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www.strandls.com
Overview of Strand Life Sciences
I. About Strand
II. Our Capabilities
III. Our Executive Team
IV. Our Partners
V. Our Strengths
About Strand
2000 -onwards Founded in 2000, 230+ employees
www.strandls.com www.strandls.com
About Strand
Founded in 2000, headquartered in Bangalore, India with US corporate headquarters in San Francisco
India’s first major academic spin-off has 230 employees; 50% computer science and 50% life science & clinical PhDs
Mature personalized medicine business in India
Leaders in genomic research software with 2,000 licenses worldwide and deep relationships with large corporations such as Agilent and L’Oreal
Bioinformatics at Strand
Several thousand
publications referring
these
www.strandls.com
Partners & Customers
Europe
North America
China & Japan
India
Australia
Atlas Clinic
Russia
www.strandls.com
Experience & Thought Leadership
VIJAY CHANDRU, PhD SCOTT STORRER, MBA RAMESH HARIHARAN, PhD KALYANASUNDARAM 'KAS' SUBRAMANIAN, PhD THIRU P. REDDY, MS
Co-founder, Chairman and Chief Executive Officer
• MIT (PhD), Purdue, IISc • Tech Pioneer – WEF • Fellow Indian Academy of
Sciences & Engineering
President, Strand Genomics
• Boston University • General Electric, CIGNA,
Cardinal Health, Genomind
Co-founder and Chief Technology Officer
• Courant(PhD), Max Plank, IISc , IIT –D
• MIT TR100
Chief Scientific Officer • Johns Hopkins (PhD),
IIT-B • Novartis, Entelos
Executive Vice President, Business Operations
• West Virginia • Bayer, Incyte
Talent from Premier Institutions & Universities
Board of Directors Advisory Board
VIJAY CHANDRU, PhD Co-founder, Chairman & CEO DAVID WETHERELL Managing Partner, Biomark Capital RAVI VENKATESAN Ex-Chairman, Microsoft India
RAMESH HARIHARAN, PhD Co-founder and CTO DOUGLAS LIND, MD Managing Director, Biomark Capital
CHARLES CANTOR, PhD CHARLES DeLISI, PhD SWAMI MANOHAR, PhD Co-founder V. VINAY, PhD Co- founder
ERIC EASTMAN, PhD KAL RAMNARAYAN, PhD D. BALA SUBRAMANIAN, PhD
www.strandls.com www.strandls.com
Our Clinical Platforms
• Personalized Medicine LDTs for Oncology & Inherited Diseases
• Strand SmartLab
• StrandOmics™ • A platform for
variant interpretation and reporting built for interpreters by interpreters
• GeneSpring®
• Strand® NGS • Gene expression
analysis software covering microarray and newer NGS technologies
Clinical Testing at Strand
Rare Inherited Disease
Germline Cancer Risk
Somatic Tumor Profiling
Cardiology
Ophthalmology
Tests ordered by clinicians from ~100+
hospitals
Off-the-shelf
panels
NGS Panels at Strand Today!
Strand –designed
panels
NGS Systems Illumina HiSeq 2500 MiSeq x3 Ion Torrent Ion Proton ABI SoLID AB3500 Sanger
ASSAYS Rigorous R&D High sensitivity NABL/CAP/CLIA
INTERPRETATION 55 Curators/Interpreters US Board certified Medical Geneticists Pathologists Genetic Counsellors
Clinical Operations: Bangalore
• >100 Hospitals and Clinics – Physicians ordering
tests • Central Reference Lab • Our Tests
– Gene Panels, Exomes
Access to one of the World’s largest patient pools
MILESTONES IN INDIA
Clinical Operations: Aurora, Colorado
BioScience Park at the Anschutz Medical Center
Preveen Ramamoorthy PhD VP Clinical Diagnostics Lab Director, Strand Genomics Inc.
Strand-Triesta Cancer Care Joint Venture (Strand/HCG) for cancer care using multi-gene tests.
• (51,000 new patients/year, 31 Hospitals in network)
– Standard of Cancer Care – Lung, Breast, Ovarian and
Colorectal Cancers – ~20,000 tests/year
Strand Translational Lab At Mazumdar-Shaw Medical Center
• Panel Designs • Cost Engineering
Biocon Research Centre
Major Partnerships in India
www.strandls.com www.strandls.com
Strand Innovation for Rapid Turn Around Time on Clinical Tests
Turnaround time as soon as in 7 days rather than weeks – comparable to single gene tests*
Graphics Processing Unit (GPU) based acceleration of data analysis to further improve TAT.
Automated laboratory and informatics workflows
Automation, data integration and manual data curation for interpretation and reporting
www.strandls.com
Strand® “Standard-of-Care” Report (part of StrandAdvantage test)
16
8 gene-report with quick turn-around-time (1 week)
Provides all the NCCN recommended gene tests for each cancer
Is bridged to the 48 gene and 161 gene test
No additional sample needed
Results in 2 weeks
161-gene Cancer panel Covers known oncogenes and tumor suppressor genes Genes that can help guide the choice of therapy options Predictors of response or resistance to targeted and chemotherapy drugs Markers for prognosis Those involved in drug metabolism
Turnaround time in days rather than weeks – comparable to single gene tests*
Strand SmartLab
Strand Core Platform Smartlab Experts
• Lab blueprint • Validated Panels and
Tests • LIMS+Sample tracking • Bioinformatics • Interpretation &
Reporting • Curation (45 scientists)
• Lab Director • Bioinformaticians • Genetic Counselors • Quality personnel • Clinical testing
personnel
Build, Operate and Transfer model to deliver a turnkey solution enabling laboratories and hospitals to develop in-house capabilities in NGS based diagnostics. Helps retain revenues and profits over time.
www.strandls.com
SmartLab Model
Differentiated offering: sets apart Strand as an end-to-end player – organically building on top of the PM Lab business
Fee for service contract or JV or hybrid models Build Operate and Transfer a fully functional CAP standard
laboratory equipped with Strand products and protocols.
Clinical interpretation / reporting is done by/at Strand
Target: Large hospital systems or Univs. or Dx/Path lab with expected volume of >5000 NGS panel tests per month
Strand products and interpretation services to SmartLab will earn ongoing revenues and royalties for us
Benefits of SmartLab to Community Hospitals
Bringing in lost revenue from referral tests.
More comprehensive test menu offering; Disruption of competition.
Improved Clinical Practice; Capacity Building; Localization due to regional variations in ethnicities; Better turnaround times with local processing; Sovereignty of bio-samples not compromised.
1. Capture revenue 2. Differentiated Lab 3. Value additions
www.strandls.com
Strand Strengths
Leaders in genomic software with over 2,000 licenses worldwide and growing
14-year-old company, financially strong and continually investing in innovation
Access to several hundred computer science, life science and clinical science PhDs
Unmatched capabilities in genomic software and personalized medicine
Harsha K. Rajasimha, PhD VP, Global Business Development
Strand Web Links
• Corporate Website: www.strandls.com •Strand Centers for genomics and personalized medicine: www.strandcenters.com • Strand genomics software products
• Strand-NGS: www.strand-ngs.com • StrandOmics: www.strandomics.com • GeneSpring GX: http://genespring-support.com
Follow us on Twitter @StrandLife, Facebook and Linkedin
Thank you!