25 Years Innovating

A Journey through History of Retinol

Nobel Prize for discovering the Retinol structure.

1937

First clinical studies in Europe

1990

1990

First SKEYNDOR launch. Gel/Cream with Pure Retinol.

Primera fórmula SKEYNDOR con Retinol unido a la Vitamina C. VITAMIN C Eye Contour.

1998

First SK-RETINOL launch of multi-line with encapsulated or derived (palmitate) Pure Retinol 1300IU/g.

1999

Primera fórmula SKEYNDOR “retinoid-like” con “botox-like” + HA.

2004

Launch of SKEYNDOR ETERNAL with encapsulated Pure Retinol or derived (palmitate) 1300IU/g.

2009 2014

First SKEYNDOR formula with BAKUCHIOL (CORRECTIVE). Pioneering brand in Europe of introducing this formula for professional use.

2010

Launch of POWER RETINOL, 25th anniversary of this molecule in SKEYNDOR’S history with triple stabilised Pure Retinol 5000IU/g.

First SKEYNDOR Retinol formula with Vitamin C. VITAMIN C Eye Contour

First "Retinoid-like" SKEYNDOR formula with "botox-like" and HA

Plataforma Molecular

Increases the brand’s SCIENTIFIC EXPERTISE. Attracts new consumers who are more price sensitive. Easy communication. There are no barriers, no specific brands to transmit, favouring the whole distribution chain.

The POWER ranges combine together and complement other treatments.

Makes it possible to look for new targets and new uses.

Cosmetics by weight, according to concentration %.

Lines Segmentation

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+ P

rice

Technical Development

A new generation of Pure Retinol

RETINOIDS RETINOIDS have been used in beauty products since the 80s. Originally retinoids were applied in aesthetics medicine to treat problems caused by acne, and later it was discovered that retinoids have a very interesting regenerative anti-ageing effect. Since then retinoids application purpose was extended.

METABOLIC ACTIVITY OF RETINOIDS

Application Genetic and molecular level Functional and structural level Consumer level

Wrinkles/

Firmness

+Increase in collagen synthesis

- reduction of collagen degradation

+Reorganisation of collagen and

elastin in papillary dermis

-Reduced wrinkles and lines

+Improved firmness and

elasticity

Texture/

Thickness/

Acne

+Increase in epidermal GAGs +Increase epidermal proliferation

+Epidermis thickening

+Softened micro-relief

-Reduction of the skin’s rough

texture

Colour/Skin

tone

-Reduced tyrosinase activity

-Reduced tissue melanin -Inhibition melanosome transfer

-Reduced blemishes

+Uniform tone

Retinoids repair and rejuvenate the ECM (EXTRACELLULAR MATRIX)

VITAMIN A Vitamin A has three forms of oxidation: Retinol (alcohol), act as precursors of the acid. Retinal (aldehyde), act as precursors of the acid. Retinoic (acid). The unic biologically active. Retinoic acid has high cutaneous toxicity, therefore the skin tends to convert itself and store cell membranes in the form of retinol or its esters, which have a better toxicological profile and greater stability.

VITAMIN A The biological effectiveness of the different forms of Vitamin A is different according to the transformations that are needed to convert it into the active form. In order to be able to compare the retinoid activity of the products containing Vitamin derivatives, we use the IU (international activity units).

VITAMIN A IN COSMETICS In cosmetics the use of Vitamin A acid is forbidden due to its high toxicity, but its precursor forms are authorised, and the most usual one is the alcohol format (retinol). Even so, it has some limitations. According to the recommendations by the Scientific Committee on Consumer Safety (SCCS) and the World Health Organisation (WHO), it is not advisable to use 3000IU/g in regularly used cosmetics creams.

VITAMIN A IN COSMETICS It has clear advantages over its esters: Greater skin absorption; faster retinoic acid metabolism; clinically safe; similar toxicological profile; natural transformation into its esters by the epidermal cells. There are numerous clinical studies showing that :

Effective clinical dose: over 3000IU/g of retinol in cosmetic products have a visible anti-ageing effect after 8 weeks of treatment with 2 applications/day. Tolerated clinical dose: over 2000-2500IU/g it is possible to observe side effects (manifestation of retinoid effects) in certain individuals.

DECLARATION OF RETINOID EFFECTS

When the dose of retinoids exceeds the skin’s storage and control capacity, this triggers a complex skin appearance, known as retinoid erythema or manifestation of retinoid effects.

It appears during the first days of treatment and is characterised by dryness, scaling and finally, erythema and inflammation, and it can be extend continuously until the treatment with retinoids is removed.

PHOTOSENSITIVITY

Recent clinical studies (2013) reveal that retinoids are not photosensitive per se. The current tendency is to think that the photosensitivity of retinoids is caused by their effect on the skin –retinoid erythema- when used in inappropriate doses, and therefore it is not recommended to use these products while exposed to the sun’s rays, is maintained.

“RETINOID-LIKE” SUBSTANCES The “retinoid-like” substances are those which do not belong to the retinoid family but can behave like them in some aspects. Over the last 20 years, scientific cosmetics has focused on finding and studying “retinoid-like” substances which, unlike retinoids, have a better toxicological profile and improved molecular stability.

“RETINOID-LIKE” SUBSTANCES On a scientific and molecular level the great alternative in terms of a retinol substitute is bakuchiol, with a genetic expression profile almost identical to that of retinol, and it is stable and not photosensitive. On a commercial level other alternatives have appeared, mainly aqueous HS extracts –selected hydrosoluble substances- from leguminosea like Frigol makusta (Vigna acontifolia), Soy (Glycine Max) or Lucerne (Medicago Sativa),…. which have obtained cosmetic results similar to those obtained with the recommended cosmetic doses of retinoids (3000IU/gr).

POWER RETINOL is the result of in-depth research into retinoids and substances with retinoid or retinoid-like activity. Its mission is to rejuvenate aged skin by natural causes or by photo-ageing, sun.

SKEYNDOR launches a new formula to the market, based on the synergy of three active ingredients that are expertly combined to obtain a unique complex with surprising results. Three active ingredients have been carefully selected due to their distinctive rejuvenating activity, their unique ability to enhance each other synergically and producing a surprising anti-ageing result without side effects.

It is an extraordinary complex with great “retinoid” activity, made up of a

retinoid, Retinol, together with two “retinoid-like” substances,

Bakuchiol and the HS soy extract, which also boosts the repairing and rejuvenating activity of the retinol; one stabilises it and the other one reduces its side effects.

Pure retinol, an excellent rejuvenating element that can repair and recover the architecture and

qualities of young skin.

[ PURE RETINOL DERMAL REGENERATOR ]

The BAKUCHIOL molecule can act like retinol on a genetic stimulation level, and also it is a great retinol stabiliser, which

allows retinol-based products to be developed to maintain their effectiveness for longer.

Bakuchiol is an oil-soluble molecule that is extracted and purified from the leguminosae

Psoralea corylifolia.

MOLECULAR STABILISER ]

The HS soy extract, selected hydrosoluble extract (HS), on a functional level can produce a rejuvenating effect similar to that produced by retinoids, and with advantages that it can reduce the appearance of the manifestation of

retinoid effects and therefore reduce the side effects associated with retinoids.

[ HS SOY EXTRACT MINIMISES SIDE EFFECTS ]

ACTIVE

INGREDIENT ACTIVITY STABILITY SIDE EFFECTS

RETINOL Retinoid No Yes

BAKUCHIOL Retinoid –like Yes.

Stabilises retinol No

HS SOY EXTRACT Retinoid –like Yes

No

Reduces retinol side

effects

POWER RETINOL 3x Retinoid Yes No

TRIPLE REJUVENATING EFFECTIVENESS, MAXIMUM STABILITY, MINIMUM SIDE EFFECTS

Extraordinary SKEYNDOR formula with triple “retinoid” activity:

Product

Pure Concentrated Retinol 0.15%

5.000 IU

Organic Calendula Oil

Amber Extract Mask Intensive Antioxidant

Cream. SPF15

Treatment in institute INTENSIVE REPAIRING PROFESSIONAL PROGRAMME

PURE CONCENTRATED RETINOL Biological anti-ageing solution with pure concentrated retinol. Main components: Pure retinol 0.15% (5000 IU/g), Bakuchiol 1.0%, HS soy extract.

ORGANIC CALENDULA OIL Golden fluid with softening properties, and which helps to control the redness caused by retinoids. Rice in carotenoids (Vitamin A precursors). Main components: Pure Marigold oil (organic).

AMBER EXTRACT MASK Mask with amber extract, a fascinating material with antioxidant and conditioning properties, and able to preserve our skin’s beauty. Main components: Amber extract.

INTENSIVE ANTIOXIDANT CREAM A cream with a high concentration of antioxidant extracts and active ingredients, formulated to protect the substances sensitive to free radicals and also soften the signs of skin ageing. SPF 15. Main components: Antioxidant extracts (pomegranate, grape, Picea excelsa), Coenzyme Q10, Vit. C derivative.

Intensive repairing professional programme

1. Cleanse the skin around the eyes, and on the face, neck and cleavage with the SKEYNDOR make-up removal line most suited to the skin type. Tone and normalise the skin’s pH with the THERMAL CONCENTRATE WATER by AQUATHERM.

2. Remove the excess of dead cells with the Skeyndor Peeling. Wet your hands,

work with circular movements and remove with plenty of water. Reinforce the deep cleansing stage if necessary

with the EXFOLIANT CLEANSING GEL.

3. Start the intensive repair program. Apply about 4 ml of PURE CONCENTRATED RETINOL (4 to 5 sprays). Optionally, help the product penetrate the skin using the MESOSCIENCE equipment by SKEYNDOR, using the ELECTROPORATION current.

4 Next mix one part of the AMBER EXTRACT MASK with a few drops of

ORGANIC CALENDULA OIL, (3 drops for oily skins and about 8 drops for dry

skin). Massage face,, neck and cleavage, remodelling the whole face.

5. Apply the rest of the AMBER EXTRACT MASK over the face, neck and cleavage in a fine layer and leave for 15 minutes.

6. After this time has elapsed, smooth the skin and remove any excess product with damp sponges. Tone and finish the treatment with a small amount of INTENSIVE ANTIOXIDANT CREAM.

1 2

3 4

5 6

Home care INTENSIVE REPAIRING CREAM / EMULSION

* In vivo test (Clinical assessment, 64 volunteers, 8 weeks, x2applications/day, 0.1% Pure retinol)

• Rejuvenating activity on wrinkles and blemishes*. •Do not use more than two times a day. • Do not sun bathe without appropriate protection. • Safe cosmetic, minimum side effects.

ACTIVE INGREDIENTS • Pure retinol 0.06% (2000 IU/g). • Bakuchiol 0.75%. •HS soy extract.

It is available in two different textures according to the skin type: • Normal to dry skins: rich texture. • Mixed to oily skins: lighter, non-oily texture.

Available in a 50 ml. airless dosing tube.

Home care INTENSIVE REPAIRING SERUM-IN-CREAM • Rejuvenating action on wrinkles and blemishes*. • immediate perfecting effect for pigmentation. • Do not use more than two times a day. • Do not sun bathe without appropriate protection. • Safe cosmetic, minimum side effects.

ACTIVE INGREDIENTS • Pure retinol 0.09% (3000 IU/g). • Bakuchiol 1.0%. •HS soy extract.

Available in 30 ml. airless dosing tube.

* In vivo test (Clinical assessment, 64 volunteers, 8 weeks, x2applications/day, 0.1% Pure retinol)

WARNINGS for using RETINOL

•Do not use more than two times a day.

In the home treatment products, it is important not to exceed the total daily dose of 6000 IU: 2 applications/day Cream or Emulsion (3gx2000IU/g) 2 applications/day Serum-in-Cream (2gx3000IU/g) 1 application/day Serum + Cream or Emulsion (3000IU+2000IU) or the sporadic daily dose of 3000 IU: the Serum-in-Cream + Cream or Emulsion should not be used in the same application.

Results

Product recommendations

Line Recommendations and Skin Type

Line Main Target Effect

Skins with blemishes or lifeless skins

Brightens / Unifies

Skins with marks and/or photo-aged skins

Restores / Rebuilds

Mature and/or photo-aged skins

Re-pulps / Redensifies

Flaccid skins Reaffirms / Tightens

Skins with wrinkles

Smoothes / Corrects

Line Recommendations and Signs of Ageing

FLACCID SKIN

WRINKLES MARKS

BLEMISHES

FURROWS/ EXPRESSION

LINES

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Mature and /or

photo-aged skins

Young, photo-

aged skins

The Formula for Perfect Skin

RE C+ HA

+ Skins with blemishes and/or wrinkles

+ Fine and/or dehydrated skins

+ Lifeless and/or stressed skins

Skeyndor Face Creams

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+ PREMIUM SEGMENT

MEDIUM SEGMENT

AFFORDABLE SEGMENT

BEST VALUE FOR MONEY

Skeyndor Professional Treatment

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+

MEDIUM SEGMENT

PREMIUM SEGMENT

BEST VALUE FOR MONEY

Key Factors

Maximum concentration of PURE RETINOL 0.15% in one single professional session *. Cream and emulsion 0.06% and Serum-In-Cream 0.09%. Formula with great retinoid strength. Synergy of three ingredients with great rejuvenating power. Maximum cosmetic stabilization. Effecctive on wrinkles and blemishes**. Safe cosmetic, minimum side effects. The concentrations of retinol and other active substances, have been established by toxicology experts according to European recommendations. The formula is packaged in PE-AL airless multi-layer packages to guarantee the quality of the product.

Marketing Support

Professional Catalogue Includes Step by Step

Consumer Leaflet

Display Stand

Window or inside Display

Sachette Samples

Youtube Video Channel

Flickr Channel Images

POWER RETINOL

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