Upload
kesho-conference
View
136
Download
0
Tags:
Embed Size (px)
Citation preview
Synthesis of Thienyl-appended Porphyrins for
Cancer TreatmentDr. Edith K. Amuhaya
Technical University of Kenya28/11/2014
Cancer StatisticsGlobal
Cancers among the leading causes of morbidity and mortality worldwide.
14 million new cases and 8.2 million cancer related deaths in 2012.
New cases expected to rise by about 70% by 2030.
Kenya
Third leading cause of death.
39,000 new cases annually
28,000 deaths annually
WHO, 2014 http://www.who.int/mediacentre/factsheets/fs297/en/Githanga, 2013
Cancer Treatment
http://www.jerryryanphd.com/biopage.html
http://www.tirgan.com/vp16.htm
http://medgadget.com/archives/2008/07/varians_rapidarc_radiation_delivery_system_goes_clinical.html
SURGERY
CHEMOTHERAPY
RADIATION THERAPY
3
Photodynamic Therapy (pdt)
PDT is a relatively new mode of treatment.
Components of PDT•Light of appropriate wavelength
•Oxygen
•Light sensitive drug (Photosensitizer)
Jablonski Diagram
http://www.discoverymedicine.com/Diana-M-Tacelosky/files/2012/04/discovery_medicine_no_71_brian_m_barth_figure_1.png
Drug Administration
• Administration of drug
• Incubation period
• Irradiation of tumor by light of desired wavelength.
http://belfield.cos.ucf.edu/pdt.html
Porphyrin-Based Photosensitizers
Synthesis of Dipyrromethane
Synthesis of thienyl-appended porphyrins
Synthesis of thienyl-appended porphyrins
Photophysical Studies
Biological Studies
Biological Studies
Future Work
Acknowledgements
• Technical University of Kenya
• Prof. M.G.H. Vicente (LSU, USA)
• Prof. Kevin M. Smith (LSU, USA)
• Dist. Prof. Tebello Nyokong’ (Rhodes University, SA)
• KESHO- Kenya