FocusFactories:TheAdvantagesoftheSpecializedApproach-CityofHopeHarlanLevineChiefExecu2ve,CityofHopeMedicalFounda2on

FocusFactoryCaseStudy:COHHematopoie?cCellTransplant(HCT)Program

•  Flagshipprogramfounded41yearsago•  Performedmorethan13,000marrowand

bloodstemcelltransplants–  SecondlargestHCTprograminUnitedStates(650/

year)

•  Volumeandfocusleadto:–  RapidintegraLonofphaseIclinicaltrialandnovel

therapeuLcsintotransplantregimens–  Data-driven,mulL-stakeholderqualityprogram

drivesconLnuousprocessimprovement–  OnlyHCTprogramintheUnitedStatestoachieve

survivaloutcomesaboverisk-adjustedexpectedsurvivalfor11consecu?veyears

CIBMTRAnalysisof1-yearSurvivalforAllogeneicTransplanta<on

1: -1 indicates under-performing; 1 indicates over-performing; 0 indicates performing as predicted. 2: 2012 includes unrelated and related HCTs performed in 2008-2010; 2013 includes unrelated and related HCTs performed 2009-2011; 2014 includes unrelated and related HCTs performed 2010-2012.

IntheU.S.,onlyCityofHopehasperformedaboveexpecta?onfor11consecu?verepor?ngyears

•  CenterforInternaLonalBlood&MarrowResearchreleaseddatashowinghematopoieLcstemcelltransplantsurvivaloutcomes(mostrecentresultspublished12/15)

•  Ourratesforone-yearsurvivalwereamongthebest

–  Predictedone-yearsurvival:67.7%(95%CI:64.6-71.0)/Actualone-yearsurvival:75.2

PerformancebyReportYear1,2

Center CenterName 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015

60 ShandsHealthCare&UniversityofFlorida 1 0 0 0 0 0 -1 0 0 1 1

61 UniversityofIowaHospital&Clinics 0 -1 0 0 0 0 -1 0 0 1 1

63 JohnsHopkinsOncologyCenter 0 0 0 0 0 1 1 1 0 0

65 ClevelandClinic 0 0 0 0 0 0 0 0 0 -1 0

68 UniversityofPiVsburghMedicalCenter 0 0 0 0 0 -1 0 0 0 0 0

69 UniversityofWisconsinHospital&Clinics -1 0 0 1 1 0 0 0 0 0 0

70 Froedert&MedicalCollegeofWisconsin 0 -1 -1 -1 -1 0 0 0 0 1 1

73 WayneStateUniversityHospital(Karmanos) 0 -1 -1 0 0 0 1 1 1 0 0

74 AllChildren'sHospital 0 0 0 -1 -1 -1 0 0 0 0 0

76 Children'sHospitalofLosAngeles 0 0 0 0 0 0 0 -1 -1 0 0

78 DanaFarberCancerIns<tute-Adults 1 0 1 1 1 1 0 0 0 1 1

79 UniversityofCalifornia-SanFrancisco-Pediatrics 0 0 0 0 0 0 1 1 0 0 0

80 VanderbiltUniversity 0 0 0 0 0 0 0 1 1 1

81 CityofHopeNa<onalMedicalCenter 1 1 1 1 1 1 1 1 1 1 1