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Glutamine methylation in Histone H2A is an RNA Polymerase I dedicated modification
Peter Tessarz1, Helena Santos-Rosa1, Sam C. Robson1, Kathrine B. Sylvestersen2,Christopher J Nelson1,3, Michael L. Nielsen2, and Tony Kouzarides1,*
Speaker : Indra Lasmana Tarigan (英德拉 )Advisor : Prof. Chien-Chia Wang (王健家教授 )
Seminar of Department Life Sciences, National Central University
Introduction
Modification Histone
Scheme Epigenetic Mechanism
Methylation in Lysine
(Heinrich, et.al, 2014)
Result
Identification and localization of methylated H2A glutamine 105
Identification of Nop1/Fibrillarian as the methyltransferase of Q105
b
C
Genomic landscape of Q105me
Genomic landscape of Q105me
Unmodified Q105 is part of a recognition motif for FACT
Unmodified Q105 is part of a recognition motif for FACT
Discussion
Thank you for your attention
Replication through Nucleosomes
Immunofluorescence Microscopy
Coomassie Brilliant Blue
CFU