Personalized medicine for ‡±—‹

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From the current treatment of chronic Hepatitis C to future personalized medicine

HLA-B*1502

003774 81-100015-00Translational MedicineThe process of turning appropriate biological discoveries into drugs and medical devices that can be used in the treatment of patients.003774 81-100015-00 Human MT1a MT1a Iridovirus viral load

Endoglin gene mutation Endoglin gene CYP2C19 003774 81-100015-00

HIV

HIV

MGMT methylation

MGMT Parvovirus B19 Parvovirus B19 003774 81-100015-00

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003774 81-100015-00Related KnowledgeBasic researchIntellectual PropertyFundingRegulatory AgenciesLegal IssuesEthical IssuesCommunication Skill

003774 81-100015-00Hippocrates used a persons physique and the seasons to personalize treatments for his patients. The modern scientific industry hopes to use your DNA.-- Pray,L.(2008)Personalized medicine: Hope or hype?Nature Education003774 81-100015-00

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003774 81-100015-00DRD2GRIN2AIGKC48003774 81-100015-00What Is Personalized Medicine?

Personalized medicine refers to the tailoring of medical treatment to the individual characteristics of each patient. It does not literally mean the creation of drugs or medical devices that are unique to a patient but rather the ability to classify individuals into subpopulations that differ in their susceptibility to a particular disease or their response to a specific treatment. 003774 81-100015-00What Is Personalized Medicine?Preventive or therapeutic interventions can then be concentrated on those who will benefit, sparing expense and side effects for those who will not.

--Presidents Council of Advisors on Science and Technology (PCAST) Priorities for Personalized MedicineSeptember 20081

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003774 81-100015-00The Treatment of Chronic Hepatitis B

003774 81-100015-00Hepatitis C Virus

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003774 81-100015-00Rapid Virologic ResponseEarly Virologic ResponseSustained Virologic Response003774 81-100015-00

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003774 81-100015-00Policy and Regulation003774 81-100015-00Legal and Ethical issuesGenetic Information Non-Discrimination Act (GINA), 2008. (2010 May).

003774 81-100015-00Human Leukocyte Antigen

003774 81-100015-00Nomanclature

003774 81-100015-00Example

003774 81-100015-00HLA-B*1502HLAMHCHLAMHC class IABCBHLA-BHLAHLA-BWHO HLA-B*1502HLA-B152

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003774 81-100015-00HLA-B*1502

CarbamazepineStevens-Johnson syndrome toxic epidermal necrolysisHLA-B*1502100%HLA-B*1502Carbamazepine

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003774 81-100015-00IVDClass I: Class II: Class III: +003774 81-100015-00

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003774 81-100015-00HLA-B*1502

carbamazepineICHLA-B*1502HLA-B*1502

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Real-time PCRin-house

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003774 81-100015-00Sequence of a pation

003774 81-100015-00HLA-B*1502 HLA-B*1502003774 81-100015-00