Step Closer to Custom-Building New Blood Vessels

•The group of researchers used Induced pluripotent stem

cells, commonly abbreviated iPSCs, are a type

of pluripotent stem cell artificially derived from a non-

pluripotent cell by inducing a "forced" expression of

specific genes. Usually used as target an adult cell

differentiated (cell differentiation) from a tissue on which is

induces the expression of several foreign genes. IPS cells

are able to differentiate into cells of tissues from the three

germ layers of a human embryogenesis.

Mathematical Models Target Disease With Drugs Chosen by Your DNA

•Pharmacogenomics is the technology that analyses how

genetic makeup affects an individual's response to drugs.

It deals with the influence of genetic variation on drug

response in patients by correlating gene expression with a

drug's efficacy or toxicity. By doing so,

pharmacogenomics aims to develop rational means to

optimize drug therapy, with respect to the patients'

genotype, to ensure maximum efficacy with minimal

adverse effects.

As you can read in the article, even from the title, the construction of a capillary network from pluripotent

stem cells and synthetic material (hydrogel infusion), is a process that is not ready, tested and safe for humans,

yet. It is clear that I have not checked other experiments in this area of investigation; so I have no

points of comparison to say how advanced is this research. At least, they started experimenting with

animals and seems to have good results; I hope that they continue, to find significant results applicable to humans. Something that can be an advantage in this

research is the use of new processes of growth, like, start from induced pluripotent stem cells, and selection of specifics stem cells to the needs of the investigation.

Information on pharmacological

targets

The framework characterizes a medicament's

Absorption

Distribution

Elimination properties

Yielding

Physiological pathways and,

disease systems in patients

Resulting in predictions of treatment effectiveness.

This is the beginning of a truly personalized medicine, at least as far as medicaments are concerned, since thanks to the collection of

statistical data and pharmacological studies, is being achieved eliminate the margin of error

that could have a treatment, to suit the needs specific of patients according to their genetic

material, thus fulfilling, in practice, with de phrase: "no hay enfermedades sino enfermos".

Personally I find a great step in medicine, so that is closer to be an exact science.

The general application of this research is the ability to rebuild a microvascular

bed in a clinically relevant manner, they have made an important step toward

the construction of blood vessels for therapeutic use more effective

treatments for patients afflicted with burns, diabetic complications and other conditions in which vasculature function

is compromised.  

One particularity in this case was the used of technics that made the process quicker, and the

use induced pluripotent stem cells as their starting point. Since this type of cell is made by reverse-engineering mature cells -- from the skin or blood, for example -- using it means that the resulting blood vessels could be tailor-made for

specific patients.

The goal of this research is a future with more effective medications,

faster healing and fewer side effects, and to achieve it, they studied at

how an individual person responds to an individual drug by deriving and using sophisticated mathematical

models, such as differential equations. The team's equations also including information about how the body processes a drug and how the

drug acts in the body.

The researchers created a statistical analysis framework of differential

equations that they expect will help doctors and pharmacists, by

simulating such variables as protein-protein and protein-DNA interactions

a drug has in a patient, it will facilitate the quantitative prediction

of the responses of individual subjects as well as the design of

optimal drug treatments, by determine what drug and dose might be best for that person.

· Johns Hopkins Medicine (2013, July 16). Step closer to custom-building new blood vessels. ScienceDaily, [online]. Retrieved July 19, 2013, from http://www.sciencedaily.com-/releases/2013/07/130716161844.htm;  [consulta: 16 de julio de 2013].

· Penn State (2013, July 16). Mathematical models target disease with drugs chosen by your DNA. ScienceDaily, [online]. . Retrieved July 19, 2013, from http://www.sciencedaily.com-/releases/2013/07/130716120030.htm; [consulta: 16 de julio de 2013].