNMIEAQRALSDEQSEWLDACPVILNVQVAVVHGGLIPGVDLNHQDPYSVMNMLTLMMWTKFFGATTVIYGHDSETGLNINTYTKGIDTGCVAGGMATYLIGDVHGCYDELIALLHKVEFTGKDTLWLTGDLVARGPGSLDVLRYVKSDSVRLVLGNHDLHLLAVFAGISRNKAPDADELLNWLRRQPLLQIDKLVMAHAGITPQWDLQTAKECAFTRMRFCKPWFAIPEEYSIAFGHWASLGKGTPEGIYALDTGCCWGGMSTYLIGDVHGCYDELIALLKQVDFTGQDTLWLTGDLVARGPGSLDVLRYVKSDSVRLVLGNHDLHLLAVYAGISRNKAPDADELLNWLRRQPLLQIDKLVMAHAGITPQWDLETAKTCAFTRMRYCKPWFAIPNEYSVVFGHWASLGKGTPENIYALDTGCCWGGMSTYLIGDVHGCFDELQSLLAQVAFDQHDRLWLTGDLVARGPGSLDVLRYVRSPAVRMVLGNHDLHLLAVYAGISRNKAPDADELINWLRRQPVLQVDKLVMAHAGITPQW--------ALTRMRYCKPWFELPADYTIIFGHWASLGKGTPAGVIGLDTGCCWGGMSTYLIGDVHGCFDELMALLAQVSFNAHDRLWFTGDLVARGPASLEVLRYVRSPAAQMVLGNHDLYLLAVYAGISRNKARDVDTLINWLRSQPVMLVDKLVMAHAGVTPQWDLETAQLCAFTRMRYCKPWFYLPPGYAIAFGHWASLGKGTPDNIYALDTGCCWGGMATYLIGDVHGCYHELRALLAQADFDLADTLWLTGDLVARGPDSLDVLRYVKSDCVRLVLGNHDLHLLGIYAGISRNKAPDLDELINWLRRQPMLQVDKLVMAHAGITPQWDLDTAILCALTRMRYCKPWFALPEGYSVAFGHWASLGKGAPRGIYALDTGCCWGGMANLLIGDVHGCYQELRLLLDKANFDDLDTVWFTGDLVARGPDSLQVLRFIKSDKARICLGNHDLHLLAVHANISHLKAPDCDELMHWLRHQPIMQIDKLIMVHAGISPQWDLETAKKCAFTRMRYCKPWFMLPVEYSIAFGHWAALGQGTPDQIYALDTGCCWGGMATYAVGDLQGCLAPLKRLLDRVAFDANDRLWLVGDLVNRGPQSLETLRYLYSDSLVCVLGNHDLHLLAAGNNIERLKAPDRAQLLDWLRRQKLMHYDNMALVHAGIPPQWTLKKALKCAFTRMRFCKPWFAYKRDTKIIFGHWAALGKCDEPGVFALDTGCVWGGMATYAVGDLQGCLQPLKCLLERVRFDAVDQLWLVGDLVNRGPESLETLRYLYSQSLTCVLGNHDLHLLAAWRNVERLKAPDADQLLDWLRQQKLLHYDGIALVHAGIPPQWTLGKALELALTRMRFCKPWFAHKRHVTIIFGHWAALGQVKEPGVIALDTGCVWGGMARYAIGDIQGCYHSMMHLLAQVDFQGRDSLWLVGDLINRGTGSLEVLRWVYADHVRLVLGNHDLHAIAVAHHIRPPHADDGAALLGWLRQQPLMVLE-FAMLHAGLYPQWTLPEARALALTRMRLLQPWFKVAAQATILFGHWSALGLYQGEGVVALDTGCLWGR-----IGDLQGCYYSFINLLDACGFNKRDRLWLVGDLINRGPHSTAVLRWLKEANVTTVLGNHDLHALAVHEGFAEVHAADRDELFDWIRLQSLAYAE-YLIVHAGLLPQWDAQQARALAMTRLRVCLPWFDIKKKDTLIFGHWSALGLVLRKRLIGLDTGCLWGEMATYAIGDIQGCFTSLTALLNRIEFDARDRLWLVGDLVNRGPDSLQTLRFVRDASAVTVLGNHDLYLLMVAYGSVRARAPDRDALLNWLRTRPLMHLE-FAMVHAGLLPGWTAQRARALAMTRMRFCVPWFEAPADTTVVFGHWSALGLRVEPRLLALDSGCLWGRMATYAIGDIQGCFGPFQQLLRQIEFNGKDTLWLTGDLVNRGPESLQVLRWVFQDRVQIVLGNHDLHLLAVSEGFGKLHAADGKVLLDWLRCQPLMIAE-YAMVHAGLLPEWSIDKALRLAMTRMRFIIPWFEAKSHTPIICGHWSALGLHITEDILSIDSGCLWGG-----------------------------------------------------DRVRTVLGNHDIHLLAVAAGVRKSGAPDSVELITWLRHQPLAIRE-YLIVHAGVLPQWTAEQVTKLALTRLRYCMPWFEVPSDVTVVCGHWSTLGLVMRPNLIALDTGCVWGG----VIGDLQGCAHEAGLLLERIAADEEARVLFVGDLINRGPASLTALRRMKTGRVEALLGNHDLHLLAVAAGVQKTSAPDRDELIAWLRRRPLAMFV-HLLVHAGVPPQWSAEQTMRLALTRMRLCLPWFDVPADVTVVFGHWSALGLVLRPNLVGLDSGCVWGGMALYCIGDIQGCSDALERLLAHIGFSSRDTVYLLGDLVNRGPDSAAVLRRCMRGALRALLGNHDLHLLAAAHGTRRTSAPDRDALLGWLRRQPLARAHRLLMVHAGVLPSWSVDDTLALALTRLRFCLPWFDVPADTLVAFGHWSTLGWLNRPDLLALDTGCVWGGMAIYCVGDIQGCDSAFARLLETIGFSSRDIVYLLGDLVNRGPESAAVLRRCMRDSARALLGNHDLHLMAAAYGVRQPSAPDRAALLAWIAQQPLARQRTLLMVHAGVLPQWSAADTLAYALTRLRFCVPWFDAPRDVVVAFGHWSTLGWMSRADVLGLDTGCVWGGMAMYLIGDIQGCDSALERLTRLIDFSSRDTLYLLGDLVNRGPESADVLRRLMRASARCLLGNHDLHLLAVSYGVRKPGADDAPALLHWLHHQKLALLEKLLMVHAGVLPAWTATKTIALALTRLRYCVPWFDTPAGDAVAFGHWSTLGWLNRPDAFALDSGCVWGG--------------------------------------NRGHDSLGTLRLLRDSAATCLLGNHDLHLLAVAHGIRKAHAPDRAAWIDWLRQRRMALHA-WLMVHAGVPPPWTLNTTLQLALTRTRYVQPWFEHPQGVPIAFGHWSTLGLIQRHDLLALDTGCVWGG-----IGDLQGCYDVTQRLLEKIRFDAQDTLWFCGDLVNRGGQSLETLRLVHSEHSVVVLGNHDLSLLAVGARTEEEQAEDRDELLDWLRLQKLVHVDGWMMVHAGLAPKWTTQMAEKHALTRMRYCYPWFEVPRDLKVVCGHWSALGLTITQGVHAIDTGAVWGG-----IGDLQGCYDVTQRLLEKIRFDAQDTLWFCGDLVNRGGQSLETLRLVHSEHSVVVLGNHDLSLLAVGARTEEEQAEDRDELLDWLRLQKLVHVDGWMMVHAGLAPKWTTQMAEKHALTRMRYCYPWFEVPRDLKIVCGHWSALGLTITQGVHAIDTGAVWGGMSVWAIGDLQGCYDVTQRLLEKIRFDAQDTLWFCGDLVNRGGQSLETLRLVHSEHSVVVLGNHDLSLLAVGSRTEEEQAEDRDELLDWLRLQKLVHVDGWMMVHAGLAPKWTTQMAEKHALTRMRYCYPWFEVPRDLKVVCGHWSALGLTITQGVHAIDTGAVWGGMATYAVGDLHGCYKSLRRLIDKIDFSERDRIWFTGDLVSRGNQSLEVLRYVKSDSAVCVLGNHDISLIASHYGVTKP-ADDREELISWLRQLPLLHSDGYCMAHAGVYPHWSWRQAEQCAFTRMRGCYPWFSLPLPYKVVFGHWSALGYRHNSQVISLDTGCVWGRMSNYVVGDIQGCFRELEALLTQVSFNANDSLWCVGDIVARGPSSRDALRFFYENSVHSVLGNHDLNLMAVLLGYRQPNDSDRYDWLEWLRHQPLMHQLNTVITHAGIYPWWTLKQASQYAFTRMRYCKPWFNFW-ENRVLFGHWAALGETRRQDVIALDTGCVWGQMAVWAVGDIQGCYGAFRKLLEEIDFDKRDKLWLAGDLVNRGDGSLETLEYIYSESVEVVLGNHDLSLIAAYYGIKKS-SPRAKELIDWLRSQKFLHVDGYCMAHAGISPEFDLGMAIRYAFTRMRFCKPWFECEIDLKIIFGHWSTLGFYQDEHVLALDTGCLWGG---YVIGDVQGCFEALKALLKEIQFDDQDFIWFAGDLIARGENSVGALRFIKKGNAATVLGNHDLNLLAVARGIKKLKALESDELIDWLRKQPLCLFPKTILTHAGIPNIWNAEKTAALALTRMRLTQPWFKFEKTHQIVFGHWAALGERINAQIQNVDGGCVWGH---YVIGDVQGCFEALKALLKTIQFDDQDFIWFAGDLVARGENSLGALRFIKKNAAATVLGNHDLTLLAAARGIKAIKAIDSDDLIDWLRKQPLCVFPTTVLTHAGIPTNWTAEQTAALALTRMRLTKPWFEFAQTHKVVFGHWAALGKTISDSIQNVDGGCVWGHMADYIVGDIQGCLSGLKVVLSKVDFAGKDTLYAVGDLIGRGPESLETLGYLHGDSFHTVLGNHDLNLLAIFCGVRRAKSDRFAKYCHWLRQKPLALSLNTLLTHAGLYPKWSFDKALGLSFTRMRFLTPWFSVNTQQRVVFGHWAALGETQNSHFIALDTGFVWGGMAQYVIGDLQGCFKEFKAILATLAFNSQDTLYLVGDIVARGPDSLSCLRFIKDSSVKTTLGNHDLHLISTFLLNKQPNAPDRNELIEYLQARPLALFLNSLVCHAGLSPEWTLAQALKAAFTRMRYFIPWFELPNDLTVIFGHWAALGKTNSNQFQAIDTGCVWGQMADYAIGDLQGCFNEFNALLQRVNFNSKDHLYLVGDIVARGPDSLACLEYLYKNSITVTLGNHDLHLIACYLLNKPPNSTKLPHYIAFLQTQPLALYLNSFISHAGLNPDWSIAQALQHAFTRMRFLTPWFMHPAKQTLIFGHWAALGKTPHNHLLALDTGCVWGGMATYAVGDLQGCFHTFNSLLDKISFNNSDELWLVGDLINRGLNSLEIIHWCYQKNIKLVLGNHDLHFLSVALSNHKVSSPYKRVFTDWLISIPLLHHS-HIMTHAGLLPSWKTSQAIALALTRMRCLKPWFSIPREVALITGHWSAVGFVKHASGYSLDSGCVWGKTATYAMGDLQGCYVPFAALLEQIDFTQTDRLWLAGDLVNRGPDSHAVINQLYADRVQIVLGNHDLYALARWAGITAAKDPHTDDWMEWLRTRSLLHTDGWSMVHAAIHPDWDMASARGHAFTRARYVAPWHERFTSESIICGHWATQGLLVQPRLLALDSGCVWGRMATYVIGDVHGHYTALMRLLDKIHFSGSDELWFLGDLINKGPDSLAVVRFVSQARHKVVMGNHDFSLLVQAAYPSLQMAADGADLLAKMRQWPLMFVDKIIVSHAGLYPNWTVEQALSLHLTRMRFFIPWYELK-GYRCIFGHWAALGLKIRESWACLDDGAAWGGMTTYALGSVNGDYQALMTLLDKIAFNDIDCLWFSGNLAG-GPESLAVLRLVKDKKAVTVLGNAELQLLQRAAGIVEPSAPDREELLKWLRQRGLMHHDNFTLVHAGIPGAWSFSQALTFAYTQMKYCMPWYRQPAHLHILFADDAGFADQPCPGIYPLSS------MAVYAIGDLHGCLDELQRLLALIRFDAADRLYFTGDLISRGPHGLDCMRLVQSAQAVTLLGNHEVRLLALEHGALPASAEDRSSLYQWVRQMPLMVQERAYMVHAGIPAHWSLAQAQALALTRMRLCQPWFAQRAGEKVLYGHWAMAGLQLKQHSLGLDSGCVYGGMSTYIIGDIHGCADELNRLLRKIKFNLYDKLILAGDLVGRGPASEEVIAQLMEDAVVKVLGNHDLKLLATHYGLAAPKSPRAKDYVAWLEDAKFAHWDAVIVVHGGIPLNWPVSQLRKQVLTRVKFVYPWYACRAGYKIVFGHWAALGMTISDYYICCDDGCVWGGPKLAVIGDVHGSAGQLSALLARLP--AGYEPIFVGDFVDRGPDPVAVLDTLIANRFRAVKGNHDDKLFRALKGNPVQVAPWRERLMVWLAELPTVLLFGIAVVHAYWSPTCPPDEHLWGPIYRIR----WWSVWPGIQVVFGHYHMP--VVTPQAVCVDFGAPEG-RGYDLIGDVHGCAHTLDRLLDLLGYR-RRQALFLGDIVDRGPRIREALHRVHAGEALCIMGNHEFNALGWSTPAAPGSDADWRDFLGWFQQLPLFLDARFRMVHAC----WDGELIATLRRAFFRTK--FWVEADEPLLFVGHYWRPAPI-RPNLACLDYSAVMYG-MYDLIGDIHGHATELKALLAKMDYR-ERTVIFLGDFVDRGPEQVETVTIAQNGHALAVMGNHEFNAVAWATEDPQNLSELHHSMIEWFKTLPVYLDLEFRVVHAC----WHPEHLAAIARTNIRTE--WWREDGEKPLFVGHYWMPAPL-NERIACLDYSVATGGMKVDFIGDIHGHAVELASLLIKLGYNEGRKVVFVGDYIDRGLQIRETLEIVKGKTADAVMGNHEYNAILFHAKNKKNGQEELKMYLEWFKNLPLFIETNYRVVHAY----WNKKHIEFLRRDKCRVK--WWHYPDDKPIFFGHYWLP--TLKSNAKCLDYSVAKNG--VDIIGDIHGHADKLEELLLKMDYKDYRKVIFVGDYIDRGPNNLRVLELVRSGNAMALCGNHEHNAICFNTKVDTG-QALYDETIEWFKSLPLFYETSFRVVHAT----WEENAINYLKRTDIRIK--WWLNEFQMPVFFGHYWLKGAPNRNNICCLDYSVA---MIYDVIGDIHGHADKLKGLLDKLGYKPNHRAIFIGDLIDRGPHEIETLQLVFAGVADALMGNHEYNALAYATVDDMAESEAHNYWLTRFYELPLWIETHACFVHAC----WDVDSMAVLKRHRMRVK--WWQQ-TDKPIFVGHYWLPEPL-SPQVVCTDYSVAGQGSVTDIIPDIHGQAEKLRVALRNLGWQPDREIVFLGDFIDRGPENAAVIRIVREGRARAIMGNHELNALHFHTKDPET-APHTKDVLDWMKGLQLFIEAGFRAVHAA----WIQSDVDRLRRRDIRVK--WW--AKEKPVFFGHYWMPVLQ-TENALCLDYSAGKDGDGLIFIGDLHGQYQKLIDLLEQLDFNEFSKLVFMGDLIDNKPEQVETLELVKSGHAYCLLGNHEFNAVCWASAHPLTDSRLHMKWIEWFKTLPLFIDFDVRAVHAC----WDDVAIQRVLRHHIRVR--WWII-QTIPVVIGHYTLPGPL-NAKVACVDYNAAEDGNKYDVIGDVHGYADELEVLLKKLGYQQGRQVIFIGDLIDKGPKIRQVLEIAKSGTALAVLGNHEYNAICYHTMDRSGLESEWKTYLKWFRSLPIYLNLGLNIVHAC----WDEKYIGFLERSRIRTQ--WWLSPNTGLTLVGHYTFKNEAANERIACLDYSGA---SGYDVIGDVHGCASQLEVLLHKLGYE-ERQAIFVGDLIDRGGEQLRVLEVVKAGSALIVMGNHEFNALAYHTEWPVGSGEDRQRCLEWFATIPLWLDLELRVVHAC----WHDDSIGVVERDNARVQ--WWNS-AEIPVFYGHYWRPKHRHTDYTACVDFSAVKGGGRFDFIGDIHAQYEKLTDLLTHCGYI-YGRLVFLGDLIDNKPDHLSLLNHIKDRLAYCVLGNHEFNAIGWSLKKPDG-SRQYHQWIEWFKTLPLFMDFDVRVIHAC----WHQESIDRIRRKNIRVG--WWKAEQDVPVVVGHYTLPYCV-GDKVVCVDFNAAPGKAGYDFIGDIHGQHGKLLQLLHKLGYEEGRIPVFLGDLLDRGPDVRGLVHRVRTDAAFCILGNHEYNFILLHTPDRQG-EEELTGHLHWMKGLPLALDLKCRAIHAC----WDDALLNRVARRNMRAR--WWN-AEAPPVFFGHYWMKAPL-APNLACLDYGAGLGGGKIDVIGDIHGEAGALTTLLDRLGYDDGRRLVFVGDLVDRGPNSVAVCDVVRGGNAQMVLGNHELNLLLGKHKHGNH-EEWRKKTLDFFRSQPVILERDVIVVHAAILP----ESLKALR---------WDDTKGKE------------------GGAGSGCVLGGGPVDIIGDVHGEIGALLSVLDVLGYNEGRRLVFVGDVVDRGPDSVRCLQVVRGGRAQMVLGNHELNLLRGSRKHGNL-EAFREEALSFLRKLPLVLERDCRVVHAC----WDDESISKLRRDVDRNR--WWNKEEEKLVVFGHYWR-------RACCIDYSVGLGTGPLDIVGDIHGEAEALEHLLGHLGYDQGRRLVFVGDFCDRGPDSPGVLARVVPGHALAVLGNHEINLLREDAKDGSG-LCDIPDTLALLERLPIAMERDLRVVHAAWRP----QQIAMARRFVERVA--WWNEYDAQAVVVGHYWRQGPLSGRRVFCVDYS--VGG

Supplemental Figure S3 GDxHG GDxVDRG GNHE HGG

VxFGH LDTG Motif 1 Motif 2

Supplemental Figure S3: Alignment of the phosphatase domain of ALPH protein phosphatases from both Prokaryotes and Eukaryotes. Candidate ALPH phosphatase sequences identified as detailed in Materials and Methods were aligned using MAFFT. The alignment was visualized in GeneDoc and manually edited to remove the extreme N- and C- terminal regions outside the protein phosphatase domain, plus poorly aligned regions, prior to phylogenetic tree inference. Two conserved bacterial-like phosphatase motifs (orange) were identified in addition to the known canonical PPP-family protein phosphatase motifs (blue). Of the two bacterial-like PPP-phosphatase motifs, Motif 1 represents a novel region of conservation. Motif 2 was previously reported (Andreeva and Kutuzov, 2004). The gene identifiers of each sequence used here are located in Supplemental Table S1.

Page 4: Supplemental Figure S1 - Plant physiology · 2013-10-09 · Supplemental Figure S1 . Mglo SLP : Um SLP : PgraSLP : MlarpSLP : RgluSLP : BdenSL P: TgSLP : CparSL P: LbSL P: CneoS LP

Supplemental Figure S4

CpSLPA6G215 9DELT

EhSLPaLmSLPcTcSLPb LmSLPb

TcSLPaLmSLPaTcSLPc

TbSLPaPmSLPa

MpSLPgOlSLPd

VcSLPcCrSLPc

A5FYZ4 ACICJ

C7JGL0 ACEP3Q5FPF8 GLUOX

G2I4P6 GLUXN

A9HIJ4 GLUDA

C7PBV5 CHIPD

G8XAS9 FLACAA4CIK5 ROBBHA4APQ2 MARSH

E6X796 CELAD

F7UVF4 EEGSY

F2N9L1 CORGP

C7N2D2 SLAHDC7N0S7 SLAHD

A3IN61 9CHROG6H040 9CHROC8W9T6 ATOPD

B8HLS9 CYAP4

B0JIT7 MICANB1WW02 CYAA5

E0UG92 CYAP2

H8MYK0 CORCM

F9YU86 CAPCC

F4KVD8 HALH1

A6L339 BACV8

A6LG58 PARD8A8FSQ7 SHESH

A0KU52 SHESAA6WR58 SHEB8

A0Z563 9GAMMSpSLP

PvxSLPaPchaSLPb

PbSLPa

PvxSLPbPchaSLPa

HcSLPHcalSLP

G0LIG8 HALWCQ18I99 HALWD

TtSLPPutSLP

PiSLPPcapSLP PrSLP

FcSLPEsSLPb

GtSLPaGtSLPc

ZmSLPc

ZmSLPe

CpaSLPbMpSLPeOlSLPb

OtSLPdOrcSLPc

GtSLPdGtSLPe

CrSLPaCocSLPaOtSLPc

BrSLPbMdpSLPe

Eukaryotes

Myxococcales &

γ-Proteobacteria

α-Proteobacteria

Other Bacteria

Outer Myxococcales

Inner Myxococcales

Archaea

F

E D

B C

A

Supplemental Figure S4: Phylogenetic radial tree depicting SLP protein phosphatase distribution and interrelationships across Eukaryotes, Archaea, and Bacteria. A radial depiction of the orthogonal tree presented in Figure 1. Insets highlight key evolutionary nodes depicted within the tree. Sequences from eukaryotic SLP phosphatases (green), α-Proteobacteria (purple), γ-Proteobacteria (blue), Archaea (black) and other bacteria (red) are highlighted. "Inner Myxococcales" and "Outer Myxococcales" are highlighted in orange and are explicitly labeled on the tree. Sequences used in multiple sequence alignment and phylogenetic tree generation are listed in Supplemental Table S1.

Basal Eukaryotic SLP Phosphatases

SLP1, 2 & Other Eukaryotic SLP Phosphatases

Inner Myxococcales

Basal Eukaryotic SLP Phosphatases

Outer Myxococcales

α-proteobacteria

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Supplemental Figure S5

0.1

E0TGJ0 PARBH

E8L7W5 9RHIZ

F2IW59 POLGS

G8API0 AZOBR

G7ZAB6 AZOL4

D3NZT3 AZOS1

E3I2B3 RHOVT

H5YEZ7 9BRADA7HLU4 FERNB

H9UCV4 FERPDA9BIC6 PETMO

H2J819 MARPK

Q11UR6 CYTH3

F4B184 KROS4

C7QL34 CYAP0

E0UA25 CYAP2

B0JSQ6 MICAN

B1WQZ5 CYAA5

B8DK70 DESVME1YER6 9DELT

G7Q752 9DELT

Q3A7H2 PELCD

F2RD99 STRVP

E4N448 KITSK

E4NEL1 KITSK

F8JTJ0 STREN

E8UQ78 STREJ

B7HV78 BACC7

Q8YZT4 NOSS1

Q3M5P0 ANAVT

Q8YP31 NOSS1D7E399 NOSA0

B2J0C0 NOSP7

B0C4K2 ACAM1

Q31LV8 SYNE7

D3QFL2 STALH

B9DJA7 STACT

GammataRLF

E8R2G2 ISOPI

F0SP41 PLABD

D5SSG4 PLAL2NgRLPH

BnRLPH

SrRLPH

MpRLPHb

MpRLPH

SmRLPH

PvRLPHPtRLPHc

CsatRLPHbGmRLPHb

MdpRLPHb

AlRLPHc

Other Bacteria 2

Other Bacteria 1

α-Proteo bacteria

Eukaryotes Planctomycetes

Eukaryotic RLPH

Phosphatases

α-proteobacteria

Planctomycetes

D C

F E

B

A

Supplemental Figure S5: Phylogenetic radial tree depicting RLPH protein phosphatase distribution and interrelationships across both Eukaryotes and Bacteria. A radial depiction of the orthogonal tree presented in Figure 2. Insets highlight key evolutionary nodes depicted within the tree. Sequences from eukaryotic ALPH phosphatases (green), α-Proteobacteria (purple), Planctomycetes (blue), and other bacteria (red and black) are highlighted. Sequences used in multiple sequence alignment and phylogenetic tree generation are listed in Supplemental Table S1.

Page 6: Supplemental Figure S1 - Plant physiology · 2013-10-09 · Supplemental Figure S1 . Mglo SLP : Um SLP : PgraSLP : MlarpSLP : RgluSLP : BdenSL P: TgSLP : CparSL P: LbSL P: CneoS LP

D4GUB7 HALVDE7QTB4 9EURY

NatrialbaHalovivax

Natronorub

I7BUV9 NATSJ

D2RRW5 HALTVHalosimple

G0I0G4 HALHTC7P488 HALMD

Halosarcin

A7HDV6 ANADFQ2ILE6 ANADE

EhALPHcQ097S7 STIAD

CmALPH

EsALPH

FgALPHb

FgALPHa

AnALPH

LmALPHaLmALPHbTbALPHb

TcALPHbTbALPHa

TbALPHcAqALPHOdALPH

CgALPH

BfALPHbSpALPH

LgALPH

IsALPHAmALPHRpALPH CocALPHa

CocALPHb

CvALPHbSaALPH BnALPH

PtALPHb

FcALPH

Q0ALJ2 MARMMPrpE 9PrpE 8

PrpE 2PrpE 1

PrpE 3

PrpE 4

PrpE 7

PrpE 10

PrpE 5

Q7NN25 GLOVIPA3087 10

PA3087 4

PA3087 1

PA3087 3

PA3087 2

PA3087 8

LsPA3087

PA3087 7PA3087 6

PA3087 9

PA3087 5 PscPA3087BnPA3087

A0L5C1 MAGSM

ApaH 2ApaH 7

CarApaH

ApaH 5 ApaH 6ApaH 8

F9ZYF7 METMM

SrApaH AstApaH

HmApaH

XtApaH

PscApaHaHvApaH

PtApaHAaeApaH

RcApaHb

ApaH 10RcApaHaAgApaH

SsApaHb

ApaH 4

ApaH 3OsApaHb

Supplemental Figure S6

Living Archaeal ALPHs

Eukaryotic ALPHs

Ancient Archaeal Ancestor

Eukaryotes

ApaH PA3087

PrpE

Archaea

Inner Myxococcales

Outer Myxococcales

I

H

G

F

E

D

A

C B

Supplemental Figure S6: Phylogenetic radial tree depicting ALPH protein phosphatase distribution and interrelationships across Eukaryotes, Archaea and Bacteria. A radial depiction of the orthogonal tree presented in Figure 3. Insets highlight key evolutionary nodes depicted within the tree. Sequences from eukaryotic ALPH phosphatases (green), Archaea (black), PrpE (pink), PA3087 (red) and ApaH (blue) groups are highlighted. "Outer Myxococcales" and "Inner Myxococcales" are highlighted in orange and are explicitly labeled on the tree. Sequences used in multiple sequence alignment and phylogenetic tree generation are listed in Supplemental Table S1.

Proposed Ancestral Archaeal

ALPH Root

Eukaryotic ALPHs

Outer Myxococcales

Ancient Archeal Ancestor

Page 7: Supplemental Figure S1 - Plant physiology · 2013-10-09 · Supplemental Figure S1 . Mglo SLP : Um SLP : PgraSLP : MlarpSLP : RgluSLP : BdenSL P: TgSLP : CparSL P: LbSL P: CneoS LP

D3QFL2 STALH

C7JGL0 ACEP3Q5FPF8 GLUOX

G2I4P6 GLUXN

A9HIJ4 GLUDAF0IZ02 ACIMA

Q1D163 MYXXDF8CJ73 MYXFH

A6LG58 PARD8

A6L339 BACV8G8T712 NIAKG

F9YU86 CAPCCF4KVD8 HALH1

B8CJM1 SHEPW

TtSLP

PutSLPPiSLPPsSLP

PrSLP

SpSLPLbSLP

PvxSLPaPchaSLPb

PvxSLPbPchaSLPa

PbSLPb

LmSLPbLmSLPc

TcSLPc

BdSLPbOsSLPb

ZmSLPc

ZmSLPe

ZmSLPdMgSLPc

PperSLPa

OlSLPb

ThalSLPb BrSLPb

MpSLPdA6G215 9DELT

AaSLPaGtSLPa

FcSLPCrSLPc

VcSLPcMpSLPhOlSLPd

E4N448 KITSK

F2RD99 STRVP

E4NEL1 KITSK

B3Q125 RHIE6F7UVF4 EEGSY

F4B184 KROS4A4CIK5 ROBBH

A4APQ2 MARSHC7PBV5 CHIPD

GammataRLF

E8R2G2 ISOPI

F0SP41 PLABD

D5SSG4 PLAL2

NgRLPH

BnRLPH

SrRLPHMpRLPHa

MpRLPHbGmRLPHb

EgRLPHAlRLPHc

PtRLPHb

MdpRLPHb

OsRLPHPscPA3087

PA3087 8

PA3087 2

PA3087 5

PA3087 9

PA3087 6

PA3087 7

PA3087 3

PA3087 4

PA3087 1

PA3087 10

PrpE 8

PrpE 1PrpE 2

PrpE 3

PrpE 4

PrpE 5ApaH 2 PscApaHa

ApaH 10ApaH 5ApaH 6

ApaH 8ApaH 4

A0L5C1 MAGSMSrApaH

HhApaHHalovivax

NatronorubD2RRW5 HALTVI7BUV9 NATSJ

G0LN38 HALWC

B8JET4 ANAD2A9ER55 SORC5

F8CMG1 MYXFHLmALPHb

LmALPHaTbALPHaCtALPHCgALPHSpALPHLgALPHRpALPH

SaALPH

ALPH Phosphatase Region

SLP Phosphatase Region

RLPH Phosphatase Region

Planctomycetes

Inner Myxococcales

Outer Myxococcales

Outer Myxococcales

Inner Myxococcales

Eukaryotic ALPH

Phosphatases

α- Proteobacteria

Eukaryotic SLP Phosphatases

α- Proteobacteria

Eukaryotic RLPH Phosphatases

Archaea

A

B C

Supplemental Figure S7: Phylogenetic radial tree depicting SLP, RLPH and ALPH protein phosphatase distribution and interrelationships across Eukaryotes, Archaea, and Bacteria. A radial depiction of a maximum-likelihood phylogenetic tree (PhyML, 5 random starts) inferred from a combined sequence set composed of all three classes of bacterial-like phosphoprotein phosphatase sequences. The eukaryotic SLP region is colored green, and the associated α-proteobacterial sequence cluster is labeled 'α-Proteobacteria'. The eukaryotic RLPH region is colored yellow, and the associated α-proteobacterial sequence cluster is labeled 'α-Proteobacteria', with branches denoted with purple circles. The eukaryotic ALPH region is colored blue, and the associated archaeal sequence cluster is labeled 'Archaea'. Support for the labeled nodes (aBayes support) is as follows: Node A (0.997) [α-Proteobacteria plus SLP radiation]; Node B (1.00) [α-Proteobacteria plus RLPH radiation]; Node C (0.999) [Archaeal ALPHs plus ALPH radiation]. In the SLP sequence region and the ALPH sequence region, "Outer Myxococcales" and "Inner Myxococcales" are both clearly indicated in orange and red, respectively. In the RLPH sequence region the associated Planctomycetes bacteria are highlighted in green. Sequences used in multiple sequence alignment and phylogenetic tree generation are listed in Supplemental Table S1.

Supplemental Figure S7


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