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NanoMarket Worldwide Med 2013 Nano-655 Published October ts Report dical Ceramics Markets 2013 s

Worldwide Medical Ceramics Markets: 2013 Chapter One

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Page 1: Worldwide Medical Ceramics Markets: 2013  Chapter One

NanoMarkets Report

Worldwide Medical

2013

Nano-655

Published October 2013

NanoMarkets Report

Worldwide Medical Ceramics Markets

October 2013

Markets—

Page 2: Worldwide Medical Ceramics Markets: 2013  Chapter One

Worldwide Medical Ceramics MarketsWorldwide Medical Ceramics MarketsWorldwide Medical Ceramics MarketsWorldwide Medical Ceramics Markets

SUMMARYSUMMARYSUMMARYSUMMARY

NanoMarkets believes that medical ceramics represents a major opportunity in the

medical materials market over the next few years. They have already established

themselves in orthopedic and dental implants; providing a mul

problem-free bone and tooth replacements. Increasingly, prostheses for hip

replacement consist of metal ceramic composites. NanoMarkets also believes that

bioceramics and their metal composites have a great potential to heal long

segmental bone defects and that in

scaffold-guided bone tissue.

The primary goal of this report is to identify the market opportunities in the medical

ceramics sector over the next eight years. This report not only includes a granular

forecast and analysis of the more established medical ceramics markets, but also

gives a comprehensive analysis of medical nano

enhancing the healing properties of implantable materials.

This report discusses the commercial aspects o

ceramics and the numerous applications in which they can be used. The report also

profiles key suppliers and analyzes the complete supply chain for medical ceramics.

For the firms covered we discuss their strategies an

strengths and weaknesses.

Table of ContentsTable of ContentsTable of ContentsTable of Contents

Executive Summary Executive Summary Executive Summary Executive Summary

E.1 Opportunities for Medical Device and Implants Firms

E.2 Opportunities for the Healthcare Sector

E.3 Opportunities for Materials Firms

E.4 Firms to Watch in Medical

E.5 Summary of Eight-Year Forecasts of Medical Ceramics

Chapter One: IntroductionChapter One: IntroductionChapter One: IntroductionChapter One: Introduction

1.1 Background to this Report

1.2 Objective and Scope of this Report

1.3 Methodology of this Report

1.3.1 Forecasting Methodology

Worldwide Medical Ceramics MarketsWorldwide Medical Ceramics MarketsWorldwide Medical Ceramics MarketsWorldwide Medical Ceramics Markets————2013201320132013

NanoMarkets believes that medical ceramics represents a major opportunity in the

medical materials market over the next few years. They have already established

themselves in orthopedic and dental implants; providing a multitude of patients with

ree bone and tooth replacements. Increasingly, prostheses for hip

replacement consist of metal ceramic composites. NanoMarkets also believes that

bioceramics and their metal composites have a great potential to heal long

segmental bone defects and that in the future, orthopedic implants will rely on

The primary goal of this report is to identify the market opportunities in the medical

ceramics sector over the next eight years. This report not only includes a granular

and analysis of the more established medical ceramics markets, but also

gives a comprehensive analysis of medical nano-ceramics especially in terms of

enhancing the healing properties of implantable materials.

This report discusses the commercial aspects of all the current trends in medical

ceramics and the numerous applications in which they can be used. The report also

profiles key suppliers and analyzes the complete supply chain for medical ceramics.

For the firms covered we discuss their strategies and needs along with their

E.1 Opportunities for Medical Device and Implants Firms

E.2 Opportunities for the Healthcare Sector

E.3 Opportunities for Materials Firms

E.4 Firms to Watch in Medical Ceramics

Year Forecasts of Medical Ceramics

1.2 Objective and Scope of this Report

1.3 Methodology of this Report

1.3.1 Forecasting Methodology

Page | 1

NanoMarkets believes that medical ceramics represents a major opportunity in the

medical materials market over the next few years. They have already established

titude of patients with

ree bone and tooth replacements. Increasingly, prostheses for hip

replacement consist of metal ceramic composites. NanoMarkets also believes that

bioceramics and their metal composites have a great potential to heal long

the future, orthopedic implants will rely on

The primary goal of this report is to identify the market opportunities in the medical

ceramics sector over the next eight years. This report not only includes a granular

and analysis of the more established medical ceramics markets, but also

ceramics especially in terms of

f all the current trends in medical

ceramics and the numerous applications in which they can be used. The report also

profiles key suppliers and analyzes the complete supply chain for medical ceramics.

d needs along with their

Page 3: Worldwide Medical Ceramics Markets: 2013  Chapter One

1.3.2 Plan of Report

Chapter Two: Chapter Two: Chapter Two: Chapter Two: Medical Ceramics: Current Use and Major Technology TrendsMedical Ceramics: Current Use and Major Technology TrendsMedical Ceramics: Current Use and Major Technology TrendsMedical Ceramics: Current Use and Major Technology Trends

2.1 Ceramic Composites: Key Medical

2.1.1 Ceramic Compositions and Processes

2.1.2 New Production Methods Increase Application of Medical Ceramics

2.1.3 Ceramic Injection Molding

Implants

2.2 Bioactive ceramic coatings

2.2.1 Calcium Phosphate Coatings

2.2.2 Hydroxyapatite coatings

2.2.3 Glass ceramic coatings

2.2.4 Diamond-Like Carbon Coatings

2.3 Alumina and Zirconia Ceramics

2.4 Future Advances with Piezo

2.5 Current and Future Applications of Medical Nano

2.6 Predominantly Glass and Partially Filled Glass Ceramics

2.7 Key Points Made in this Chapter

Chapter Three: Applications Markets for Medical Ceramics Chapter Three: Applications Markets for Medical Ceramics Chapter Three: Applications Markets for Medical Ceramics Chapter Three: Applications Markets for Medical Ceramics

3.1 Major Factors Impacting the Medical Ceramics Market

3.1.1 Clinical Trials

3.1.2 Environmental Regulations

3.1.3 Intellectual Property Issues

3.1.4 Globalization and Trade Barriers

3.1.5 Research and Development

3.2 Medical Ceramics in Orthopedics

3.2.1 Total Hip and Joint Replacements

Medical Ceramics: Current Use and Major Technology TrendsMedical Ceramics: Current Use and Major Technology TrendsMedical Ceramics: Current Use and Major Technology TrendsMedical Ceramics: Current Use and Major Technology Trends

2.1 Ceramic Composites: Key Medical-Related Trends

2.1.1 Ceramic Compositions and Processes

2.1.2 New Production Methods Increase Application of Medical Ceramics

2.1.3 Ceramic Injection Molding Produces Small High Precision and Intricate

2.2 Bioactive ceramic coatings

2.2.1 Calcium Phosphate Coatings

Like Carbon Coatings

2.3 Alumina and Zirconia Ceramics

Advances with Piezo-ceramics and Sensors

2.5 Current and Future Applications of Medical Nano-Ceramics

2.6 Predominantly Glass and Partially Filled Glass Ceramics

2.7 Key Points Made in this Chapter

Chapter Three: Applications Markets for Medical Ceramics Chapter Three: Applications Markets for Medical Ceramics Chapter Three: Applications Markets for Medical Ceramics Chapter Three: Applications Markets for Medical Ceramics

3.1 Major Factors Impacting the Medical Ceramics Market

3.1.2 Environmental Regulations

3.1.3 Intellectual Property Issues

3.1.4 Globalization and Trade Barriers

3.1.5 Research and Development

3.2 Medical Ceramics in Orthopedics

1 Total Hip and Joint Replacements

Page | 2

Medical Ceramics: Current Use and Major Technology TrendsMedical Ceramics: Current Use and Major Technology TrendsMedical Ceramics: Current Use and Major Technology TrendsMedical Ceramics: Current Use and Major Technology Trends

Produces Small High Precision and Intricate

Page 4: Worldwide Medical Ceramics Markets: 2013  Chapter One

3.2.2 Ceramic composites as Artificial Joint Systems and Bioglass Implantable

Components

3.2.3 Regeneration of Bone Tissue Using Scaffold

3.2.4 Other Orthopedics Applications

3.2.5 Eight-Year Forecast of Medical Ceramics in Orthopedics, by Material and

Medical Procedure

3.2.6 Notable Companies and Other Organizations Influencing the Use of Ceramics

in Orthopedics

3.3 Medical Ceramics in Dentistry

3.3.1 Main Applications for Medical Ceramics in

3.3.2 Eight-Year Forecast of Medical Ceramics in Dentistry by Material and Dental

Procedure

3.3.3 Notable Companies and Other Organizations Influencing the Use of Ceramics

in Dentistry

3.4 Medical Ceramics in Medical Equipment

3.4.1 Surgical Equipment

3.4.2 Diagnostic Equipment

3.4.3 Ceramics in Implantable Electronic Devices

3.4.4 Eight-Year Forecast of Medical Equipment, by Material and Equipment Type

3.4.5 Notable Companies and Other Organizations Influencing the Use of Ceramics

in Medical Equipment

3.5 Injectable Ceramic and Ceramic Composites for In Vivo Regeneration of Hard

and Soft tissues

3.5.1 Eight-Year Forecast of Medical Ceramics in Regeneration Procedures

3.5.2 Notable Companies and Other Organizations Influencing the Use of Ceramics

in Regeneration Procedures

Chapter Four: Summary of Forecasts and Geographical AnalysisChapter Four: Summary of Forecasts and Geographical AnalysisChapter Four: Summary of Forecasts and Geographical AnalysisChapter Four: Summary of Forecasts and Geographical Analysis

4.1 Summary of Eight-Year Market Forecasts

4.1.1 Summary by Procedure

4.1.2 Summary by Type of Equipment/Implant

3.2.2 Ceramic composites as Artificial Joint Systems and Bioglass Implantable

3.2.3 Regeneration of Bone Tissue Using Scaffold-Guided Tissue Engineering

3.2.4 Other Orthopedics Applications

ecast of Medical Ceramics in Orthopedics, by Material and

3.2.6 Notable Companies and Other Organizations Influencing the Use of Ceramics

3.3 Medical Ceramics in Dentistry

3.3.1 Main Applications for Medical Ceramics in Dentistry

Year Forecast of Medical Ceramics in Dentistry by Material and Dental

3.3.3 Notable Companies and Other Organizations Influencing the Use of Ceramics

3.4 Medical Ceramics in Medical Equipment

3.4.3 Ceramics in Implantable Electronic Devices

Year Forecast of Medical Equipment, by Material and Equipment Type

3.4.5 Notable Companies and Other Organizations Influencing the Use of Ceramics

3.5 Injectable Ceramic and Ceramic Composites for In Vivo Regeneration of Hard

Year Forecast of Medical Ceramics in Regeneration Procedures

3.5.2 Notable Companies and Other Organizations Influencing the Use of Ceramics

Chapter Four: Summary of Forecasts and Geographical AnalysisChapter Four: Summary of Forecasts and Geographical AnalysisChapter Four: Summary of Forecasts and Geographical AnalysisChapter Four: Summary of Forecasts and Geographical Analysis

Year Market Forecasts

4.1.2 Summary by Type of Equipment/Implant

Page | 3

3.2.2 Ceramic composites as Artificial Joint Systems and Bioglass Implantable

Guided Tissue Engineering

ecast of Medical Ceramics in Orthopedics, by Material and

3.2.6 Notable Companies and Other Organizations Influencing the Use of Ceramics

Year Forecast of Medical Ceramics in Dentistry by Material and Dental

3.3.3 Notable Companies and Other Organizations Influencing the Use of Ceramics

Year Forecast of Medical Equipment, by Material and Equipment Type

3.4.5 Notable Companies and Other Organizations Influencing the Use of Ceramics

3.5 Injectable Ceramic and Ceramic Composites for In Vivo Regeneration of Hard

3.5.2 Notable Companies and Other Organizations Influencing the Use of Ceramics

Page 5: Worldwide Medical Ceramics Markets: 2013  Chapter One

4.1.3 Summary by Type of Medical Ceramic Material

4.2 Markets for Medical Ceramics in the U

4.2.1 Regulatory Environment

4.2.2 Trends and Opportunities

4.3 Eight-Year Forecasts of Markets for Medical Ceramics in Europe

4.3 Markets for Medical Ceramics in Europe

4.3.1 Regulatory Environment

4.3.2 Trends and Opportunities

4.3.3 Eight-Year Forecasts of Markets for Medical Ceramics in Europe

4.4 Markets for Medical Ceramics in Japan

4.4.1 Regulatory Environment

4.4.2 Trends and Opportunities

4.4.3 Eight-Year Forecasts of Markets for Medical Ceramics in Japan

4.5 Markets for Medical Ceramics in China

4.5.1 Regulatory Environment

4.5.2 Trends and Opportunities

4.5.3 Eight-Year Forecasts of Markets for Medical Ceramics in China

4.6 Other Notable National and Regional Markets for Medical Ceramics

4.6.1 Eight-Year Forecasts of Markets for Medical Ceramics in Other Parts of the

World

RELATED REPORTSRELATED REPORTSRELATED REPORTSRELATED REPORTS

Worldwide Medical Polymer Markets: 2013Worldwide Medical Polymer Markets: 2013Worldwide Medical Polymer Markets: 2013Worldwide Medical Polymer Markets: 2013

4.1.3 Summary by Type of Medical Ceramic Material

rkets for Medical Ceramics in the U.S.

4.2.2 Trends and Opportunities

Year Forecasts of Markets for Medical Ceramics in Europe

4.3 Markets for Medical Ceramics in Europe

pportunities

Year Forecasts of Markets for Medical Ceramics in Europe

4.4 Markets for Medical Ceramics in Japan

4.4.2 Trends and Opportunities

Year Forecasts of Markets for Medical Ceramics in Japan

Markets for Medical Ceramics in China

4.5.2 Trends and Opportunities

Year Forecasts of Markets for Medical Ceramics in China

4.6 Other Notable National and Regional Markets for Medical Ceramics

casts of Markets for Medical Ceramics in Other Parts of the

Worldwide Medical Polymer Markets: 2013Worldwide Medical Polymer Markets: 2013Worldwide Medical Polymer Markets: 2013Worldwide Medical Polymer Markets: 2013----2020202020202020

Page | 4

casts of Markets for Medical Ceramics in Other Parts of the

Page 6: Worldwide Medical Ceramics Markets: 2013  Chapter One

Chapter One: Introduction

1.1 Background to this Report

1.1.1 Two Principal Sectors

In the past, medical ceramics were represented by ceramic and clay implants

in the host and acted as scaffolds or supports.

to the introduction of an entirely new generation of bioceramics. These implants

structurally and functionally compatible

development of new tissue. Over the past two decades

in the performance of these bioceramics,

for ceramics in the medical sector.

The two key markets for medical ceramics

• Implantable bioceramics

market as tooth and bone replacements. Bone and joint replacements are essentially

metal and ceramic composites, where

systems. Bioceramics are a huge success as implantable materials

bioactive in their natural compositions and can be fabricated into various composites

metals, both natural and synthetic

nanotubes.

• Medical equipment

primarily used in analytical,

Although there are a few risks and ambiguities

based on ceramics, NanoMarkets

will continue to grow in

businesses by the companies

supply the necessary raw materials.

1.1.2 Implantable Bioceramics Market Dominated Replacements

Biocompatibility and resistance to wear have made ceramic materials ideal for a range of medical

applications, from artificial joints to electronic sensors, stimulators

Alumina and zirconia, among other ceramics, have been successful in

environment of the human body.

segments: tooth and bone replacements.

Dental implants: The dental consumables segment includes crown

orthodontics, impressive materials, composites, endodontics, adhesives

dental equipment segment is composed of large equipment

chairs, communication systems, compressors, cuspidors

equipment, including amalgam removal system

equipment, duplicators, and ultrasonic cleaners, also fall into

Introduction

Background to this Report

Two Principal Sectors of the Medical Ceramics Market

medical ceramics were represented by ceramic and clay implants that

as scaffolds or supports. Today the scenario has changed remarkably

an entirely new generation of bioceramics. These implants

structurally and functionally compatible with living tissue in the human body and

. Over the past two decades, there has been tremendous improvement

in the performance of these bioceramics, and technology advances have created a huge market

for ceramics in the medical sector.

for medical ceramics are:

e bioceramics, which consist of medical devices and implants

market as tooth and bone replacements. Bone and joint replacements are essentially

al and ceramic composites, whereas dental implants are mostly made of all

oceramics are a huge success as implantable materials

bioactive in their natural compositions and can be fabricated into various composites

metals, both natural and synthetic polymers, carbon fibers, and most

Medical equipment, including analytical and scientific instrumentation

in analytical, diagnostic, vision, and therapy systems.

Although there are a few risks and ambiguities regarding the use of implants an

NanoMarkets certainly believes that the market for implantable bioceramics

the future. This growth can possibly be converted into profitable

the companies manufacturing the medical ceramic devices and the firms

raw materials.

1.1.2 Implantable Bioceramics Market Dominated by Tooth Replacements

Biocompatibility and resistance to wear have made ceramic materials ideal for a range of medical

applications, from artificial joints to electronic sensors, stimulators, and drug delivery devices.

Alumina and zirconia, among other ceramics, have been successful in withstanding

environment of the human body. The implantable bioceramics market primarily consists of two

segments: tooth and bone replacements.

dental consumables segment includes crowns/bridge

orthodontics, impressive materials, composites, endodontics, adhesives, and cement

uipment segment is composed of large equipment, such as autoclaves, sterilizers,

chairs, communication systems, compressors, cuspidors, and digital imaging system

equipment, including amalgam removal systems, amalgamators, hand piece cleaner

and ultrasonic cleaners, also fall into this product segment.

Page | 5

that remained inert

e scenario has changed remarkably due

an entirely new generation of bioceramics. These implants are, amazingly,

and contribute to the

there has been tremendous improvement

and technology advances have created a huge market

consist of medical devices and implants that are on the

market as tooth and bone replacements. Bone and joint replacements are essentially

as dental implants are mostly made of all-ceramic

oceramics are a huge success as implantable materials because they are

bioactive in their natural compositions and can be fabricated into various composites with

most recently, carbon

analytical and scientific instrumentation; ceramics are

implants and medical devices

certainly believes that the market for implantable bioceramics

converted into profitable

ceramic devices and the firms that

y Tooth and Bone

Biocompatibility and resistance to wear have made ceramic materials ideal for a range of medical

and drug delivery devices.

withstanding the hostile

et primarily consists of two

/bridges, implants,

and cements, while the

autoclaves, sterilizers,

and digital imaging systems. Small

, amalgamators, hand piece cleaners, lab

product segment.

Page 7: Worldwide Medical Ceramics Markets: 2013  Chapter One

The leading multinational manufacturers account for approximately two thirds of the global implant

market and pursue premium strategies. The remainder of the market is ve

consisting of several hundred competitors, the majority of which have a local country or regional

focus.

The competition in the global dental implant market is intense

including Nobel Biocare, Straumann, Dent

market include low dental implant penetration rates and

population. Another factor

increase in life expectancy results in

increasing urban population

Bone implants: Alumina and zirconia

due to their mechanical strength and chemical inertness.

one of the globally renowned medical ceramic manufacturers that has substantial experience

developing clinically proven ceramic joints using alumina

MTC’s Vitox AMC alumina matrix composite bioceramic material

shown to have exceptionally low wear rates compared with alternative materials.

dependable solution that does not have the

and it is longer lasting, thus

Medical-grade silicon nitride ceramics

arthroplasty segments.

Ceramics are also used in bone tissue engineering

biocompatible properties. Scaffolds that typically act as engineered bone grafts can be used in

several specialty applications

1.1.3 Wide Use o

Ceramics are widely used

systems, medical test equipment

piezoceramic objective focusing device

DNA research. Piezoceramics have become the

manufacturers for the execution of accurate positioning and precise movements.

Because the number of people

bioceramics and composites continue

biomedical equipment depends on the number of

utility. Thus, NanoMarkets believes that the demand for implantable bioceramics materials will be

higher than that for ceramic

1.1.4 Market Opportunities

Dental consumables represent the largest segment of the dental care industry

equipment. In other words,

are in great demand and account for most of the market

during implantation account

The leading multinational manufacturers account for approximately two thirds of the global implant

market and pursue premium strategies. The remainder of the market is ve

consisting of several hundred competitors, the majority of which have a local country or regional

The competition in the global dental implant market is intense, with only a

Nobel Biocare, Straumann, Dentsply, and Zimmer. The main drivers of the global dental

market include low dental implant penetration rates and an increasing worldwide elderly

that drives the dental market is longer life expectanc

e expectancy results in a more elderly population. Increasing consumer income

increasing urban populations are other major factors that are boosting the dental market.

Alumina and zirconia are the main ceramic materials for bone implan

their mechanical strength and chemical inertness. Morgan Technical Ceramics (MTC)

one of the globally renowned medical ceramic manufacturers that has substantial experience

clinically proven ceramic joints using alumina and zirconia.

Vitox AMC alumina matrix composite bioceramic material used in hip joints

have exceptionally low wear rates compared with alternative materials.

that does not have the potential health risks associated with metal hip joints,

thus enabling patients to continue to lead active lifestyles.

grade silicon nitride ceramics have good potential to find applicability in

used in bone tissue engineering because of their osteoinductive and

Scaffolds that typically act as engineered bone grafts can be used in

several specialty applications, such as bone regeneration and wound healing.

of Ceramics In Biomedical Equipment

Ceramics are widely used in biomedical equipment, such as ultrasound machines,

medical test equipment, and imaging instruments. MTC has, for example,

jective focusing device that provides the millisecond responsiveness essential for

DNA research. Piezoceramics have become the premium choice for medical device

manufacturers for the execution of accurate positioning and precise movements.

er of people that need implants is always on the rise, demand for

bioceramics and composites continues to increase, while the number of ceramic parts used in

biomedical equipment depends on the number of pieces of equipment manufactured and the

believes that the demand for implantable bioceramics materials will be

higher than that for ceramic components used in medical equipment.

1.1.4 Market Opportunities for Implantable Bioceramics Materials

esent the largest segment of the dental care industry,

, implantable bioceramics consisting of tooth and bone replacements

are in great demand and account for most of the market, while the tools and instruments

implantation account for just a small part of the overall market.

Page | 6

The leading multinational manufacturers account for approximately two thirds of the global implant

market and pursue premium strategies. The remainder of the market is very fragmented,

consisting of several hundred competitors, the majority of which have a local country or regional

only a few large players,

and Zimmer. The main drivers of the global dental

increasing worldwide elderly

drives the dental market is longer life expectancies, because an

more elderly population. Increasing consumer incomes and

the dental market.

ceramic materials for bone implants, largely

Morgan Technical Ceramics (MTC) is

one of the globally renowned medical ceramic manufacturers that has substantial experience in

hip joints has been

have exceptionally low wear rates compared with alternative materials. It is therefore a

ealth risks associated with metal hip joints,

enabling patients to continue to lead active lifestyles.

good potential to find applicability in the spinal and

their osteoinductive and

Scaffolds that typically act as engineered bone grafts can be used in

ultrasound machines, point-of-care

, for example, launched its

millisecond responsiveness essential for

choice for medical device

manufacturers for the execution of accurate positioning and precise movements.

demand for implantable

the number of ceramic parts used in

manufactured and their

believes that the demand for implantable bioceramics materials will be

Implantable Bioceramics Materials

, followed by dental

ooth and bone replacements

tools and instruments used

Page 8: Worldwide Medical Ceramics Markets: 2013  Chapter One

The scenario described above

global population is growing and likely to continue to grow, but also the magnitude

steadily increasing. Due to this

the bioceramics materials market to

In this growing market, bioceramics materials suppliers will have

generate new business revenues from

manufacturing technologies

significant contributors to clinical success will be mat

and reduce manufacturing costs.

The implant manufacturing giants like Nobel Biocare, Strauman

solutions to patients that receive

scans to the actual devices

and implant-based) were produced

(CAD/CAM) in 2012. Although the majority of prosthetic element

share of dentists using CAD

1.1.5 Nanoceramic Composites

Ceramic materials fabricated in the form of nano

regeneration applications. I

forming cells called osteoblasts have proliferated on substrates with nanoceramic particles and

coatings.

However, when the ceramics are formed into composites with

cytotoxicity has been observed in some experiments.

composites with amine and amide groups may lead to the accumulation of toxic debris that can

evoke inflammatory and/or immune responses and ultima

composite when implanted in a human host. Moreover, the rejection of the implant sometimes can

lead to sepsis or septic shock.

Therefore, while nanoceramic composites have potential in the future as implants and medical

devices, NanoMarkets believes that key

properties must first be addressed before that potential can be realized.

Major implant manufacturers

appropriate clinical trials before implant

released to the market.

In addition, NanoMarkets has observed that the number of companies offering

growing. Therefore, firms

significant advantages, will only be able to

advantage, because most clinicians are price sensitive, the

lower-cost substitute implants.

1.2 Objectives and Scope

This report is the latest NanoMarkets

The scenario described above suggests that not only the number of small implants used by the

growing and likely to continue to grow, but also the magnitude

Due to this steady growth in the small implants market, NanoMarkets expects

the bioceramics materials market to continue to grow over the next eight years.

In this growing market, bioceramics materials suppliers will have expanded opportunities to

generate new business revenues from both natural substrates and composites and novel

manufacturing technologies, such as injection molding and electro-spinning.

significant contributors to clinical success will be materials that are bioactive,

and reduce manufacturing costs.

The implant manufacturing giants like Nobel Biocare, Strauman, and Zimmer

that receive bone and joint replacements, from computed tomograph

s. More than 20 percent of all of the prosthetic elements (tooth

) were produced using computer-aided design/computer-aided manufacturing

in 2012. Although the majority of prosthetic elements are still made by hand, the

share of dentists using CAD/CAM prosthetic elements continues to increase.

eramic Composites: Promising But Risky

Ceramic materials fabricated in the form of nano-sized particles show promise in bone tissue

In fact, many in vitro studies have proved beyond a

forming cells called osteoblasts have proliferated on substrates with nanoceramic particles and

However, when the ceramics are formed into composites with carbon nanotubes (CNTs),

cytotoxicity has been observed in some experiments. In addition, nanoceramic polymer

composites with amine and amide groups may lead to the accumulation of toxic debris that can

evoke inflammatory and/or immune responses and ultimately lead to the rejection of the

composite when implanted in a human host. Moreover, the rejection of the implant sometimes can

lead to sepsis or septic shock.

nanoceramic composites have potential in the future as implants and medical

NanoMarkets believes that key questions about their biocompatibility and bioactive

first be addressed before that potential can be realized.

ers must conduct thorough research studies and,

ppropriate clinical trials before implants and prostheses containing nanoceramic composites

In addition, NanoMarkets has observed that the number of companies offering

firms that simply offer acceptable clinical solutions,

, will only be able to compete on price. However, if they can offer a price

most clinicians are price sensitive, the clinicians may gravitate to the newer

substitute implants.

1.2 Objectives and Scope of This Report

NanoMarkets report on opportunities in the medical ceramics markets.

Page | 7

that not only the number of small implants used by the

growing and likely to continue to grow, but also the magnitude of sales are

in the small implants market, NanoMarkets expects

expanded opportunities to

composites and novel

spinning. However, the

, improve lifetimes,

and Zimmer offer end-to-end

s, from computed tomography (CT)

prosthetic elements (tooth-based

aided manufacturing

s are still made by hand, the

sized particles show promise in bone tissue

a doubt that bone-

forming cells called osteoblasts have proliferated on substrates with nanoceramic particles and

carbon nanotubes (CNTs),

anoceramic polymer

composites with amine and amide groups may lead to the accumulation of toxic debris that can

tely lead to the rejection of the

composite when implanted in a human host. Moreover, the rejection of the implant sometimes can

nanoceramic composites have potential in the future as implants and medical

questions about their biocompatibility and bioactive

more importantly,

s containing nanoceramic composites are

In addition, NanoMarkets has observed that the number of companies offering nanoceramics is

acceptable clinical solutions, and not clinically

However, if they can offer a price

may gravitate to the newer

report on opportunities in the medical ceramics markets.

Page 9: Worldwide Medical Ceramics Markets: 2013  Chapter One

NanoMarkets has been providing

markets for several years, and

emerging opportunities in the field. Th

prospects for bioceramic materials and implants in the coming eight years.

We have extensively studied

analyzed what we perceive

in both implantable bioceramics and ceramics. The

forecasts both in revenue and

ceramics, as well as the latest substrates and composites

1.3 Information Sources

NanoMarkets has conducted industry research

and this report is written on the basis of ongoing discussions with key p

industry. In addition, a cumulative analysis of the

weaknesses of the major players

Additional information for this report was drawn from the Internet, commercial databases, trade

press articles, press releases, industry reports and market updates, and corpora

order to further understand the activity that is taking place in th

In addition, this report is entirely international in scope. We have conducted interviews worldwide

in order to collect information

focusing on any specific geographic areas.

The medical ceramics market forecasts

both material shipments and manufacturing capacities. We also consider the success rates of the

implants and estimate the needs of major medical ceramics producers with respect to their

materials suppliers. The materials forecasts are broken down by ma

and fabrication process. The forecasting methods followed and

the forecasts in this report are explained in more detail in

1.4 Plan of This Report

Chapter Two discusses the major

bioceramics. An explanation

should occur in the market in order

analysis forms the basis for

Chapter Three examines the

influencing the medical ceramics

property (IP), acquisitions, and consolidation. In this chapter, we analyze the R&D strategies of

some of the major players in this space

ceramics, and scaffold-guided

We also provide a comprehensive account of

influencing the use of ceramics in

present our detailed eight

medical instrumentation. The forecasts are organized primarily by application and functionality

providing comprehensive industry analysis of the medical ceramics

for several years, and this report presents information on the existing markets and

in the field. Thus, the goal of this report is to analyze and forecast the

prospects for bioceramic materials and implants in the coming eight years.

ied the market dynamics in the medical ceramics materials sector and

what we perceive to be the different opportunities that are emerging for materials

in both implantable bioceramics and ceramics. These opportunities are summarized in

revenue and volume terms for all of the predominantly used materials in medical

ceramics, as well as the latest substrates and composites.

Information Sources and Methodology for This Report

s conducted industry research on medical ceramics and bioceramic materials,

and this report is written on the basis of ongoing discussions with key players throughout the

cumulative analysis of the industry, including the strengths

weaknesses of the major players, was considered when writing this report.

for this report was drawn from the Internet, commercial databases, trade

press articles, press releases, industry reports and market updates, and corpora

order to further understand the activity that is taking place in the medical ceramics market space.

his report is entirely international in scope. We have conducted interviews worldwide

in order to collect information for the report and arrived at the worldwide forecasts

geographic areas.

market forecasts presented in this report are drawn from our

both material shipments and manufacturing capacities. We also consider the success rates of the

implants and estimate the needs of major medical ceramics producers with respect to their

materials suppliers. The materials forecasts are broken down by material type and functionality

and fabrication process. The forecasting methods followed and assumptions used

the forecasts in this report are explained in more detail in Chapter Four.

the major ceramics technologies and the various current

bioceramics. An explanation of the existing market status with a few insights into the changes that

occur in the market in order to make it more dynamic and profitable is also provided

for our forecasts, which are presented later in Chapter Four of the report.

Chapter Three examines the applications for medical ceramics and reviews the m

eramics market with a focus on recent developments in

, acquisitions, and consolidation. In this chapter, we analyze the R&D strategies of

some of the major players in this space with respect to ceramics for use in implants,

guided bone tissue engineering on bioceramic scaffolds.

a comprehensive account of notable companies and o

eramics in implants, regenerative medicine, and medical equipment

ight-year forecasts of implantable bioceramics and ceramics

The forecasts are organized primarily by application and functionality

Page | 8

comprehensive industry analysis of the medical ceramics

the existing markets and

goal of this report is to analyze and forecast the

the medical ceramics materials sector and

the different opportunities that are emerging for materials used

are summarized in detailed

terms for all of the predominantly used materials in medical

medical ceramics and bioceramic materials,

layers throughout the

including the strengths and

for this report was drawn from the Internet, commercial databases, trade-

press articles, press releases, industry reports and market updates, and corporate literature in

medical ceramics market space.

his report is entirely international in scope. We have conducted interviews worldwide

arrived at the worldwide forecasts without

presented in this report are drawn from our estimates of

both material shipments and manufacturing capacities. We also consider the success rates of the

implants and estimate the needs of major medical ceramics producers with respect to their

terial type and functionality

assumptions used when preparing

current applications for

the existing market status with a few insights into the changes that

is also provided. This

later in Chapter Four of the report.

reviews the major factors

nt developments in intellectual

, acquisitions, and consolidation. In this chapter, we analyze the R&D strategies of

with respect to ceramics for use in implants, injectable

bone tissue engineering on bioceramic scaffolds.

other organizations

and medical equipment and

of implantable bioceramics and ceramics used in

The forecasts are organized primarily by application and functionality.

Page 10: Worldwide Medical Ceramics Markets: 2013  Chapter One

In Chapter Four, we provide

based on application, functionality, and type of material, with considerable focus on

processing and fabrication technologies.

geographies, including the U

In Chapter Four, we provide summary eight-year forecasts of the bioceramics materials secto

application, functionality, and type of material, with considerable focus on

processing and fabrication technologies. We also present our eight-year forecasts for key

geographies, including the U.S., Europe, Japan, China, and the rest of the world.

Page | 9

forecasts of the bioceramics materials sector

application, functionality, and type of material, with considerable focus on the

year forecasts for key

world.