Process for approving FAO-OIE rinderpest holding facilities and research proposals

Maintaining Global Freedom from Rinderpest International Meeting • 20-22 January 2016 • Rome, Italy

Process for approving FAO-OIE Rinderpest Process for approving FAO-OIE Rinderpest Holding Facilities and Research ProposalsHolding Facilities and Research ProposalsSamia MetwallyAnimal health officer (Virology)Animal health officer (Virology)Animal Production and Health DivisionAnimal Production and Health DivisionFAO, Rome ItalyFAO, Rome Italy


FAO-OIE Rinderpest Holding FacilitiesCategories

• A) Rinderpest Holding Facility for storing rinderpest virus containing material, excluding vaccine stocks;

• B) Rinderpest Vaccine Holding Facility for storing only manufactured vaccines, vaccine stocks and material solely for their production.


Rinderpest virus-containing material (RVCM)Risk rank

• High Risk– field and wild isolates stored in any form stored in frozen status, or in

lyophilized status

• Potential Risk– vaccine stocks stored in good conditions which were produced where

wild strains were manipulated- cross-contamination

• Not potential risk– vaccine virus (with documented history to be safe) – field sera and samples with RP history that have been immersed in

fixative and preserved over decades


FAO-OIE Holding FacilityCategory A: mandate, (RVCM-excluding vaccine)

• hold and accept RVCM from FAO and OIE Member Countries

• retain an up-to-date inventory of RVCM and provide an annual report

• provide advice or training on the destruction, safe shipment of RPV-containing material, and/or decontamination of facilities

• participate in scientific meetings in its capacity as FAO-OIE RHF

• establish and maintain a network with other rinderpest holding facilities

• seek approval from FAO and the OIE before manipulating RVCM

• Cooperate with FAO and OIE when decide to carry out an audit or site inspection


FAO-OIE Holding FacilityMandate (Category B- vaccine)

• retain an up-to-date inventory of vaccine stocks for the region

• validate or destroy stocks of expired vaccines

• regularly test the quality of the vaccines in accordance with the OIE guidelines

• contribute, when requested by FAO and the OIE, to the global rinderpest vaccine bank and preparedness strategy

• accept vaccine virus seeds or stocks from FAO and OIE Member Countries for safe storage and/or for destruction


Process for Approval of FAO-OIE Holding Facilities


Site Inspections of Holding Facilities

FAO-OIE Rinderpest Holding Facilities

ApprovedCategory ACategory B

PendingCategory ACategory B


Approval of Rinderpest ResearchObjectives of the research proposal should meet one or more of the following criteria:•Protect or improve food security•Sustain effective and efficient global freedom from rinderpest •Provide significant scientific benefits for public health or animal health

Review of research proposals should account for the following factors:•Scientific and technical merits of the proposal and methodology are valid and feasible•Whether the use of RVCM is essential for the research•Has significance to the post eradication era •Adequate biosecurity and biosafety measures in place•Appropriate animal welfare standards•Potential for malign use of the research outputs has been considered•Principal investigators’ knowledge, capabilities, related experience, past performance and qualifications


Rinderpest Research Projects Approved

1. “Testing the potential for protecting cattle against rinderpest virus using attenuated peste des petits ruminants virus vaccines”. The Pirbright Laboratory. Completed

2. “Development and Deployment of non-infectious diagnostic test”. Foreign Animal Disease Diagnostic Laboratory (FADDL) , Plum Island, USA.

3. Maintaining diagnostic capability for rinderpest virus”. The Pirbright Laboratory.

4. “Sequence and destroy: full genome sequencing of rinderpest virus isolates prior to their destruction”. (i) FADDL, (ii) The Pirbright Laboratory, (iii)CIRAD-BIOS.

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Process for approving FAO-OIE rinderpest holding facilities and research proposals