Ch 19: Cardiovascular System

- The Heart -

•Give a detailed description of the superficial and internal anatomy of

the heart, including the pericardium, the myocardium, and the cardiac

muscle.

•Trace the path of blood through the heart.

•Explain the functioning of the valves of the heart and how they relate

to the heart sounds.

•Discuss the conductive pathway of the heart, and relate that to clinical

uses of the ECG.

Developed by

John Gallagher, MS, DVM

Circulation:: Overview

Size of a Fist

250 – 350 grams

Double Pump

Oxygenated and

deoxygenated blood

About 16,000 liters/day!

Pulmonary circuit

Systemic Circuit

Location of the Heart

Posterior to the

Sternum

Within the

Mediastinum

Apex vs. Base

sectional view: position immediately posterior to sternum . . .

Cardiac Muscle

Striated, aerobic,

interwoven, branched,

autorrhythmic

Intercalated discs - gap

junctions, strong

desmosomes

Functional syncytium

Fig 21.3

Cardiac Muscle Different from skeletal muscle?

Pericardium - Sac

1. Fibrous pericardium (AKA heart sac)- tough, collagenous

2. Serous parietal pericardium (lines fibrous pericardium)

3. Pericardial space with 10-20 ml of pericardial fluid

4. Serous visceral pericardium (AKA epicardium) adheres to the

outer heart surface

Structure of Heart Wall

Epicardium = visceral Pericardium (serosa)

Myocardium: muscle tissue + c.t. + blood vessels + nerves

Endocardium: simple squamous epithelium continuous

with endothelium of blood vessels

Pericardium

Pericardial fluid

Epicardium

Myocardium

Endocardium

Fibrous Skeleton

Internal c.t. network with lots of collagen and

elastic fibers

Encircles bases of great vessels

Encircles bases of valves

functions: Isolate atria from ventricles electrically

Reinforce myocardium itself

Surface Anatomy

Auricle of atria (expandable)

Coronary sulcus (between atria & ventricles)

Ant. & post. interventricular sulcus

Base (3rd costal cartilage) vs. apex (5th

intercostal space)

Vessels entering & leaving the heart

The Chambers

Separated by

– Interatrial Septum

– Interventricular Septum

– Externally, the septa appear as

shallow sulci

Right Atrium

– Receives blood from superior

and inferior venae cavae and the

coronary sinus

– Right auricle is prominent

externally

– Pectinate Muscles

The Chambers

Right Ventricle

– Receives blood from the right

atrium via the right AV valve,

AKA tricuspid valve

» Supported by chordae tendinae

and papillary muscles

– Thin wall

– Network of trabeculae carneae

The Chambers

Left Atrium

– Receives blood from R and L

Pulmonary Veins

Left Ventricle

– Receives blood from the Left AV

valve (AKA mitral AKA bicuspid)

» Chordae tendinae and papillary

muscles

– Thick wall

» Pumps to body via Aortic

Semilunar Valve

Sectional (Internal) Heart Anatomy

Atria & ventricles

Interatrial & interventricular septa

9981621

Valves (fibrous tissue)

Pectinate muscles (auricles & ant.

atria)

Trabeculae carneae (ventricles)

Chordae tendinae & papillary

muscles

Left vs. Right Ventricle

Left: high pressure pump

- Right: low pressure

pump right chamber is

thinner walled than left

Ventricles separated by

interventricular septum

Structure and Function of Valves

(prevent backflow)

= Mitral valve = Left AV valve

4 sets of valves

Each cusp is C.T.

covered with

endothelial cells

Close passively under blood pressure

Heart sounds produced by valve closure

picture taken from R ventricle, looking toward R atrium (see fig 21.6)

Support for AV valves:

Valves are

restrained by

chordae tendinae

which are in turn

attached to

papillary muscles

(prevention of

backflow!)

Fig 19.5 e

Mitral Valve Prolapse

Most common cardiac variation (5-10% of population)

Mitral valve cusps do not

close properly

Regurgitation during left

ventricular systole

Not life threatening; may be

lifestyle threatening

How can you diagnose?

Coronary Circulation

Coronary arteries: branch off the ascending aorta, immediately

distal to the aortic valve

coronary veins to coronary sinus to right atrium (inferior to

opening of inferior vena cava)

posterior view

Coronary Circulation, cont’d

Myocardial Infarction (MI)

~ 1.3 x 106 MIs / year in US

Most commonly due to severe CAD (coronary

thrombosis)

Ischemic tissue degenerates → nonfunctional area = infarct

Predisposing factors?

Cardiac Cycle

Actual physical contraction

pattern of the myocardium

as determined by the

conduction.

A. Contraction is systole

B. Relaxation is diastole

The two atria are in systole

and diastole together as are

the two ventricles.

Blood flow pattern through the heart

1. Blood enters right atrium via the superior and inferior venae cavae

2. Passes tricuspid valve into right ventricle

3. Leaves by passing pulmonary semilunar valves into pulmonary trunk and to the lungs to be oxygenated

4. Returns from the lung by way of pulmonary veins into the left atrium

5. From left atrium past bicuspid valve into left ventricle

6. Leaves left ventricle past aortic semilunar valves into aorta

7. Distributed to rest of the body

Auscultation of Heart Sounds:

# 1 (Lub): at beginning of ventricular contraction,

due to closure of the AV valves

# 2 (Dup): at beginning of ventricular diastole,

due to closure of the semilunar valves

Conducting System of the Heart p 570

Specialized muscle cells in the heart conduct APs to time and synchronize the action of the chambers

SA node – ”pacemaker,” spontaneously depolarizes most rapidly and initiate heart beat, positioned on back wall of right atrium , transmits action potential to the AV node.

AV node - (where the four chambers meet). Delay here.

AV bundle (bundle of His) transmits down top of interventricular septum where it divides into two.

Bundle branches, one of which supplies each ventricle where they branch into

Purkinje fibers reflect up external walls of ventricles and stimulate contraction of cardiac muscle cells as a unit.

Purkinje fibers extend into papillary muscles as well

Conducting System of the Heart

Specialized muscle cells in the heart conduct APs to time and synchronize the action of the chambers

SA node – ”pacemaker,” spontaneously depolarizes most rapidly and initiate heart beat, positioned on back wall of right atrium , transmits action potential to the AV node.

AV node - (where the four chambers meet). Delay here.

AV bundle (bundle of His) transmits down top of interventricular septum where it divides into two.

Bundle branches, one of which supplies each ventricle where they branch into

Purkinje fibers reflect up external walls of ventricles and stimulate contraction of cardiac muscle cells as a unit.

Purkinje fibers extend into papillary muscles as well

The EKG

P-wave

– Depolarization of atria

Delay at A-V node

QRS complex

– Depolarization of ventricles

T-wave

– Repolarization of ventricles

Autonomic Innervation of the Heart

Parasympathetic

– Vagus nerve (CN X)

Sympathetic

– Via sympathetic trunk