Blood glucose regulation

Dr. Sadaf Mumtaz14/02/11

• Insulin is associated with energy abundance

• Unbound form

Liver phosphorylase

glucokinase

Glycogen synthase

Liver cells

Phosphorylase & Glucose phosphatase

Glucose transporters

ERCa2+

IP3

Glut 4

receptor

Agonist Ca2+

Glucose

Tyrosine kinase

Fat metabolism

Glucose

Pyruvate

Acetyl CoA

Citrate, isocitrate ions

Acetyl CoA carboxylase

Acetyl CoA

Malonyl-CoATriglycerides

Lipoprotein lipase

Fatty acids Hormone sensitive lipase

Α-glycerol phosphate

Ketosis

Protein metabolism

Mechanism of insulin secretion

Sulphonylurea drugs

Glucagon

• Glycogenolysis• Gluconeogenesis

• Adrenal diabetes

• Pituitary diabetes

• Gestational diabetes

Thanks

Volunteers for OGTT