I want to publish more and read less

I need to publish more and read less

Cameron Neylon - Munin ConferenceTromsø - 22 November 2011

Wednesday, 14 December 11

http://www.flickr.com/photos/cappellmeister/39508741 CC-BY

technologies...


http://www.flickr.com/photos/cappellmeister/39508741


conceptual changes...

http://www.flickr.com/photos/ivanwalsh/4509575889 CC-BYWednesday, 14 December 11

http://www.flickr.com/photos/ivanwalsh/4509575889


...central principle.

http://www.flickr.com/photos/mkumm/2709555496 CC-BY


http://www.flickr.com/photos/mkumm/2709555496


But first.


Helen BermanLorie LeJeune

Iain Emsley

Neil Saunders

Brian Kelly

Harry Collins

Michael Nielsen

Jen Dodd

Greg Wilson

Timo Hannay

Maxine Clarke

Jenny RohnRicardo Vidal Paulo Nuin

Jenny HalePeter Murray-Rust

Deepak Singh

Jon Udell

Tim O’Reilly

David Crotty

Rafael Sidi

Richard Akerman

Jean-Claude Bradley

Mike Ellis

Liz Lyons

Andy Powell

Gavin Baker Peter Suber

Victor Henning

Sabine HossenfelderFlickr

Google

Steve Wilson

Andrew Milsted

Frank Norman

Dave de RoureJeremy Frey

John Cumbers

Bill Flanagan

ISIS LSS Group

Lakshmi Shastry

Catherine Jones

ISIS Computing GroupSTFC

Plausible AccuracyJohn

Dupuis

Chad Orzel

Ken Shankland

Martyn Bull

Jonathan Gray

Rufus Pollock

Clay Shirky

Kevin Kelly

Gavin Bell

Shirley Wu

Euan Adie

Richard Curry Ian Mulvany

Jamie McQuay

Atilla Csordas

Pawel Szcsesny Gabriel Cavalli

Matt Wood

TIM HUBBARD

DUNCAN HULL

Richard Grant Branwen Hide

PLoS

Friendfeed

Bora Zivkovic

Peter Binfield

John Wilbanks

Kaitlin ThaneyThe BioGang

Tony WilliamsEgon Willighagen

Martin FennerYaroslav Nikolaev

Jon EisenMichael Eisen

Richard Akerman

Jeremiah FaithMichael Barton

Lee Smolin

Garret Lisi

Victoria Stodden

Simon ColesTony Hey

Noel Gorelick

Jon Tansley

Benjamin Good Dorothea Salo

Paul Walk

Mitch Waldrop

Björn Brembs

Rich Apodaca

Bill Hooker

Pedro Beltrao

Mat Todd

SciFoo 2008/9

campers

Stephen Brenner

Brian Matthews

Allyson Lister

Phil Lord

Steve Koch

Koch Lab

Carole Goble

Stephen FriendEva Amsen

JOHN WILLINSKY

TIM HUBBARDTIM HUBBARDTIM HUBBARD

Steph Hannon

Rebecca Goulding

Leigh Dodds

Paul Miller

Mark BorkumDan Hagon

Jim Downing

Nico Adams

@gnatFabiana Kubke

Hope LemanLisa Green

Ariel Waldmann

@tGrace Baynes

Simon Philips

Matt Johnson

Lee Dirks

Microsoft

NPG Ben Goldacre

Arfon Smith

Nicholas Cole

Chris Leonard

PIERRE LINDENBAUM

ALAN CANN

Jo Badge

Mummi Thorissson

Andrew Kasarskis

Glyn Moody

@communicating

PT Sefton

Andrew Farke




Who am I?


http://www.flickr.com/photos/andypowe11/3915450391

I live in Bath




I work at RAL


Wikimedia Commons Succinate_Dehydrogenase_1YQ3_and_Membrane.png

Wikimedia CommonsMGMT BDNA_1T38.png

I work on...


http://commons.wikimedia.org/wiki/File:Succinate_Dehydrogenase_1YQ3_and_Membrane.png




I work on...


I work on...


http://www.flickr.com/photos/59937401@N07/5929622407 CC-BY

I write grants...


http://www.flickr.com/photos/59937401@N07/5929622407


http://flickr.com/photos/nicmcphee/2756494307/ CC-BY

...and papers...


http://flickr.com/photos/nicmcphee/2756494307/

http://flickr.com/photos/nicmcphee/2756494307/


Slideshare - http://slideshare.net/CameronNeylon/presentations

39 Presentations~100,000 views


http://sciencecard.org/CameronNeylon?page=1


http://cameronneylon.net




Papers are not enough...


...software...


...data...


Need to communicate...


http://www.flickr.com/photos/jurvetson/3184362622 CC-BY

all the pieces...


http://www.flickr.com/photos/jurvetson/3184362622


Need to maximise “impact”...

http://www.flickr.com/photos/babasteve/3140688308 CC-BYWednesday, 14 December 11

http://www.flickr.com/photos/babasteve/3140688308


But that’s ok...


We have new tools...

http://www.flickr.com/photos/kylemay/1430449350 CC-BY


http://www.flickr.com/photos/kylemay/1430449350

http://www.flickr.com/photos/kylemay/1430449350

Many new ways and places to publish...


So...


group, and finally attachment to the solid support. In addition theuse of intein based methods as well as the preparation of the solidsupport for Staudinger ligation often require reagents such asphosphines or thiophenols that are toxic and difficult to handle.Therefore there remains a significant need for robust and simple

methodologies for protein immobilization that can be applied towide range of proteins and solid supports. The identification of theSortase transpeptidase [19] provided an alternative approach toprotein ligation. Sortases recognise a specific peptide sequence(LPETG for SrtA of S. aureus used in this work) in proteins targetedfor covalent attachment to the cell wall peptidoglycan. The peptidetag sequence is cleaved and then ligated to the pentaglycine moietyon the peptidoglycan precursor Lipid II. Proteins expressed with theC-terminal recognition sequence can be covalently attached to a widerange of constructs with an N-terminal glycine amidemotif includingpeptides [20], PNA [21], full length proteins [22] and small moleculesubstrates [23]. Another group has independently described anexample of Sortase mediated ligation to a beaded solid support [22].These reactions proceed under aqueous conditions without theaddition of any further reagents beyond the protein, ligationsubstrate, and Sortase. Thus Sortase has the potential to providea means of linking expressed proteins to a wide range of solidsupports which is mild, selective, and can be carried out in a singlestep. Here we investigate the ability of S. aureus SrtA to ligate proteinsto a range of solid supports.

RESULTSPlasmid vectors were constructed for the expression of Bluefluorescent protein (BFP, Q-Biogene), Enhanced Green Fluores-cent Protein (EGFP), a red fluorescent protein (DsRed), and thesequence specific DNA binding protein Tus [24] with a C-terminal LPETGG sequence followed by a hexahistidine tag. Theproteins were expressed in BL21(DE3) and purified beforeattachment to solid supports.Our first target was the immobilization of proteins onto cross-

linked polymer beads. Glycidyl methacrylate (GMA) beads weremodified with a spacer followed by one, two, or four glycineresidues. Mono-glycine, di-glycine, and tetra-glycine beads wereincubated with EGFP-LPETGG-His6 (85 mM) and His6-Sortase A(40 nM) in Sortase buffer (50 mM Tris-HCl, 150 mM NaCl,5 mM CaCl2, pH 7.5). As a control, beads with no glycinecoupled were incubated with Sortase and EGFP-LPETGG-His6,and tetraglycine beads were incubated with EGFP-LPETGG-His6in the absence of Sortase. Samples were taken at various timepoints and beads analysed by FACS (Figure 1) and fluorescencemicroscopy (Figure 2). The labeled beads were clearly visible byfluorescence microscopy while beads from control reactionsshowed no increase in fluorescence. Tetra-glycine beads showedthe most rapid fluorescence increase and the highest finalfluorescence. Di-glycine beads were nearly as effective as tetra-glycine with mono-glycine beads showing slower increase andsignificantly reduced final fluorescence.EGFP and the other fluorescent proteins are extremely robust.

While the fluorescence analysis of the ligation of these proteinsdemonstrates maintenance of function it is therefore of interest todemonstrate that more fragile proteins can be ligated to solidsupports while maintaining function. This is crucial for applica-tions in supported catalysis or bead-based protein arrays. Todemonstrate that ligated protein was functional and accessible toother molecules in solution Tus-LPETGG-His6 was immobilizedon tetraglycine GMA beads. Tus is a sequence specific DNA-binding protein that recognizes 21 bp Ter sites [24]. The Tus-labeled GMA beads were incubated with different proportions offluorescein labeled TerB DNA and a 21 bp Cy5-labeled DNA

sequence unrelated to TerB in binding buffer (50 mM Tris-HCl,250 mM KCl, 0.1 mM EDTA, 0.1 mM DTT, pH 9). The totalDNA concentration (Ter plus nonspecific DNA) was 100 nM forall samples. The fluorescein and Cy5 fluorescence of the beads wasdetermined by FACS analysis. Non-specific DNA binding wasvery low in all cases, consistent with the low affinity of Tus for non-specific DNA in 250 mM KCl [25]. Ter binding showeda concentration dependence that was consistent with anequilibrium dissociation constant of 2968 nM (Figure 3), whichcompares well with values of KD measured by fluorescenceanisotropy (,15 nM at 37uC) or Biacore (,1 nM at 25uC) [25].To demonstrate attachment to other solid supports a beaded

agarose affinity support (Affi-Gel 102 resin, Bio-Rad) was modifiedwith oligoglycine by incubating the amino-resin with diglycine(0.5 M) and EDC (2.5 mM) for three hours at 50uC. BFP-, EGFP-,and DsRed-LPETGG-His6 were then ligated to the resinovernight at room temperature. After washing the resin columnscould be seen to be clearly labeled with fluorescent protein(Figure 4a,b) whereas a control (EGFP without Sortase) showed nofluorescence. The labeled Affi-Gel beads were clearly visible byfluorescence microscopy (Figure 2).

Figure 1. Ligation of fluorescent proteins to polymer beads. (a) GMAbeads modified with one, two, or four glycine residues were incubatedwith EGFP-LPETGG-His6 and Sortase. Samples were taken at specifictime points and analyzed on a BD FACSAria. Controls contained beadswith no glycine or diglycine beads without Sortase. Error bars showingthe standard error in the mean fluorescence are omitted as they aregenerally smaller than the data symbols. Errors are given inSupplementary Data S2.doi:10.1371/journal.pone.0001164.g001

Figure 2. Fluorescence micrographs of labeled solid supports. (a)Diglycine GMA beads and (b) oligoglycine modified Affigel resin wereseparately labeled with EGFP and DsRed and then mixed. Fluorescenceimages were recorded as separate gray scale images (see Supplemen-tary Figure S2) with FITC and Cy3 filter sets and then combined andfalse coloured.doi:10.1371/journal.pone.0001164.g002

Sortase-Mediated Ligation

PLoS ONE | www.plosone.org 2 November 2007 | Issue 11 | e1164

...when we publish...Wednesday, 14 December 11

...publish the data...


...in the right places...


...the software...Wednesday, 14 December 11

...and all the rest?Wednesday, 14 December 11


Flickr tag: UC207

http://usefulchem.wikispaces.com/Exp207









http://www.flickr.com/photos/stuartpilbrow/3345896050 CC-BY-SAWednesday, 14 December 11

http://www.flickr.com/photos/stuartpilbrow/3345896050

http://www.flickr.com/photos/stuartpilbrow/3345896050

This is not sustainable...


“I need to publish more”


...not work more...


We have...

http://www.flickr.com/photos/schnurrbart/43568532 CC-BY-SA


http://www.flickr.com/photos/schnurrbart/43568532

http://www.flickr.com/photos/schnurrbart/43568532

A resource problem...

http://www.flickr.com/photos/mukumbura/4052671706 CC-BY-SAWednesday, 14 December 11

http://www.flickr.com/photos/mukumbura/4052671706

http://www.flickr.com/photos/mukumbura/4052671706

Whether it’s money...


...or time...

http://www.flickr.com/photos/robbie73/3387189144 CC-BY-SAWednesday, 14 December 11

http://www.flickr.com/photos/robbie73/3387189144


Technical capacity is not enough


...either need to resource it


...or make it cheaper.



Publication as a side effect of recording....


“Publish@Source”Jeremy Frey,Southampton




http://usefulchem.wikispaces.com/Exp258Wednesday, 14 December 11



http://www.carlboettiger.info/Wednesday, 14 December 11

http://www.carlboettiger.info

http://www.carlboettiger.info

http://www.myexperiment.org/workflows/204.htmlWednesday, 14 December 11

http://www.myexperiment.org/workflows/204.html

http://www.myexperiment.org/workflows/204.html


http://www.flickr.com/photos/psychemedia/Wednesday, 14 December 11

http://www.flickr.com/photos/psychemedia/

http://www.flickr.com/photos/psychemedia/

Easy to publish pieces...

http://www.flickr.com/photos/horiavarlan/4514164700 CC-BYWednesday, 14 December 11

http://www.flickr.com/photos/horiavarlan/4514164700

http://www.flickr.com/photos/horiavarlan/4514164700

...and then collect








So we capture and collect...

http://www.flickr.com/photos/furtwangl/3851841424




...then tell the story

Dionaea muscipula Musca domesticachomped on


http://www.flickr.com/photos/lizadaly/2944376209 CC-BY

...aggregate existing pieces


http://www.flickr.com/photos/lizadaly/2944376209

http://www.flickr.com/photos/lizadaly/2944376209

http://www.flickr.com/photos/bladeflyer/442496389 CC-BY

...we can open the floodgates...


http://www.flickr.com/photos/bladeflyer/442496389

http://www.flickr.com/photos/bladeflyer/442496389

...all the way...http://www.flickr.com/photos/fraz5356/4754482759 CC-BYWednesday, 14 December 11

http://www.flickr.com/photos/fraz5356/4754482759

http://www.flickr.com/photos/fraz5356/4754482759

It’ll be great...right?http://www.flickr.com/photos/62337512@N00/3958637561 CC-BY




group, and finally attachment to the solid support. In addition theuse of intein based methods as well as the preparation of the solidsupport for Staudinger ligation often require reagents such asphosphines or thiophenols that are toxic and difficult to handle.Therefore there remains a significant need for robust and simple

methodologies for protein immobilization that can be applied towide range of proteins and solid supports. The identification of theSortase transpeptidase [19] provided an alternative approach toprotein ligation. Sortases recognise a specific peptide sequence(LPETG for SrtA of S. aureus used in this work) in proteins targetedfor covalent attachment to the cell wall peptidoglycan. The peptidetag sequence is cleaved and then ligated to the pentaglycine moietyon the peptidoglycan precursor Lipid II. Proteins expressed with theC-terminal recognition sequence can be covalently attached to a widerange of constructs with an N-terminal glycine amidemotif includingpeptides [20], PNA [21], full length proteins [22] and small moleculesubstrates [23]. Another group has independently described anexample of Sortase mediated ligation to a beaded solid support [22].These reactions proceed under aqueous conditions without theaddition of any further reagents beyond the protein, ligationsubstrate, and Sortase. Thus Sortase has the potential to providea means of linking expressed proteins to a wide range of solidsupports which is mild, selective, and can be carried out in a singlestep. Here we investigate the ability of S. aureus SrtA to ligate proteinsto a range of solid supports.

Figure 1. Ligation of fluorescent proteins to polymer beads. (a) GMAbeads modified with one, two, or four glycine residues were incubatedwith EGFP-LPETGG-His6 and Sortase. Samples were taken at specifictime points and analyzed on a BD FACSAria. Controls contained beadswith no glycine or diglycine beads without Sortase. Error bars showingthe standard error in the mean fluorescence are omitted as they aregenerally smaller than the data symbols. Errors are given inSupplementary Data S2.doi:10.1371/journal.pone.0001164.g001

All of this information...data....












Flickr tag: UC207















http://www.flickr.com/photos/waltstoneburner/3372746317 CC-BY


http://www.flickr.com/photos/waltstoneburner/3372746317


Retractions per 100k papers30

25

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15

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Retr

actio

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00k

publ

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201020001990198019701960Year


http://www.flickr.com/photos/oakleyoriginals/2879794262 CC-BYWednesday, 14 December 11

http://www.flickr.com/photos/oakleyoriginals/2879794262

http://www.flickr.com/photos/oakleyoriginals/2879794262

watercannon?

http://www.flickr.com/photos/7827294@N04/4621721577 CC-BYWednesday, 14 December 11



Information overload...

http://www.flickr.com/photos/dylanroscover/3450505729 CC-BY-SA


http://www.flickr.com/photos/dylanroscover/3450505729

http://www.flickr.com/photos/dylanroscover/3450505729

“I need to read less”


Filter failure?

http://www.flickr.com/photos/daveyll/332723930Wednesday, 14 December 11

http://www.flickr.com/photos/daveyll/332723930

http://www.flickr.com/photos/daveyll/332723930

http://www.flickr.com/photos/biscuitsmlp/2247299538 CC-BY


http://www.flickr.com/photos/biscuitsmlp/2247299538


Filters block.

http://www.flickr.com/photos/emperley3/4705354106 CC-BY-SAWednesday, 14 December 11

http://www.flickr.com/photos/emperley3/4705354106


http://www.flickr.com/photos/robmcm/1671702203 CC-BY-SA

You think this is a good thing...


http://www.flickr.com/photos/robmcm/1671702203

http://www.flickr.com/photos/robmcm/1671702203

http://www.flickr.com/photos/mrehan00/3700858676 CC-BY-SA

...we’re “protecting our community from a deluge”


http://www.flickr.com/photos/mrehan00/3700858676

http://www.flickr.com/photos/mrehan00/3700858676

...staying on the straight and narrow...

http://www.flickr.com/photos/quinnanya/4813974125 CC-BYWednesday, 14 December 11

http://www.flickr.com/photos/quinnanya/4813974125

http://www.flickr.com/photos/quinnanya/4813974125

Or are we just limiting our ability to explore...?

http://www.flickr.com/photos/jurvetson/2174000357 CC-BYWednesday, 14 December 11



http://www.flickr.com/photos/joiseyshowaa/2374526016 CC-BY

...and discover...?


http://www.flickr.com/photos/joiseyshowaa/2374526016

http://www.flickr.com/photos/joiseyshowaa/2374526016

Filters block.




The right filter for me? Right filter for now?

http://www.flickr.com/photos/lotzman/3595748169 CC-BYWednesday, 14 December 11

http://www.flickr.com/photos/lotzman/3595748169

http://www.flickr.com/photos/lotzman/3595748169


Remember this graph?30

25

20

15

10

5

0

Retr

actio

ns p

er 1

00k

publ

icat

ions

201020001990198019701960Year



25

20

15

10

5

0

Retr

actio

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00k

publ

icat

ions

201020001990198019701960Year

Where is the data from?Wednesday, 14 December 11


25

20

15

10

5

0

Retr

actio

ns p

er 1

00k

publ

icat

ions

201020001990198019701960Year

https://github.com/neilfws/PubMed/blob/master/data/retractions.txt





25

20

15

10

5

0

Retr

actio

ns p

er 1

00k

publ

icat

ions

201020001990198019701960Year





But how did I discover it?


http://friendfeed.com/gbilder/711e6278/so-how-many-retractions-are-there-every-year











Remember these people?


Helen BermanLorie LeJeune

Iain Emsley

Neil Saunders

Brian Kelly

Harry Collins

Michael Nielsen

Jen Dodd

Greg Wilson

Timo Hannay

Maxine Clarke

Jenny RohnRicardo Vidal Paulo Nuin

Jenny HalePeter Murray-Rust

Deepak Singh

Jon Udell

Tim O’Reilly

David Crotty

Rafael Sidi

Richard Akerman

Jean-Claude Bradley

Mike Ellis

Liz Lyons

Andy Powell

Gavin Baker Peter Suber

Victor Henning

Sabine HossenfelderFlickr

Google

Steve Wilson

Andrew Milsted

Frank Norman

Dave de RoureJeremy Frey

John Cumbers

Bill Flanagan

ISIS LSS Group

Lakshmi Shastry

Catherine Jones

ISIS Computing GroupSTFC

Plausible AccuracyJohn

Dupuis

Chad Orzel

Ken Shankland

Martyn Bull

Jonathan Gray

Rufus Pollock

Clay Shirky

Kevin Kelly

Gavin Bell

Shirley Wu

Euan Adie

Richard Curry Ian Mulvany

Jamie McQuay

Atilla Csordas

Pawel Szcsesny Gabriel Cavalli

Matt Wood

TIM HUBBARD

DUNCAN HULL

Richard Grant Branwen Hide

PLoS

Friendfeed

Bora Zivkovic

Peter Binfield

John Wilbanks

Kaitlin ThaneyThe BioGang

Tony WilliamsEgon Willighagen

Martin FennerYaroslav Nikolaev

Jon EisenMichael Eisen

Richard Akerman

Jeremiah FaithMichael Barton

Lee Smolin

Garret Lisi

Victoria Stodden

Simon ColesTony Hey

Noel Gorelick

Jon Tansley

Benjamin Good Dorothea Salo

Paul Walk

Mitch Waldrop

Björn Brembs

Rich Apodaca

Bill Hooker

Pedro Beltrao

Mat Todd

SciFoo 2008/9

campers

Stephen Brenner

Brian Matthews

Allyson Lister

Phil Lord

Steve Koch

Koch Lab

Carole Goble

Stephen FriendEva Amsen

JOHN WILLINSKY

TIM HUBBARDTIM HUBBARDTIM HUBBARD

Steph Hannon

Rebecca Goulding

Leigh Dodds

Paul Miller

Mark BorkumDan Hagon

Jim Downing

Nico Adams

@gnatFabiana Kubke

Hope LemanLisa Green

Ariel Waldmann

@tGrace Baynes

Simon Philips

Matt Johnson

Lee Dirks

Microsoft

NPG Ben Goldacre

Arfon Smith

Nicholas Cole

Chris Leonard

PIERRE LINDENBAUM

ALAN CANN

Jo Badge

Mummi Thorissson

Andrew Kasarskis

Glyn Moody

@communicating

PT Sefton

Andrew Farke







Social aggregation...


...but also...



Social annotation


...and quality assessment

http://www.flickr.com/photos/pinksherbet/3209939998 CC-BYWednesday, 14 December 11

http://www.flickr.com/photos/pinksherbet/3209939998


...but also...


http://nsaunders.wordpress.com/2010/11/30/analysis-of-retractions-in-pubmed/








A network of linked objects...


...primed for discovery...



It’s not filter failure




...it’s a discovery deficit...

http://www.flickr.com/photos/nationallibrarynz_commons/4078337883 Public Domain


http://www.flickr.com/photos/nationallibrarynz_commons/4078337883

http://www.flickr.com/photos/nationallibrarynz_commons/4078337883

http://flickr.com/photos/stewart/461099066/

In the last year...?




...in the past 24 hours?Wednesday, 14 December 11

Is search the answer?

http://www.flickr.com/photos/ezioman/2096469724 CC-BY


http://www.flickr.com/photos/ezioman/2096469724

http://www.flickr.com/photos/ezioman/2096469724

http://www.flickr.com/photos/mangostrawberry/5490992826 CC-BY

...or something more...?


http://www.flickr.com/photos/mangostrawberry/5490992826

http://www.flickr.com/photos/mangostrawberry/5490992826

Need the right instrument...

http://www.flickr.com/photos/conskeptical/269403030 CC-BY-SAWednesday, 14 December 11

http://www.flickr.com/photos/conskeptical/269403030

http://www.flickr.com/photos/conskeptical/269403030

...not every problem is a nailhttp://www.flickr.com/photos/bb_matt/207102083 CC-BYWednesday, 14 December 11

http://www.flickr.com/photos/bb_matt/207102083

http://www.flickr.com/photos/bb_matt/207102083


Blog/Wiki!LIMS!

Data repository!Local file stores!

Online file stores!

RSS

/Ato

m F

eeds!

Upl

oadi

g ob

ject

s!

Map Reduce/!Hadoop!

Workflows!


http://www.flickr.com/photos/striatic/125614 CC-BY

Some way away yet...


http://www.flickr.com/photos/striatic/125614

http://www.flickr.com/photos/striatic/125614


http://www.flickr.com/photos/cappellmeister/39508741 CC-BY

technologies...




PublicationAggregationDiscovery








conceptual changes...

http://www.flickr.com/photos/ivanwalsh/4509575889 CC-BYWednesday, 14 December 11



Publish pieces...then aggregate


Don’t filter...enable discovery


...central principle.

http://www.flickr.com/photos/mkumm/2709555496 CC-BY




Networks scale


0

0.25

0.50

0.75

1.00

1982 1986 1990 1994 1998 2002 2006

Average Capacity of Human Researcher


0

0.75

1.50

2.25

3.00

1982 1986 1990 1994 1998 2002 2006

Average Capacity of Norwegian Researcher


People don’t scale...


Neither do computers...

http://www.flickr.com/photos/argonne/3323018571 CC-BY-SA


http://www.flickr.com/photos/argonne/3323018571


...at least not on their own


Open networks scale


...closed networks do not.http://www.flickr.com/photos/andypowe11/3759152528Wednesday, 14 December 11



We need...


http://flickr.com/photos/virtualsugar/316200555/ CC-BYWednesday, 14 December 11

http://flickr.com/photos/virtualsugar/316200555/

http://flickr.com/photos/virtualsugar/316200555/


Open data...

http://www.flickr.com/photos/jwyg/4528443760/ CC-BY-SAWednesday, 14 December 11

http://www.flickr.com/photos/jwyg/4528443760/

http://www.flickr.com/photos/jwyg/4528443760/

...but also...


...open platforms for innovation

http://www.flickr.com/photos/37984062@N03/3495256118 CC-BY-SAWednesday, 14 December 11



http://www.flickr.com/photos/tomarthur/3593729997

Optimise for....




....not this

http://www.flickr.com/photos/vrogy/514733529





http://www.flickr.com/photos/biscuitsmlp/2247299538 CC-BY-SA




http://www.flickr.com/photos/tammra/283690669/




Because every time a permanent job is advertised...


http://www.flickr.com/photos/t3rmin4t0r/3947963283 CC-BY


http://www.flickr.com/photos/t3rmin4t0r/3947963283


http://www.flickr.com/photos/t3rmin4t0r/3947963283 CC-BY

The one with the most Nature papers

gets to mate...




We optimise for...

http://www.flickr.com/photos/klausnahr/4437823757 CC-BY-SA


http://www.flickr.com/photos/klausnahr/4437823757

http://www.flickr.com/photos/klausnahr/4437823757

http://www.flickr.com/photos/frozenchipmunk/197591546 CC-BY

Rather than for use and re-use...


http://www.flickr.com/photos/frozenchipmunk/197591546

http://www.flickr.com/photos/frozenchipmunk/197591546

...because of the incentives...http://www.flickr.com/photos/daquellamanera/3238300837 CC-BYWednesday, 14 December 11

http://www.flickr.com/photos/daquellamanera/3238300837

http://www.flickr.com/photos/daquellamanera/3238300837

http://www.flickr.com/photos/lifeontheedge/247473398 CC-BY-SAWednesday, 14 December 11

http://www.flickr.com/photos/lifeontheedge/247473398

http://www.flickr.com/photos/lifeontheedge/247473398

http://www.flickr.com/photos/turtlemom_nancy CC-BY-SA


http://www.flickr.com/photos/turtlemom_nancy/

http://www.flickr.com/photos/turtlemom_nancy/

We are stuck with “impact”...

http://www.flickr.com/photos/babasteve/3140688308 CC-BYWednesday, 14 December 11



...but we can mould it.

http://www.flickr.com/photos/waltstoneburner/5745387762 CC-BYWednesday, 14 December 11



An assertion.


We want to see research used.


In the right places...

http://www.flickr.com/photos/ol1/6048544977 CC-BY-SA


http://www.flickr.com/photos/ol1/6048544977

http://www.flickr.com/photos/ol1/6048544977


http://www.flickr.com/photos/velkr0/3472576304 CC-BY



http://www.flickr.com/photos/velkr0/3472576304

http://www.flickr.com/photos/velkr0/3472576304

http://www.flickr.com/photos/argonne/3465398655 CC-BY





...at the right time.

http://www.flickr.com/photos/robbie73/3387189144 CC-BY-SAWednesday, 14 December 11



We want research to be re-used and re-usable



Impact = Re-use


Application = Re-use


Commercialised = Re-use


Education = Re-use


Engagement = Re-use


...but also...


Citation = Re-use


http://www.flickr.com/photos/sterlic/4299631538 CC-BY-SA

Can we measure re-use?


http://www.flickr.com/photos/sterlic/4299631538

http://www.flickr.com/photos/sterlic/4299631538

Bollen et al., PLoS ONE 4(6): e6022 doi:10.1371/journal.pone.0006022.g002


The web changes everything...

http://www.flickr.com/photos/jurvetson/916142 CC-BYWednesday, 14 December 11



New tracks to followhttp://www.flickr.com/photos/mikebaird/2985066755 CC-BY


http://www.flickr.com/photos/mikebaird/2985066755

http://www.flickr.com/photos/mikebaird/2985066755

ScienceCard by Martin Fenner - http://sciencecard.org/CameronNeylon




Altmetric.com by Euan Adie - http://altmetric.com/interface/explorer.html


http://altmetric.com/interface/explorer.html

http://altmetric.com/interface/explorer.html

Bookmarks = Re-use


Discussion = Re-use


...and we can track them all

http://www.flickr.com/photos/paul_white/5831407787 CC-BY


http://www.flickr.com/photos/paul_white/5831407787

http://www.flickr.com/photos/paul_white/5831407787

...on an open network.


But what about...?




Maximise potential...

http://www.flickr.com/photos/pinksherbet/3370498053 CC-BY




...for discovery and re-use...

http://www.flickr.com/photos/pagedooley/3797236989 CC-BYWednesday, 14 December 11

http://www.flickr.com/photos/pagedooley/3797236989


Measure re-use and re-usability...




Optimise for impact

http://www.flickr.com/photos/gsfc/6147894106 CC-BY


http://www.flickr.com/photos/gsfc/6147894106

http://www.flickr.com/photos/gsfc/6147894106

...and the easiest way...


http://www.flickr.com/photos/virtualsugar/316200555 CC-BYWednesday, 14 December 11

http://www.flickr.com/photos/virtualsugar/316200555

http://www.flickr.com/photos/virtualsugar/316200555

Not the only way.


...but the easiest and most common

http://www.flickr.com/photos/ehamiter/4607728796 CC-BY-SA


http://www.flickr.com/photos/ehamiter/4607728796

http://www.flickr.com/photos/ehamiter/4607728796

The solutions won’t come from where we expect...


Open networks scale


...enable solutions to discover problems...


...at all levelshttp://www.flickr.com/photos/37850028@N05/5111113034 CC-BY




..from the research





...to the technology...


...to the architecture

http://www.flickr.com/photos/yakobusan/2436481628 CC-BYWednesday, 14 December 11

http://www.flickr.com/photos/yakobusan/2436481628

http://www.flickr.com/photos/yakobusan/2436481628

Build open networks...





Enable discovery...

http://www.flickr.com/photos/pagedooley/2836337974 CC-BY




The rest will follow...



Technology

I want to publish more and read less