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pharmacology, hormonal therapy,
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Advance Pharmacology
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Mohanad AlBayati Mohanad AbdulSattar Ali Al-Bayati, BVM&S, MS. Physiology, PhD.
Assistant Professor of Pharmacology and ToxicologyDepartment of Physiology and Pharmacology
College of Veterinary MedicineUniversity of Baghdad Al-Ameria, Baghdad
Phone: 0964 7700766550E. Mail: [email protected]
Hormone
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Hormonal Homeostasis
Homeostasis
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Hormonal Class
Major Source Hormone Chemical Class
Mol
ecul
ar w
eigh
t30
kd
or le
ss
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Major Source Hormone Chemical Class
Hormonal Class
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Major Source Hormone Chemical Class
Hormonal Class
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Major Source Hormone Chemical Class
Hormonal Class
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Advance Pharmacology
Major Source Hormone Chemical Class
Hormonal Class
888
Advance Pharmacology
Major Source Hormone Chemical Class
Hormonal Class
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Advance Pharmacology
Endocrine and Hormone
Greek: Endocrine mean to separate within Hormone mean I excite
Non reproductive veterinary endocrinology• Recently, Increase awareness of the endocrine disorder • Endocrine disorders appear to be involved in about
10% - 20% of medical disease on small animals Largely been based on studies in large animal species
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Feedback Control of The Hypothalamic-Pituitary Axis
Advance Pharmacology
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Variation in Chemical Communication With an Animal
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Feedback control Hormonal Homeostasis
Advance Pharmacology
Endocrine system that a balanced state of feedback regulation be maintained among the various glands in order to maintain
Homeostasis
Direct and indirect Feedback control 1. Ultra short loop2. Short loop3. Long loopChemical Regulator1. Paracrain2. Neurocraine and neuroendocraine3. Endocraine 4. Paracraine5. Autocraine
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Ligands Working intracellular Messenger Pathways
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Ligands Working intracellular Messenger Pathways
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Ligands Working intracellular Messenger Pathways
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Receptors Working and Short comes
1. High affinity: strong tendency , Small number of hormone.2. High specificity: little tendency to bind other molecules 3. Low capacity: all receptor sites can be occupied (saturated)
low hormone concentration. i. Down regulation: ii. Prolonged hormonal exposure. Desensitized iii. Destroyed after endocytosis iv. Internalized and remain stored in intracellular vesicles v. Remain on the cell surface but bind hormone inappropriately vi. Receptor-Hormones complexes; induce sub-optimal response
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Cell receptors Cross-Communication and Drugs disorders
• Intracellular receptor ligand “Second messenger” communication • Inter-Receptor talker• Hormonal communication disorders
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Hypothalamic-Pituitary Hormones
Third ventricleOptic chiasmInfundibular stalkAnterior lobe Posterior lobeIntermediate lobe
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Hypothalamic-Pituitary Hormones
Advance Pharmacology
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Hypothalamic-Pituitary Hormones
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Hypothalamic-Pituitary Hormones and drugs interference
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proopiomelanocortin
Advance Pharmacology
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Growth hormone and drug interference
Advance Pharmacology
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Growth hormone and drug interference
Advance Pharmacology