UNIVERSITY OF CALIFORNIA, SAN FRANCISCOGLADSTONE INSTITUTE OF VIROLOGY & IMMUNOLOGY

CENTER FOR AIDS RESEARCH

DIRECTORS’ INTRODUCTION

UCSF-GIVI CFAR Co-Directors

• Paul Volberding• Vice Chair and

Professor of Medicine UCSF

• Warner Greene• Director,

Gladstone Institute of Virology and Immunology

Both serve on the Executive Committee of the UCSF AIDS Research Institute

UCSF-GIVI CFARMission Statement

To nurture and sustain innovative multidisciplinary HIV research at the intersections of the basic, clinical, behavioral and epidemiologic scientific disciplines.

UCSF-GIVI CFARGoals and Objectives

• The careful weighing of all funding and programmatic decisions by the CFAR senior leadership team for their impact on the multidisciplinary research goal

• The establishment of six dynamic scientific cores that empower and encourage diverse groups of AIDS scientists and clinicians to work together effectively

• The creation of an active pilot project and mentoring program to ensure the full training of the next generation of HIV scientists and clinicians in multidisciplinary research

• The participation of the Center’s leadership in weekly meetings to achieve smooth and efficient operation of the Center, coupled with quarterly half-day strategic planning meetings to ensure that the Center responds proactively to new challenges and emerging opportunities in AIDS research

UCSF-GIVI CFARGoals and Objectives –

Continued• The institution of tight fiscal management

procedures that maximize the effective use of the Center’s resources

• The construction and maintenance of a high quality electronic network that connects and informs the entire CFAR membership of the Center

• The sponsorship of a seminar series and annual symposia that highlight advances through multidisciplinary research and encourage the involvement of new scientists in the activities of the Center

UCSF-GIVI CFAR Means Used to Achieve

Goals• Frequent and regular meetings of CFAR

leadership– Directors and managers (every 2 weeks)– Senior Leadership Group (every 2 weeks– CFAR Scientific Council (bi-monthly)

• A shared vision and commitment to interdisciplinary HIV investigation and the need to continually challenge and adjust priorities

UCSF-GIVI CFARGeography

• CFAR members and supported investigations are located at all sites of the University (and even draws on non-UCSF investigators as well)

• CFAR is active in establishing linkages to overcome these distances and to take advantage of them by sponsoring new collaborations

UCSF-GIVI CFAR Strategic Planning

• Continuous assessment of the relative strengths and weaknesses of the Center

• Looking back for “lessons learned” during the 16 year history of the Center

• Looking forward to ensure the Center Is positioned to respond to new challenges posed by the global HIV epidemic

• New UCSF-GIVI initiatives for 2003-2004(Funding,Mentoring and Science)

UCSF-GIVI CFAR Strengths

• Comprehensive HIV research program that has secured more than $70 million in annual funding

• Established, highly functional multi-disciplinary teams working at the interface of basic, clinical and behavioral HIV research

• Excellent scientific cores that “enable” HIV research throughout the community

• Availability of a large and willing patient base to address emerging research questions

UCSF-GIVI CFARWeaknesses

• Overall shortage of research space (to be partially corrected with the opening of Mission Bay

• Geographical dispersion of HIV investigators• The challenge of “stretching” limited CFAR

funding for meaningful impact within the large and diverse HIV research community

• No local primate center• Limited vaccine research program

DirectorsPaul Volberding, MD

Warner Greene, MD, PhD

CFAR Program Manager Sarah French Barrs, MBA

Associate DirectorsThomas Coates, PhD

Robert Grant, MD, MPH, MS Ruth Greenblatt, MD

Diane Havlir, MDJames Kahn, MD

Clinical CoreMark Jacobson, MD

Steven Deeks, MD Associate Director

Administrative CoreP Volberding, MD & W Greene, MD, PhDSarah French Barrs, Program Manager

Virology CoreRobert Grant, MD, MPH, MS

Teri Liegler, PhD, Associate Director

Immunology CoreJoseph M (Mike) McCune, MD, PhD

Barry Bredt, MA & Elizabeth Sinclair, PhD, Associate Directors

Specimen Bank CoreJohn Greenspan, BDS, PhD, FRCPathYvonne DeSouza, Associate Director

UCSF-GIVI AIDS/HIV INVESTIGATORS700+ Investigators & Research Staff located at six campus sites

and served by CFAR Cores, Activities, and Educational/Communications Services

UCSF-GIVI AIDS/HIV INVESTIGATORS700+ Investigators & Research Staff located at six campus sites

and served by CFAR Cores, Activities, and Educational/Communications Services

Developmental CoreP Volberding, MD & W Greene, MD, PhDSarah French Barrs, Program Manager

UCSF-GIVI CFAR SENIOR LEADERSHIP GROUP

CFAR SCIENTIFIC COUNCIL

Pharmacology CoreFrancesca Aweeka, PharmD

Population Sciences CoreJeffrey Martin, MD, MPH

Frederick Hecht, MD Associate Director

At-Large Members: David Bangsberg, MD, MPH, Carl Grunfeld, MD, PhD, Nancy Padian, PhD, B. Matija Peterlin, MD, Morris Schambelan, MD, Teresa Wright, MD

CFAR ADMINISTRATIVE/DEVELOPMENTAL STAFFCFAR ADMINISTRATIVE/DEVELOPMENTAL STAFF

Terry GleasonSr. Financial Analyst

Jennifer PlumbProgram Analyst

Philip CampbellProgram Associate

UCSF-GIVI CENTER FOR AIDS RESEARCH

2002-2003 Organizational Chart

UNIVERSITY OF CALIFORNIA, SAN FRANCISCOGLADSTONE INSTITUTE OF VIROLOGY & IMMUNOLOGY

CENTER FOR AIDS RESEARCH

CENTER OVERVIEW

UCSF-GIVI CFARTranslational Focus

• The critical importance of a clear and well articulated research mission

expanding the intersections of basic, clinical and behavioral/epidemiological HIV research

all CFAR planning, scientific, and financial decisions are made in the context of this multi-disciplinary research mission

UCSF-GIVI CFAR Strategic Focus

• Importance of proactive strategic planning within the Center

Half day CFAR strategic planning retreats are held every three months.

UCSF-GIVI CFARLeadership Focus

• Regular meetings of the CFAR Directors and Senior Leadership Group

Weekly Directors-Manager Meetings alternating with Senior Leadership Group Meetings

UCSF-GIVI CFARFiscal Focus

• Importance of centralized financial management

Added Mr. Terry Gleason as new Financial Analyst; providing cores with financial status reports monthly

UCSF-GIVI CFARMulti-disciplinary Focus

• Broad involvement of CFAR members in decision making

expansion of SLG to include Drs. Tom Coates, Ruth Greenblatt, and Diane Havlir

expansion of CFAR Scientific Council with addition of Drs. David Bangsberg, Carl Grunfeld, Nancy Padian, Matija Peterlin, Morrie Schambelan, and Teresa

Wright to help the Center respond to its Strategic Plan

UCSF-GIVI CFARLooking Forward

• Both short term (1 year) and longer term (5 year) strategic planning is conducted within the Center

• In December, 2001, a five year strategic plan for the Center was developed by an expanded group of CFAR members

• Half day, off-site strategic planning retreats attended by the Senior Leadership Group and invited guests are held quarterly.

UCSF-GIVI CFAR Local Initiatives

• Development of 3-5 Program Project Grant applications in the areas of HIV Latency, Hepatic-Metabolic Complications of HIV Infection, Pharmacology of HIV Therapy, HHV8 and Kaposi’s Sarcoma, and HIV/Alcohol/CNS Injury

• A preliminary application on HIV Latency has been submitted to the NIH and a Hepatic-Metabolic application is planned for 2003

• These PPG’s will take advantage of the CFAR Cores and will nucleate new multidisciplinary teams addressing current problems in HIV research

UCSF-GIVI CFAR Local Initiatives

• Expansion of developmental activities within the Center to include a new mentored scientist award, professional grant writing assistance for K-award and R01 applications, and implementation of a unique New Investigator “Start-up” Mentoring Program in collaboration with the Department of Medicine.

• Institution of a more proactive one on one mentoring program for junior faculty involving senior CFAR investigators

UCSF-GIVI CFAR National Initiatives

• Continuation and expansion of the highly successful C-NICS electronic database program with interested CFARs throughout the country

• Consideration of expansion of the C-NICS national model to specimen banking

UCSF-GIVI CFAR International Initiatives

• Expansion of the collaboration of the Center with Dr. Art Reingold and the Fogarty International Training Program

• Convene with Nancy Padian a University-wide roundtable to develop a coherent strategic plan for UCSF’s multiple international HIV research activities

• Support Diane Havlir’s new international clinical research initiative

• Develop a new program for participation of interested UCSF house-staff in international research activities

UNIVERSITY OF CALIFORNIA, SAN FRANCISCOGLADSTONE INSTITUTE OF VIROLOGY & IMMUNOLOGY

CENTER FOR AIDS RESEARCH

OVERVIEW OF CENTER CORES

UCSF-GIVI CFAR Cores

Administrative CoreDevelopmental Core

Clinical CorePopulation Sciences Core

Immunology CoreVirology Core

Specimen Bank CorePharmacology Core

UCSF-GIVI Center for AIDS Research

Administrative and Developmental Cores

CFAR Administrative & Developmental

Key Staff• Co-Directors

– Warner C. Greene, MD, PhD– Paul A. Volberding, MD

• Program Manager– Sarah French Barrs

• Administrative/Developmental Staff– Terry Gleason, Senior Financial Analyst– Jennifer Plumb, Program Analyst– Philip Campbell, Program Associate

CFAR Administrative CoreHighlights

• Program Project Grant initiatives• C-NICS Project• International Study Support• Directors’ Research Seminar Series• Annual Research Symposium• Tightening of Fiscal Control• Implementation of Videoconferencing

Meeting the Needs of UCSF-GIVI CFAR

Investigators• Routine meeting schedule

– Provides a regular and open forum for sharing ideas and directions

– Allows for new investigators and potential collaborators to meet and discuss future alliances

• Close evaluation of financial status– Allows rapid response to strategic

spending

CFAR Administrative CoreGeneral Operations

• Regularly scheduled meetings– Directors and Program Manager – twice

monthly– Senior Leadership Group – twice monthly– CFAR Scientific Council – six times per year– Strategic Planning – four times per year– External Advisory Review – annually

• CFAR space, resources, and institutional commitment review during strategic planning

CFAR Administrative CoreFinancial Operations

• Monthly reporting to Directors, Cores, Supplements, and Awardees

• Pre- and Post-Award Management• Evaluation of funding and spending

during strategic planning• Reallocation of unspent funding to

priority resources• Elimination/creation of cores as

needed

CFAR Administrative CoreEducational Operations

• Seminars– CFAR Directors’ Seminar Series– GIVI Seminar Series– CFAR-sponsored seminars

• Annual Research Symposium• Regular Center Communications

with CFAR members

CFAR Administrative CoreSupplement Support

• Pre- and post-award support for CFAR supplements• Financial and administrative oversight• Subcontract set up and maintenance• State Department approval for foreign components• Current Supplements Supported

– C-NICS– Fogarty/CFAR– HAART adherence in sero-discordant couples in

Zimbabwe

CFAR Developmental CoreProgram Summary

• Developmental awards have generated over $8.5million in subsequent funding

• Publications/Abstracts applicable to developmental awards in 2002/2003 = 16

• Programs and Services include:– Mentored Scientist Developmental Award Program– CFAR/Fogarty International Scientist Program– CFAR End of Year Supplements– Mentoring Initiative– Junior Investigator support/additional resources

CFAR Developmental Core Mentored Scientist

Program• Original program targeted junior

investigators and provided seed money– 2002/2003 – 2 awards – $50,000 total direct costs awarded

• Mentored program still targets junior investigators– All awardees must be paired with a mentor– Higher dollar cap on awards– 2002/2003 – 4 awards– $160,000 total direct costs awarded

CFAR Developmental CoreCFAR/Fogarty Collaboration

• CFAR awarded a supplement through UC Berkeley’s AITRP– Three years– $100,000 total costs per year– CFAR recompeted for this funding in 2003 to

obtain an additional 5 years of funding

• CFAR Foreign Scientist Training Program– 2002/2003 – 5 awards– $150,000 total costs awarded

CFAR International Awards• Novel approaches to preventing HIV transmission in high risk sex

workers in Cambodia ($24,955)• Training Adherence Measurement in Kampala, Uganda ($24,873

initial plus $42,500 continuation)• HIV Incidence in Brazilian blood Donors ($25,000)• Drug Resistance Epidemiology in Peru ($35,000)• Building Capacity for KSHV Research in Africa ($24,572)• HIV Prevention Research Training in Cambodia ($35,000)• Training in Surveys in Kampala, Uganda ($25,000)• AIDS Research Training in Zimbabwe ($25,000)• Makarere University AIDS Training Program ($26,865)• Post-Exposure Prophylaxis in S.African Rape Survivors (24,995)• Transmission of Kaposi's Sarcoma in Africa ($39,817)• HAART adherence in serodiscordant couples in Zimbabwe ($50,000)

CFAR Developmental CoreMentoring and Strategic

Initiatives• Junior Investigator Support

– CFAR Core investigator mentoring– Participation in institutional mentoring and

training activities– Grant writing support

• Strategic Investments– Core laboratory investments– Conference and Seminar Support– Student scholarships to educational events