MD.MOHSIN

Rapid Mixer Granulator (RMG)

The Rapid Mixer Granulator is a

multi-purpose processor equally

suitable for high speed dispersion

of dry powders, aqueous or

solvent granulations and mixing

purposes.

Working principle:

Mixing and Wet Granulation

Process is performed in one

sequence.

The fast moving mixer blades

enforce the powder material in to

spiral fluidization at the bowl base.

Working principle contd.

This vortex effect in the material provides faster and

uniform (even) distribution of the ingredients.

This intensive mixing action distributes "active"

substances homogeneously within few minutes

By adding binder through charging hole at the top cover,

particles are uniformly moistened and aggregated to

large granules.

The vertically rotating, specially designed chopper

blades shears the circulating powder and breaks down

lumps and aggregates.

Thus granules attain higher density and uniformity in

shape, thereby achieving a uniform particle size

distribution.

The product is discharged by gravity within a few

Why used?

Excellent mixing and

consistent granules at lower

operating cost

Higher productivity.

Closed control of granule

size

Faster tableting speeds with

improved quality

Least rejections.

Fluidized bed dryer

The fluid bed principle is used to advantage in heating, cooling, carrying out chemical reactions, homogenising, and drying, but the success of these applications can only be realised when the solid sample is thoroughly mixed during the process.

Working principle:

Wet granules are placed at the detachable bowl and ispushed into the dryer

Fresh air passed through the pre filter and the gas areheated while passing through the heat exchanger

Hot air flows through the bottom of the bowl

Air velocity is gradually increased

Granules rise from the container then fall back,thiscondition is called fluidised state

Working principle contd.

Gas will surround the

granules for complete

drying

Air leaves the dryer by

passing through the bag

filter

Periodically bags are

shaken to remove the

entrained particle

Bowl is taken out for

discharging and the end

product is free flowing

Residence time for drying:

40 min

Why used?

Mostly used for drying of

granules

3 major functions: drying,

granulation & mixing

Also used for coating

purposes

Tablet Compression Machine

Compression is an important stage in tablet

manufacturing. There are mainly two ways to

compress tablet.

1.single punch

2.multiple punch/rotary press

Tablet Compression Machine is consist of

1. Hopper

2. Dies

3. Punches

4. Cam tracks

5. A feeding mechanism

Working principle

Why used?

To get the final product.

To get tablets in different

sizes and shapes.

Caplet Shape

Dies

Oval Shapes

Dies

Round Shapes Dies Star Shapes

Dies

Coating machine

Tablet coating is the

application of coating

composition to moving

bed of tablets with

concurrent use of heated

air to facilitate

evaporation of solvent.

Substances used for

coating are usually

applied as solution or

suspension under

conditions where vehicle

evaporates

Tablets are loaded into the machine at the beginning of

each batch.

They tumble on a rotating drum while a coating liquid

(solution, dispersion, or melt) sprays through nozzles

onto their surface.

Meanwhile, fans direct heated air through the tablets

and the perforated drum.

This air either evaporates the solvent or cools the melt.

The integrated plenum pans operate effectively at lower

airflows, which make them better suited for solvent

coating applications.

This process continues until the tablets are sufficiently

coated, at which point they are discharged from the

To mask unpleasant taste, odor

or color

To protect products from

environment, e.g. light, moisture,

oxygen

To reduce incompatibility

-To control drug release

- enteric coating

- sustained release coating

To promote aesthetic property

Avoid irritation of stomach

Reduce influence of moisture