Genetic Influences on Robustness of Weaned Pigs

Birth Weight Sets The Stage

• Lower viability at birth

• Greater pre-weaning mortality

• Lower weaning weights

• More culls• Lower ADG• Fewer full value pigs

Continued Selection for Total Born

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-2.5

-2

-1.5

-1

-0.5

0

0.5

120

0601

2006

0620

0611

2007

0420

0709

2008

0220

0807

2008

1220

0905

2009

1020

1003

2010

0820

1101

2011

0620

1111

2012

0420

1209

2013

0220

1307

2013

1220

1405

2014

1020

1503

2015

08

Selecting for profitability

Maternal Lines Only All Lines*

Total Born Scrotal Hernia Lifetime Growth

Number of Stillborns Umbilical Hernia Backfat

Preweaning Mortality Cryptorchid Loin Depth

Birth Weight Wean-to-Finish Mortality Leg Score

Weaning Weight Semen Quality Feed Intake

Wean-to-Estrus interval Primal Values

Teat Number pH

Lactate*

IMF*

G/F Survival & Robustness Reproduction

Efficient Growth Carcass Traits

Terminal Lines

Selecting for Profit

PIC’s breeding program is focused to drive towards total value across multiple traits

Maternal Lines

PIC improves total born & pre-wean survivability

61. Relationship based genomic selectionSource: PIC L02, L03 pure lines (Camborough)

Introduction of RBGS1

-3%

-2%

-1%

0%

1%

2%

3%

4%

(2.5)

(2.0)

(1.5)

(1.0)

(0.5)

-

0.5

200601 200701 200801 200901 201001 201101 201201 201301 201401 201501 201601

Pre-wean survivability(% of born alive)

(relative to '13-'15 avg)

Total born (pigs/sow/yr)

(relative to '13-'15 avg)

Birth year / month

Trend: genetic improvement in pre-wean survivability and total born(PIC Genetic Nucleus)

Total Born

Prewean Survival

PIC improves total born & birth weight

71. Relationship based genomic selectionSource: PIC L02, L03 pure lines (Camborough)

Introduction of RBGS1

-0.06

-0.04

-0.02

0

0.02

0.04

0.06

0.08

(2.5)

(2.0)

(1.5)

(1.0)

(0.5)

-

0.5

200601 200701 200801 200901 201001 201101 201201 201301 201401 201501 201601

Birth weight(kg/pig)

(relative to '13-'15 avg)

Total born (pigs/sow/yr)

(relative to '13-'15 avg)

Birth year / month

Trend: genetic improvement in birth weight and total born(PIC Genetic Nucleus)

Total Born

Birth Weight

PIC Genetic PlatformFull utilization of genomic

science

• Scope, scale, experience…

• Today, ~100,000 animals/year• Deep genomic pedigrees• Every nucleus male is genotyped• Every animal around the world is positively impacted• Every trait we select for on every animals is impacted

How genomic selection works

Sire

Child 1 Child 2 Child 3 Child 4

Child 5 Child 6

In theory you can have sibs that are genetically unrelated

This is why I am different from my brother

0

20

0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1Additive genetic relation

HSFSm=4

And “hidden” relationships

5 Years of PIC Genetic Trend

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50

60

70

80

90

100

110

120

130

140

15020

1104

2011

0820

1112

2012

0420

1208

2012

1220

1304

2013

0820

1312

2014

0420

1408

2014

1220

1504

2015

0820

1512

2016

04

Maternal

Terminal

Genomic Implementation

The Next Wave of Innovation

Genome Sequencing

• Impact• Greater selection accuracy• Causal variants• Capture de-novo mutations• Molecular biology targets

• Timeline• Roslin project• 3 years

Accelerating Genetic GainWhat’s Next?

Without PRRS….

• Healthier, more robust litters and individual

piglets

• Improved pre-weaning mortality

• Better downstream growing pig performance

and feed efficiency

• Reduces disease interaction

Gene editing

GE is the process of precise editing genome

Nucleotides can be

• added

• deleted

• replaced

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PRRS ResistanceHigh Level Overview

• Pigs were created with minor nucleotide edits within their existing DNA

• No new or foreign DNA was inserted into the pigs

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Accelerating Progress

PIC Full Program

1 Year Avg

Index 19.5

Pigs weaned/sow/year 1.1

Pounds weaned/sow/year 17.7

Pigs marketed/sow/year 1.0

Total Pounds marketed/sow/year 410.7

PROFIT PER PIG 3.89

Summary

• We continue to improve the pig at a faster pace

than ever before

• Breakthrough technologies will further

accelerate the pace

• Execution will be the key to success