View
295
Download
0
Tags:
Embed Size (px)
Citation preview
Prediction of vertebral fracture by Trabecular Bone Score in elderly women of The Rotterdam Study
Atanasovska Biljana Department of Internal Medicine, Erasmus MC
Rotterdam, The Netherlands
Osteoporosedag der Hoge Landen
November 30th 2013
Mw. Drs. B
. Atanasovska
Authors Biljana Atanasovska, MSc1,2, Ling Oei, MD, MSc, MA1,2,3, Carolina Medina-Gomez, MSc1,2,3, Natalia Campos Obando, MD, MSc1,2,3, Karol Estrada, PhD1,2,3,4, Albert Hofman, MD, PhD2,3, Berengere Aubry-rozier, MD5, M. Carola Zillikens, MD, PhD1,3, André G. Uitterlinden, PhD1,2,3, Edwin H.G. Oei, MD, PhD6, Didier Hans, MBA, PhD5, Fernando Rivadeneira, MD, PhD1,2,3,.
1Department of Internal Medicine Erasmus MC Rotterdam, the Netherlands. 2Department of Epidemiology Erasmus MC Rotterdam, the Netherlands. 3Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), the Netherlands. 4Analytical & Translational Genetics Unit, Massachusetts General Hospital, USA. 5Lausanne University Hospital, Switzerland. 6Department of Radiology Erasmus MC Rotterdam, the Netherlands.
Disclosures: Didier Hans has a co-ownership of the TBS patent
The other co-authors have nothing to declare
Mw. Drs. B
. Atanasovska
Dual-energy X-ray absorptiometry (DXA) is commonly used to diagnose osteoporosis, providing accurate estimates of bone mass through the evaluation of bone mineral density (BMD)
BMD is not always an accurate predictor of fracture; it is an assessment of the quantity of bone but does not provide information on bone quality
Further, > 50% of fractures occur above the “osteoprosis” BMD threshold
Evaluating other bone parameters, such as bone microarchitecture, could significantly enhance the assessment of bone strength and fracture risk
BMD measured by DXA is an imperfect predictor of fracture risk, therefore, additional assessments are desirable
Mw. Drs. B
. Atanasovska
§ The trabecular bone score (TBS) is a measure of bone texture; correlates with 3D parameters of bone microarchitecture and a marker
for the risk of oteoporosis
Mw. Drs. B
. Atanasovska
§ TBS strongly correlated with the number and connectivity of trabeculae, while it is negatively correlated with the space between trabeculae
TBS ≤1.2 defines degraded microarchitecture TBS 1.20 - 1.35 is partially degraded microarchitecture TBS ≥1.35 is considered normal
After calibration
Mw. Drs. B
. Atanasovska
§ Trabecular bone score measurement
Hans at al., Journal of Clinical Densitometry 2011
- Identifying a method that differentiates these 2 types of structures will obtain a way to describe a 3-dimensional (3D) structures
Mw. Drs. B
. Atanasovska
Aim of this study
§ - examine the relation of trabecular bone score (TBS) with vertebral fracture in a population-based setting for:
§ 1) prevalent vertebral fractures assessed on radiographs (X-rays)
§ 2) incident clinical vertebral fractures (general practioner+hospital)
Mw. Drs. B
. Atanasovska
§ Rotterdam Study cohorts (RS-I, RS-II and RS-III) § N = 2760 women with DXA scans
§ DXA scans (GE-Lunar Prodigy; Madison, WI), LS-BMD and TBS measurement (TBS iNsight software – not calibrated) available in:
§ RS-I during the third follow-up
§ RS-II during the first follow-up
§ RS-III during the baseline visit
§ Women with BMI>35g/cm2 excluded
Study population
Mw. Drs. B
. Atanasovska
Study population
Clinical fracture follow-up
TBS X-ray
Mw. Drs. B
. Atanasovska
§ Incident clinical vertebral fractures occurring during follow-up: § RS-I and RS-II (combined n=1484, 21 cases)
§ HR from Cox-regression*
§ Radiographic vertebral fractures were available for :
§ RS-I-3 (McCloskey-Kanis; n=845, 53 cases)
§ RS-III-1 (Optasia quantitative morphometry; n=1272, 221 cases)
§ OR from Logistic- regression*
§ * Models corrected for age, height and weight
Mw. Drs. B
. Atanasovska
Results
- Both TBS and BMD mean levels are significantly lower in fracture cases than non-cases (P<0.05) - Correlation between TBS and LS-BMD was low (Pearson rho 0.25-0.30) across studies (P<0.001)
Population characteristics
Mw. Drs. B
. Atanasovska
§ Radiographic prevalent vertebral fractures were associated with increased risk per SD decrease in TBS score:
§ RS-I OR 1.71 95%CI [1.29-2.27]; P=0.0002
§ RS-III OR 1.27 95%CI [1.08-1.48]; P=0.004
§ Combined analysis of incident clinical vertebral fractures was suggestive of increased risk per SD decrease in TBS score:
§ RS-I+RS-II HR 1.48 95%CI [0.96-2.29]; P=0.08
§ Additional adjustment for lumbar spine BMD did NOT affect the risk estimates nor the interaction TBS x BMD
§ Lower TBS scores were associated with increased risk for prevalent and incident clinical vertebral fractures
Mw. Drs. B
. Atanasovska
TBS and LS-BMD together predict slightly better than LS-BMD alone
Prevalent vertebral fractures
Incident vertebral fractures
AUC CI
LS-‐BMD 0.685 0.655-‐0.716
TBS 0.686 0.655-‐0.717
LS-‐BMD+TBS 0.701 0.670-‐0.732
AUC CI
LS-‐BMD 0.664 0.560-‐0.767
TBS 0.692 0.584-‐0.800
LS-‐BMD+TBS 0.693 0.585-‐0.801
__ Reference __ Age, wgt, hgt __ + BMD __ + TBS __ + BMD & TBS
Mw. Drs. B
. Atanasovska
Conclusions
§ Trabecular bone score (TBS) is strongly & significantly associated with 1.3 to 1.7 increased risk for prevalent vertebral fractures per SD decrease
§ Each SD decrease in TBS is also associated (borderline significant) with 1.5 increased risk for clinical incident vertebral fractures
§ TBS associations with vertebral fractures are independent of DXA-based lumbar spine BMD and their combination slightly improves risk prediction
§ Subsequent studies with larger sample sizes are currently underway
Mw. Drs. B
. Atanasovska
Acknowledgments
Anis Abuseiris Jolande Verkroost Frank van Rooij
Marijn Verkerk Nano Suwarno Edward Peters Joost Verburg Jan Heeringa René Vermeeren
Mart Rentmeester Hans Bowier Hannie van den Boogert
Mette Offerhaus Florian Buisman Bart Hazemeijer Lisanne van de Koevering
Nuray Çakici Nienke Bart Rodinde Bloot Hanna Ning
Maarten Meijer Khadija Moumni Sander Verkade Sebastian Valk Bonila
Nadia Rbia Maria Tihaya Burak Kalin
Eugene McCloskey, Sheffield University, UK TBS inSIGHT: Research and Development section, Nuclear Medicine Division,
University of Geneva. Optasia: SpineAnalyzer® software §
Mw. Drs. B
. Atanasovska